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https://www.readbyqxmd.com/read/29163597/morphology-carbohydrate-distribution-gene-expression-and-enzymatic-activities-related-to-cell-wall-hydrolysis-in-four-barley-varieties-during-simulated-malting
#1
Natalie S Betts, Laura G Wilkinson, Shi F Khor, Neil J Shirley, Finn Lok, Birgitte Skadhauge, Rachel A Burton, Geoffrey B Fincher, Helen M Collins
Many biological processes, such as cell wall hydrolysis and the mobilisation of nutrient reserves from the starchy endosperm, require stringent regulation to successfully malt barley (Hordeum vulgare) grain in an industrial context. Much of the accumulated knowledge defining these events has been collected from individual, unrelated experiments, and data have often been extrapolated from Petri dish germination, rather than malting, experiments. Here, we present comprehensive morphological, biochemical, and transcript data from a simulated malt batch of the three elite malting cultivars Admiral, Navigator, and Flagship, and the feed cultivar Keel...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29163562/combined-field-inoculations-of-pseudomonas-bacteria-arbuscular-mycorrhizal-fungi-and-entomopathogenic-nematodes-and-their-effects-on-wheat-performance
#2
Nicola Imperiali, Xavier Chiriboga, Klaus Schlaeppi, Marie Fesselet, Daniela Villacrés, Geoffrey Jaffuel, S Franz Bender, Francesca Dennert, Ruben Blanco-Pérez, Marcel G A van der Heijden, Monika Maurhofer, Fabio Mascher, Ted C J Turlings, Christoph J Keel, Raquel Campos-Herrera
In agricultural ecosystems, pest insects, pathogens, and reduced soil fertility pose major challenges to crop productivity and are responsible for significant yield losses worldwide. Management of belowground pests and diseases remains particularly challenging due to the complex nature of the soil and the limited reach of conventional agrochemicals. Boosting the presence of beneficial rhizosphere organisms is a potentially sustainable alternative and may help to optimize crop health and productivity. Field application of single beneficial soil organisms has shown satisfactory results under optimal conditions...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29150856/defining-sepsis-on-the-wards-results-of-a-multi-centre-point-prevalence-study-comparing-two-sepsis-definitions
#3
T Szakmany, R Pugh, M Kopczynska, R M Lundin, B Sharif, P Morgan, G Ellis, J Abreu, S Kulikouskaya, K Bashir, L Galloway, H Al-Hassan, T Grother, P McNulty, S T Seal, A Cains, M Vreugdenhil, M Abdimalik, N Dennehey, G Evans, J Whitaker, E Beasant, C Hall, M Lazarou, C V Vanderpump, K Harding, L Duffy, A Guerrier Sadler, R Keeling, C Banks, S W Y Ng, S Y Heng, D Thomas, E W Puw, I Otahal, C Battle, O Minik, R A Lyons, J E Hall
Our aim was to prospectively determine the predictive capabilities of SEPSIS-1 and SEPSIS-3 definitions in the emergency departments and general wards. Patients with National Early Warning Score (NEWS) of 3 or above and suspected or proven infection were enrolled over a 24-h period in 13 Welsh hospitals. The primary outcome measure was mortality within 30 days. Out of the 5422 patients screened, 431 fulfilled inclusion criteria and 380 (88%) were recruited. Using the SEPSIS-1 definition, 212 patients had sepsis...
November 17, 2017: Anaesthesia
https://www.readbyqxmd.com/read/29147834/topical-collection-the-epds-thirty-years-on-special-guest-editor-john-cox-professor-emeritus-keele-university-uk-bm-bch-dm-oxon-frcpsyh-frcp-23-new-court-lnsdown-rd-cheltenham-gl50-2-jg
#4
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29146713/autonomy-nudging-and-post-truth-politics
#5
Geoff Keeling
In his excellent essay, 'Nudges in a post-truth world', Neil Levy argues that 'nudges to reason', or nudges which aim to make us more receptive to evidence, are morally permissible. A strong argument against the moral permissibility of nudging is that nudges fail to respect the autonomy of the individuals affected by them. Levy argues that nudges to reason do respect individual autonomy, such that the standard autonomy objection fails against nudges to reason. In this paper, I argue that Levy fails to show that nudges to reason respect individual autonomy...
November 16, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29134633/first-in-human-study-with-the-inhaled-tlr9-oligonucleotide-agonist-azd1419-results-in-interferon-responses-in-the-lung-and-is-safe-and-well-tolerated
#6
Sam Jackson, Albert F Candia, Stephen Delaney, Simone Floettmann, Clifford Wong, John D Campbell, Sariah Kell, Jeremy Lum, Edith Hessel, Paula Traquina, Mark McHale, Ian Robinson, John Bell, Rainard Fuhr, David Keeling, Robert L Coffman
Current asthma treatments address symptoms rather than the underlying disease pathophysiology, a better understanding of which has led to the identification of the Th2 high endotype. The activation of Toll-like receptors to induce Type I interferons directly in the lungs represents a novel therapeutic approach to reset this underlying Th2 pathophysiology with the potential to provide long-term disease modification. We present the nonclinical data and phase 1 clinical profile of an inhaled TLR9 agonist, AZD1419, a C-type CpG designed to induce interferon in the lung...
November 14, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29129115/innovative-layer-genetics-to-handle-global-challenges-in-egg-production
#7
R Preisinger
1. In commercial layer breeding, extensive gene pools are tested and selected for market requirements which must be anticipated at least five years ahead. Field results confirm a continuous positive genetic trend in egg output and better feed efficiency which can be converted into land savings. 2. Animal welfare and cage-free housing dominate future needs of the market. Nesting behaviour and minimal tendency to develop feather-pecking or cannibalism without beak treatment, are key trait complexes. Stronger shells for longer production cycles without moulting have to be combined with better bones...
November 13, 2017: British Poultry Science
https://www.readbyqxmd.com/read/29124859/sympatric-kelp-species-share-a-large-portion-of-their-surface-bacterial-communities
#8
Matthew A Lemay, Patrick T Martone, Patrick Keeling, Jenn M Burt, Kira A Krumhansl, Rhea D Sanders, Laura Wegener Parfrey
Kelp forest ecosystems are biodiversity hotspots, providing habitat for dense assemblages of marine organisms and nutrients for marine and terrestrial food webs. The surfaces of kelps support diverse microbial communities that facilitate the transfer of carbon from algal primary production to higher trophic levels. We quantified the diversity of bacteria on the surfaces of eight sympatric kelp species from four sites in British Columbia. Kelp-associated bacterial communities are significantly different from their environment, even though 86% of their bacterial taxa are shared with seawater and 97% are shared with rocky substrate...
November 10, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/29122671/temporal-cytokine-and-lymphoid-responses-to-an-inhaled-tlr7-antedrug-agonist-in-the-cynomolgus-monkey-demonstrates-potential-safety-and-tolerability-of-this-approach
#9
John Bell, Mike Dymond, Mark Biffen, Stephen Delaney, David Keeling, Hui Zhang, Ian Robinson
AZD8848 is a TLR7 agonist antedrug developed for administration by inhalation dosing for the treatment of allergic diseases, such as asthma. Allergic asthma is associated with increased levels of Th2 cytokines which are suppressed for extended periods by TLR7 agonists in a number of preclinical models of allergic airway inflammation. However, TLRs form a central part of innate immunity and their activation often results in proinflammatory responses. Whilst AZD8848's antedrug mechanism is designed to restrict its pharmacological action beyond the lung, the effect of chronic, supramaximal dosing to the target tissue has yet to be defined...
November 6, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29121468/effect-of-extended-benzannelation-orientation-on-bergman-and-related-cyclizations-of-isomeric-quinoxalenediynes
#10
Stephanie A Valenzuela, Alondra J Cortés, Zakery J E Tippins, Morgan H Daly, Terell E Keel, Benjamin F Gherman, John D Spence
A combined computational and experimental study was conducted to examine the effect of extended benzannelation orientation on C(1)-C(5) and C(1)-C(6) cyclization of acyclic quinoxalenediynes. Calculations (mPW1PW91/cc-pVTZ//mPW1PW91/6-31G(d,p)) on terminal and phenylethynyl-substituted 5,6-diethynylquinoxaline and 6,7-diethynylquinoxaline showed C(1)-C(6) Bergman cyclization as the favored thermodynamic reaction pathway, with larger C(1)-C(6) preference for the angular quinoxalenediynes due to gain of a new aromatic sextet...
November 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29118123/estimating-initial-viral-levels-during-hiv-siv-reactivation-from-latency
#11
Mykola Pinkevych, Christine M Fennessey, Deborah Cromer, Martin Tolstrup, Ole S Søgaard, Thomas A Rasmussen, Brandon F Keele, Miles P Davenport
HIV viremia rebounds rapidly after treatment interruption, and a variety of strategies are being explored to reduce or control viral reactivation post-treatment. This viral rebound arises from reactivation of individual latently infected cells, which spread during ongoing rounds of productive infection. The level of virus produced by the initial individual reactivating cells is not known, although it may have major implications for the ability of different immune interventions to control viral rebound. Here we use data from both HIV and SIV treatment interruption studies to estimate the initial viral load post-interruption and thereby the initial individual reactivation event...
November 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29112882/age-related-patterns-in-work-related-injury-claims-from-older-new-zealanders-2009-2013-implications-of-injury-for-an-aging-workforce
#12
Rebbecca Lilley, Chrystal Jaye, Gabrielle Davie, Sally Keeling, Debra Waters, Richard Egan
OBJECTIVES: This study describes the incidence, nature and cause of work-related injuries in older New Zealand workers to understand the risks of work-related injury in this rapidly aging population. METHODS: Data for the period 2009-2013 from 25,455 injured workers aged 55-79 years, extracted from national work-related injury entitlement claims, were stratified by age group and analysed by sex, industry, injury type and cause. Age-specific claims rates were calculated by year, sex and ethnicity...
November 4, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29108031/beef-steers-with-average-dry-matter-intake-and-divergent-average-daily-gain-have-altered-gene-expression-in-the-jejunum
#13
A P Foote, B N Keel, C M Zarek, A K Lindholm-Perry
The objective of this study was to determine the association of differentially expressed genes (DEG) in the jejunum of steers with average DMI and high or low ADG. Feed intake and growth were measured in a cohort of 144 commercial Angus steers consuming a finishing diet containing (on a DM basis) 67.8% dry-rolled corn, 20% wet distillers grains with solubles, 8% alfalfa hay, and 4.2% vitamin/mineral supplement. From the cohort, a subset of steers with DMI within ±0.32 SD of the mean for DMI and the greatest (high) and least (low) ADG were chosen for slaughter and jejunum mucosa collection ( = 8 for each group)...
October 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/29105532/early-aseptic-loosening-of-a-mobile-bearing-total-knee-replacement
#14
Ines Kutzner, Geir Hallan, Paul Johan Høl, Ove Furnes, Øystein Gøthesen, Wender Figved, Peter Ellison
Background and purpose - Registry-based studies have reported an increased risk of aseptic tibial loosening for the cemented Low Contact Stress (LCS) total knee replacement compared with other cemented designs; however, the reasons for this have not been established. We made a retrieval analysis with the aim of identifying the failure mechanism. Patients and methods - We collected implants, cement, tissue, blood, and radiographs from 32 failed LCS Complete cases. Damage to the tibial baseplate and insert was assessed...
November 6, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/29105489/effect-of-different-periods-of-chronic-heat-stress-with-or-without-vitamin-c-supplementation-on-bone-and-selected-serum-parameters-of-broilers
#15
Najmeh Mosleh, Tahoora Shomali, Fahimeh Nematollahi, Zahra Ghahramani, Mohammad Saeid Ahrari Khafi, Fatemeh Namazi
This study evaluates the effect of different periods of chronic heat stress (CHS) on selected bone and serum parameters of broilers with or without vitamin C administration. Ninety 23 day old-chickens were randomly allocated into 7 groups: 1. control, 2. short term CHS (5 days), 3. short term CHS + vitamin C (12 g/100L drinking water of a 50% product) 4. medium term CHS (10 days), 5. medium term CHS + vitamin C, 6. long term CHS (20 days) and 7. long term CHS + vitamin C. In heat stressed groups the temperature was increased to 39±1°C for 8h/day...
November 6, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/29078155/predictors-of-long-term-recovery-in-anorexia-nervosa-and-bulimia-nervosa-data-from-a-22-year-longitudinal-study
#16
Debra L Franko, Nassim Tabri, Aparna Keshaviah, Helen B Murray, David B Herzog, Jennifer J Thomas, Kathryn Coniglio, Pamela K Keel, Kamryn T Eddy
OBJECTIVE: The objective of this study was to investigate predictors of long-term recovery from eating disorders 22 years after entry into a longitudinal study. METHOD: One hundred and seventy-six of the 228 surviving participants (77.2%) were re-interviewed 20-25 years after study entry using the Longitudinal Interval Follow-up Evaluation to assess ED recovery. The sample consisted of 100 women diagnosed with anorexia nervosa (AN) and 76 with bulimia nervosa (BN) at study entry...
October 16, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29072274/evidence-of-marine-ice-cliff-instability-in-pine-island-bay-from-iceberg-keel-plough-marks
#17
Matthew G Wise, Julian A Dowdeswell, Martin Jakobsson, Robert D Larter
Marine ice-cliff instability (MICI) processes could accelerate future retreat of the Antarctic Ice Sheet if ice shelves that buttress grounding lines more than 800 metres below sea level are lost. The present-day grounding zones of the Pine Island and Thwaites glaciers in West Antarctica need to retreat only short distances before they reach extensive retrograde slopes. When grounding zones of glaciers retreat onto such slopes, theoretical considerations and modelling results indicate that the retreat becomes unstable (marine ice-sheet instability) and thus accelerates...
October 25, 2017: Nature
https://www.readbyqxmd.com/read/29055089/the-importance-and-requirement-of-belowground-carbon-inputs-for-robust-estimation-of-soil-organic-carbon-dynamics-reply-to-keel-et%C3%A2-al-2017
#18
Zhongkui Luo, Enli Wang, Wenting Feng, Yiqi Luo, Jeff Baldock
In a recent paper, we assessed the legacy data reported by Skjemstad and Spouncer (2003) and found that the amount of aboveground carbon (C) input (i.e., crop residues) in Australian cropping systems was the most important factor affecting soil C change among all the assessed drivers including the quantity and quality of C inputs, climate and soil properties (Luo et al., 2017). Keel et al. (2017) argued that the C input data used in our study "may have led to important biases and critical omissions", due to: 1) ignorance of belowground C inputs from roots/rhizodeposition, and 2) use of a constant harvest index (HI) for crops...
October 20, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29054822/determining-the-effects-of-pei-adsorption-on-the-permeability-of-dppc-bmp-membranes-under-osmotic-stress
#19
Scott R Clark, Keel Yong Lee, Hoyoung Lee, Jawahar Khetan, Hyun Chang Kim, Yun Hwa Choi, Kwanwoo Shin, You-Yeon Won
Polycations are used for a number of biological applications, including antibiotics and gene therapy. One aspect of the use of polycation gene carriers such as polyethylenemine (PEI) in gene therapy that is not well understood is their ability to escape from the vesicles they are internalized in. Here, in an attempt to gain a better understanding of PEI interaction with endosomal lipids under osmotic stress, we performed investigations using monolayers and vesicles derived from a mixture of neutral and negative lipids (1,2-dipalmitoylphosphatidylcholine (DPPC) and bis(monoacylglycero)phosphate (BMP), respectively)...
October 17, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29051885/the-reversed-less-invasive-stabilisation-system-distal-femur-technique-application-in-an-adult-patient-with-osteogenesis-imperfecta-sustaining-a-femoral-fracture
#20
Markus S Hanke, Marius Johann Keel, Inga A Todorski, Johannes Dominik Bastian
INTRODUCTION: The aim of this study was to report the surgical management and to discuss the options for fracture fixation in an adult patient with osteogenesis imperfecta (OI) who sustained a trochanteric femoral fracture after a simple fall from standing position. CASE REPORT: As a result of multiple fractures during childhood, this adult patient with OI presented with a short stature. The radiographs revealed a displaced, intertrochanteric fracture with subtrochanteric extension of the left femur...
May 2017: Journal of Orthopaedic Case Reports
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