keyword
https://read.qxmd.com/read/34157780/surveillance-imaging-during-first-remission-in-follicular-lymphoma-does-not-impact-overall-survival
#21
JOURNAL ARTICLE
Max L Goldman, Jimmy J Mao, Christopher S Strouse, Wanqi Chen, Manali Rupji, Zhengjia Chen, Matthew J Maurer, Oscar Calzada, Michael Churnetski, Christopher R Flowers, James R Cerhan, Brian K Link, Carrie A Thompson, Jonathon B Cohen
BACKGROUND: Although many patients with follicular lymphoma (FL) undergo routine radiographic surveillance during their first remission, no consensus exists on the modality, duration, frequency, or need for routine imaging studies. The authors retrospectively examined the effect of surveillance imaging on relapse detection and overall survival (OS) in patients with FL. METHODS: Patients with newly diagnosed FL who had a response to induction therapy were identified from the Lymphoid Malignancies Enterprise Architecture Database (LEAD) at Emory University and from the Molecular Epidemiology Resource (MER) of the University of Iowa/Mayo Clinic...
June 22, 2021: Cancer
https://read.qxmd.com/read/34087804/does-intrathecal-nicardipine-for-cerebral-vasospasm-following-subarachnoid-hemorrhage-correlate-with-reduced-delayed-cerebral-ischemia-a-retrospective-propensity-score-based-analysis
#22
JOURNAL ARTICLE
Ofer Sadan, Hannah Waddel, Reneé Moore, Chen Feng, Yajun Mei, David Pearce, Jacqueline Kraft, Cederic Pimentel, Subin Mathew, Feras Akbik, Pouya Ameli, Alexis Taylor, Lisa Danyluk, Kathleen S Martin, Krista Garner, Jennifer Kolenda, Amit Pujari, William Asbury, Blessing N R Jaja, R Loch Macdonald, C Michael Cawley, Daniel L Barrow, Owen Samuels
OBJECTIVE: Cerebral vasospasm and delayed cerebral ischemia (DCI) contribute to poor outcome following subarachnoid hemorrhage (SAH). With the paucity of effective treatments, the authors describe their experience with intrathecal (IT) nicardipine for this indication. METHODS: Patients admitted to the Emory University Hospital neuroscience ICU between 2012 and 2017 with nontraumatic SAH, either aneurysmal or idiopathic, were included in the analysis. Using a propensity-score model, this patient cohort was compared to patients in the Subarachnoid Hemorrhage International Trialists (SAHIT) repository who did not receive IT nicardipine...
January 1, 2022: Journal of Neurosurgery
https://read.qxmd.com/read/33931980/the-function-of-lncrnas-and-their-role-in-the-prediction-diagnosis-and-prognosis-of-lung-cancer
#23
REVIEW
Yu Chen, Emory Zitello, Rui Guo, Youping Deng
Lung cancer remains a major threat to human health. Low dose CT scan (LDCT) has become the main method of early screening for lung cancer due to the low sensitivity of chest X-ray. However, LDCT not only has a high false positive rate, but also entails risks of overdiagnosis and cumulative radiation exposure. In addition, cumulative radiation by LDCT screening and subsequent follow-up can increase the risk of lung cancer. Many studies have shown that long noncoding RNAs (lncRNAs) remain stable in blood, and profiling of blood has the advantages of being noninvasive, readily accessible and inexpensive...
April 2021: Clinical and Translational Medicine
https://read.qxmd.com/read/32902858/efficacy-and-safety-of-immune-checkpoint-blockade-in-self-identified-black-patients-with-advanced-non-small-cell-lung-cancer
#24
JOURNAL ARTICLE
Bassel Nazha, Subir Goyal, Zhengjia Chen, Anne Engelhart, Jennifer Wilkinson Carlisle, Tyler J Beardslee, Harpaul Gill, Levani Odikadze, Yuan Liu, Manoj K Mishra, Suresh S Ramalingam, Taofeek Kunle Owonikoko
BACKGROUND: To the authors' knowledge, race-based differences in efficacy for the treatment of patients with advanced non-small cell lung cancer (NSCLC) have not been studied to date due to the underrepresentation of patients of minority backgrounds in pivotal trials. In the current study, the authors examined real-world differences in outcome in a diverse patient population. METHODS: The authors retrospectively analyzed the clinical outcomes of patients with advanced NSCLC who were treated with single-agent immune checkpoint blockade (ICB) between 2013 and July 2018 at Winship Cancer Institute of Emory University in Atlanta, Georgia...
December 1, 2020: Cancer
https://read.qxmd.com/read/32469259/validation-of-the-three-item-skindex-mini-among-hidradenitis-suppurativa-patients-with-diverse-racial-backgrounds
#25
JOURNAL ARTICLE
Lauren A V Orenstein, Adaugo Amah, Fiona M Shaw, Chao Zhang, Robert A Swerlick, Suephy C Chen
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that severely impairs patients' quality of life (QoL). Instruments such as the 10-item Dermatology Life Quality Index and 16-item Skindex-16 have been used to assess QoL in HS; however, it is unknown whether the shorter 3-item Skindex-mini can also provide an accurate assessment of skin-related QoL in patients with HS. OBJECTIVES: The aim was to assess how well the Skindex-16 correlates with its shorter adaptation, the Skindex-mini, in capturing QoL among patients with HS...
May 29, 2020: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/32249882/surface-buckling-delamination-patterns-of-film-on-soft-spherical-substrates
#26
JOURNAL ARTICLE
Kanako Emori, Yusaku Saito, Akio Yonezu, Liangliang Zhu, Xiangbiao Liao, Xi Chen
This study aims to provide a fundamental understanding of the morphological transition of film buckling-delamination in an elastomeric bilayer spherical shell system. We developed an experimental system in which surface delamination buckles emerge because of biaxial compression of the elastomeric bilayer spherical shell driven by an air-pressured (pneumatic) device. A flat PDMS plate was first isotropically expanded and shaped into a hemisphere by air pressure. Subsequently, the hemisphere substrate was covered with a thin PDMS film...
April 6, 2020: Soft Matter
https://read.qxmd.com/read/31893406/clinical-and-statistical-considerations-when-assessing-oxygen-levels-in-tumors-illustrative-results-from-clinical-epr-oximetry-studies
#27
JOURNAL ARTICLE
A B Flood, P E Schaner, P Vaupel, B B Williams, B Gallez, E Y Chen, A Ali, T Liu, V H Lawson, W Schreiber, H M Swartz
The success of treatment for malignancies, especially those undergoing radiation therapy or chemotherapy, has long been recognized to depend on the degree of hypoxia in the tumor. In addition to the prognostic value of knowing the tumor's initial level of hypoxia, assessing the tumor oxygenation during standard therapy or oxygen-related treatments (such as breathing oxygen-enriched gas mixtures or taking drugs that can increase oxygen supply to tissues) can provide valuable data to improve the efficacy of treatments...
2020: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/30993654/evaluation-of-left-ventricular-volumes-and-ejection-fraction-by-99m-tc-mibi-gated-spect-and-18-f-fdg-gated-pet-in-patients-with-prior-myocardial-infarction
#28
JOURNAL ARTICLE
Yong Yao, Da-Wei Wang, Wei Fang, Yue-Qin Tian, Rui Shen, Xiao-Xin Sun, Feng Guo, Ke-Wei Chu, Chen Cui, Shi-Hua Zhao, Zuo-Xiang He
BACKGROUND: This study aimed to compare the accuracy of gated-SPECT (GSPECT) and gated-PET (GPET) in the assessment of left ventricular (LV) end-diastolic volumes (EDVs), end-systolic volumes (ESVs) and LV ejection fractions (LVEFs) among patients with prior myocardial infarction (MI). METHODS: One hundred and sixty-eight consecutive patients with MI who underwent GSPECT and GPET were included. Of them, 76 patients underwent CMR in addition to the two imaging modalities...
April 2021: Journal of Nuclear Cardiology
https://read.qxmd.com/read/30853232/the-thoracic-endovascular-aortic-repair-first-strategy-for-acute-type-a-dissection-with-mesenteric-malperfusion-initial-results-compared-with-conventional-algorithms
#29
JOURNAL ARTICLE
Bradley G Leshnower, W Brent Keeling, Yazan M Duwayri, William D Jordan, Edward P Chen
OBJECTIVE: Acute type A dissection with mesenteric malperfusion is a rare but lethal variant of aortic dissection. This study examines outcomes from various treatment algorithms. METHODS: A review from 2003 to 2017 of the Emory Aortic Database identified 34 patients who presented with acute type A dissection with mesenteric malperfusion. Outcomes from 4 different treatment strategies were analyzed: ascending aortic/arch replacement followed by laparotomy (n = 13), axillary-bifemoral artery bypass followed by ascending/arch replacement (n = 3); ascending/arch and concomitant antegrade thoracic endovascular aortic repair (TEVAR) (n = 5), and TEVAR followed by delayed ascending/arch replacement (TEVAR-1st) (n = 13)...
February 11, 2019: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/30741548/mos2-liquid-cell-electron-microscopy-through-clean-and-fast-polymer-free-mos2-transfer
#30
JOURNAL ARTICLE
Jiwoong Yang, Moon Kee Choi, Yuewen Sheng, Jaebong Jung, Karen C Bustillo, Tongxin Chen, Seung-Wuk Lee, Peter Ercius, Ji Hoon Kim, Jamie H Warner, Emory M Chan, Haimei Zheng
Two dimensional (2D) materials have found various applications because of their unique physical properties. For example, graphene has been used as the electron transparent membrane for liquid cell transmission electron microscopy (TEM) due to its high mechanical strength and flexibility, single-atom thickness, chemical inertness, etc. Here, we report using 2D MoS2 as a functional substrate as well as the membrane window for liquid cell TEM, which is enabled by our facile and polymer-free MoS2 transfer process...
February 11, 2019: Nano Letters
https://read.qxmd.com/read/30353872/distinguishing-true-progression-from-radionecrosis-after-stereotactic-radiation-therapy-for-brain-metastases-with-machine-learning-and-radiomics
#31
JOURNAL ARTICLE
Luke Peng, Vishwa Parekh, Peng Huang, Doris D Lin, Khadija Sheikh, Brock Baker, Talia Kirschbaum, Francesca Silvestri, Jessica Son, Adam Robinson, Ellen Huang, Heather Ames, Jimm Grimm, Linda Chen, Colette Shen, Michael Soike, Emory McTyre, Kristin Redmond, Michael Lim, Junghoon Lee, Michael A Jacobs, Lawrence Kleinberg
PURPOSE: Treatment effect or radiation necrosis after stereotactic radiosurgery (SRS) for brain metastases is a common phenomenon often indistinguishable from true progression. Radiomics is an emerging field that promises to improve on conventional imaging. In this study, we sought to apply a radiomics-based prediction model to the problem of diagnosing treatment effect after SRS. METHODS AND MATERIALS: We included patients in the Johns Hopkins Health System who were treated with SRS for brain metastases who subsequently underwent resection for symptomatic growth...
November 15, 2018: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/30292842/predictors-of-failure-of-medical-management-in-uncomplicated-type-b-aortic-dissection
#32
JOURNAL ARTICLE
Xiaoying Lou, Yazan M Duwayri, Edward P Chen, William D Jordan, Jessica Forcillo, Carl A Zehner, Bradley G Leshnower
BACKGROUND: Optimal medical therapy (OMT) for uncomplicated type B aortic dissection (uTBAD) provides excellent short-term outcomes but is associated with a high incidence of failure. This study identified predictors of aortic intervention and mortality in uTBAD patients undergoing OMT. METHODS: A retrospective review of the Emory University School of Medicine aortic database identified 314 uTBAD patients undergoing OMT from 2000 to 2016. Two hundred sixty-three (84%) patients had imaging at presentation analyzed for maximum aortic diameters (ADs), false lumen (FL) status, and visceral vessel perfusion...
February 2019: Annals of Thoracic Surgery
https://read.qxmd.com/read/30292615/the-distance-of-the-primary-intimal-tear-from-the-left-subclavian-artery-predicts-aortic-growth-in-uncomplicated-type-b-aortic-dissection
#33
JOURNAL ARTICLE
Jesse A Codner, Xiaoying Lou, Yazan M Duwayri, Edward P Chen, Jose N Binongo, Rena Moon, William D Jordan, Bradley G Leshnower
OBJECTIVE: Controversy exists about the optimal treatment of acute uncomplicated type B aortic dissection (auTBAD). Optimal medical therapy (OMT) provides excellent short-term outcomes, but long-term results are poor. Ideally, auTBAD patients who will fail to respond to OMT in the chronic phase could be identified and undergo thoracic endovascular aortic repair. The purpose of this study was to identify radiographic predictors of auTBAD patients who will fail to respond to OMT. METHODS: A review of the Emory aortic database from 2000 to 2017 identified 320 auTBAD patients initially treated with OMT...
March 2019: Journal of Vascular Surgery
https://read.qxmd.com/read/30262410/patient-reported-health-related-quality-of-life-outcomes-after-hdr-brachytherapy-between-small-60-cc-and-large-%C3%A2-60-cc-prostate-glands
#34
JOURNAL ARTICLE
Robert H Press, Tiffany M Morgan, Patrick K Cutrell, Chao Zhang, Zhengjia Chen, Sara Rahnema, Martin Sanda, John Pattaras, Pretesh Patel, Ashesh B Jani, Peter J Rossi
PURPOSE: Patients with large prostate glands are underrepresented in clinical trials incorporating brachytherapy due to concerns for excessive toxicity. We sought to compare health-related quality of life (HRQOL) outcomes between small (<60 cc) and large (≥60 cc) prostates treated with high-dose-rate brachytherapy (HDR-B). METHODS AND MATERIALS: One hundred thirty patients at Emory University were treated with HDR-B monotherapy (n = 75) or HDR-B in combination with external beam radiation therapy (n = 55)...
January 2019: Brachytherapy
https://read.qxmd.com/read/30219407/pulmonary-venous-waveforms-predict-rehospitalization-and-mortality-after-percutaneous-mitral-valve-repair
#35
JOURNAL ARTICLE
Frank E Corrigan, John H Chen, Aneel Maini, John C Lisko, Lucia Alvarez, Norihiko Kamioka, Shawn Reginauld, Patrick T Gleason, Jose F Condado, Jane Wenjing Wei, Jose N Binongo, Patricia Keegan, Sharon Howell, Vinod H Thourani, Peter C Block, Stephen D Clements, Vasilis C Babaliaros, Stamatios Lerakis
OBJECTIVES: In this study, the authors hypothesized that intraprocedural improvement of pulmonary venous (PV) waveforms are predictive of improved outcomes. In this report, they analyzed intraprocedural invasive and echocardiographic changes with respect to rehospitalization and mortality. BACKGROUND: The effects of hemodynamic changes during percutaneous mitral valve repair (PMVR) with MitraClip (Abbott Vascular, Santa Clara, California) are incompletely characterized...
October 2019: JACC. Cardiovascular Imaging
https://read.qxmd.com/read/29553492/fabrication-of-spherical-and-worm-shaped-micellar-nanocrystals-by-combining-electrospray-self-assembly-and-solvent-based-structure-control
#36
JOURNAL ARTICLE
Xinyi Ding, Yuxiang Sun, Yanming Chen, Wanchuan Ding, Steven Emory, Tianhao Li, Zixing Xu, Ning Han, Jun Wang, Gang Ruan
Micellar nanocrystals (micelles with encapsulated nanocrystals) have become an emerging major class of nanobiomaterials. We describe a method of fabricating micellar nanocrystals based on combining top-down electrospray, bottom-up self-assembly, and solvent-based structure control. This method involves first using electrospray to generate uniform ultrafine liquid droplets, each of which functions as a micro-reactor in which self-assembly reaction occurs forming micellar nanocrystals, with the structures (micelle shape and nanocrystal encapsulation) controlled by the organic solvent used...
February 11, 2018: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/29469713/video-based-education-about-systemic-corticosteroids-enhances-patient-knowledge-more-than-verbal-education-a-randomized-controlled-trial
#37
RANDOMIZED CONTROLLED TRIAL
Christina M Correnti, Suephy C Chen, Benjamin K Stoff
BACKGROUND: Video-based patient education about long-term systemic corticosteroid treatment has not been assessed. OBJECTIVE: To compare video-based versus verbal education in patient knowledge gained and satisfaction. METHODS: English-speaking adults (≥18 years) were recruited from March-August 2013 from medical dermatology clinics. Study provider clinics were the unit of randomization. Verbal subjects heard a script based on the standard discussions of two top systemic corticosteroid prescribers at Emory...
September 15, 2017: Dermatology Online Journal
https://read.qxmd.com/read/29372601/comparing-the-neuropsychological-profiles-of-mild-dementia-with-lewy-bodies-and-mild-alzheimer-s-disease
#38
COMPARATIVE STUDY
Yan Xu, Keliang Chen, Qianhua Zhao, Qihao Guo
BACKGROUND: The present study was conducted to detect neuropsychological differences and to identify discriminators between mild dementia with L ewy bodies (DLB ) and mild A lzheimer's disease (AD ). METHODS: The present study included 37 mild DLB patients, 48 mild AD patients, and 80 healthy elderly individuals. A comprehensive battery of neuropsychological tests was administrated to assess their cognitive function. Linear stepwise discriminant analysis was used to identify the neuropsychological measures with values that could differentiate between mild DLB and mild AD ...
January 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://read.qxmd.com/read/28844774/disseminated-cryptococcal-osteomyelitis-to-the-hand-in-an-immunosuppressed-lymphoma-patient
#39
JOURNAL ARTICLE
Wayne A Chen, Cynthia L Emory, Benjamin R Graves
Fungal osteomyelitis of the hand is rare with limited evidence-based literature to guide diagnosis and management. We report a case of disseminated cryptococcal osteomyelitis in the middle phalanx from a pulmonary fungal infection in a patient with a history of lymphoplasmacytic lymphoma. Although rare, cryptococcosis should be considered in the differential diagnosis of aggressive lytic lesions with bone pain and associated large soft tissue masses, especially in the immunosuppressed host.
March 2018: Journal of Hand Surgery
https://read.qxmd.com/read/28811003/the-impact-of-thoracic-endovascular-aortic-repair-on-long-term-survival-in-type-b-aortic-dissection
#40
JOURNAL ARTICLE
Xiaoying Lou, Edward P Chen, Yazan M Duwayri, Ravi K Veeraswamy, William D Jordan, Carl A Zehner, Bradley G Leshnower
BACKGROUND: Currently, optimal medical therapy is first-line therapy for uncomplicated acute type B aortic dissection (aTBAD) despite poor long-term outcomes. This study examines the impact of thoracic endovascular aortic repair (TEVAR) in the acute and chronic phases on short-term and long-term survival of patients presenting with aTBAD. METHODS: A review of the Emory aortic database from 2000 to 2016 identified 398 patients diagnosed with aTBAD. At index hospitalization, complicated patients underwent TEVAR (aTEVAR [thoracic endovascular aortic repair in the acute phase], n = 80) and uncomplicated patients received optimal medical therapy (n = 318)...
January 2018: Annals of Thoracic Surgery
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