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https://www.readbyqxmd.com/read/29143774/disrupting-vegf-vegfr1-interaction-de-novo-designed-linear-helical-peptides-to-mimic-the-vegf13-25-fragment
#1
Beatriz Balsera, M Ángeles Bonache, Marie Reille-Seroussi, Nathalie Gagey-Eilstein, Michel Vidal, Rosario González-Muñiz, María Jesús Pérez de Vega
The interaction between vascular endothelial growth factor (VEGF) and its receptors (VEGFR) has important implications in angiogenesis and cancer, which moved us to search for peptide derivatives able to block this protein-protein interaction. In a previous work we had described a collection of linear 13-mer peptides specially designed to adopt helical conformations (Ac-SSEEX⁵ARNX⁸AAX(12)N-NH₂), as well as the evaluation of seven library components for the inhibition of the interaction of VEGF with its Receptor 1 (VEGFR1)...
October 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29142954/asymmetric-dimethylarginine-adma-levels-are-lower-in-hemodialysis-patients%C3%A2-treated-with-paricalcitol
#2
Elena Oliva-Damaso, Nestor Oliva-Damaso, Francisco Rodriguez-Esparragon, Juan Payan, Alberto Marañes, Yanet Parodis, Lopez Eduardo Baamonde-Laborda, Nicanor Vega Diaz, Jose Carlos Rodriguez-Perez
Introduction: Chronic kidney disease is a major public health problem. In the last decade, it has been shown that the early stages of chronic kidney disease are associated with an inflammatory condition involving an increased risk of cardiovascular morbidity and long-term mortality. In patients with chronic kidney disease and more specifically those on hemodialysis, cardiovascular events are the most common cause of death. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase and may be an independent risk factor for endothelial dysfunction and cardiovascular disease...
March 2017: KI Reports
https://www.readbyqxmd.com/read/29142950/a-familial-infantile-renal-failure
#3
Sidharth K Sethi, Nikita Wadhwani, Pranaw Jha, Rajan Duggal, Virginia Vega-Warner, Rupesh Raina, Shyam B Bansal, Vijay Kher, Matthew G Sampson, Edgar A Otto
No abstract text is available yet for this article.
March 2017: KI Reports
https://www.readbyqxmd.com/read/29142317/the-maternal-genetic-make-up-of-the-iberian-peninsula-between-the-neolithic-and-the-early-bronze-age
#4
Anna Szécsényi-Nagy, Christina Roth, Guido Brandt, Cristina Rihuete-Herrada, Cristina Tejedor-Rodríguez, Petra Held, Íñigo García-Martínez-de-Lagrán, Héctor Arcusa Magallón, Stephanie Zesch, Corina Knipper, Eszter Bánffy, Susanne Friederich, Harald Meller, Primitiva Bueno Ramírez, Rosa Barroso Bermejo, Rodrigo de Balbín Behrmann, Ana M Herrero-Corral, Raúl Flores Fernández, Carmen Alonso Fernández, Javier Jiménez Echevarria, Laura Rindlisbacher, Camila Oliart, María-Inés Fregeiro, Ignacio Soriano, Oriol Vicente, Rafael Micó, Vicente Lull, Jorge Soler Díaz, Juan Antonio López Padilla, Consuelo Roca de Togores Muñoz, Mauro S Hernández Pérez, Francisco Javier Jover Maestre, Joaquín Lomba Maurandi, Azucena Avilés Fernández, Katina T Lillios, Ana Maria Silva, Miguel Magalhães Ramalho, Luiz Miguel Oosterbeek, Claudia Cunha, Anna J Waterman, Jordi Roig Buxó, Andrés Martínez, Juana Ponce Martínez, Mark Hunt Ortiz, Juan Carlos Mejías-García, Juan Carlos Pecero Espín, Rosario Cruz-Auñón Briones, Tiago Tomé, Eduardo Carmona Ballestero, João Luís Cardoso, Ana Cristina Araújo, Corina Liesau von Lettow-Vorbeck, Concepción Blasco Bosqued, Patricia Ríos Mendoza, Ana Pujante, José I Royo-Guillén, Marco Aurelio Esquembre Beviá, Victor Manuel Dos Santos Goncalves, Rui Parreira, Elena Morán Hernández, Elena Méndez Izquierdo, Jorge Vega Y Miguel, Roberto Menduiña García, Victoria Martínez Calvo, Oscar López Jiménez, Johannes Krause, Sandra L Pichler, Rafael Garrido-Pena, Michael Kunst, Roberto Risch, Manuel A Rojo-Guerra, Wolfgang Haak, Kurt W Alt
Agriculture first reached the Iberian Peninsula around 5700 BCE. However, little is known about the genetic structure and changes of prehistoric populations in different geographic areas of Iberia. In our study, we focus on the maternal genetic makeup of the Neolithic (~ 5500-3000 BCE), Chalcolithic (~ 3000-2200 BCE) and Early Bronze Age (~ 2200-1500 BCE). We report ancient mitochondrial DNA results of 213 individuals (151 HVS-I sequences) from the northeast, central, southeast and southwest regions and thus on the largest archaeogenetic dataset from the Peninsula to date...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141748/trypanosoma-cruzi-infection-induces-pannexin-1-channel-opening-in-cardiac-myocytes
#5
Iván Barría, Juan Güiza, Fredi Cifuentes, Pedro Zamorano, Juan C Sáez, Jorge González, José L Vega
Trypanosoma cruzi, the etiological agent of Chagas diseases, invades the cardiac tissue causing acute myocarditis and heart electrical disturbances. In T. cruzi invasion, the parasite induces [Ca(2+)]i transients in the host cells, an essential phenomenon for invasion. To date, knowledge on the mechanism that elicits transients of [Ca(2+)]i during the infection of cardiac myocytes has not been fully characterized. Pannexin1 (Panx1) channel are poorly selective channels found in all vertebrates that serve as a pathway for ATP release...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29138870/insig2-rs7566605-single-nucleotide-variant-and-global-dna-methylation-index-levels-are-associated-with-weight-loss-in-a-personalized-weight-reduction-program
#6
Francesca Pirini, Sebastian Rodriguez-Torres, Bola Grace Ayandibu, María Orera-Clemente, Alberto Gonzalez-de la Vega, Fahcina Lawson, Roland J Thorpe, David Sidransky, Rafael Guerrero-Preston
Single nucleotide polymorphisms associated with lipid metabolism and energy balance are implicated in the weight loss response caused by nutritional interventions. Diet‑induced weight loss is also associated with differential global DNA methylation. DNA methylation has been proposed as a predictive biomarker for weight loss response. Personalized biomarkers for successful weight loss may inform clinical decisions when deciding between behavioral and surgical weight loss interventions. The aim of the present study was to investigate the association between global DNA methylation, genetic variants associated with energy balance and lipid metabolism, and weight loss following a non‑surgical weight loss regimen...
November 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29137863/results-and-functional-outcomes-of-acute-ischemic-stroke-patients-who-underwent-mechanical-thrombectomy-admitted-to-intensive-care-unit
#7
L Viña Soria, L Martín Iglesias, L López Amor, I Astola Hidalgo, R Rodríguez García, L Forcelledo Espina, J A Gonzalo Guerra, S de Cima Iglesias, E Murias Quintana, P Vega Valdés, S Calleja Puerta, D Escudero Augusto
PURPOSE: To study the results and complications of endovascular treatment (EVT) in acute ischemic stroke patients admitted to Intensive Care Unit (ICU). To analyse the possible factors related to mortality and level of disability at ICU discharge and one year after stroke. DESIGN: Observational prospective study. SETTING: Mixed ICU. Third level hospital. PATIENTS: Sixty adult patients. Consecutive sample. INTERVENTIONS: None...
November 11, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/29137700/limitation-of-therapeutic-effort-in-patients-hospitalised-in-departments-of-internal-medicine
#8
R García Caballero, B Herreros, D Real de Asúa, S Gámez, G Vega, L García Olmos
INTRODUCTION: There is little information on the limitation of therapeutic effort (LTE) in patients admitted to hospital internal medicine units. OBJECTIVES: To describe the indicated LTE regimens in the departments of internal medicine and the characteristics of the patients who undergo them. PATIENTS AND METHODS: An observational, descriptive retrospective study was conducted on 4 hospitals of the Community of Madrid. The study collected demographic and comorbidity data and the LTE orders prescribed for all patients who died during a period of 6 months...
November 11, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/29136290/the-role-of-ca-2-dependent-k-channels-at-the-rat-corticostriatal-synapses-revealed-by-paired-pulse-stimulation
#9
Angel A Robles G, Ana V Vega, Carolina Gonzalez-Sandoval, Jaime Barral
Potassium channels play an important role in modulating synaptic activity both at presynaptic and postsynaptic levels. We have shown before that presynaptically located KV and KIR channels modulate the strength of corticostriatal synapses in rat brain, but the role of other types of potassium channels at these synapses remains largely unknown. Here we show that calcium-dependent potassium channels BK-type but not SK-type channels are located presynaptically in corticostriatal synapses. We stimulated cortical neurons in rat brain slices and recorded postsynaptic excitatory potentials (EPSP) in medium spiny neurons (MSN) in dorsal neostriatum...
November 14, 2017: Synapse
https://www.readbyqxmd.com/read/29135323/impact-assessment-of-the-rational-selection-of-training-and-test-sets-on-the-predictive-ability-of-qsar-models
#10
M F Andrada, E G Vega-Hissi, M R Estrada, J C Garro Martinez
This study performed an analysis of the influence of the training and test set rational selection on the quality and predictively of the quantitative structure-activity relationship (QSAR) model. The study was carried out on three different datasets of Influenza Neuraminidase (H1N1) inhibitors. The three datasets were divided into training and test sets using three rational selection methods: based on k-means, Kennard-Stone algorithm and Activity and the results were compared with Random selection. Then, a total of 31,490 mathematical models were developed and those models that presented a determination coefficient higher than: r(2)train > 0...
November 14, 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/29135027/acrosomal-alkalization-triggers-ca-2-release-and-acrosome-reaction-in-mammalian-spermatozoa
#11
EDITORIAL
Julio C Chávez, José L De la Vega-Beltrán, Omar José, Paulina Torres, Takuya Nishigaki, Claudia L Treviño, Alberto Darszon
The sperm acrosome reaction (AR), an essential event for mammalian fertilization, involves Ca(2+) permeability changes leading to exocytosis of the acrosomal vesicle. The acrosome, an intracellular Ca(2+) store whose luminal pH is acidic, contains hydrolytic enzymes. It is known that acrosomal pH (pHacr ) increases during capacitation and this correlates with spontaneous AR. Some AR inducers increase intracellular Ca(2+) concentration ([Ca(2+) ]i ) through Ca(2+) release from internal stores, mainly the acrosome...
November 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29130816/the-role-of-perceived-family-social-support-and-parental-solicitous-responses-in-adjustment-to-bothersome-pain-in-young-people-with-physical-disabilities
#12
Jordi Miró, Rocío de la Vega, Kevin J Gertz, Mark P Jensen, Joyce M Engel
PURPOSE: Family social support and parental solicitous responses have been hypothesised to play an important role in paediatric pain. However, research testing the hypothesised associations between these social domains and measures of adjustment to pain in youths with disabilities and chronic pain is non-existent. METHODS: About 111 youths with physical disabilities and bothersome pain were interviewed and asked to complete measures of average pain intensity, pain interference, family social support, parent solicitous responding, and catastrophising...
November 12, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29130697/-preferences-for-the-attributes-of-home-enteral-nutrition-hen-in-spain-do-caregivers-know-their-patients-preferences
#13
Gabriel Olveira, Miguel Ángel Martínez-Olmos, Belén Fernández de Bobadilla, Mercedes Ferrer, Nuria Virgili, Belén Vega, Mercedes Blanco, Miquel Layola, Luis Lizán, Susana Aceituno
INTRODUCTION: Establishing a home enteral nutrition (HEN) that is adapted to the patient's needs and preferences can improve their quality of life and adherence, contributing to a higher treatment efficiency, better prognosis and cost reduction. As in most cases, patients need total or partial help from their caregivers, and there is a need for evaluating how well do caregivers know their patients' priorities. OBJECTIVES: Exploring patients' preferences for HEN characteristics in Spain, and the concordance between patients and caregivers...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29130078/hepatic-adaptations-to-a-high-fat-diet-in-the-mrl-mouse-strain-are-associated-with-an-inefficient-oxidative-phosphorylation-system
#14
Ahlke Heydemann, Magdalis González-Vega, Tirsit K Berhanu, Aaron J Mull, Ragav Sharma, Jenan Holley-Cuthrell
The MRL mice are resistant to a 12-week high fat diet (HFD) feeding protocol, with the proximal cause being an increased basal pAMPK(T172) expression in the skeletal muscle. Here, we test if this lack of pathology extends to the liver at both the tissue and cellular levels and its correlation to pAMPK(T172) levels. MRL and B6 mice were subjected to 12 weeks of diet intervention and tissues were either fixed for histology or snap-frozen for further processing (n= 3-6, per group). The HFD MRL mice remain insulin and glucose sensitive after 12 weeks of HFD...
December 2016: Jacobs J Diabetes Endocrinol
https://www.readbyqxmd.com/read/29126791/the-cardioprotective-effects-of-epicatechin-are-mediated-through-arginase-activity-inhibition-in-a-murine-model-of-ischemia-reperfusion
#15
Pilar Ortiz-Vilchis, Miguel Ortiz-Flores, Marcela Pacheco, Israel Ramirez-Sanchez, Aldo Moreno-Ulloa, Lourdes Vega, Alicia Ortiz, Francisco Villarreal, Ivan Rubio-Gayosso, Nayelli Najera, Eduardo Meaney, Guillermo Ceballos
The production of nitric oxide (NO) by nitric oxide synthases (NOS) depends on the bioavailability of L-arginine as NOS competes with arginase for this common substrate. As arginase activity increases, less NO is produced and adverse cardiovascular consequences can emerge. (-)-Epicatechin (EPI), the most abundant flavonoid in cacao, has been reported to stimulate endothelial and neuronal NOS expression and function leading to enhanced vascular function and cardioprotective effects. However, little is known about the effects of EPI on myocardial arginase activity...
November 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29122777/genetic-predictors-of-response-to-systemic-therapy-in-esophagogastric-cancer
#16
Yelena Y Janjigian, Francisco Sanchez-Vega, Philip Jonsson, Walid K Chatila, Jaclyn F Hechtman, Geoffrey Y Ku, Jamie C Riches, Yaelle Tuvy, Ritika Kundra, Nancy Bouvier, Efsevia Vakiani, Jianjiong Gao, Zachary J Heins, Benjamin E Gross, David P Kelsen, Liying Zhang, Vivian E Strong, Mark Schattner, Hans Gerdes, Daniel G Coit, Manjit Bains, Zsofia K Stadler, Valerie W Rusch, David R Jones, Daniela Molena, Jinru Shia, Mark E Robson, Marinela Capanu, Sumit Middha, Ahmet Zehir, David M Hyman, Maurizio Scaltriti, Marc Ladanyi, Neal Rosen, David H Ilson, Michael F Berger, Laura Tang, Barry S Taylor, David B Solit, Nikolaus Schultz
The incidence of esophagogastric cancer is rapidly rising but only a minority of patients derive durable benefit from current therapies. Chemotherapy as well as anti-HER2 and PD-1 antibodies are standard treatments. To identify predictive biomarkers of drug sensitivity and mechanisms of resistance, we implemented prospective tumor sequencing of metastatic esophagogastric cancer patients. There was no association between HRD defects and response to platinum-based chemotherapy. Patients with MSI-H tumors were intrinsically resistant to chemotherapy but more likely to achieve durable responses to immunotherapy...
November 9, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29121407/strong-and-frequent-t-cell-responses-to-the-minor-allergen-phl-p-12-in-spanish-patients-ige-sensitized-to-profilins
#17
Gitte Lund, Stephanie Brand, Tania Ramos, Lucia Jimeno, Patrice Boissy, Francisco Vega, Maria Arina, Lars Harder Christensen, Ilka Hoof, Kåre Hvalsøe Meno, Domingo Barber, Carlos Blanco, Peter Adler Würtzen, Peter Sejer Andersen
BACKGROUND: Profilins are dominant pan-allergens known to cause cross-sensitization, leading to clinical symptoms such as the pollen food syndrome. This study aims to determine the T-cell response to Phl p 12 in profilin-sensitized patients, by measuring the prevalence, strength and cross-reactivity to clinically relevant profilins. METHODS: The release of Phl p allergens from pollen was determined by mass spectrometry and immunochemistry. T-cell responses, epitope mapping and cross-reactivity to profilins (Phl p 12, Ole e 2, Bet v 2, and Mal d 4) were measured in-vitro using PBMCs from 26 Spanish grass allergic donors IgE-sensitized to profilin...
November 9, 2017: Allergy
https://www.readbyqxmd.com/read/29119305/the-development-and-psychometric-properties-of-the-immigration-law-concerns-scale-ilcs-for-hiv-testing
#18
Julia Lechuga, Carol L Galletly, Michelle R Broaddus, Julia B Dickson-Gomez, Laura R Glasman, Timothy L McAuliffe, Miriam Y Vega, Sarah LeGrand, Carla A Mena, Morgan L Barlow, Erik Valera, Judith I Montenegro
To develop, pilot test, and conduct psychometric analyses of an innovative scale measuring the influence of perceived immigration laws on Latino migrants' HIV-testing behavior. The Immigration Law Concerns Scale (ILCS) was developed in three phases: Phase 1 involved a review of law and literature, generation of scale items, consultation with project advisors, and subsequent revision of the scale. Phase 2 involved systematic translation- back translation and consensus-based editorial processes conducted by members of a bilingual and multi-national study team...
November 8, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29119175/protective-effect-of-selenium-supplementation-following-oxidative-stress-mediated-by-glucose-on-retinal-pigment-epithelium
#19
Raquel González de Vega, Montserrat García, María Luisa Fernández-Sánchez, Héctor González-Iglesias, Alfredo Sanz-Medel
There are many conditions that affect the retina. However, diabetic retinopathy (RD) as a complication of Diabetes Mellitus continues to be the leading cause of blindness in working people globally. Diabetic retinopathy is an ocular complication of diabetes that is caused by the deterioration of the blood vessels that supply the retina, which has the consequence that the vision deteriorates irreversibly. The retina, and specifically the retinal pigment epithelium (RPE) is the only neural tissue that is exposed directly and frequently to light, which favors the oxidation of lipids that become extremely toxic to the cells of the retina...
November 9, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29119124/spanish-consensus-statement-clinical-management-and-treatment-of-tendinopathies-in-sport
#20
Tomas Fernandez-Jaén, Guillermo Álvarez Rey, Francisco Angulo, Jordi Ardevol Cuesta, Rafael Arriaza Loureda, Fernando Ávila España, Juan Ayala, Ramón Balius Matas, Fernando Baró Pazos, Juan de Dios Beas Jiménez, Jorge Candel Rosell, César Cobián Fernandez, Mª Del Pilar Doñoro Cuevas, Francisco Esparza Ros, Josefina Espejo Colmenero, Jorge Fernández de Prado, Juan José García Cota, Jose Ignacio Garrido González, Carlos Gonzalez de Vega, Manuela González Santander, Miguel Ángel Herrador Munilla, Francisco Ivorra Ruiz, Fernando Jiménez Díaz, Antonio Maestro Fernandez, Pedro Manonelles Marqueta, Juan José Muñoz Benito, Ramón Olivé Vilás, Carles Pedret, Xavier Peirau Teres, José Peña Amaro, Jordi Puigdellivoll Grifell, Juan Pérez San Roque, Christophe Ramírez Parenteu, Juan Ribas Serna, Gil Rodas Font, Mikel Sánchez Álvarez, Carlos Sanchez Marchori, Lluis Til Perez, Rosario Ureña Durán, Miguel Del Valle Soto, José María Villalón Alonso, Pedro Guillen García
On October 15, 2016, experts met at Clínica CEMTRO in Madrid, Spain, under the patronage of the Spanish Society for Sports Traumatology (SETRADE), the Spanish Society of Sports Medicine (SEMED), the Spanish Association of Medical Services for Football Clubs (AEMEF), the Spanish Association of Medical Services for Basketball Clubs (AEMB), F.C. Barcelona, and Clínica CEMTRO. The purpose was to consider the most appropriate clinical management and treatment of tendinopathies in sports, based on proven scientific data described in the medical literature as well as on each expert's experience...
October 2017: Orthopaedic Journal of Sports Medicine
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