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https://www.readbyqxmd.com/read/28918112/radiographic-and-clinical-comparison-of-pegged-and-keeled-glenoid-components-using-modern-cementing-techniques-midterm-results-of-a-prospective-randomized-study
#1
Christopher M Kilian, Cyrus M Press, Kevin M Smith, Daniel P O'Connor, Brent J Morris, Hussein A Elkousy, Gary M Gartsman, T Bradley Edwards
BACKGROUND: Glenoid component loosening remains a significant issue after anatomic shoulder arthroplasty. Pegged glenoid components have shown better lucency rates than keeled components in the short term; however, midterm to long-term results have not fully been determined. We previously reported early outcomes of the current randomized controlled group of patients, with higher glenoid lucency rates in those with a keeled glenoid. The purpose of this study was to evaluate the radiographic and clinical outcomes of these components at minimum 5-year follow-up...
September 13, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28914269/looking-beyond-the-exome-a-phenotype-first-approach-to-molecular-diagnostic-resolution-in-rare-and-undiagnosed-diseases
#2
Loren D M Pena, Yong-Hui Jiang, Kelly Schoch, Rebecca C Spillmann, Nicole Walley, Nicholas Stong, Sarah Rapisardo Horn, Jennifer A Sullivan, Allyn McConkie-Rosell, Sujay Kansagra, Edward C Smith, Mays El-Dairi, Jane Bellet, Martha Ann Keels, Joan Jasien, Peter G Kranz, Richard Noel, Shashi K Nagaraj, Robert K Lark, Daniel S G Wechsler, Daniela Del Gaudio, Marco L Leung, Laura G Hendon, Collette C Parker, Kelly L Jones, David B Goldstein, Vandana Shashi
PurposeTo describe examples of missed pathogenic variants on whole-exome sequencing (WES) and the importance of deep phenotyping for further diagnostic testing.MethodsGuided by phenotypic information, three children with negative WES underwent targeted single-gene testing.ResultsIndividual 1 had a clinical diagnosis consistent with infantile systemic hyalinosis, although WES and a next-generation sequencing (NGS)-based ANTXR2 test were negative. Sanger sequencing of ANTXR2 revealed a homozygous single base pair insertion, previously missed by the WES variant caller software...
September 14, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28904195/vector-order-determines-protection-against-pathogenic-simian-immunodeficiency-virus-infection-in-a-triple-component-vaccine-by-balancing-cd4-and-cd8-t-cell-responses
#3
Ulrike Sauermann, Antonia Radaelli, Nicole Stolte-Leeb, Katharina Raue, Massimiliano Bissa, Carlo Zanotto, Michael Krawczak, Matthias Tenbusch, Klaus Überla, Brandon F Keele, Carlo De Giuli Morghen, Sieghart Sopper, Christiane Stahl-Hennig
An effective AIDS vaccine should elicit strong humoral and cellular immune responses while maintaining low levels of CD4(+) T cell activation to avoid the generation of target cells for viral infection. The present study investigated two prime-boost regimens, both starting vaccination with single cycle immunodeficiency virus, followed by two mucosal boosts either with recombinant adenovirus (rAd) or fowlpox virus (rFWPV) expressing SIVmac239 or SIVmac251 gag/pol and env genes, respectively. Finally, vectors were switched and systemically administered to the reciprocal group of animals...
September 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28899557/can-the-recovery-of-lower-limb-fractures-be-achieved-by-use-of-3d-printing-mirror-model
#4
Wenxi Zhang, Yueping Ji, Xinming Wang, Jie Liu, Dong Li
INTRODUCTION: The mirror imaging 3D printing model can be used a as a reference for anatomical reduction in unilateral lower limb fractures. However, the premise of using mirror technology is that the bilateral lower limb bones are similar enough. Because one side had a fracture, it was impossible to compare this directly to the other side. Usually, surgeons think that the bilateral bones are symmetrical and use mirror technology without judging their symmetry. METHODS: In patients with a unilateral lower limb bone fracture, we measured the long axis and short axis of the three selected transverse sections of the bilateral long bone for comparison to judge the symmetry of the bilateral long bones on CT images...
September 6, 2017: Injury
https://www.readbyqxmd.com/read/28899329/cataract-surgery-coverage-rates-for-indigenous-and-non-indigenous-australians-the-national-eye-health-survey
#5
Joshua Foreman, Jing Xie, Stuart Keel, Peter van Wijngaarden, Jonathan Crowston, Hugh R Taylor, Mohamed Dirani
OBJECTIVE: To determine cataract surgery coverage rates for Indigenous and non-Indigenous Australians. DESIGN: National cross-sectional population-based survey. SETTING: Thirty randomly selected Australian geographic sites, stratified by remoteness. PARTICIPANTS: 3098 non-Indigenous Australians aged 50 years or more and 1738 Indigenous Australians aged 40 years or more, recruited and examined in the National Eye Health Survey (NEHS) between March 2015 and April 2016...
September 18, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28893986/atmospheric-evidence-for-a-global-secular-increase-in-carbon-isotopic-discrimination-of-land-photosynthesis
#6
Ralph F Keeling, Heather D Graven, Lisa R Welp, Laure Resplandy, Jian Bi, Stephen C Piper, Ying Sun, Alane Bollenbacher, Harro A J Meijer
A decrease in the (13)C/(12)C ratio of atmospheric CO2 has been documented by direct observations since 1978 and from ice core measurements since the industrial revolution. This decrease, known as the (13)C-Suess effect, is driven primarily by the input of fossil fuel-derived CO2 but is also sensitive to land and ocean carbon cycling and uptake. Using updated records, we show that no plausible combination of sources and sinks of CO2 from fossil fuel, land, and oceans can explain the observed (13)C-Suess effect unless an increase has occurred in the (13)C/(12)C isotopic discrimination of land photosynthesis...
September 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28878010/broadly-neutralizing-antibodies-targeting-the-hiv-1-envelope-v2-apex-confer-protection-against-a-clade-c-shiv-challenge
#7
Boris Julg, Lawrence J Tartaglia, Brandon F Keele, Kshitij Wagh, Amarendra Pegu, Devin Sok, Peter Abbink, Stephen D Schmidt, Keyun Wang, Xuejun Chen, M Gordon Joyce, Ivelin S Georgiev, Misook Choe, Peter D Kwong, Nicole A Doria-Rose, Khoa Le, Mark K Louder, Robert T Bailer, Penny L Moore, Bette Korber, Michael S Seaman, Salim S Abdool Karim, Lynn Morris, Richard A Koup, John R Mascola, Dennis R Burton, Dan H Barouch
Neutralizing antibodies to the V2 apex antigenic region of the HIV-1 envelope (Env) trimer are among the most prevalent cross-reactive antibodies elicited by natural infection. Two recently described V2-specific antibodies, PGDM1400 and CAP256-VRC26.25, have demonstrated exquisite potency and neutralization breadth against HIV-1. However, little data exist on the protective efficacy of V2-specific neutralizing antibodies. We created a novel SHIV-325c viral stock that included a clade C HIV-1 envelope and was susceptible to neutralization by both of these antibodies...
September 6, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28859745/cutaneous-rosai-dorfman-disease
#8
Brett H Keeling, Lindsay LaPresto Thelin, A Carlo Gavino, Ammar M Ahmed
A 48-year-old Hispanic man presented with a nodule on the right cheek. The lesion had started as a papule 4 months previously that had slowly enlarged and then plateaued at its present size. The nodule was asymptomatic, and the patient denied bleeding, draining, or preceding trauma. Review of systems was negative for fevers, weight loss, night sweats, lymphadenopathy, or other skin findings. Past medical history was significant only for type 2 diabetes mellitus, hyperlipidemia, and hypertension.
2017: Skinmed
https://www.readbyqxmd.com/read/28857390/challenges-in-measuring-the-effects-of-pharmacological-interventions-on-cognitive-and-adaptive-functioning-in-individuals-with-down-syndrome-a-systematic-review
#9
REVIEW
Lori A Keeling, Gail A Spiridigliozzi, Sarah J Hart, Jane A Baker, Harrison N Jones, Priya S Kishnani
We systematically reviewed the measures used in pharmaceutical trials in children/adults with Down syndrome without dementia. Our purpose was to identify developmentally appropriate outcome measures capable of detecting changes in cognitive and adaptive functioning in this population. Eleven studies were included and used diverse outcome measures across the domains of language, memory, attention, behavior, and executive/adaptive functioning. Our results highlight the challenges in selecting measures capable of capturing improvements in pharmaceutical trials in individuals with DS...
August 31, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28840814/molecular-characterization-and-phylogeny-of-four-new-species-of-the-genus-trichonympha-parabasalia-trichonymphea-from-lower-termite-hindguts
#10
Vittorio Boscaro, Erick R James, Rebecca Fiorito, Elisabeth Hehenberger, Anna Karnkowska, Javier Del Campo, Martin Kolisko, Nicholas A T Irwin, Varsha Mathur, Rudolf H Scheffrahn, Patrick J Keeling
Members of the genus Trichonympha are among the most well-known, recognizable and widely distributed parabasalian symbionts of lower termites and the wood-eating cockroach species of the genus Cryptocercus. Nevertheless, the species diversity of this genus is largely unknown. Molecular data have shown that the superficial morphological similarities traditionally used to identify species are inadequate, and have challenged the view that the same species of the genus Trichonympha can occur in many different host species...
August 25, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28828243/microbial-communities-in-the-reef-water-at-kham-island-lower-gulf-of-thailand
#11
Naraporn Somboonna, Alisa Wilantho, Somchai Monanunsap, Suchana Chavanich, Sithichoke Tangphatsornruang, Sissades Tongsima
Coral reefs are among the most biodiverse habitats on Earth, but knowledge of their associated marinemicrobiome remains limited. To increase the understanding of the coral reef ecosystem in the lower Gulf of Thailand, this study utilized 16S and 18S rRNA gene-based pyrosequencing to identify the prokaryotic and eukaryotic microbiota present in the reef water at Kham Island, Trat province, Thailand (N6.97 E100.86). The obtained result was then compared with the published microbiota from different coral reef water and marine sites...
2017: PeerJ
https://www.readbyqxmd.com/read/28821861/the-validity-of-self-report-of-eye-diseases-in-participants-with-vision-loss-in-the-national-eye-health-survey
#12
Joshua Foreman, Jing Xie, Stuart Keel, Peter van Wijngaarden, Hugh R Taylor, Mohamed Dirani
We assessed the validity and reliability of self-report of eye disease in participants with unilateral vision loss (presenting visual acuity worse than 6/12 in the worse eye and equal to or better than 6/12 in the better eye) or bilateral vision loss (presenting visual acuity worse than 6/12 in the better eye) in Australia's National Eye Health Survey. In total, 1738 Indigenous Australians and 3098 non-Indigenous Australians were sampled from 30 sites. Participants underwent a questionnaire and self-reported their eye disease histories...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821756/toxicity-of-pine-monoterpenes-to-mountain-pine-beetle
#13
Christine C Chiu, Christopher I Keeling, Joerg Bohlmann
The mountain pine beetle (Dendroctonus ponderosae; MPB) is an eruptive bark beetle species affecting pine forests of western North America. MPB are exposed to volatile monoterpenes, which are important host defense chemicals. We assessed the toxicity of the ten most abundant monoterpenes of lodgepole pine (Pinus contorta), a major host in the current MPB epidemic, against adult MPB from two locations in British Columbia, Canada. Monoterpenes were tested as individual volatiles and included (-)-β-phellandrene, (+)-3-carene, myrcene, terpinolene, and both enantiomers of α-pinene, β-pinene and limonene...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28815159/short-posterior-stabilization-in-combination-with-cement-augmentation-for-the-treatment-of-thoracolumbar-fractures-and-the-effects-of-implant-removal
#14
Sven Hoppe, Emin Aghayev, Sufian Ahmad, Marius Johann Baptist Keel, Timo Michael Ecker, Moritz Deml, Lorin Michael Benneker
STUDY DESIGN: Retrospective case series. OBJECTIVE: Short posterior stabilization with vertebroplasty is one treatment option for thoracolumbar burst fractures (AO A3). Whether it avoids progression in segmental kyphosis, especially after implant removal, is unclear. In a retrospective case-control study, its stability and the effect on intervertebral discs with and without implant removal was studied. METHODS: Fifty-nine consecutive patients were treated with bisegmental short posterior instrumentation and additional vertebroplasty of the fractured vertebra...
June 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28811043/treatment-of-the-fixation-surface-improves-glenoid-prosthesis-longevity-in-vitro
#15
Sarah Junaid, Sanjay Sanghavi, Carolyn Anglin, Anthony Bull, Roger Emery, Andrew A Amis, Ulrich Hansen
Many commercial cemented glenoid components claim superior fixation designs and increased survivability. However, both research and clinical studies have shown conflicting results and it is unclear whether these design variations do improve loosening rates. Part of the difficulty in investigating fixation failure is the inability to directly observe the fixation interface, a problem addressed in this study by using a novel experimental set-up. Cyclic loading-displacement tests were carried out on 60 custom-made glenoid prostheses implanted into a bone substitute...
July 22, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28807628/vertebral-alveolar-echinococcosis-a-case-report-systematic-analysis-and-review-of-the-literature
#16
REVIEW
Thomas Raphael Meinel, Bruno Gottstein, Vanessa Geib, Marius Johann Keel, Ruggero Biral, Markus Mohaupt, Jan Brügger
Alveolar echinococcosis caused by Echinococcus multilocularis is an infrequent zoonosis with a high degree of disability, morbidity, and mortality, especially in disease clusters of the northern hemisphere. The diagnosis is complicated by extended incubation time, diverse clinical manifestations, and mimicking of differential diagnoses. The primary organ affected is the liver, but extrahepatic disease is possible, with vertebral involvement in only a few dozen cases described worldwide. Although vertebral alveolar echinococcosis seems to be rare, it might be under diagnosed, and it might be seen more often as the number of people with immunocompromised conditions increases...
August 11, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28796519/coarse-grained-modeling-of-antibodies-from-small-angle-scattering-profiles
#17
Daniel Corbett, Max Hebditch, Rose Keeling, Peng Ke, Sofia Ekizoglou, Prasad Sarangapani, Jai Pathak, Christopher F Van Der Walle, Shahid Uddin, Clair Baldock, Carlos Avendaño, Robin A Curtis
Predicting the concentrated solution behavior for monoclonal antibodies requires developing and using minimal models to describe their shape and interaction potential. Toward this end, the small-angle X-ray scattering (SAXS) profiles for a monoclonal antibody (COE-03) have been measured under solution conditions chosen to produce weak self-association. The experiments are complemented with molecular simulations of a three-bead antibody model with and without interbead attraction. The scattering profile is extracted directly from the molecular simulation to avoid using the decoupling approximation...
August 25, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28794282/partial-efficacy-of-a-broadly-neutralizing-antibody-against-cell-associated-shiv-infection
#18
Matthew S Parsons, Sarah B Lloyd, Wen Shi Lee, Anne B Kristensen, Thakshila Amarasena, Rob J Center, Brandon F Keele, Jeffrey D Lifson, Celia C LaBranche, David Montefiori, Bruce D Wines, P Mark Hogarth, Kristine M Swiderek, Vanessa Venturi, Miles P Davenport, Stephen J Kent
Broadly neutralizing antibodies (BnAbs) protect macaques from cell-free simian/human immunodeficiency virus (SHIV) challenge, but their efficacy against cell-associated SHIV is unclear. Virus in cell-associated format is highly infectious, present in transmission-competent bodily fluids, and potentially capable of evading antibody-mediated neutralization. The PGT121 BnAb, which recognizes an epitope consisting of the V3 loop and envelope glycans, mediates antibody-dependent cellular cytotoxicity and neutralization of cell-to-cell HIV-1 transmission...
August 9, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28793183/utilization-of-eye-health-care-services-in-australia-the-national-eye-health-survey
#19
Joshua Foreman, Jing Xie, Stuart Keel, Hugh R Taylor, Mohamed Dirani
IMPORTANCE: National data on eye health-care service utilization will inform Australia's eye health policy. BACKGROUND: To investigate the utilization of eye health-care services by Australians. DESIGN: Cross-sectional survey. PARTICIPANTS: Indigenous Australians aged 40 years and older and non-Indigenous Australians aged 50 years and older. METHODS: One thousand seven hundred thirty-eight Indigenous Australians and 3098 non-Indigenous Australians were recruited from 30 randomly selected sites, stratified by remoteness...
August 9, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28770347/web-thickness-determines-the-therapeutic-effect-of-endoscopic-keel-placement-on-anterior-glottic-web
#20
Jian Chen, Fang Shi, Min Chen, Yue Yang, Lei Cheng, Haitao Wu
This work is a retrospective analysis to investigate the critical risk factor for the therapeutic effect of endoscopic keel placement on anterior glottic web. Altogether, 36 patients with anterior glottic web undergoing endoscopic lysis and silicone keel placement were enrolled. Their voice qualities were evaluated using the voice handicap index-10 (VHI-10) questionnaire, and improved significantly 3 months after surgery (21.53 ± 3.89 vs 9.81 ± 6.68, P < 0.0001). However, 10 (27.8%) cases had web recurrence during the at least 1-year follow-up...
August 2, 2017: European Archives of Oto-rhino-laryngology
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