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https://www.readbyqxmd.com/read/27852953/effectiveness-of-an-exercise-programme-on-physical-function-in-patients-discharged-from-hospital-following-critical-illness-a-randomised-controlled-trial-the-revive-trial
#1
Kathryn McDowell, Brenda O'Neill, Bronagh Blackwood, Chris Clarke, Evie Gardner, Paul Johnston, Michaeline Kelly, John McCaffrey, Brian Mullan, Sally Murphy, T John Trinder, Gavin Lavery, Daniel F McAuley, Judy M Bradley
OBJECTIVE: To investigate the effectiveness of a 6-week exercise programme in patients discharged home following critical illness compared with standard care. DESIGN: Multicentre prospective phase II randomised controlled trial, with blinded outcome assessment after hospital discharge, following the 6-week intervention and at 6 months. PARTICIPANTS: 60 patients (30 per group) aged ≥18 years, mechanically ventilated >96 hours, and not in other rehabilitation, that is, cardiac or pulmonary rehabilitation programmes...
November 15, 2016: Thorax
https://www.readbyqxmd.com/read/27850154/514-contemporary-epidemiology-of-catheter-related-thrombosis-in-the-pediatric-cardiac-icu
#2
Lee Murphy, Christopher Mastropietro
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27816171/reliable-exclusion-of-prognostically-significant-coronary-disease-in-left-ventricular-dysfunction-by-cardiac-mri
#3
A C M Thompson, J G Crilley, D W Wilson, A P S Hungin, A Fuat, J J M Murphy
AIM: To assess the ability of cardiac magnetic resonance (CMR) to exclude prognostically significant coronary artery disease (CAD) in patients with left ventricular systolic dysfunction (LVSD). MATERIALS AND METHODS: A cohort of patients who underwent both X-ray angiography and CMR since 2006 was reviewed retrospectively. Records of those with European criteria for LVSD (left ventricular ejection fraction [LVEF] <50% or LV end-diastolic volume index [LVEDVI] ≥97 ml/m(2)) on CMR or transthoracic echo were analysed...
November 2, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27779776/a-phase-i-study-to-determine-the-pharmacokinetic-profile-safety-and-tolerability-of-sildenafil-revatio-%C3%A2-in-cardiac-surgery-the-revaki-1-study
#4
Arne Ring, Tom Morris, Marcin Wozniak, Nikol Sullo, William Dott, Veerle Verheyden, Tracy Kumar, Nigel Brunskill, Rakesh Vaja, Gavin J Murphy
AIMS: Acute kidney injury (AKI) is a common and severe complication of cardiac surgery. There is no effective prevention or treatment. Sildenafil citrate (Revatio(®) , Pfizer Inc.), a phosphodiesterase type 5 inhibitor, prevents post cardiac surgery AKI in pre-clinical studies, however its use is contraindicated in patients with symptomatic cardiovascular disease. The aim of this study is to assess the safety and pharmacokinetics of intravenous sildenafil in cardiac surgery patients...
October 25, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27761893/cardiac-involvement-in-female-carriers-of-duchenne-or-becker-muscular-dystrophy
#5
Thomas McCaffrey, Michela Guglieri, Alexander P Murphy, Katherine Md Bushby, Anna Johnson, John P Bourke
Introduction The significance of abnormal cardiac measures in asymptomatic females who harbor dystrophin gene mutations is controversial. Methods Echo-measures of ventricular function were compared with published norms in a cross-sectional study of 130 (age 39 ± 15.7 years) 'carriers' of Duchenne or Becker muscular dystrophy (DBMD). Correlations between cardiomyopathy (CM) and mutation, CK levels, age, and muscle symptoms were investigated. Results Depending on definition, CM prevalence was 3-33%. Ejection fraction (Simpson) was < 55% in 9 (13%) and < 40% in 2 (2...
October 19, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27750047/bgp-15-improves-aspects-of-the-dystrophic-pathology-in-mdx-and-dko-mice-with-differing-efficacies-in-heart-and-skeletal-muscle
#6
Tahnee L Kennedy, Kristy Swiderski, Kate T Murphy, Stefan M Gehrig, Claire L Curl, Chanchal Chandramouli, Mark A Febbraio, Lea M D Delbridge, René Koopman, Gordon S Lynch
Duchenne muscular dystrophy is a severe and progressive striated muscle wasting disorder that leads to premature death from respiratory and/or cardiac failure. We have previously shown that treatment of young dystrophic mdx and dystrophin/utrophin null (dko) mice with BGP-15, a coinducer of heat shock protein 72, ameliorated the dystrophic pathology. We therefore tested the hypothesis that later-stage BGP-15 treatment would similarly benefit older mdx and dko mice when the dystrophic pathology was already well established...
October 14, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27738067/medium-term-outcomes-of-idiopathic-ventricular-fibrillation-survivors-and-family-screening-a-multicentre-experience
#7
Shohreh Honarbakhsh, Neil Srinivasan, Claire Kirkby, Eileen Firman, Liam Tobin, Malcolm Finlay, Ross J Hunter, Cliona Murphy, Martin D Lowe, Richard J Schilling, Pier D Lambiase
AIMS: Early repolarization (ER) has been linked to poorer outcomes in idiopathic ventricular fibrillation (IVF). The role of family screening in IVF is not clear. Our aim was to review predictors for poorer outcomes and evaluate the role of family screening in IVF. METHODS AND RESULTS: This was a retrospective multicentre cohort study including all patients diagnosed with IVF. Data were collected on baseline characteristics, ECG findings, and recurrence of ventricular arrhythmia (VA) during follow-up...
October 12, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27732122/clinical-evaluation-of-quantec-guidelines-to-predict-the-risk-of-cardiac-mortality-in-breast-cancer-patients
#8
Vitali Moiseenko, John Einck, James Murphy, Jakob Ödén, Judith Bjöhle, Julien Uzan, Giovanna Gagliardi
No abstract text is available yet for this article.
October 12, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27724957/implementing-international-sexual-counselling-guidelines-in-hospital-cardiac-rehabilitation-development-of-the-charms-intervention-using-the-behaviour-change-wheel
#9
J Mc Sharry, P J Murphy, M Byrne
BACKGROUND: Decreased sexual activity and sexual problems are common among people with cardiovascular disease, negatively impacting relationship satisfaction and quality of life. International guidelines recommend routine delivery of sexual counselling to cardiac patients. The Cardiac Health and Relationship Management and Sexuality (CHARMS) baseline study in Ireland found, similar to international findings, limited implementation of sexual counselling guidelines in practice. The aim of the current study was to develop the CHARMS multi-level intervention to increase delivery of sexual counselling by healthcare professionals...
October 10, 2016: Implementation Science: IS
https://www.readbyqxmd.com/read/27718144/cardiomyopathy-as-presenting-sign-of-glycogenin-1-deficiency-report-of-three-cases-and-review-of-the-literature
#10
Carola Hedberg-Oldfors, Emma Glamuzina, Peter Ruygrok, Lisa J Anderson, Perry Elliott, Oliver Watkinson, Chris Occleshaw, Malcolm Abernathy, Clinton Turner, Nicola Kingston, Elaine Murphy, Anders Oldfors
We describe a new type of cardiomyopathy caused by a mutation in the glycogenin-1 gene (GYG1). Three unrelated male patients aged 34 to 52 years with cardiomyopathy and abnormal glycogen storage on endomyocardial biopsy were homozygous for the missense mutation p.Asp102His in GYG1. The mutated glycogenin-1 protein was expressed in cardiac tissue but had lost its ability to autoglucosylate as demonstrated by an in vitro assay and western blot analysis. It was therefore unable to form the primer for normal glycogen synthesis...
October 7, 2016: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/27714705/predictive-factors-of-bleeding-events-in-adults-undergoing-extracorporeal-membrane-oxygenation
#11
Cécile Aubron, Joris DePuydt, François Belon, Michael Bailey, Matthieu Schmidt, Jayne Sheldrake, Deirdre Murphy, Carlos Scheinkestel, D Jamie Cooper, Gilles Capellier, Vincent Pellegrino, David Pilcher, Zoe McQuilten
BACKGROUND: Bleeding is the most frequent complication associated with extracorporeal membrane oxygenation (ECMO) support in critically ill patients. Nonetheless, risk factors for bleeding have been poorly described especially those associated with coagulation anomalies and anticoagulant therapy during ECMO support. The aim of this study is to describe bleeding complications in critically ill patients undergoing ECMO and to identify risk factors for bleeding events. METHODS: We retrospectively analysed ICU charts of adults who received either veno-venous (VV) or veno-arterial (VA) ECMO support in two participating ICUs between 2010 and 2013...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27706467/cardiovascular-biomarker-score-and-clinical-outcomes-in-patients-with-atrial-fibrillation-a-subanalysis-of-the-engage-af-timi-48-randomized-clinical-trial
#12
Christian T Ruff, Robert P Giugliano, Eugene Braunwald, Sabina A Murphy, Karen Brown, Petr Jarolim, Michele Mercuri, Elliott M Antman, David A Morrow
Importance: Treatment decisions in atrial fibrillation (AF) are based on clinical assessment of risk. The CHA2DS2-VASc (cardiac failure or dysfunction, hypertension, age 65-74 [1 point] or ≥75 years [2 points], diabetes mellitus, and stroke, transient ischemic attack or thromboembolism [2 points]-vascular disease, and sex category [female]) risk score is pragmatic and widely used but has only moderate discrimination. Objective: To develop and test a cardiovascular biomarker score for indication of risk in patients with AF...
October 5, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27703175/paracrine-effects-of-adipose-derived-stem-cells-on-matrix-stiffness-induced-cardiac-myofibroblast-differentiation-via-angiotensin-ii-type-1-receptor-and-smad7
#13
Kar Wey Yong, Yuhui Li, Fusheng Liu, Bin Gao, Tian Jian Lu, Wan Abu Bakar Wan Abas, Wan Kamarul Zaman Wan Safwani, Belinda Pingguan-Murphy, Yufei Ma, Feng Xu, Guoyou Huang
Human mesenchymal stem cells (hMSCs) hold great promise in cardiac fibrosis therapy, due to their potential ability of inhibiting cardiac myofibroblast differentiation (a hallmark of cardiac fibrosis). However, the mechanism involved in their effects remains elusive. To explore this, it is necessary to develop an in vitro cardiac fibrosis model that incorporates pore size and native tissue-mimicking matrix stiffness, which may regulate cardiac myofibroblast differentiation. In the present study, collagen coated polyacrylamide hydrogel substrates were fabricated, in which the pore size was adjusted without altering the matrix stiffness...
October 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27675651/cardiac-toxicity-with-radiation-therapy-in-esophageal-cancer
#14
N Panjwani, K E Fero, J D Murphy
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27637331/strategic-positioning-and-biased-activity-of-the-mitochondrial-calcium-uniporter-in-cardiac-muscle
#15
Sergio De La Fuente, Celia Fernandez-Sanz, Caitlin Vail, Elorm J Agra, Kira Holmstrom, Junhui Sun, Jyotsna Mishra, Dewight Williams, Toren Finkel, Elizabeth Murphy, Suresh K Joseph, Shey-Shing Sheu, György Csordás
Control of myocardial energetics by Ca(2+) signal propagation to the mitochondrial matrix includes local Ca(2+) delivery from sarcoplasmic reticulum (SR) ryanodine receptors (RyR2) to the inner mitochondrial membrane (IMM) Ca(2+) uniporter (mtCU). mtCU activity in cardiac mitochondria is relatively low, whereas the IMM surface is large, due to extensive cristae folding. Hence, stochastically distributed mtCU may not suffice to support local Ca(2+) transfer. We hypothesized that mtCU concentrated at mitochondria-SR associations would promote the effective Ca(2+) transfer...
October 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27614674/cardiac-rehabilitation-in-the-acute-care-setting-integrative-review
#16
Chezhan Hall, Maria Murphy, Andrew Scanlon
BACKGROUND: Phase one cardiac rehabilitation (CR) is an essential component of care for patients with coronary heart disease. With optimal program delivery, health outcomes can be improved. OBJECTIVES: To conduct an integrative review that explores Phase one CR for patients hospitalised with coronary heart disease. DESIGN: Integrative literature review (2003-2014) Data sources: The literature search included Medline, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Experta Medica Database (EMBASE), Psycinfo, Clinical Practice Guidelines Portal, Cochrane Library, Clinical Evidence (BMJ) and Google Scholar...
September 7, 2016: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/27587565/a-comparison-of-medical-records-and-patient-questionnaires-as-sources-for-the-estimation-of-costs-within-research-studies-and-the-implications-for-economic-evaluation
#17
Paddy Gillespie, Eamon O'Shea, Susan M Smith, Margaret E Cupples, Andrew W Murphy
BACKGROUND: Data on health care utilization may be collected using a variety of mechanisms within research studies, each of which may have implications for cost and cost effectiveness. OBJECTIVE: The aim of this observational study is to compare data collected from medical records searches and self-report questionnaires for the cost analysis of a cardiac secondary prevention intervention. METHODS: Secondary data analysis of the Secondary Prevention of Heart Disease in General Practice (SPHERE) randomized controlled trial (RCT)...
September 1, 2016: Family Practice
https://www.readbyqxmd.com/read/27561177/comparison-of-endoscopic-robotic-versus-sternotomy-approach-for-the-resection-of-left-atrial-tumors
#18
Emmanuel Moss, Michael E Halkos, Jeffrey S Miller, Douglas A Murphy
OBJECTIVE: Primary cardiac tumors most commonly occur in the left atrium. The aim of this study was to compare outcomes among patients undergoing isolated left atrial tumor resection via sternotomy or robotic approach. METHODS: From 2003 to 2013, 69 patients underwent isolated left atrial tumor resection at 3 affiliated hospitals with either a sternotomy (n = 39) or robotic approach (n = 30). A retrospective review of prospectively collected data was performed, and outcomes were compared between the sternotomy and robotic groups...
July 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/27527344/a-multicentre-randomised-controlled-trial-of-transfusion-indication-threshold-reduction-on-transfusion-rates-morbidity-and-health-care-resource-use-following-cardiac-surgery-titre2
#19
Barnaby C Reeves, Katie Pike, Chris A Rogers, Rachel Cm Brierley, Elizabeth A Stokes, Sarah Wordsworth, Rachel L Nash, Alice Miles, Andrew D Mumford, Alan Cohen, Gianni D Angelini, Gavin J Murphy
BACKGROUND: Uncertainty about optimal red blood cell transfusion thresholds in cardiac surgery is reflected in widely varying transfusion rates between surgeons and cardiac centres. OBJECTIVE: To test the hypothesis that a restrictive compared with a liberal threshold for red blood cell transfusion after cardiac surgery reduces post-operative morbidity and health-care costs. DESIGN: Multicentre, parallel randomised controlled trial and within-trial cost-utility analysis from a UK NHS and Personal Social Services perspective...
August 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27525256/molecular-and-integrative-physiological-effects-of-isoflurane-anesthesia-the-paradigm-of-cardiovascular-studies-in-rodents-using-magnetic-resonance-imaging
#20
REVIEW
Christakis Constantinides, Kathy Murphy
To-this-date, the exact molecular, cellular, and integrative physiological mechanisms of anesthesia remain largely unknown. Published evidence indicates that anesthetic effects are multifocal and occur in a time-dependent and coordinated manner, mediated via central, local, and peripheral pathways. Their effects can be modulated by a range of variables, and their elicited end-effect on the integrative physiological response is highly variable. This review summarizes the major cellular and molecular sites of anesthetic action with a focus on the paradigm of isoflurane (ISO) - the most commonly used anesthetic nowadays - and its use in prolonged in vivo rodent studies using imaging modalities, such as magnetic resonance imaging (MRI)...
2016: Frontiers in Cardiovascular Medicine
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