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https://www.readbyqxmd.com/read/29304874/total-arterial-revascularization-in-patients-with-acute-myocardial-infarction-feasibility-and-outcomes
#1
Philippe Grieshaber, Lukas Oster, Tobias Schneider, Victoria Johnson, Coskun Orhan, Peter Roth, Bernd Niemann, Andreas Böning
BACKGROUND: In acute situations such as acute myocardial infarction (AMI) with indication for coronary artery bypass grafting (CABG), total arterial revascularization (TAR) is often rejected in favour of saphenous vein (SV) grafting, which is assumed to allow for quicker vessel harvesting, a simpler anastomosis technique, and thus quicker revascularization and fewer bleeding complications. The aim of this study was to evaluate whether reluctance to apply TAR in AMI is still justified from a technical point of view in the current era and whether superiority of TAR results is also evident in emergency patients with AMI undergoing CABG...
January 5, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29302752/the-role-of-the-circadian-clock-system-in-physiology
#2
REVIEW
Violetta Pilorz, Charlotte Helfrich-Förster, Henrik Oster
Life on earth is shaped by the 24-h rotation of our planet around its axes. To adapt behavior and physiology to the concurring profound but highly predictable changes, endogenous circadian clocks have evolved that drive 24-h rhythms in invertebrate and vertebrate species. At the molecular level, circadian clocks comprised a set of clock genes organized in a system of interlocked transcriptional-translational feedback loops. A ubiquitous network of cellular central and peripheral tissue clocks coordinates physiological functions along the day through activation of tissue-specific transcriptional programs...
January 4, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29295649/is-bone-marrow-examination-always-necessary-to-establish-the-diagnosis-of-myelodysplastic-syndromes-a-proposed-non-invasive-diagnostic-model
#3
Howard S Oster, Gal Carmi, Alex Kolomansky, Erel Joffe, Irit Kaye, Ilya Kirgner, Uri Greenbaum, Doron Comaneshter, Moshe Mittelman
A non-invasive myelodysplastic syndromes (MDS) diagnostic model would allow for care while avoiding invasive bone marrow examinations (BME). BME-established MDS patients were compared to non-MDS (BME-excluded) patients. Variables (gender, age, hemoglobin (Hb), mean red blood cell corpuscular volume (MCV), platelet (PLT), and white blood cell (WBC)) were combined with multivariate logistic regression; a probability score (Y) was calculated. MDS (n = 48) and non-MDS (n = 63) patients were used to establish the model...
January 2, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29285956/self-management-programs-for-aboriginal-and-torres-strait-islander-peoples-with-chronic-conditions-a-rapid-review
#4
Ellie Moore, Sharon Lawn, Candice Oster, Andrea Morello
Objectives Review the evidence for the effectiveness of chronic condition self-management programs applied to Aboriginal and Torres Strait Islander Peoples. Methods A rapid review methodology was followed to develop an evidence summary from peer-reviewed and grey literature. Results Only seven peer-reviewed studies were identified. The evidence indicated that group programs, particularly the Stanford Program, and structured individual chronic condition self-management programs were of good quality for Aboriginal and Torres Strait Islander Peoples, although these need to be integrated into practice in order to see the greatest benefits...
January 1, 2017: Chronic Illness
https://www.readbyqxmd.com/read/29284431/the-health-and-wellbeing-needs-of-veterans-a-rapid-review
#5
Candice Oster, Andrea Morello, Anthony Venning, Paula Redpath, Sharon Lawn
BACKGROUND: For the majority of serving members, life in the military has a positive effect on wellbeing. However, the type, intensity and duration of service, along with the transition from fulltime military to civilian life, may have a negative effect on veterans' wellbeing. Such negative consequences, alongside the growing veteran population, indicate the need for greater exploration of veterans' physical, mental and social wellbeing. METHODS: The current paper reports on the findings of a rapid review of the literature on the health and wellbeing needs of veterans, commissioned by the Australian Department of Veterans' Affairs to inform future programs and services...
December 29, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29247922/analysis-of-meat-quality-traits-and-gene-expression-profiling-of-pigs-divergent-in-residual-feed-intake
#6
Justyna Horodyska, Michael Oster, Henry Reyer, Anne Maria Mullen, Peadar G Lawlor, Klaus Wimmers, Ruth M Hamill
Residual feed intake (RFI), the difference between actual feed intake and predicted feed requirements, is suggested to impact various aspects of meat quality. The objective of this study was to investigate the molecular mechanisms underpinning the relationship between RFI and meat quality. Technological, sensory and nutritional analysis as well as transcriptome profiling were carried out in Longissimus thoracis et lumborum muscle of pigs divergent in RFI (n=20). Significant differences in sensory profile and texture suggest a minor impairment of meat quality in more efficient pigs...
November 20, 2017: Meat Science
https://www.readbyqxmd.com/read/29224668/circadian-clock-gastrointestinal-peptide-interaction-in-peripheral-tissues-and-the-brain
#7
REVIEW
Dominic Landgraf, Anne-Marie Neumann, Henrik Oster
Food intake and sleep are two mutually exclusive behaviors and both are normally confined to opposing phases of the diurnal cycle. The temporal coordination of behavior and physiology along the 24-h day-night cycle is organized by a network of circadian clocks that orchestrate transcriptional programs controlling cellular physiology. Many of the peptide hormones of the gastrointestinal tract are not only secreted in a circadian fashion, they can also affect circadian clock function in peripheral metabolic tissues and the brain, thus providing metabolic feedback to metabolic and neurobehavioral circuits...
December 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29219911/practical-application-of-high-reliability-principles-in-healthcare-to-optimize-quality-and-safety-outcomes
#8
Cynthia A Oster, Sherilyn Deakins
Application of high-reliability (HR) principles into daily healthcare processes can drive culture change, safety, and quality outcomes. Understanding foundational practices to full HR principle integration in an organization's quality and safety programs strengthens evidence-based practices, reduces clinical variation, and improves nurse-sensitive patient outcomes. Quantifying the cost impact of reduction in preventable harm and improved nurse-sensitive patient outcomes is an initial attempt to formulate an empiric measure of nursing value...
January 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29209720/association-of-us-state-implementation-of-newborn-screening-policies-for-critical-congenital-heart-disease-with-early-infant-cardiac-deaths
#9
Rahi Abouk, Scott D Grosse, Elizabeth C Ailes, Matthew E Oster
Importance: In 2011, critical congenital heart disease was added to the US Recommended Uniform Screening Panel for newborns, but whether state implementation of screening policies has been associated with infant death rates is unknown. Objective: To assess whether there was an association between implementation of state newborn screening policies for critical congenital heart disease and infant death rates. Design, Setting, and Participants: Observational study with group-level analyses...
December 5, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29192318/the-influence-of-target-and-masker-characteristics-on-infants-and-adults-detection-of-speech
#10
Monika-Maria Oster, Lynne A Werner
Purpose: Several investigators have compared infants' detection of speech in speech and nonspeech maskers to evaluate developmental differences in masking. Such comparisons have produced contradictory results, possibly because each investigation used different stimuli. The current study examined target and masker effects on infants' and adults' detection of speech. Method: An observer-based procedure was used to compare infants' and adults' detection of the vowel /ʌ/ and the word "baby" in a 2-talker speech masker and matched speech-spectrum noise...
November 29, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29182938/does-disease-cause-vaccination-disease-outbreaks-and-vaccination-response
#11
Emily Oster
Parental fear of vaccines has limited vaccination rates in the United States. I test whether disease outbreaks increase vaccination using a new dataset of county-level disease and vaccination data. I find that pertussis (whooping cough) outbreaks in a county decrease the share of unvaccinated children entering kindergarten. These responses do not reflect changes in the future disease risk. I argue that these facts are best fit by a model in which individuals are both myopic and irrational. This suggests that better promotion of information about outbreaks could enhance the response...
November 2, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/29178324/effect-of-lsr-polymorphism-on-blood-lipid-levels-and-age-specific-epistatic-interaction-with-the-apoe-common-polymorphism
#12
T Xie, M G Stathopoulou, S Akbar, T Oster, G Siest, F T Yen, S Visvikis-Siest
The lipolysis stimulated lipoprotein receptor (LSR) is an apolipoprotein (Apo) B and ApoE receptor that participates in the removal of TG-rich lipoproteins during the postprandial phase. LSR gene is located upstream of APOE, an important risk factor for cardiovascular disease (CVD). Since the APOE common polymorphism significantly affects the variability of lipid metabolism, this study aimed to determine the potential impact of a functional SNP rs916147 in LSR gene on lipid traits in healthy subjects and to investigate potential epistatic interaction between LSR and APOE...
November 27, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/29176448/patients-experiences-of-using-a-cellular-photo-digital-breathalyzer-for-treatment-purposes
#13
Christina Nehlin, Kristina Carlsson, Caisa Öster
OBJECTIVES: The field of eHealth systems is rapidly developing and is now expanding into alcohol treatment settings. Despite a growing public and professional interest, cellular photo digital breathalyzers (CPDBs) have not been investigated in a clinical context so far. In this study, we aimed to investigate the experiences of patients in alcohol treatment who had been using a CPDB-TripleA- for a minimum of three months. What are their personal experiences of using the CPDB? Do the patients think it supports them to change their drinking habits, and if so, in what way? METHODS: A qualitative interview study with individuals who had been using the CPDB TripleA, for at least 3 months as complement to treatment (12-step program or hospital-based outpatient care)...
November 23, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29160614/attention-deficit-hyperactivity-disorder-clinical-considerations-for-women
#14
REVIEW
Marisa E Marraccini, Lisa L Weyandt, Bergljot Gyda Gudmundsdottir, Danielle R Oster, Alison McCallum
Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by hyperactivity, impulsivity, and/or inattention. Women with ADHD represent a particularly vulnerable group, given their increased risk for psychosocial and parenting difficulties. Women's health care clinicians should expect to encounter women with diagnosed and undiagnosed ADHD that may or may not be treated. Pharmacologic intervention, namely, prescription stimulants, is an important consideration for pregnant and breastfeeding women with ADHD, especially because the US Food and Drug Administration has determined that there is not enough information to confirm either harm or lack of harm to the developing fetus following exposure to these drugs...
November 21, 2017: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/29159450/lower-dietary-phosphorus-supply-in-pigs-match-both-animal-welfare-aspects-and-resource-efficiency
#15
Michael Oster, Christian Gerlinger, Kaja Heide, Franziska Just, Luisa Borgelt, Petra Wolf, Christian Polley, Brigitte Vollmar, Eduard Muráni, Siriluck Ponsuksili, Klaus Wimmers
Dietary phosphorus frequently exceeds age-specific requirements and pig manure often contains high phosphorus load which causes environmental burden at regional scales. Therefore, feeding strategies towards improved phosphorus efficiency and reduced environmental phosphorus load have to be developed. A 5-week feeding trial was conducted: piglets received medium, lower (-25%), or higher (+25%) amounts of phosphorus and calcium. Dietary responses were reflected by performance parameters, bone characteristics, and molecular data retrieved from serum, intestinal mucosa, and kidney cortex (p < 0...
November 20, 2017: Ambio
https://www.readbyqxmd.com/read/29157092/single-agent-and-synergistic-combinatorial-efficacy-of-first-in-class-small-molecule-imipridone-onc201-in-hematological-malignancies
#16
Varun V Prabhu, Mala K Talekar, Amriti R Lulla, C Leah B Kline, Lanlan Zhou, Junior Hall, A Pieter J Van den Heuvel, David T Dicker, Jawad Babar, Stephan A Grupp, Mathew J Garnett, Ultan McDermott, Cyril H Benes, Jeffrey J Pu, David F Claxton, Nadia Khan, Wolfgang Oster, Joshua E Allen, Wafik S El-Deiry
ONC201, founding member of the imipridone class of small molecules, is currently being evaluated in advancer cancer clinical trials. We explored single agent and combinatorial efficacy of ONC201 in preclinical models of hematological malignancies. ONC201 demonstrated (GI50 1-8 µM) dose- and time-dependent efficacy in acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML), chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), Burkitt's lymphoma, anaplastic large cell lymphoma (ALCL), cutaneous T-cell lymphoma (CTCL), Hodgkin's lymphoma (nodular sclerosis) and multiple myeloma (MM) cell lines including cells resistant to standard of care (dexamethasone in MM) and primary samples...
November 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/29154494/interplay-between-environmentally-modulated-feedback-loops-hypoxia-and-circadian-rhythms-two-sides-of-the-same-coin
#17
Reinhard Depping, Henrik Oster
Sensing of environmental parameters is critically important for cells of metazoan organisms. Members of the superfamily of bHLH-PAS transcription factors, involved in oxygen sensing and circadian rhythm generation, are important players in such molecular pathways. The interplay between both networks includes a so far unknown factor, connecting PER2 (circadian clocks) to hypoxia sensing (HIF-1 α) to result in a more adapted state of homeostasis at the right time.
November 2017: FEBS Journal
https://www.readbyqxmd.com/read/29153758/will-use-of-patient-portals-help-to-educate-and-communicate-with-patients-with-diabetes
#18
Sara L Jackson, Catherine M DesRoches, Dominick L Frosch, Sue Peacock, Natalia V Oster, Joann G Elmore
OBJECTIVE: Chronic disease management can require daily attention, and increased levels of patient activation and engagement. We examined whether patients with diabetes perceive a greater benefit to having electronic access to their doctors' clinic notes compared to patients without diabetes. We hypothesized that easy electronic access to these notes may help patients with self-care by improving education and communication. METHODS: Survey of patients with and without diabetes in Massachusetts and Pennsylvania about perceptions of potential benefits and risks of reading their visit notes via an electronic patient information portal...
November 8, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/29150179/-therapeutic-strategies-in-patients-undergoing-surgery-for-non-small-cell-lung-cancer-results-of-the-escap-2011-cphg-study-promoted-by-the-french-college-of-general-hospital-respiratory-physicians-cphg
#19
F Pinquié, F Goupil, J-P Oster, A Dixmier, P-A Renault, A Lévy, J-P Mathieu, N Paillot, F C Goutorbe, P Masson, O Molinier, D Debieuvre, M Grivaux
BACKGROUND: The aim of ESCAP-2011-CPHG, promoted by the French College of General Hospital Respiratory Physicians, was to describe therapeutic strategies in lung cancer in the first 2 years after diagnosis, in a real-life setting. This article focuses on patients undergoing surgical management of a non-small cell lung cancer (NSCLC). METHODS: A prospective multicentre study was conducted in 53 French general hospitals. For each patient with lung cancer diagnosed in 2010, a standardised form was completed following each change in treatment strategy up to 2 years after diagnosis...
November 14, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29145646/review-of-dose-rate-effects-in-the-thermoluminescence-of-lif-mg-ti-harshaw
#20
Yigal Horowitz, Leonid Oster, Ilan Eliyahu
The literature describing the experimental investigations of possible dose-rate effects in the thermoluminescence (TL) of LiF:Mg,Ti (Harshaw) is reviewed. The total lack of glow curve analysis, coupled with inclusion of all or part of the high temperature TL and absence of parallel measurements of possible dose-rate effects in the irradiation stage severely limit the scientific and technical level of the experiments. In addition, the experimental procedures are far from sufficient to warrant any conclusion concerning the presence or absence of dose-rate effects in the TL of LiF:Mg,Ti...
November 14, 2017: Radiation Protection Dosimetry
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