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https://www.readbyqxmd.com/read/28738007/comparison-of-intraosseous-pentobarbital-administration-and-thoracic-compression-for-euthanasia-of-anesthetized-sparrows-passer-domesticus-and-starlings-sturnus-vulgaris
#1
Joanne R Paul-Murphy, Andrew Engilis, Peter J Pascoe, D Colette Williams, Kate A Gustavsen, Tracy L Drazenovich, M Kevin Keel, Tamsen M Polley, Irene E Engilis
OBJECTIVE To compare intraosseous pentobarbital treatment (IPT) and thoracic compression (TC) on time to circulatory arrest and an isoelectric electroencephalogram (EEG) in anesthetized passerine birds. ANIMALS 30 wild-caught adult birds (17 house sparrows [Passer domesticus] and 13 European starlings [Sturnus vulgaris]). PROCEDURES Birds were assigned to receive IPT or TC (n = 6/species/group). Birds were anesthetized, and carotid arterial pulses were monitored by Doppler methodology. Five subdermal braided-wire electrodes were used for EEG...
August 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28727607/new-onset-heart-failure-and-mortality-in-hospital-survivors-of-sepsis-related-left-ventricular-dysfunction
#2
Saraschandra Vallabhajosyula, Jacob C Jentzer, Jeffrey B Geske, Mukesh Kumar, Ankit Sakhuja, Akhil Singhal, Joseph T Poterucha, Kianoush Kashani, Joseph G Murphy, Ognjen Gajic, Rahul Kashyap
BACKGROUND: The association between new-onset left ventricular (LV) dysfunction during sepsis with long-term heart failure outcomes is lesser understood. METHODS: Retrospective cohort study of all adult patients with severe sepsis and septic shock between 2007 and 2014 that underwent echocardiography within 72 hours admitted to the intensive care unit. Patients with prior heart failure, LV dysfunction, and structural heart disease were excluded. LV systolic dysfunction was defined as LV ejection fraction <50% and LV diastolic dysfunction as ≥grade II...
July 19, 2017: Shock
https://www.readbyqxmd.com/read/28706127/percutaneous-mechanical-circulatory-support-for-cardiac-disease-temporal-trends-in-use-and-complications-between-2009-and-2015
#3
Bradley W Ternus, Jacob C Jentzer, Abdallah El Sabbagh, Mackram F Eleid, Malcolm R Bell, Joseph G Murphy, Charanjit S Rihal, Gregory W Barsness
BACKGROUND: We present the indications for use, temporal trends, complications, and 1-year clinical outcomes after single-access percutaneous mechanical circulatory support device placement from years 2009-2015 at our institution. METHODS AND RESULTS: Patients with an intraaortic balloon pump (IABP) or Impella device placed in the catheterization suite between January 1, 2009 and December 31, 2015 were included. There were a total of 778 patients in this study. The mean number of devices placed per year was 111...
July 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28702716/can-the-pulmonary-artery-wedge-pressure-be-used-reliably-as-a-surrogate-for-the-left-atrial-mean-pressure-in-pre-fontan-evaluation
#4
Bassel Mohammad Nijres, Ra-Id Abdulla, Sawsan Awad, Joshua Murphy
The correlation between mean pulmonary artery wedge pressure (PAWP) and left atrial mean pressure (LAMP) has been poorly studied in patients with single ventricle (SV) physiology (Bernstein et al. in Pediatr Cardiol 33: 15-20 2012). The aim of this study is to determine if the PAWP can be used safely as a surrogate to the LAMP to calculate the pulmonary vascular resistance (PVR) during the pre-Fontan evaluation. Also, we aimed to understand if the presence of significant systemic-to-pulmonary collaterals (SPCs) is a confounding factor for accurate estimation of the LAMP...
July 12, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28687597/accumulation-of-mitochondrial-dna-mutations-disrupts-cardiac-progenitor-cell-function-and-reduces-survival
#5
Amabel M Orogo, Eileen R Gonzalez, Dieter A Kubli, Igor L Baptista, Sang-Bing Ong, Tomas A Prolla, Mark A Sussman, Anne N Murphy, Åsa B Gustafsson
No abstract text is available yet for this article.
July 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28685982/how-should-training-in-pediatric-cardiac-anesthetic-training-be-undertaken-and-in-what-sort-of-centers
#6
EDITORIAL
Tim Murphy, Ian A Jenkins
No abstract text is available yet for this article.
August 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28685271/direct-and-indirect-effects-of-age-on-interoceptive-accuracy-and-awareness-across-the-adult-lifespan
#7
Jennifer Murphy, Hayley Geary, Edward Millgate, Caroline Catmur, Geoffrey Bird
Various aspects of physical and mental health have been linked to an individual's ability to perceive the physical condition of their body ('interoception'). In addition, numerous studies have demonstrated a role for interoception in higher-order cognitive abilities such as decision-making and emotion processing. The importance of interoception for health and typical cognitive functioning has prompted interest in how interoception varies over the lifespan. However, few studies have investigated interoception into older adulthood, and no studies account for the set of physiological changes that may influence task performance...
July 6, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28657278/interarterial-left-circumflex-the-forgotten-coronary-artery-anomaly
#8
D J Murphy, A R Keraliya, A Aghayev, M L Steigner
Anomalous coronary artery origin is a rare, but important cause of cardiac ischemia, particularly in younger patients. These anomalies of origin can be divided into two groups, benign or malignant, based on their propensity to cause ischemia or sudden death. Symptomatic, or malignant coronary artery anomalies are usually described with respect to anomalous origins of the right coronary artery or left main coronary artery. We present a unique case of a previously unreported entity, an anomalous left circumflex coronary artery causing ischemia...
January 11, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/28655755/out-of-hospital-cardiac-arrests-in-the-older-population-in-ireland
#9
Richard Tanner, Siobhan Masterson, Mette Jensen, Peter Wright, David Hennelly, Martin O'Reilly, Andrew W Murphy, Gerard Bury, Cathal O'Donnell, Conor Deasy
INTRODUCTION: Age influences survival from an out-of-hospital cardiac arrest (OHCA) but it is unclear to what extent. Improved understanding of the impact of increasing age may be helpful in improving decision making on who should receive attempted resuscitation to optimise outcomes and minimise inappropriate end-of-life management. Our aim is to describe the demographics, characteristics and outcomes following resuscitation attempts in OHCA patients aged 70 years and older in Ireland...
June 27, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28635973/deconstructing-decisions-to-initiate-maintain-or-discontinue-adjuvant-endocrine-therapy-in-breast-cancer-survivors-a-mixed-methods-study
#10
Shirley M Bluethmann, Caitlin C Murphy, Jasmin A Tiro, Michelle A Mollica, Sally W Vernon, Leona Kay Bartholomew
PURPOSE/OBJECTIVES: Adjuvant endocrine therapy (AET) has been shown to improve survival in hormone receptor-positive breast cancer survivors, but as many as half do not complete recommended treatment. Management of medication-related side effects and engagement with providers are two potentially modifiable factors, but their associations with adherence are not well understood. The aims were to build on survey results to qualitatively explore survivors' experiences with prescribed AET to (a) describe appraisal and management of AET side effects and (b) deconstruct decisions to initiate, discontinue, or maintain AET...
May 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28615162/characterization-of-muscle-ankyrin-repeat-proteins-in-human-skeletal-muscle
#11
Stefan G Wette, Heather K Smith, Graham D Lamb, Robyn M Murphy
Muscle Ankyrin Repeat Proteins (MARPs) are a family of titin-associated stress response molecules and putative transducers of stretch-induced signalling in skeletal muscle. In cardiac muscle, Cardiac Ankyrin Repeat Protein (CARP) and Diabetes-Related Ankyrin Repeat Protein (DARP) reportedly redistribute from binding sites on titin to the nucleus following prolonged stretch. However, it is unclear whether Ankyrin repeat-domain protein2 (Ankrd2) shows comparable stretch-induced redistribution to the nucleus. We measured in rested human skeletal muscle 1) the absolute amount of MARPs, and 2) the distribution of Ankrd2 and DARP in both single fibers and whole muscle preparations...
June 14, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28613933/quantification-of-radiation-dose-reduction-by-reducing-z-axis-coverage-in-320-detector-coronary-ct-angiography
#12
D J Murphy, A Keraliya, N Himes, A Aghayev, R Blankstein, M L Steigner
OBJECTIVES: To quantify the radiation dose reduction achievable by minimizing z-axis coverage in 320-detector coronary computed tomography angiography (CCTA). METHODS: We retrospectively reviewed 130 CCTAs performed on 320-detector CT that offers up to 16cm z-axis coverage (adjustable in 2cm increments), allowing complete coverage of the heart in a single gantry rotation. For each CT we obtained the radiation dose (CTDIvol and DLP), measured the z-axis field of view and measured the craniocaudal cardiac size (distance from the left main coronary artery to the cardiac apex)...
June 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28526246/impaired-mitophagy-facilitates-mitochondrial-damage-in-danon-disease
#13
Sherin I Hashem, Anne N Murphy, Ajit S Divakaruni, Matthew L Klos, Bradley C Nelson, Emily C Gault, Teisha J Rowland, Cynthia N Perry, Yusu Gu, Nancy D Dalton, William H Bradford, Eric J Devaney, Kirk L Peterson, Kenneth L Jones, Matthew R G Taylor, Ju Chen, Neil C Chi, Eric D Adler
RATIONALE: Lysosomal associated membrane protein type-2 (LAMP-2) is a highly conserved, ubiquitous protein that is critical for autophagic flux. Loss of function mutations in the LAMP-2 gene cause Danon disease, a rare X-linked disorder characterized by developmental delay, skeletal muscle weakness, and severe cardiomyopathy. We previously found that human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from Danon patients exhibited significant mitochondrial oxidative stress and apoptosis...
May 16, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28523441/progress-in-the-presence-of-failure-updates-in-chronic-systolic-heart-failure-management
#14
REVIEW
Katie M Murphy, Julie L Rosenthal
The therapeutic heart failure armamentarium has evolved from drugs to transplantation to devices through further understanding of its complex pathophysiology and pathogenesis. Current medications capitalize on our evolving understanding of the sympathetic and renin-angiotensin-aldosterone systems that subsequently promote both beneficial and maladaptive responses that ultimately yield a decrease in cardiac function. Despite these advancements, the prevalence of heart failure continues to rise and carries a significant burden on our patients and health care system...
July 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28522833/parkin-regulation-of-chop-modulates-susceptibility-to-cardiac-endoplasmic-reticulum-stress
#15
Kim Han, Shahin Hassanzadeh, Komudi Singh, Sara Menazza, Tiffany T Nguyen, Mark V Stevens, An Nguyen, Hong San, Stasia A Anderson, Yongshun Lin, Jizhong Zou, Elizabeth Murphy, Michael N Sack
The regulatory control of cardiac endoplasmic reticulum (ER) stress is incompletely characterized. As ER stress signaling upregulates the E3-ubiquitin ligase Parkin, we investigated the role of Parkin in cardiac ER stress. Parkin knockout mice exposed to aortic constriction-induced cardiac pressure-overload or in response to systemic tunicamycin (TM) developed adverse ventricular remodeling with excessive levels of the ER regulatory C/EBP homologous protein CHOP. CHOP was identified as a Parkin substrate and its turnover was Parkin-dose and proteasome-dependent...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28499519/association-between-sexual-problems-and-relationship-satisfaction-among-people-with-cardiovascular-disease
#16
Molly Byrne, Patrick Murphy, Maureen D'Eath, Sally Doherty, Tiny Jaarsma
BACKGROUND: Relationship satisfaction is generally positively correlated with sexual satisfaction, but this relation has been poorly examined in people with cardiovascular disease who are at increased risk of sexual problems compared with the general population. AIM: To document reported changes to sex after a diagnosis of cardiac disease and determine whether there is an association between sexual function and relationship satisfaction. METHODS: Semistructured telephone interviews focused on relationship satisfaction and sexual problems were conducted with 201 people with cardiovascular disease who were currently in a sexual relationship with one main partner and were recruited from six hospital cardiac rehabilitation centers in Ireland...
May 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28475670/randomized-trial-of-red-cell-washing-for-the-prevention-of-transfusion-associated-organ-injury-in-cardiac-surgery
#17
M J Wozniak, N Sullo, S Qureshi, W Dott, R Cardigan, M Wiltshire, T Morris, M Nath, N Bittar, S K Bhudia, T Kumar, A H Goodall, G J Murphy
Background: Experimental studies suggest that mechanical cell washing to remove pro-inflammatory components that accumulate in the supernatant of stored donor red blood cells (RBCs) might reduce inflammation and organ injury in transfused patients. Methods: Cardiac surgery patients at increased risk of large-volume RBC transfusion were eligible. Participants were randomized to receive either mechanically washed allogenic RBCs or standard care RBCs. The primary outcome was serum interleukin-8 measured at baseline and at four postsurgery time points...
May 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28475665/routine-use-of-viscoelastic-blood-tests-for-diagnosis-and-treatment-of-coagulopathic-bleeding-in-cardiac-surgery-updated-systematic-review-and-meta-analysis
#18
G F Serraino, G J Murphy
Viscoelastic point-of-care tests are commonly used to provide prompt diagnosis of coagulopathy and allow targeted treatments in bleeding patients. We updated existing meta-analyses that have evaluated the clinical effectiveness of viscoelastic point-of-care tests vs the current standard of care for the management of cardiac surgery patients at risk of coagulopathic bleeding. Randomized controlled trials comparing viscoelastic point-of-care diagnostic testing with standard care in cardiac surgery patients were sought...
June 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28457941/non-nuclear-estrogen-receptor-alpha-activation-in-endothelium-reduces-cardiac-ischemia-reperfusion-injury-in-mice
#19
Sara Menazza, Junhui Sun, Swathi Appachi, Ken L Chambliss, Sung Hoon Kim, Angel Aponte, Sohaib Khan, John A Katzenellenbogen, Benita S Katzenellenbogen, Philip W Shaul, Elizabeth Murphy
Steroid hormone receptors including estrogen receptors (ER) classically function as ligand-regulated transcription factors. However, estrogens also elicit cellular effects through binding to extra-nuclear ER (ERα, ERβ, and G protein-coupled ER or GPER) that are coupled to kinases. How extra-nuclear ER actions impact cardiac ischemia-reperfusion (I/R) injury is unknown. We treated ovariectomized wild-type female mice with estradiol or an estrogen-dendrimer conjugate (EDC), which selectively activates extra-nuclear ER, or vehicle interventions for two weeks...
June 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28448298/anesthetic-consideration-for-neuromuscular-diseases
#20
Jeffery A Katz, Glenn S Murphy
PURPOSE OF REVIEW: The aim of this review is to examine data relating to perioperative management of the patient with neuromuscular disorders RECENT FINDINGS: Patients with pre-existing neuromuscular disorders are at risk for a number of postoperative complications that are related to anesthetic drugs that are administered intraoperatively. Careful preoperative assessment is necessary to reduce morbidity and mortality. In particular, the risk of postoperative respiratory failure and need for long-term ventilation should be reviewed with patients...
June 2017: Current Opinion in Anaesthesiology
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