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JOURNAL ARTICLE
Jerry R Mendell, Crystal Proud, Craig M Zaidman, Stefanie Mason, Eddie Darton, Shufang Wang, Christoph Wandel, Alexander P Murphy, Eugenio Mercuri, Francesco Muntoni, Craig M McDonald
BACKGROUND: Delandistrogene moxeparvovec is a gene transfer therapy approved in the United States, United Arab Emirates, and Qatar for the treatment of ambulatory patients aged four through five years with a confirmed Duchenne muscular dystrophy (DMD)-causing mutation in the DMD gene. This therapy was developed to address the underlying cause of DMD through targeted skeletal, respiratory, and cardiac muscle expression of delandistrogene moxeparvovec micro-dystrophin, an engineered, functional dystrophin protein...
January 5, 2024: Pediatric Neurology
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JOURNAL ARTICLE
Aleksandra D Chybowska, Danni A Gadd, Yipeng Cheng, Elena Bernabeu, Archie Campbell, Rosie M Walker, Andrew M McIntosh, Nicola Wrobel, Lee Murphy, Paul Welsh, Naveed Sattar, Jackie F Price, Daniel L McCartney, Kathryn L Evans, Riccardo E Marioni
BACKGROUND: Cardiovascular disease (CVD) is among the leading causes of death worldwide. The discovery of new omics biomarkers could help to improve risk stratification algorithms and expand our understanding of molecular pathways contributing to the disease. Here, ASSIGN-a cardiovascular risk prediction tool recommended for use in Scotland-was examined in tandem with epigenetic and proteomic features in risk prediction models in ≥12 657 participants from the Generation Scotland cohort...
January 30, 2024: Circulation. Genomic and Precision Medicine
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JOURNAL ARTICLE
Dhruv Sarma, Mitchell Padkins, Ryan Smith, Courtney E Bennett, Joseph G Murphy, Malcolm R Bell, Abdulla A Damluji, Nandan S Anavekar, Gregory W Barsness, Jacob C Jentzer
Limited data exist regarding outcomes after coronary angiography (CAG) and percutaneous coronary intervention (PCI) in patients aged ≥90 years admitted to the cardiac intensive care unit (CICU) with acute coronary syndrome (ACS). We studied sequential CICU patients ≥90 years admitted with ACS from 2007-2018. Three therapeutic approaches were defined: 1) No CAG; 2) CAG without PCI (CAG/No PCI); and 3) CAG with PCI (CAG/PCI). In-hospital mortality was evaluated using multivariable logistic regression...
January 22, 2024: American Journal of Cardiology
#24
JOURNAL ARTICLE
Emma E Thomas, Susie Cartledge, Barbara Murphy, Bridget Abell, Robyn Gallagher, Carolyn Astley
AIMS: Cardiac rehabilitation (CR) is traditionally delivered in-person; however, the COVID-19 pandemic provided impetus for alternative offerings such as telehealth. We investigated uptake, barriers, and enablers in a national survey during the pandemic in Australia. METHODS AND RESULTS: We surveyed CR programmes between April and June 2021 using professional association networks. The anonymous online questionnaire addressed programme characteristics, COVID-19 impacts, and barriers to and enablers of telehealth use...
January 2024: European heart journal. Digital health
#25
JOURNAL ARTICLE
Mouhammad Yabrodi, Sarah Abdel-Mageed, Kamal Abulebda, Lee D Murphy, Andrew Rodenbarger, Hamza Bhai, Riad Lutfi, Matthew L Friedman
Background: Advancements in palliative surgery of patients with single ventricle physiology have led to an increase in the need for deep sedation protocols for painful procedures. However, positive pressure ventilation during anesthesia can result in unfavorable cardiopulmonary interactions. This patient population may benefit from sedation from these painful procedures. Methods: This study aims to demonstrate the safety and efficacy of deep sedation by pediatric intensivists outside the operating room for children with single ventricle physiology...
January 11, 2024: World Journal for Pediatric & Congenital Heart Surgery
#26
JOURNAL ARTICLE
Muhummad Sohaib Nazir, Joseph Okafor, Theodore Murphy, Maria Sol Andres, Sivatharshini Ramalingham, Stuart D Rosen, Amedeo Chiribiri, Sven Plein, Sanjay Prasad, Raad Mohiaddin, Dudley J Pennell, A John Baksi, Rajdeep Khattar, Alexander R Lyon
Purpose To compare left ventricular ejection fraction (LVEF) measured with echocardiography and cardiac MRI in individuals with cancer and suspected cardiotoxicity and assess the potential effect on downstream clinical decision-making. Materials and Methods In this prospective, single-center observational cohort study, participants underwent same-day two-dimensional (2D) echocardiography and cardiac MRI between 2011 and 2021. Participants with suboptimal image quality were excluded. A subset of 74 participants also underwent three-dimensional (3D) echocardiography...
February 2024: Radiology. Cardiothoracic imaging
#27
JOURNAL ARTICLE
Barbara M Murphy, Michelle C Rogerson, Michael R Le Grande, Stephanie Hesselson, Siiri E Iismaa, Robert M Graham, Alun C Jackson
INTRODUCTION: Recent studies suggest that acute myocardial infarction due to spontaneous coronary artery dissection (SCAD) carries significant psychosocial burden. This survey-based quantitative study builds on our earlier qualitative investigation of the psychosocial impacts of SCAD in Australian SCAD survivors. The study aimed to document the prevalence and predictors of a broad range of psychosocial and lifestyle impacts of SCAD. METHOD: Australian SCAD survivors currently enrolled in the Victor Chang Cardiac Research Institute genetics study were invited to participate in an online survey to assess the psychosocial impacts of SCAD...
2024: PloS One
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JOURNAL ARTICLE
Hugo Mays, Rory Durand, Habitha Sulaiman, Ross Murphy
A Caucasian man in his mid-50s presented to the emergency department with sudden onset right-sided weakness and dysarthria. CT angiogram demonstrated a small volume of left middle cerebral artery territory infarction after which the patient underwent successful thrombolysis. Initial ECG showed diffuse T wave inversion. He was admitted to an acute stroke ward where 72 hours of telemetry demonstrated normal sinus rhythm without arrhythmia. Transthoracic echocardiogram showed a reduced ejection fraction of 47% in the absence of any regional wall motion abnormality...
December 28, 2023: BMJ Case Reports
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JOURNAL ARTICLE
John Graby, Ali Khavandi, Fiona Gillison, Theresa Smith, David Murphy, Oliver Peacock, Hugh McLeod, Amardeep Dastidar, Charalambos Antoniades, Dylan Thompson, Jonathan Carl Luis Rodrigues
INTRODUCTION: Patients diagnosed with coronary artery disease (CAD) are currently treated with medications and lifestyle advice to reduce the likelihood of disease progression and risk of future major adverse cardiovascular events (MACE). Where obstructive disease is diagnosed, revascularisation may be considered to treat refractory symptoms. However, many patients with coexistent cardiovascular risk factors, particularly those with metabolic syndrome (MetS), remain at heightened risk of future MACE despite current management...
December 12, 2023: BMJ Open
#30
JOURNAL ARTICLE
Bernadette Brady, Alexandra Brown, Michelle Barrett, Vikram Maraj, Fiona Lawler, Ross Murphy, Declan Walsh
Cardio-oncology is a dynamic field. Research has suggested that cancer itself can damage the heart, independent of cancer treatment-related cardiac dysfunction (CTRCD). The aim of this study was to establish the nature of cardiovascular abnormalities reported in cancer, excluding CTRCD. Scoping review search included cardiovascular abnormalities in adults with solid tumour malignancies, and excluded CTRCD and thrombotic events. Three databases (CINAHL, Embase, Medline) were searched, supplemented by a handsearch...
November 30, 2023: BMJ Supportive & Palliative Care
#31
JOURNAL ARTICLE
Gopika SenthilKumar, Boran Katunaric, Zachary Zirgibel, Brian Lindemer, Maria J Jaramillo-Torres, Henry Bordas-Murphy, Mary E Schulz, Paul J Pearson, Julie K Freed
BACKGROUND: Elevated plasma ceramides and microvascular dysfunction both independently predict adverse cardiac events. Despite the known detrimental effects of ceramide on the microvasculature, evidence suggests that activation of the shear-sensitive, ceramide-forming enzyme NSmase (neutral sphingomyelinase) elicits formation of vasoprotective nitric oxide (NO). Here, we explore a novel hypothesis that acute ceramide formation through NSmase is necessary for maintaining NO signaling within the human microvascular endothelium...
January 5, 2024: Circulation Research
#32
JOURNAL ARTICLE
Arnaldo Dimagli, Mario Gaudino, Lamia Harik, Shubhra Sinha, Daniel Fudulu, Jeremy Chan, Roberto Perezgrovas Olaria, Giovanni Soletti, Talal Alzghari, Gianmarco Cancelli, Kevin R An, Umberto Benedetto, Gavin Murphy, Gianni Angelini
BACKGROUND: There is limited report of outcomes in women undergoing isolated coronary artery bypass grafting (CABG) with left internal thoracic artery and different second conduits (saphenous vein grafts [SVGs], radial artery [RA], and right internal thoracic artery [RITA]). METHODS: The National Adult Cardiac Surgery database was queried for women undergoing isolated CABG with left internal thoracic artery graft in the UK from 1996 to 2019. Propensity score-based pairwise comparisons were performed between graft types...
November 15, 2023: Annals of Thoracic Surgery
#33
JOURNAL ARTICLE
Zer Vue, Edgar Garza-Lopez, Kit Neikirk, Prasanna Katti, Larry Vang, Heather Beasley, Jianqiang Shao, Andrea G Marshall, Amber Crabtree, Alexandria C Murphy, Brenita C Jenkins, Praveena Prasad, Chantell Evans, Brittany Taylor, Margaret Mungai, Mason Killion, Dominique Stephens, Trace A Christensen, Jacob Lam, Benjamin Rodriguez, Mark A Phillips, Nastaran Daneshgar, Ho-Jin Koh, Alice Koh, Jamaine Davis, Nina Devine, Saleem Muhammod, Estevão Scudese, Kenneth Ryan Arnold, Valeria Vanessa Chavarin, Ryan Daniel Robinson, Moumita Chakraborty, Jennifer A Gaddy, Mariya T Sweetwyne, Genesis Wilson, Elma Zaganjor, James Kezos, Cristiana Dondi, Anilkumar K Reddy, Brian Glancy, Annet Kirabo, Anita M Quintana, Dao-Fu Dai, Karen Ocorr, Sandra A Murray, Steven M Damo, Vernat Exil, Blake Riggs, Bret C Mobley, Jose A Gomez, Melanie R McReynolds, Antentor Hinton
During aging, muscle gradually undergoes sarcopenia, the loss of function associated with loss of mass, strength, endurance, and oxidative capacity. However, the 3D structural alterations of mitochondria associated with aging in skeletal muscle and cardiac tissues are not well described. Although mitochondrial aging is associated with decreased mitochondrial capacity, the genes responsible for the morphological changes in mitochondria during aging are poorly characterized. We measured changes in mitochondrial morphology in aged murine gastrocnemius, soleus, and cardiac tissues using serial block-face scanning electron microscopy and 3D reconstructions...
November 13, 2023: Aging Cell
#34
JOURNAL ARTICLE
Barbara M Murphy, Rosemary O Higgins, Alun C Jackson
BACKGROUND: Acute cardiac events confer an increased risk of mental health problems, which compromise physical recovery and increase the risk of recurrence and premature mortality. OBJECTIVE: This paper provides an overview of the nature, prevalence, predictors and impacts of post-cardiac event mental health problems, and outlines the benefits of mental health screening, effective treatments for mental health problems and the role of general practitioners (GPs) in the identification and management of mental health problems in cardiac patients...
November 2023: Australian Journal of General Practice
#35
REVIEW
Riccardo Giuseppe Abbasciano, Sara Tomassini, Marius A Roman, Angelica Rizzello, Suraj Pathak, Joussi Ramzi, Carla Lucarelli, Georgia Layton, Ayesha Butt, Florence Lai, Tracy Kumar, Marcin J Wozniak, Gavin J Murphy
BACKGROUND: Organ injury is a common and severe complication of cardiac surgery that contributes to the majority of deaths. There are no effective treatment or prevention strategies. It has been suggested that innate immune system activation may have a causal role in organ injury. A wide range of organ protection interventions targeting the innate immune response have been evaluated in randomised controlled trials (RCTs) in adult cardiac surgery patients, with inconsistent results in terms of effectiveness...
October 24, 2023: Cochrane Database of Systematic Reviews
#36
JOURNAL ARTICLE
Jeffrey L Carson, Simon J Stanworth, Gordon Guyatt, Stacey Valentine, Jane Dennis, Sara Bakhtary, Claudia S Cohn, Allan Dubon, Brenda J Grossman, Gaurav K Gupta, Aaron S Hess, Jessica L Jacobson, Lewis J Kaplan, Yulia Lin, Ryan A Metcalf, Colin H Murphy, Katerina Pavenski, Micah T Prochaska, Jay S Raval, Eric Salazar, Nabiha H Saifee, Aaron A R Tobian, Cynthia So-Osman, Jonathan Waters, Erica M Wood, Nicole D Zantek, Monica B Pagano
IMPORTANCE: Red blood cell transfusion is a common medical intervention with benefits and harms. OBJECTIVE: To provide recommendations for use of red blood cell transfusion in adults and children. EVIDENCE REVIEW: Standards for trustworthy guidelines were followed, including using Grading of Recommendations Assessment, Development and Evaluation methods, managing conflicts of interest, and making values and preferences explicit. Evidence from systematic reviews of randomized controlled trials was reviewed...
November 21, 2023: JAMA
#37
JOURNAL ARTICLE
Alaa Mabrouk Salem Omar, Sean Murphy, G Michael Felker, Ileana Piña, Javed Butler, Yuxi Liu, Reza Mohebi, Kirtipal Bhatia, Jonathan H Ward, Kristin M Williamson, Scott D Solomon, James L Januzzi, Johanna Contreras
OBJECTIVES: To assess tissue Doppler-derived mitral annular isovolumic contraction velocity (ICV) after starting sacubitril/valsartan (sac/val) for the treatment of heart failure with reduced ejection fraction (HFrEF; left ventricular [LV] EF <40%). BACKGROUND: ICV may inform load-independent systolic function; combining ICV and LVEF may improve assessment of LV contractility. METHODS: Among 651 HFrEF participants treated with sac/val, echocardiograms were performed at baseline, 6, and 12 months...
October 7, 2023: Journal of Cardiac Failure
#38
JOURNAL ARTICLE
Jennifer Z Liu, Catherine R Counts, Christopher J Drucker, Jamie M Emert, David L Murphy, Leilani Schwarcz, Peter J Kudenchuk, Michael R Sayre, Thomas D Rea
IMPORTANCE: Little is known about how COVID-19 affects the incidence or outcomes of out-of-hospital cardiac arrest (OHCA), and it is possible that more generalized factors beyond SARS-CoV-2 infection are primarily responsible for changes in OHCA incidence and outcome. OBJECTIVE: To assess whether COVID-19 is associated with OHCA incidence and outcomes. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study was conducted in Seattle and King County, Washington...
October 2, 2023: JAMA Network Open
#39
JOURNAL ARTICLE
Yuta Kobayashi, Yu-Chung Peng, Evan Yu, Brian Bush, Youn-Hoa Jung, Zachary Murphy, Lee Goeddel, Glenn Whitman, Archana Venkataraman, Charles H Brown
BACKGROUND: Although conventional prediction models for surgical patients often ignore intraoperative time-series data, deep learning approaches are well-suited to incorporate time-varying and non-linear data with complex interactions. Blood lactate concentration is one important clinical marker that can reflect the adequacy of systemic perfusion during cardiac surgery. During cardiac surgery and cardiopulmonary bypass, minute-level data is available on key parameters that affect perfusion...
2023: Frontiers in Medicine
#40
JOURNAL ARTICLE
C O Abana, P P Carriere, P Damen, P S N van Rossum, P Lopez Bravo, X Wei, J M Pollard, P L Nitsch, M Blum Murphy, W Hofstetter, Z Liao, S H Lin
PURPOSE/OBJECTIVE(S): Proton-beam therapy (PT) is increasingly utilized over three dimensional-conformal radiation therapy (3D-CRT) and intensity modulated radiation therapy (IMRT) photon irradiation for the treatment of various malignancies due to better toxicity reduction. We investigated the long-term outcomes and toxicity in esophageal cancer (EC) patients treated with PT as part of their neoadjuvant concurrent chemoradiation followed by surgery (nCRT) or definitive concurrent chemoradiation (dCRT) treatment regimen...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
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