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JOURNAL ARTICLE
Nathaniel L Matteson, Gabriel W Hassler, Ezra Kurzban, Madison A Schwab, Sarah A Perkins, Karthik Gangavarapu, Joshua I Levy, Edyth Parker, David Pride, Abbas Hakim, Peter De Hoff, Willi Cheung, Anelizze Castro-Martinez, Andrea Rivera, Anthony Veder, Ariana Rivera, Cassandra Wauer, Jacqueline Holmes, Jedediah Wilson, Shayla N Ngo, Ashley Plascencia, Elijah S Lawrence, Elizabeth W Smoot, Emily R Eisner, Rebecca Tsai, Marisol Chacón, Nathan A Baer, Phoebe Seaver, Rodolfo A Salido, Stefan Aigner, Toan T Ngo, Tom Barber, Tyler Ostrander, Rebecca Fielding-Miller, Elizabeth H Simmons, Oscar E Zazueta, Idanya Serafin-Higuera, Manuel Sanchez-Alavez, Jose L Moreno-Camacho, Abraham García-Gil, Ashleigh R Murphy Schafer, Eric McDonald, Jeremy Corrigan, John D Malone, Sarah Stous, Seema Shah, Niema Moshiri, Alana Weiss, Catelyn Anderson, Christine M Aceves, Emily G Spencer, Emory C Hufbauer, Justin J Lee, Alison J King, Karthik S Ramesh, Kelly N Nguyen, Kieran Saucedo, Refugio Robles-Sikisaka, Kathleen M Fisch, Steven L Gonias, Amanda Birmingham, Daniel McDonald, Smruthi Karthikeyan, Natasha K Martin, Robert T Schooley, Agustin J Negrete, Horacio J Reyna, Jose R Chavez, Maria L Garcia, Jose M Cornejo-Bravo, David Becker, Magnus Isaksson, Nicole L Washington, William Lee, Richard S Garfein, Marco A Luna-Ruiz Esparza, Jonathan Alcántar-Fernández, Benjamin Henson, Kristen Jepsen, Beatriz Olivares-Flores, Gisela Barrera-Badillo, Irma Lopez-Martínez, José E Ramírez-González, Rita Flores-León, Stephen F Kingsmore, Alison Sanders, Allorah Pradenas, Benjamin White, Gary Matthews, Matt Hale, Ronald W McLawhon, Sharon L Reed, Terri Winbush, Ian H McHardy, Russel A Fielding, Laura Nicholson, Michael M Quigley, Aaron Harding, Art Mendoza, Omid Bakhtar, Sara H Browne, Jocelyn Olivas Flores, Diana G Rincon Rodríguez, Martin Gonzalez Ibarra, Luis C Robles Ibarra, Betsy J Arellano Vera, Jonathan Gonzalez Garcia, Alicia Harvey-Vera, Rob Knight, Louise C Laurent, Gene W Yeo, Joel O Wertheim, Xiang Ji, Michael Worobey, Marc A Suchard, Kristian G Andersen, Abraham Campos-Romero, Shirlee Wohl, Mark Zeller
The maturation of genomic surveillance in the past decade has enabled tracking of the emergence and spread of epidemics at an unprecedented level. During the COVID-19 pandemic, for example, genomic data revealed that local epidemics varied considerably in the frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage importation and persistence, likely due to a combination of COVID-19 restrictions and changing connectivity. Here, we show that local COVID-19 epidemics are driven by regional transmission, including across international boundaries, but can become increasingly connected to distant locations following the relaxation of public health interventions...
December 21, 2023: Cell
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JOURNAL ARTICLE
Andrea M Yeung, Sudha Dirisanala, Amalia Abraham, Jingtong Huang, Grayson M Brennan, María Agustina Urrutia, Jesica D Baran, Kevin T Nguyen, Nicole Y Xu, Trisha Shang, Jennifer Y Zhang, David C Klonoff, Georgia M Davis, Francisco J Pasquel
BACKGROUND: The magnitude of the response of the diabetes professional community to the COVID-19 pandemic is not known. We aimed to examine diabetes technology research trends and resources offered by professional organizations during this period. METHODS: We explored patterns of the response from the professional diabetes community to the pandemic by (1) systematically searching for articles related to diabetes, COVID-19, and diabetes technologies; (2) examining publication trends of research protocols (clinicaltrials...
July 14, 2023: Journal of Diabetes Science and Technology
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JOURNAL ARTICLE
Le Ngoc Ha, Nguyen Thi Thanh Trung, Mai Hong Son, Do Van Chien, Jin Chun Paeng
Objective This study is aimed to assess the prognostic value of diastolic left ventricular mechanical dyssynchrony (LVMD) measured by gated-single photon emission computed tomography (GSPECT) myocardial perfusion imaging (MPI) in post-myocardial infarction (MI). Subjects and Methods The study was conducted on 106 post-MI from January 2015 to January 2019. First, the indices of diastolic LVMD phase standard deviation (PSD) and histogram bandwidth (HBW) of post-MI were measured using the Cardiac Emory Toolbox...
June 2023: World Journal of Nuclear Medicine
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JOURNAL ARTICLE
Sarah Hernandez, Phuong-Vi Nguyen, Taz Azmain, Anne Piantadosi, Jesse J Waggoner
Since the beginning of the SARS-CoV-2 pandemic, supply chain shortages have caused major disruptions in sourcing the materials needed for laboratory-based molecular assays. With increasing demand for molecular testing, these disruptions have limited testing capacity and hindered efforts to mitigate spread of the virus and new variants. Here we evaluate an economical and reliable protocol for the extraction and short-term ambient temperature storage of SARS-CoV-2 RNA. Additional objectives of the study were to evaluate RNA from this protocol for 1) detection of single nucleotide polymorphisms (SNPs) in the spike gene and 2) whole genome sequencing of SARS-CoV-2...
2023: PloS One
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JOURNAL ARTICLE
Jerry Flores, Kristen Emory, Xuan Santos, Angela Mashford-Pringle, Kati Barahona-Lopez, Keston Bozinovic, Jennifer Adams, Coco Chen, Yandy Zuo, Diana Nguyen
This article explores the unique and understudied experiences of Indigenous women living in Toronto, Canada during the first year of the COVID-19 pandemic. The purpose of this study is to better document the impacts of COVID-19 on the mental health and wellbeing of Indigenous women in Toronto, Canada to better understand unmet needs, as well as lay the groundwork for more targeted research and potential interventions based on these needs. Using in-depth semi-structured interviews with thirteen Indigenous women, we shed light on the negative effects this pandemic has had on this population...
2022: Frontiers in sociology
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RANDOMIZED CONTROLLED TRIAL
Emily E Coates, Srilatha Edupuganti, Grace L Chen, Myra Happe, Larisa Strom, Alicia Widge, Maria Burgos Florez, Josephine H Cox, Ingelise Gordon, Sarah Plummer, Abidemi Ola, Galina Yamshchikov, Charla Andrews, Sharon Curate-Ingram, Patricia Morgan, Shashi Nagar, Matthew H Collins, Amy Bray, Thuy Nguyen, Judy Stein, Christopher L Case, Florence Kaltovich, Diane Wycuff, C Jason Liang, Kevin Carlton, Sandra Vazquez, John R Mascola, Julie E Ledgerwood
BACKGROUND: Western (WEEV), eastern (EEEV), and Venezuelan (VEEV) equine encephalitis viruses are mosquito-borne pathogens classified as potential biological warfare agents for which there are currently no approved human vaccines or therapies. We aimed to evaluate the safety, tolerability, and immunogenicity of an investigational trivalent virus-like particle (VLP) vaccine, western, eastern, and Venezuelan equine encephalitis (WEVEE) VLP, composed of WEEV, EEEV, and VEEV VLPs. METHODS: The WEVEE VLP vaccine was evaluated in a phase 1, randomised, open-label, dose-escalation trial at the Hope Clinic of the Emory Vaccine Center at Emory University, Atlanta, GA, USA...
August 2022: Lancet Infectious Diseases
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JOURNAL ARTICLE
Emory Ryan, My-Le Nguyen, Grisel Lopez, Kathleen Mitchell, Margaret Lowery, Suma Singh, Anna Cholewa, W Patricia Bandettini, Charles Moore, Ellen Sidransky
No abstract text is available yet for this article.
January 14, 2021: American Journal of Medicine
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JOURNAL ARTICLE
Doan C Nguyen, Swetha Garimalla, Haopeng Xiao, Shuya Kyu, Igor Albizua, Jacques Galipeau, Kuang-Yueh Chiang, Edmund K Waller, Ronghu Wu, Greg Gibson, James Roberson, Frances E Lund, Troy D Randall, Iñaki Sanz, F Eun-Hyung Lee
The original version of this Article omitted a declaration from the Competing Interests statement, which should have included the following: 'A patent has been applied for by Emory University with F.E.L, I.S. and D.C. N. as named inventors. The patent application number is PCT/US2016/036650'. This has now been corrected in both the PDF and HTML versions of the Article.
January 17, 2019: Nature Communications
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JOURNAL ARTICLE
Robert Townsend Cole, Jonathan Gandhi, Robert A Bray, Howard M Gebel, Michael Yin, Nikolaz Shekiladze, An Young, Aubrey Grant, Ian Mahoney, S Raja Laskar, Divya Gupta, Kunal Bhatt, Wendy Book, Andrew Smith, Duc Nguyen, J David Vega, Alanna A Morris
BACKGROUND: Despite improvements in outcomes after heart transplantation, black recipients have worse survival compared with non-black recipients. The source of such disparate outcomes remains largely unknown. We hypothesize that a propensity to generate de-novo donor-specific antibodies (dnDSA) and subsequent antibody-mediated rejection (AMR) may account for racial differences in sub-optimal outcomes after heart transplant. In this study we aimed to determine the role of dnDSA and AMR in racial disparities in post-transplant outcomes...
April 2018: Journal of Heart and Lung Transplantation
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REVIEW
Emory Hsu, Varun K Phadke, Minh Ly T Nguyen
We describe an HIV-infected patient initiated on combined antiretroviral therapy (cART) who subsequently developed immune restoration disease (IRD) hyperthyroidism-this case represents one of five such patients seen at our center within the past year. Similar to previous reports of hyperthyroidism due to IRD, all of our patients experienced a rapid early recovery in total CD4 count, but developed symptoms of hyperthyroidism on average 3 years (38 months) after beginning cART, which represents a longer time frame than previously reported...
June 2016: AIDS Research and Human Retroviruses
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JOURNAL ARTICLE
William T Hu, Kelly D Watts, Prashant Tailor, Trung P Nguyen, Jennifer C Howell, Raven C Lee, Nicholas T Seyfried, Marla Gearing, Chadwick M Hales, Allan I Levey, James J Lah, Eva K Lee
INTRODUCTION: CSF levels of established Alzheimer's disease (AD) biomarkers remain stable despite disease progression, and non-amyloid non-tau biomarkers have the potential of informing disease stage and progression. We previously identified complement 3 (C3) to be decreased in AD dementia, but this change was not found by others in earlier AD stages. We hypothesized that levels of C3 and associated factor H (FH) can potentially distinguish between mild cognitive impairment (MCI) and dementia stages of AD, but we also found their levels to be influenced by age and disease status...
February 17, 2016: Acta Neuropathologica Communications
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JOURNAL ARTICLE
Vanessa Moll, Elrond Y L Teo, David S Grenda, Cindy D Powell, Michael J Connor, Bryce T Gartland, Mary J Zellinger, H Bruce Bray, Christopher A Paciullo, Craig M Kalin, Jean M Wheeler, Duc Q Nguyen, James M Blum
Extracorporeal membrane oxygenation (ECMO) is an established therapy in the management of patients with refractory cardiogenic shock or acute respiratory failure. In this report, we describe the rapid development and implementation of an organized ECMO program at a facility that previously provided ad hoc support. The program provides care for patients within the Emory Healthcare system and throughout the Southeastern United States. From September 2014 to February 2015, 16 patients were treated with either venovenous or venoarterial ECMO with a survival to decannulation of 53...
May 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
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COMPARATIVE STUDY
Vinod H Thourani, Chun Li, Chandan Devireddy, Hanna A Jensen, Patrick Kilgo, Bradley G Leshnower, Kreton Mavromatis, Eric L Sarin, Tom C Nguyen, Mihir Kanitkar, Robert A Guyton, Peter C Block, Amanda L Maas, Amy Simone, Patricia Keegan, John Merlino, James P Stewart, Stamatios Lerakis, Vasilis Babaliaros
BACKGROUND: Patient characteristics and procedural outcomes from nontransfemoral (non-TF) transcatheter aortic valve replacement (TAVR) in high-risk or inoperable patients with aortic stenosis have been incompletely reported. The purpose of this study was to compare outcomes with non-TF TAVR access techniques including transapical (TA), transaortic (TAo), and transcarotid (TC) TAVR with a balloon-expandable valve. METHODS: A retrospective review was performed of all patients undergoing TA, TAo, and TC TAVR from 2007 to 2013 at Emory University...
March 2015: Annals of Thoracic Surgery
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JOURNAL ARTICLE
Diana I Simeonova, Ashraf M Attalla, Theresa Nguyen, Emily Stagnaro, Bettina T Knight, W Edward Craighead, Zachary N Stowe, D Jeffrey Newport
OBJECTIVE: There are no published studies examining concurrent associations between temperament and behavior during toddlerhood in offspring of parents with bipolar disorder (OBD), a population at high familial risk for psychopathology. Better understanding of early determinants contributing to well-being or mental illness in this high-risk population has the potential to aid in the identification of problem domains to be targeted clinically, and facilitate the development of early intervention and prevention initiatives for an appropriate subgroup of children at the youngest possible age...
December 2014: Journal of Child and Adolescent Psychopharmacology
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JOURNAL ARTICLE
Tom C Nguyen, Vasilis C Babaliaros, Seyed Amirhossein Razavi, Patrick D Kilgo, Chandan M Devireddy, Brad G Leshnower, Kreton Mavromatis, Robert A Guyton, Mihir Kanitkar, Stam Lerakis, John Merlino, Edward P Chen, Vinod H Thourani
BACKGROUND: An increasing number of patients with prior coronary artery bypass grafting (CABG) now present with severe aortic stenosis. The proposed benefit of surgical (SAVR) vs transcatheter aortic valve replacement (TAVR) is unknown. The objective of this study was to compare short-term and midterm outcomes of patients undergoing isolated SAVR vs TAVR in those with prior CABG. METHODS: A retrospective analysis was performed of 255 patients who underwent isolated SAVR after prior CABG from January 2002 to February 2013 at Emory University...
October 2014: Annals of Thoracic Surgery
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JOURNAL ARTICLE
Vinod H Thourani, Seyed Amirhossein Razavi, Tom C Nguyen, Patrick D Kilgo, John D Puskas, Robert A Guyton, Omar M Lattouf, Bradley G Leshnower, Edward P Chen, Eric L Sarin, Michael E Halkos
BACKGROUND: Atherosclerotic disease of the ascending aorta during coronary artery bypass graft surgery (CABG) increases the risk for postoperative stroke. The objective of this study was to examine the incidence of postoperative stroke in CABG utilizing the Heartstring (Maquet Cardiovascular, San Jose, CA) proximal anastomotic device. METHODS: Intraoperative epiaortic ultrasonography was used to grade atherosclerosis in CABG patients at Emory University from April 2003 to December 2012...
June 2014: Annals of Thoracic Surgery
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JOURNAL ARTICLE
Vinod H Thourani, Rebecca L Gunter, Soumya Neravetla, Peter Block, Robert A Guyton, Patrick Kilgo, Stamatios Lerakis, Chandan Devireddy, Bradley Leshnower, Kreton Mavromatis, James Stewart, Amy Simone, Patricia Keegan, Tom C Nguyen, John Merlino, Vasilis Babaliaros
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is an effective treatment in patients with severe aortic stenosis unsuitable for surgical aortic valve replacement (SAVR). This study evaluated the early experience with the posttrial application of TAVR, with specific focus on non-transfemoral (TF) access. METHODS: All patients who underwent posttrial TAVR at Emory University from November 2011 to April 2012 were reviewed. During this time, 44 posttrial TAVRs were performed: TF in 18, transapical in 11, transaortic in 12, and transcarotid in 3...
October 2013: Annals of Thoracic Surgery
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JOURNAL ARTICLE
Amrou Sarraj, Karen Albright, Andrew D Barreto, Amelia K Boehme, Clark W Sitton, Jeanie Choi, Steven L Lutzker, Chung-Huan J Sun, Wafi Bibars, Claude B Nguyen, Osman Mir, Farhaan Vahidy, Tzu-Ching Wu, George A Lopez, Nicole R Gonzales, Randall Edgell, Sheryl Martin-Schild, Hen Hallevi, Peng Roc Chen, Mark Dannenbaum, Jeffrey L Saver, David S Liebeskind, Raul G Nogueira, Rishi Gupta, James C Grotta, Sean I Savitz
BACKGROUND AND PURPOSE: Intra-arterial therapy (IAT) promotes recanalization of large artery occlusions in acute ischemic stroke. Despite high recanalization rates, poor clinical outcomes are common. We attempted to optimize a score that combines clinical and imaging variables to more accurately predict poor outcome after IAT in anterior circulation occlusions. METHODS: Patients with acute ischemic stroke undergoing IAT at University of Texas (UT) Houston for large artery occlusions (middle cerebral artery or internal carotid artery) were reviewed...
December 2013: Stroke; a Journal of Cerebral Circulation
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