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Nina Caca-Biljanovska, Irina Arsovska-Bezhoska, Marija V'lckova-Laskoska
The association between psoriasis vulgaris and bullous pemphigoid is due to the still unclear autoimmune process. The common disease site is the dermo-epidermal junction or basal membrane zone (BMZ), with specific alterations for both diseases. Photochemotherapy (PUVA) is one of the therapeutic modalities for psoriasis and can trigger production of autoantibodies against antigens in the BMZ in patients with subclinical bullous pemphigoid. Furthermore, PUVA therapy can alter the immunological milieu and hence can contribute to the expression of bullous pemphigoid in patients with psoriasis...
August 2016: Acta Dermatovenerologica Croatica: ADC
Arthur Schmidt, Karel Caca
No abstract text is available yet for this article.
August 8, 2016: Deutsches Ärzteblatt International
Muhammed Şahin, Alparslan Şahin, Faruk Kılınç, Harun Yüksel, Zeynep Gürsel Özkurt, Fatih Mehmet Türkcü, Zafer Pekkolay, Hikmet Soylu, İhsan Çaça
Increased secretion of growth hormone and insulin-like growth factor-1 in acromegaly has various effects on multiple organs. However, the ocular effects of acromegaly have yet to be investigated in detail. The aim of the present study was to compare retina ganglion cell/inner plexiform layer (GCIPL) and peripapillary nerve fiber layer thickness (pRNFL) between patients with acromegaly and healthy control subjects using spectral domain optical coherence tomography (SD-OCT). This cross-sectional, comparative study included 18 patients with acromegaly and 20 control subjects...
August 4, 2016: International Ophthalmology
Jean-Luc Cacas, Martial Pré, Maxime Pizot, Maimouna Cissoko, Issa Diedhiou, Aida Jalloul, Patrick Doumas, Michel Nicole, Antony Champion
The phytohormone jasmonic acid (JA) and its derivatives, collectively referred to as jasmonates, regulate many developmental processes, but are also involved in response to numerous abiotic/biotic stresses. Thus far, powerful reverse genetic strategies employing perception, signaling or biosynthesis mutants have broadly contributed to our understanding of JA implication in plant stress response and development; so did the chemical gain-of-function approach based on exogenous application of the hormone. However, there is currently no method that allows for in planta tightly controlled JA production...
June 13, 2016: Molecular Plant Pathology
Jean-Luc Cacas, Patricia Gerbeau-Pissot, Jérôme Fromentin, Catherine Cantrel, Dominique Thomas, Emmanuelle Jeannette, Tetiana Kalachova, Sébastien Mongrand, Françoise Simon-Plas, Eric Ruelland
Cryptogein is a 10 kDa-protein secreted by the oomycete Phytophthora cryptogea that activates defence mechanisms in tobacco plants. Among early signalling events triggered by this microbial-associated molecular pattern is a transient apoplastic oxidative burst which is dependent on the NADPH oxidase activity of the RESPIRATORY BURST OXIDASE HOMOLOG (RBOH) isoform D. Using radioactive [(33) P]-orthophosphate labelling of tobacco Bright Yellow-2 suspension cells, we here provide in vivo evidence for a rapid accumulation of phosphatidic acid (PA) in response to cryptogein due to the coordinated onset of phosphoinositide-dependent phospholipase C and diacylglycerol kinase (DGK) activities...
June 6, 2016: Plant, Cell & Environment
Julien Gronnier, Véronique Germain, Paul Gouguet, Jean-Luc Cacas, Sébastien Mongrand
What are the most abundant sphingolipids on earth? The answer is Glycosyl Inositol Phosphoryl Ceramides (GIPCs) present in fungi and the green lineage. In this review, we discuss the putative role of plant GIPCs in the lipid bilayer asymmetry, in the lateral organization of membrane rafts and in the very long chain fatty acid inter-leaflet coupling of lipids in the plant plasma membrane (PM). A special focus on the structural similarities -and putative functions- of GIPCs is discussed by comparison with animal gangliosides, structural homologs of plant GIPCs...
2016: Plant Signaling & Behavior
Markus Bauder, Arthur Schmidt, Karel Caca
Recent developments have expanded the frontier of interventional endoscopy toward more extended resections following surgical principles. This article presents two new device-assisted techniques for endoscopic full-thickness resection in the upper and lower gastrointestinal tract. Both methods are nonexposure techniques avoiding exposure of gastrointestinal contents to the peritoneal cavity by a "close first-cut later" principle. The full-thickness resection device is a novel over-the-scope device designed for clip-assisted full-thickness resection of colorectal lesions...
April 2016: Gastrointestinal Endoscopy Clinics of North America
Arthur Schmidt, Karl-Hermann Fuchs, Karel Caca, Armin Küllmer, Alexander Meining
BACKGROUND: Iatrogenic gastrointestinal perforation is a life-threatening complication that arises very rarely in routine endoscopic procedures, with an incidence of 0.03-0.8%. It is more likely in highly complex and invasive therapeutic interventions. In certain situations, endoscopic closure of the perforation and treatment with antibiotics can obviate the need for emergency surgical repair. METHODS: This review is based on pertinent articles retrieved by a selective literature search in PubMed and on a relevant position paper...
February 26, 2016: Deutsches Ärzteblatt International
Fatih Mehmet Türkcü, Alparslan Şahin, Harun Yüksel, Meltem Akkurt, Derya Uçmak, Yasin Çınar, Adnan Yıldırım, İhsan Çaça
The purpose of this study was to evaluate choroidal thickness (CT) in patients with psoriasis using enhanced depth imaging optical coherence tomography (EDI-OCT) and to determine its relationship with psoriasis activity indices. In this prospective study, EDI-OCT images were obtained in consecutive patients with psoriasis and in age-gender-matched healthy individuals. Comprehensive ophthalmic examination and EDI-OCT evaluation were performed. CT was measured in the subfoveal area. Correlation analyses were performed to identify the relationship of the CT with disease duration and clinical disease activity score...
March 8, 2016: International Ophthalmology
Joachim Behar, Yael Yaniv
Cardiac pacemaker cell function is regulated by a coupled-clock system that integrates molecular cues on the cell-membrane surface (i.e., membrane clock) and on the sarcoplasmic reticulum (SR) (i.e., Ca(2+) clock). A recent study has shown that cotransfection of spontaneous beating cells (HEK293 cells and neonatal rat myocytes) with R524Q-mutant human hyperpolarization-activated cyclic nucleotide-gated molecules (the dominant component of funny channels) increases the funny channel's sensitivity to cAMP and leads to a decrease in spontaneous action potential (AP) cycle length (i...
May 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
Jon K Pittman, Kendal D Hirschi
BACKGROUND: The Ca(2+)/Cation Antiporter (CaCA) superfamily is an ancient and widespread family of ion-coupled cation transporters found in nearly all kingdoms of life. In animals, K(+)-dependent and K(+)-indendent Na(+)/Ca(2+) exchangers (NCKX and NCX) are important CaCA members. Recently it was proposed that all rice and Arabidopsis CaCA proteins should be classified as NCX proteins. Here we performed phylogenetic analysis of CaCA genes and protein structure homology modelling to further characterise members of this transporter superfamily...
December 2016: Rice
P M Tomasula, A M M Sousa, S-C Liou, R Li, L M Bonnaillie, L S Liu
Electrospinning is a complex process that produces fibers with diameters on the micrometer or nano-scale from an electrified jet of a polymer solution. The objective of this study was to create electrospun fibers for food use from aqueous solutions of calcium (CaCAS) or sodium caseinate (NaCAS). Fibers were not formed from electrospinning of solutions of either caseinate (CAS) at 50 °C, but were formed from blends of either CAS solution with aqueous solutions of the food-grade polysaccharide, pullulan (PUL), when using mass ratios from 2:1 to 1:4 of PUL/CAS...
March 2016: Journal of Dairy Science
Ali H Jalloul, Robert T Szerencsei, Paul P M Schnetkamp
The Solute Carrier Family 24 (SLC24) belongs to the CaCA super family of Ca(2+)/cation antiporters and codes for five different K(+)- dependent Na(+)- Ca(2+) exchangers (NCKX1-5). NCKX proteins play a critical role in Ca(2+) homeostasis in a wide variety of biological processes such as vision, olfaction, enamel formation, Melanocortin-4-receptor-dependent satiety and skin pigmentation. NCKX transcripts are widely found throughout the brain. In this study we examine the differences between NCKX1-4 in terms of cation dependencies...
January 2016: Cell Calcium
Akhilesh K Yadav, Alka Shankar, Saroj K Jha, Poonam Kanwar, Amita Pandey, Girdhar K Pandey
In plant cell, cations gradient in cellular compartments is maintained by synergistic action of various exchangers, pumps and channels. The Arabidopsis exchanger family members (AtCCX3 and AtCCX5) were previously studied and belong to CaCA (calcium cation exchangers) superfamily while none of the rice CCXs has been functionally characterized for their cation transport activities till date. Rice genome encode four CCXs and only OsCCX2 transcript showed differential expression under abiotic stresses and Ca(2+) starvation conditions...
November 26, 2015: Scientific Reports
Binghe Xu, Xichun Hu, Zefei Jiang, Huiping Li, Jiayi Chen, Shude Cui, Qing Li, Ning Liao, Donggeng Liu, Jian Liu, Jinsong Lu, Kunwei Shen, Tao Sun, Yuee Teng, Zhongsheng Tong, Shulian Wang, Xiang Wang, Xiaojia Wang, Yongsheng Wang, Jiong Wu, Peng Yuan, Pin Zhang, Qingyuan Zhang, Hong Zheng, Da Pang, Guosheng Ren, Zhimin Shao, Zhenzhou Shen, Erwei Song, Santai Song
The recently available guidelines on the management of advanced breast cancer (ABC) organized by Chinese Anti-Cancer Association, Committee of Breast Cancer Society (CACA-CBCS) do not elucidate ABC in details. To instruct clinicians in treatment of ABC, a Chinese expert consensus meeting on diagnosis and treatment of ABC was held in June 2014 and a consensus is developed. The following consensus provides the level of evidence and supporting documents for each recommendation, and introduces research topics to be urgently addressed...
October 2015: Annals of Translational Medicine
Armin Küllmer, Arthur Schmidt, Karel Caca
We report on two patients with recurrent episodes of chronic intestinal pseudo-obstruction (CIPO). A 50-year-old woman with severe multiple sclerosis and an 84-year-old man with Parkinson's disease and dementia had multiple hospital admissions because of pain and distended abdomen. Radiographic and endoscopic findings showed massive dilation of the colon without any evidence of obstruction. Conservative management resolved symptoms only for a short period of time. As these patients were poor candidates for any surgical treatment we carried out percutaneous endoscopic colostomy by placing a 20-Fr tube in the cecum with the introducer method...
March 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
W A A Borstlap, C J Buskens, K M A J Tytgat, J B Tuynman, E C J Consten, R C Tolboom, G Heuff, A A W van Geloven, B A van Wagensveld, C A C A Wientjes, M F Gerhards, S M M de Castro, J Jansen, A W H van der Ven, E van der Zaag, J M Omloo, H L van Westreenen, D C Winter, R P Kennelly, M G W Dijkgraaf, P J Tanis, W A Bemelman
No abstract text is available yet for this article.
2015: BMC Surgery
Tingting Xu
Cancer has become the first leading cause of death in the world, particularly in low- and middle-income countries. Facing the increasing trend of cancer incidence and mortality, China issued and implemented "three-early (early prevention, early diagnosis and early treatment)" national cancer prevention plan. As the main body and dependence of social governance, non-governmental organizations (NGOs) take over the role of government in the field of cancer prevention and treatment. American Cancer Society (ACS) made a research on cancer NGOs and civil society in cancer control and found that cancer NGOs in developing countries mobilize civil society to work together and advocate governments in their countries to develop policies to address the growing cancer burden...
August 2015: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
R Tadavarty, J Hwang, P S Rajput, P J Soja, U Kumar, B R Sastry
We investigated the anti-nociceptive effects of GABA-C receptors in the central nervous system. Intracisternal injection of CACA, a GABA-C receptor agonist or isoguvacine, a GABA-A receptor agonist, significantly increased the tail-withdrawal latency. TPMPA, a GABA-C receptor antagonist blocked the effects of CACA but not isoguvacine indicating that GABA-C receptors are involved in regulating pain. Further, double-labelled immunofluorescence studies revealed that GABA-Cρ2 receptors are expressed presynaptically in the spinal dorsal horn, especially, substantia gelatinosa, a region that has been previously implicated in analgesia by regulating nociceptive inflow...
October 8, 2015: Neuroscience Letters
Arthur Schmidt, Benjamin Meier, Karel Caca
Conventional endoscopic resection techniques such as endoscopic mucosal resection or endoscopic submucosal dissection are powerful tools for treatment of gastrointestinal neoplasms. However, those techniques are restricted to superficial layers of the gastrointestinal wall. Endoscopic full-thickness resection (EFTR) is an evolving technique, which is just about to enter clinical routine. It is not only a powerful tool for diagnostic tissue acquisition but also has the potential to spare surgical therapy in selected patients...
August 21, 2015: World Journal of Gastroenterology: WJG
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