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https://www.readbyqxmd.com/read/28331989/does-the-tibia-component-design-affect-the-need-for-offset-stems-in-revision-total-knee-arthroplasty
#1
X Foruria, T Schmidt-Braekling, D Arana Nabarte, M Faschingbauer, M Kasparek, F Boettner
INTRODUCTION: The stem/keel location varies between anatomic and symmetric revision tibial baseplates. The current study investigates the impact of an anatomic versus symmetric stem location on the need for offset couplers in revision total knee arthroplasty. MATERIALS AND METHODS: Hip to ankle standing radiographs and lateral radiographs of 75 patients were analyzed using digital templating software. The offset in the anterior-posterior as well as medial-lateral plane between the center of the tibial diaphysis and the stem of the tibial baseplate were determined for an anatomic and symmetric tibial baseplate, respectively...
March 22, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28328934/proviruses-with-identical-sequences-comprise-a-large-fraction-of-the-replication-competent-hiv-reservoir
#2
John K Bui, Michele D Sobolewski, Brandon F Keele, Jonathan Spindler, Andrew Musick, Ann Wiegand, Brian T Luke, Wei Shao, Stephen H Hughes, John M Coffin, Mary F Kearney, John W Mellors
The major obstacle to curing HIV infection is the persistence of cells with intact proviruses that can produce replication-competent virus. This HIV reservoir is believed to exist primarily in CD4+ T-cells and is stable despite years of suppressive antiretroviral therapy. A potential mechanism for HIV persistence is clonal expansion of infected cells, but how often such clones carry replication-competent proviruses has been controversial. Here, we used single-genome sequencing to probe for identical HIV sequence matches among viruses recovered in different viral outgrowth cultures and between the sequences of outgrowth viruses and proviral or intracellular HIV RNA sequences in uncultured blood mononuclear cells from eight donors on suppressive ART with diverse proviral populations...
March 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28319629/hyperpigmented-papules-and-plaques
#3
Meghan Woody, Brett Keeling, Alde Gavino
No abstract text is available yet for this article.
February 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28318640/the-prevalence-of-diabetic-retinopathy-in-australian-adults-with-self-reported-diabetes-the-national-eye-health-survey
#4
Stuart Keel, Jing Xie, Joshua Foreman, Peter van Wijngaarden, Hugh R Taylor, Mohamed Dirani
PURPOSE: To determine the prevalence of and factors associated with diabetic retinopathy (DR) among non-Indigenous and Indigenous Australian adults with self-reported diabetes. DESIGN: Population-based cross-sectional study. PARTICIPANTS: Non-Indigenous Australians (50-98 years of age) and Indigenous Australians (40-92 years of age) with known diabetes. METHODS: Diabetes was determined based on self-report of previous diagnosis of the disease...
March 15, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28298609/the-impact-of-temperature-changes-on-vector-borne-disease-transmission-culicoides-midges-and-bluetongue-virus
#5
Samuel P C Brand, Matt J Keeling
It is a long recognized fact that climatic variations, especially temperature, affect the life history of biting insects. This is particularly important when considering vector-borne diseases, especially in temperate regions where climatic fluctuations are large. In general, it has been found that most biological processes occur at a faster rate at higher temperatures, although not all processes change in the same manner. This differential response to temperature, often considered as a trade-off between onward transmission and vector life expectancy, leads to the total transmission potential of an infected vector being maximized at intermediate temperatures...
March 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28297354/quantitative-evaluation-of-patient-setup-uncertainty-of-stereotactic-radiotherapy-with-the-frameless-6d-exactrac-system-using-statistical-modeling
#6
Vance Keeling, Sabbir Hossain, Hosang Jin, Ozer Algan, Salahuddin Ahmad, Imad Ali
The purpose of this study is to evaluate patient setup accuracy and quantify individual and cumulative positioning uncertainties associated with different hardware and software components of the stereotactic radiotherapy (SRS/SRT) with the frameless 6D ExacTrac system. A statistical model is used to evaluate positioning uncertainties of the different components of SRS/SRT treatment with the Brainlab 6D ExacTrac system using the positioning shifts of 35 patients having cranial lesions. All these patients are immobilized with rigid head-and-neck masks, simulated with Brainlab localizer and planned with iPlan treatment planning system...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28295150/cause-of-and-factors-associated-with-stillbirth-a-systematic-review-of-classification-systems
#7
Mamuda Aminu, Sarah Bar-Zeev, Nynke van den Broek
INTRODUCTION: An estimated 2.6 million stillbirths occur worldwide each year. A standardised classification system setting out possible cause of death and contributing factors is useful to help obtain comparative data across different settings. We undertook a systematic review of stillbirth classification systems to highlight their strengths and weaknesses for practitioners and policymakers MATERIAL AND METHODS: We conducted a systematic search and review of the literature undertaken to identify classification systems used to aggregate information for stillbirth and perinatal deaths...
March 10, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28287899/retinal-vascular-caliber-and-kidney-function-in-children-and-adolescents-with-type-1-diabetes
#8
Stuart Keel, Catherine Itsiopoulos, Konstandina Koklanis, Meri Vukicevic, Fergus Cameron, Laima Brazionis
PURPOSE: To evaluate the relationship between retinal vascular caliber and kidney function in a cohort of Australian children and adolescents with type 1 diabetes. METHODS: This was a cross-sectional study of 483 children and adolescents with type 1 diabetes, aged 7-18 years. An audit of medical files of participants who attended the Royal Children's Hospital, Melbourne, between January 2009 and March 2014 was performed. Albumin to creatinine ratio (ACR) was acquired through spot urine samples and microalbuminuria was classified as ACR >3...
March 13, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28287760/abstract-feature-codes-the-building-blocks-of-the-implicit-learning-system
#9
Katharina Eberhardt, Sarah Esser, Hilde Haider
According to the Theory of Event Coding (TEC; Hommel, Müsseler, Aschersleben, & Prinz, 2001), action and perception are represented in a shared format in the cognitive system by means of feature codes. In implicit sequence learning research, it is still common to make a conceptual difference between independent motor and perceptual sequences. This supposedly independent learning takes place in encapsulated modules (Keele, Ivry, Mayr, Hazeltine, & Heuer 2003) that process information along single dimensions...
March 13, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28279451/data-driven-models-to-predict-the-elimination-of-sleeping-sickness-in-former-equateur-province-of-drc
#10
K S Rock, A Pandey, M L Ndeffo-Mbah, K E Atkins, C Lumbala, A Galvani, M J Keeling
Approaching disease elimination, it is crucial to be able to assess progress towards key objectives using quantitative tools. For Gambian human African trypanosomiasis (HAT), the ultimate goal is to stop transmission by 2030, while intermediary targets include elimination as a public health problem - defined as <1 new case per 10,000 inhabitants in 90% of foci, and <2000 reported cases by 2020. Using two independent mathematical models, this study assessed the achievability of these goals in the former Equateur province of the Democratic Republic of Congo, which historically had endemic levels of disease...
March 2017: Epidemics
https://www.readbyqxmd.com/read/28274651/translucent-zirconia-in-the-ceramic-scenario-for-monolithic-restorations-a-flexural-strength-and-translucency-comparison-test
#11
Michele Carrabba, Andrew J Keeling, Aziz Aziz, Alessandro Vichi, Riccardo Fabian Fonzar, David Wood, Marco Ferrari
OBJECTIVE: To compare three different compositions of Yttria-Tetragonal Zirconia Polycrystal (Y-TZP) ceramic and a lithium disilicate ceramic in terms of flexural strength and translucency. METHODS: Three zirconia materials of different composition and translucency, Aadva ST [ST], Aadva EI [EI] and Aadva NT [NT](GC Tech, Leuven, Belgium) were cut with a slow speed diamond saw into beams and tabs in order to obtain, after sintering, dimensions of 1.2×4.0×15.0mm and 15...
March 6, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28267607/amalga-like-virus-infecting-antonospora-locustae-a-microsporidian-pathogen-of-grasshoppers-plus-related-viruses-associated-with-other-arthropods
#12
Jesse D Pyle, Patrick J Keeling, Max L Nibert
A previously reported Expressed Sequence Tag (EST) library from spores of microsporidian Antonospora locustae includes a number of clones with sequence similarities to plant amalgaviruses. Reexamining the sequence accessions from that library, we found additional such clones, contributing to a 3247-nt contig that approximates the length of an amalga-like virus genome. Using A. locustae spores stored from that previous study, and new ones obtained from the same source, we newly visualized the putative dsRNA genome of this virus and obtained amplicons yielding a 3387-nt complete genome sequence...
March 3, 2017: Virus Research
https://www.readbyqxmd.com/read/28239654/flow-virometric-sorting-and-analysis-of-hiv-quasispecies-from-plasma
#13
Thomas Musich, Jennifer C Jones, Brandon F Keele, Lisa M Miller Jenkins, Thorsten Demberg, Thomas S Uldrick, Robert Yarchoan, Marjorie Robert-Guroff
Flow cytometry is utilized extensively for cellular analysis, but technical limitations have prevented its routine application for characterizing virus. The recent introduction of nanoscale fluorescence-activated cytometric cell sorting now allows analysis of individual virions. Here, we demonstrate staining and sorting of infectious HIV. Fluorescent antibodies specific for cellular molecules found on budding virions were used to label CCR5-tropic Bal HIV and CXCR4-tropic NL4.3 HIV Env-expressing pseudovirions made in THP-1 cells (monocyte/macrophage) and H9 cells (T cells), respectively...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28222036/vascular-risk-factors-are-associated-with-retinal-arteriolar-narrowing-and-venular-widening-in-children-and-adolescents-with-type-1-diabetes
#14
Stuart Keel, Catherine Itsiopoulos, Konstandina Koklanis, Meri Vukicevic, Fergus Cameron, Laima Brazionis
BACKGROUND: The aim of the study was to describe the relationship of retinal arteriolar and venular calibre with vascular risk factors in children and adolescents with type 1 diabetes. METHODS: In this hospital-based cross-sectional study, the medical files of 483 children and adolescents with type 1 diabetes were audited to collect retinal images and relevant clinical data. Retinal vascular calibre was measured using standardised protocols. RESULTS: After multivariable adjustments, a vascular risk profile that included: older age, higher serum creatinine, higher systolic blood pressure (SBP), higher body mass index (BMI), abnormal estimated glomerular filtration rate (eGFR), lower high-density lipoproteins (HDL) cholesterol, longer duration of diabetes and higher serum sodium was associated with narrower central retinal artery equivalent (CRAE) (95% CI=-4...
March 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28217113/antimicrobial-and-insecticidal-cyclic-lipopeptides-and-hydrogen-cyanide-produced-by-plant-beneficial-pseudomonas-strains-cha0-cmr12a-and-pcl1391-contribute-to-insect-killing
#15
Pascale Flury, Pilar Vesga, Maria Péchy-Tarr, Nora Aellen, Francesca Dennert, Nicolas Hofer, Karent P Kupferschmied, Peter Kupferschmied, Zane Metla, Zongwang Ma, Sandra Siegfried, Sandra de Weert, Guido Bloemberg, Monica Höfte, Christoph J Keel, Monika Maurhofer
Particular groups of plant-beneficial fluorescent pseudomonads are not only root colonizers that provide plant disease suppression, but in addition are able to infect and kill insect larvae. The mechanisms by which the bacteria manage to infest this alternative host, to overcome its immune system, and to ultimately kill the insect are still largely unknown. However, the investigation of the few virulence factors discovered so far, points to a highly multifactorial nature of insecticidal activity. Antimicrobial compounds produced by fluorescent pseudomonads are effective weapons against a vast diversity of organisms such as fungi, oomycetes, nematodes, and protozoa...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28211455/supermode-density-wave-polariton-condensation-with-a-bose-einstein-condensate-in-a-multimode-cavity
#16
Alicia J Kollár, Alexander T Papageorge, Varun D Vaidya, Yudan Guo, Jonathan Keeling, Benjamin L Lev
Phase transitions, where observable properties of a many-body system change discontinuously, can occur in both open and closed systems. By placing cold atoms in optical cavities and inducing strong coupling between light and excitations of the atoms, one can experimentally study phase transitions of open quantum systems. Here we observe and study a non-equilibrium phase transition, the condensation of supermode-density-wave polaritons. These polaritons are formed from a superposition of cavity photon eigenmodes (a supermode), coupled to atomic density waves of a quantum gas...
February 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28207777/quantifying-the-value-of-perfect-information-in-emergency-vaccination-campaigns
#17
Naomi V Bradbury, William J M Probert, Katriona Shea, Michael C Runge, Christopher J Fonnesbeck, Matt J Keeling, Matthew J Ferrari, Michael J Tildesley
Foot-and-mouth disease outbreaks in non-endemic countries can lead to large economic costs and livestock losses but the use of vaccination has been contentious, partly due to uncertainty about emergency FMD vaccination. Value of information methods can be applied to disease outbreak problems such as FMD in order to investigate the performance improvement from resolving uncertainties. Here we calculate the expected value of resolving uncertainty about vaccine efficacy, time delay to immunity after vaccination and daily vaccination capacity for a hypothetical FMD outbreak in the UK...
February 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28186789/meissner-like-effect-for-a-synthetic-gauge-field-in-multimode-cavity-qed
#18
Kyle E Ballantine, Benjamin L Lev, Jonathan Keeling
Previous realizations of synthetic gauge fields for ultracold atoms do not allow the spatial profile of the field to evolve freely. We propose a scheme which overcomes this restriction by using the light in a multimode cavity with many nearly degenerate transverse modes, in conjunction with Raman coupling, to realize an artificial magnetic field which acts on a Bose-Einstein condensate of neutral atoms. We describe the evolution of such a system and present the results of numerical simulations which show dynamical coupling between the effective field and the matter on which it acts...
January 27, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28161240/survival-of-the-pegged-glenoid-component-in-shoulder-arthroplasty-part-ii
#19
Paul B McLendon, Bradley S Schoch, John W Sperling, Joaquin Sanchez-Sotelo, Cathy D Schleck, Robert H Cofield
BACKGROUND: Loosening of the glenoid component is a primary reason for failure of an anatomic shoulder arthroplasty. Pegged glenoids were designed in an effort to outperform keeled components. This study evaluated the midterm clinical and radiographic survival of a single implant design with implantation of an in-line pegged glenoid component and identified risk factors for radiographic loosening and clinical failure. MATERIALS AND METHODS: There were 330 total shoulder arthroplasties that had been implanted with a cemented, all-polyethylene, in-line pegged glenoid component evaluated with an average clinical follow-up of 7...
February 1, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28158985/implementing-the-keele-stratified-care-model-for-patients-with-low-back-pain-an-observational-impact-study
#20
Adrian Bamford, Andy Nation, Susie Durrell, Lazaros Andronis, Ellen Rule, Hugh McLeod
BACKGROUND: The Keele stratified care model for management of low back pain comprises use of the prognostic STarT Back Screening Tool to allocate patients into one of three risk-defined categories leading to associated risk-specific treatment pathways, such that high-risk patients receive enhanced treatment and more sessions than medium- and low-risk patients. The Keele model is associated with economic benefits and is being widely implemented. The objective was to assess the use of the stratified model following its introduction in an acute hospital physiotherapy department setting in Gloucestershire, England...
February 3, 2017: BMC Musculoskeletal Disorders
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