keyword
MENU ▼
Read by QxMD icon Read
search

Douglas Murphy

keyword
https://www.readbyqxmd.com/read/29778659/sepsis-3-septic-shock-criteria-and-associated-mortality-among-infected-hospitalized-patients-assessed-by-a-rapid-response-team
#1
Shannon M Fernando, Peter M Reardon, Bram Rochwerg, Nathan I Shapiro, Donald M Yealy, Andrew J E Seely, Jeffrey J Perry, Douglas P Barnaby, Kyle Murphy, Peter Tanuseputro, Kwadwo Kyeremanteng
BACKGROUND: Rapid Response Teams (RRTs) respond to deteriorating hospitalized patients, and help determine subsequent management, including Intensive Care Unit (ICU) admission. In such patients with sepsis and septic shock, the Sepsis-3 clinical criteria have a potential role in detection, risk-stratification, and prognostication, though their accuracy in comparison to the Systemic Inflammatory Response Syndrome (SIRS)-based septic shock criteria are unknown. We sought to evaluate prognostic accuracy of the Sepsis-3 criteria for in-hospital mortality among infected hospitalized patients with acute deterioration...
May 17, 2018: Chest
https://www.readbyqxmd.com/read/29776658/ustekinumab-for-refractory-giant-cell-arteritis-a-prospective-52-week-trial
#2
Richard Conway, Lorraine O'Neill, Phil Gallagher, Geraldine M McCarthy, Conor C Murphy, Douglas J Veale, Ursula Fearon, Eamonn S Molloy
OBJECTIVES: Giant cell arteritis (GCA) is the most common form of systemic vasculitis. Glucocorticoids are an effective treatment but have significant adverse events and relapses are common. Interleukins 12 (IL-12) and 23 (IL-23) stimulate TH 1 and TH 17 responses and are implicated in the pathogenesis of GCA. The aim of this study was to evaluate the efficacy and safety of IL-12/23 blockade with ustekinumab in GCA. METHODS: We performed a prospective open label study of ustekinumab in patients with refractory GCA...
April 22, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29712568/discovery-and-preclinical-characterization-of-the-antagonist-anti-pd-l1-monoclonal-antibody-ly3300054
#3
Yiwen Li, Carmine Carpenito, George Wang, David Surguladze, Amelie Forest, Maria Malabunga, Mary Murphy, Yiwei Zhang, Andreas Sonyi, Darin Chin, Douglas Burtrum, Ivan Inigo, Anthony Pennello, Leyi Shen, Laurent Malherbe, Xinlei Chen, Gerald Hall, Jaafar N Haidar, Dale L Ludwig, Ruslan D Novosiadly, Michael Kalos
BACKGROUND: Modulation of the PD-1/PD-L1 axis through antagonist antibodies that block either receptor or ligand has been shown to reinvigorate the function of tumor-specific T cells and unleash potent anti-tumor immunity, leading to durable objective responses in a subset of patients across multiple tumor types. RESULTS: Here we describe the discovery and preclinical characterization of LY3300054, a fully human IgG1λ monoclonal antibody that binds to human PD-L1 with high affinity and inhibits interactions of PD-L1 with its two cognate receptors PD-1 and CD80...
April 30, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29710395/age-of-first-exposure-to-tackle-football-and-chronic-traumatic-encephalopathy
#4
Michael L Alosco, Jesse Mez, Yorghos Tripodis, Patrick T Kiernan, Bobak Abdolmohammadi, Lauren Murphy, Neil W Kowall, Thor D Stein, Bertrand Russell Huber, Lee E Goldstein, Robert C Cantu, Douglas I Katz, Christine E Chaisson, Brett Martin, Todd M Solomon, Michael D McClean, Daniel H Daneshvar, Christopher J Nowinski, Robert A Stern, Ann C McKee
OBJECTIVE: To examine the effect of age of first exposure to tackle football on CTE pathological severity and age of neurobehavioral symptom onset in tackle football players with neuropathologically-confirmed CTE. METHODS: The sample included 246 tackle football players who donated their brains for neuropathological examination. 211 were diagnosed with CTE (126/211 were without comorbid neurodegenerative diseases) and 35 were without CTE. Informant interviews ascertained age of first exposure and age of cognitive and behavioral/mood symptom onset...
April 30, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29666432/genetic-validation-of-bipolar-disorder-identified-by-automated-phenotyping-using-electronic-health-records
#5
Chia-Yen Chen, Phil H Lee, Victor M Castro, Jessica Minnier, Alexander W Charney, Eli A Stahl, Douglas M Ruderfer, Shawn N Murphy, Vivian Gainer, Tianxi Cai, Ian Jones, Carlos N Pato, Michele T Pato, Mikael Landén, Pamela Sklar, Roy H Perlis, Jordan W Smoller
Bipolar disorder (BD) is a heritable mood disorder characterized by episodes of mania and depression. Although genomewide association studies (GWAS) have successfully identified genetic loci contributing to BD risk, sample size has become a rate-limiting obstacle to genetic discovery. Electronic health records (EHRs) represent a vast but relatively untapped resource for high-throughput phenotyping. As part of the International Cohort Collection for Bipolar Disorder (ICCBD), we previously validated automated EHR-based phenotyping algorithms for BD against in-person diagnostic interviews (Castro et al...
April 18, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29661838/chronic-supplementation-with-a-mitochondrial-antioxidant-mitoq-improves-vascular-function-in-healthy-older-adults
#6
Matthew J Rossman, Jessica R Santos-Parker, Chelsea A C Steward, Nina Z Bispham, Lauren M Cuevas, Hannah L Rosenberg, Kayla A Woodward, Michel Chonchol, Rachel A Gioscia-Ryan, Michael P Murphy, Douglas R Seals
Excess reactive oxygen species production by mitochondria is a key mechanism of age-related vascular dysfunction. Our laboratory has shown that supplementation with the mitochondrial-targeted antioxidant MitoQ improves vascular endothelial function by reducing mitochondrial reactive oxygen species and ameliorates arterial stiffening in old mice, but the effects in humans are unknown. Here, we sought to translate our preclinical findings to humans and determine the safety and efficacy of MitoQ. Twenty healthy older adults (60-79 years) with impaired endothelial function (brachial artery flow-mediated dilation <6%) underwent 6 weeks of oral supplementation with MitoQ (20 mg/d) or placebo in a randomized, placebo-controlled, double-blind, crossover design study...
April 16, 2018: Hypertension
https://www.readbyqxmd.com/read/29606098/learning-from-errors-assessing-final-year-medical-students-reflection-on-safety-improvement-five-year-cohort-study
#7
Vicki Tully, Douglas Murphy, Evridiki Fioratou, Arun Chaudhuri, James Shaw, Peter Davey
BACKGROUND: Investigation of real incidents has been consistently identified by expert reviews and student surveys as a potentially valuable teaching resource for medical students. The aim of this study was to adapt a published method to measure resident doctors' reflection on quality improvement and evaluate this as an assessment tool for medical students. METHODS: The design is a cohort study. Medical students were prepared with a tutorial in team based learning format and an online Managing Incident Review course...
April 2, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29526098/structure-based-design-of-pyridone-aminal-eft508-targeting-dysregulated-translation-by-selective-mitogen-activated-protein-kinase-interacting-kinases-1-and-2-mnk1-2-inhibition
#8
Siegfried H Reich, Paul A Sprengeler, Gary G Chiang, James R Appleman, Joan Chen, Jeff Clarine, Boreth Eam, Justin T Ernst, Qing Han, Vikas K Goel, Edward Z R Han, Vera Huang, Ivy N J Hung, Adrianna Jemison, Katti A Jessen, Jolene Molter, Douglas Murphy, Melissa Neal, Gregory S Parker, Michael Shaghafi, Samuel Sperry, Jocelyn Staunton, Craig R Stumpf, Peggy A Thompson, Chinh Tran, Stephen E Webber, Christopher J Wegerski, Hong Zheng, Kevin R Webster
Dysregulated translation of mRNA plays a major role in tumorigenesis. Mitogen-activated protein kinase interacting kinases (MNK)1/2 are key regulators of mRNA translation integrating signals from oncogenic and immune signaling pathways through phosphorylation of eIF4E and other mRNA binding proteins. Modulation of these key effector proteins regulates mRNA, which controls tumor/stromal cell signaling. Compound 23 (eFT508), an exquisitely selective, potent dual MNK1/2 inhibitor, was designed to assess the potential for control of oncogene signaling at the level of mRNA translation...
April 26, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29521869/the-impact-of-the-helping-babies-survive-program-on-neonatal-outcomes-and-health-provider-skills-a-systematic-review
#9
Justine Dol, Marsha Campbell-Yeo, Gail Tomblin Murphy, Megan Aston, Douglas McMillan, Brianna Richardson
OBJECTIVE: The objective of this review was to evaluate the impact of the Helping Babies Survive program on neonatal outcomes and healthcare provider knowledge and skills. INTRODUCTION: The Helping Babies Survive program consists of three modules: Helping Babies Breathe, Essential Care for Every Baby, and Essential Care for Small Babies. It was developed to reduce preventable newborn deaths through skill-based learning using simulation, learning exercises, and peer-to-peer training of healthcare providers in low-resource areas...
March 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29482427/immunization-and-technology-among-newcomers-a-needs-assessment-survey-for-a-vaccine-tracking-app
#10
Michelle Paradis, Katherine M Atkinson, Charles Hui, David Ponka, Douglas G Manuel, Paula Day, Malia S Q Murphy, Ruth Rennicks White, Kumanan Wilson
OBJECTIVES: Newcomers experience unique challenges with respect to vaccination. These challenges are compounded by the need to navigate complex vaccination catch-up schedules upon arrival in their new home countries. Our group has pioneered the development of CANImmunize, a free, bilingual, pan-Canadian digital application designed to empower individuals to manage their vaccination records. To inform how a vaccine tracking app such as CANImmunize might be tailored to meet the unique needs of newcomers, this study sought to determine commonly spoken languages, technology use, and current methods of vaccine tracking among recent newcomers to Canada...
February 26, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29460029/outcome-of-adult-patients-with-x-linked-hypophosphatemia-caused-by-phex-gene-mutations
#11
Douglas Chesher, Michael Oddy, Ulpee Darbar, Parag Sayal, Adrian Casey, Aidan Ryan, Annalisa Sechi, Charlotte Simister, Aoife Waters, Yehani Wedatilake, Robin H Lachmann, Elaine Murphy
X-linked hypophosphatemia (XLH) is the most common monogenic disorder causing hypophosphatemia. This case-note review documents the clinical features and the complications of treatment in 59 adults (19 male, 40 female) with XLH. XLH is associated with a large number of private mutations; 37 different mutations in the PHEX gene were identified in this cohort, 14 of which have not been previously reported. Orthopaedic involvement requiring surgical intervention (osteotomy) was frequent. Joint replacement and decompressive laminectomy were observed in those older than 40 years...
February 19, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29417572/key-design-considerations-when-calculating-cost-savings-for-population-health-management-programs-in-an-observational-setting
#12
Shannon M E Murphy, Douglas E Hough, Martha L Sylvia, Linda J Dunbar, Kevin D Frick
OBJECTIVE: To illustrate the impact of key quasi-experimental design elements on cost savings measurement for population health management (PHM) programs. DATA SOURCES: Population health management program records and Medicaid claims and enrollment data from December 2011 through March 2016. STUDY DESIGN: The study uses a difference-in-difference design to compare changes in cost and utilization outcomes between program participants and propensity score-matched nonparticipants...
February 8, 2018: Health Services Research
https://www.readbyqxmd.com/read/29413544/thermal-antinociceptive-and-agitation-sedation-effects-after-intramuscular-administration-of-hydromorphone-hydrochloride-in-orange-winged-amazon-parrots-amazona-amazonica
#13
D Sanchez-Migallon Guzman, J Douglas, H Beaufrère, J Paul-Murphy
No abstract text is available yet for this article.
September 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29410099/repeat-robotic-endoscopic-mitral-valve-surgery-a-safe-and-effective-strategy
#14
Douglas A Murphy, Emmanuel Moss, Jeffrey Miller, Michael E Halkos
BACKGROUND: Mitral valve reoperation is necessary in a finite percent of patients. With growth in robotic mitral valve surgery, reoperative strategies need to be developed. A review of institutional mitral valve re-operations after a previous robotic approach was undertaken. METHODS: From January 2006 through April 2017, 1853 patients underwent an initial robotic mitral valve surgery by a dedicated robotic team. Fifty-four (2.9%) of these patients required mitral reoperation at our institution over this time period...
February 2, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29311302/fenofibrate-prevents-skeletal-muscle-loss-in-mice-with-lung-cancer
#15
Marcus D Goncalves, Seo-Kyoung Hwang, Chantal Pauli, Charles J Murphy, Zhe Cheng, Benjamin D Hopkins, David Wu, Ryan M Loughran, Brooke M Emerling, Guoan Zhang, Douglas T Fearon, Lewis C Cantley
The cancer anorexia cachexia syndrome is a systemic metabolic disorder characterized by the catabolism of stored nutrients in skeletal muscle and adipose tissue that is particularly prevalent in nonsmall cell lung cancer (NSCLC). Loss of skeletal muscle results in functional impairments and increased mortality. The aim of the present study was to characterize the changes in systemic metabolism in a genetically engineered mouse model of NSCLC. We show that a portion of these animals develop loss of skeletal muscle, loss of adipose tissue, and increased inflammatory markers mirroring the human cachexia syndrome...
January 23, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29290633/sam-caam-a-concept-for-acquiring-systematic-aircraft-measurements-to-characterize-aerosol-air-masses
#16
Ralph A Kahn, Tim A Berkoff, Charles Brock, Gao Chen, Richard A Ferrare, Steven Ghan, Thomas F Hansico, Dean A Hegg, J Vanderlei Martins, Cameron S McNaughton, Daniel M Murphy, John A Ogren, Joyce E Penner, Peter Pilewskie, John H Seinfeld, Douglas R Worsnop
A modest operational program of systematic aircraft measurements can resolve key satellite-aerosol-data-record limitations. Satellite observations provide frequent, global aerosol-amount maps, but offer only loose aerosol property constraints needed for climate and air quality applications. We define and illustrate the feasibility of flying an aircraft payload to measure key aerosol optical, microphysical, and chemical properties in situ . The flight program could characterize major aerosol air-mass types statistically, at a level-of-detail unobtainable from space...
October 2017: Bulletin of the American Meteorological Society
https://www.readbyqxmd.com/read/29204104/assessing-the-consultation-and-relational-empathy-care-measure-in-sexual-health-nurses-consultations
#17
Annemieke P Bikker, Bridie Fitzpatrick, Douglas Murphy, Lorraine Forster, Stewart W Mercer
Background: Increasingly healthcare policies emphasise the importance of person-centred, empathic care. Consequently, healthcare professionals are expected to demonstrate the 'human' aspects of care in training and in practice. The Consultation and Relational Empathy (CARE) Measure is a patient-rated measure of the interpersonal skills of healthcare practitioners. It has been widely validated for use by healthcare professionals in both primary and secondary care. This paper reports on the validity and reliability of the CARE Measure with sexual health nurses...
2017: BMC Nursing
https://www.readbyqxmd.com/read/29183182/cost-effectiveness-of-human-papilloma-virus-vaccination-in-low-and-middle-income-countries-a-systematic-review-of-literature
#18
Olugbenga Akindele Silas, Chad J Achenbach, Robert Leo Murphy, Lifang Hou, Solomon Atiene Sagay, Edmund Banwat, Adeyi A Adoga, Jonah Musa, Dustin Douglas French
Low and middle income countries (LMICs) bear more than 50% of the current cervical cancer burden over the last decade with linkages to lack of HPV vaccination, high levels of poverty, illiteracy and nonexistent or poor screening programs. Governments of LMICs need enough convincing evidence that HPV vaccination will be more cost-effective in reducing the scourge of cervical cancer. Area covered: A systematic review to identify suitable studies from MEDLINE(via PubMed), EMBASE and Electronic search through GOOGLE for original and review articles from 2007 to 2014 on cost-effectiveness of human papilloma virus vaccination of pre-adolescent girls in LMICs was conducted...
January 2018: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29149153/analysis-of-reporting-bias-in-vertebral-augmentation
#19
Douglas P Beall, Sean M Tutton, Kieran Murphy, Wayne Olan, Christopher Warner, Jack B Test
Osteoporotic vertebral compression fractures (OVCFs) are a significant cause of morbidity and mortality in the United States and worldwide, with estimates of 750,000 to 1.5 million occurring annually. As the elderly population continues to increase, the incidence of OVCFs will continue to rise, as will the morbidity and mortality associated with this condition. Vertebral augmentation (VA) was almost universally accepted as the appropriate treatment modality prior to 2 sham trials published in 2009 by the New England Journal of Medicine (NEJM)...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29146030/pain-in-birds-the-anatomical-and-physiological-basis
#20
REVIEW
Jamie M Douglas, David Sanchez-Migallon Guzman, Joanne R Paul-Murphy
This article reviews the current understanding of the anatomy and physiology of pain in birds, with consideration of some of its differences from mammalian pain. From transduction to transmission, modulation, projection, and perception, birds possess the neurologic components necessary to respond to painful stimuli and they likely perceive pain in a manner similar to mammals. This article also describes the current understating of opioid receptors, inflammatory mediators, and additional factors in the modulation of pain in avian species...
January 2018: Veterinary Clinics of North America. Exotic Animal Practice
keyword
keyword
59257
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"