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https://www.readbyqxmd.com/read/29122559/constant-hepatic-atp-concentrations-during-prolonged-fasting-and-absence-of-effects-of-cerbomed-nemos-%C3%A2-on-parasympathetic-tone-and-hepatic-energy-metabolism
#1
Sofiya Gancheva, Alessandra Bierwagen, Daniel F Markgraf, Gidon J Bönhof, Kevin G Murphy, Erifili Hatziagelaki, Jesper Lundbom, Dan Ziegler, Michael Roden
OBJECTIVE: Brain insulin-induced improvement in glucose homeostasis has been proposed to be mediated by the parasympathetic nervous system. Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) activating afferent branches of the vagus nerve may prevent hyperglycemia in diabetes models. We examined the effects of 14-min taVNS vs sham stimulation by Cerbomed Nemos(®) on glucose metabolism, lipids, and hepatic energy homeostasis in fasted healthy humans (n = 10, age 51 ± 6 yrs, BMI 25...
October 25, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29102981/use-of-cardiac-computerized-tomography-to-predict-neo-left-ventricular-outflow-tract-obstruction-before-transcatheter-mitral-valve-replacement
#2
REVIEW
David J Murphy, Yin Ge, Creighton W Don, Abhishek Keraliya, Ayaz Aghayev, Roisin Morgan, Benjamin Galper, Deepak L Bhatt, Tsuyoshi Kaneko, Marcelo Di Carli, Pinak Shah, Michael Steigner, Ron Blankstein
No abstract text is available yet for this article.
November 4, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29100840/cardiac-rehabilitation-in-australia-a-brief-survey-of-program-characteristics
#3
Alun C Jackson, Rosemary O Higgins, Barbara M Murphy, Michelle Rogerson, Michael R Le Grande
BACKGROUND: Defining cardiac rehabilitation (CR) program characteristics on a national, level is crucial for decision-making on resource allocation and evaluation of service quality. Comprehensive surveys of CR programs have been conducted overseas, but, to date, no such profile had been conducted in Australia. METHODS: A representative sample of 165 CR programs across Australia were asked to provide details on a range of program characteristics such as program location and size, program elements, and staffing profile...
September 28, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29092915/trial-registration-and-adherence-to-reporting-guidelines-in-cardiovascular-journals
#4
Matt Thomas Sims, Aaron Marc Bowers, Jamie Morgan Fernan, Kody Duane Dormire, James Murphy Herrington, Matt Vassar
OBJECTIVE: This study investigated the policies of cardiac and cardiovascular system journals concerning clinical trial registration and guideline adoption to understand how frequently journals use these mechanisms to improve transparency, trial reporting and overall study quality. METHODS: We selected the top 20 (by impact factor) journals cited in the subcategory 'Cardiac and Cardiovascular Systems' of the Expanded Science Citation Index of the 2014 Journal Citation Reports to extract journal policies concerning the 17 guidelines we identified...
November 1, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29053016/sudden-death-neurogenic-causes-prediction-and-prevention
#5
Nina Japundžić-Žigon, Olivera Šarenac, Maja Lozić, Marko Vasić, Tatjana Tasić, Dragana Bajić, Vladimir Kanjuh, David Murphy
Sudden death is a major health problem all over the world. The most common causes of sudden death are cardiac but there are also other causes such as neurological conditions (stroke, epileptic attacks and brain trauma), drugs, catecholamine toxicity, etc. A common feature of all these diverse pathologies underlying sudden death is the imbalance of the autonomic nervous system control of the cardiovascular system. This paper reviews different pathologies underlying sudden death with emphasis on the autonomic nervous system contribution, possibilities of early diagnosis and prognosis of sudden death using various clinical markers including autonomic markers (heart rate variability and baroreflex sensitivity), present possibilities of management and promising prevention by electrical neuromodulation...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29051185/cgmp-elevating-compounds-and-ischemic-conditioning-provide-cardioprotection-against-ischemia-and-reperfusion-injury-via-cardiomyocyte-specific-bk-channels
#6
Sandra Frankenreiter, Piotr Bednarczyk, Angelina Kniess, Nadja Bork, Julia Straubinger, Piotr Koprowski, Antoni Wrzosek, Eva Mohr, Angela Logan, Michael P Murphy, Meinrad Gawaz, Thomas Krieg, Adam Szewczyk, Viacheslav O Nikolaev, Peter Ruth, Robert Lukowski
Background -The nitric oxide-sensitive guanylyl cyclase (NO-GC)/cyclic guanosine-3',5'-monophosphate (cGMP)/cGMP-dependent protein kinase type I (cGKI)-signaling pathway can afford protection against the ischemia and reperfusion (I/R) injury that occurs during myocardial infarction (MI). Reportedly, voltage and Ca(2+)-activated K(+) channels of the BK-type are stimulated by cGMP/cGKI and recent ex-vivo studies implicated that increased BK activity favors the survival of the myocardium at I/R. It remains unclear, however, whether the molecular events downstream of cGMP involve BK channels present in cardiomyocytes (CMs) or in other cardiac cell types...
October 19, 2017: Circulation
https://www.readbyqxmd.com/read/29034473/development-and-maturation-of-the-fibrous-components-of-the-arterial-roots-in-the-mouse-heart
#7
Rachel Richardson, Lorraine Eley, Charlotte Donald-Wilson, Jonathon Davis, Natasha Curley, Ahlam Alqahtani, Lindsay Murphy, Robert H Anderson, Deborah J Henderson, Bill Chaudhry
The arterial roots are important transitional regions of the heart, connecting the intrapericardial components of the aortic and pulmonary trunks with their ventricular outlets. They house the arterial (semilunar) valves and, in the case of the aorta, are the points of coronary arterial attachment. Moreover, because of the semilunar attachments of the valve leaflets, the arterial roots span the anatomic ventriculo-arterial junction. By virtue of this arrangement, the interleaflet triangles, despite being fibrous, are found on the ventricular aspect of the root and located within the left ventricular cavity...
October 15, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28979923/isolation-of-mouse-cardiac-neural-crest-cells-and-their-differentiation-into-smooth-muscle-cells
#8
Xia Wang, Sophie Astrof
Cardiac neural crest cells (CNCCs) originate at the dorsal edge of the neural tube between the otic pit and the caudal edge of the 3(rd) somite, and migrate into the pharyngeal arches and the heart. We have shown that fibronectin (Fn1) plays an important role in the development of the CNCC by regulating the differentiation of CNCCs into vascular smooth muscle cells around pharyngeal arch arteries (Wang and Astrof, 2016). This protocol describes the isolation of CNCCs from the neural tube and from the caudal pharyngeal arches, and the differentiation of neural crest-derived cells into smooth muscle cells...
September 5, 2017: Bio-protocol
https://www.readbyqxmd.com/read/28969313/randomized-trial-of-near-infrared-spectroscopy-for-personalized-optimization-of-cerebral-tissue-oxygenation-during-cardiac-surgery
#9
C A Rogers, S Stoica, L Ellis, E A Stokes, S Wordsworth, L Dabner, G Clayton, R Downes, E Nicholson, S Bennett, G D Angelini, B C Reeves, G J Murphy
Background: We assessed whether a near-infrared spectroscopy (NIRS)-based algorithm for the personalized optimization of cerebral oxygenation during cardiopulmonary bypass combined with a restrictive red cell transfusion threshold would reduce perioperative injury to the brain, heart, and kidneys. Methods: In a randomized controlled trial, participants in three UK centres were randomized with concealed allocation to a NIRS (INVOS 5100; Medtronic Inc., Minneapolis, MN, USA)-based 'patient-specific' algorithm that included a restrictive red cell transfusion threshold (haematocrit 18%) or to a 'generic' non-NIRS-based algorithm (standard care)...
September 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28964164/sensitivity-of-reentrant-driver-localization-to-electrophysiological-parameter-variability-in-image-based-computational-models-of-persistent-atrial-fibrillation-sustained-by-a-fibrotic-substrate
#10
Dongdong Deng, Michael J Murphy, Joe B Hakim, William H Franceschi, Sohail Zahid, Farhad Pashakhanloo, Natalia A Trayanova, Patrick M Boyle
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, causing morbidity and mortality in millions worldwide. The atria of patients with persistent AF (PsAF) are characterized by the presence of extensive and distributed atrial fibrosis, which facilitates the formation of persistent reentrant drivers (RDs, i.e., spiral waves), which promote fibrillatory activity. Targeted catheter ablation of RD-harboring tissues has shown promise as a clinical treatment for PsAF, but the outcomes remain sub-par...
September 2017: Chaos
https://www.readbyqxmd.com/read/28942397/catastrophic-cement-reaction-following-cementation-for-megaprosthesis-for-proximal-femoral-fracture
#11
Muhammad Nouman Baig, William Curtin, Michael Andrew Callaghan, Colin G Murphy
Bone cement implantation syndrome (BCIS) is a well-described and potentially fatal complication of orthopaedic surgery involving pressurised bone cement. Although also described for certain spinal procedures, it is most commonly associated with cemented hip and knee arthroplasty and with cemented hemiarthroplasty following neck of femur fracture in particular.Donaldson et alproposed the definition of BCIS as a syndrome "characterized by hypoxia, hypotension or both and/or unexpected loss of consciousness occurring around the time of cementation, prosthesis insertion, reduction of the joint or, occasionally, limb tourniquet deflation in a patient undergoing cemented bone surgery"...
September 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28905517/the-prognostic-significance-of-tricuspid-valve-regurgitation-in-pulmonary-arterial-hypertension
#12
Libo Chen, Carolyn M Larsen, Rachel J Le, Heidi M Connolly, Sorin V Pislaru, Joseph G Murphy, Michael D McGoon, Robert P Frantz, Garvan C Kane
INTRODUCTION: Tricuspid valve regurgitation (TR) is a frequent finding in patients with pulmonary arterial hypertension (PAH). However, its prognostic significance and relation to PAH, while suspected, are poorly understood. We assessed 727 consecutive patients with newly diagnosed PAH who underwent transthoracic echocardiographic evaluation of tricuspid valve function. OBJECTIVES: The study objective was to determine the association of TR presence and severity with patient characteristics, pulmonary artery hemodynamics, and outcome...
September 14, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28899987/heart-failure-related-hyperphosphorylation-in-the-cardiac-troponin-i-c-terminus-has-divergent-effects-on-cardiac-function-in-vivo
#13
Yuejin Li, Guangshuo Zhu, Nazareno Paolocci, Pingbo Zhang, Cyrus Takahashi, Nazli Okumus, Amir Heravi, Gizem Keceli, Genaro Ramirez-Correa, David A Kass, Anne M Murphy
BACKGROUND: In human heart failure, Ser199 (equivalent to Ser200 in mouse) of cTnI (cardiac troponin I) is significantly hyperphosphorylated, and in vitro studies suggest that it enhances myofilament calcium sensitivity and alters calpain-mediated cTnI proteolysis. However, how its hyperphosphorylation affects cardiac function in vivo remains unknown. METHODS AND RESULTS: To address the question, 2 transgenic mouse models were generated: a phospho-mimetic cTnIS200D and a phospho-silenced cTnIS200A, each driven by the cardiomyocyte-specific α-myosin heavy chain promoter...
September 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28882917/effects-of-cerebral-near-infrared-spectroscopy-on-the-outcome-of-patients-undergoing-cardiac-surgery-a-systematic-review-of-randomised-trials
#14
Giuseppe Filiberto Serraino, Gavin J Murphy
OBJECTIVES: Goal-directed optimisation of cerebral oxygenation using near-infrared spectroscopy (NIRS) during cardiopulmonary bypass is widely used. We tested the hypotheses that the use of NIRS cerebral oximetry results in reductions in cerebral injury (neurocognitive function, serum biomarkers), injury to other organs including the heart and brain, transfusion rates, mortality and resource use. DESIGN: Systematic review and meta-analysis. SETTING: Tertiary cardiac surgery centres in North America, Europe and Asia...
September 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28863430/obesity-protects-during-cardiac-surgery-professor-gavin-murphy-speaks-to-mark-nicholls-about-a-study-that-could-turn-conventional-thinking-of-a-patient-s-weight-cardiac-health-and-surgery-on-its-head
#15
https://www.readbyqxmd.com/read/28862954/a-systems-biology-approach-to-investigating-sex-differences-in-cardiac-hypertrophy
#16
Josephine Harrington, Natasha Fillmore, Shouguo Gao, Yanqin Yang, Xue Zhang, Poching Liu, Andrea Stoehr, Ye Chen, Danielle Springer, Jun Zhu, Xujing Wang, Elizabeth Murphy
BACKGROUND: Heart failure preceded by hypertrophy is a leading cause of death, and sex differences in hypertrophy are well known, although the basis for these sex differences is poorly understood. METHODS AND RESULTS: This study used a systems biology approach to investigate mechanisms underlying sex differences in cardiac hypertrophy. Male and female mice were treated for 2 and 3 weeks with angiotensin II to induce hypertrophy. Sex differences in cardiac hypertrophy were apparent after 3 weeks of treatment...
August 19, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28846437/oxygen-administration-improves-survival-but-worsens-cardiopulmonary-functions-in-chlorine-exposed-rats
#17
Obiefuna C Okponyia, Matthew D McGraw, Marilyn M Dysart, Rhonda B Garlick, Jacqueline S Rioux, Angela L Murphy, Gates B Roe, Carl W White, Livia A Veress
RATIONALE: Chlorine is a highly reactive gas that can cause significant injury when inhaled. Unfortunately, its use as a chemical weapon has increased in recent years. Massive chlorine inhalation can cause death within 4h of exposure. Survivors usually require hospitalization after massive exposure. No countermeasures exist for massive chlorine exposure, and supportive care measures lack controlled trials. METHODS: Adult rats were exposed to chlorine gas (LD58-67) in a whole-body exposure chamber, and given oxygen (0...
August 28, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28842929/the-effect-of-rurality-on-out-of-hospital-cardiac-arrest-resuscitation-incidence-an-exploratory-study-of-a-national-registry-utilizing-a-categorical-approach
#18
Siobhán Masterson, Conor Teljeur, John Cullinan, Andrew W Murphy, Conor Deasy, Akke Vellinga
PURPOSE: Variation in incidence is a universal feature of out-of-hospital cardiac arrest (OHCA). One potential source of variation is the rurality of the location where the OHCA incident occurs. While previous work has used a simple binary approach to define rurality, the purpose of this study was to use a categorical approach to quantify the impact of urban-rural classification on OHCA incidence in the Republic of Ireland. METHODS: The observed versus expected ratio of OHCA incidence where resuscitation was attempted for the period January 1, 2012, to December 31, 2014, was calculated for each of the 3,408 electoral divisions (ED)...
August 26, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/28826760/evidence-based-red-blood-cell-transfusion-practices-in-cardiac-surgery
#19
REVIEW
Nishith N Patel, Gavin J Murphy
Cardiac surgical patients are among the highest consumers of allogeneic red blood cells (RBCs) due to the prevalence of anemia and bleeding. Up until recently, there was a paucity of high-quality evidence informing transfusion decisions in this patient group which led to wide variability in transfusion decision making. The article reviews and critically analyzes the available evidence for RBC transfusion in cardiac surgery, focusing on trials of transfusion triggers and age of blood, and provides suggestions for future research...
October 2017: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28805027/acute-and-midterm-results-following-perventricular-device-closure-of-muscular-ventricular-septal-defects-a-multicenter-pices-investigation
#20
Robert G Gray, Shaji C Menon, Joyce T Johnson, Aimee K Armstrong, Michael A Bingler, John P Breinholt, Damien Kenny, John Lozier, Joshua J Murphy, Shyam K Sathanandam, Nathaniel W Taggart, Sara M Trucco, Bryan H Goldstein, Brent M Gordon
OBJECTIVES: To describe acute and mid-term results of hybrid perventricular device closure of muscular ventricular septal defects (mVSDs). BACKGROUND: Perventricular device closure of mVSDs can mitigate technical limitations of percutaneous closure and need for cardiopulmonary bypass or ventriculotomy with a surgical approach. METHODS: This is a multicenter retrospective cohort study of patients undergoing hybrid perventricular mVSD device closure from 1/2004 to 1/2014...
August 1, 2017: Catheterization and Cardiovascular Interventions
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