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https://www.readbyqxmd.com/read/28078372/fragility-fractures-of-the-spine
#1
EDITORIAL
Oliver Gonschorek, Marius Keel
No abstract text is available yet for this article.
January 11, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28077394/metal-backed-versus-all-polyethylene-unicompartmental-knee-arthroplasty-proximal-tibial-strain-in-an-experimentally-validated-finite-element-model
#2
C E H Scott, M J Eaton, R W Nutton, F A Wade, S L Evans, P Pankaj
OBJECTIVES: Up to 40% of unicompartmental knee arthroplasty (UKA) revisions are performed for unexplained pain which may be caused by elevated proximal tibial bone strain. This study investigates the effect of tibial component metal backing and polyethylene thickness on bone strain in a cemented fixed-bearing medial UKA using a finite element model (FEM) validated experimentally by digital image correlation (DIC) and acoustic emission (AE). MATERIALS AND METHODS: A total of ten composite tibias implanted with all-polyethylene (AP) and metal-backed (MB) tibial components were loaded to 2500 N...
January 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28074776/morphological-classification-of-acromial-spur-correlation-between-rockwood-tilt-view-and-arthroscopic-finding
#3
Pinkawas Kongmalai, Adinun Apivatgaroon, Bancha Chernchujit
: Purpose and hypothesis: Acromion spur is the extrinsic factor for impingement syndrome and rotator cuff tear. The Rockwood tilt view can be used to evaluate prominence of the anterior acromion, however no study has shown the correlation of findings between the Rockwood tilt view and the arthroscopic finding. METHODS: We developed the arthroscopic classification of acromion spur as type 1 flat spur, type 2 bump spur, type 3 heel spur, type 4 keel spur, and type 5 irregular spur...
2017: SICOT-J
https://www.readbyqxmd.com/read/28067466/anterior-lumbar-interbody-fusion-integrated-screw-cages-intrinsic-load-generation-subsidence-and-torsional-stability
#4
Yusuf Assem, Matthew H Pelletier, Ralph J Mobbs, Kevin Phan, William R Walsh
OBJECTIVE: To perform a repeatable idealized in vitro model to evaluate the effects of key design features and integrated screw fixation on unloaded surface engagement, subsidence, and torsional stability. METHODS: We evaluated four different stand-alone anterior lumbar interbody fusion (ALIF) cages with two, three, and four screw designs. Polyurethane (saw-bone) foam blocks were used to simulate the vertebral bone. Fuji Film was used to measure the contact footprint, average pressure, and load generated by fixating the cages with screws...
January 9, 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28063688/crystalloid-fluid-choice-and-clinical-outcomes-in-pediatric-sepsis-a-matched-retrospective-cohort-study
#5
Scott L Weiss, Luke Keele, Fran Balamuth, Neika Vendetti, Rachael Ross, Julie C Fitzgerald, Jeffrey S Gerber
OBJECTIVE: To test the hypothesis that resuscitation with balanced fluids (lactated Ringer [LR]) is associated with improved outcomes compared with normal saline (NS) in pediatric sepsis. STUDY DESIGN: We performed matched analyses using data from 12 529 patients <18 years of age with severe sepsis/septic shock at 382 US hospitals between 2000 and 2013 to compare outcomes with vs without LR as part of initial resuscitation. Patients receiving LR were matched 1:1 to patients receiving only NS (NS group), including separate matches for any (LR-any group) or exclusive (LR-only group) LR use...
January 4, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28061364/de-novo-truncating-variants-in-asxl2-are-associated-with-a-unique-and-recognizable-clinical-phenotype
#6
Vandana Shashi, Loren D M Pena, Katherine Kim, Barbara Burton, Maja Hempel, Kelly Schoch, Magdalena Walkiewicz, Heather M McLaughlin, Megan Cho, Nicholas Stong, Scott E Hickey, Christine M Shuss, Michael S Freemark, Jane S Bellet, Martha Ann Keels, Melanie J Bonner, Maysantoine El-Dairi, Megan Butler, Peter G Kranz, Constance T R M Stumpel, Sylvia Klinkenberg, Karin Oberndorff, Malik Alawi, Rene Santer, Slavé Petrovski, Outi Kuismin, Satu Korpi-Heikkilä, Olli Pietilainen, Palotie Aarno, Mitja I Kurki, Alexander Hoischen, Anna C Need, David B Goldstein, Fanny Kortüm
No abstract text is available yet for this article.
January 5, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28056016/predicting-the-impact-of-intervention-strategies-for-sleeping-sickness-in-two-high-endemicity-health-zones-of-the-democratic-republic-of-congo
#7
Kat S Rock, Steve J Torr, Crispin Lumbala, Matt J Keeling
Two goals have been set for Gambian human African trypanosomiasis (HAT), the first is to achieve elimination as a public health problem in 90% of foci by 2020, and the second is to achieve zero transmission globally by 2030. It remains unclear if certain HAT hotspots could achieve elimination as a public health problem by 2020 and, of greater concern, it appears that current interventions to control HAT in these areas may not be sufficient to achieve zero transmission by 2030. A mathematical model of disease dynamics was used to assess the potential impact of changing the intervention strategy in two high-endemicity health zones of Kwilu province, Democratic Republic of Congo...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28048089/su-f-t-160-commissioning-of-a-single-room-double-scattering-proton-therapy-system
#8
H Jin, S Ahmad, Y Chen, V Keeling, A Lau, M Islam, C Ferreira, S Ferguson
PURPOSE: To report the detailed commissioning experience for a compact double-scattering Mevion S250 proton therapy system at a University Cancer Center site. METHODS: The commissioning of the proton therapy system mainly consisted of ensuring integrity of mechanical and imaging system, beam data collection, and commissioning of a treatment planning system (TPS). First, mechanical alignment and imaging were tested including safety, interlocks, positional accuracy of couch and gantry, image quality, mechanical and imaging isocenter and so on...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047467/su-f-t-143-implementation-of-a-correction-based-output-model-for-a-compact-passively-scattered-proton-therapy-system
#9
S Ferguson, S Ahmad, Y Chen, C Ferreira, M Islam, V Keeling, A Lau, H Jin
PURPOSE: To commission and investigate the accuracy of an output (cGy/MU) prediction model for a compact passively scattered proton therapy system. METHODS: A previously published output prediction model (Sahoo et al, Med Phys, 35, 5088-5097, 2008) was commissioned for our Mevion S250 proton therapy system. This model is a correction-based model that multiplies correction factors (d/MUwnc=ROFxSOBPF xRSFxSOBPOCFxOCRxFSFxISF). These factors accounted for changes in output due to options (12 large, 5 deep, and 7 small), modulation width M, range R, off-center, off-axis, field-size, and off-isocenter...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045990/the-prevalence-of-self-reported-diabetes-in-the-australian-national-eye-health-survey
#10
Stuart Keel, Joshua Foreman, Jing Xie, Peter van Wijngaarden, Hugh R Taylor, Mohamed Dirani
OBJECTIVE: To present the prevalence of self-reported diabetes in Indigenous and non-Indigenous participants in the National Eye Health Survey. RESEARCH DESIGN AND METHODS: 3098 non-Indigenous Australians aged 50-98 years and 1738 Indigenous Australians aged 40-92 years were examined in 30 randomly selected sites, stratified by remoteness. A history of diabetes was obtained using an interviewer-administered questionnaire. RESULTS: 13.91% (431/3098) of non-Indigenous Australians and 37...
2017: PloS One
https://www.readbyqxmd.com/read/28045206/assessment-of-tissue-development-in-fattening-quails-using-the-stable-isotope-technique
#11
J C R Rezende, M M P Sartori, J R Sartori, C Ducatti, J C Denadai, A C Pezzato
We aimed to study the behaviour of tissue renewal in blood, pectoral muscle and keel of fattening quails during their growth and adulthood through carbon-13 turnover using the stable isotope technique. Three hundred male European quails were randomly subjected to six treatments. Diets fed to animals were initially based on corn and soybean meal and were replaced at 0, 7, 14, 21, 28 and 35 days of age with diets of rice grits and soybean meal. These diets have distinct isotopic signals and over time it changes; the tissue will incorporate dietary signal, and then, we can measure the return time for each tissue in each age...
January 3, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28042725/stepwise-illustration-of-teeth-fixation-semi-constrained-cervical-disc-arthroplasty
#12
Chih-Chang Chang, Jau-Ching Wu, Peng-Yuan Chang, Mei-Yin Yeh, Yi-Hsuan Kuo, Li-Yu Fay, Tsung-Hsi Tu, Wen-Cheng Huang, Henrich Cheng
There are many kinds of artificial discs available for cervical disc arthroplasty (CDA), with various designs of fixation and articulation mechanisms. Each of these designs has different features and theoretically fits most optimally in selected types of patients. However, there has been insufficient literature to guide individualized selection among these CDA devices. Since CDA aims to restore the joint function rather than arthrodesis, tailor-made size, shape, and mechanical properties should be taken into account for each candidate's target disc...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28042722/m6-c-artificial-disc-placement
#13
Domagoj Coric, John Parish, Margaret O Boltes
There has been a steady evolution of cervical total disc replacement (TDR) devices over the last decade resulting in surgical technique that closely mimics anterior cervical discectomy and fusion as well as disc design that emphasizes quality of motion. The M6-C TDR device is a modern-generation artificial disc composed of titanium endplates with tri-keel fixation as well as a polyethylene weave with a polyurethane core. Although not yet approved by the FDA, M6-C has finished a pilot and pivotal US Investigational Device Exemption (IDE) study...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28038739/physicochemical-antioxidant-and-biocompatible-properties-of-chondroitin-sulphate-isolated-from-chicken-keel-bone-for-potential-biomedical-applications
#14
Aruna Rani, Rwivoo Baruah, Arun Goyal
Chicken keel bone cartilage was explored for cheaper and sustainable source for isolation of chondroitin sulphate (CS) for its future use in tissue engineering and pharmaceutical industry. HPSEC analysis displayed two peaks of 100kDa for CS-keel polysaccharide and 1kDa for protein. DLS analysis of CS-keel displayed polydispersity. CS-keel yield was 15% and 53±5% uronic acid content. The quantified percentages of UA-GalNAc4S and UA-GalNAc6S disaccharide in CS-keel were 58% and 42%, respectively. FT-IR identified CS-keel to be chondroitin 4-sulphate...
March 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28003026/a-nurse-led-clinic-for-patients-consulting-with-osteoarthritis-in-general-practice-development-and-impact-of-training-in-a-cluster-randomised-controlled-trial
#15
Emma L Healey, Chris J Main, Sarah Ryan, Gretl A McHugh, Mark Porcheret, Andrew G Finney, Andrew Morden, Krysia S Dziedzic
BACKGROUND: Despite a lack of service provision for people with osteoarthritis (OA), each year 1 in 5 of the general population consults a GP about a musculoskeletal condition such as OA. Consequently this may provide an opportunity for practice nurses to take an active role in helping patients manage their condition. A nurse led clinic for supporting patients with OA was developed for the MOSAICS study investigating how to implement the NICE 2014 OA Guideline core recommendations. This paper has two main objectives, firstly to provide an overview of the nurse-led OA clinic, and secondly to describe the development, key learning objectives, content and impact of the training to support its delivery...
December 21, 2016: BMC Family Practice
https://www.readbyqxmd.com/read/28002660/recovery-from-anorexia-nervosa-and-bulimia-nervosa-at-22-year-follow-up
#16
Kamryn T Eddy, Nassim Tabri, Jennifer J Thomas, Helen B Murray, Aparna Keshaviah, Elizabeth Hastings, Katherine Edkins, Meera Krishna, David B Herzog, Pamela K Keel, Debra L Franko
OBJECTIVE: The course of eating disorders is often protracted, with fewer than half of adults achieving recovery from anorexia nervosa or bulimia nervosa. Some argue for palliative management when duration exceeds a decade, yet outcomes beyond 20 years are rarely described. This study investigates early and long-term recovery in the Massachusetts General Hospital Longitudinal Study of Anorexia and Bulimia Nervosa. METHODS: Females with DSM-III-R/DSM-IV anorexia nervosa or bulimia nervosa were assessed at 9 and at 20 to 25 years of follow-up (mean [SD] = 22...
December 20, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27998816/out-of-southern-africa-origin-biogeography-and-age-of-the-aizooideae-aizoaceae
#17
Cornelia Klak, Pavel Hanáček, Peter V Bruyns
The Aizooideae is an early-diverging lineage within the Aizoaceae. It is most diverse in southern Africa, but also has endemic species in Australasia, Eurasia and South America. We derived a phylogenetic hypothesis from Bayesian and Maximum Likelihood analyses of plastid DNA-sequences. We find that one of the seven genera, the fynbos-endemic Acrosanthes, does not belong to the Aizooideae, but is an ancient sister-lineage to the subfamilies Mesembryanthemoideae & Ruschioideae. Galenia and Plinthus are embedded inside Aizoon and Aizoanthemum is polyphyletic...
December 17, 2016: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/27997542/systematic-approximations-to-susceptible-infectious-susceptible-dynamics-on-networks
#18
Matt J Keeling, Thomas House, Alison J Cooper, Lorenzo Pellis
Network-based infectious disease models have been highly effective in elucidating the role of contact structure in the spread of infection. As such, pair- and neighbourhood-based approximation models have played a key role in linking findings from network simulations to standard (random-mixing) results. Recently, for SIR-type infections (that produce one epidemic in a closed population) on locally tree-like networks, these approximations have been shown to be exact. However, network models are ideally suited for Sexually Transmitted Infections (STIs) due to the greater level of detail available for sexual contact networks, and these diseases often possess SIS-type dynamics...
December 20, 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27997127/pt-mal-lhrh-a-newly-synthesized-compound-attenuating-breast-cancer-tumor-growth-and-metastasis-by-targeting-overexpression-of-the-lhrh-receptor
#19
Lindsay E Calderon, Jonathan K Keeling, Joseph Rollins, Carrie A Black, Kendall Collins, Nova Arnold, Diane E Vance, Margaret W Ndinguri
A new targeting chemotherapeutic agent, Pt-Mal-LHRH, was synthesized by linking activated cisplatin to luteinizing hormone releasing hormone (LHRH). The compound's efficacy and selectivity toward 4T1 breast cancer cells were evaluated. Carboplatin was selected as the comparative platinum complex, since the Pt-Mal-LHRH malonate linker chelates platinum in a similar manner to carboplatin. Breast cancer and normal cell viability were analyzed by an MTT assay comparing Pt-Mal-LHRH with carboplatin. Cells were also treated with either Pt-Mal-LHRH or carboplatin to evaluate platinum uptake by ICP-MS and cell migration using an in vitro scratch-migration assay...
December 20, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27995283/pedicle-screw-augmentation-in-osteoporotic-spine-indications-limitations-and-technical-aspects
#20
S Hoppe, M J B Keel
PURPOSE: The need for spinal instrumented fusion in osteoporotic patients is rising. In this review, we try to give an overview of the current spectrum of pedicle screw augmentation techniques, safety aspects and indications. METHODS: Review of literature and discussion of indications, limitations and technical aspects. RESULTS: Various studies have shown higher failure rates in osteoporotic patients, most probably due to reduced bone quality and a poor bone-screw interface...
December 19, 2016: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
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