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Douglas Murphy

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https://www.readbyqxmd.com/read/28316276/levosimendan-in-patients-with-left-ventricular-dysfunction-undergoing-cardiac-surgery
#1
Rajendra H Mehta, Jeffrey D Leimberger, Sean van Diepen, James Meza, Alice Wang, Rachael Jankowich, Robert W Harrison, Douglas Hay, Stephen Fremes, Andra Duncan, Edward G Soltesz, John Luber, Soon Park, Michael Argenziano, Edward Murphy, Randy Marcel, Dimitri Kalavrouziotis, Dave Nagpal, John Bozinovski, Wolfgang Toller, Matthias Heringlake, Shaun G Goodman, Jerrold H Levy, Robert A Harrington, Kevin J Anstrom, John H Alexander
Background Levosimendan is an inotropic agent that has been shown in small studies to prevent or treat the low cardiac output syndrome after cardiac surgery. Methods In a multicenter, randomized, placebo-controlled, phase 3 trial, we evaluated the efficacy and safety of levosimendan in patients with a left ventricular ejection fraction of 35% or less who were undergoing cardiac surgery with the use of cardiopulmonary bypass. Patients were randomly assigned to receive either intravenous levosimendan (at a dose of 0...
March 19, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28265006/characterization-of-the-anti-pd-1-antibody-regn2810-and-its-antitumor-activity-in-human-pd-1-knock-in-mice
#2
Elena Burova, Aynur Hermann, Janelle Waite, Terra Potocky, Venus Lai, Seongwon Hong, Matt Liu, Omaira Allbritton, Amy Woodruff, Qi Wu, Amanda D'Orvilliers, Elena Garnova, Ashique Rafique, William Poueymirou, Joel Martin, Tammy Huang, Dimitris Skokos, Joel Kantrowitz, Jon Popke, Markus Mohrs, Douglas MacDonald, Ella Ioffe, William Olson, Israel Lowy, Andrew Murphy, Gavin Thurston
The Programmed Death-1 (PD-1) receptor delivers inhibitory checkpoint signals to activated T cells upon binding to its ligands PD-L1 and PD-L2 expressed on antigen presenting cells and cancer cells, resulting in suppression of T cell effector function and tumor immune evasion. Clinical antibodies blocking the interaction between PD-1 and PD-L1 restore the cytotoxic function of tumor antigen-specific T cells, yielding durable objective responses in multiple cancers. This report describes the preclinical characterization of REGN2810, a fully human hinge-stabilized IgG4 (S228P) high-affinity anti-PD-1 antibody that potently blocks PD-1 interactions with PD-L1 and PD-L2...
March 6, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28129341/photoinactivation-of-photosystem-ii-in-prochlorococcus-and-synechococcus
#3
Cole D Murphy, Mitchell S Roodvoets, Emily J Austen, Allison Dolan, Audrey Barnett, Douglas A Campbell
The marine picocyanobacteria Synechococcus and Prochlorococcus numerically dominate open ocean phytoplankton. Although evolutionarily related they are ecologically distinct, with different strategies to harvest, manage and exploit light. We grew representative strains of Synechococcus and Prochlorococcus and tracked their susceptibility to photoinactivation of Photosystem II under a range of light levels. As expected blue light provoked more rapid photoinactivation than did an equivalent level of red light...
2017: PloS One
https://www.readbyqxmd.com/read/28114187/nevirapine-pharmacokinetics-and-safety-in-neonates-receiving-combination-antiretroviral-therapy-for-prevention-of-vertical-hiv-transmission
#4
Elaine Lau, Jason Brophy, Lindy Samson, Fatima Kakkar, Douglas Campbell, Mark H Yudin, Kellie Murphy, Winnie Seto, David Colantonio, Stanley E Read, Ari Bitnun
BACKGROUND: Nevirapine (NVP)-based combination antiretroviral therapy (cART) is routinely prescribed to infants deemed at high risk of vertical HIV infection in our centers. We evaluated NVP pharmacokinetics and safety of this regimen. METHODS: Neonates were recruited prospectively between September 2012 and April 2015 or enrolled retrospectively if treated similarly prior to prospective study initiation. NVP was dosed at 150 mg/m daily for 14 days, then twice daily for 14 days...
January 20, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28112924/discovery-of-pyrrolidine-containing-gpr40-agonists-stereochemistry-effects-a-change-in-binding-mode
#5
Elizabeth A Jurica, Ximao Wu, Kristin N Williams, Andres S Hernandez, David S Nirschl, Richard A Rampulla, Arvind Mathur, Min Zhou, Gary Cao, Chunshan Xie, Biji Jacob, Hong Cai, Tao Wang, Brian J Murphy, Heng Liu, Carrie Xu, Lori K Kunselman, Michael B Hicks, Qin Sun, Dora M Schnur, Doree F Sitkoff, Elizabeth A Dierks, Atsu Apedo, Douglas B Moore, Kimberly A Foster, Mary Ellen Cvijic, Reshma Panemangalore, Neil A Flynn, Brad D Maxwell, Yang Hong, Yuan Tian, Jason J Wilkes, Bradley A Zinker, Jean M Whaley, Joel C Barrish, Jeffrey A Robl, William R Ewing, Bruce A Ellsworth
A novel series of pyrrolidine-containing GPR40 agonists is described as a potential treatment for type 2 diabetes. The initial pyrrolidine hit was modified by moving the position of the carboxylic acid, a key pharmacophore for GPR40. Addition of a 4-cis-CF3 to the pyrrolidine improves the human GPR40 binding Ki and agonist efficacy. After further optimization, the discovery of a minor enantiomeric impurity with agonist activity led to the finding that enantiomers (R,R)-68 and (S,S)-68 have differential effects on the radioligand used for the binding assay, with (R,R)-68 potentiating the radioligand and (S,S)-68 displacing the radioligand...
February 9, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28078762/competence-in-the-use-of-supraglottic-airways-by-australian-surf-lifesavers-for-cardiac-arrest-ventilation-in-a-manikin
#6
Lachlan Holbery-Morgan, Cara Angel, Michelle Murphy, James Carew, Finn Douglas, Robert Murphy, Natalie Hood, Andrew Rechtman, Christopher Scarff, Nicholas Simpson, Andrew Stewardson, Daniel Steinfort, Sam Radford, Ned Douglas, Douglas Johnson
OBJECTIVES: Lifesavers in Australia are taught to use pocket mask (PM) rescue breathing and bag valve mask (BVM) ventilation, despite evidence that first responders might struggle with these devices. Novices have successfully used the Laryngeal Mask Airway (LMA) Supreme and iGel devices previously, but there has been no previous comparison of the ability to train lifesavers to use the supraglottic airways compared to standard techniques for cardiac arrest ventilation. METHODS: The study is a prospective educational intervention whereby 113 lifesavers were trained to use the LMA and iGel supraglottic airways...
February 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28059943/efficacy-safety-and-outcomes-of-endoscopic-retrograde-cholangiopancreatography-with-per-oral-pancreatoscopy-a-multicenter-experience
#7
Sheeva K Parbhu, Ali A Siddiqui, Megan Murphy, Arish Noor, Linda J Taylor, Alyssa Mills, Douglas G Adler
INTRODUCTION: Per-oral pancreatoscopy can be used for both evaluation and treatment of pancreatic duct stones during endoscopic retrograde cholangiopancreatography, evaluating and treating pancreatic duct strictures of indeterminate etiology, and visual inspection and direct biopsy of pancreatic duct mucosa for diagnosis of intraductal papillary mucinous neoplasm (IPMN). We aim to describe the efficacy, safety, and outcomes of pancreatoscopy in a large, multicenter series of patients...
January 5, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28033512/the-beliefs-about-paranoia-scale-confirmatory-factor-analysis-and-tests-of-a-metacognitive-model-of-paranoia-in-a-clinical-sample
#8
Elizabeth K Murphy, Sarah Tully, Melissa Pyle, Andrew I Gumley, David Kingdon, Matthias Schwannauer, Douglas Turkington, Anthony P Morrison
This study aimed to confirm the factor structure of the Beliefs about Paranoia Scale (BaPS), a self-report measure to assess metacognitive beliefs about paranoia, and to test hypotheses of a metacognitive model. We hypothesised that positive and negative beliefs about paranoia would be associated with severity of suspiciousness, and that the co-occurrence of positive and negative beliefs would be associated with increased suspiciousness. A total of 335 patients meeting criteria for a schizophrenia spectrum disorder completed the BaPS, the Positive and Negative Syndromes Scale (PANSS), and the Psychotic Symptom Rating Scales (PSYRATS)...
November 12, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28002377/own-the-bone-a-system-based-intervention-improves-osteoporosis-care-after-fragility-fractures
#9
Andrew D Bunta, Beatrice J Edwards, William B Macaulay, Kyle J Jeray, Laura L Tosi, Clifford B Jones, Debra L Sietsema, John D Kaufman, Sarah A Murphy, Juhee Song, James A Goulet, Gary E Friedlaender, Marc F Swiontkowski, Douglas R Dirschl
BACKGROUND: The goal of this study was to evaluate the effectiveness of the American Orthopaedic Association's Own the Bone secondary fracture prevention program in the United States. METHODS: The objective of this quality improvement cohort study was dissemination of Own the Bone and implementation of secondary prevention (osteoporosis pharmacologic and bone mineral density [BMD] test recommendations). The main outcome measures were the number of sites implementing Own the Bone and implementation of secondary prevention, i...
December 21, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27935972/distinct-epigenetic-effects-of-tobacco-smoking-in-whole-blood-and-among-leukocyte-subtypes
#10
Dan Su, Xuting Wang, Michelle R Campbell, Devin K Porter, Gary S Pittman, Brian D Bennett, Ma Wan, Neal A Englert, Christopher L Crowl, Ryan N Gimple, Kelly N Adamski, Zhiqing Huang, Susan K Murphy, Douglas A Bell
Tobacco smoke exposure dramatically alters DNA methylation in blood cells and may mediate smoking-associated complex diseases through effects on immune cell function. However, knowledge of smoking effects in specific leukocyte subtypes is limited. To better characterize smoking-associated methylation changes in whole blood and leukocyte subtypes, we used Illumina 450K arrays and Reduced Representation Bisulfite Sequencing (RRBS) to assess genome-wide DNA methylation. Differential methylation analysis in whole blood DNA from 172 smokers and 81 nonsmokers revealed 738 CpGs, including 616 previously unreported CpGs, genome-wide significantly associated with current smoking (p <1...
2016: PloS One
https://www.readbyqxmd.com/read/27883144/robust-synthesis-of-f-bodipys
#11
Michael Helmut Reynolds Beh, Katherine Isabelle Biehn Douglas, Kelsey Taylor Elver House, Alexandra Celeste Murphy, Jackson Scott Testemale Sinclair, Alison Thompson
A protocol is established for the high-yielding synthesis of F-BODIPYs involving non-anhydrous reagents and not requiring precautions to exclude moisture. This simple and robust strategy simply requires a second addition of NEt3 and BF3·OEt2, midway through the reaction period. The ratio and amounts of NEt3 and BF3·OEt2 used in each aliquot are critical to success (6 : 9 for each aliquot). The protocol can be completed using bench-dry apparatus, without need to achieve and maintain anhydrous conditions or solvents...
December 28, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27835640/mass-spectrometry-based-metabolomics-comparison-of-liver-grafts-from-donors-after-circulatory-death-dcd-and-donors-after-brain-death-dbd-used-in-human-orthotopic-liver-transplantation
#12
Olga Hrydziuszko, M Thamara P R Perera, Richard Laing, Jennifer Kirwan, Michael A Silva, Douglas A Richards, Nick Murphy, Darius F Mirza, Mark R Viant
Use of marginal liver grafts, especially those from donors after circulatory death (DCD), has been considered as a solution to organ shortage. Inferior outcomes have been attributed to donor warm ischaemic damage in these DCD organs. Here we sought to profile the metabolic mechanisms underpinning donor warm ischaemia. Non-targeted Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry metabolomics was applied to biopsies of liver grafts from donors after brain death (DBD; n = 27) and DCD (n = 10), both during static cold storage (T1) as well as post-reperfusion (T2)...
2016: PloS One
https://www.readbyqxmd.com/read/27790103/a-voxel-based-morphometry-study-reveals-local-brain-structural-alterations-associated-with-ambient-fine-particles-in-older-women
#13
Ramon Casanova, Xinhui Wang, Jeanette Reyes, Yasuyuki Akita, Marc L Serre, William Vizuete, Helena C Chui, Ira Driscoll, Susan M Resnick, Mark A Espeland, Jiu-Chiuan Chen
Objective: Exposure to ambient fine particulate matter (PM2.5: PM with aerodynamic diameters < 2.5 μm) has been linked with cognitive deficits in older adults. Using fine-grained voxel-wise analyses, we examined whether PM2.5 exposure also affects brain structure. Methods: Brain MRI data were obtained from 1365 women (aged 71-89) in the Women's Health Initiative Memory Study and local brain volumes were estimated using RAVENS (regional analysis of volumes in normalized space). Based on geocoded residential locations and air monitoring data from the U...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27662478/minimally-invasive-mitral-valve-surgery-iii-training-and-robotic-assisted-approaches
#14
Eric J Lehr, T Sloane Guy, Robert L Smith, Eugene A Grossi, Richard J Shemin, Evelio Rodriguez, Gorav Ailawadi, Arvind K Agnihotri, Trevor M Fayers, W Clark Hargrove, Brian W Hummel, Junaid H Khan, S Chris Malaisrie, John R Mehall, Douglas A Murphy, William H Ryan, Arash Salemi, Romualdo J Segurola, J Michael Smith, J Alan Wolfe, Paul W Weldner, Glenn R Barnhart, Scott M Goldman, Clifton T P Lewis
Minimally invasive mitral valve operations are increasingly common in the United States, but robotic-assisted approaches have not been widely adopted for a variety of reasons. This expert opinion reviews the state of the art and defines best practices, training, and techniques for developing a successful robotics program.
July 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/27639727/arctic-micromonas-uses-protein-pools-and-non-photochemical-quenching-to-cope-with-temperature-restrictions-on-photosystem-ii-protein-turnover
#15
Guangyan Ni, Gabrielle Zimbalatti, Cole D Murphy, Audrey B Barnett, Christopher M Arsenault, Gang Li, Amanda M Cockshutt, Douglas A Campbell
Micromonas strains of small prasinophyte green algae are found throughout the world's oceans, exploiting widely different niches. We grew arctic and temperate strains of Micromonas and compared their susceptibilities to photoinactivation of Photosystem II, their counteracting Photosystem II repair capacities, their Photosystem II content, and their induction and relaxation of non-photochemical quenching. In the arctic strain Micromonas NCMA 2099, the cellular content of active Photosystem II represents only about 50 % of total Photosystem II protein, as a slow rate constant for clearance of PsbA protein limits instantaneous repair...
February 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/27633740/dissociation-between-short-term-unloading-and-resistance-training-effects-on-skeletal-muscle-na-k-atpase-muscle-function-and-fatigue-in-humans
#16
Ben D Perry, Victoria L Wyckelsma, Robyn M Murphy, Collene H Steward, Mitchell Anderson, Itamar Levinger, Aaron C Petersen, Michael J McKenna
Physical training increases skeletal muscle Na(+),K(+)-ATPase content (NKA) and improves exercise performance, but the effects of inactivity per se on NKA content and isoform abundance in human muscle are unknown. We investigated the effects of 23-day unilateral lower limb suspension (ULLS) and subsequent 4-wk resistance training (RT) on muscle function and NKA in 6 healthy adults, measuring quadriceps muscle peak torque; fatigue and venous [K(+)] during intense one-legged cycling exercise; and skeletal muscle NKA content ([(3)H]ouabain binding) and NKA isoform abundances (immunoblotting) in muscle homogenates (α1-3, β1-2) and in single fibers (α1-3, β1)...
November 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27561177/comparison-of-endoscopic-robotic-versus-sternotomy-approach-for-the-resection-of-left-atrial-tumors
#17
Emmanuel Moss, Michael E Halkos, Jeffrey S Miller, Douglas A Murphy
OBJECTIVE: Primary cardiac tumors most commonly occur in the left atrium. The aim of this study was to compare outcomes among patients undergoing isolated left atrial tumor resection via sternotomy or robotic approach. METHODS: From 2003 to 2013, 69 patients underwent isolated left atrial tumor resection at 3 affiliated hospitals with either a sternotomy (n = 39) or robotic approach (n = 30). A retrospective review of prospectively collected data was performed, and outcomes were compared between the sternotomy and robotic groups...
July 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/27544290/prevention-of-unilateral-pulmonary-edema-complicating-robotic-mitral-valve-operations
#18
Emmanuel Moss, Michael E Halkos, Jose N Binongo, Douglas A Murphy
BACKGROUND: Unilateral pulmonary edema (UPE) has been reported after mitral operations performed through the right side of the chest. The clinical presentation is compatible with an ischemia-reperfusion injury. This report describes modifications to robotic mitral valve operations that were designed to reduce UPE. METHODS: We reviewed 15 patients with UPE after robotic mitral valve operations from 2006 through 2012. Technique modifications to reduce right lung ischemia were used from 2013 through June 2015...
January 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27539377/cognitive-reserve-as-a-modifier-of-clinical-expression-in-chronic-traumatic-encephalopathy-a-preliminary-examination
#19
Michael L Alosco, Jesse Mez, Neil W Kowall, Thor D Stein, Lee E Goldstein, Robert C Cantu, Douglas I Katz, Todd M Solomon, Patrick T Kiernan, Lauren Murphy, Bobak Abdolmohammadi, Daniel Daneshvar, Philip H Montenigro, Christopher J Nowinski, Robert A Stern, Ann C McKee
This study conducted a preliminary examination on cognitive reserve (CR) as a modifier of symptom expression in subjects with autopsy-confirmed chronic traumatic encephalopathy (CTE). The sample included 25 former professional football players neuropathologically diagnosed with CTE stage III or IV. Next of kin interviews ascertained age at cognitive and behavioral/mood symptom onset and demographic/athletic characteristics. Years of education and occupational attainment defined CR. High occupational achievement predicted later age at cognitive (p=0...
2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27519275/neuroprosthetics-in-amputee-and-brain-injury-rehabilitation
#20
REVIEW
Blessen C Eapen, Douglas P Murphy, David X Cifu
The goals of rehabilitation medicine programs are to promote health, restore functional impairments and improve quality of life. The field of neuroprosthetics has evolved over the last decade given an improved understanding of neuroscience and the incorporation of advanced biotechnology and neuroengineering in the rehabilitation setting to develop adaptable applications to help facilitate recovery for individuals with amputations and brain injury. These applications may include a simple cognitive prosthetics aid for impaired memory in brain-injured individuals to myoelectric prosthetics arms with artificial proprioceptive feedback for those with upper extremity amputations...
January 2017: Experimental Neurology
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