Soji Tani, Koji Ishikawa, Yoshifumi Kudo, Koki Tsuchiya, Akira Matsuoka, Hiroshi Maruyama, Haruka Emori, Ryo Yamamura, Chikara Hayakawa, Masaya Sekimizu, Yusuke Oshita, Tomoyuki Ozawa, Toshiyuki Shirahata, Takashi Nagai, Tomoaki Toyone, Katsunori Inagaki
BACKGROUND: Pedicle screw loosening is a major complication following spinal fixation associated with osteoporosis in elderly. However, denosumab is a promising treatment in patients with osteoporosis. The effect of denosumab on pedicle screw fixation is unknown. Therefore, we investigated whether denosumab treatment improves pedicle screw fixation in elderly patients with osteoporosis. METHODS: This was a 2-year prospective open-label study. From February 2015 to January 2016, we included 21 patients with postmenopausal osteoporosis who received initial denosumab treatment...
March 26, 2021: Journal of Orthopaedic Surgery and Research