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https://www.readbyqxmd.com/read/29029156/detailed-transmission-network-analysis-of-a-large-opiate-driven-outbreak-of-hiv-infection-in-the-united-states
#1
Ellsworth M Campbell, Hongwei Jia, Anupama Shankar, Debra Hanson, Wei Luo, Silvina Masciotra, S Michele Owen, Alexandra M Oster, Romeo R Galang, Michael W Spiller, Sara J Blosser, Erika Chapman, Jeremy C Roseberry, Jessica Gentry, Pamela Pontones, Joan Duwve, Paula Peyrani, Ron M Kagan, Jeannette M Whitcomb, Philip J Peters, Walid Heneine, John T Brooks, William M Switzer
In January 2015, an outbreak of undiagnosed human immunodeficiency virus (HIV) infections among persons who inject drugs (PWID) was recognized in rural Indiana. By September 2016, 205 persons in this community of approximately 4400 had received a diagnosis of HIV infection. We report results of new approaches to analyzing epidemiologic and laboratory data to understand transmission during this outbreak. HIV genetic distances were calculated using the polymerase region. Networks were generated using data about reported high-risk contacts, viral genetic similarity, and their most parsimonious combinations...
October 5, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28993823/comment-on-glycine-functionalized-copper-ii-hydroxide-nanoparticles-with-high-intrinsic-superoxide-dismutase-activity-by-k-korschelt-r-ragg-c-s-metzger-m-kluenker-m-oster-b-barton-m-panth%C3%A3-fer-d-strand-u-kolb-m-mondeshki-s-strand-j-brieger-m-n-tahir-and-w-tremel
#2
Dieter Lenoir, Karl-Werner Schramm
Detoxification of cigarette smoke employing copper compounds has a potential for the formation of polychlorinated dibenzo-p-dioxins and dibenzofurans and should not be practiced before the degree of formation has been shown to be harmless.
October 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28945855/relationship-of-american-spinal-injury-association-impairment-scale-grade-to-post-injury-hospitalization-and-costs-in-thoracic-spinal-cord-injury
#3
Ellen M Dukes, Steven Kirshblum, Alex A Aimetti, Sarah S Qin, Rebecca K Bornheimer, Gerry Oster
BACKGROUND: The lifetime economic burden of thoracic spinal cord injury (SCI) is known to be high, but evidence of variability of costs in relation to the American Spinal Injury Association Impairment Scale (AIS) grade is limited. OBJECTIVE: To estimate lifetime economic costs of hospitalization by AIS grade in thoracic SCI. METHODS: Using SCI Model Systems data from January 2000 to March 2016 from the National Spinal Cord Injury Statistical Center, we estimated mean total annual days of all-cause hospitalization by AIS grade among persons with thoracic SCI, based on assessments 1, 5, and 10 yr post-injury...
August 9, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28902904/assessing-coastal-wetland-vulnerability-to-sea-level-rise-along-the-northern-gulf-of-mexico-coast-gaps-and-opportunities-for-developing-a-coordinated-regional-sampling-network
#4
Michael J Osland, Kereen T Griffith, Jack C Larriviere, Laura C Feher, Donald R Cahoon, Nicholas M Enwright, David A Oster, John M Tirpak, Mark S Woodrey, Renee C Collini, Joseph J Baustian, Joshua L Breithaupt, Julia A Cherry, Jeremy R Conrad, Nicole Cormier, Carlos A Coronado-Molina, Joseph F Donoghue, Sean A Graham, Jennifer W Harper, Mark W Hester, Rebecca J Howard, Ken W Krauss, Daniel E Kroes, Robert R Lane, Karen L McKee, Irving A Mendelssohn, Beth A Middleton, Jena A Moon, Sarai C Piazza, Nicole M Rankin, Fred H Sklar, Greg D Steyer, Kathleen M Swanson, Christopher M Swarzenski, William C Vervaeke, Jonathan M Willis, K Van Wilson
Coastal wetland responses to sea-level rise are greatly influenced by biogeomorphic processes that affect wetland surface elevation. Small changes in elevation relative to sea level can lead to comparatively large changes in ecosystem structure, function, and stability. The surface elevation table-marker horizon (SET-MH) approach is being used globally to quantify the relative contributions of processes affecting wetland elevation change. Historically, SET-MH measurements have been obtained at local scales to address site-specific research questions...
2017: PloS One
https://www.readbyqxmd.com/read/28902072/hiv-transmission-dynamics-among-foreign-born-persons-in-the-united-states
#5
Eduardo E Valverde, Alexandra M Oster, Songli Xu, Joel O Wertheim, Angela L Hernandez
BACKGROUND: In the United States (U.S.), foreign-born persons are disproportionately affected by HIV and differ epidemiologically from U.S.-born persons with diagnosed HIV infection. Understanding HIV transmission dynamics among foreign-born persons is important to guide HIV prevention efforts for these populations. We conducted molecular transmission network analysis to describe HIV transmission dynamics among foreign-born persons with diagnosed HIV. METHODS: Using HIV-1 polymerase nucleotide sequences reported to the U...
September 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28780861/characterization-of-protein-protein-interfaces-in-large-complexes-by-solid-state-nmr-solvent-paramagnetic-relaxation-enhancements
#6
Carl Öster, Simone Kosol, Christoph Hartlmüller, Jonathan M Lamley, Dinu Iuga, Andres Oss, Mai-Liis Org, Kalju Vanatalu, Ago Samoson, Tobias Madl, Józef R Lewandowski
Solid-state NMR is becoming a viable alternative for obtaining information about structures and dynamics of large biomolecular complexes, including ones that are not accessible to other high-resolution biophysical techniques. In this context, methods for probing protein-protein interfaces at atomic resolution are highly desirable. Solvent paramagnetic relaxation enhancements (sPREs) proved to be a powerful method for probing protein-protein interfaces in large complexes in solution but have not been employed toward this goal in the solid state...
September 6, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28759967/people-with-dementia-can-learn-compensatory-movement-maneuvers-for%C3%A2-the-sit-to-stand-task-a-randomized-controlled-trial
#7
Christian Werner, Stefanie Wiloth, Nele Christin Lemke, Florian Kronbach, Carl-Philipp Jansen, Peter Oster, Jürgen M Bauer, Klaus Hauer
BACKGROUND: A complex motor skill highly relevant to mobility in everyday life (e.g., sit-to-stand [STS] transfer) has not yet been addressed in studies on motor learning in people with dementia (PwD). OBJECTIVE: To determine whether a dementia-specific motor learning exercise program enables PwD to learn compensatory STS maneuvers commonly taught in geriatric rehabilitation therapy to enhance patients' STS ability. METHODS: Ninety-seven patients with mild-to-moderate dementia (Mini-Mental State Examination: 21...
July 25, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28710114/circadian-rhythm-disruption-impairs-tissue-homeostasis-and-exacerbates-chronic-inflammation-in-the-intestine
#8
René Pagel, Florian Bär, Torsten Schröder, Annika Sünderhauf, Axel Künstner, Saleh M Ibrahim, Stella E Autenrieth, Kathrin Kalies, Peter König, Anthony H Tsang, Dominik Bettenworth, Senad Divanovic, Hendrik Lehnert, Klaus Fellermann, Henrik Oster, Stefanie Derer, Christian Sina
Endogenous circadian clocks regulate 24 h rhythms of physiology and behavior. Circadian rhythm disruption (CRD) is suggested as a risk factor for inflammatory bowel disease. However, the underlying molecular mechanisms remain unknown. Intestinal biopsies from Per1/2 mutant and wild-type (WT) mice were investigated by electron microscopy, immunohistochemistry, and bromodeoxyuridine pulse-chase experiments. TNF-α was injected intraperitoneally, with or without necrostatin-1, into Per1/2 mice or rhythmic and externally desynchronized WT mice to study intestinal epithelial cell death...
July 14, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28687101/increased-pancreatic-cancer-survival-with-greater-lymph-node-retrieval-in-the-national-cancer-data-base
#9
Carlo M Contreras, Chee Paul Lin, Robert A Oster, Sushanth Reddy, Thomas Wang, Selwyn Vickers, Martin Heslin
BACKGROUND: We evaluated the role of lymph node (LN) retrieval in pancreatic adenocarcinoma (PA) patients undergoing pancreaticoduodenectomy (PD). METHODS: We utilized the National Cancer Data Base; Cox regression models and logistic regression models were used for statistical evaluation. RESULTS: We evaluated 26,792 patients with PA who underwent PD. The mean LN retrieved in LN(-) patients was 10.8 vs 14.4 for LN(+) patients (P < 0.0001)...
September 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28686177/the-telomeric-complex-and-metabolic-disease
#10
REVIEW
Henriette Kirchner, Fozia Shaheen, Hannes Kalscheuer, Sebastian M Schmid, Henrik Oster, Hendrik Lehnert
The attrition of telomeres is believed to be a key event not only in mammalian aging, but also in disturbed nutrient sensing, which could lead to numerous metabolic dysfunctions. The current debate focuses mainly on the question whether telomere shortening, e.g., as a heritable trait, may act as a cause or rather represents a consequence of such chronic diseases. This review discusses the damaging events that ultimately may lead or contribute to telomere shortening and can be associated with metabolic diseases...
July 7, 2017: Genes
https://www.readbyqxmd.com/read/28657784/effect-of-emphysema-extent-on-serial-lung-function-in-patients-with-idiopathic-pulmonary-fibrosis
#11
Vincent Cottin, David M Hansell, Nicola Sverzellati, Derek Weycker, Katerina M Antoniou, Mark Atwood, Gerry Oster, Klaus-Uwe Kirchgaessler, Harold R Collard, Athol U Wells
Rationale Patients with idiopathic pulmonary fibrosis and emphysema may have artificially preserved lung volumes. Objectives This post-hoc analysis investigated the relationship between baseline emphysema and fibrosis extents, and pulmonary function changes over 48 weeks. Methods Data were pooled from two Phase III, randomized, double-blind, placebo-controlled trials of interferon γ-1b in idiopathic pulmonary fibrosis (GIPF-001 [NCT00047645]; GIPF-007 [NCT00075998]). Patients with Week 48 data, baseline high-resolution computed tomography images and forced expiratory volume in 1 second/forced vital capacity ratios <0...
June 28, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28637179/is-delayed-surgical-revascularization-in-acute-myocardial-infarction-useful-or-dangerous-new-insights-into-an-old-problem
#12
Philippe Grieshaber, Peter Roth, Lukas Oster, Tobias M Schneider, Gerold Görlach, Bernd Nieman, Andreas Böning
OBJECTIVES: Haemodynamically stable patients admitted for coronary artery bypass grafting in acute myocardial infarction often undergo delayed surgery in order to avoid the risks of emergency surgery. However, initially stable patients undergoing delayed surgery may develop low cardiac output syndrome (LCOS) during the waiting period, which might be a major drawback of this strategy. We aim to define risk factors and clinical consequences of LCOS during the waiting period. METHODS: A total of 530 consecutive patients with acute myocardial infarction (33% non-ST-segment elevation myocardial infarction and 67% ST-segment-elevation myocardial infarction) underwent isolated coronary artery bypass grafting between 2008 and 2013...
June 20, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28593447/predictors-of-near-term-fracture-in-osteoporotic-women-aged-%C3%A2-65%C3%A2-years-based-on-data-from-the-study-of-osteoporotic-fractures
#13
D Weycker, J Edelsberg, R Barron, M Atwood, G Oster, D B Crittenden, A Grauer
Using data from the Study of Osteoporotic Fractures (SOF), several clinical characteristics predictive of near-term (1-year) risk of hip and non-vertebral fracture among elderly osteoporotic women were identified, and a subset of those for hip fracture was incorporated into a risk assessment tool. Additional research is needed to validate study findings. INTRODUCTION: While several risk factors are known to contribute to long-term fracture risk in women with osteoporosis, factors predicting fracture risk over a shorter time horizon, such as over a 1-year period, are less well-established...
June 7, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28574897/description-of-nurse-scientists-in-a-large-health-care-system
#14
M Cynthia Logsdon, Catherine Kleiner, Cynthia A Oster, Claudia DiSabatino Smith, Brenda Bergman-Evans, Jodeena M Kempnich, Felicia Hogan, John Myers
Replicating a research study that described the work of nurse scientists in children's hospitals, the purpose of the study was to describe the role, activities, and outcomes of nurse scientists employed in a national health care organization. The characteristics of nurses filling the nurse scientist role in clinical settings and outcomes associated with the role have not been extensively described. The setting of this study is ideal since the organization includes facilities of various sizes located in rural, urban, and suburban areas in 18 states...
July 2017: Nursing Administration Quarterly
https://www.readbyqxmd.com/read/28538261/physical-activity-and-sleep-quality-in-breast-cancer-survivors-a-randomized-trial
#15
Laura Q Rogers, Kerry S Courneya, Robert A Oster, Philip M Anton, Randall S Robbs, Andres Forero, Edward McAuley
PURPOSE: Data from large randomized controlled trials confirming sleep quality improvements with aerobic physical activity have heretofore been lacking for post-primary treatment breast cancer survivors. Our primary purpose for this report was to determine the effects of a physical activity behavior change intervention, previously reported to significantly increase physical activity behavior, on sleep quality in post-primary treatment breast cancer survivors. METHODS: Post-primary treatment breast cancer survivors (n = 222) were randomized to a 3-month physical activity behavior change intervention (Better Exercise Adherence after Treatment for Cancer [BEAT Cancer]) or usual care...
October 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28535496/the-diagnostic-challenge-of-low-grade-ductal-carcinoma-in-situ
#16
Tracy Onega, Donald L Weaver, Paul D Frederick, Kimberly H Allison, Anna N A Tosteson, Patricia A Carney, Berta M Geller, Gary M Longton, Heidi D Nelson, Natalia V Oster, Margaret S Pepe, Joann G Elmore
BACKGROUND: Diagnostic agreement among pathologists is 84% for ductal carcinoma in situ (DCIS). Studies of interpretive variation according to grade are limited. METHODS: A national sample of 115 pathologists interpreted 240 breast pathology test set cases in the Breast Pathology Study and their interpretations were compared to expert consensus interpretations. We assessed agreement of pathologists' interpretations with a consensus reference diagnosis of DCIS dichotomised into low- and high-grade lesions...
July 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28464705/receipt-and-timing-of-hiv-drug-resistance-testing-in-six-u-s-jurisdictions
#17
Sharoda Dasgupta, H Irene Hall, Angela L Hernandez, M Cheryl Bañez Ocfemia, Neeraja Saduvala, Alexandra M Oster
The Department of Health and Human Services recommends drug resistance testing at linkage to HIV care. Because receipt and timing of testing are not well characterized, we examined testing patterns among persons with diagnosed HIV who are linked to care. Using surveillance data in six jurisdictions for persons aged ≥13 years with HIV infection diagnosed in 2013, we assessed the proportion receiving testing, and among these, the proportion receiving testing at linkage. Multivariable log-binomial regression modeling estimated associations between selected characteristics and receipt of testing (1) overall, and (2) at linkage among those tested...
December 2017: AIDS Care
https://www.readbyqxmd.com/read/28458918/transmission-fitness-of-drug-resistant-hiv-revealed-in-a-surveillance-system-transmission-network
#18
Joel O Wertheim, Alexandra M Oster, Jeffrey A Johnson, William M Switzer, Neeraja Saduvala, Angela L Hernandez, H Irene Hall, Walid Heneine
Test-and-treat programs are central to the global control of HIV, but transmitted drug resistance threatens the effectiveness of these programs. HIV mutations conferring resistance to antiretroviral drugs reduce replicative fitness in vitro, but their effect on propagation in vivo is less understood. Here, we estimate transmission fitness of these mutations in antiretroviral-naïve populations in the U.S. National HIV Surveillance System by comparing their frequency of clustering in a genetic transmission network relative with wild-type viruses...
January 2017: Virus Evolution
https://www.readbyqxmd.com/read/28455551/erratum-to-older-age-at-the-completion-of-linear-growth-is-associated-with-an-increased-risk-of-adult-glioma
#19
Rebecca B Little, L Burt Nabors, Jeffrey J Olson, Zachary J Thompson, Carrie M Rozmeski, Renato V LaRocca, Peter A Forsyth, Reid C Thompson, Robert A Oster, Sajeel A Chowdhary, Kathleen M Egan
No abstract text is available yet for this article.
April 28, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28450120/hiv-acquisition-and-transmission-among-men-who-have-sex-with-men-and-women-what-we-know-and-how-to-prevent-it
#20
Donna Hubbard McCree, Alexandra M Oster, William L Jeffries, Damian J Denson, Ashley C Lima, Hilary Whitman, Wade Ivy, Kirk D Henny
Men who have sex with men and women (MSMW) compose a subset of men who have sex with men (MSM) and represent an estimated 35% of MSM. Research on the HIV risk behaviors of MSMW has largely focused on their behaviors in comparison to men who have sex with men only (MSMO). Results suggest that compared to MSMO, MSMW are less likely to have ever had an HIV test, are at greater risk of being unaware of their HIV infection and are less likely to have encountered HIV prevention activities or materials. Additional research is needed to provide a more comprehensive understanding of the unique sexual behaviors and lived experience of MSMW as a group in order to better inform HIV prevention efforts...
July 2017: Preventive Medicine
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