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M Oster

Gerry Oster, Sean D Sullivan, Mehul R Dalal, Mahmood R Kazemi, Maria Rojeski, Carol H Wysham, Jennifer Sung, Bryan Johnstone, Anna M G Cali, L J Wei, Louise Traylor, Henry Anhalt, Michelle Hull, John Van Vleet, Luigi F Meneghini
OBJECTIVE: This study aims to compare the effectiveness of insulin glargine 300 U/mL (Gla-300) with its accompanying patient support program with that of other basal insulin and available patient support programs in patients with type 2 diabetes (T2D) in a real-world setting in terms of achieving HEDIS (Healthcare Effectiveness Data and Information Set) individualized glycemic targets without documented symptomatic hypoglycemia. STUDY DESIGN AND METHODS: Achieve Control is a US-based, multicenter, randomized, open-label, active-controlled, parallel group pragmatic Phase IV trial in insulin-naïve patients with T2D uncontrolled on ≥2 oral antidiabetes drugs (OAD) and/or glucagon-like peptide-1 receptor antagonists (GLP-1 RA)...
October 3, 2016: Postgraduate Medicine
Carmen C Canavier, Rebekah C Evans, Andrew M Oster, Eleftheria K Pissadaki, Guillaume Drion, Alexey S Kuznetsov, Boris Samuel Gutkin
This review addresses the current state of single cell models of the firing pattern of midbrain dopamine neurons, and the insights that can be gained from these models into the underlying mechanisms for diseases such as Parkinson's, addiction, and schizophrenia. We will explain the analytical technique of separation of time scales and show how it can produce insights into mechanisms using simplified single compartment models. We also use morphologically realistic multi-compartmental models to address spatially heterogeneous aspects of neural signaling and neural metabolism...
August 31, 2016: Journal of Neurophysiology
Moshe Mittelman, Kalman Filanovsky, Yishai Ofran, Hanna Rosenbaum, Pia Raanani, Andrei Braester, Neta Goldschmidt, Ilya Kirgner, Yair Herishanu, Chava Perri, Martin Ellis, Howard S Oster
Azacitidine treatment is effective in higher risk MDS (HR-MDS), with less than 50 % response, lasting 2 years. Aza and lenalidomide (Len) have a potential synergistic effect. ViLen-01 phase IIa trial includes 6-month induction (Aza 75 mg/m(2)/day, days 1-5, Len 10 mg/day, days 6-21, every 28 days), 6-month consolidation (Aza 75 mg/m(2)/day, days 1-5, every 28 days), and 12-month maintenance (Len 10 mg/day, days 1-21, every 28 days). Response was evaluated according to IWG criteria. Totally, 25 patients enrolled, with an average of 76...
October 2016: Annals of Hematology
Laura L Dover, Robert A Oster, Andrew M McDonald, Derek A DuBay, Thomas N Wang, Rojymon Jacob
BACKGROUND: The ideal adjuvant therapy for resected cholangiocarcinoma remains controversial. National guidelines stratify recommendations based on margin status, though few studies are currently available for reference. METHODS: Data was abstracted on all patients with definitive resections of cholangiocarcinoma at our institution between 2000 and 2013. Adjuvant chemoradiation consisted of 45 Gy delivered to elective nodal regions and 50.4-54 Gy to the surgical bed with concurrent fluoropyrimidine-based chemotherapy...
October 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Jasmine A Nirody, Richard M Berry, George Oster
Recent experiments on the bacterial flagellar motor have shown that the structure of this nanomachine, which drives locomotion in a wide range of bacterial species, is more dynamic than previously believed. Specifically, the number of active torque-generating complexes (stators) was shown to vary across applied loads. This finding brings under scrutiny the experimental evidence reporting that limiting (zero-torque) speed is independent of the number of active stators. In this study, we propose that, contrary to previous assumptions, the maximum speed of the motor increases as additional stators are recruited...
August 9, 2016: Biophysical Journal
Logan G Spector, Jeremiah S Menk, Jeffrey M Vinocur, Matthew E Oster, Brian A Harvey, James D St Louis, James Moller, Lazaros K Kochilas
BACKGROUND: The long-term outcomes of patients undergoing interventions for congenital heart disease (CHD) remain largely unknown. We linked the Pediatric Cardiac Care Consortium (PCCC) with the National Death Index (NDI) and the United Network for Organ Sharing Dataset (UNOS) registries to study mortality and transplant occurring up to 32 years postintervention. The objective of the current analysis was to determine the sensitivity of this linkage in identifying patients who are known to have died or undergone heart transplant...
2016: Journal of the American Heart Association
Jonathan M Lamley, Carl Öster, Rebecca A Stevens, Józef R Lewandowski
Understanding the dynamics of interacting proteins is a crucial step toward describing many biophysical processes. Here we investigate the backbone dynamics for protein GB1 in two different assemblies: crystalline GB1 and the precipitated GB1-antibody complex with a molecular weight of more than 300 kDa. We perform these measurements on samples containing as little as eight nanomoles of GB1. From measurements of site-specific (15)N relaxation rates including relaxation dispersion we obtain snapshots of dynamics spanning nine orders of magnitude in terms of the time scale...
December 14, 2015: Angewandte Chemie
James M Richter, Nabeela K Arshi, Gerry Oster
Background. Ulcerative proctitis (UP) is typically treated initially with oral 5-aminosalicylate ("5-ASA"), mesalamine suppository, or mesalamine enema ("UP Rx"). Little is known about their effectiveness in practice. Methods. Using a US health insurance database, we identified new-onset UP patients between January 1, 2005, and December 31, 2007, based on the following: (1) initiation of UP Rx; (2) endoscopy in prior 30 days resulting in diagnosis of UP; and (3) no prior encounters for ulcerative colitis or Crohn's disease...
2016: Canadian Journal of Gastroenterology & Hepatology
Matthew C Davis, Elizabeth N Kuhn, Bonita S Agee, Robert A Oster, James M Markert
OBJECTIVE Many neurosurgical training programs have moved from a 24-hour resident call system to a night float system, but the impact on outcomes is unclear. Here, the authors compare length of stay (LOS) for neurosurgical patients admitted before and after initiation of a night float system at a tertiary care training hospital. METHODS The neurosurgical residency at the University of Alabama at Birmingham transitioned from 24-hour call to a night float resident coverage system in July 2013. In this cohort study, all patients admitted to the neurosurgical service for 1 year before and 1 year after this transition were compared with respect to hospital and ICU LOSs, adjusted for potential confounders...
July 8, 2016: Journal of Neurosurgery
Chris A Van Beneden, Harald Pietz, Robert D Kirkcaldy, Lisa M Koonin, Timothy M Uyeki, Alexandra M Oster, Deborah A Levy, Maleeka Glover, Matthew J Arduino, Toby L Merlin, David T Kuhar, Christine Kosmos, Beth P Bell
In response to the 2014-2016 Ebola virus disease (Ebola) epidemic in West Africa, CDC prepared for the potential introduction of Ebola into the United States. The immediate goals were to rapidly identify and isolate any cases of Ebola, prevent transmission, and promote timely treatment of affected patients. CDC's technical expertise and the collaboration of multiple partners in state, local, and municipal public health departments; health care facilities; emergency medical services; and U.S. government agencies were essential to the domestic preparedness and response to the Ebola epidemic and relied on longstanding partnerships...
2016: MMWR Supplements
Suzanne M Gilboa, Owen J Devine, James E Kucik, Matthew E Oster, Tiffany Riehle-Colarusso, Wendy N Nembhard, Ping Xu, Adolfo Correa, Kathy Jenkins, Ariane J Marelli
BACKGROUND: Because of advancements in care, there has been a decline in mortality from congenital heart defects (CHDs) over the past several decades. However, there are no current empirical data documenting the number of people living with CHDs in the United States. Our aim was to estimate the CHD prevalence across all age groups in the United States in the year 2010. METHODS: The age-, sex-, and severity-specific observed prevalence of CHDs in Québec, Canada, in the year 2010 was assumed to equal the CHD prevalence in the non-Hispanic white population in the United States in 2010...
July 12, 2016: Circulation
Kirsten Rose-Felker, Michael S Kelleman, Robert M Campbell, Matthew E Oster, Ritu Sachdeva
OBJECTIVE: To determine the appropriateness and yield of transthoracic echocardiograms (TTE) for murmur evaluation based on the pediatric Appropriate Use Criteria (AUC) and study the influence of patient age and physician experience on TTE appropriateness, yield, and ordering frequency. DESIGN: Retrospective review of medical records of patients referred to our practice for murmur evaluation from April to September 2014. Data collected included indication for TTE, patient age, physician experience since fellowship, TTE findings and exit diagnosis...
June 10, 2016: Congenital Heart Disease
Matthew E Oster, Susan W Aucott, Jill Glidewell, Jesse Hackell, Lazaros Kochilas, Gerard R Martin, Julia Phillippi, Nelangi M Pinto, Annamarie Saarinen, Marci Sontag, Alex R Kemper
Newborn screening for critical congenital heart defects (CCHD) was added to the US Recommended Uniform Screening Panel in 2011. Within 4 years, 46 states and the District of Columbia had adopted it into their newborn screening program, leading to CCHD screening being nearly universal in the United States. This rapid adoption occurred while there were still questions about the effectiveness of the recommended screening protocol and barriers to follow-up for infants with a positive screen. In response, the Centers for Disease Control and Prevention partnered with the American Academy of Pediatrics to convene an expert panel between January and September 2015 representing a broad array of primary care, neonatology, pediatric cardiology, nursing, midwifery, public health, and advocacy communities...
May 2016: Pediatrics
Katelyn Bowman Feinberg, Nada M Souccar, Chung H Kau, Robert A Oster, Nathaniel C Lawson
No abstract text is available yet for this article.
March 2016: Journal of Clinical Orthodontics: JCO
Joel O Wertheim, Alexandra M Oster, Angela L Hernandez, Neeraja Saduvala, M Cheryl Bañez Ocfemia, Irene Hall
The majority of HIV infections in the United States can be traced back to a single introduction in late-1960s or early 1970s. However, it remains unclear whether subsequent introductions of HIV into the United States have given rise to onward transmission. Genetic transmission networks can aid in understanding HIV transmission. We constructed a genetic distance-based transmission network using HIV-1 pol sequences reported to the U.S. National HIV Surveillance System (n=41,539) and all publicly available non-U...
April 22, 2016: AIDS Research and Human Retroviruses
Patricia A Carney, Kimberly H Allison, Natalia V Oster, Paul D Frederick, Thomas R Morgan, Berta M Geller, Donald L Weaver, Joann G Elmore
We examined how pathologists' process their perceptions of how their interpretations on diagnoses for breast pathology cases agree with a reference standard. To accomplish this, we created an individualized self-directed continuing medical education program that showed pathologists interpreting breast specimens how their interpretations on a test set compared with a reference diagnosis developed by a consensus panel of experienced breast pathologists. After interpreting a test set of 60 cases, 92 participating pathologists were asked to estimate how their interpretations compared with the standard for benign without atypia, atypia, ductal carcinoma in situ and invasive cancer...
July 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Alexandra M Oster, Kate Russell, Jo Ellen Stryker, Allison Friedman, Rachel E Kachur, Emily E Petersen, Denise J Jamieson, Amanda C Cohn, John T Brooks
CDC issued interim guidance for the prevention of sexual transmission of Zika virus on February 5, 2016. The following recommendations apply to men who have traveled to or reside in areas with active Zika virus transmission and their female or male sex partners. These recommendations replace the previously issued recommendations and are updated to include time intervals after travel to areas with active Zika virus transmission or after Zika virus infection for taking precautions to reduce the risk for sexual transmission...
2016: MMWR. Morbidity and Mortality Weekly Report
Emily E Petersen, Kara N D Polen, Dana Meaney-Delman, Sascha R Ellington, Titilope Oduyebo, Amanda Cohn, Alexandra M Oster, Kate Russell, Jennifer F Kawwass, Mateusz P Karwowski, Ann M Powers, Jeanne Bertolli, John T Brooks, Dmitry Kissin, Julie Villanueva, Jorge Muñoz-Jordan, Matthew Kuehnert, Christine K Olson, Margaret A Honein, Maria Rivera, Denise J Jamieson, Sonja A Rasmussen
CDC has updated its interim guidance for U.S. health care providers caring for women of reproductive age with possible Zika virus exposure to include recommendations on counseling women and men with possible Zika virus exposure who are interested in conceiving. This guidance is based on limited available data on persistence of Zika virus RNA in blood and semen. Women who have Zika virus disease should wait at least 8 weeks after symptom onset to attempt conception, and men with Zika virus disease should wait at least 6 months after symptom onset to attempt conception...
2016: MMWR. Morbidity and Mortality Weekly Report
Sherry L Farr, Matthew E Oster, Regina M Simeone, Suzanne M Gilboa, Margaret A Honein
BACKGROUND: Little population-based data exist on limitations and health-related quality of life (HRQoL) in adults with congenital heart defects (CHD). METHODS: We used 2004 to 2012 Medical Expenditure Panel Survey data to identify a population-based sample of young adults ages 18 to 40 years reporting health symptoms or healthcare encounters in the previous year. Comparing adults reporting CHD to others, we examined the prevalence of cognitive, physical, and activity limitations, depressive symptoms, and physical and mental HRQoL...
July 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
Sarah F Wulf, Virginie Ropars, Setsuko Fujita-Becker, Marco Oster, Goetz Hofhaus, Leonardo G Trabuco, Olena Pylypenko, H Lee Sweeney, Anne M Houdusse, Rasmus R Schröder
Molecular motors produce force when they interact with their cellular tracks. For myosin motors, the primary force-generating state has MgADP tightly bound, whereas myosin is strongly bound to actin. We have generated an 8-Å cryoEM reconstruction of this state for myosin V and used molecular dynamics flexed fitting for model building. We compare this state to the subsequent state on actin (Rigor). The ADP-bound structure reveals that the actin-binding cleft is closed, even though MgADP is tightly bound. This state is accomplished by a previously unseen conformation of the β-sheet underlying the nucleotide pocket...
March 29, 2016: Proceedings of the National Academy of Sciences of the United States of America
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