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https://www.readbyqxmd.com/read/29910056/rationale-and-design-of-the-seneca-stem-cell-injection-in-cancer-survivors-trial
#1
Roberto Bolli, Joshua M Hare, Timothy D Henry, Carrie G Lenneman, Keith L March, Kathy Miller, Carl J Pepine, Emerson C Perin, Jay H Traverse, James T Willerson, Phillip C Yang, Adrian P Gee, João A Lima, Lem Moyé, Rachel W Vojvodic, Shelly L Sayre, Judy Bettencourt, Michelle Cohen, Ray F Ebert, Robert D Simari
OBJECTIVES: SENECA (StEm cell iNjECtion in cAncer survivors) is a phase I, randomized, double-blind, placebo-controlled study to evaluate the safety and feasibility of delivering allogeneic mesenchymal stromal cells (allo-MSCs) transendocardially in subjects with anthracycline-induced cardiomyopathy (AIC). BACKGROUND: AIC is an incurable and often fatal syndrome, with a prognosis worse than that of ischemic or nonischemic cardiomyopathy. Recently, cell therapy with MSCs has emerged as a promising new approach to repair damaged myocardium...
July 2018: American Heart Journal
https://www.readbyqxmd.com/read/29884521/nonaneurysmal-pseudo-subarachnoid-hemorrhage-computed-tomography-patterns-challenges-in-an-acute-decision-making-heuristics
#2
Tasneem F Hasan, Walter Duarte, Oluwaseun O Akinduro, Eric D Goldstein, Rebecca Hurst, Neil Haranhalli, David A Miller, Robert E Wharen, Rabih G Tawk, William D Freeman
BACKGROUND: Acute aneurysmal subarachnoid hemorrhage (SAH) is a medical and neurosurgical emergency from ruptured brain aneurysm. Aneurysmal SAH is identified on brain computed tomography (CT) as increased density of basal cisterns and subarachnoid spaces from acute blood products. Aneurysmal SAH-like pattern on CT appears as an optical illusion effect of hypodense brain parenchyma and/or hyperdense surrounding cerebral cisterns and blood vessels termed as "pseudo-subarachnoid hemorrhage" (pseudo-SAH)...
June 5, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29863912/cardiac-metabolic-effects-of-k-na-1-2-channel-deletion-and-evidence-for-its-mitochondrial-localization
#3
Charles O Smith, Yves T Wang, Sergiy M Nadtochiy, James H Miller, Elizabeth A Jonas, Robert T Dirksen, Keith Nehrke, Paul S Brookes
Controversy surrounds the molecular identity of mitochondrial K+ channels that are important for protection against cardiac ischemia-reperfusion injury. Although KNa 1.2 (sodium-activated potassium channel encoded by Kcn2) is necessary for cardioprotection by volatile anesthetics, electrophysiological evidence for a channel of this type in mitochondria is lacking. The endogenous physiological role of a potential mito-KNa 1.2 channel is also unclear. In this study, single channel patch-clamp of 27 independent cardiac mitochondrial inner membrane (mitoplast) preparations from wild-type (WT) mice yielded 6 channels matching the known ion sensitivity, ion selectivity, pharmacology, and conductance properties of KNa 1...
June 4, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29847793/accumulation-of-succinate-in-cardiac-ischemia-primarily-occurs-via-canonical-krebs-cycle-activity
#4
Jimmy Zhang, Yves T Wang, James H Miller, Mary M Day, Joshua C Munger, Paul S Brookes
Succinate accumulates during ischemia, and its oxidation at reperfusion drives injury. The mechanism of ischemic succinate accumulation is controversial and is proposed to involve reversal of mitochondrial complex II. Herein, using stable-isotope-resolved metabolomics, we demonstrate that complex II reversal is possible in hypoxic mitochondria but is not the primary succinate source in hypoxic cardiomyocytes or ischemic hearts. Rather, in these intact systems succinate primarily originates from canonical Krebs cycle activity, partly supported by aminotransferase anaplerosis and glycolysis from glycogen...
May 29, 2018: Cell Reports
https://www.readbyqxmd.com/read/29846989/arrhythmia-specific-settings-for-automated-high-density-mapping-a-multicenter-experience
#5
Philipp Sommer, Jean-Paul Albenque, Vincent van Driel, Bertrand Pierre, Claudio Tondo, Franz Xaver Roithinger, Hervé Poty, Amber Miller, Paolo Della Bella
BACKGROUND: Advancements in electrophysiology 3D mapping systems facilitate the broadening scope of electrophysiology study and catheter ablation to treat complex arrhythmias. While electroanatomical mapping systems have default settings available for a variety of mapping parameters, significant operator customization driven by arrhythmia type and experience can occur. However, multicenter comprehensive reporting of customized mapping settings is lacking. METHODS: In this prospective, multicenter observational registry, subjects with cardiac arrhythmias underwent electrophysiology study and ablation procedure using the EnSite Precision™ electroanatomical mapping system per standard of care, and associated automated mapping thresholds and procedural characteristics were observed...
May 30, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29844748/pericardial-rupture-with-intermittent-cardiac-luxation
#6
Dominick A Motto, Srikanth Kurapati, Daniela C Atencio, Margaret A Miller, Kurt R Stahlfeld
No abstract text is available yet for this article.
April 2018: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/29787864/the-neonatal-brain-in-critical-congenital-heart-disease-insights-and-future-directions
#7
REVIEW
Shabnam Peyvandi, Beatrice Latal, Steven P Miller, Patrick S McQuillen
Neurodevelopmental outcomes are impaired in survivors of critical congenital heart disease (CHD) in several developmental domains including motor, cognitive and sensory outcomes. These deficits can extend into the adolescent and early adulthood years. The cause of these neurodevelopmental impairments is multi-factorial and includes patient specific risk factors, cardiac anatomy and physiology as well as brain changes seen on MRI. Advances in imaging techniques have identified delayed brain development in the neonate with critical CHD as well as acquired brain injury...
May 19, 2018: NeuroImage
https://www.readbyqxmd.com/read/29768320/monocyte-chemoattractant-protein-1-as-a-predictor-of-coronary-atherosclerosis-in-patients-receiving-coronary-angiography
#8
Simon A Mahler, Thomas C Register, Robert F Riley, Ralph B D'Agostino, Jason P Stopyra, Chadwick D Miller
BACKGROUND: Animal studies suggest that monocyte chemoattractant protein-1 (MCP-1) is a promising biomarker for coronary artery atherosclerosis (CAA), but human studies have been inconclusive. OBJECTIVE: To determine potential relationships between plasma MCP-1 and CAA in patients with acute chest pain. METHODS: A secondary analysis of 150 patients enrolled in emergency department chest pain risk stratification clinical investigations was conducted...
June 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29755033/impact-of-a-history-of-hypertension-in-pregnancy-on-later-diagnosis-of-atrial-fibrillation
#9
Dawn C Scantlebury, Andrea G Kattah, Tracey L Weissgerber, Sanket Agarwal, Michelle M Mielke, Amy L Weaver, Lisa E Vaughan, Stanislav Henkin, Katherine Zimmerman, Virginia M Miller, Wendy M White, Sharonne N Hayes, Vesna D Garovic
BACKGROUND: Atrial fibrillation/flutter (AF) produces significant morbidity in women and is typically attributed to cardiac remodeling from multiple causes, particularly hypertension. Hypertensive pregnancy disorders (HPDs) are associated with future hypertension and adverse cardiac remodeling. We evaluated whether women with AF were more likely to have experienced a HPD compared with those without. METHODS AND RESULTS: A nested case-control study was conducted within a cohort of 7566 women who had a live or stillbirth delivery in Olmsted County, Minnesota between 1976 and 1982...
May 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29753517/liberal-versus-restrictive-intravenous-fluid-therapy-for-early-septic-shock-rationale-for-a-randomized-trial
#10
Wesley H Self, Matthew W Semler, Rinaldo Bellomo, Samuel M Brown, Bennett P deBoisblanc, Matthew C Exline, Adit A Ginde, Colin K Grissom, David R Janz, Alan E Jones, Kathleen D Liu, Stephen P J Macdonald, Chadwick D Miller, Pauline K Park, Lora A Reineck, Todd W Rice, Jay S Steingrub, Daniel Talmor, Donald M Yealy, Ivor S Douglas, Nathan I Shapiro
Prompt intravenous fluid therapy is a fundamental treatment for patients with septic shock. However, the optimal approach for administering intravenous fluid in septic shock resuscitation is unknown. Two competing strategies are emerging: a liberal fluids approach, consisting of a larger volume of initial fluid (50 to 75 mL/kg [4 to 6 L in an 80-kg adult] during the first 6 hours) and later use of vasopressors, versus a restrictive fluids approach, consisting of a smaller volume of initial fluid (≤30 mL/kg [≤2 to 3 L]), with earlier reliance on vasopressor infusions to maintain blood pressure and perfusion...
May 9, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29749937/risk-of-collateral-lead-damage-in-percutaneous-cardiac-implantable-electronic-device-extraction
#11
Faris Khan, Gustaf Sverin, Ulrika Birgersdotter-Green, Jennifer P Miller, Gautam Lalani, Travis Pollema, Victor Pretorius
OBJECTIVES: This study sought to assess the risk of collateral lead damage during cardiac implantable electronic device extraction. BACKGROUND: With the increasing numbers of cardiovascular implantable electronic devices, there has been an increase in the number of percutaneous device and lead extractions. It is unknown how often collateral damage (defined as the need for unintended lead extraction, or loss of lead's integrity or dislodgement) occurs in the planned retained leads...
February 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29748956/neurobehavioral-evaluation-of-neonates-with-congenital-heart-disease-a-cohort-study
#12
Whitnee J Hogan, Sarah Winter, Nelangi M Pinto, Cindy Weng, Xiaoming Sheng, Elisabeth Conradt, Janine Wood, Michael D Puchalski, Lloyd Y Tani, Thomas A Miller
AIM: To describe neurobehavioral patterns in neonates with congenital heart disease (CHD). METHOD: A cohort study describing neurobehavioral performance of neonates with CHD requiring cardiac surgery. The neonates were evaluated preoperatively and postoperatively with the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) and scores were compared with published normative values. Clinical factors were obtained by chart review to assess their association with behavior...
May 10, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29746007/preterm-growth-restriction-and-bronchopulmonary-dysplasia-the-vascular-hypothesis-and-related-physiology
#13
Arvind Sehgal, Stella M Gwini, Samuel Menahem, Beth J Allison, Suzanne L Miller, Graeme R Polglase
KEY POINTS: Approximately 5-10% pregnancies are affected by fetal growth restriction. Preterm infants affected by fetal growth restriction have a higher incidence of bronchopulmonary dysplasia. This study is the first to measure pulmonary artery thickness and stiffness. It highlights that impaired vasculogenesis may be a contributory factor in the higher incidence of bronchopulmonary dysplasia in preterm growth restricted infants. The study addresses the mechanistic link between fetal programming and vascular architecture and mechanics...
May 10, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29735525/orthostatic-hypotension-and-risk-of-clinical-and-subclinical-cardiovascular-disease-in-middle-aged-adults
#14
Stephen P Juraschek, Natalie Daya, Lawrence J Appel, Edgar R Miller, John William McEvoy, Kunihiro Matsushita, Christie M Ballantyne, Elizabeth Selvin
BACKGROUND: Although orthostatic hypotension (OH) is a well-recognized manifestation of neuropathy and hypovolemia, its contribution to cardiovascular disease (CVD) risk is controversial. METHODS AND RESULTS: Participants with OH, defined as a decrease in blood pressure (systolic ≥20 mm Hg or diastolic ≥10 mm Hg) from the supine to standing position, were identified during the first visit of the ARIC (Atherosclerosis Risk in Communities) Study (1987-1989) within 2 minutes of standing...
May 7, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29734195/tenascin-x-congenital-adrenal-hyperplasia-and-the-cah-x-syndrome
#15
Walter L Miller, Deborah P Merke
Mutations of the CYP21A2 gene encoding adrenal 21-hydroxylase cause congenital adrenal hyperplasia (CAH). The CYP21A2 gene is partially overlapped by the TNXB gene, which encodes an extracellular matrix protein called Tenascin-X (TNX). Mutations affecting both alleles of TNXB cause a severe, autosomal recessive form of Ehlers-Danlos syndrome (EDS). Rarely, patients with severe, salt-wasting CAH have deletions of CYP21A2 that extend into TNXB, resulting in a "contiguous gene syndrome" consisting of CAH and EDS...
May 7, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29719225/a-potent-and-specific-cd38-inhibitor-ameliorates-age-related-metabolic-dysfunction-by-reversing-tissue-nad-decline
#16
Mariana G Tarragó, Claudia C S Chini, Karina S Kanamori, Gina M Warner, Ariel Caride, Guilherme C de Oliveira, Micaela Rud, Adrienne Samani, Kyaw Z Hein, Runqing Huang, Diana Jurk, Dong Seong Cho, James J Boslett, Jordan D Miller, Jay L Zweier, João F Passos, Jason D Doles, David J Becherer, Eduardo N Chini
Aging is characterized by the development of metabolic dysfunction and frailty. Recent studies show that a reduction in nicotinamide adenine dinucleotide (NAD+ ) is a key factor for the development of age-associated metabolic decline. We recently demonstrated that the NADase CD38 has a central role in age-related NAD+ decline. Here we show that a highly potent and specific thiazoloquin(az)olin(on)e CD38 inhibitor, 78c, reverses age-related NAD+ decline and improves several physiological and metabolic parameters of aging, including glucose tolerance, muscle function, exercise capacity, and cardiac function in mouse models of natural and accelerated aging...
May 1, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29708915/should-percussion-pacing-have-a-role-in-perioperative-advanced-cardiac-life-support-a-case-report
#17
Chris Giordano, Jordan Miller, Ilan Keidan
Percussion pacing involves using one's fist to repeatedly strike a patient's left sternal border in a rhythmic manner. The resulting increase in ventricular pressure can trigger myocardial depolarization and subsequent contraction. We describe the successful treatment of acute preoperative symptomatic sinus bradycardia with percussion pacing in a 63-year-old patient scheduled for placement of a gastric feeding tube after trauma involving spinal cord injury. Although no longer included in current advanced cardiovascular life support guidelines, percussion pacing may be a suitable alternative to chest compressions in multitrauma cases where the force of compressions could cause further complications...
May 1, 2018: A&A practice
https://www.readbyqxmd.com/read/29706893/determinants-of-isoform-specific-gating-kinetics-of-herg1-channel-combined-experimental-and-simulation-study
#18
Laura L Perissinotti, Pablo M De Biase, Jiqing Guo, Pei-Chi Yang, Miranda C Lee, Colleen E Clancy, Henry J Duff, Sergei Y Noskov
IKr is the rapidly activating component of the delayed rectifier potassium current, the ion current largely responsible for the repolarization of the cardiac action potential. Inherited forms of long QT syndrome (LQTS) (Lees-Miller et al., 1997) in humans are linked to functional modifications in the Kv11.1 (hERG) ion channel and potentially life threatening arrhythmias. There is little doubt now that hERG-related component of IKr in the heart depends on the tetrameric (homo- or hetero-) channels formed by two alternatively processed isoforms of hERG, termed hERG1a and hERG1b...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29661525/a-preliminary-study-of-left-ventricular-rotational-mechanics-in-children-with-noncompaction-cardiomyopathy-do-they-influence-ventricular-function
#19
Hythem M Nawaytou, Andrea E Montero, Putri Yubbu, Renzo J C Calderón-Anyosa, Tomoyuki Sato, Matthew J O'Connor, Kelley D Miller, Philip C Ursell, Julien I E Hoffman, Anirban Banerjee
BACKGROUND: Current diagnostic criteria for noncompaction cardiomyopathy (NCC) lack specificity, and the disease lacks prognostic indicators. Reverse apical rotation (RAR) with abnormal rotation of the cardiac apex in the same clockwise direction as the base has been described in adults with NCC. The aim of this study was to test the hypothesis that RAR might differentiate between symptomatic NCC and benign hypertrabeculations and might be associated with ventricular dysfunction. METHODS: Echocardiograms from 28 children with NCC without cardiac malformations were prospectively compared with those from 29 age-matched normal control subjects...
April 13, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29627073/stress-cognitive-appraisal-coping-and-event-free-survival-in-patients-with-heart-failure
#20
Abdullah S Alhurani, Rebecca Dekker, Muayyad Ahmad, Jennifer Miller, Khalil M Yousef, Basel Abdulqader, Ibrahim Salami, Terry A Lennie, David C Randall, Debra K Moser
OBJECTIVES: To describe self-reported stress level, cognitive appraisal and coping among patients with heart failure (HF), and to examine the association of cognitive appraisal and coping strategies with event-free survival. METHODS: This was a prospective, longitudinal, descriptive study of patients with chronic HF. Assessment of stress, cognitive appraisal, and coping was performed using Perceived Stress Scale, Cognitive Appraisal Health Scale, and Brief COPE scale, respectively...
May 2018: Heart & Lung: the Journal of Critical Care
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