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https://www.readbyqxmd.com/read/28239654/flow-virometric-sorting-and-analysis-of-hiv-quasispecies-from-plasma
#1
Thomas Musich, Jennifer C Jones, Brandon F Keele, Lisa M Miller Jenkins, Thorsten Demberg, Thomas S Uldrick, Robert Yarchoan, Marjorie Robert-Guroff
Flow cytometry is utilized extensively for cellular analysis, but technical limitations have prevented its routine application for characterizing virus. The recent introduction of nanoscale fluorescence-activated cytometric cell sorting now allows analysis of individual virions. Here, we demonstrate staining and sorting of infectious HIV. Fluorescent antibodies specific for cellular molecules found on budding virions were used to label CCR5-tropic Bal HIV and CXCR4-tropic NL4.3 HIV Env-expressing pseudovirions made in THP-1 cells (monocyte/macrophage) and H9 cells (T cells), respectively...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28222036/vascular-risk-factors-are-associated-with-retinal-arteriolar-narrowing-and-venular-widening-in-children-and-adolescents-with-type-1-diabetes
#2
Stuart Keel, Catherine Itsiopoulos, Konstandina Koklanis, Meri Vukicevic, Fergus Cameron, Laima Brazionis
BACKGROUND: The aim of the study was to describe the relationship of retinal arteriolar and venular calibre with vascular risk factors in children and adolescents with type 1 diabetes. METHODS: In this hospital-based cross-sectional study, the medical files of 483 children and adolescents with type 1 diabetes were audited to collect retinal images and relevant clinical data. Retinal vascular calibre was measured using standardised protocols. RESULTS: After multivariable adjustments, a vascular risk profile that included: older age, higher serum creatinine, higher systolic blood pressure (SBP), higher body mass index (BMI), abnormal estimated glomerular filtration rate (eGFR), lower high-density lipoproteins (HDL) cholesterol, longer duration of diabetes and higher serum sodium was associated with narrower central retinal artery equivalent (CRAE) (95% CI=-4...
February 21, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28217113/antimicrobial-and-insecticidal-cyclic-lipopeptides-and-hydrogen-cyanide-produced-by-plant-beneficial-pseudomonas-strains-cha0-cmr12a-and-pcl1391-contribute-to-insect-killing
#3
Pascale Flury, Pilar Vesga, Maria Péchy-Tarr, Nora Aellen, Francesca Dennert, Nicolas Hofer, Karent P Kupferschmied, Peter Kupferschmied, Zane Metla, Zongwang Ma, Sandra Siegfried, Sandra de Weert, Guido Bloemberg, Monica Höfte, Christoph J Keel, Monika Maurhofer
Particular groups of plant-beneficial fluorescent pseudomonads are not only root colonizers that provide plant disease suppression, but in addition are able to infect and kill insect larvae. The mechanisms by which the bacteria manage to infest this alternative host, to overcome its immune system, and to ultimately kill the insect are still largely unknown. However, the investigation of the few virulence factors discovered so far, points to a highly multifactorial nature of insecticidal activity. Antimicrobial compounds produced by fluorescent pseudomonads are effective weapons against a vast diversity of organisms such as fungi, oomycetes, nematodes, and protozoa...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28211455/supermode-density-wave-polariton-condensation-with-a-bose-einstein-condensate-in-a-multimode-cavity
#4
Alicia J Kollár, Alexander T Papageorge, Varun D Vaidya, Yudan Guo, Jonathan Keeling, Benjamin L Lev
Phase transitions, where observable properties of a many-body system change discontinuously, can occur in both open and closed systems. By placing cold atoms in optical cavities and inducing strong coupling between light and excitations of the atoms, one can experimentally study phase transitions of open quantum systems. Here we observe and study a non-equilibrium phase transition, the condensation of supermode-density-wave polaritons. These polaritons are formed from a superposition of cavity photon eigenmodes (a supermode), coupled to atomic density waves of a quantum gas...
February 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28207777/quantifying-the-value-of-perfect-information-in-emergency-vaccination-campaigns
#5
Naomi V Bradbury, William J M Probert, Katriona Shea, Michael C Runge, Christopher J Fonnesbeck, Matt J Keeling, Matthew J Ferrari, Michael J Tildesley
Foot-and-mouth disease outbreaks in non-endemic countries can lead to large economic costs and livestock losses but the use of vaccination has been contentious, partly due to uncertainty about emergency FMD vaccination. Value of information methods can be applied to disease outbreak problems such as FMD in order to investigate the performance improvement from resolving uncertainties. Here we calculate the expected value of resolving uncertainty about vaccine efficacy, time delay to immunity after vaccination and daily vaccination capacity for a hypothetical FMD outbreak in the UK...
February 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28186789/meissner-like-effect-for-a-synthetic-gauge-field-in-multimode-cavity-qed
#6
Kyle E Ballantine, Benjamin L Lev, Jonathan Keeling
Previous realizations of synthetic gauge fields for ultracold atoms do not allow the spatial profile of the field to evolve freely. We propose a scheme which overcomes this restriction by using the light in a multimode cavity with many nearly degenerate transverse modes, in conjunction with Raman coupling, to realize an artificial magnetic field which acts on a Bose-Einstein condensate of neutral atoms. We describe the evolution of such a system and present the results of numerical simulations which show dynamical coupling between the effective field and the matter on which it acts...
January 27, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28161240/survival-of-the-pegged-glenoid-component-in-shoulder-arthroplasty-part-ii
#7
Paul B McLendon, Bradley S Schoch, John W Sperling, Joaquin Sanchez-Sotelo, Cathy D Schleck, Robert H Cofield
BACKGROUND: Loosening of the glenoid component is a primary reason for failure of an anatomic shoulder arthroplasty. Pegged glenoids were designed in an effort to outperform keeled components. This study evaluated the midterm clinical and radiographic survival of a single implant design with implantation of an in-line pegged glenoid component and identified risk factors for radiographic loosening and clinical failure. MATERIALS AND METHODS: There were 330 total shoulder arthroplasties that had been implanted with a cemented, all-polyethylene, in-line pegged glenoid component evaluated with an average clinical follow-up of 7...
February 1, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28158985/implementing-the-keele-stratified-care-model-for-patients-with-low-back-pain-an-observational-impact-study
#8
Adrian Bamford, Andy Nation, Susie Durrell, Lazaros Andronis, Ellen Rule, Hugh McLeod
BACKGROUND: The Keele stratified care model for management of low back pain comprises use of the prognostic STarT Back Screening Tool to allocate patients into one of three risk-defined categories leading to associated risk-specific treatment pathways, such that high-risk patients receive enhanced treatment and more sessions than medium- and low-risk patients. The Keele model is associated with economic benefits and is being widely implemented. The objective was to assess the use of the stratified model following its introduction in an acute hospital physiotherapy department setting in Gloucestershire, England...
February 3, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28158448/virus-driven-inflammation-is-associated-with-the-development-of-bnabs-in-spontaneous-controllers-of-hiv
#9
Anne-Sophie Dugast, Kelly Arnold, Giuseppe Lofano, Sarah Moore, Michelle Hoffner, Melissa Simek, Pascal Poignard, Michael Seaman, Todd Suscovich, Florencia Pereyra, Bruce D Walker, Doug Lauffenburger, Doug Kwon, Brandon F Keele, Galit Alter
No abstract text is available yet for this article.
February 3, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28149678/three-new-karst-dwelling-cnemaspis-strauch-1887-squamata-gekkoniade-from-peninsular-thailand-and-the-phylogenetic-placement-of-c-%C3%A2-punctatonuchalis-and-c-%C3%A2-vandeventeri
#10
Perry Lee Wood, L Lee Grismer, Anchalee Aowphol, César A Aguilar, Micheal Cota, Marta S Grismer, Matthew L Murdoch, Jack W Sites
Three new species of Rock Geckos Cnemaspis lineogularis sp. nov., C. phangngaensis sp. nov., and C. thachanaensis sp. nov. of the chanthaburiensis and siamensis groups are described from the Thai portion of the Thai-Malay Peninsula. These new species are distinguished from all other species in their two respective groups based on a unique combination of morphological characteristics, which is further supported by mitochondrial DNA (mtDNA) from the NADH dehydrogenase subunit 2 gene (ND2). Cnemaspis lineogularis sp...
2017: PeerJ
https://www.readbyqxmd.com/read/28147451/impact-of-the-alexander-technique-on-well-being-a-randomised-controlled-trial-involving-older-adults-with-visual-impairment
#11
Michael Gleeson, Catherine Sherrington, Serigne Lo, Robin Auld, Lisa Keay
BACKGROUND: Older adults with visual loss have high rates of depression, restricted participation and reduced quality of life. We sought to measure the impact of lessons in the Alexander technique on vision-related emotional and social well-being, as secondary outcomes to a study on improving physical functioning in this population. METHODS: This is a single-blind randomised controlled trial. One hundred and twenty community-dwelling adults aged 50 to 90 years with visual impairments were randomised to either 12 Alexander lessons over 12 weeks and usual care or usual care...
February 1, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28147442/emerging-ocular-biomarkers-of-alzheimer-disease
#12
REVIEW
Peter van Wijngaarden, Xavier Hadoux, Mostafa Alwan, Stuart Keel, Mohamed Dirani
Interest in reliable biomarkers of Alzheimer disease, the leading cause of dementia, has been fuelled by challenges in diagnosing the disease and monitoring disease progression as well as the response to therapy. A range of ocular manifestations of Alzheimer disease, including retinal and lens amyloid-beta accumulation, retinal nerve fiber layer loss, and retinal vascular changes, have been proposed as potential biomarkers of the disease. Herein, we examine the evidence regarding the potential value of these ocular biomarkers of Alzheimer disease...
January 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28145932/a-surgical-technique-for-management-of-the-metopic-suture-in-syndromic-craniosynostosis
#13
Jose Rolando Prada-Madrid, Lina Patricia Franco-Chaparro, Miguel Garcia-Wenninger, Tatiana Palomino-Consuegra, Nora Stanford, Diego Alejandro Castañeda-Hernández
OBJECTIVES: The objective is to describe a new surgical procedure developed in the San Jose Pediatric University Hospital for the management of syndromic synostosis of the metopic suture in a patient clinically diagnosed with Saethre-Chotzen syndrome. METHODS: The diagnosis of Saethre-Chotzen syndrome, bilateral coronal sutures, and metopic suture synostoses was made through photographic, anthropometric, exophthalmometric, and computed tomography analysis. The keel-like frontal bone deformity was corrected following resection using a fusiform osteotomy, remodelling was obtained by milling the edges, and the bony fragments were repositioned and fixed on the posterior wall of the frontal bone...
January 31, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28124508/the-wayfinding-experience-of-family-carers-who-learn-to-manage-technical-health-procedures-at-home-a-grounded-theory-study
#14
Janet McDonald, Eileen McKinlay, Sally Keeling, William Levack
BACKGROUND: With more care taking place in the home, family carers play an important role in supporting patients. Some family carers undertake technical health procedures generally managed by health professionals in hospital settings (e.g. managing a tracheostomy or enteral feeding). AIM: To explore how family carers learn to manage technical health procedures in order to help health professionals better understand and support this process. DESIGN AND METHODS: A grounded theory study using data from interviews with 26 New Zealand family carers who managed technical health procedures including nasogastric or gastrostomy feeding, stoma care, urinary catheterisation, tracheostomy management, intravenous therapy, diabetes management and complex wound dressings...
January 25, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28115652/candidate-risk-factors-and-mechanisms-for-tolvaptan-induced-liver-injury-are-identified-using-a-collaborative-cross-approach
#15
Merrie Mosedale, Yunjung Kim, William J Brock, Sharin E Roth, Tim Wiltshire, J Scott Eaddy, Gregory R Keele, Robert W Corty, Yuying Xie, William Valdar, Paul B Watkins
Clinical trials of tolvaptan showed it to be a promising candidate for the treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) but also revealed potential for idiosyncratic drug-induced liver injury (DILI) in this patient population. To identify risk factors and mechanisms underlying tolvaptan DILI, 8 mice in each of 45 strains of the genetically diverse Collaborative Cross (CC) mouse population were treated with a single oral dose of either tolvaptan or vehicle. Significant elevations in plasma alanine aminotransferase (ALT) were observed in tolvaptan-treated animals in 3 of the 45 strains...
January 23, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28114166/association-of-delayed-antimicrobial-therapy-with-one-year-mortality-in-pediatric-sepsis
#16
Moonjoo Han, Julie C Fitzgerald, Fran Balamuth, Luke Keele, Elizabeth R Alpern, Jane Lavelle, Marianne Chilutti, Robert W Grundmeier, Vinay M Nadkarni, Neal J Thomas, Scott L Weiss
OBJECTIVE: Delayed antimicrobial therapy in sepsis is associated with increased hospital mortality, but the impact of antimicrobial timing on long-term outcomes is unknown. We tested the hypothesis that hourly delays to antimicrobial therapy are associated with 1-year mortality in pediatric severe sepsis. DESIGN: Retrospective observational study. SETTING: Quaternary academic pediatric intensive care unit (PICU) from February 1, 2012 to June 30, 2013...
January 20, 2017: Shock
https://www.readbyqxmd.com/read/28110965/baby-it-s-cold-outside-does-it-need-to-be
#17
EDITORIAL
Brent Keeling, Edward P Chen
No abstract text is available yet for this article.
January 9, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28107073/choroidal-vasculopathy-and-retinal-detachment-in-a-bald-eagle-haliaeetus-leucocephalus-with-lead-toxicosis
#18
Ramzi Eid, David Sanchez-Migallon Guzman, Krista A Keller, K Tomo Wiggans, Christopher J Murphy, Elise E B LaDouceur, M Kevin Keel, Christopher M Reilly
A subadult male bald eagle ( Haliaeetus leucocephalus ) was presented for severe depression and weakness. Physical examination findings included depressed mentation, dehydration, sternal recumbency, poor body condition, and bilateral, whole-head, horizontal nystagmus. A heavy-metal panel was performed, and blood lead levels were 6.1 ppm. Treatment for lead poisoning was initiated, including subcutaneous fluids and parenteral calcium-disodium ethylenediaminetetraacetic acid, ceftiofur, and meloxicam. Ophthalmic examination findings included absent menace response, absent dazzle reflex, slow and incomplete direct pupillary light reflex, mild anterior uveitis, incipient cataracts, multifocal retinal tears, and retinal separation in both eyes...
December 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28106908/the-aspirin-story-from-willow-to-wonder-drug
#19
REVIEW
Michael J R Desborough, David M Keeling
The story of the discovery of aspirin stretches back more than 3500 years to when bark from the willow tree was used as a pain reliever and antipyretic. It involves an Oxfordshire clergyman, scientists at a German dye manufacturer, a Nobel Prize-winning discovery and a series of pivotal clinical trials. Aspirin is now the most commonly used drug in the world. Its role in preventing cardiovascular and cerebrovascular disease has been revolutionary and one of the biggest pharmaceutical success stories of the last century...
January 20, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28103123/disease-burden-of-patients-with-asthma-copd-overlap-in-a-us-claims-database-impact-of-icd-9-coding-based-definitions
#20
Keele E Wurst, Samantha St Laurent, David Hinds, Kourtney J Davis
The inclusion of an asthma/chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) population in the 2015 Global Initiative for Chronic Obstructive Lung Disease strategic documents has raised questions about the profile of these patients in clinical practice, as they are mostly excluded from asthma and COPD clinical trials. We estimated the disease burden, co-morbidities, and respiratory treatments of patients with asthma/COPD overlap, utilizing the Truven MarketScan commercial and Medicare databases...
January 19, 2017: COPD
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