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https://www.readbyqxmd.com/read/28441936/rationale-and-design-of-bistro-a-randomized-controlled-trial-to-determine-whether-bioimpedance-spectroscopy-guided-fluid-management-maintains-residual-kidney-function-in-incident-haemodialysis-patients
#1
Simon J Davies, Fergus J Caskey, David Coyle, Elizabeth Lindley, Jamie Macdonald, Sandip Mitra, Martin Wilkie, Andrew Davenport, Ken Farrington, Indranil Dasgupta, Paula Ormandy, Lazaros Andronis, Ivonne Solis-Trapala, Julius Sim
BACKGROUND: Preserved residual kidney function (RKF) and normal fluid status are associated with better patient outcomes in incident haemodialysis patients. The objective of this trial is to determine whether using bioimpedance technology in prescribing the optimal post-dialysis weight can reduce the rate of decline of RKF and potentially improve patient outcomes. METHODS/DESIGN: 516 pateints commencing haemodialysis, aged >18 with RKF of > 3 ml/min/1...
April 26, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28439405/the-start-back-tool-in-chiropractic-practice-a-narrative-review
#2
REVIEW
Yasmeen Khan
BACKGROUND: The Keele STarT Back Tool was designed for primary care medical physicians in the UK to determine the risk for persistent disabling pain in patients with musculoskeletal pain and to tailor treatments accordingly. In medical and physical therapy settings, STarT Back Tool's tailored care plans improved patients' low back pain outcomes and lowered costs. OBJECTIVE: Review studies using the STarT Back Tool in chiropractic patient populations. METHODS: PubMed, The Cochrane Library, Index to Chiropractic Literature, and Science Direct databases were searched...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/28437185/absence-of-evidence-of-rift-valley-fever-infection-in-eulemur-fulvus-brown-lemur-in-mayotte-during-an-interepidemic-period
#3
Raphaëlle Métras, Laure Dommergues, Katia Ortiz, Marion Pannequin, Christian Schuler, Patrick Roux, John W Edmunds, Matt J Keeling, Catherine Cêtre-Sossah, Eric Cardinale
The potential role of Eulemur fulvus (brown lemur) in the epidemiology of Rift Valley fever (RVF) in Mayotte, during an interepidemic period, was explored. In February and March 2016, 72 animals were blood sampled and tested for RVF. No evidence of RVF genome or antibodies was found in the samples. The role of other wild mammals on the island should, however, be further investigated.
May 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28436084/defining-significant-weight-loss-in-atypical-anorexia-nervosa
#4
K Jean Forney, Tiffany A Brown, Lauren A Holland-Carter, Grace A Kennedy, Pamela K Keel
OBJECTIVE: Atypical anorexia nervosa (AAN) is defined by the symptoms of anorexia nervosa in the presence of "significant weight loss" in individuals who are not underweight. Description of current weight in AAN has been limited, significant weight loss has not been defined, and the distinction between having AAN versus having weight suppression has not been examined. METHOD: Secondary analyses were conducted with data from an epidemiological study of women (n = 1,640) and men (n = 794)...
April 24, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28435864/microbial-arms-race-ballistic-nematocysts-in-dinoflagellates-represent-a-new-extreme-in-organelle-complexity
#5
Gregory S Gavelis, Kevin C Wakeman, Urban Tillmann, Christina Ripken, Satoshi Mitarai, Maria Herranz, Suat Özbek, Thomas Holstein, Patrick J Keeling, Brian S Leander
We examine the origin of harpoon-like secretory organelles (nematocysts) in dinoflagellate protists. These ballistic organelles have been hypothesized to be homologous to similarly complex structures in animals (cnidarians); but we show, using structural, functional, and phylogenomic data, that nematocysts evolved independently in both lineages. We also recorded the first high-resolution videos of nematocyst discharge in dinoflagellates. Unexpectedly, our data suggest that different types of dinoflagellate nematocysts use two fundamentally different types of ballistic mechanisms: one type relies on a single pressurized capsule for propulsion, whereas the other type launches 11 to 15 projectiles from an arrangement similar to a Gatling gun...
March 2017: Science Advances
https://www.readbyqxmd.com/read/28426368/living-in-the-epilepsy-treatment-gap-in-rural-south-india-a-focused-ethnography-of-women-and-problems-associated-with-stigma
#6
Jane R von Gaudecker, Ann Gill Taylor, Arlene W Keeling, Janice M Buelow, Sailas Benjamin
No abstract text is available yet for this article.
April 20, 2017: Health Care for Women International
https://www.readbyqxmd.com/read/28424714/relationships-between-root-pathogen-resistance-abundance-and-expression-of-pseudomonas-antimicrobial-genes-and-soil-properties-in-representative-swiss-agricultural-soils
#7
Nicola Imperiali, Francesca Dennert, Jana Schneider, Titouan Laessle, Christelle Velatta, Marie Fesselet, Michele Wyler, Fabio Mascher, Olga Mavrodi, Dmitri Mavrodi, Monika Maurhofer, Christoph Keel
Strains of Pseudomonas that produce antimicrobial metabolites and control soilborne plant diseases have often been isolated from soils defined as disease-suppressive, i.e., soils, in which specific plant pathogens are present, but plants show no or reduced disease symptoms. Moreover, it is assumed that pseudomonads producing antimicrobial compounds such as 2,4-diacetylphloroglucinol (DAPG) or phenazines (PHZ) contribute to the specific disease resistance of suppressive soils. However, pseudomonads producing antimicrobial metabolites are also present in soils that are conducive to disease...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28422406/comparability-of-three-output-prediction-models-for-a-compact-passively-double-scattered-proton-therapy-system
#8
Sven Ferguson, Yong Chen, Clara Ferreira, Mohammad Islam, Vance P Keeling, Andy Lau, Salahuddin Ahmad, Hosang Jin
The purpose of this study was to investigate comparability of three output prediction models for a compact double-scattered proton therapy system. Two published output prediction models are commissioned for our Mevion S250 proton therapy system. Model A is a correction-based model (Sahoo et al., Med Phys, 2008;35(11):5088-5097) and model B is an analytical model which employs a function of r = (R'-M')/M' (Kooy et al., Phys Med Biol, 2005;50:5487-5456) where R' is defined as depth of distal 100% dose with straggling and M' is the width between distal 100% dose and proximal 100% dose with straggling instead of the theoretical definition due to more accurate output prediction...
April 19, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28412104/cement-stress-predictions-after-anatomic-total-shoulder-arthroplasty-are-correlated-with-preoperative-glenoid-bone-quality
#9
Alexandre Terrier, Raphaël Obrist, Fabio Becce, Alain Farron
HYPOTHESIS: We hypothesized that biomechanical parameters typically associated with glenoid implant failure after anatomic total shoulder arthroplasty (aTSA) would be correlated with preoperative glenoid bone quality. METHODS: We developed an objective automated method to quantify preoperative glenoid bone quality in different volumes of interest (VOIs): cortical bone, subchondral cortical plate, subchondral bone after reaming, subchondral trabecular bone, and successive layers of trabecular bone...
April 12, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28411039/the-prevalence-of-self-reported-stroke-in-the-australian-national-eye-health-survey
#10
Stuart Keel, Joshua Foreman, Jing Xie, Hugh R Taylor, Mohamed Dirani
BACKGROUND AND PURPOSE: The study aimed to determine the prevalence of and risk factors for self-reported stroke in Indigenous and non-Indigenous Australians. RESEARCH DESIGN AND METHODS: In this national eye study, 1738 Indigenous Australians (41.1% male) aged 40-92 years and 3098 non-Indigenous Australians (46.4% male) aged 50-98 years from 30 randomly selected sites, stratified by remoteness, were recruited and examined. Sociodemographic information and a history of stroke, diabetes, and ocular health were obtained using an interviewer-administered questionnaire...
April 11, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28407009/treatment-coverage-rates-for-refractive-error-in-the-national-eye-health-survey
#11
Joshua Foreman, Jing Xie, Stuart Keel, Hugh R Taylor, Mohamed Dirani
OBJECTIVE: To present treatment coverage rates and risk factors associated with uncorrected refractive error in Australia. METHODS: Thirty population clusters were randomly selected from all geographic remoteness strata in Australia to provide samples of 1738 Indigenous Australians aged 40 years and older and 3098 non-Indigenous Australians aged 50 years and older. Presenting visual acuity was measured and those with vision loss (worse than 6/12) underwent pinhole testing and hand-held auto-refraction...
2017: PloS One
https://www.readbyqxmd.com/read/28390460/dental-emergency-practice-characteristics-among-north-carolina-pediatric-and-general-dentists
#12
Erica A Brecher, Martha Ann Keels, Rocio B Quiñonez, Michael W Roberts, William Clay Bordley
PURPOSE: The purpose of this study was to assess after-hours practice characteristics of pediatric dentists (PDs) and general dentists (GDs) and determine how patients-of-record obtain after-hours emergency dental care. METHODS: A 29-item survey was electronically distributed to PDs and GDs in North Carolina in September 2014. Demographics and after-hours emergency practice characteristics were assessed. Survey respondents were subsequently called after-hours to validate reported after-hours emergency protocol...
March 15, 2017: Pediatric Dentistry
https://www.readbyqxmd.com/read/28388206/suppressing-and-restoring-the-dicke-superradiance-transition-by-dephasing-and-decay
#13
Peter Kirton, Jonathan Keeling
We show that dephasing of individual atoms destroys the superradiance transition of the Dicke model, but that adding individual decay toward the spin down state can restore this transition. To demonstrate this, we present a method to give an exact solution for the N atom problem with individual dephasing which scales polynomially with N. By comparing finite size scaling of our exact solution to a cumulant expansion, we confirm the destruction and restoration of the superradiance transition hold in the thermodynamic limit...
March 24, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28385941/patients-undergoing-surgical-hip-dislocation-for-the-treatment-of-acetabular-fractures-show-favourable-long-term-outcome
#14
P C Haefeli, G S Marecek, M J B Keel, K A Siebenrock, M Tannast
AIMS: The aims of this study were to determine the cumulative ten-year survivorship of hips treated for acetabular fractures using surgical hip dislocation and to identify factors predictive of an unfavourable outcome. PATIENTS AND METHODS: We followed up 60 consecutive patients (61 hips; mean age 36.3 years, standard deviation (sd) 15) who underwent open reduction and internal fixation for a displaced fracture of the acetabulum (24 posterior wall, 18 transverse and posterior wall, ten transverse, and nine others) with a mean follow-up of 12...
April 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28385615/identification-and-characterisation-of-a-salt-form-of-danirixin-with-reduced-pharmacokinetic-variability-in-patient-populations
#15
Jackie C Bloomer, Claire Ambery, Bruce E Miller, Paul Connolly, Helen Garden, Nick Henley, Neil Hodnett, Sarah Keel, James L Kreindler, Richard S Lloyd, Wayne Matthews, John Yonchuk, Aili L Lazaar
The natural variability of gastric pH or gastric acid reducing medications can result in lower and more variable clinical pharmacokinetics for basic compounds in patient populations. Progressing alternative salt forms with improved solubility and dissolution properties can minimise this concern. This manuscript outlines a nonclinical approach comprising multiple biopharmaceutical, in vitro and physiologically based pharmacokinetic model (PBPK) modelling studies to enable selection of an alternative salt form for danirixin (DNX, GSK1325756), a pharmaceutical agent being developed for chronic obstructive pulmonary disease (COPD)...
April 3, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28381583/the-sensitivity-argument-against-child-euthanasia
#16
Geoff Keeling
Is there a moral difference between euthanasia for terminally ill adults and euthanasia for terminally ill children? Luc Bovens considers five arguments to this effect, and argues that each is unsuccessful. In this paper, I argue that Bovens' dismissal of the sensitivity argument is unconvincing.
April 5, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28379533/opportunities-for-exercise-during-pullet-rearing-part-i-effect-on-the-musculoskeletal-characteristics-of-pullets
#17
T M Casey-Trott, D R Korver, M T Guerin, V Sandilands, S Torrey, T M Widowski
Increased load-bearing exercise improves bone quality characteristics in a variety of species, including laying hens. Providing increased opportunities for exercise during the pullet rearing phase, a period of substantial musculoskeletal growth, offers a proactive approach to reducing osteoporosis by improving bone composition. The main objective of this study was to determine whether differing opportunities for exercise during rearing influences pullet musculoskeletal characteristics. Two flock replicates of 588 Lohmann Selected Leghorn-Lite pullets were reared in either standard, conventional cages (Conv) or an aviary rearing system (Avi) from day-old chicks until 16 wk of age...
March 31, 2017: Poultry Science
https://www.readbyqxmd.com/read/28376091/participant-referral-rate-in-the-national-eye-health-survey-nehs
#18
Stuart Keel, Pei Ying Lee, Joshua Foreman, Peter van Wijngaarden, Hugh R Taylor, Mohamed Dirani
PURPOSE: To present the rates of referral of participants in the National Eye Health Survey (NEHS) for further eye care. MATERIALS & METHODS: A national sample of 3098 non-Indigenous Australians aged 50-98 and 1738 Indigenous Australians aged 40-92 years living in 30 randomly selected sites was recruited using a door-to-door approach. Participants completed a general questionnaire and a series of eye tests, including vision and anterior segment assessment, intra-ocular pressure measurement, visual field testing and fundus photography...
2017: PloS One
https://www.readbyqxmd.com/read/28371938/rearing-system-affects-prevalence-of-keel-bone-damage-in-laying-hens-a-longitudinal-study-of-four-consecutive-flocks
#19
T M Casey-Trott, M T Guerin, V Sandilands, S Torrey, T M Widowski
High flock-level prevalence of keel-bone fractures and deviations in laying hens are commonly reported across various housing systems; however, few longitudinal studies exist, especially for furnished and conventional cage systems. Load-bearing exercise improves bone strength and mineral composition in laying hens and has the potential to reduce keel-bone damage, especially if exercise is allowed during critical periods of bone growth throughout the pullet rearing phase. The objective of this study was to determine the prevalence of keel-bone damage in laying hens housed in furnished and conventional cages, and assess whether opportunities for exercise during the pullet rearing phase influenced the prevalence of keel-bone damage throughout the laying period...
March 21, 2017: Poultry Science
https://www.readbyqxmd.com/read/28368478/stabilization-of-tumor-associated-craniovertebral-junction-instability-indications-operative-variables-and-outcomes
#20
Scott L Zuckerman, Fabiana Kreines, Ann Powers, J Bryan Iorgulescu, James B Elder, Mark H Bilsky, Ilya Laufer
BACKGROUND: Whether primary or metastatic, tumors of the craniovertebral junction (CVJ) are rare and challenging. OBJECTIVE: To examine the surgical indications, operative variables, and outcomes in patients with tumors of the CVJ undergoing occipitocervical (OC) stabilization. METHODS: A single-institution, retrospective case series was performed from a prospectively maintained spine database. Patients with primary or metastatic tumors of the CVJ who underwent OC stabilization were identified...
March 28, 2017: Neurosurgery
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