Ofer Sadan, Hannah Waddel, Reneé Moore, Chen Feng, Yajun Mei, David Pearce, Jacqueline Kraft, Cederic Pimentel, Subin Mathew, Feras Akbik, Pouya Ameli, Alexis Taylor, Lisa Danyluk, Kathleen S Martin, Krista Garner, Jennifer Kolenda, Amit Pujari, William Asbury, Blessing N R Jaja, R Loch Macdonald, C Michael Cawley, Daniel L Barrow, Owen Samuels
OBJECTIVE: Cerebral vasospasm and delayed cerebral ischemia (DCI) contribute to poor outcome following subarachnoid hemorrhage (SAH). With the paucity of effective treatments, the authors describe their experience with intrathecal (IT) nicardipine for this indication. METHODS: Patients admitted to the Emory University Hospital neuroscience ICU between 2012 and 2017 with nontraumatic SAH, either aneurysmal or idiopathic, were included in the analysis. Using a propensity-score model, this patient cohort was compared to patients in the Subarachnoid Hemorrhage International Trialists (SAHIT) repository who did not receive IT nicardipine...
January 1, 2022: Journal of Neurosurgery