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JOURNAL ARTICLE
Abel A Pavía-López, José A Magaña-Serrano, José A Cigarroa-López, Adolfo Chávez-Mendoza, José L Mayorga-Butrón, Diego Araiza-Garaygordobil, Juan B Ivey-Miranda, Gustavo F Méndez-Machado, Héctor González-Godínez, Luisa F Aguilera-Mora, Antonio Jordán-Ríos, Luis Olmos-Domínguez, Marcos J Olalde-Román, Emma M Miranda-Malpica, Zuilma Vázquez-Ortiz, Jorge Rayo-Chávez, Alexandra A Mendoza, Manlio F Márquez-Murillo, Sergio A Chávez-Leal, Amada Álvarez-San Gabriel, Marissa A Silva-García, Alex D Pacheco-Bouthiller, Jorge A Aldrete-Velazco, Carlos A Guizar-Sánchez, Efraín Gaxiola-López, Arturo Guerra-López, Lourdes Figueiras-Graillet, Gustavo Sánchez-Miranda, Genaro H Mendoza-Zavala, Moisés Aceves-García, Adolfo Chávez-Negrete, Marisol Arroyo-Hernández, Bertha B Montaño-Velázquez, Luis F Romero-Moreno, María M Baquero-Hoyos, Liliana Velasco-Hidalgo, Ana L Rodríguez-Lozano, Nancy E Aguilar-Gómez, Mario Rodríguez-Vega, Jorge E Cossío-Aranda
Chronic heart failure continues to be one of the main causes of impairment in the functioning and quality of life of people who suffer from it, as well as one of the main causes of mortality in our country and around the world. Mexico has a high prevalence of risk factors for developing heart failure, such as high blood pressure, diabetes, and obesity, which makes it essential to have an evidence-based document that provides recommendations to health professionals involved in the diagnosis and treatment of these patients...
2024: Archivos de Cardiología de México
#2
JOURNAL ARTICLE
Bernard Douglas Maybury, Lisa Jane James, Neil Phillips, Indrani Venkatadasari, Iman Qureshi, James William Elliot Riley, Georgina Talbot, Shivir Moosai, Hannah Victoria Giles, Nicola Chadderton, James Dowds, Pallav Rakesh, Henry Crosland, Aidan Haslam, Sarah Lane, Monica Vega Gonzalez, David Davies, George Cherian, Amir Shenouda, Praveen Kumar Kaudlay Sathyanarayana, Jane Starczynski, Zbigniew Rudzki, Sridhar Chaganti
A reciprocal t(3;8) BCL6::MYC fusion is common in large B cell lymphoma (LBCL) with MYC and BCL6 disruption. These pseudo-double hit cases are not adverse, whereas t(3;8) negative MYC/BCL6 lymphoma has an inferior prognosis relative to other MYC-rearranged LBCL.
April 22, 2024: Blood
#3
JOURNAL ARTICLE
Ricardo Dzul-Caamal, Armando Vega-López, Jaime Rendón-von Osten
Under laboratory conditions, the toxicological effects of pesticides tend to be less variable and realistic than under field conditions, limiting their usefulness in environmental risk assessment. In the current study, the earthworm Eisenia fetida was selected as a bioindicator for assessing glyphosate toxic effects in two different trials to solve this dilemma. In Trial 1, the worms were exposed for 7 and 14 days to concentrations of a commercial glyphosate formulation (1 to 500 mg a.i. kg-1 ) currently used in the field...
April 22, 2024: Environmental Science and Pollution Research International
#4
JOURNAL ARTICLE
Silvia Fenix-Caballero, Adrián Sanchez-Vegas, Emilio Jesús Alegre Del-Rey, David Epstein, Leticia Garcia-Mochon, Antonio Olry de Labry Lima
INTRODUCTION: Abemaciclib is an oral inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). Data from the clinical trial monarchE (2023) showed improved survival from invasive disease. The aim of the present article was to conduct an economic assessment of adjuvant treatment with abemaciclib in women with luminal, HER2- and node-positive breast cancer. METHODS: A Markov model was constructed with four mutually exclusive health states (disease-free, local recurrence, distal recurrence and death)...
April 22, 2024: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
#5
JOURNAL ARTICLE
Haritha Cheraparambil, Miquel Vega-Paredes, Christina Scheu, Claudia Weidenthaler
Perovskites have attracted tremendous attention as potential catalysts for the oxygen evolution reaction (OER). It is well-known that the introduction of Fe into rare earth perovskites such as LaNiO3 enhances the intrinsic OER activity. Despite numerous studies on structure-property relationships, the origin of the activity and the nature of the active species are still elusive and unclear. In this work, we study a series of LaNi x Fe1- x O3 perovskites using in situ electrochemical surface-enhanced Raman spectroscopy and electron energy loss spectroscopy to decipher the surface evolution and formation of active species during OER...
April 22, 2024: ACS Applied Materials & Interfaces
#6
Maria Oorloff, Adam Hruby, Maxim Averbukh, Athena Alcala, Naibedya Dutta, Toni Castro Torres, Darius Moaddeli, Matthew Vega, Juri Kim, Andrew Bong, Aeowynn J Coakley, Daniel Hicks, Jing Wang, Tiffany Wang, Sally Hoang, Kevin M Tharp, Gilberto Garcia, Ryo Higuchi-Sanabria
Mechanical stress is a measure of internal resistance exhibited by a body or material when external forces, such as compression, tension, bending, etc. are applied. The study of mechanical stress on health and aging is a continuously growing field, as major changes to the extracellular matrix and cell-to-cell adhesions can result in dramatic changes to tissue stiffness during aging and diseased conditions. For example, during normal aging, many tissues including the ovaries, skin, blood vessels, and heart exhibit increased stiffness, which can result in a significant reduction in function of that organ...
April 12, 2024: bioRxiv
#7
Maureen Ascona, Ethan Kim Tieu, Erick Gonzalez-Vega, Daniel J Liebl, Roberta Brambilla
UNLABELLED: Traumatic spinal cord injury (SCI) is a devastating condition that impacts over 300,000 individuals in the US alone. Depending on the severity of the injury, SCI can lead to varying degrees of sensorimotor deficits and paralysis. Despite advances in our understanding of the underlying pathological mechanisms of SCI and the identification of promising molecular targets for repair and functional restoration, few therapies have made it into clinical use. To improve the success rate of clinical translation, more robust, sensitive, and reproducible means of functional assessment are required...
April 12, 2024: bioRxiv
#8
Chioma M Odo, Luis A Vega, Piyali Mukherjee, Sruti DebRoy, Anthony R Flores, Samuel A Shelburne
The major gram-positive pathogen group A Streptococcus (GAS) is a model organism for studying microbial epidemics as it causes waves of infections. Since 1980, several GAS epidemics have been ascribed to the emergence of clones producing increased amounts of key virulence factors such as streptolysin O (SLO). Herein, we sought to identify mechanisms underlying our recently identified temporal clonal emergence amongst emm4 GAS, given that emergent strains did not produce augmented levels of virulence factors relative to historic isolates...
April 10, 2024: bioRxiv
#9
JOURNAL ARTICLE
Jahir A Batista-Andrade, Claire Welty, Diego Iglesias Vega, Anna McClain, Lee Blaney
We investigated the fluorescent dissolved organic matter (FDOM) composition in two watersheds with variable land cover and wastewater infrastructure, including sanitary sewers and septic systems. A four-component parallel factor analysis model was constructed from 295 excitation-emission matrices recorded for stream samples to examine relationships between FDOM and geospatial parameters. The contributions of humic acid- and fulvic acid-like fluorescence components (e.g., C1, C2, C3) were fairly consistent across a 12 month period for the 27 sampling sites...
April 21, 2024: Environmental Science & Technology
#10
JOURNAL ARTICLE
Cristina Garcés-Visier, Paloma Conejero-Gonzalez, Maitane Andión-Catalán, Alberto Martín-Vega, Diego Muñoz-Hernández, Manuel Leónidas Espinoza-Vega, Ana Lourdes Luis-Huertas, José Lorenzo Alonso-Calderón
INTRODUCTION: Survival in paediatric patients with Hodgkin lymphoma (HL) has increased over the last decades. However, these patients are at increased risk of developing late thyroid sequelae due to the treatment with irradiation and alkylating agents. METHODS: We conducted an observational and retrospective study in patients with a diagnosis of HL between 2007 and 2022, in a hospital that is a paediatric oncology reference centre, through the review of electronic health records...
April 20, 2024: Anales de pediatría
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JOURNAL ARTICLE
Jeiczon Jaimes-Dueñez, Marisol Tique-Oviedo, Laura Arias-Vega, Edinson Castiblanco-Diaz, Leslie Rivero-Rodriguez, Laura Marin-Cossio, Agustín Gongora-Orjuela, Angela Jimenez-Leaño
Anaplasmosis and babesiosis are globally distributed arthropod-borne diseases known for causing substantial economic losses due to their high morbidity and mortality rates. This study aims to assess the frequency and epidemiological features associated with the infection of Anaplasma marginale, Babesia bigemina, and Babesia bovis in three Creole cattle breeds (Chino Santandereano (Chino), Casanareño (CAS), and Sanmartinero (SM)) in northeastern Colombia. Between June 2019 and March 2020, a total of 252 Creole cattle were sampled, with Chino, CAS, and SM accounting for 42...
May 2024: Veterinary Parasitology (Amsterdam)
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JOURNAL ARTICLE
Diego Moreno-Blanco, Erik Alonso, Ancor Sanz-García, Elisabete Aramendi, Raúl López-Izquierdo, Rubén Pérez García, Carlos Del Pozo Vegas, Francisco Martín-Rodríguez
BACKGROUND: This study aimed to evaluate three prehospital early warning scores (EWSs): RTS, MGAP and MREMS, to predict short-term mortality in acute life-threatening trauma and injury/illness by comparing United States (US) and Spanish cohorts. METHODS: A total of 8854 patients, 8598/256 survivors/nonsurvivors, comprised the unified cohort. Datasets were randomly divided into training and test sets. Training sets were used to analyze the discriminative power of the scores in terms of the area under the curve (AUC), and the score performance was assessed in the test set in terms of sensitivity (SE), specificity (SP), accuracy (ACC) and balanced accuracy (BAC)...
April 19, 2024: Clinical Medicine: Journal of the Royal College of Physicians of London
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JOURNAL ARTICLE
Laura Álvarez-Álvarez, María Rubín-García, Facundo Vitelli-Storelli, Silvia García, Cristina Bouzas, Miguel Ángel Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Mireia Malcampo, J Alfredo Martínez, Ángel M Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J Tinahones, José Lapetra, Lluís Serra-Majem, Aurora Bueno-Cavanillas, Camino García Fernández, Xavier Pintó, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Ana García-Arellano, María Ángeles Martínez, José V Sorlí, María Dolores Zomeño, Antonio García-Rios, Sandra González-Palacios, Margalida Monserrat-Mesquida, Itziar Abete, Antoni Colom Fernández, Rosa Casas, Naomi Cano Ibañez, Lucía Ugarriza, M Rosa Bernal-López, Maira Bes-Rastrollo, Indira Paz-Graniel, Eva M Asensio, Montse Fitó, Antonio P Arenas Larriva, Alejandro Oncina-Cánovas, Zenaida Vázquez, María Fernández de la Puente, Alejandra Pérez-Vega, Josep A Tur, Vicente Martín-Sánchez
OBJECTIVE: To estimate the environmental impact of a dietary intervention based on an energy-reduced Mediterranean diet (MedDiet) after one year of follow-up. METHODS: Baseline and 1-year follow-up data were used for 5800 participants aged 55-75 years with metabolic syndrome in the PREDIMED-Plus study. Food intake was estimated through a validated semiquantitative food consumption frequency questionnaire, and adherence to the MedDiet was estimated through the Diet Score...
April 18, 2024: Science of the Total Environment
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JOURNAL ARTICLE
Miriam Reyes-Ortiz, Andrés Lira-Noriega, Luis Osorio-Olvera, Isolda Luna-Vega, Guadalupe Williams-Linera
PREMISE: Functional traits reflect species' responses to environmental variation and the breadth of their ecological niches. Fagus grandifolia and Oreomunnea mexicana have restricted distribution in upper montane cloud forests (1700-2000 m a.s.l.) in Mexico. These species were introduced into plantings at lower elevations (1200-1600 m a.s.l.) that have climates predicted for montane forests in 2050 and 2070. The aim was to relate morphological leaf traits to the ecological niche structure of each species...
April 19, 2024: American Journal of Botany
#15
JOURNAL ARTICLE
Edinsson Muñoz-Vega, Marcel Horovitz, Lisa Dönges, Thomas Schiedek, Stephan Schulz, Christoph Schüth
Sorption of hydrophobic organic contaminants onto thermally altered carbonaceous materials (TACM) constitutes a widely used technology for remediation of polluted waters. This process is typically described by sorption isotherms, with one of the most used models, the Polanyi-Dubinin-Manes (PDM) equation, including water solubility (Sw ) as a normalizing factor. In case of pharmaceutical active compounds (PhACs), Sw depends on the pH of the environment due to the ionic/ionizable behavior of these chemicals, a fact frequently ignored in sorption studies of PhACs...
April 16, 2024: Journal of Hazardous Materials
#16
JOURNAL ARTICLE
Angélica M Rosado-Quiñones, Emilee E Colón-Lorenzo, Zarna Rajeshkumar Pala, Jürgen Bosch, Karl Kudyba, Heather Kudyba, Susan E Leed, Norma Roncal, Abel Baerga-Ortiz, Abiel Roche-Lima, Yamil Gerena, David A Fidock, Alison Roth, Joel Vega-Rodríguez, Adelfa E Serrano
The development of novel antiplasmodial compounds with broad-spectrum activity against different stages of Plasmodium parasites is crucial to prevent malaria disease and parasite transmission. This study evaluated the antiplasmodial activity of seven novel hydrazone compounds (referred to as CB compounds: CB-27, CB-41, CB-50, CB-53, CB-58, CB-59, and CB-61) against multiple stages of Plasmodium parasites. All CB compounds inhibited blood stage proliferation of drug-resistant or sensitive strains of Plasmodium falciparum in the low micromolar to nanomolar range...
April 19, 2024: Antimicrobial Agents and Chemotherapy
#17
JOURNAL ARTICLE
Sara Torres-Esquius, Francisco Beas, Tzu Hua Chen-Liang, Helena Pomares, Marta Santiago, Nicolás Díaz Varela, Alessandro Liquori, Francisca Hernandez, Blanca Xicoy, Lourdes Hermosín, Montserrat Arnan, Bárbara Tazón-Vega, Adoración Blanco, José Cervera, María Diez-Campelo, María Luisa Lozano, David Valcárcel, Francesc Bosch, Maria Julia Montoro, Andrés Jerez
Patients aged 50 or above diagnosed with myeloid neoplasms (MNs) are typically not candidates for germline testing. However, approximately 8% carry pathogenic germline variants. Allogeneic haematopoietic stem cell transplantation (alloHSCT) remains an option for those aged over 50; neglecting germline testing could mask the risk for relative donor cell-derived MN. We propose a germline-augmented somatic panel (GASP), combining MN predisposition genes with a myeloid somatic panel for timely germline variant identification when initial testing is not indicated...
April 19, 2024: British Journal of Haematology
#18
JOURNAL ARTICLE
Guillermo Angeles, Carolina Madero-Vega
PREMISE: During the COVID-19 pandemic lockdown, all laboratory work was suspended, and we were obliged to work from home, causing delays in our research. As the disruption to supply chains made it difficult to obtain our regular lab supplies, we were obliged to search for substitutes. We became familiar with a plastic material known as biaxially oriented polypropylene (BOPP) that is widely used in the food industry for wrapping or storing fruits, vegetables, and meat. BOPP is easily dissolved in organic solvents such as xylenes, acetone, or thinner, but these reagents are very toxic, flammable, and can cause nausea in some users...
2024: Applications in Plant Sciences
#19
JOURNAL ARTICLE
Laura Boswell, Arturo Vega-Beyhart, Miquel Blasco, Luis F Quintana, Gabriela Rodríguez, Daniela Díaz-Catalán, Carme Vilardell, María Claro, Mireia Mora, Antonio J Amor, Gregori Casals, Felicia A Hanzu
OBJECTIVE: We compared hair cortisol (HC) with classic tests of the hypothalamic-pituitary-adrenal (HPA) axis in chronic kidney disease (CKD) and assessed its association with kidney and cardiometabolic status. DESIGN AND METHODS: A cross-sectional study of 48 patients with CKD stages I-IV, matched by age, sex, and BMI with 24 healthy controls (CTR) was performed. Metabolic comorbidities, body composition, and HPA axis function were studied. RESULTS: A total of 72 subjects (age 52...
2024: Frontiers in Endocrinology
#20
JOURNAL ARTICLE
Eduardo A Vega, Fernando Rotellar
No abstract text is available yet for this article.
April 18, 2024: Annals of Surgical Oncology
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