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Morris Emory

Eric Y Shin, Patricia Ochuko, Kunal Bhatt, Brian Howard, Gerard McGorisk, Linda Delaney, Kristan Langdon, Marjan Khosravanipour, Andiran A Nambi, Allison Grahovec, Douglas C Morris, Penny Z Castellano, Leslee J Shaw, Laurence S Sperling, Abhinav Goyal
BACKGROUND: With the recent implementation of the Medicare Quality Payment Program, providers face increasing accountability for delivering high-quality care. Such pay-for-performance programs aim to leverage systematic data captured by electronic health record (EHR) systems to measure performance; however, the fidelity of EHR query for assessing performance has not been validated compared with manual chart review. We sought to determine whether our institution's methodology of EHR query could accurately identify cases in which providers failed to prescribe statins for eligible patients with coronary artery disease...
April 12, 2018: Journal of the American Heart Association
Robert Townsend Cole, Jonathan Gandhi, Robert A Bray, Howard M Gebel, Michael Yin, Nikolaz Shekiladze, An Young, Aubrey Grant, Ian Mahoney, S Raja Laskar, Divya Gupta, Kunal Bhatt, Wendy Book, Andrew Smith, Duc Nguyen, J David Vega, Alanna A Morris
BACKGROUND: Despite improvements in outcomes after heart transplantation, black recipients have worse survival compared with non-black recipients. The source of such disparate outcomes remains largely unknown. We hypothesize that a propensity to generate de-novo donor-specific antibodies (dnDSA) and subsequent antibody-mediated rejection (AMR) may account for racial differences in sub-optimal outcomes after heart transplant. In this study we aimed to determine the role of dnDSA and AMR in racial disparities in post-transplant outcomes...
April 2018: Journal of Heart and Lung Transplantation
Teresa J Mathews, Allison M Fortner, R Trent Jett, Jesse Morris, Jennifer Gable, Mark J Peterson, Neil Carriker
In December 2008, 4.1 million cubic meters of coal ash were released into the Emory and Clinch Rivers by the Tennessee Valley Authority Kingston Fossil Plant. Coal ash contains several contaminants, including the bioaccumulative metalloid selenium (Se). Because Se is predominantly accumulated in aquatic organisms through dietary rather than aqueous exposure, tissue-based toxicity thresholds for Se are currently being considered. The proposed threshold concentrations range between 4 μg/g and 9 μg/g Se (dry wt...
October 2014: Environmental Toxicology and Chemistry
Joseph Poole, Kreton Mavromatis, José N Binongo, Ali Khan, Qunna Li, Mohamed Khayata, Elizabeth Rocco, Matthew Topel, Xin Zhang, Charlene Brown, Matthew A Corriere, Jonathan Murrow, Salman Sher, Stephanie Clement, Khuram Ashraf, Amr Rashed, Tarek Kabbany, Robert Neuman, Alanna Morris, Arshad Ali, Salim Hayek, John Oshinski, Young-sup Yoon, Edmund K Waller, Arshed A Quyyumi
IMPORTANCE: Many patients with peripheral artery disease (PAD) have walking impairment despite therapy. Experimental studies in animals demonstrate improved perfusion in ischemic hind limb after mobilization of bone marrow progenitor cells (PCs), but whether this is effective in patients with PAD is unknown. OBJECTIVE: To investigate whether therapy with granulocyte-macrophage colony-stimulating factor (GM-CSF) improves exercise capacity in patients with intermittent claudication...
December 25, 2013: JAMA: the Journal of the American Medical Association
Sameer V Nagpal, Stamatios Lerakis, Peter B Flueckiger, Michael Halista, Patrick Willis, Peter C Block, John S Douglas, Douglas C Morris, David A Liff, James Stewart, Chethan Devireddy, Emir Veledar, Fadi B Nahab, Vasilis C Babaliaros
Percutaneous patent foramen ovale (PFO) closure is a treatment for cryptogenic stroke and migraine headache. The goal of this study was to assess long-term outcomes of patients treated with percutaneous PFO closure. Records of patients with percutaneous PFO closure at Emory University Hospital from February 2002 to July 2009 were reviewed. Follow-up telephone questionnaire and chart review assessed recurrent stroke, migraine, and complications. Data was reviewed on 414 consecutive patients. Long-term follow-up was obtained in 207 of patients, and mean follow up was 4...
September 2013: American Journal of the Medical Sciences
Sharath R Cholleti, Sanjay Agravat, Tim Morris, Joel H Saltz, Xuezheng Song, Richard D Cummings, David F Smith
Assessing interactions of a glycan-binding protein (GBP) or lectin with glycans on a microarray generates large datasets, making it difficult to identify a glycan structural motif or determinant associated with the highest apparent binding strength of the GBP. We have developed a computational method, termed GlycanMotifMiner, that uses the relative binding of a GBP with glycans within a glycan microarray to automatically reveal the glycan structural motifs recognized by a GBP. We implemented the software with a web-based graphical interface for users to explore and visualize the discovered motifs...
October 2012: Omics: a Journal of Integrative Biology
Alanna A Morris, Yusuf Ahmed, Neli Stoyanova, William Craig Hooper, Christine De Staerke, Gary Gibbons, Arshed Quyyumi, Viola Vaccarino
OBJECTIVE: Animal models suggest that impaired leptin production, or leptin resistance despite increased leptin levels, may contribute to depression. The link between leptin and depression could be mediated by obesity, which is more common in depression and increases leptin production. METHODS: We administered the Beck Depression Inventory-II (BDI-II) to 537 participants (mean [standard deviation (SD)] age = 51 [9] years; female, 61%) enrolled in the Morehouse and Emory Team up to Eliminate Health Disparities (META-Health) study...
June 2012: Psychosomatic Medicine
Alanna A Morris, Liping Zhao, Riyaz S Patel, Dean P Jones, Yusuf Ahmed, Neli Stoyanova, Gary H Gibbons, Viola Vaccarino, Rebecca Din-Dzietham, Arshed A Quyyumi
BACKGROUND: Classification schema such as metabolic syndrome may underestimate cardiovascular disease (CVD) risk in African Americans, despite a higher burden of CVD in African Americans. Oxidative stress results from an imbalance of prooxidants and antioxidants and leads to endothelial dysfunction that promotes vascular inflammation and atherosclerosis. Aminothiol markers of oxidative stress are associated with CVD risk factors and metabolic syndrome; however, little is known about racial differences in levels of oxidative stress...
August 2012: Metabolic Syndrome and related Disorders
D Jeffrey Newport, Ross J Baldessarini, Bettina T Knight, Susana V Fernandez, Natalie J Morris, Adele C Viguera, Zachary N Stowe
OBJECTIVE: Because bipolar disorder can be difficult to diagnose, we compared characteristics of women with confirmed versus presumably misdiagnosed bipolar disorder. METHOD: This cohort study was conducted from July 2005 to January 2010 in the outpatient clinic of the Emory Women's Mental Health Program, Atlanta, Georgia. Young adult women (mean age = 32 years) who were either pregnant or planning to conceive and who reported having previous clinical diagnoses of bipolar disorder completed 2 independent diagnostic assessments: the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) and an evaluation by a perinatal mood-disorder expert who was masked to the SCID findings...
February 2012: Journal of Clinical Psychiatry
D Jeffrey Newport, Shuang Ji, Qi Long, Bettina T Knight, Elizabeth B Zach, Elizabeth N Smith, Natalie J Morris, Zachary N Stowe
OBJECTIVE: To examine the association between severity of maternal depression and anxiety during pregnancy and the maternal use of medicinal agents and habit-forming substances. METHOD: Participants in a prospective study of prenatal DSM-IV depressive and anxiety disorders at the Emory Women's Mental Health Program who completed weekly documentation of prenatal drug exposure and ≥ 3 administrations of the Hamilton Depression Rating Scale (HDRS) or Hamilton Anxiety Rating Scale (HARS) were included...
February 2012: Journal of Clinical Psychiatry
Z P Johnson, R D Eady, S F Ahmad, S Agravat, T Morris, J Else, S M Lank, R W Wiseman, D H O'Connor, M C T Penedo, C P Larsen, L S Kean
Here we describe the Immunogenetic Management Software (IMS) system, a novel web-based application that permits multiplexed analysis of complex immunogenetic traits that are necessary for the accurate planning and execution of experiments involving large animal models, including nonhuman primates. IMS is capable of housing complex pedigree relationships, microsatellite-based MHC typing data, as well as MHC pyrosequencing expression analysis of class I alleles. It includes a novel, automated MHC haplotype naming algorithm and has accomplished an innovative visualization protocol that allows users to view multiple familial and MHC haplotype relationships through a single, interactive graphical interface...
April 2012: Immunogenetics
Alanna Amyre Morris, Liping Zhao, Yusuf Ahmed, Neli Stoyanova, Christine De Staercke, William Craig Hooper, Gary Gibbons, Rebecca Din-Dzietham, Arshed Quyyumi, Viola Vaccarino
OBJECTIVE: To test whether the association between depression and inflammation differs by race and sex. Depressive symptoms have been associated with higher levels of C-reactive protein (CRP). However, few studies have examined this association in samples including a significant number of African Americans, or examined whether the association differs by race and sex. METHODS: Depressive symptoms and CRP were assessed in 512 African American and white participants, age 30 to 65 years, as part of the community-based Morehouse and Emory Team up to Eliminate Health Disparities (META-Health) Study...
July 2011: Psychosomatic Medicine
Vinod H Thourani, Eric L Sarin, W Brent Keeling, Patrick D Kilgo, Robert A Guyton, Ameesh B Dara, John D Puskas, Edward P Chen, William A Cooper, J David Vega, Cullen D Morris, Omar M Lattouf
BACKGROUND: The objective of this study was to assess short-term and long-term outcomes after valve replacement with biologic or mechanical prostheses in patients with preoperative end-stage renal disease on chronic dialysis. METHODS: A retrospective review of patients with end-stage renal disease undergoing valve replacement from January 1996 through March 2008 at Emory Healthcare Hospitals was performed. Outcomes were compared using χ(2) tests and 2-sample t tests...
April 2011: Annals of Thoracic Surgery
William A Cooper, Vinod H Thourani, Robert A Guyton, Patrick Kilgo, Omar M Lattouf, Edward P Chen, Cullen D Morris, J David Vega, Thomas A Vassiliades, John D Puskas
BACKGROUND: Race has been shown to be an independent risk factor for operative mortality after coronary artery bypass grafting (CABG). This study sought to determine the extent to which race is a risk factor for adverse events, long-term mortality, and whether off-pump surgery (OPCAB) modifies that risk. METHODS AND RESULTS: The Society of Thoracic Surgeons Adult Cardiac Database at Emory Healthcare affiliated hospitals was queried for all primary isolated CABG records from 1997 to 2007...
September 15, 2009: Circulation
Michael E Halkos, Omar M Lattouf, John D Puskas, Patrick Kilgo, William A Cooper, Cullen D Morris, Robert A Guyton, Vinod H Thourani
BACKGROUND: The predictive role of hemoglobin A1c (HbA1c) on long-term outcomes after coronary artery bypass surgery has not been evaluated. METHODS: Preoperative HbA1c levels were obtained in 3,201 patients undergoing primary, elective coronary artery bypass surgery at Emory Healthcare Hospitals from January 2002 to December 2006 and entered prospectively into a computerized database. Long-term survival status was determined by cross-referencing patient records with the Social Security Death Index...
November 2008: Annals of Thoracic Surgery
D J Newport, P A Brennan, P Green, D Ilardi, T H Whitfield, N Morris, B T Knight, Z N Stowe
OBJECTIVE: Outcome investigations of prenatal maternal depression and psychotropic exposure rely extensively on maternal retrospective recall. This study compared postnatal recall to prospective documentation of illness and medication exposures. DESIGN: Prospective cohort and retrospective case-control studies. SETTING: Emory Women's Mental Health Program (prospective study) and Emory University Department of Psychology (retrospective study)...
May 2008: BJOG: An International Journal of Obstetrics and Gynaecology
César Gálvez-Hernández, Morris Emory Franklin, Oscar Villegas-Cabello, José Díaz-Elizondo, Jorge Manuel Treviño, Dulce Salazar-López
BACKGROUND: Laparoscopy is currently and progressively gaining acceptance for the management of colorectal disease. More bleeding and longer operating time were initially considered as contraindications to perform laparoscopic colon resections. Other obstacles were technical difficulties, the learning curve and the need for specialized instruments; however, improvements in surgical techniques and technological developments have allowed subtotal laparoscopic colectomy to be feasible. METHODS: This was a retrospective and descriptive study conducted from April 1992 to July 2006...
November 2007: Cirugia y Cirujanos
A M Grabowska, T M Morris, A J McKenzie, R Kumari, H Hamano, Y Emori, K Yoshinaga, S A Watson
BACKGROUND: Gastrin has a role in gastrointestinal (GI) malignancy. This study provides pre-clinical evaluation of a novel, orally-active gastrin/cholecystokinin-2 receptor (CCK-2R) antagonist, Z-360. METHODS: (125)I gastrin-17 (G17) displacement and G17-stimulated calcium assays were used in classical CCK-2R-transfected cell lines. Akt phosphorylation was assessed by Western blotting. Z-360 efficacy in vivo was evaluated in three human xenograft models, and microvessel density and apoptosis in these models were investigated by immunohistochemistry...
February 7, 2008: Regulatory Peptides
Kelly R Powell, H Elliott Albers
The Center for Behavioral Neuroscience was launched in the fall of 1999 with support from the National Science Foundation, the Georgia Research Alliance, and our eight participating institutions (Georgia State University, Emory University, Georgia Institute of Technology, Morehouse School of Medicine, Clark-Atlanta University, Spelman College, Morehouse College, Morris Brown College). The CBN provides the resources to foster innovative research in behavioral neuroscience, with a specific focus on the neurobiology of social behavior...
2006: Journal of Biomedical Discovery and Collaboration
Christine Liang, Andrea Morris, Sebastian Schlücker, Kyoko Imoto, Vera H Price, Emory Menefee, Stephen M Wincovitch, Ira W Levin, Deborah Tamura, Katrin R Strehle, Kenneth H Kraemer, John J DiGiovanna
We examined hair from 15 patients with trichothiodystrophy (TTD), a rare inherited disorder with brittle, cystine-deficient hair. They had a wide variety of phenotypes, from brittle hair only to severe intellectual impairment and developmental delay. Polarizing light microscopic examination showed alternating light and dark (tiger tail) bands under polarizing microscopy. Confocal microscopy captured structural features of breaks in intact TTD hairs. The autofluorescent appearance was regular and smooth in normal donors and markedly irregular in sections of TTD hairs possibly reflecting abnormalities in melanin distribution...
October 2006: Journal of Investigative Dermatology
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