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Chen Emory

Xinyi Ding, Yuxiang Sun, Yanming Chen, Wanchuan Ding, Steven Emory, Tianhao Li, Zixing Xu, Ning Han, Jun Wang, Gang Ruan
Micellar nanocrystals (micelles with encapsulated nanocrystals) have become an emerging major class of nanobiomaterials. We describe a method of fabricating micellar nanocrystals based on combining top-down electrospray, bottom-up self-assembly, and solvent-based structure control. This method involves first using electrospray to generate uniform ultrafine liquid droplets, each of which functions as a micro-reactor in which self-assembly reaction occurs forming micellar nanocrystals, with the structures (micelle shape and nanocrystal encapsulation) controlled by the organic solvent used...
February 11, 2018: Journal of Visualized Experiments: JoVE
Christina M Correnti, Suephy C Chen, Benjamin K Stoff
BACKGROUND: Video-based patient education about long-term systemic corticosteroid treatment has not been assessed. OBJECTIVE: To compare video-based versus verbal education in patient knowledge gained and satisfaction. METHODS: English-speaking adults (≥18 years) were recruited from March-August 2013 from medical dermatology clinics. Study provider clinics were the unit of randomization. Verbal subjects heard a script based on the standard discussions of two top systemic corticosteroid prescribers at Emory...
September 15, 2017: Dermatology Online Journal
Yan Xu, Keliang Chen, Qianhua Zhao, Qihao Guo
BACKGROUND: The present study was conducted to detect neuropsychological differences and to identify discriminators between mild dementia with L ewy bodies (DLB ) and mild A lzheimer's disease (AD ). METHODS: The present study included 37 mild DLB patients, 48 mild AD patients, and 80 healthy elderly individuals. A comprehensive battery of neuropsychological tests was administrated to assess their cognitive function. Linear stepwise discriminant analysis was used to identify the neuropsychological measures with values that could differentiate between mild DLB and mild AD ...
January 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
Wayne A Chen, Cynthia L Emory, Benjamin R Graves
Fungal osteomyelitis of the hand is rare with limited evidence-based literature to guide diagnosis and management. We report a case of disseminated cryptococcal osteomyelitis in the middle phalanx from a pulmonary fungal infection in a patient with a history of lymphoplasmacytic lymphoma. Although rare, cryptococcosis should be considered in the differential diagnosis of aggressive lytic lesions with bone pain and associated large soft tissue masses, especially in the immunosuppressed host.
March 2018: Journal of Hand Surgery
Xiaoying Lou, Edward P Chen, Yazan M Duwayri, Ravi K Veeraswamy, William D Jordan, Carl A Zehner, Bradley G Leshnower
BACKGROUND: Currently, optimal medical therapy is first-line therapy for uncomplicated acute type B aortic dissection (aTBAD) despite poor long-term outcomes. This study examines the impact of thoracic endovascular aortic repair (TEVAR) in the acute and chronic phases on short-term and long-term survival of patients presenting with aTBAD. METHODS: A review of the Emory aortic database from 2000 to 2016 identified 398 patients diagnosed with aTBAD. At index hospitalization, complicated patients underwent TEVAR (aTEVAR [thoracic endovascular aortic repair in the acute phase], n = 80) and uncomplicated patients received optimal medical therapy (n = 318)...
January 2018: Annals of Thoracic Surgery
Jose F Condado, Hanna A Jensen, Aneel Maini, Yi-An Ko, Mohammad H Rajaei, Lillian L Tsai, Chandan Devireddy, Bradley Leshnower, Kreton Mavromatis, Eric L Sarin, James Stewart, Robert A Guyton, Vasilis Babaliaros, Edward P Chen, Michael Halkos, Amy Simone, Patricia Keegan, Peter C Block, Vinod H Thourani
BACKGROUND: Screening for internal carotid artery stenosis (ICAS) with Doppler ultrasound is commonly used before cardiovascular surgery. Nevertheless, the relationship between ICAS and procedure-related stroke in isolated aortic valve replacement is unclear. METHODS: We retrospectively reviewed patients with artery stenosis who underwent ICAS screening before surgical (SAVR) or transcatheter aortic valve replacement (TAVR) between January 2007 and August 2014. Logistic regression models were used to determine the relation between post-procedure stroke and total (sum of left and right ICAS) and maximal unilateral ICAS...
March 2017: Annals of Thoracic Surgery
Richard R Orlandi, Todd T Kingdom, Peter H Hwang, Timothy L Smith, Jeremiah A Alt, Fuad M Baroody, Pete S Batra, Manuel Bernal-Sprekelsen, Neil Bhattacharyya, Rakesh K Chandra, Alexander Chiu, Martin J Citardi, Noam A Cohen, John DelGaudio, Martin Desrosiers, Hun-Jong Dhong, Richard Douglas, Berrylin Ferguson, Wytske J Fokkens, Christos Georgalas, Andrew Goldberg, Jan Gosepath, Daniel L Hamilos, Joseph K Han, Richard Harvey, Peter Hellings, Claire Hopkins, Roger Jankowski, Amin R Javer, Robert Kern, Stilianos Kountakis, Marek L Kowalski, Andrew Lane, Donald C Lanza, Richard Lebowitz, Heung-Man Lee, Sandra Y Lin, Valerie Lund, Amber Luong, Wolf Mann, Bradley F Marple, Kevin C McMains, Ralph Metson, Robert Naclerio, Jayakar V Nayak, Nobuyoshi Otori, James N Palmer, Sanjay R Parikh, Desiderio Passali, Anju Peters, Jay Piccirillo, David M Poetker, Alkis J Psaltis, Hassan H Ramadan, Vijay R Ramakrishnan, Herbert Riechelmann, Hwan-Jung Roh, Luke Rudmik, Raymond Sacks, Rodney J Schlosser, Brent A Senior, Raj Sindwani, James A Stankiewicz, Michael Stewart, Bruce K Tan, Elina Toskala, Richard Voegels, De Yun Wang, Erik K Weitzel, Sarah Wise, Bradford A Woodworth, Peter-John Wormald, Erin D Wright, Bing Zhou, David W Kennedy
BACKGROUND: The body of knowledge regarding rhinosinusitis(RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). METHODS: Evidence-based reviews with recommendations(EBRRs) were developed for scores of topics, using previously reported methodology...
February 2016: International Forum of Allergy & Rhinology
Shih-Chuan Tsai, Yu-Cheng Chang, Kuo-Feng Chiang, Wan-Yu Lin, Jin-Long Huang, Guang-Uei Hung, Chia-Hung Kao, Ji Chen
For patients with coronary artery disease, larger scar burdens are associated with higher risk of ventricular arrhythmia. Left ventricular (LV) dyssynchrony is associated with increased risk of sudden cardiac death in patients with heart failure. The purpose of this study was to assess the values of LV dyssynchrony and myocardial scar assessed by myocardial perfusion SPECT (MPS) in predicting the development of ventricular arrhythmia in ischemic cardiomyopathy. Twenty-two patients (16 males, mean age: 66 ± 13) with irreversible ischemic cardiomyopathy received cardiac resynchronization therapy (CRT) for at least 12 months were enrolled for MPS...
February 2016: Medicine (Baltimore)
Li Chen, Zhaohui S Qin
UNLABELLED: Genome-wide association studies (GWASs) have successfully identified many sequence variants that are significantly associated with common diseases and traits. Tens of thousands of such trait-associated SNPs have already been cataloged, which we believe form a great resource for genomic research. Recent studies have demonstrated that the collection of trait-associated SNPs can be exploited to indicate whether a given genomic interval or intervals are likely to be functionally connected with certain phenotypes or diseases...
April 15, 2016: Bioinformatics
Jay Chauhan, Shen-En Chen, Katherine J Fenstermacher, Aurash Naser-Tavakolian, Tali Reingewertz, Rosene Salmo, Christian Lee, Emori Williams, Mithun Raje, Eric Sundberg, Jeffrey J DeStefano, Ernesto Freire, Steven Fletcher
Small-molecule mimetics of the β-hairpin flap of HIV-1 protease (HIV-1 PR) were designed based on a 1,4-benzodiazepine scaffold as a strategy to interfere with the flap-flap protein-protein interaction, which functions as a gated mechanism to control access to the active site. Michaelis-Menten kinetics suggested our small-molecules are competitive inhibitors, which indicates the mode of inhibition is through binding the active site or sterically blocking access to the active site and preventing flap closure, as designed...
November 1, 2015: Bioorganic & Medicinal Chemistry
Bradley G Leshnower, Vinod H Thourani, Michael E Halkos, Eric L Sarin, William B Keeling, Mark J Lamias, Robert A Guyton, Edward P Chen
BACKGROUND: Despite improved results with surgical therapy for acute type A aortic dissection (ATAAD), there remains a lack of consensus regarding the optimal method of cerebral protection and circulation management during ATAAD. The purpose of this study is to determine whether in the setting of antegrade cerebral perfusion, moderate hypothermic circulatory arrest (MHCA) provides equivalent cerebral and visceral protection as deep hypothermic circulatory arrest (DHCA) for patients undergoing emergent ATAAD repair...
November 2015: Annals of Thoracic Surgery
Po-Nien Hou, Shih-Chuan Tsai, Wan-Yu Lin, Chien-Ming Cheng, Kuo-Feng Chiang, Yu-Cheng Chang, Jin-Long Huang, Guang-Uei Hung, Shih-Ann Chen, Ji Chen
BACKGROUND: Ventricular arrhythmia is the major cause of sudden cardiac death for patients with heart failure, including those receiving implantation of cardiac resynchronization therapy (CRT). The purpose of this study was to assess the value of myocardial perfusion SPECT (MPS) in predicting ventricular arrhythmia for patients with CRT. METHODS AND METHODS: Fifty-one patients (35 males, mean age 64 ± 12 years) who had received CRT for at least 6 months were enrolled for resting gated MPS...
November 2015: Annals of Nuclear Medicine
Walid L Shaib, Ludmila Katherine Martin, Minsing Choi, Zhengjia Chen, Kavya Krishna, Sungjin Kim, Edith Brutcher, Charles Staley, Shishir K Maithel, Philip Philip, Sherif Abdel-Misih, Tanios S Bekaii-Saab, Bassel F El-Rayes
PURPOSE: Appendiceal mucinous neoplasms (AMN) are a rare heterogeneous group of diseases. In the absence of randomized trials, AMN management is controversial. The goal of this study was to evaluate the impact of hyperthermic intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery on survival in AMN patients. PATIENTS AND METHODS: Patient data including demographics, pathology, type of therapy, and outcomes were collected from Emory University, the Ohio State University, and Wayne State University databases...
August 2015: Oncologist
Walid Shaib, Kavya Krishna, Sungjin Kim, Michael Goodman, Jonathan Rock, Zhengjia Chen, Edith Brutcher, Charles Iii Staley, Shishir K Maithel, Samih Abdel-Missih, Bassel F El-Rayes, Tanios Bekaii-Saab
PURPOSE: Appendiceal tumors are a heterogeneous group of diseases that include typical neuroendocrine tumors (TNET), goblet cell carcinoids (GCC), and atypical GCC. Atypical GCC are classified into signet-ring cell cancers (SRCC) and poorly differentiated appendiceal adenocarcinoids. The prognosis and management of these diseases is unclear because there are no prospective studies. The aim of this study is to assess the characteristics and outcome of appendiceal TNET, GCC, and SRCC patients...
April 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Li Chen, Chi Wang, Zhaohui S Qin, Hao Wu
MOTIVATION: ChIP-seq is a powerful technology to measure the protein binding or histone modification strength in the whole genome scale. Although there are a number of methods available for single ChIP-seq data analysis (e.g. 'peak detection'), rigorous statistical method for quantitative comparison of multiple ChIP-seq datasets with the considerations of data from control experiment, signal to noise ratios, biological variations and multiple-factor experimental designs is under-developed...
June 15, 2015: Bioinformatics
Eric R Kallwitz, Martha L Daviglus, Matthew A Allison, Kristen T Emory, Lihui Zhao, Mark H Kuniholm, Jinsong Chen, Natalia Gouskova, Amber Pirzada, Gregory A Talavera, Marston E Youngblood, Scott J Cotler
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) was shown to disproportionally affect Hispanic persons. We examined the prevalence of suspected NAFLD in Hispanic/Latino persons with diverse backgrounds. METHODS: We studied the prevalence of suspected NAFLD among 12,133 persons included in the Hispanic Community Health Study/Study of Latinos. We collected data on levels of aminotransferase, metabolic syndrome (defined by National Cholesterol Education Program-Adult Treatment Panel III guidelines), demographics, and health behaviors...
March 2015: Clinical Gastroenterology and Hepatology
Naif A M Almontashiri, Ragnar O Vilmundarson, Nima Ghasemzadeh, Sonny Dandona, Robert Roberts, Arshed A Quyyumi, Hsiao-Huei Chen, Alexandre F R Stewart
OBJECTIVE: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that promotes degradation of the low density lipoprotein (LDL) receptor. Mutations that block PCSK9 secretion reduce LDL-cholesterol and the incidence of myocardial infarction (MI). However, it remains unclear whether elevated plasma PCSK9 associates with coronary atherosclerosis (CAD) or more directly with rupture of the plaque causing MI. METHODS AND RESULTS: Plasma PCSK9 was measured by ELISA in 645 angiographically defined controls (<30% coronary stenosis) and 3,273 cases of CAD (>50% stenosis in a major coronary artery) from the Ottawa Heart Genomics Study...
2014: PloS One
Tom C Nguyen, Vasilis C Babaliaros, Seyed Amirhossein Razavi, Patrick D Kilgo, Chandan M Devireddy, Brad G Leshnower, Kreton Mavromatis, Robert A Guyton, Mihir Kanitkar, Stam Lerakis, John Merlino, Edward P Chen, Vinod H Thourani
BACKGROUND: An increasing number of patients with prior coronary artery bypass grafting (CABG) now present with severe aortic stenosis. The proposed benefit of surgical (SAVR) vs transcatheter aortic valve replacement (TAVR) is unknown. The objective of this study was to compare short-term and midterm outcomes of patients undergoing isolated SAVR vs TAVR in those with prior CABG. METHODS: A retrospective analysis was performed of 255 patients who underwent isolated SAVR after prior CABG from January 2002 to February 2013 at Emory University...
October 2014: Annals of Thoracic Surgery
Vinod H Thourani, Seyed Amirhossein Razavi, Tom C Nguyen, Patrick D Kilgo, John D Puskas, Robert A Guyton, Omar M Lattouf, Bradley G Leshnower, Edward P Chen, Eric L Sarin, Michael E Halkos
BACKGROUND: Atherosclerotic disease of the ascending aorta during coronary artery bypass graft surgery (CABG) increases the risk for postoperative stroke. The objective of this study was to examine the incidence of postoperative stroke in CABG utilizing the Heartstring (Maquet Cardiovascular, San Jose, CA) proximal anastomotic device. METHODS: Intraoperative epiaortic ultrasonography was used to grade atherosclerosis in CABG patients at Emory University from April 2003 to December 2012...
June 2014: Annals of Thoracic Surgery
Sarah Wetherington, Laura Delong, Seema Kini, Emir Veledar, Michael K Schaufele, Anne M McKenzie-Brown, Suephy C Chen
OBJECTIVE: Utilities are values of health-related quality of life (HRQoL) based on patient preference for a health status. The purpose of this study was to compare indirect measures to a directly elicited utility. DESIGN: Cross-sectional study. SETTING AND PATIENTS: Emory Spine Center and the Emory Center for Chronic Pain at Crawford Long Hospital. Patients at least 18 years of age with chronic pain, defined as pain that persists beyond the normal time of healing, usually beyond 6 months...
May 2014: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
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