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https://www.readbyqxmd.com/read/28433925/low-dose-pollutant-mixture-triggers-metabolic-disturbances-in-female-mice-leading-to-common-and-specific-features-as-compared-to-a-high-fat-diet
#1
Emmanuel Labaronne, Claudie Pinteur, Nathalie Vega, Sandra Pesenti, Benoit Julien, Emmanuelle Meugnier-Fouilloux, Hubert Vidal, Danielle Naville, Brigitte Le Magueresse-Battistoni
Environmental pollutants are potential etiologic factors of obesity and diabetes that reach epidemic proportions worldwide. However, it is important to determine if pollutants could exert metabolic defects without directly inducing obesity. The metabolic disturbances triggered in nonobese mice lifelong exposed to a mixture of low-dose pollutants (2,3,7,8-tetrachlorodibenzo-p-dioxine, polychlorinated biphenyl 153, diethylhexyl-phthalate, and bisphenol A) were compared with changes provoked by a high-fat high-sucrose (HFHS) diet not containing the pollutant mixture...
April 8, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28433805/chronic-early-childhood-exposure-to-arsenic-is-associated-with-a-tnf-mediated-proteomic-signaling-response
#2
Lisa Smeester, Paige A Bommarito, Elizabeth M Martin, Rogelio Recio-Vega, Tania Gonzalez-Cortes, Edgar Olivas-Calderon, R Clark Lantz, Rebecca C Fry
Exposure to inorganic arsenic (iAs) in drinking water is a global public health concern and is associated with a range of health outcomes, including immune dysfunction. Children are a particularly sensitive population to the effects of inorganic arsenic, yet the biological mechanisms underlying adverse health outcomes are understudied. Here we used a proteomic approach to examine the effects of iAs exposure on circulating serum protein levels in a cross-sectional children's cohort in Mexico. To identify iAs-associated proteins, levels of total urinary arsenic (U-tAs) and its metabolites were determined and serum proteins assessed for differences in expression...
April 8, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28433331/-decrease-in-the-incidence-of-chickenpox-in-the-community-of-madrid-after-universal-childhood-immunization-years-2001-2015
#3
Luis García Comas, Pello Latasa Zamalloa, Guadalupe Alemán Vega, María Ordobás Gavín, Araceli Arce Arnáez, Inmaculada Rodero Garduño, Alicia Estirado Gómez, Ester Insúa Marisquerena
OBJECTIVE: Varicella vaccine was recommended in the Community of Madrid (CM) at 15months of age between November 2006 and December 2013. The objective was to describe the impact of vaccination on the incidence of varicella in the CM during the period 2001-2015. DESIGN: A descriptive study of cases of varicella reported to the Sentinel Physician Network of the CM and the cases recorded in the Minimum Basic Data Set at hospital discharge was carried out. Total incidence of cases and of hospital admissions were calculated, as well as specific incidence by age and sex...
April 19, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28433159/glucuronoarabinoxylans-as-major-cell-walls-polymers-from-young-shoots-of-the-woody-bamboo-phyllostachys-aurea
#4
Víctor Martín Zelaya, Paula Virginia Fernández, Andrea Susana Vega, Anita Ida Mantese, Ana Ailén Federico, Marina Ciancia
Young shoots of Phyllostachys aurea showed glucuronoarabinoxylans (GAX) as the major hemicellulosic components, being extracted in major amounts with 1M KOH (ratio Xyl:Ara:GlcA, 100:67:8), but also with water, showing a broad structural variability. Mixed linkage glucans were also present, but in minor amounts, mostly concentrated in the 4M KOH extracts, while pectin polymers were very scarce. Arabinogalactan proteins were an important part of water extracts, determined by the presence of the typical arabinogalactan structures (3- and 6-linked Gal p; terminal and 5-linked Ara f), in addition to small amounts of hydroxyproline (2-3% of total protein) and positive reaction to Yariv's reagent...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28430315/adding-access-blood-flow-surveillance-reduces-thrombosis-and-improves-arteriovenous-fistula-patency-a-randomized-controlled-trial
#5
Inés Aragoncillo, Soraya Abad, Silvia Caldés, Yésika Amézquita, Almudena Vega, Antonio Cirugeda, Cristina Moratilla, José Ibeas, Ramón Roca-Tey, Cristina Fernández, Nicolás Macías, Borja Quiroga, Ana Blanco, Maite Villaverde, Caridad Ruiz, Belén Martín, Asunción M Ruiz, Jara Ampuero, Fernando de Alvaro, Juan M López-Gómez
PURPOSE: Stenosis is the main cause of arteriovenous fistula (AVF) failure. It is still unclear whether surveillance based on vascular access blood flow (QA) enhances AVF function and longevity. METHODS: We conducted a three-year follow-up randomized, controlled, multicenter, open-label trial to compare QA-based surveillance and pre-emptive repair of subclinical stenosis with standard monitoring/surveillance techniques in prevalent mature AVFs. AVFs were randomized to either the control group (surveillance based on classic alarm criteria; n = 104) or to the QA group (QA measured quarterly using Doppler ultrasound [M-Turbo®] and ultrasound dilution [Transonic®] added to classic surveillance; n = 103)...
April 20, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28430288/mesenchymal-proangiogenic-factor-ykl-40-related-to-glioblastomas-and-its-relationship-with-the-subventricular-zone
#6
Kelvin M Pińa Batista, Sayoa Alvarez de Eulate-Beramendi, Kenia Y Álvarez Reyes de Pińa, Pedro Reimunde Figueira, Adan Fernandez Canal, Josué M Avecillas Chasin, Ángela Meilan, Rodrigo Ugalde, Ivan Fernandez Vega
<i>Glioblastoma is the most common primary brain tumor. Despite multimodality therapy with aggressive microsurgical resection and adjuvant chemotherapy and radiotherapy, the median survival is below 15 months. Glioblastomas are heterogeneous tumors with high resistance to most chemotherapeutic drugs. According to reliable evidence, YKL-40, one of the best investigated chitinase-like protein, may facilitate invasion, migration and angiogenesis, and could be also responsible for temozolomide resistance in glioblastoma, thus conferring a dismal prognosis...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28430215/relationship-of-the-drying-process-of-a-corn-grain-with-the-thermal-emissivity-and-optical-interference-in-the-mid-infrared-range
#7
Carlos Villaseñor-Mora, Francisco J Gantes-Nunez, Arturo Gonzalez-Vega, Victor H Hernandez-Gonzalez
A study of the effect of the thin layer of free water in corn kernels on the emissivity and interference in the mid infrared range was performed. The emissivity was measured through thermal infrared images by direct method for 8 days, allowing observance that the thickness of free water modifies the quantity of emitted energy and emissivity; however, in the first days when the layer of free water is not optically thick the interference caused by the thin film of superficial water averts a correct measurement of the emissivity...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28427559/stress-induced-nlrp3-inflammasome-in-human-diseases
#8
Elísabet Alcocer-Gómez, Beatriz Castejón-Vega, Mario D Cordero
Stress is a complex event that induces disturbances to physiological and psychological homeostasis, and it may have a detrimental impact on certain brain and physiological functions. In the last years, a dual role of the stress effect has been studied in order to elucidate the molecular mechanism by which can induce physiological symptoms after psychological stress exposition and vice versa. In this sense, inflammation has been proposed as an important starring. And in the same line, the inflammasome complex has emerged to give responses because of its role of stress sensor...
2017: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/28419796/-third-working-conditions-and-health-survey-in-navarre-spain-main-findings
#9
Vega García
OBJECTIVE: To describe health problems and working conditions perceived by workers of Navarra, Spain. METHODS: Conduct of the Third Survey of Working Conditions and Health in Navarre. We administered the Seventh Spanish National Survey of Working Conditions questionnaire by personal interviews conducted in the workers' homes between October 2014 and December 2014, and using a three-stage stratified sampling approach, by economic activity, work establishment size and gender...
April 2017: Archivos de Prevención de Riesgos Laborales
https://www.readbyqxmd.com/read/28419495/giant-proliferating-trichilemmal-cyst-arising-from-a-nevus-sebaceus-growing-for-thirty-years
#10
Scott F Lindsey, Divya Aickara, Alexandra Price, Janelle Pavlis, Erin X Wei, George Elgart, Jeong Hee Cho-Vega
Nevus sebaceus of Jadassohn, a congenital cutaneous hamartoma, has the potential to develop into various epidermal adnexal-origin neoplasms. While the most common neoplasms are trichoblastoma or syringocystadenoma, proliferating trichilemmal cysts are exceptionally rare. We report a case of a 63-year-old Cuban male with a giant proliferating trichilemmal cyst arising from a nevus sebaceus on the right shoulder which had been growing for 30 years. Proliferating trichilemmal cysts arising from nevus sebaceus cases are difficult to diagnose clinically and histologically since they are very rare and have not been defined by exact diagnostic criteria...
April 17, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28417239/incidental-gallbladder-cancer-residual-cancer-discovered-at-oncologic-extended-resection-determines-outcome-a-report-from-high-and-low-incidence-countries
#11
Eduardo Vinuela, Eduardo A Vega, Suguru Yamashita, Marcel Sanhueza, Rosemarie Mege, Gabriel Cavada, Thomas A Aloia, Yun Shin Chun, Jeffrey E Lee, Jean-Nicolas Vauthey, Claudius Conrad
BACKGROUND: Gallbladder cancer detected incidentally after cholecystectomy (IGBC) currently is the most common diagnosis of gallbladder cancer, and oncologic extended resection (OER) is recommended for tumors classified higher than T1b. However, the precise prognostic significance of residual cancer (RC) found at the time of OER has not been well established. This analysis aimed to determine the prognostic impact of RC found in patients with IGBC undergoing OER. METHODS: Outcomes for IGBC at a center for a low-incidence country (USA) and a high-incidence country (Chile) between January 1999 and June 2015 were analyzed...
April 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28414703/recruitment-methods-and-descriptive-results-of-a-physiologic-assessment-of-latino-farmworkers-the-california-heat-illness-prevention-study
#12
Diane C Mitchell, Javier Castro, Tracey L Armitage, Alondra J Vega-Arroyo, Sally C Moyce, Daniel J Tancredi, Deborah H Bennett, James H Jones, Tord Kjellstrom, Marc B Schenker
OBJECTIVE: The California heat illness prevention study (CHIPS) devised methodology and collected physiological data to assess heat related illness (HRI) risk in Latino farmworkers. METHODS: Bilingual researchers monitored HRI across a workshift, recording core temperature, work rate (metabolic equivalents [METs]), and heart rate at minute intervals. Hydration status was assessed by changes in weight and blood osmolality. Personal data loggers and a weather station measured exposure to heat...
April 14, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28413952/building-new-bridges-between-in-vitro-and-in-vivo-in-early-drug-discovery-where-molecular-modeling-meets-systems-biology
#13
Robert A Pearlstein, Daniel J J McKay, Viktor Hornak, Callum Dickson, Andrei Golosov, Tyler Harrison, Camilo Velez-Vega, José Duca
Cellular drug targets exist within networked function generating systems whose constituent molecular species undergo dynamic interdependent non-equilibrium state transitions in response to specific perturbations (i.e. inputs). Cellular phenotypic behaviors are manifest through the integrated behaviors of such networks. However, in vitro data are frequently measured and/or interpreted with empirical equilibrium or steady state models (e.g. Hill, Michaelis-Menten, Briggs-Haldane) relevant to isolated target populations...
April 14, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28411128/the-effects-of-experimental-gestational-hypertension-on-maternal-blood-pressure-and-fluid-intake-and-pre-weanling-hypothalamic-neuronal-activity
#14
Juan Arguelles, Carmen Perillan, Terry G Beltz, Baojian Xue, Daniel Badaue-Passos, Jose A Vega, Alan Kim Johnson
To examine the fetal programming effects of maternal hypertension, natriophilia and hyperreninemia [experimentally induced in rats by partial inter-renal aortic ligature (PAL) prior to mating] fos immunoreactivity was studied in 6-day-old offspring of PAL and control mothers. The purposes of the present set of experiments were twofold. The first was to characterize the effects of PAL on the mother's arterial blood pressure and intake of salt (1.8% NaCl solution) and water over the course of gestation. Second, was to study the pattern of neuronal activation in key brain areas of 6-day-old offspring treated with the dipsogen isoproterenol that were from PAL and control mothers...
April 11, 2017: Appetite
https://www.readbyqxmd.com/read/28407164/intraocular-pressure-after-implantation-of-a-phakic-collamer-intraocular-lens-with-a-central-hole
#15
Ignacio Rodríguez-Una, Pedro Pablo Rodríguez-Calvo, Luis Fernández-Vega Cueto, Carlos Lisa, Andrés Fernández-Vega Cueto, José F Alfonso
PURPOSE: To investigate the middle-term intraocular pressure (IOP) results after implantation of a posterior chamber collagen copolymer phakic intraocular lens (IOL) (V4c Visian; STAAR Surgical Co., Nidau, Switzerland) with a central hole in patients with myopia. METHODS: This retrospective study enrolled patients who had implantation of a phakic IOL with a central hole. IOP, central vault, and adverse events were evaluated 1, 3, 6, 12, and 24 months postoperatively...
April 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28405935/4-chlorodiazepam-protects-mitochondria-in-t98g-astrocyte-cell-line-from-glucose-deprivation
#16
Eliana Baez, Gina Paola Guio-Vega, Valentina Echeverria, Daniel Andres Sandoval-Rueda, George E Barreto
The translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor (PBR), is considered an important regulator of steroidogenesis and a potential therapeutic target in neurological disorders. Previous evidence suggests that TSPO ligands can protect cells during injury and prevent apoptosis in central nervous system (CNS) cells. However, its actions on astrocytic cells under metabolic injury are not well understood. In this study, we explored whether 4'-chlorodiazepam (Ro5-4864), a TSPO ligand, might protect astrocyte mitochondria under glucose deprivation...
April 13, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28405637/optimizing-interactive-development-of-data-intensive-applications
#17
Matteo Interlandi, Sai Deep Tetali, Muhammad Ali Gulzar, Joseph Noor, Tyson Condie, Miryung Kim, Todd Millstein
Modern Data-Intensive Scalable Computing (DISC) systems are designed to process data through batch jobs that execute programs (e.g., queries) compiled from a high-level language. These programs are often developed interactively by posing ad-hoc queries over the base data until a desired result is generated. We observe that there can be significant overlap in the structure of these queries used to derive the final program. Yet, each successive execution of a slightly modified query is performed anew, which can significantly increase the development cycle...
October 2016: Proceedings of the ... ACM Symposium on Cloud Computing [electronic Resource]: SOCC ... ... SoCC (Conference)
https://www.readbyqxmd.com/read/28403382/molecular-profiling-of-multiple-primary-merkel-cell-carcinoma-to-distinguish-genetically-distinct-tumors-from-clonally-related-metastases
#18
Kelly L Harms, Lorena Lazo de la Vega, Daniel H Hovelson, Samantha Rahrig, Andi K Cani, Chia-Jen Liu, Douglas R Fullen, Min Wang, Aleodor A Andea, Christopher K Bichakjian, Timothy M Johnson, Scott A Tomlins, Paul W Harms
Importance: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma. In rare cases, the development of an additional cutaneous MCC tumor is clinically consistent with a second primary MCC tumor rather than a cutaneous metastasis, which has important treatment and prognostic implications. Objective: To evaluate genetic relatedness in 4 cases with the clinical diagnosis of multiple primary MCCs. Design, Setting, and Participants: In this case series, 7 cases of clinically designated multiple primary MCC were identified; 4 cases met inclusion criteria for next-generation sequencing (NGS) analysis...
April 12, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28402454/adalimumab-vs-azathioprine-in-the-prevention-of-postoperative-crohn-s-disease-recurrence-a-geteccu-randomized-trial
#19
Antonio López-Sanromán, Isabel Vera-Mendoza, Eugeni Domènech, Carlos Taxonera, Vicente Vega Ruiz, Ignacio Marín-Jiménez, Jordi Guardiola, Luisa Castro, María Esteve, Eva Iglesias, Daniel Ceballos, Pilar Martínez-Montiel, Javier P Gisbert, Miguel Mínguez, Ana Echarri, Xavier Calvet, Jesús Barrio, Joaquín Hinojosa, María Dolores Martín-Arranz, Lucía Márquez-Mosquera, Fernando Bermejo, Jordi Rimola, Vicente Pons, Pilar Nos
Background and Aims: Postoperative recurrence of Crohn's disease (POR-CD) is almost certain if no prophylaxis is administered. Evidence for optimal treatment is lacking. Our aim was to compare the efficacy of adalimumab (ADA) and azathioprine (AZA) in this setting. Methods: We performed a phase 3, 52-week, multicenter, randomized, superiority study (APPRECIA), in which patients with ileocolic resection were randomized either to ADA 160-80-40 mg SC or AZA 2.5 mg/kg/d, both associated to metronidazole...
April 11, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28401572/morphological-structures-for-potential-sperm-storage-in-poeciliid-fishes-does-superfetation-matter
#20
Claudia Olivera-Tlahuel, Maricela Villagrán-Santa Cruz, Norma A Moreno-Mendoza, J Jaime Zúñiga-Vega
Sperm storage within the female reproductive tract has been reported as a reproductive strategy in several species of vertebrates and invertebrates. However, the morphological structures that allow for sperm to be stored and kept viable for long periods are relatively unknown in osteichthyes. We use histological and stereological tools to identify and quantify sperm storage structures (spermathecae) in 12 species of viviparous Poeciliidae. We found spermathecae in nine species, six of which exhibit superfetation (the ability of females to simultaneously carry within the ovary two or more broods of embryos at different stages of development)...
April 11, 2017: Journal of Morphology
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