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Douglas Murphy

Siegfried H Reich, Paul A Sprengeler, Gary G Chiang, Jim R Appleman, Joan Chen, Jeff Clarine, Boreth Eam, Justin T Ernst, Qing Han, Vikas K Goel, Edward Zr Han, Vera Huang, Ivy Nj Hung, Adrianna Jemison, Katti A Jessen, Jolene Molter, Douglas Murphy, Melissa Neal, Gregory S Parker, Michael Shaghafi, Samuel Sperry, Jocelyn Staunton, Craig R Stumpf, Peggy A Thompson, Chinh Tran, Stephen E Webber, Christopher J Wegerski, Hong Zheng, Kevin R Webster
Dysregulated translation of mRNA plays a major role in tumorigenesis. MNK1/2 kinases are key regulators of mRNA translation integrating signals from oncogenic and immune signaling pathways through phosphorylation of eIF4E and other mRNA binding proteins. Modulation of these key effector proteins regulates mRNA which control tumor/stromal cell signaling. 23 (eFT508), an exquisitely selective, potent dual MNK1/2 inhibitor, was designed to assess the potential for control of oncogene signaling at the level of mRNA translation...
March 10, 2018: Journal of Medicinal Chemistry
Justine Dol, Marsha Campbell-Yeo, Gail Tomblin Murphy, Megan Aston, Douglas McMillan, Brianna Richardson
OBJECTIVE: The objective of this review was to evaluate the impact of the Helping Babies Survive program on neonatal outcomes and healthcare provider knowledge and skills. INTRODUCTION: The Helping Babies Survive program consists of three modules: Helping Babies Breathe, Essential Care for Every Baby, and Essential Care for Small Babies. It was developed to reduce preventable newborn deaths through skill-based learning using simulation, learning exercises, and peer-to-peer training of healthcare providers in low-resource areas...
March 2018: JBI Database of Systematic Reviews and Implementation Reports
Michelle Paradis, Katherine M Atkinson, Charles Hui, David Ponka, Douglas G Manuel, Paula Day, Malia Sq Murphy, Ruth Rennicks White, Kumanan Wilson
OBJECTIVES: Newcomers experience unique challenges with respect to vaccination, challenges that are compounded by the need to navigate complex vaccination catch-up schedules upon arrival in Canada. Our group has pioneered the development of CANImmunize, a free, bilingual, pan-Canadian digital application designed to empower individuals to manage their vaccination records. To inform how a vaccine tracking app, such as CANImmunize might be tailored to meet the unique needs of newcomers, this study sought to determine commonly spoken languages, technology use, and current methods of vaccine tracking among recent newcomers to Canada...
February 26, 2018: Human Vaccines & Immunotherapeutics
Douglas Chesher, Michael Oddy, Ulpee Darbar, Parag Sayal, Adrian Casey, Aidan Ryan, Annalisa Sechi, Charlotte Simister, Aoife Waters, Yehani Wedatilake, Robin H Lachmann, Elaine Murphy
X-linked hypophosphatemia (XLH) is the most common monogenic disorder causing hypophosphatemia. This case-note review documents the clinical features and the complications of treatment in 59 adults (19 male, 40 female) with XLH. XLH is associated with a large number of private mutations; 37 different mutations in the PHEX gene were identified in this cohort, 14 of which have not been previously reported. Orthopaedic involvement requiring surgical intervention (osteotomy) was frequent. Joint replacement and decompressive laminectomy were observed in those older than 40 years...
February 19, 2018: Journal of Inherited Metabolic Disease
Shannon M E Murphy, Douglas E Hough, Martha L Sylvia, Linda J Dunbar, Kevin D Frick
OBJECTIVE: To illustrate the impact of key quasi-experimental design elements on cost savings measurement for population health management (PHM) programs. DATA SOURCES: Population health management program records and Medicaid claims and enrollment data from December 2011 through March 2016. STUDY DESIGN: The study uses a difference-in-difference design to compare changes in cost and utilization outcomes between program participants and propensity score-matched nonparticipants...
February 8, 2018: Health Services Research
D Sanchez-Migallon Guzman, J Douglas, H Beaufrère, J Paul-Murphy
No abstract text is available yet for this article.
September 2017: Veterinary Anaesthesia and Analgesia
Douglas A Murphy, Emmanuel Moss, Jeffrey Miller, Michael E Halkos
BACKGROUND: Mitral valve reoperation is necessary in a finite percent of patients. With growth in robotic mitral valve surgery, reoperative strategies need to be developed. A review of institutional mitral valve re-operations after a previous robotic approach was undertaken. METHODS: From January 2006 through April 2017, 1853 patients underwent an initial robotic mitral valve surgery by a dedicated robotic team. Fifty-four (2.9%) of these patients required mitral reoperation at our institution over this time period...
February 2, 2018: Annals of Thoracic Surgery
Marcus D Goncalves, Seo-Kyoung Hwang, Chantal Pauli, Charles J Murphy, Zhe Cheng, Benjamin D Hopkins, David Wu, Ryan M Loughran, Brooke M Emerling, Guoan Zhang, Douglas T Fearon, Lewis C Cantley
The cancer anorexia cachexia syndrome is a systemic metabolic disorder characterized by the catabolism of stored nutrients in skeletal muscle and adipose tissue that is particularly prevalent in nonsmall cell lung cancer (NSCLC). Loss of skeletal muscle results in functional impairments and increased mortality. The aim of the present study was to characterize the changes in systemic metabolism in a genetically engineered mouse model of NSCLC. We show that a portion of these animals develop loss of skeletal muscle, loss of adipose tissue, and increased inflammatory markers mirroring the human cachexia syndrome...
January 8, 2018: Proceedings of the National Academy of Sciences of the United States of America
Ralph A Kahn, Tim A Berkoff, Charles Brock, Gao Chen, Richard A Ferrare, Steven Ghan, Thomas F Hansico, Dean A Hegg, J Vanderlei Martins, Cameron S McNaughton, Daniel M Murphy, John A Ogren, Joyce E Penner, Peter Pilewskie, John H Seinfeld, Douglas R Worsnop
A modest operational program of systematic aircraft measurements can resolve key satellite-aerosol-data-record limitations. Satellite observations provide frequent, global aerosol-amount maps, but offer only loose aerosol property constraints needed for climate and air quality applications. We define and illustrate the feasibility of flying an aircraft payload to measure key aerosol optical, microphysical, and chemical properties in situ. The flight program could characterize major aerosol air-mass types statistically, at a level-of-detail unobtainable from space...
October 2017: Bulletin of the American Meteorological Society
Annemieke P Bikker, Bridie Fitzpatrick, Douglas Murphy, Lorraine Forster, Stewart W Mercer
Background: Increasingly healthcare policies emphasise the importance of person-centred, empathic care. Consequently, healthcare professionals are expected to demonstrate the 'human' aspects of care in training and in practice. The Consultation and Relational Empathy (CARE) Measure is a patient-rated measure of the interpersonal skills of healthcare practitioners. It has been widely validated for use by healthcare professionals in both primary and secondary care. This paper reports on the validity and reliability of the CARE Measure with sexual health nurses...
2017: BMC Nursing
Olugbenga Akindele Silas, Chad J Achenbach, Robert Leo Murphy, Lifang Hou, Solomon Atiene Sagay, Edmund Banwat, Adeyi A Adoga, Jonah Musa, Dustin Douglas French
Low and middle income countries (LMICs) bear more than 50% of the current cervical cancer burden over the last decade with linkages to lack of HPV vaccination, high levels of poverty, illiteracy and nonexistent or poor screening programs. Governments of LMICs need enough convincing evidence that HPV vaccination will be more cost-effective in reducing the scourge of cervical cancer. Area covered: A systematic review to identify suitable studies from MEDLINE(via PubMed), EMBASE and Electronic search through GOOGLE for original and review articles from 2007 to 2014 on cost-effectiveness of human papilloma virus vaccination of pre-adolescent girls in LMICs was conducted...
January 2018: Expert Review of Vaccines
Douglas P Beall, Sean M Tutton, Kieran Murphy, Wayne Olan, Christopher Warner, Jack B Test
Osteoporotic vertebral compression fractures (OVCFs) are a significant cause of morbidity and mortality in the United States and worldwide, with estimates of 750,000 to 1.5 million occurring annually. As the elderly population continues to increase, the incidence of OVCFs will continue to rise, as will the morbidity and mortality associated with this condition. Vertebral augmentation (VA) was almost universally accepted as the appropriate treatment modality prior to 2 sham trials published in 2009 by the New England Journal of Medicine (NEJM)...
November 2017: Pain Physician
Jamie M Douglas, David Sanchez-Migallon Guzman, Joanne R Paul-Murphy
This article reviews the current understanding of the anatomy and physiology of pain in birds, with consideration of some of its differences from mammalian pain. From transduction to transmission, modulation, projection, and perception, birds possess the neurologic components necessary to respond to painful stimuli and they likely perceive pain in a manner similar to mammals. This article also describes the current understating of opioid receptors, inflammatory mediators, and additional factors in the modulation of pain in avian species...
January 2018: Veterinary Clinics of North America. Exotic Animal Practice
Rachel A Gioscia-Ryan, Micah L Battson, Lauren M Cuevas, Jason S Eng, Michael P Murphy, Douglas R Seals
Aortic stiffening is a major independent risk factor for cardiovascular diseases, cognitive dysfunction and other chronic disorders of aging. Mitochondria-derived reactive oxygen species are a key source of arterial oxidative stress which may contribute to arterial stiffening by promoting adverse structural changes-including collagen overabundance and elastin degradation-and enhancing inflammation, but the potential for mitochondria-targeted therapeutic strategies to ameliorate aortic stiffening with primary aging is unknown...
October 26, 2017: Journal of Applied Physiology
Roozbeh Atri, J Sebastian Marquez, Douglas Murphy, Ashraf Gorgey, DingYu Fei, John Fox, William Lovegreen, Ou Bai
In recent years, active prosthetic legs have been developed and deployed commercially that help amputees to initiate gait with less effort and more symmetry in the pattern. However, the process of initial set up and tuning is highly time and cost consuming. It requires prosthetic experts to observe the gait and the feedback from amputees to manually tune the parameters subjectively. In this study, an electromyography (EMG)-based energy expenditure optimization method was presented to automatically tune the prosthetic limb...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Genevieve E Davis, Mark F Baumgartner, Julianne M Bonnell, Joel Bell, Catherine Berchok, Jacqueline Bort Thornton, Solange Brault, Gary Buchanan, Russell A Charif, Danielle Cholewiak, Christopher W Clark, Peter Corkeron, Julien Delarue, Kathleen Dudzinski, Leila Hatch, John Hildebrand, Lynne Hodge, Holger Klinck, Scott Kraus, Bruce Martin, David K Mellinger, Hilary Moors-Murphy, Sharon Nieukirk, Douglas P Nowacek, Susan Parks, Andrew J Read, Aaron N Rice, Denise Risch, Ana Širović, Melissa Soldevilla, Kate Stafford, Joy E Stanistreet, Erin Summers, Sean Todd, Ann Warde, Sofie M Van Parijs
Given new distribution patterns of the endangered North Atlantic right whale (NARW; Eubalaena glacialis) population in recent years, an improved understanding of spatio-temporal movements are imperative for the conservation of this species. While so far visual data have provided most information on NARW movements, passive acoustic monitoring (PAM) was used in this study in order to better capture year-round NARW presence. This project used PAM data from 2004 to 2014 collected by 19 organizations throughout the western North Atlantic Ocean...
October 18, 2017: Scientific Reports
Hamadi A Murphy, Eugene Warnick, Richard McGintee, Kristen Nicholson, Douglas A Hollern, Christie Stawicki, Daniel Tarazona, Gregory D Schroeder, Barrett I Woods, Mark F Kurd, Jeffrey A Rihn, Greg D Anderson, Christopher K Kepler, Alan S Hilibrand, Alexander R Vaccaro, Kris E Radcliff
STUDY DESIGN: Retrospective Review OBJECTIVE.: The purpose of this study is to determine the differential improvement of the various individual items of the ODI and to determine their relationship to other measures of HRQOL. SUMMARY OF BACKGROUND DATA: The oswestry disability index (ODI) is an easily scored, common, ten-item questionnaire about symptoms relevant to lumbar spine pathology. It is not clear if all of the items can be reliably applied to spine surgery...
October 12, 2017: Spine
Jingtao Guo, Edward J Grow, Chongil Yi, Hana Mlcochova, Geoffrey J Maher, Cecilia Lindskog, Patrick J Murphy, Candice L Wike, Douglas T Carrell, Anne Goriely, James M Hotaling, Bradley R Cairns
Human adult spermatogonial stem cells (hSSCs) must balance self-renewal and differentiation. To understand how this is achieved, we profiled DNA methylation and open chromatin (ATAC-seq) in SSEA4+ hSSCs, analyzed bulk and single-cell RNA transcriptomes (RNA-seq) in SSEA4+ hSSCs and differentiating c-KIT+ spermatogonia, and performed validation studies via immunofluorescence. First, DNA hypomethylation at embryonic developmental genes supports their epigenetic "poising" in hSSCs for future/embryonic expression, while core pluripotency genes (OCT4 and NANOG) were transcriptionally and epigenetically repressed...
October 5, 2017: Cell Stem Cell
Douglas J Murphy, David A Bruce
No abstract text is available yet for this article.
October 2017: Medical Education
Yongmei Liu, Lindsay M Reynolds, Jingzhong Ding, Li Hou, Kurt Lohman, Tracey Young, Wei Cui, Zhiqing Huang, Carole Grenier, Ma Wan, Hendrik G Stunnenberg, David Siscovick, Lifang Hou, Bruce M Psaty, Stephen S Rich, Jerome I Rotter, Joel D Kaufman, Gregory L Burke, Susan Murphy, David R Jacobs, Wendy Post, Ina Hoeschele, Douglas A Bell, David Herrington, John S Parks, Russell P Tracy, Charles E McCall, James H Stein
Little is known regarding the epigenetic basis of atherosclerosis. Here we present the CD14+ blood monocyte transcriptome and epigenome signatures associated with human atherosclerosis. The transcriptome signature includes transcription coactivator, ARID5B, which is known to form a chromatin derepressor complex with a histone H3K9Me2-specific demethylase and promote adipogenesis and smooth muscle development. ARID5B CpG (cg25953130) methylation is inversely associated with both ARID5B expression and atherosclerosis, consistent with this CpG residing in an ARID5B enhancer region, based on chromatin capture and histone marks data...
August 30, 2017: Nature Communications
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