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https://www.readbyqxmd.com/read/29149237/multimorbidity-among-persons-living-with-hiv-in-the-u-s
#1
Cherise Wong, Stephen J Gange, Richard D Moore, Amy C Justice, Kate Buchacz, Alison G Abraham, Peter F Rebeiro, John R Koethe, Jeffrey N Martin, Michael A Horberg, Cynthia M Boyd, Mari M Kitahata, Heidi M Crane, Kelly A Gebo, M John Gill, Michael J Silverberg, Frank J Palella, Pragna Patel, Hasina Samji, Jennifer Thorne, Charles S Rabkin, Angel Mayor, Keri N Althoff
Background: Age-associated conditions are increasingly common among persons living with HIV. A longitudinal investigation of their accrual is needed given their implications on clinical care complexity. We examined trends in the co-occurrence of age-associated conditions among persons living with HIV receiving clinical care, and differences in their prevalence by demographic subgroup. Methods: This cohort study was nested within the North American AIDS Cohort Collaboration on Research and Design...
November 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29149130/errors-in-genetic-testing-common-causes-and-strategies-for-prevention
#2
Suzanne M Mahon
Genetic testing for hereditary cancer syndromes is an integral component of oncology care. Various types of common errors that occur in the genetic testing process are presented in this article with actual clinical case examples and commentary. Genetic errors are expensive and may result in poor outcomes for the patient and his or her family. Oncology nurses need to be aware of potential sources of error and advocate for comprehensive genetic care.
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December 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29148430/low-dose-4d-cardiac-imaging-in-small-animals-using-dual-source-micro-ct
#3
Matthew Holbrook, Darin P Clark, Cristian T Badea
Micro-CT is widely used in preclinical studies, generating substantial interest in extending its capabilities in functional imaging applications such as blood perfusion and cardiac function. However, imaging cardiac structure and function in mice is challenging due to their small size and rapid heart rate. To overcome these challenges, we propose and compare improvements on two strategies for cardiac gating in dual-source, preclinical micro-CT: fast prospective gating (PG) and uncorrelated retrospective gating (RG)...
November 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29148135/cadence-tracking-and-disturbance-rejection-in-functional-electrical-stimulation-cycling-for-paraplegic-subjects-a-case-study
#4
Lucas O da Fonseca, Antônio P L Bó, Juliana A Guimarães, Miguel E Gutierrez, Emerson Fachin-Martins
Functional electrical stimulation cycling has been proposed as an assistive technology with numerous health and fitness benefits for people with spinal cord injury, such as improvement in cardiovascular function, increase in muscular mass, and reduction of bone mass loss. However, some limitations, for example, lack of optimal control strategies that would delay fatigue, may still prevent this technology from achieving its full potential. In this work, we performed experiments on a person with complete spinal cord injury using a stationary tadpole trike when both cadence tracking and disturbance rejection were evaluated...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/29148076/subjective-cognitive-complaints-psychosocial-factors-and-nursing-work-function-in-nurses-providing-direct-patient-care
#5
Tammy Barbe, Laura P Kimble, Cynthia Rubenstein
AIMS: The aim of this study was to examine relationships among subjective cognitive complaints, psychosocial factors and nursing work function in nurses providing direct patient care. BACKGROUND: Cognitive functioning is a critical component for nurses in the assurance of error prevention, identification and correction when caring for patients. Negative changes in nurses' cognitive and psychosocial functioning can adversely affect nursing care and patient outcomes...
November 17, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29146681/a-qualitative-study-of-patient-involvement-in-medicines-management-after-hospital-discharge-an-under-recognised-source-of-systems-resilience
#6
Beth Fylan, Gerry Armitage, Deirdre Naylor, Alison Blenkinsopp
INTRODUCTION: There are risks to the safety of medicines management when patient care is transferred between healthcare organisations, for example, when a patient is discharged from hospital. Using the theoretical concept of resilience in healthcare, this study aimed to better understand the proactive role that patients can play in creating safer, resilient medicines management at a common transition of care. METHODS: Qualitative interviews with 60 cardiology patients 6 weeks after their discharge from 2 UK hospitals explored patients' experiences with their discharge medicines...
November 16, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29145243/obstructive-internal-hernia-caused-by-mesodiverticular-bands-in-children-two-case-reports-and-a-review-of-the-literature
#7
Mirko Bertozzi, Berardino Melissa, Elisa Magrini, Giuseppe Di Cara, Susanna Esposito, Antonino Apignani
INTRODUCTION: The mesodiverticular band (MDB) is an embryologic remnant of the vitelline circulation, which carries the arterial supply to the Meckel diverticulum. In the event of an error of involution, a patent or nonpatent arterial band persists and extends from the mesentery to the apex of the antimesenteric diverticulum. This creates a snare-like opening through which bowel loops may herniate and become obstructed. This report describes 2 rare cases of small bowel occlusion owing to an internal hernia caused by a MDB...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143867/correction-to-metoclopramide-role-in-preventing-ileus-after-cesarean-a-clinical-trial
#8
Jila Agah, Roya Baghani, Mohammad Hassan Rakhshani, Abolfazl Rad
The original publication of this paper contains an error.
November 16, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29143201/newborn-screening-for-lysosomal-storage-disorders-by-tandem-mass-spectrometry-in-north-east-italy
#9
Alberto B Burlina, Giulia Polo, Leonardo Salviati, Giovanni Duro, Carmela Zizzo, Andrea Dardis, Bruno Bembi, Chiara Cazzorla, Laura Rubert, Roberta Zordan, Robert J Desnick, Alessandro P Burlina
BACKGROUND: Lysosomal storage diseases (LSDs) are inborn errors of metabolism resulting from 50 different inherited disorders. The increasing availability of treatments and the importance of early intervention have stimulated newborn screening (NBS) to diagnose LSDs and permit early intervention to prevent irreversible impairment or severe disability. We present our experience screening newborns in North East Italy to identify neonates with Mucopolysaccharidosis type I (MPS I) and Pompe, Fabry, and Gaucher diseases...
November 15, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29143074/-additional-emergency-medical-measures-in-trauma-associated-cardiac-arrest
#10
B Ondruschka, C Baier, J Dreßler, A Höch, M Bernhard, C Kleber, C Buschmann
INTRODUCTION: More than half of all traumatic deaths happen in prehospital settings. Until now, there have been no long-term studies examining the actual additive treatment during trauma-associated cardiopulmonary resuscitation (tCPR), including pleural decompression, pericardiocentesis, tourniquets and external stabilization of the pelvis. The present cohort study evaluated forensic autopsy reports of trauma deaths occurring at the scene with respect to additive actions in preclinical tCPR as well as the potentially preventable nature of the individual death cases...
November 15, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/29142413/antiurolithiatic-potential-of-neeri-against-calcium-oxalate-stones-by-crystallization-inhibition-free-radicals-scavenging-and-nrk-52e-cell-protection-from-oxalate-injury
#11
Parveen Kumar Goyal, Santosh Kumar Verma, Anil Kumar Sharma
Background: Neeri is a well-established polyherbal formulation prescribed for renal stones by the physicians but has not been experimentally evaluated for its antiurolithiatic potential using cell-lines. Objective: This study is aimed to scientifically substantiate the antiurolithiatic effect of Neeri extract (NRE) through calcium oxalate (CaOx) crystallization inhibition, scavenging of free radicals, and protection of renal tubular epithelial NRK-52E cells from oxalate-induced injury...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29141983/are-parents-who-feel-the-need-to-watch-over-their-children-s-care-better-patient-safety-partners
#12
Elizabeth D Cox, Kristofer Hansen, Victoria P Rajamanickam, Roger L Brown, Paul J Rathouz, Pascale Carayon, Lori L DuBenske, Linda A Buel, Michelle M Kelly
OBJECTIVES: Many parents report needing to watch over their child's hospital care to prevent mistakes. In this study, we assessed whether needing to watch over care predicts parent performance of recommended safety behaviors to reduce medication errors and health care-associated infections. METHODS: At admission, we surveyed 170 parents about their need to watch over care, demographics, and hospitalization factors. At discharge, parents were surveyed about medication awareness and hand hygiene behaviors...
November 15, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/29141979/measurement-errors-in-dietary-assessment-using-self-reported-24-hour-recalls-in-low-income-countries-and-strategies-for-their-prevention
#13
Rosalind S Gibson, U Ruth Charrondiere, Winnie Bell
Securing accurate measurements of dietary intake across populations is challenging. Of the methods, self-reported 24-h recalls are often used in low-income countries (LICs) because they are quick, culturally sensitive, do not require high cognitive ability, and provide quantitative data on both foods and nutrients. Measuring intakes via 24-h recalls involves 1) collecting data on food intakes, 2) the appropriate use of relevant food-composition data for calculating nutrient intakes, and 3) statistically converting observed intakes to "usual intakes" for evaluating nutrient adequacy or relations between foods and nutrients and health outcomes...
November 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/29140145/monitoring-rugby-players-for-fitness-and-fatigue-what-do-coaches-want
#14
Lindsay T Starling, Michael I Lambert
PURPOSE: The advantages of monitoring players in a team are well documented. However, barriers associated with lack of resources and time prevents teams from implementing systematic monitoring programs. This study aims to identify 1) the methods rugby teams use to monitor the training load and associated response to the training load, and 2) prerequisites of a monitoring protocol that are scientifically suitable and practically applicable for monitoring fitness and fatigue of rugby players...
November 15, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29138993/adverse-drug-events-and-medication-errors-in-african-hospitals-a-systematic-review
#15
REVIEW
Alemayehu B Mekonnen, Tariq M Alhawassi, Andrew J McLachlan, Jo-Anne E Brien
BACKGROUND: Medication errors and adverse drug events are universal problems contributing to patient harm but the magnitude of these problems in Africa remains unclear. OBJECTIVE: The objective of this study was to systematically investigate the literature on the extent of medication errors and adverse drug events, and the factors contributing to medication errors in African hospitals. METHODS: We searched PubMed, MEDLINE, EMBASE, Web of Science and Global Health databases from inception to 31 August, 2017 and hand searched the reference lists of included studies...
November 14, 2017: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29138304/refactoring-the-genetic-code-for-increased-evolvability
#16
Gur Pines, James D Winkler, Assaf Pines, Ryan T Gill
The standard genetic code is robust to mutations during transcription and translation. Point mutations are likely to be synonymous or to preserve the chemical properties of the original amino acid. Saturation mutagenesis experiments suggest that in some cases the best-performing mutant requires replacement of more than a single nucleotide within a codon. These replacements are essentially inaccessible to common error-based laboratory engineering techniques that alter a single nucleotide per mutation event, due to the extreme rarity of adjacent mutations...
November 14, 2017: MBio
https://www.readbyqxmd.com/read/29137605/effects-of-aspirin-and-non-aspirin-nonsteroidal-anti-inflammatory-drugs-on-the-incidence-of-recurrent-colorectal-adenomas-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis-of-randomized-clinical-trials
#17
Sajesh K Veettil, Kean Ghee Lim, Siew Mooi Ching, Surasak Saokaew, Pochamana Phisalprapa, Nathorn Chaiyakunapruk
BACKGROUND: Beneficial effects of aspirin and non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) against recurrent colorectal adenomas have been documented in systematic reviews; however, the results have not been conclusive. Uncertainty remains about the appropriate dose of aspirin for adenoma prevention. The persistence of the protective effect of NSAIDs against recurrent adenomas after treatment cessation is yet to be established. METHODS: Our objective was to update and systematically evaluate the evidence for aspirin and other NSAIDs on the incidence of recurrent colorectal adenomas taking into consideration the risks of random error and to appraise the quality of evidence using GRADE (The Grading of Recommendations, Assessment, Development and Evaluation) approach...
November 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29136843/improved-assessment-of-accuracy-and-performance-using-a-rotational-paper-based-device-for-multiplexed-detection-of-heavy-metals
#18
Xiange Sun, Bowei Li, Anjin Qi, Chongguo Tian, Jinglong Han, Yajun Shi, Bingcheng Lin, Lingxin Chen
In this work, a novel rotational microfluidic paper-based device was developed to improve the accuracy and performance of the multiplexed colorimetric detection by effectively avoiding the diffusion of colorimetric reagent on the detection zone. The integrated paper-based rotational valves were used to control the connection or disconnection between detection zones and fluid channels. Based on the manipulation of the rotational valves, this rotational paper-based device could prevent the random diffusion of colorimetric reagent and reduce the error of quantitative analysis considerably...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136390/assurance-of-myeloid-growth-factor-administration-in-an-infusion-center-pilot-quality-improvement-initiative
#19
Pamela Maree Ramirez, Barry Peterson, Christine Holtshopple, Kristina Borja, Vincent Torres, Lucille Valdivia-Peppers, Julio Harriague, Melanie D Joe
PURPOSE: Four incident reports involving missed doses of myeloid growth factors (MGFs) triggered the need for an outcome-driven initiative. From March 1, 2015, to February 29, 2016, at University of California Irvine Health Chao Infusion Center, 116 of 3,300 MGF doses were missed (3.52%), including pegfilgrastim, filgrastim, and sargramostim. We hypothesized that with the application of Lean Six Sigma methodology, we would achieve our primary objective of reducing the number of missed MGF doses to < 0...
November 14, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29136193/early-first-trimester-uteroplacental-flow-and-the-progressive-disintegration-of-spiral-artery-plugs-new-insights-from-contrast-enhanced-ultrasound-and-tissue-histopathology
#20
V H J Roberts, T K Morgan, P Bednarek, M Morita, G J Burton, J O Lo, A E Frias
STUDY QUESTION: Does the use of a vascular contrast agent facilitate earlier detection of maternal flow to the placental intervillous space (IVS) in the first trimester of pregnancy? SUMMARY ANSWER: Microvascular filling of the IVS was demonstrated by contrast-enhanced ultrasound from 6 weeks of gestation onwards, earlier than previously believed. WHAT IS KNOWN ALREADY: During placental establishment and remodeling of maternal spiral arteries, endovascular trophoblast cells invade and accumulate in the lumen of these vessels to form 'trophoblast plugs'...
November 10, 2017: Human Reproduction
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