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Chen Emory

Jose F Condado, Hanna A Jensen, Aneel Maini, Yi-An Ko, Mohammad H Rajaei, Lillian L Tsai, Chandan Devireddy, Bradley Leshnower, Kreton Mavromatis, Eric L Sarin, James Stewart, Robert A Guyton, Vasilis Babaliaros, Edward P Chen, Michael Halkos, Amy Simone, Patricia Keegan, Peter C Block, Vinod H Thourani
BACKGROUND: Screening for internal carotid artery stenosis (ICAS) with Doppler ultrasound is commonly used before cardiovascular surgery. Nevertheless, the relationship between ICAS and procedure-related stroke in isolated aortic valve replacement is unclear. METHODS: We retrospectively reviewed patients with artery stenosis who underwent ICAS screening before surgical (SAVR) or transcatheter aortic valve replacement (TAVR) between January 2007 and August 2014. Logistic regression models were used to determine the relation between post-procedure stroke and total (sum of left and right ICAS) and maximal unilateral ICAS...
October 4, 2016: Annals of Thoracic Surgery
Richard R Orlandi, Todd T Kingdom, Peter H Hwang, Timothy L Smith, Jeremiah A Alt, Fuad M Baroody, Pete S Batra, Manuel Bernal-Sprekelsen, Neil Bhattacharyya, Rakesh K Chandra, Alexander Chiu, Martin J Citardi, Noam A Cohen, John DelGaudio, Martin Desrosiers, Hun-Jong Dhong, Richard Douglas, Berrylin Ferguson, Wytske J Fokkens, Christos Georgalas, Andrew Goldberg, Jan Gosepath, Daniel L Hamilos, Joseph K Han, Richard Harvey, Peter Hellings, Claire Hopkins, Roger Jankowski, Amin R Javer, Robert Kern, Stilianos Kountakis, Marek L Kowalski, Andrew Lane, Donald C Lanza, Richard Lebowitz, Heung-Man Lee, Sandra Y Lin, Valerie Lund, Amber Luong, Wolf Mann, Bradley F Marple, Kevin C McMains, Ralph Metson, Robert Naclerio, Jayakar V Nayak, Nobuyoshi Otori, James N Palmer, Sanjay R Parikh, Desiderio Passali, Anju Peters, Jay Piccirillo, David M Poetker, Alkis J Psaltis, Hassan H Ramadan, Vijay R Ramakrishnan, Herbert Riechelmann, Hwan-Jung Roh, Luke Rudmik, Raymond Sacks, Rodney J Schlosser, Brent A Senior, Raj Sindwani, James A Stankiewicz, Michael Stewart, Bruce K Tan, Elina Toskala, Richard Voegels, De Yun Wang, Erik K Weitzel, Sarah Wise, Bradford A Woodworth, Peter-John Wormald, Erin D Wright, Bing Zhou, David W Kennedy
BACKGROUND: The body of knowledge regarding rhinosinusitis(RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). METHODS: Evidence-based reviews with recommendations(EBRRs) were developed for scores of topics, using previously reported methodology...
February 2016: International Forum of Allergy & Rhinology
Shih-Chuan Tsai, Yu-Cheng Chang, Kuo-Feng Chiang, Wan-Yu Lin, Jin-Long Huang, Guang-Uei Hung, Chia-Hung Kao, Ji Chen
For patients with coronary artery disease, larger scar burdens are associated with higher risk of ventricular arrhythmia. Left ventricular (LV) dyssynchrony is associated with increased risk of sudden cardiac death in patients with heart failure. The purpose of this study was to assess the values of LV dyssynchrony and myocardial scar assessed by myocardial perfusion SPECT (MPS) in predicting the development of ventricular arrhythmia in ischemic cardiomyopathy. Twenty-two patients (16 males, mean age: 66 ± 13) with irreversible ischemic cardiomyopathy received cardiac resynchronization therapy (CRT) for at least 12 months were enrolled for MPS...
February 2016: Medicine (Baltimore)
Li Chen, Zhaohui S Qin
UNLABELLED: Genome-wide association studies (GWASs) have successfully identified many sequence variants that are significantly associated with common diseases and traits. Tens of thousands of such trait-associated SNPs have already been cataloged, which we believe form a great resource for genomic research. Recent studies have demonstrated that the collection of trait-associated SNPs can be exploited to indicate whether a given genomic interval or intervals are likely to be functionally connected with certain phenotypes or diseases...
April 15, 2016: Bioinformatics
Jay Chauhan, Shen-En Chen, Katherine J Fenstermacher, Aurash Naser-Tavakolian, Tali Reingewertz, Rosene Salmo, Christian Lee, Emori Williams, Mithun Raje, Eric Sundberg, Jeffrey J DeStefano, Ernesto Freire, Steven Fletcher
Small-molecule mimetics of the β-hairpin flap of HIV-1 protease (HIV-1 PR) were designed based on a 1,4-benzodiazepine scaffold as a strategy to interfere with the flap-flap protein-protein interaction, which functions as a gated mechanism to control access to the active site. Michaelis-Menten kinetics suggested our small-molecules are competitive inhibitors, which indicates the mode of inhibition is through binding the active site or sterically blocking access to the active site and preventing flap closure, as designed...
November 1, 2015: Bioorganic & Medicinal Chemistry
Bradley G Leshnower, Vinod H Thourani, Michael E Halkos, Eric L Sarin, William B Keeling, Mark J Lamias, Robert A Guyton, Edward P Chen
BACKGROUND: Despite improved results with surgical therapy for acute type A aortic dissection (ATAAD), there remains a lack of consensus regarding the optimal method of cerebral protection and circulation management during ATAAD. The purpose of this study is to determine whether in the setting of antegrade cerebral perfusion, moderate hypothermic circulatory arrest (MHCA) provides equivalent cerebral and visceral protection as deep hypothermic circulatory arrest (DHCA) for patients undergoing emergent ATAAD repair...
November 2015: Annals of Thoracic Surgery
Po-Nien Hou, Shih-Chuan Tsai, Wan-Yu Lin, Chien-Ming Cheng, Kuo-Feng Chiang, Yu-Cheng Chang, Jin-Long Huang, Guang-Uei Hung, Shih-Ann Chen, Ji Chen
BACKGROUND: Ventricular arrhythmia is the major cause of sudden cardiac death for patients with heart failure, including those receiving implantation of cardiac resynchronization therapy (CRT). The purpose of this study was to assess the value of myocardial perfusion SPECT (MPS) in predicting ventricular arrhythmia for patients with CRT. METHODS AND METHODS: Fifty-one patients (35 males, mean age 64 ± 12 years) who had received CRT for at least 6 months were enrolled for resting gated MPS...
November 2015: Annals of Nuclear Medicine
Walid L Shaib, Ludmila Katherine Martin, Minsing Choi, Zhengjia Chen, Kavya Krishna, Sungjin Kim, Edith Brutcher, Charles Staley, Shishir K Maithel, Philip Philip, Sherif Abdel-Misih, Tanios S Bekaii-Saab, Bassel F El-Rayes
PURPOSE: Appendiceal mucinous neoplasms (AMN) are a rare heterogeneous group of diseases. In the absence of randomized trials, AMN management is controversial. The goal of this study was to evaluate the impact of hyperthermic intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery on survival in AMN patients. PATIENTS AND METHODS: Patient data including demographics, pathology, type of therapy, and outcomes were collected from Emory University, the Ohio State University, and Wayne State University databases...
August 2015: Oncologist
Walid Shaib, Kavya Krishna, Sungjin Kim, Michael Goodman, Jonathan Rock, Zhengjia Chen, Edith Brutcher, Charles Iii Staley, Shishir K Maithel, Samih Abdel-Missih, Bassel F El-Rayes, Tanios Bekaii-Saab
PURPOSE: Appendiceal tumors are a heterogeneous group of diseases that include typical neuroendocrine tumors (TNET), goblet cell carcinoids (GCC), and atypical GCC. Atypical GCC are classified into signet-ring cell cancers (SRCC) and poorly differentiated appendiceal adenocarcinoids. The prognosis and management of these diseases is unclear because there are no prospective studies. The aim of this study is to assess the characteristics and outcome of appendiceal TNET, GCC, and SRCC patients...
April 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Li Chen, Chi Wang, Zhaohui S Qin, Hao Wu
MOTIVATION: ChIP-seq is a powerful technology to measure the protein binding or histone modification strength in the whole genome scale. Although there are a number of methods available for single ChIP-seq data analysis (e.g. 'peak detection'), rigorous statistical method for quantitative comparison of multiple ChIP-seq datasets with the considerations of data from control experiment, signal to noise ratios, biological variations and multiple-factor experimental designs is under-developed...
June 15, 2015: Bioinformatics
Eric R Kallwitz, Martha L Daviglus, Matthew A Allison, Kristen T Emory, Lihui Zhao, Mark H Kuniholm, Jinsong Chen, Natalia Gouskova, Amber Pirzada, Gregory A Talavera, Marston E Youngblood, Scott J Cotler
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) was shown to disproportionally affect Hispanic persons. We examined the prevalence of suspected NAFLD in Hispanic/Latino persons with diverse backgrounds. METHODS: We studied the prevalence of suspected NAFLD among 12,133 persons included in the Hispanic Community Health Study/Study of Latinos. We collected data on levels of aminotransferase, metabolic syndrome (defined by National Cholesterol Education Program-Adult Treatment Panel III guidelines), demographics, and health behaviors...
March 2015: Clinical Gastroenterology and Hepatology
Naif A M Almontashiri, Ragnar O Vilmundarson, Nima Ghasemzadeh, Sonny Dandona, Robert Roberts, Arshed A Quyyumi, Hsiao-Huei Chen, Alexandre F R Stewart
OBJECTIVE: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that promotes degradation of the low density lipoprotein (LDL) receptor. Mutations that block PCSK9 secretion reduce LDL-cholesterol and the incidence of myocardial infarction (MI). However, it remains unclear whether elevated plasma PCSK9 associates with coronary atherosclerosis (CAD) or more directly with rupture of the plaque causing MI. METHODS AND RESULTS: Plasma PCSK9 was measured by ELISA in 645 angiographically defined controls (<30% coronary stenosis) and 3,273 cases of CAD (>50% stenosis in a major coronary artery) from the Ottawa Heart Genomics Study...
2014: PloS One
Tom C Nguyen, Vasilis C Babaliaros, Seyed Amirhossein Razavi, Patrick D Kilgo, Chandan M Devireddy, Brad G Leshnower, Kreton Mavromatis, Robert A Guyton, Mihir Kanitkar, Stam Lerakis, John Merlino, Edward P Chen, Vinod H Thourani
BACKGROUND: An increasing number of patients with prior coronary artery bypass grafting (CABG) now present with severe aortic stenosis. The proposed benefit of surgical (SAVR) vs transcatheter aortic valve replacement (TAVR) is unknown. The objective of this study was to compare short-term and midterm outcomes of patients undergoing isolated SAVR vs TAVR in those with prior CABG. METHODS: A retrospective analysis was performed of 255 patients who underwent isolated SAVR after prior CABG from January 2002 to February 2013 at Emory University...
October 2014: Annals of Thoracic Surgery
Vinod H Thourani, Seyed Amirhossein Razavi, Tom C Nguyen, Patrick D Kilgo, John D Puskas, Robert A Guyton, Omar M Lattouf, Bradley G Leshnower, Edward P Chen, Eric L Sarin, Michael E Halkos
BACKGROUND: Atherosclerotic disease of the ascending aorta during coronary artery bypass graft surgery (CABG) increases the risk for postoperative stroke. The objective of this study was to examine the incidence of postoperative stroke in CABG utilizing the Heartstring (Maquet Cardiovascular, San Jose, CA) proximal anastomotic device. METHODS: Intraoperative epiaortic ultrasonography was used to grade atherosclerosis in CABG patients at Emory University from April 2003 to December 2012...
June 2014: Annals of Thoracic Surgery
Sarah Wetherington, Laura Delong, Seema Kini, Emir Veledar, Michael K Schaufele, Anne M McKenzie-Brown, Suephy C Chen
OBJECTIVE: Utilities are values of health-related quality of life (HRQoL) based on patient preference for a health status. The purpose of this study was to compare indirect measures to a directly elicited utility. DESIGN: Cross-sectional study. SETTING AND PATIENTS: Emory Spine Center and the Emory Center for Chronic Pain at Crawford Long Hospital. Patients at least 18 years of age with chronic pain, defined as pain that persists beyond the normal time of healing, usually beyond 6 months...
May 2014: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Xianhe Lin, Huiqin Xu, Xuefeng Zhao, Ji Chen
OBJECTIVE: Sites of latest mechanical activation (SOLA) have been recognized as optimal left-ventricular (LV) lead positions for cardiac resynchronization therapy (CRT). This study was aimed to investigate SOLA in ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) patients with left bundle branch block (LBBB). METHODS: Sixty-four consecutive LBBB patients (47 DCM, 17 ICM), who met the standard indications for CRT and underwent resting SPECT myocardial perfusion imaging (MPI), were selected...
June 2014: European Journal of Nuclear Medicine and Molecular Imaging
Walid L Shaib, Rahul Sharma, Edith Brutcher, Sungjin Kim, Shishir K Maithel, Zhengjia Chen, David A Kooby, John Kauh, Jerome Landry, Bassel F El-Rayes
BACKGROUND: Ampullary (AMP-A) and duodenal adenocarcinomas (DA) are rare tumors. The literature regarding treatment and outcome is very limited. The objective of this project is to compare the outcomes of AMP-A and DA. METHODS: The records for AMP-A and DA patients between July 1995 and July 2012 at Emory University were reviewed for demographics, pathology, treatment, and survival. Survival rates were estimated by Kaplan-Meier method and compared with log-rank test...
May 2014: Journal of Surgical Oncology
Bradley G Leshnower, Robert A Guyton, Laronica McPherson, Patrick D Kilgo, Edward P Chen
BACKGROUND: Valve-sparing root replacement is controversial in patients with significant aortic insufficiency (AI) because the aortic valve cusps often require repair, which may potentially jeopardize long-term valve function. The purpose of this study was to evaluate valve function and left ventricular reverse remodeling in patients undergoing valve-sparing root replacement in the setting of significant AI. METHODS: A review of the Emory Aortic Surgery database between 2004 and 2012 identified 616 aortic root replacements...
December 2013: Annals of Thoracic Surgery
Amrou Sarraj, Karen Albright, Andrew D Barreto, Amelia K Boehme, Clark W Sitton, Jeanie Choi, Steven L Lutzker, Chung-Huan J Sun, Wafi Bibars, Claude B Nguyen, Osman Mir, Farhaan Vahidy, Tzu-Ching Wu, George A Lopez, Nicole R Gonzales, Randall Edgell, Sheryl Martin-Schild, Hen Hallevi, Peng Roc Chen, Mark Dannenbaum, Jeffrey L Saver, David S Liebeskind, Raul G Nogueira, Rishi Gupta, James C Grotta, Sean I Savitz
BACKGROUND AND PURPOSE: Intra-arterial therapy (IAT) promotes recanalization of large artery occlusions in acute ischemic stroke. Despite high recanalization rates, poor clinical outcomes are common. We attempted to optimize a score that combines clinical and imaging variables to more accurately predict poor outcome after IAT in anterior circulation occlusions. METHODS: Patients with acute ischemic stroke undergoing IAT at University of Texas (UT) Houston for large artery occlusions (middle cerebral artery or internal carotid artery) were reviewed...
December 2013: Stroke; a Journal of Cerebral Circulation
Zhengjia Chen, Zhibo Wang, Haibin Wang, Taofeek K Owonikoko, Jeanne Kowalski, Fadlo R Khuri
Isotonic Design using Normalized Equivalent Toxicity Score (ID-NETS) is a novel Phase I design that integrates the novel toxicity scoring system originally proposed by Chen et al. [1] and the original Isotonic Design proposed by Leung et al. [2]. ID-NETS has substantially improved the accuracy of maximum tolerated dose (MTD) estimation and trial efficiency in the Phase I clinical trial setting by fully utilizing all toxicities experienced by each patient and treating toxicity response as a quasi-continuous variable instead of a binary indicator of dose limiting toxicity (DLT)...
2013: Open Medical Informatics Journal
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