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https://www.readbyqxmd.com/read/28106759/sex-specific-muscular-maturation-responses-following-prenatal-exposure-to-methylation-related-micronutrients-in-pigs
#1
Michael Oster, Nares Trakooljul, Henry Reyer, Annette Zeyner, Eduard Muráni, Siriluck Ponsuksili, Klaus Wimmers
Supplementation of micronutrients involved in DNA methylation, particularly during pregnancy, is recommended because of its impacts on human health, but further evidence is needed regarding the effects of over-supplementation and differences between sexes. Here, a porcine model was used to assess effects of maternal supplementation with one-carbon-cycle compounds during prenatal and postnatal stages on offspring muscle development. Sows received either a standard diet (CON) or a standard diet supplemented with folate, B6, B12, methionine, choline, and zinc (MET) throughout gestation...
January 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28100970/sickle-cell-disease-with-cyanotic-congenital-heart-disease-long-term-outcomes-in-5-children
#2
Glen J Iannucci, Olufolake A Adisa, Matthew E Oster, Michael McConnell, William T Mahle
Sickle cell disease is a risk factor for cerebrovascular accidents in the pediatric population. This risk is compounded by hypoxemia. Cyanotic congenital heart disease can expose patients to prolonged hypoxemia. To our knowledge, the long-term outcome of patients who have combined sickle cell and cyanotic congenital heart disease has not been reported. We retrospectively reviewed patient records at our institution and identified 5 patients (3 girls and 2 boys) who had both conditions. Their outcomes were uniformly poor: 4 died (age range, 12 mo-17 yr); 3 had documented cerebrovascular accidents; and 3 developed ventricular dysfunction...
December 2016: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/28098064/the-association-of-hyponatremia-risk-of-confusional-state-and-mortality
#3
Tania Zieschang, Marcia Wolf, Tinu Vellappallil, Lorenz Uhlmann, Peter Oster, Daniel Kopf
BACKGROUND: Hyponatremia and delirium are frequent problems in older hospitalized patients. Although confusional states are considered to be a possible complication of hyponatremia, there has been no systematic study to date of the precise prevalence of delirium among patients with hyponatremia and its effect on long-term outcomes. METHODS: In a 13-month period in 2009/2010, all patients with a serum sodium level less than or equal to 130 mmol/L (the hyponatremia group) in a cohort of hospitalized older patients were studied and compared to a normonatremic control group of patients who were matched for age, sex, and diagnosis group...
December 16, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28087238/lymphocyte-circadian-clocks-control-lymph-node-trafficking-and-adaptive-immune-responses
#4
David Druzd, Olga Matveeva, Louise Ince, Ute Harrison, Wenyan He, Christoph Schmal, Hanspeter Herzel, Anthony H Tsang, Naoto Kawakami, Alexei Leliavski, Olaf Uhl, Ling Yao, Leif Erik Sander, Chien-Sin Chen, Kerstin Kraus, Alba de Juan, Sophia Martina Hergenhan, Marc Ehlers, Berthold Koletzko, Rainer Haas, Werner Solbach, Henrik Oster, Christoph Scheiermann
Lymphocytes circulate through lymph nodes (LN) in search for antigen in what is believed to be a continuous process. Here, we show that lymphocyte migration through lymph nodes and lymph occurred in a non-continuous, circadian manner. Lymphocyte homing to lymph nodes peaked at night onset, with cells leaving the tissue during the day. This resulted in strong oscillations in lymphocyte cellularity in lymph nodes and efferent lymphatic fluid. Using lineage-specific genetic ablation of circadian clock function, we demonstrated this to be dependent on rhythmic expression of promigratory factors on lymphocytes...
January 17, 2017: Immunity
https://www.readbyqxmd.com/read/28070770/a-dance-intervention-for-cancer-survivors-and-their-partners-rhythm
#5
Maria Pisu, Wendy Demark-Wahnefried, Kelly M Kenzik, Robert A Oster, Chee Paul Lin, Sharon Manne, Ronald Alvarez, Michelle Y Martin
PURPOSE: The purpose of this study was to assess the feasibility, acceptability, and impact of a ballroom dance intervention on improving quality of life (QOL) and relationship outcomes in cancer survivors and their partners. METHODS: We conducted a pilot randomized controlled trial with two arms (Restoring Health in You (and Your Partner) through Movement, RHYTHM): (1) immediate dance intervention and (2) delayed intervention (wait-list control). The intervention consisted of 10 private weekly dance lessons and 2 practice parties over 12 weeks...
January 9, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28019705/empathic-processes-during-nurse-consumer-conflict-situations-in-psychiatric-inpatient-units-a-qualitative-study
#6
Adam Gerace, Candice Oster, Deb O'Kane, Carly L Hayman, Eimear Muir-Cochrane
Empathy is a central component of nurse-consumer relationships. In the present study, we investigated how empathy is developed and maintained when there is conflict between nurses and consumers, and the ways in which empathy can be used to achieve positive outcomes. Through semistructured interviews, mental health nurses (n = 13) and consumers in recovery (n = 7) reflected on a specific conflict situation where they had experienced empathy, as well as how empathy contributed more generally to working with nurses/consumers...
December 26, 2016: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28017532/discovery-of-triazole-aminopyrazines-as-a-highly-potent-and-selective-series-of-pi3k%C3%AE-inhibitors
#7
Ina Terstiege, Matthew Perry, Jens Petersen, Christian Tyrchan, Tor Svensson, Helena Lindmark, Linda Öster
A novel class of potent PI3Kδ inhibitors with >1000-fold selectivity against other class I PI3K isoforms is described. Optimization of the substituents on a triazole aminopyrazine scaffold, emerging from an in-house PI3Kα program, turned moderately selective PI3Kδ compounds into highly potent and selective PI3Kδ inhibitors. These efforts resulted in a series of aminopyrazines with PI3Kδ IC50⩽1nM in the enzyme assay, some of the most selective PI3Kδ inhibitors published to date, with a cell potency in a JeKo-cell assay of 20-120nM...
November 2, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28005480/hiv-1-infection-and-transmission-networks-of-younger-people-in-chicago-illinois-2005-2011
#8
Ethan Morgan, Alexandra M Oster, Stephanie Townsell, Donna Peace, Nanette Benbow, John A Schneider
OBJECTIVE: Analysis of HIV nucleotide sequences can be used to identify people with highly similar HIV strains and understand transmission patterns. The objective of this study was to identify groups of people highly connected by HIV transmission and the extent to which transmission occurred within and between geographic areas in Chicago, Illinois. METHODS: We analyzed genetic sequences in the HIV-1 pol region in samples collected from people participating in the VARHS program in Chicago during 2005-2011...
January 2017: Public Health Reports
https://www.readbyqxmd.com/read/27986688/male-to-female-sexual-transmission-of-zika-virus-united-states-january-april-2016
#9
Kate Russell, Susan L Hills, Alexandra M Oster, Charsey Cole Porse, Gregory Danyluk, Marshall Cone, Richard Brooks, Sarah Scotland, Elizabeth Schiffman, Carolyn Fredette, Jennifer L White, Katherine Ellingson, Allison Hubbard, Amanda Cohn, Marc Fischer, Paul Mead, Ann M Powers, John T Brooks
We report on 9 cases of male-to-female sexual transmission of Zika virus in the United States occurring January-April 2016. This report summarizes new information about both timing of exposure and symptoms of sexually transmitted Zika virus disease, and results of semen testing for Zika virus from 2 male travelers.
October 19, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27980099/the-biogrid-interaction-database-2017-update
#10
Andrew Chatr-Aryamontri, Rose Oughtred, Lorrie Boucher, Jennifer Rust, Christie Chang, Nadine K Kolas, Lara O'Donnell, Sara Oster, Chandra Theesfeld, Adnane Sellam, Chris Stark, Bobby-Joe Breitkreutz, Kara Dolinski, Mike Tyers
The Biological General Repository for Interaction Datasets (BioGRID: https://thebiogrid.org) is an open access database dedicated to the annotation and archival of protein, genetic and chemical interactions for all major model organism species and humans. As of September 2016 (build 3.4.140), the BioGRID contains 1 072 173 genetic and protein interactions, and 38 559 post-translational modifications, as manually annotated from 48 114 publications. This dataset represents interaction records for 66 model organisms and represents a 30% increase compared to the previous 2015 BioGRID update...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27974893/recoverable-record-high-lactic-acidosis-in-a-patient-with-glycogen-storage-disease-type-1-a-mixed-type-a-and-type-b-lactate-disorder
#11
Yonatan Oster, Isaiah D Wexler, Samuel N Heyman, Elchanan Fried
A 17-year-old patient with GSD type 1a (von Gierke disease) was hospitalized with an extremely elevated serum lactate following an intercurrent infection and interruption of his frequent intake of carbohydrates. The patient developed shock, oliguric renal failure, and cardiorespiratory failure requiring mechanical ventilation and inotropes. At the peak of metabolic decompensation and clinical instability, serum lactate reached a level of 47.6 mmol/L which was accompanied by a severe anion gap metabolic acidosis with a pH of 6...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27972216/phase-iii-trial-of-recombinant-human-parathyroid-hormone-in-hypoparathyroidism-a-post-hoc-analysis-of-change-in-health-state-utility-among-responders
#12
D Weycker, K Chen, M Vera-Llonch, R Bornheimer, G Oster
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27956074/aide-acute-illness-and-depression-in-elderly-patients-cognitive-behavioral-group-psychotherapy-in-geriatric-patients-with-comorbid-depression-a-randomized-controlled-trial
#13
Jana Hummel, Cecilia Weisbrod, Leila Boesch, Katharina Himpler, Klaus Hauer, Martin Hautzinger, Andrea Gaebel, Tania Zieschang, Andrea Fickelscherer, Slawomira Diener, Ilona Dutzi, Bertram Krumm, Peter Oster, Daniel Kopf
BACKGROUND: Comorbid depression is highly prevalent in geriatric patients and associated with functional loss, frequent hospital re-admissions, and a higher mortality rate. Cognitive behavioral psychotherapy (CBT) has shown to be effective in older depressive patients living in the community. To date, CBT has not been applied to older patients with acute physical illness and comorbid depression. OBJECTIVES: To evaluate the effectiveness of CBT in depressed geriatric patients, hospitalized for acute somatic illness...
December 9, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27939495/development-and-impact-of-arrhythmias-after-the-norwood-procedure-a-report-from-the-pediatric-heart-network
#14
Matthew E Oster, Shan Chen, Nicholas Dagincourt, Yaniv Bar-Cohen, Matthew Brothers, Nicole Cain, Steven D Colan, Richard J Czosek, Jamie A Decker, David G Gamboa, Salim F Idriss, Joel A Kirsh, Martin J LaPage, Richard G Ohye, Elizabeth Radojewski, Maully Shah, Eric S Silver, Anoop K Singh, Joel D Temple, John Triedman, Jonathan R Kaltman
OBJECTIVES: The study objective was to determine the predictors of new-onset arrhythmia among infants with single-ventricle anomalies during the post-Norwood hospitalization and the association of those arrhythmias with postoperative outcomes (ventilator time and length of stay) and interstage mortality. METHODS: After excluding patients with preoperative arrhythmias, we used data from the Pediatric Heart Network Single Ventricle Reconstruction Trial to identify risk factors for tachyarrhythmias (atrial fibrillation, atrial flutter, supraventricular tachycardia, junctional ectopic tachycardia, and ventricular tachycardia) and atrioventricular block (second or third degree) among 544 eligible patients...
November 16, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27912209/databases-for-congenital-heart-defect-public-health-studies-across-the-lifespan
#15
REVIEW
Tiffany J Riehle-Colarusso, Lisa Bergersen, Craig S Broberg, Cynthia H Cassell, Darryl T Gray, Scott D Grosse, Jeffrey P Jacobs, Marshall L Jacobs, Russell S Kirby, Lazaros Kochilas, Asha Krishnaswamy, Arianne Marelli, Sara K Pasquali, Thalia Wood, Matthew E Oster
No abstract text is available yet for this article.
October 26, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27894567/proportion-of-selected-congenital-heart-defects-attributable-to-recognized-risk-factors
#16
Regina M Simeone, Sarah C Tinker, Suzanne M Gilboa, A J Agopian, Matthew E Oster, Owen J Devine, Margaret A Honein
PURPOSE: To assess the contribution of multiple risk factors for two congenital heart defects-hypoplastic left heart syndrome (HLHS) and tetralogy of Fallot (TOF). METHODS: We used data from the National Birth Defects Prevention Study (1997-2011) to estimate average adjusted population attributable fractions for several recognized risk factors, including maternal prepregnancy overweight-obesity, pregestational diabetes, age, and infant sex. RESULTS: There were 594 cases of isolated simple HLHS, 971 cases of isolated simple TOF, and 11,829 controls in the analysis...
December 2016: Annals of Epidemiology
https://www.readbyqxmd.com/read/27874252/pediatric-cardiac-readmissions-an-opportunity-for-quality-improvement
#17
Jeffrey H Sacks, Michael Kelleman, Courtney McCracken, Michelle Glanville, Matthew Oster
OBJECTIVE: Hospital readmissions are increasingly becoming a metric for quality in the current landscape of changing and cost effective medicine. However, no 30-d readmission rates have been established for pediatric cardiac medical patients in the United States. Thus, the objective was to determine 30 d readmission rates and risk factors associated with readmission for pediatric cardiac patients, hypothesizing that pediatric cardiac patients would have significantly higher readmission rates than their general pediatric counterparts...
November 22, 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/27870945/erythropoietin-administration-is-associated-with-improved-t-cell-properties-in-patients-with-myelodysplastic-syndromes
#18
Naamit Deshet-Unger, Howard S Oster, Sara Prutchi-Sagiv, Nir Maaravi, Nataliya Golishevski, Drorit Neumann, Moshe Mittelman
The immune system is impaired in myelodysplastic syndromes (MDS) and plays a role in the pathogenesis of the disease. Here we show effects of recombinant human erythropoietin (rHuEPO) on T cell (CD4(+), CD8(+) and CD4(+)CD25(+)) number and function in MDS patients. Healthy (20 subjects), MDS patients without rHuEPO treatment ('MDS', 13), and MDS patients treated with rHuEPO ('MDS+EPO', 17) were examined. CD4(+) and CD8(+) T cell numbers were reduced and increased respectively in MDS compared to healthy subjects...
January 2017: Leukemia Research
https://www.readbyqxmd.com/read/27855999/assessment-of-growth-6-years-after-the-norwood-procedure
#19
Phillip T Burch, Chitra Ravishankar, Jane W Newburger, Linda M Lambert, Victoria L Pemberton, Suzanne Granger, Alejandro A Floh, Jeffrey B Anderson, Garick D Hill, Kevin D Hill, Matthew E Oster, Alan B Lewis, Kurt R Schumacher, Sinai C Zyblewski, Ryan R Davies, Jeffrey P Jacobs, Wyman W Lai, L LuAnn Minich
: At 6 years of age, patients with hypoplastic left heart syndrome had mean age-adjusted z-scores for weight and height below the normative population, and body mass index was similar to the normative population. Males had the greatest increase in z-scores for body mass index. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00115934.
January 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/27831696/neuropsychological-functioning-in-college-students-with-and-without-adhd
#20
Lisa L Weyandt, Danielle R Oster, Bergljot Gyda Gudmundsdottir, George J DuPaul, Arthur D Anastopoulos
Objective: Increasing numbers of students with attention-deficit/hyperactivity disorder (ADHD) are attending college; however, little empirical information is available concerning the functional impairment experienced by these students. Although preliminary studies suggest that college students with ADHD are more likely to experience a variety of psychosocial and academic difficulties compared to their peers without the disorder, findings regarding neuropsychological functioning have been inconsistent with some studies reporting that college students with ADHD perform more poorly on various cognitive and neuropsychological tasks while others report no differences compared to their peers without ADHD...
November 10, 2016: Neuropsychology
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