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Mansour cardiac

Nicolas Noiseux, Samer Mansour, Richard Weisel, Louis-Mathieu Stevens, Shant Der Sarkissian, Katherine Tsang, Andrew M Crean, Eric Larose, Shu-Hong Li, Bernd Wintersperger, Minh Quan Vu, Ignacio Prieto, Ren-Ke Li, Denis Claude Roy, Terrence M Yau
OBJECTIVES: The IMPACT-CABG trial is the first North American multicenter phase II randomized study of intramyocardial delivery of autologous CD133(+) stem cells in patients with chronic ischemic cardiomyopathy undergoing coronary artery bypass grafting. The primary objective was to demonstrate safety, including freedom from major adverse cardiac events. The secondary objective was to evaluate feasibility of same-day autologous cell preparation. Although the trial was not powered to evaluate LV function, exploratory data were collected...
August 13, 2016: Journal of Thoracic and Cardiovascular Surgery
Farzaneh Montazerifar, Ahmad Bolouri, Raheleh Sharifian Paghalea, Mahbubeh Khodadadpour Mahani, Mansour Karajibani
Background: Clinical studies have demonstrated that adipocytokines play an important role in developing atherosclerotic cardiovascular diseases. Objective: The aim of study was to evaluate the relationship between serum resistin and leptin levels with obesity and coronary artery disease (CAD). Methods: In a cross-sectional study, we assessed the levels of serum resistin and leptin, C-reactive protein (CRP), lipid profile and cardiac enzyme tests (AST, CPK, LDH, CK-MB) in 40 CAD patients compared to 40 healthy controls...
September 12, 2016: Arquivos Brasileiros de Cardiologia
Abdelaaty A Shahat, Mansour S Alsaid, Syed Rafatullah, Mohammed O Al-Sohaibani, Mohammad K Parvez, Mohammed S Al-Dosari, Vassiliki Exarchou, Luc Pieters
BACKGROUND: Consumption of plant-derived nutraceuticals and crude drugs in traditional medicine is widely believed to confer beneficial effects in thwarting the progression of cardiovascular diseases. Rhus tripartita (family Anacardiaceae) has been traditionally used to treat a wide range of ailments. METHODS: In the present study we investigated the protective effects of an alcoholic extract of the stem part of Rhus tripartita male genotype (RTSM) on experimentally induced myocardial injury in rats...
2016: BMC Complementary and Alternative Medicine
Giovanni Di Salvo, Ghassan Siblini, Ziad Issa, Habdan Mohammed, Anas Abu Hazeem, Valeria Pergola, Nisreen Muhanna, Naif Al Qweai, Domenico Galzerano, Bahaa Fadel, Majid Fayyadh, Mansour Joufan, Zohair Halees, Ziad Bulbul
OBJECTIVE: Our aim was to evaluate left ventricular (LV) mechanics by using speckle tracking echocardiography (STE) in asymptomatic patients with abnormal origin of the left main coronary artery from the pulmonary trunk (ALCAPA), late after successful repair, in the presence of LV ejection fraction (EF) >50%. METHODS: We studied 30 ALCAPA patients (median age 4 years, range 1-25 years, NYHA class I, LVEF >50%) and 16 healthy age- and sex-matched controls (median age 5 years, range 1-25 years)...
August 26, 2016: Cardiology
Leon M Ptaszek, Benjamin White, Steven A Lubitz, Anthony P Carnicelli, E Kevin Heist, Patrick T Ellinor, Monique Machado, Jason H Wasfy, Jeremy N Ruskin, Katrina Armstrong, David F Brown, Paul D Biddinger, Moussa Mansour
Management of atrial fibrillation (AF) in the emergency department (ED) is variable because of the absence of universally adopted treatment guidelines. To address potentially preventable hospital admissions and prolonged length of stay, an AF treatment pathway was co-developed by physicians from the cardiac electrophysiology service and the department of emergency medicine at our institution. The impact of this AF pathway on patient outcomes was evaluated with a prospective, observational study conducted in a single tertiary care center from July 1, 2013, to June 30, 2014...
July 1, 2016: American Journal of Cardiology
Rachoin Rachoin, Bernard Abi Saleh, Bilal Mansour, Rayan Jo Rachwan, Wael AlJaroudi
Arrhythmogenic right ventricular cardiomyopathy is a leading cause of sudden cardiac death among athletes in Italy and the Mediterranean region. Although it often involves the right ventricle causing scarring, dilation, systolic impairment with aneurysm formation, it can also involve the left ventricle or present as isolated left ventricular cardiomyopathy. Cardiac magnetic resonance imaging is considered the gold standard in confirming the diagnosis. We summarize four cases of arrhythmogenic ventricular cardiomyopathy with different presentations observed over the past 2 years...
March 18, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Julia Critchley, Simon Capewell, Martin O'Flaherty, Niveen Abu-Rmeileh, Samer Rastam, Olfa Saidi, Kaan Sözmen, Azza Shoaibi, Abdullatif Husseini, Fouad Fouad, Nadia Ben Mansour, Wafa Aissi, Habiba Ben Romdhane, Belgin Unal, Piotr Bandosz, Kathleen Bennett, Mukesh Dherani, Radwan Al Ali, Wasim Maziak, Hale Arık, Gül Gerçeklioğlu, Deniz Utku Altun, Hatice Şimşek, Sinem Doganay, Yücel Demiral, Özgür Aslan, Nigel Unwin, Peter Phillimore, Nourredine Achour, Waffa Aissi, Riadh Allani, Chokra Arfa, Heidar Abu-Kteish, Niveen Abu-Rmeileh, Radwan Al Ali, Deniz Altun, Balsam Ahmad, Hale Arık, Özgür Aslan, Latifa Beltaifa, Nadia Ben Mansour, Kathleen Bennett, Habiba Ben Romdhane, Nabil Ben Salah, Marissa Collins, Julia Critchley, Simon Capewell, Mukesh Dherani, Yücel Demiral, Sinem Doganay, Madonna Elias, Gül Ergör, Ibtihal Fadhil, Fouad Fouad, Gül Gerçeklioğlu, Rula Ghandour, Sibel Göğen, Abdullatif Husseini, Samer Jaber, Sibel Kalaca, Rana Khatib, Rasha Khatib, Saer Koudsie, Bülent Kilic, Olfa Lassoued, Helen Mason, Wasim Maziak, Maher Abou Mayaleh, Nahed Mikki, Ghmaez Moukeh, Martin O Flaherty, Peter Phillimore, Samer Rastam, Gojka Roglic, Olfa Saidi, Gül Saatli, Ilhan Satman, Azza Shoaibi, Hatice Şimşek, Nesrien Soulaiman, Kaan Sözmen, Faten Tlili, Belgin Unal, Nigel Unwin, Nazan Yardim, Shahaduz Zaman
BACKGROUND: Middle income countries are facing an epidemic of non-communicable diseases, especially coronary heart disease (CHD). We used a validated CHD mortality model (IMPACT) to explain recent trends in Tunisia, Syria, the occupied Palestinian territory (oPt) and Turkey. METHODS: Data on populations, mortality, patient numbers, treatments and risk factor trends from national and local surveys in each country were collated over two time points (1995-97; 2006-09); integrated and analysed using the IMPACT model...
April 1, 2016: International Journal of Cardiology
Mohammed Al-Yahya, Mohammad Raish, Mansour S AlSaid, Ajaz Ahmad, Ramzi A Mothana, Mohammed Al-Sohaibani, Mohammed S Al-Dosari, Mohammad K Parvez, Syed Rafatullah
BACKGROUND/PURPOSE: Ajwa, a special variety of Saudi Arabian dates (Phoenix dactylifera L.) is a rich source of nutrients, fibers and bioactive molecules. While previous studies have shown the therapeutic value of dates phytoconstituents in liver and kidney diseases etc., its cardioprotective potential remains elusive. We therefore, investigated the cardioprotective effect of lyophilized Ajwa extract (AJLE) ex vivo as well as in vivo. METHODS: Ex vivo cardioprotective effect of AJLE was evaluated on DCFH-toxicated cardiomyoblast cells (H9C2)...
October 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Federico Canavese, Antoine Samba, Alain Dimeglio, Mounira Mansour, Marie Rousset
Various early-onset spinal deformities, particularly infantile and juvenile scoliosis (JS), still pose challenges to pediatric orthopedic surgeons. The ideal treatment of these deformities has yet to emerge, as both clinicians and surgeons still face multiple challenges including preservation of thoracic motion, spine and cage, and protection of cardiac and lung growth and function. Elongation-derotation-flexion (EDF) casting is a technique that uses a custom-made thoracolumbar cast based on a three-dimensional correction concept...
December 18, 2015: World Journal of Orthopedics
Quinn R Pack, Ray W Squires, Claudia Valdez-Lowe, Mouhamad Mansour, Randal J Thomas, Steven J Keteyian
PURPOSE: For patients hospitalized for a cardiac event, an earlier appointment to outpatient cardiac rehabilitation (CR) increases participation. However, it is unknown what effect hastening CR enrollment might have among employed patients planning to return to work (RTW). METHODS: Using 2 complementary data sets from Henry Ford Hospital (HFH) and Mayo Clinic, we assessed when employed patients eligible for CR anticipated a RTW, the impact of an earlier appointment on CR enrollment, and the effect of employment status on the number of CR sessions attended...
November 2015: Journal of Cardiopulmonary Rehabilitation and Prevention
El-Sayed M El-Sayed, Ahmed M Mansour, Mohammed S Abdul-Hameed
The aim of this study was to assess the possible protective effects of thymol and carvacrol (CAR) against doxorubicin (DOX)-induced cardiotoxicity. A single dose of DOX (10 mg/kg i.v.) injected to male rats revealed significant increases in serum lactate dehydrogenase, creatine kinase, creatine kinase isoenzyme-MB, aspartate transaminase, tumor necrosis factor-alpha, and cardiac troponin levels. It also increased heart contents of malondialdehyde and caspase-3 accompanied by a significant reduction in heart content of reduced glutathione as well as catalase and superoxide dismutase activity as compared with the control group...
January 2016: Journal of Biochemical and Molecular Toxicology
Federico Canavese, Marie Rousset, Mounira Mansour, Antoine Samba, Alain Dimeglio
Infantile and juvenile scoliosis, among different types of spinal deformity, is still a challenge for pediatric orthopedic surgeons. The ideal treatment of infantile and juvenile scoliosis has not yet been identified as both clinicians and surgeons still face multiple challenges, including preservation of the thoracic spine, thoracic cage, lung growth and cardiac function without reducing spinal motion. Elongation, derotation, flexion (EDF) casting technique is a custom-made thoracolumbar cast based on a three dimensional correction concept...
February 2016: Minerva Pediatrica
Heba H Mansour, Shereen M El Kiki, Hesham F Hasan
Cyclophosphamide (CP) is an oxazaphosphorine nitrogen mustard alkylating drug used for the treatment of chronic and acute leukemias, lymphoma, myeloma, and cancers of the breast and ovary. It is known to cause severe cardiac toxicity. This study investigated the protective effect of N-Acetylcysteine (NAC) on CP-induced cardiotoxicity in rats. CP resulted in a significant increase in serum aminotransferases, creatine kinase (CK), lactate dehydrogenase(LDH) enzymes, asymmetric dimethylarginine and tumor necrosis factor-α and significant decrease in total nitrate/nitrite(NOx)...
September 2015: Environmental Toxicology and Pharmacology
Ahmed M Habib, Al-Rehan Dhanji, Sherif A Mansour, Alan Wood, Wael I Awad
OBJECTIVES: EuroSCORE is used to predict operative mortality following cardiac surgery. There are limited data to assess the ability of EuroSCORE to predict medium- to long-term survival. We aimed to test the ability of EuroSCORE to predict mid-term survival following cardiac surgery. METHODS: We analysed prospectively collected data from all patients undergoing cardiac surgery in an urban tertiary cardiac centre over a 6-year period. All-cause mortality following cardiac surgery was determined via Office of National Statistics data...
October 2015: Interactive Cardiovascular and Thoracic Surgery
Mansour Jammal, Peter Milano, Renzo Cardenas, Thomas Mailhot, Diku Mandavia, Phillips Perera
Right heart thrombus (RHT) is a life-threatening diagnosis that is rarely made in the emergency department (ED), but with the increasing use of focused cardiac ultrasound (FocUS), more of these cases may be identified in a timely fashion. We present a case of an ill-appearing patient who had an immediate change in management due to the visualization of RHT soon after arrival to the ED. The diagnosis was confirmed after a cardiology-performed ultrasound (US). This case illustrates the value of the recognition of RHT on FocUS and how US protocols designed for the evaluation of shock and shortness of breath may potentially be expanded to patients in a 'compensated' or 'pre-shock' state to expedite the correct diagnosis and to facilitate more timely management...
2015: Critical Ultrasound Journal
Seongseok Yun, Nicole D Vincelette, Iyad Mansour, Dana Hariri, Sara Motamed
Metastatic cutaneous melanoma has poor prognosis with 2-year survival rate of 10-20%. Melanoma cells express various antigens including gp100, melanoma antigen recognized by T cells 1 (MART-1), and tyrosinase, which can induce immune-mediated anticancer response via T cell activation. Cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) is an immune check point molecule that negatively regulates T cell activation and proliferation. Accordingly, recent phase III clinical trials demonstrated significant survival benefit with ipilimumab, a human monoclonal antibody (IgG1) that blocks the interaction of CTLA-4 with its ligands...
2015: Case Reports in Oncological Medicine
Rami Doukky, Adebayo Olusanya, Raj Vashistha, Abhimanyu Saini, Ibtihaj Fughhi, Khaled Mansour, Abiy Nigatu, Kara Confer, Shannon A Sims
BACKGROUND: The diagnostic and prognostic value of regadenoson-induced ST-segment depression (ST↓) is not defined. Due to the low incidence of ST↓ ≥1.0 mm with vasodilator stress, a lower threshold to define ischemic ECG response may provide improved clinical utility. METHODS: We conducted a retrospective cohort study of patients who underwent regadenoson-stress SPECT myocardial perfusion imaging (MPI) followed by coronary angiography within 6 months. Ischemic ST↓ was defined as ≥0...
August 2015: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Vamsi Kota, Amber Clemmons, Arati Chand, Josh Simmons, Joshua Mansour, Ravindra Kolhe, Anand Jillella
BACKGROUND: Acute promyelocytic leukemia (APL) is a highly curable malignancy. However, 30% of patients die during therapy induction from bleeding, differentiation syndrome (DS), and/or infection. Recommendations suggest that congestive heart failure (CHF) is a presenting feature of DS. OBJECTIVE: To assess the incidence of CHF during induction in patients with APL. METHODS: A retrospective chart review was performed of patients diagnosed with APL from December 2004 to July 2013 and managed at Georgia Regents University Cancer Center...
November 2014: Journal of Community and Supportive Oncology
Mohammed Quttainah, Reem Al-Hejailan, Soad Saleh, Ranjit Parhar, Walter Conca, Bernard Bulwer, Narain Moorjani, Pedro Catarino, Raafat Elsayed, Mohammed Shoukri, Mansour AlJufan, Maie AlShahid, Abderrahman Ouban, Zohair Al-Halees, Stephen Westaby, Kate Collison, Futwan Al-Mohanna
BACKGROUND: The molecular mechanisms underlying the geometrical changes of the left ventricle during the progression to heart failure and recovery are not well defined. OBJECTIVE: Here we investigate the involvement of matrixins and cardiokines in an ovine model of pressure-induced left ventricular failure (LVF). METHODS: Fifteen sheep underwent supracoronary aortic banding with an inflatable cuff. A controlled and progressive increase of LV pressure was monitored echocardiographically...
2015: International Journal of Cardiology
Kylie Venardos, Kirstie A De Jong, Mansour Elkamie, Timothy Connor, Sean L McGee
The development of diabetic cardiomyopathy is a key contributor to heart failure and mortality in obesity and type 2 diabetes (T2D). Current therapeutic interventions for T2D have limited impact on the development of diabetic cardiomyopathy. Clearly, new therapies are urgently needed. A potential therapeutic target is protein kinase D (PKD), which is activated by metabolic insults and implicated in the regulation of cardiac metabolism, contractility and hypertrophy. We therefore hypothesised that PKD inhibition would enhance cardiac function in T2D mice...
2015: PloS One
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