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https://www.readbyqxmd.com/read/28905517/the-prognostic-significance-of-tricuspid-valve-regurgitation-in-pulmonary-arterial-hypertension
#1
Libo Chen, Carolyn M Larsen, Rachel J Le, Heidi M Connolly, Sorin V Pislaru, Joseph G Murphy, Michael D McGoon, Robert P Frantz, Garvan C Kane
INTRODUCTION: Tricuspid valve regurgitation (TR) is a frequent finding in patients with pulmonary arterial hypertension (PAH). However, its prognostic significance and relation to PAH, while suspected, are poorly understood. We assessed 727 consecutive patients with newly diagnosed PAH who underwent transthoracic echocardiographic evaluation of tricuspid valve function. OBJECTIVES: The study objective was to determine the association of TR presence and severity with patient characteristics, pulmonary artery hemodynamics, and outcome...
September 14, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28899987/heart-failure-related-hyperphosphorylation-in-the-cardiac-troponin-i-c-terminus-has-divergent-effects-on-cardiac-function-in-vivo
#2
Yuejin Li, Guangshuo Zhu, Nazareno Paolocci, Pingbo Zhang, Cyrus Takahashi, Nazli Okumus, Amir Heravi, Gizem Keceli, Genaro Ramirez-Correa, David A Kass, Anne M Murphy
BACKGROUND: In human heart failure, Ser199 (equivalent to Ser200 in mouse) of cTnI (cardiac troponin I) is significantly hyperphosphorylated, and in vitro studies suggest that it enhances myofilament calcium sensitivity and alters calpain-mediated cTnI proteolysis. However, how its hyperphosphorylation affects cardiac function in vivo remains unknown. METHODS AND RESULTS: To address the question, 2 transgenic mouse models were generated: a phospho-mimetic cTnIS200D and a phospho-silenced cTnIS200A, each driven by the cardiomyocyte-specific α-myosin heavy chain promoter...
September 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28882917/effects-of-cerebral-near-infrared-spectroscopy-on-the-outcome-of-patients-undergoing-cardiac-surgery-a-systematic-review-of-randomised-trials
#3
Giuseppe Filiberto Serraino, Gavin J Murphy
OBJECTIVES: Goal-directed optimisation of cerebral oxygenation using near-infrared spectroscopy (NIRS) during cardiopulmonary bypass is widely used. We tested the hypotheses that the use of NIRS cerebral oximetry results in reductions in cerebral injury (neurocognitive function, serum biomarkers), injury to other organs including the heart and brain, transfusion rates, mortality and resource use. DESIGN: Systematic review and meta-analysis. SETTING: Tertiary cardiac surgery centres in North America, Europe and Asia...
September 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28863430/obesity-protects-during-cardiac-surgery-professor-gavin-murphy-speaks-to-mark-nicholls-about-a-study-that-could-turn-conventional-thinking-of-a-patient-s-weight-cardiac-health-and-surgery-on-its-head
#4
https://www.readbyqxmd.com/read/28862954/a-systems-biology-approach-to-investigating-sex-differences-in-cardiac-hypertrophy
#5
Josephine Harrington, Natasha Fillmore, Shouguo Gao, Yanqin Yang, Xue Zhang, Poching Liu, Andrea Stoehr, Ye Chen, Danielle Springer, Jun Zhu, Xujing Wang, Elizabeth Murphy
BACKGROUND: Heart failure preceded by hypertrophy is a leading cause of death, and sex differences in hypertrophy are well known, although the basis for these sex differences is poorly understood. METHODS AND RESULTS: This study used a systems biology approach to investigate mechanisms underlying sex differences in cardiac hypertrophy. Male and female mice were treated for 2 and 3 weeks with angiotensin II to induce hypertrophy. Sex differences in cardiac hypertrophy were apparent after 3 weeks of treatment...
August 19, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28846437/oxygen-administration-improves-survival-but-worsens-cardiopulmonary-functions-in-chlorine-exposed-rats
#6
Obiefuna C Okponyia, Matthew D McGraw, Marilyn M Dysart, Rhonda B Garlick, Jacqueline S Rioux, Angela L Murphy, Gates B Roe, Carl W White, Livia A Veress
RATIONALE: Chlorine is a highly reactive gas that can cause significant injury when inhaled. Unfortunately, its use as a chemical weapon has increased in recent years. Massive chlorine inhalation can cause death within 4h of exposure. Survivors usually require hospitalization after massive exposure. No countermeasures exist for massive chlorine exposure, and supportive care measures lack controlled trials. METHODS: Adult rats were exposed to chlorine gas (LD58-67) in a whole-body exposure chamber, and given oxygen (0...
August 28, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28842929/the-effect-of-rurality-on-out-of-hospital-cardiac-arrest-resuscitation-incidence-an-exploratory-study-of-a-national-registry-utilizing-a-categorical-approach
#7
Siobhán Masterson, Conor Teljeur, John Cullinan, Andrew W Murphy, Conor Deasy, Akke Vellinga
PURPOSE: Variation in incidence is a universal feature of out-of-hospital cardiac arrest (OHCA). One potential source of variation is the rurality of the location where the OHCA incident occurs. While previous work has used a simple binary approach to define rurality, the purpose of this study was to use a categorical approach to quantify the impact of urban-rural classification on OHCA incidence in the Republic of Ireland. METHODS: The observed versus expected ratio of OHCA incidence where resuscitation was attempted for the period January 1, 2012, to December 31, 2014, was calculated for each of the 3,408 electoral divisions (ED)...
August 26, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/28826760/evidence-based-red-blood-cell-transfusion-practices-in-cardiac-surgery
#8
REVIEW
Nishith N Patel, Gavin J Murphy
Cardiac surgical patients are among the highest consumers of allogeneic red blood cells (RBCs) due to the prevalence of anemia and bleeding. Up until recently, there was a paucity of high-quality evidence informing transfusion decisions in this patient group which led to wide variability in transfusion decision making. The article reviews and critically analyzes the available evidence for RBC transfusion in cardiac surgery, focusing on trials of transfusion triggers and age of blood, and provides suggestions for future research...
June 21, 2017: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28805027/acute-and-midterm-results-following-perventricular-device-closure-of-muscular-ventricular-septal-defects-a-multicenter-pices-investigation
#9
Robert G Gray, Shaji C Menon, Joyce T Johnson, Aimee K Armstrong, Michael A Bingler, John P Breinholt, Damien Kenny, John Lozier, Joshua J Murphy, Shyam K Sathanandam, Nathaniel W Taggart, Sara M Trucco, Bryan H Goldstein, Brent M Gordon
OBJECTIVES: To describe acute and mid-term results of hybrid perventricular device closure of muscular ventricular septal defects (mVSDs). BACKGROUND: Perventricular device closure of mVSDs can mitigate technical limitations of percutaneous closure and need for cardiopulmonary bypass or ventriculotomy with a surgical approach. METHODS: This is a multicenter retrospective cohort study of patients undergoing hybrid perventricular mVSD device closure from 1/2004 to 1/2014...
August 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28774709/treatment-with-antioxidants-ameliorates-oxidative-damage-in-a-mouse-model-of-propionic-acidemia
#10
Ana Rivera-Barahona, Esmeralda Alonso-Barroso, Belén Pérez, Michael P Murphy, Eva Richard, Lourdes R Desviat
Oxidative stress contributes to the pathogenesis of propionic acidemia (PA), a life threatening disease caused by the deficiency of propionyl CoA-carboxylase, in the catabolic pathway of branched-chain amino acids, odd-number chain fatty acids and cholesterol. Patients develop multisystemic complications including seizures, extrapyramidal symptoms, basal ganglia deterioration, pancreatitis and cardiomyopathy. The accumulation of toxic metabolites results in mitochondrial dysfunction, increased reactive oxygen species and oxidative damage, all of which have been documented in patients' samples and in a hypomorphic mouse model...
July 25, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28761405/eosinophilia-and-ulcerative-colitis-associated-with-eosinophilic-myocarditis
#11
Katie Murphy, Oral Waldo, Graham M Lohrmann, Henry D Tazelaar, Clinton E Jokerst, Farouk Mookadam
Reactive eosinophilia is associated with inflammatory bowel disease, but its association with eosinophilic myocarditis is rare. We report a case of a 42-year-old man who presented with hypovolemic shock secondary to diarrhea and recently diagnosed nonischemic cardiomyopathy (left ventricular ejection fraction, 0.29). Laboratory evaluation revealed marked peripheral eosinophilia. Cardiac magnetic resonance imaging showed evidence of subacute-to-chronic myocarditis, and endomyocardial biopsy results were consistent with eosinophilic myocarditis...
June 2017: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/28756627/pathogen-reduced-platelets-for-the-prevention-of-bleeding
#12
REVIEW
Lise J Estcourt, Reem Malouf, Sally Hopewell, Marialena Trivella, Carolyn Doree, Simon J Stanworth, Michael F Murphy
BACKGROUND: Platelet transfusions are used to prevent and treat bleeding in people who are thrombocytopenic. Despite improvements in donor screening and laboratory testing, a small risk of viral, bacterial, or protozoal contamination of platelets remains. There is also an ongoing risk from newly emerging blood transfusion-transmitted infections for which laboratory tests may not be available at the time of initial outbreak.One solution to reduce the risk of blood transfusion-transmitted infections from platelet transfusion is photochemical pathogen reduction, in which pathogens are either inactivated or significantly depleted in number, thereby reducing the chance of transmission...
July 30, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28738007/comparison-of-intraosseous-pentobarbital-administration-and-thoracic-compression-for-euthanasia-of-anesthetized-sparrows-passer-domesticus-and-starlings-sturnus-vulgaris
#13
Joanne R Paul-Murphy, Andrew Engilis, Peter J Pascoe, D Colette Williams, Kate A Gustavsen, Tracy L Drazenovich, M Kevin Keel, Tamsen M Polley, Irene E Engilis
OBJECTIVE To compare intraosseous pentobarbital treatment (IPT) and thoracic compression (TC) on time to circulatory arrest and an isoelectric electroencephalogram (EEG) in anesthetized passerine birds. ANIMALS 30 wild-caught adult birds (17 house sparrows [Passer domesticus] and 13 European starlings [Sturnus vulgaris]). PROCEDURES Birds were assigned to receive IPT or TC (n = 6/species/group). Birds were anesthetized, and carotid arterial pulses were monitored by Doppler methodology. Five subdermal braided-wire electrodes were used for EEG...
August 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28727607/new-onset-heart-failure-and-mortality-in-hospital-survivors-of-sepsis-related-left-ventricular-dysfunction
#14
Saraschandra Vallabhajosyula, Jacob C Jentzer, Jeffrey B Geske, Mukesh Kumar, Ankit Sakhuja, Akhil Singhal, Joseph T Poterucha, Kianoush Kashani, Joseph G Murphy, Ognjen Gajic, Rahul Kashyap
BACKGROUND: The association between new-onset left ventricular (LV) dysfunction during sepsis with long-term heart failure outcomes is lesser understood. METHODS: Retrospective cohort study of all adult patients with severe sepsis and septic shock between 2007 and 2014 that underwent echocardiography within 72 hours admitted to the intensive care unit. Patients with prior heart failure, LV dysfunction, and structural heart disease were excluded. LV systolic dysfunction was defined as LV ejection fraction <50% and LV diastolic dysfunction as ≥grade II...
July 19, 2017: Shock
https://www.readbyqxmd.com/read/28706127/percutaneous-mechanical-circulatory-support-for-cardiac-disease-temporal-trends-in-use-and-complications-between-2009-and-2015
#15
Bradley W Ternus, Jacob C Jentzer, Abdallah El Sabbagh, Mackram F Eleid, Malcolm R Bell, Joseph G Murphy, Charanjit S Rihal, Gregory W Barsness
BACKGROUND: We present the indications for use, temporal trends, complications, and 1-year clinical outcomes after single-access percutaneous mechanical circulatory support device placement from years 2009-2015 at our institution. METHODS AND RESULTS: Patients with an intraaortic balloon pump (IABP) or Impella device placed in the catheterization suite between January 1, 2009 and December 31, 2015 were included. There were a total of 778 patients in this study. The mean number of devices placed per year was 111...
July 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28702716/can-the-pulmonary-artery-wedge-pressure-be-used-reliably-as-a-surrogate-for-the-left-atrial-mean-pressure-in-pre-fontan-evaluation
#16
Bassel Mohammad Nijres, Ra-Id Abdulla, Sawsan Awad, Joshua Murphy
The correlation between mean pulmonary artery wedge pressure (PAWP) and left atrial mean pressure (LAMP) has been poorly studied in patients with single ventricle (SV) physiology (Bernstein et al. in Pediatr Cardiol 33: 15-20 2012). The aim of this study is to determine if the PAWP can be used safely as a surrogate to the LAMP to calculate the pulmonary vascular resistance (PVR) during the pre-Fontan evaluation. Also, we aimed to understand if the presence of significant systemic-to-pulmonary collaterals (SPCs) is a confounding factor for accurate estimation of the LAMP...
July 12, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28687597/accumulation-of-mitochondrial-dna-mutations-disrupts-cardiac-progenitor-cell-function-and-reduces-survival
#17
Amabel M Orogo, Eileen R Gonzalez, Dieter A Kubli, Igor L Baptista, Sang-Bing Ong, Tomas A Prolla, Mark A Sussman, Anne N Murphy, Åsa B Gustafsson
No abstract text is available yet for this article.
July 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28685982/how-should-training-in-pediatric-cardiac-anesthetic-training-be-undertaken-and-in-what-sort-of-centers
#18
EDITORIAL
Tim Murphy, Ian A Jenkins
No abstract text is available yet for this article.
August 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28685271/direct-and-indirect-effects-of-age-on-interoceptive-accuracy-and-awareness-across-the-adult-lifespan
#19
Jennifer Murphy, Hayley Geary, Edward Millgate, Caroline Catmur, Geoffrey Bird
Various aspects of physical and mental health have been linked to an individual's ability to perceive the physical condition of their body ('interoception'). In addition, numerous studies have demonstrated a role for interoception in higher-order cognitive abilities such as decision-making and emotion processing. The importance of interoception for health and typical cognitive functioning has prompted interest in how interoception varies over the lifespan. However, few studies have investigated interoception into older adulthood, and no studies account for the set of physiological changes that may influence task performance...
July 6, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28657278/interarterial-left-circumflex-the-forgotten-coronary-artery-anomaly
#20
D J Murphy, A R Keraliya, A Aghayev, M L Steigner
Anomalous coronary artery origin is a rare, but important cause of cardiac ischemia, particularly in younger patients. These anomalies of origin can be divided into two groups, benign or malignant, based on their propensity to cause ischemia or sudden death. Symptomatic, or malignant coronary artery anomalies are usually described with respect to anomalous origins of the right coronary artery or left main coronary artery. We present a unique case of a previously unreported entity, an anomalous left circumflex coronary artery causing ischemia...
January 11, 2017: Irish Medical Journal
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