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https://www.readbyqxmd.com/read/29893239/phylogenetic-analyses-of-local-hiv-transmission
#1
Patrick S Sullivan, Alexandra M Oster
No abstract text is available yet for this article.
June 2018: Lancet HIV
https://www.readbyqxmd.com/read/29793633/trends-in-long-term-mortality-after-congenital-heart-surgery
#2
Logan G Spector, Jeremiah S Menk, Jessica H Knight, Courtney McCracken, Amanda S Thomas, Jeffrey M Vinocur, Matthew E Oster, James D St Louis, James H Moller, Lazaros Kochilas
BACKGROUND: Congenital heart surgery has improved the survival of patients with even the most complex defects, but the long-term survival after these procedures has not been fully described. OBJECTIVES: The purpose of this study was to evaluate the long-term survival of patients (age <21 years) who were operated on for congenital heart defects (CHDs). METHODS: This study used the Pediatric Cardiac Care Consortium data, a U.S.-based, multicenter registry of pediatric cardiac surgery...
May 29, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29606693/canadian-alliance-for-healthy-hearts-and-minds-first-nations-cohort-study-rationale-and-design
#3
Sonia S Anand, Sylvia Abonyi, Laura Arbour, Jeff Brook, Sharon Bruce, Heather Castleden, Dipika Desai, Russell J de Souza, Stewart Harris, James Irvine, Christopher Lai, Diana Lewis, Richard T Oster, Paul Poirier, Ellen L Toth, Karen Bannon, Vicky Chrisjohn, Albertha D Davis, Jean L'Hommecourt, Randy Littlechild, Kathleen McMullin, Sarah McIntosh, Julie Morrison, Manon Picard, Pictou Landing First Nation, Melissa M Thomas, Natasa Tusevljak, Matthias G Friedrich, Jack V Tu
BACKGROUND: This is the first national indigenous cohort study in which a common, in-depth protocol with a common set of objectives has been adopted by several indigenous communities across Canada. OBJECTIVES: The overarching objective of the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort is to investigate how the community-level environment is associated with individual health behaviors and the presence and progression of chronic disease risk factors and chronic diseases such as cardiovascular disease (CVD) and cancer...
2018: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/29505765/kshv-hhv8-associated-extracavitary-primary-effusion-lymphoma-presenting-as-multiple-lymphomatous-polyposis
#4
M D Cyrus Oster, M D Theodore Stein, M D Sumire Kitahara, M D Serhan Alkan, Qin Huang
Primary effusion lymphoma (PEL) is a distinct clinicopathologic entity usually characterized by presentation as a lymphomatous body cavity effusion in the absence of solid tumor mass or dissemination during its clinical course. PEL can also rarely occur as a solid lymphoma involving nodal and extranodal sites and is referred to as extracavitary PEL. Here we report a unique case of extracavitary PEL in a 49year-old HIV-seropositive patient, who presented with vague abdominal pain and 20 pound weight loss. Esophagogastroduodenoscopy and colonoscopy revealed >100 broad based intestinal polyps ranging from 2 mm to 3cm in size, spreading from the duodenum to the rectum as a typical impression of "intestinal polyposis syndrome"...
March 2, 2018: Human Pathology
https://www.readbyqxmd.com/read/29503471/phylogeny-of-the-order-phyllachorales-ascomycota-sordariomycetes-among-and-within-order-relationships-based-on-five-molecular-loci
#5
M Mardones, T Trampe-Jaschik, S Oster, M Elliott, H Urbina, I Schmitt, M Piepenbring
The order Phyllachorales ( Pezizomycotina , Ascomycota ) is a group of biotrophic, obligate plant parasitic fungi with a tropical distribution and high host specificity. Traditionally two families are recognised within this order: Phyllachoraceae and Phaeochoraceae , based mostly on morphological and host characteristics. Currently, the position of the order within the class Sordariomycetes is inconclusive, as well as the monophyly of the order, and its internal phylogenetic structure. Here we present a phylogeny of the order Phyllachorales based on sequence data of 29 species with a broad host range resulting from a wide geographical sampling...
December 2017: Persoonia
https://www.readbyqxmd.com/read/29494292/paralytic-and-non-paralytic-muscle-adaptations-to-exercise-training-vs-high-protein-diet-in-individuals-with-long-standing-spinal-cord-injury
#6
Ceren Yarar-Fisher, Keith Fl Polston, Mualla Eraslan, Kathryn Y Henley, Gizem I Kinikli, C Scott Bickel, Samuel T Windham, Amie B McLain, Robert A Oster, Marcas M Bamman
This study compares the effects of an 8-week iso-caloric high protein (HP) diet versus a combination exercise (Comb-Ex) regimen on paralytic vastus lateralis (VL) and non-paralytic deltoid muscle in individuals with long-standing spinal cord injury (SCI). Fiber type distribution, cross-sectional area (CSA), levels of translation initiation signaling proteins (Erk-1/2, Akt, p70S6K1, 4EBP1, RPS6, and FAK), and lean thigh mass were analyzed at baseline and after the 8-week interventions. A total of 11 participants (C5-T12 levels, 21...
March 1, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29470457/hiv-diagnoses-among-persons-aged-13-29-years-united-states-2010-2014
#7
M Cheryl Bañez Ocfemia, Richard Dunville, Tianchi Zhang, Lisa C Barrios, Alexandra M Oster
In 2014, persons aged 13-29 years represented 23% of the U.S. population, yet accounted for 40% of diagnoses of human immunodeficiency virus (HIV) infection during the same year (1). During 2010-2014, the rates of diagnosis of HIV infection decreased among persons aged 15-19 years, were stable among persons aged 20-24 years, and increased among persons aged 25-29 years (1). However, these 5-year age groups encompass multiple developmental stages and potentially mask trends associated with the rapid psychosocial changes during adolescence through young adulthood...
February 23, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29414779/structure-and-biophysical-characterization-of-the-human-full-length-neurturin-gfra2-complex-a-role-for-heparan-sulfate-in-signaling
#8
Jenny Sandmark, Göran Dahl, Linda Öster, Bingze Xu, Patrik Johansson, Tomas Akerud, Anna Aagaard, Pia Davidsson, Janna M Bigalke, Maria Sörhede Winzell, G Jonah Rainey, Robert G Roth
Neurturin (NRTN) provides trophic support to neurons and is considered a therapeutic agent for neurodegenerative diseases, such as Parkinson's disease. It binds to its co-receptor GFRa2, and the resulting NRTN-GFRa2 complex activates the transmembrane receptors rearranged during transfection (RET) or the neural cell adhesion molecule (NCAM). We report the crystal structure of NRTN, alone and in complex with GFRa2. This is the first crystal structure of a GFRa with all three domains and shows that domain 1 does not interact directly with NRTN, but it may support an interaction with RET and/or NCAM, via a highly conserved surface...
April 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29247922/analysis-of-meat-quality-traits-and-gene-expression-profiling-of-pigs-divergent-in-residual-feed-intake
#9
Justyna Horodyska, Michael Oster, Henry Reyer, Anne Maria Mullen, Peadar G Lawlor, Klaus Wimmers, Ruth M Hamill
Residual feed intake (RFI), the difference between actual feed intake and predicted feed requirements, is suggested to impact various aspects of meat quality. The objective of this study was to investigate the molecular mechanisms underpinning the relationship between RFI and meat quality. Technological, sensory and nutritional analysis as well as transcriptome profiling were carried out in Longissimus thoracis et lumborum muscle of pigs divergent in RFI (n=20). Significant differences in sensory profile and texture suggest a minor impairment of meat quality in more efficient pigs...
March 2018: Meat Science
https://www.readbyqxmd.com/read/29178324/effect-of-lsr-polymorphism-on-blood-lipid-levels-and-age-specific-epistatic-interaction-with-the-apoe-common-polymorphism
#10
T Xie, M G Stathopoulou, S Akbar, T Oster, G Siest, F T Yen, S Visvikis-Siest
The lipolysis stimulated lipoprotein receptor (LSR) is an apolipoprotein (Apo) B and ApoE receptor that participates in the removal of triglyceride-rich lipoproteins during the postprandial phase. LSR gene is located upstream of APOE, an important risk factor for cardiovascular disease (CVD). Since the APOE common polymorphism significantly affects the variability of lipid metabolism, this study aimed to determine the potential impact of a functional SNP rs916147 in LSR gene on lipid traits in healthy subjects and to investigate potential epistatic interaction between LSR and APOE...
April 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29153758/will-use-of-patient-portals-help-to-educate-and-communicate-with-patients-with-diabetes
#11
Sara L Jackson, Catherine M DesRoches, Dominick L Frosch, Sue Peacock, Natalia V Oster, Joann G Elmore
OBJECTIVE: Chronic disease management can require daily attention, and increased levels of patient activation and engagement. We examined whether patients with diabetes perceive a greater benefit to having electronic access to their doctors' clinic notes compared to patients without diabetes. We hypothesized that easy electronic access to these notes may help patients with self-care by improving education and communication. METHODS: Survey of patients with and without diabetes in Massachusetts and Pennsylvania about perceptions of potential benefits and risks of reading their visit notes via an electronic patient information portal...
May 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/29150179/-therapeutic-strategies-in-patients-undergoing-surgery-for-non-small-cell-lung-cancer-results-of-the-escap-2011-cphg-study-promoted-by-the-french-college-of-general-hospital-respiratory-physicians-cphg
#12
F Pinquié, F Goupil, J-P Oster, A Dixmier, P-A Renault, A Lévy, J-P Mathieu, N Paillot, F C Goutorbe, P Masson, O Molinier, D Debieuvre, M Grivaux
BACKGROUND: The aim of ESCAP-2011-CPHG, promoted by the French College of General Hospital Respiratory Physicians, was to describe therapeutic strategies in lung cancer in the first 2 years after diagnosis, in a real-life setting. This article focuses on patients undergoing surgical management of a non-small cell lung cancer (NSCLC). METHODS: A prospective multicentre study was conducted in 53 French general hospitals. For each patient with lung cancer diagnosed in 2010, a standardised form was completed following each change in treatment strategy up to 2 years after diagnosis...
November 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29095554/patients-perceptions-of-their-doctors-notes-and-after-visit-summaries-a-mixed-methods-study-of-patients-at-safety-net-clinics
#13
Brittaney M Belyeu, Jared W Klein, Lisa M Reisch, Sue Peacock, Natalia V Oster, Joann G Elmore, Sara L Jackson
BACKGROUND: Patients are increasingly offered electronic access to their doctors' notes, and many consistently receive paper After-Visit Summaries. Specific feedback from patients about notes and summaries are lacking, particularly within safety-net settings. DESIGN: A mixed methods study SETTING AND PARTICIPANTS: Patients with poorly controlled diabetes attending two urban safety-net primary care clinics in Washington State. METHODS: Patients read their own most recent clinic note and After-Visit Summary, then completed a brief survey followed by a focus group discussion (3 groups in a large general medicine teaching clinic and 1 in an HIV/AIDS clinic) about their perceptions of the clinic note and After-Visit Summary...
April 2018: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29082029/statistical-competencies-for-medical-research-learners-what-is-fundamental
#14
Felicity T Enders, Christopher J Lindsell, Leah J Welty, Emma K T Benn, Susan M Perkins, Matthew S Mayo, Mohammad H Rahbar, Kelley M Kidwell, Sally W Thurston, Heidi Spratt, Steven C Grambow, Joseph Larson, Rickey E Carter, Brad H Pollock, Robert A Oster
INTRODUCTION: It is increasingly essential for medical researchers to be literate in statistics, but the requisite degree of literacy is not the same for every statistical competency in translational research. Statistical competency can range from 'fundamental' (necessary for all) to 'specialized' (necessary for only some). In this study, we determine the degree to which each competency is fundamental or specialized. METHODS: We surveyed members of 4 professional organizations, targeting doctorally trained biostatisticians and epidemiologists who taught statistics to medical research learners in the past 5 years...
June 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29029156/detailed-transmission-network-analysis-of-a-large-opiate-driven-outbreak-of-hiv-infection-in-the-united-states
#15
Ellsworth M Campbell, Hongwei Jia, Anupama Shankar, Debra Hanson, Wei Luo, Silvina Masciotra, S Michele Owen, Alexandra M Oster, Romeo R Galang, Michael W Spiller, Sara J Blosser, Erika Chapman, Jeremy C Roseberry, Jessica Gentry, Pamela Pontones, Joan Duwve, Paula Peyrani, Ron M Kagan, Jeannette M Whitcomb, Philip J Peters, Walid Heneine, John T Brooks, William M Switzer
In January 2015, an outbreak of undiagnosed human immunodeficiency virus (HIV) infections among persons who inject drugs (PWID) was recognized in rural Indiana. By September 2016, 205 persons in this community of approximately 4400 had received a diagnosis of HIV infection. We report results of new approaches to analyzing epidemiologic and laboratory data to understand transmission during this outbreak. HIV genetic distances were calculated using the polymerase region. Networks were generated using data about reported high-risk contacts, viral genetic similarity, and their most parsimonious combinations...
November 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28993823/comment-on-glycine-functionalized-copper-ii-hydroxide-nanoparticles-with-high-intrinsic-superoxide-dismutase-activity-by-k-korschelt-r-ragg-c-s-metzger-m-kluenker-m-oster-b-barton-m-panth%C3%A3-fer-d-strand-u-kolb-m-mondeshki-s-strand-j-brieger-m-n-tahir-and-w-tremel
#16
Dieter Lenoir, Karl-Werner Schramm
Detoxification of cigarette smoke employing copper compounds has a potential for the formation of polychlorinated dibenzo-p-dioxins and dibenzofurans and should not be practiced before the degree of formation has been shown to be harmless.
October 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28945855/relationship-of-american-spinal-injury-association-impairment-scale-grade-to-post-injury-hospitalization-and-costs-in-thoracic-spinal-cord-injury
#17
Ellen M Dukes, Steven Kirshblum, Alex A Aimetti, Sarah S Qin, Rebecca K Bornheimer, Gerry Oster
BACKGROUND: The lifetime economic burden of thoracic spinal cord injury (SCI) is known to be high, but evidence of variability of costs in relation to the American Spinal Injury Association Impairment Scale (AIS) grade is limited. OBJECTIVE: To estimate lifetime economic costs of hospitalization by AIS grade in thoracic SCI. METHODS: Using SCI Model Systems data from January 2000 to March 2016 from the National Spinal Cord Injury Statistical Center, we estimated mean total annual days of all-cause hospitalization by AIS grade among persons with thoracic SCI, based on assessments 1, 5, and 10 yr post-injury...
August 9, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28902904/assessing-coastal-wetland-vulnerability-to-sea-level-rise-along-the-northern-gulf-of-mexico-coast-gaps-and-opportunities-for-developing-a-coordinated-regional-sampling-network
#18
Michael J Osland, Kereen T Griffith, Jack C Larriviere, Laura C Feher, Donald R Cahoon, Nicholas M Enwright, David A Oster, John M Tirpak, Mark S Woodrey, Renee C Collini, Joseph J Baustian, Joshua L Breithaupt, Julia A Cherry, Jeremy R Conrad, Nicole Cormier, Carlos A Coronado-Molina, Joseph F Donoghue, Sean A Graham, Jennifer W Harper, Mark W Hester, Rebecca J Howard, Ken W Krauss, Daniel E Kroes, Robert R Lane, Karen L McKee, Irving A Mendelssohn, Beth A Middleton, Jena A Moon, Sarai C Piazza, Nicole M Rankin, Fred H Sklar, Greg D Steyer, Kathleen M Swanson, Christopher M Swarzenski, William C Vervaeke, Jonathan M Willis, K Van Wilson
Coastal wetland responses to sea-level rise are greatly influenced by biogeomorphic processes that affect wetland surface elevation. Small changes in elevation relative to sea level can lead to comparatively large changes in ecosystem structure, function, and stability. The surface elevation table-marker horizon (SET-MH) approach is being used globally to quantify the relative contributions of processes affecting wetland elevation change. Historically, SET-MH measurements have been obtained at local scales to address site-specific research questions...
2017: PloS One
https://www.readbyqxmd.com/read/28902072/hiv-transmission-dynamics-among-foreign-born-persons-in-the-united-states
#19
Eduardo E Valverde, Alexandra M Oster, Songli Xu, Joel O Wertheim, Angela L Hernandez
BACKGROUND: In the United States (US), foreign-born persons are disproportionately affected by HIV and differ epidemiologically from US-born persons with diagnosed HIV infection. Understanding HIV transmission dynamics among foreign-born persons is important to guide HIV prevention efforts for these populations. We conducted molecular transmission network analysis to describe HIV transmission dynamics among foreign-born persons with diagnosed HIV. METHODS: Using HIV-1 polymerase nucleotide sequences reported to the US National HIV Surveillance System for persons with diagnosed HIV infection during 2001-2013, we constructed a genetic distance-based transmission network using HIV-TRACE and examined the birth region of potential transmission partners in this network...
December 15, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28780861/characterization-of-protein-protein-interfaces-in-large-complexes-by-solid-state-nmr-solvent-paramagnetic-relaxation-enhancements
#20
Carl Öster, Simone Kosol, Christoph Hartlmüller, Jonathan M Lamley, Dinu Iuga, Andres Oss, Mai-Liis Org, Kalju Vanatalu, Ago Samoson, Tobias Madl, Józef R Lewandowski
Solid-state NMR is becoming a viable alternative for obtaining information about structures and dynamics of large biomolecular complexes, including ones that are not accessible to other high-resolution biophysical techniques. In this context, methods for probing protein-protein interfaces at atomic resolution are highly desirable. Solvent paramagnetic relaxation enhancements (sPREs) proved to be a powerful method for probing protein-protein interfaces in large complexes in solution but have not been employed toward this goal in the solid state...
September 6, 2017: Journal of the American Chemical Society
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