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https://www.readbyqxmd.com/read/28794892/the-use-of-non-invasive-fetal-electrocardiography-in-diagnosing-second-degree-fetal-atrioventricular-block
#1
Igor Lakhno, Joachim A Behar, Julien Oster, Vyacheslav Shulgin, Oleksii Ostras, Fernando Andreotti
BACKGROUND: Complete atrioventricular block in fetuses is known to be mostly associated with autoimmune disease and can be irreversible if no steroids treatment is provided. Conventional methods used in clinical practice for diagnosing fetal arrhythmia are limited since they do not reflect the primary electrophysiological conduction processes that take place in the myocardium. The non-invasive fetal electrocardiogram has the potential to better support fetal arrhythmias diagnosis through the continuous analysis of the beat to beat variation of the fetal heart rate and morphological analysis of the PQRST complex...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/28780861/characterization-of-protein-protein-interfaces-in-large-complexes-by-solid-state-nmr-solvent-paramagnetic-relaxation-enhancements
#2
Carl Öster, Simone Kosol, Christoph Hartlmüller, Jonathan M Lamley, Dinu Iuga, Andres Oss, Mai-Liis Org, Kalju Vanatalu, Ago Samoson, Tobias Madl, Józef R Lewandowski
Solid-state NMR is becoming a viable alternative for obtaining information about structures and dynamics of large biomolecular complexes including ones that are not accessible to other high resolution biophysical techniques. In this context, methods for probing protein-protein interfaces at atomic resolution are highly desirable. Solvent paramagnetic relaxation enhancements (sPREs) proved to be a powerful method for probing protein-protein interfaces in large complexes in solution but have not been employed towards this goal in the solid state...
August 7, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28763040/strategies-towards-improved-feed-efficiency-in-pigs-comprise-molecular-shifts-in-hepatic-lipid-and-carbohydrate-metabolism
#3
Henry Reyer, Michael Oster, Elizabeth Magowan, Dirk Dannenberger, Siriluck Ponsuksili, Klaus Wimmers
Due to the central role of liver tissue in partitioning and metabolizing of nutrients, molecular liver-specific alterations are of considerable interest to characterize an efficient conversion and usage of feed in livestock. To deduce tissue-specific and systemic effects on nutrient metabolism and feed efficiency (FE) twenty-four animals with extreme phenotypes regarding residual feed intake (RFI) were analyzed. Transcriptome and fatty acid profiles of liver tissue were complemented with measurements on blood parameters and thyroid hormone levels...
August 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28759967/people-with-dementia-can-learn-compensatory-movement-maneuvers-for%C3%A2-the-sit-to-stand-task-a-randomized-controlled-trial
#4
Christian Werner, Stefanie Wiloth, Nele Christin Lemke, Florian Kronbach, Carl-Philipp Jansen, Peter Oster, Jürgen M Bauer, Klaus Hauer
BACKGROUND: A complex motor skill highly relevant to mobility in everyday life (e.g., sit-to-stand [STS] transfer) has not yet been addressed in studies on motor learning in people with dementia (PwD). OBJECTIVE: To determine whether a dementia-specific motor learning exercise program enables PwD to learn compensatory STS maneuvers commonly taught in geriatric rehabilitation therapy to enhance patients' STS ability. METHODS: Ninety-seven patients with mild-to-moderate dementia (Mini-Mental State Examination: 21...
July 25, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28751774/the-assembly-competence-domain-is-essential-for-inv-16-associated-acute-myeloid-leukemia
#5
H-G Kim, J LeGrand, C S Swindle, H J Nick, R A Oster, D Chen, S Purohit-Ghelani, C V Cotta, R Ko, L Gartland, V Reddy, S W Hiebert, A D Friedman, C A Klug
Leukemia accepted article preview online, 28 July 2017. doi:10.1038/leu.2017.236.
July 28, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28731493/lower-extremity-dialysis-arteriovenous-graft-patency-preservation-due-to-traumatic-fistula-to-adjacent-vein
#6
Michael Oster, Offer Galili, Alicia Nachtigal, Dan Hebron
No abstract text is available yet for this article.
July 20, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28710114/circadian-rhythm-disruption-impairs-tissue-homeostasis-and-exacerbates-chronic-inflammation-in-the-intestine
#7
René Pagel, Florian Bär, Torsten Schröder, Annika Sünderhauf, Axel Künstner, Saleh M Ibrahim, Stella E Autenrieth, Kathrin Kalies, Peter König, Anthony H Tsang, Dominik Bettenworth, Senad Divanovic, Hendrik Lehnert, Klaus Fellermann, Henrik Oster, Stefanie Derer, Christian Sina
Endogenous circadian clocks regulate 24 h rhythms of physiology and behavior. Circadian rhythm disruption (CRD) is suggested as a risk factor for inflammatory bowel disease. However, the underlying molecular mechanisms remain unknown. Intestinal biopsies from Per1/2 mutant and wild-type (WT) mice were investigated by electron microscopy, immunohistochemistry, and bromodeoxyuridine pulse-chase experiments. TNF-α was injected intraperitoneally, with or without necrostatin-1, into Per1/2 mice or rhythmic and externally desynchronized WT mice to study intestinal epithelial cell death...
July 14, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28700333/onc201-selectively-induces-apoptosis-in-cutaneous-t-cell-lymphoma-cells-via-activating-pro-apoptotic-integrated-stress-response-and-inactivating-jak-stat-and-nf-%C3%AE%C2%BAb-pathways
#8
Xiao Ni, Xiang Zhang, Cheng-Hui Hu, Timothy Langridge, Rohinton S Tarapore, Joshua E Allen, Wolfgang Oster, Madeleine Duvic
Cutaneous T-cell lymphomas (CTCLs) are extremely symptomatic and still incurable, and more effective and less toxic therapies are urgently needed. ONC201, an imipridone compound, has shown efficacy in pre-clinical studies in multiple advanced cancers. This study was to evaluate the anti-tumor activity of ONC201 on CTCL cells. The effect of ONC201 on the cell growth and apoptosis were evaluated in CTCL cell lines (n=8) and primary CD4+ malignant T cells isolated from CTCL patients (n=5). ONC201 showed a time-dependent cell growth inhibition in all treated cell lines with a concentration range of 1...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28687101/increased-pancreatic-cancer-survival-with-greater-lymph-node-retrieval-in-the-national-cancer-data-base
#9
Carlo M Contreras, Chee Paul Lin, Robert A Oster, Sushanth Reddy, Thomas Wang, Selwyn Vickers, Martin Heslin
BACKGROUND: We evaluated the role of lymph node (LN) retrieval in pancreatic adenocarcinoma (PA) patients undergoing pancreaticoduodenectomy (PD). METHODS: We utilized the National Cancer Data Base; Cox regression models and logistic regression models were used for statistical evaluation. RESULTS: We evaluated 26,792 patients with PA who underwent PD. The mean LN retrieved in LN(-) patients was 10.8 vs 14.4 for LN(+) patients (P < 0.0001)...
July 1, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28686177/the-telomeric-complex-and-metabolic-disease
#10
REVIEW
Henriette Kirchner, Fozia Shaheen, Hannes Kalscheuer, Sebastian M Schmid, Henrik Oster, Hendrik Lehnert
The attrition of telomeres is believed to be a key event not only in mammalian aging, but also in disturbed nutrient sensing, which could lead to numerous metabolic dysfunctions. The current debate focuses mainly on the question whether telomere shortening, e.g., as a heritable trait, may act as a cause or rather represents a consequence of such chronic diseases. This review discusses the damaging events that ultimately may lead or contribute to telomere shortening and can be associated with metabolic diseases...
July 7, 2017: Genes
https://www.readbyqxmd.com/read/28657784/effect-of-emphysema-extent-on-serial-lung-function-in-patients-with-idiopathic-pulmonary-fibrosis
#11
Vincent Cottin, David M Hansell, Nicola Sverzellati, Derek Weycker, Katerina M Antoniou, Mark Atwood, Gerry Oster, Klaus-Uwe Kirchgaessler, Harold R Collard, Athol U Wells
Rationale Patients with idiopathic pulmonary fibrosis and emphysema may have artificially preserved lung volumes. Objectives This post-hoc analysis investigated the relationship between baseline emphysema and fibrosis extents, and pulmonary function changes over 48 weeks. Methods Data were pooled from two Phase III, randomized, double-blind, placebo-controlled trials of interferon γ-1b in idiopathic pulmonary fibrosis (GIPF-001 [NCT00047645]; GIPF-007 [NCT00075998]). Patients with Week 48 data, baseline high-resolution computed tomography images and forced expiratory volume in 1 second/forced vital capacity ratios <0...
June 28, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28637179/is-delayed-surgical-revascularization-in-acute-myocardial-infarction-useful-or-dangerous-new-insights-into-an-old-problem
#12
Philippe Grieshaber, Peter Roth, Lukas Oster, Tobias M Schneider, Gerold Görlach, Bernd Nieman, Andreas Böning
OBJECTIVES: Haemodynamically stable patients admitted for coronary artery bypass grafting in acute myocardial infarction often undergo delayed surgery in order to avoid the risks of emergency surgery. However, initially stable patients undergoing delayed surgery may develop low cardiac output syndrome (LCOS) during the waiting period, which might be a major drawback of this strategy. We aim to define risk factors and clinical consequences of LCOS during the waiting period. METHODS: A total of 530 consecutive patients with acute myocardial infarction (33% non-ST-segment elevation myocardial infarction and 67% ST-segment-elevation myocardial infarction) underwent isolated coronary artery bypass grafting between 2008 and 2013...
June 20, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28634410/climate-response-to-the-8-2-ka-event-in-coastal-california
#13
Jessica L Oster, Warren D Sharp, Aaron K Covey, Jansen Gibson, Bruce Rogers, Hari Mix
A fast-growing stalagmite from the central California coast provides a high-resolution record of climatic changes synchronous with global perturbations resulting from the catastrophic drainage of proglacial Lake Agassiz at ca. 8.2 ka. High frequency, large amplitude variations in carbon isotopes during the 8.2 ka event, coupled with pulsed increases in phosphorus concentrations, indicate more frequent or intense winter storms on the California coast. Decreased magnesium-calcium ratios point toward a sustained increase in effective moisture during the event, however the magnitude of change in Mg/Ca suggests this event was not as pronounced on the western North American coast as anomalies seen in the high northern latitudes and monsoon-influenced areas...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28628488/falls-and-physical-activity-in-persons-with-mild-to-moderate-dementia-participating-in-an-intensive-motor-training-randomized-controlled-trial
#14
Tania Zieschang, Michael Schwenk, Clemens Becker, Lorenz Uhlmann, Peter Oster, Klaus Hauer
BACKGROUND: Physical activity is beneficial in people with dementia. As physical activity increases risk exposure for falls, safety concerns arise. Prior exercise trials in people with dementia have not measured physical activity. Falls in relation to exposure time rather than person-years as outcome measure has been promoted but not investigated in people with dementia. METHODS: Patients with mild to moderate dementia (n=110) were randomized to an intensive, progressive strength and functional training intervention or to a low-intensity group training for 12 weeks each...
June 16, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28598757/exudates-absorption-and-proteases-trapping-in-venous-leg-ulcers
#15
P Humbert, C Courderot-Masuyer, S Robin, D Oster, R Pegahi
OBJECTIVE: In venous leg ulcer (VLU), the impaired healing has been shown to be associated with excessive levels of protease activities such as matrix metalloproteinases (MMPs) and elastases found in exudates. The present study focused on exudates absorption and proteases trapping capacity of a new generation of polyacrylate superabsorbent, Tegaderm superabsorber (TS), compared with a traditional dressing such as Zetuvit. METHOD: We studied the proteases implicated in VLU (MMP-1, MMP-2, MMP-9 and PMN elastase)...
June 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28593447/predictors-of-near-term-fracture-in-osteoporotic-women-aged-%C3%A2-65%C3%A2-years-based-on-data-from-the-study-of-osteoporotic-fractures
#16
D Weycker, J Edelsberg, R Barron, M Atwood, G Oster, D B Crittenden, A Grauer
Using data from the Study of Osteoporotic Fractures (SOF), several clinical characteristics predictive of near-term (1-year) risk of hip and non-vertebral fracture among elderly osteoporotic women were identified, and a subset of those for hip fracture was incorporated into a risk assessment tool. Additional research is needed to validate study findings. INTRODUCTION: While several risk factors are known to contribute to long-term fracture risk in women with osteoporosis, factors predicting fracture risk over a shorter time horizon, such as over a 1-year period, are less well-established...
June 7, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28580282/hepatic-gene-therapy-rescues-high-fat-diet-responses-in-circadian-clock-mutant-mice
#17
Judit Meyer-Kovac, Isa Kolbe, Lea Ehrhardt, Alexei Leliavski, Jana Husse, Gabriela Salinas, Thomas Lingner, Anthony H Tsang, Johanna L Barclay, Henrik Oster
OBJECTIVE: Circadian Clock gene mutant mice show dampened 24-h feeding rhythms and an increased sensitivity to high-fat diet (HFD) feeding. Restricting HFD access to the dark phase counteracts its obesogenic effect in wild-type mice. The extent to which altered feeding rhythms are causative for the obesogenic phenotype of Clock mutant mice, however, remains unknown. METHODS: Metabolic parameters of wild-type (WT) and Clock(Δ19) mutant mice (MT) were investigated under ad libitum and nighttime restricted HFD feeding...
June 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28574928/clinical-and-economic-burden-of-peristomal-skin-complications-in-patients-with-recent-ostomies
#18
Charu Taneja, Debra Netsch, Bonnie Sue Rolstad, Gary Inglese, Lois Lamerato, Gerry Oster
PURPOSE: The purpose of this study was to estimate the risk and economic burden of peristomal skin complications (PSCs) in a large integrated healthcare system in the Midwestern United States. DESIGN: Retrospective cohort study. SUBJECTS AND SETTING: The sample comprised 128 patients; 40% (n = 51) underwent colostomy, 50% (n = 64) underwent ileostomy, and 10% (n = 13) underwent urostomy. Their average age was 60.6 ± 15.6 years at the time of ostomy surgery...
July 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28574897/description-of-nurse-scientists-in-a-large-health-care-system
#19
M Cynthia Logsdon, Catherine Kleiner, Cynthia A Oster, Claudia DiSabatino Smith, Brenda Bergman-Evans, Jodeena M Kempnich, Felicia Hogan, John Myers
Replicating a research study that described the work of nurse scientists in children's hospitals, the purpose of the study was to describe the role, activities, and outcomes of nurse scientists employed in a national health care organization. The characteristics of nurses filling the nurse scientist role in clinical settings and outcomes associated with the role have not been extensively described. The setting of this study is ideal since the organization includes facilities of various sizes located in rural, urban, and suburban areas in 18 states...
July 2017: Nursing Administration Quarterly
https://www.readbyqxmd.com/read/28570048/aerosol-mass-spectrometer-for-simultaneous-detection-of-polyaromatic-hydrocarbons-and-inorganic-components-from-individual-particles
#20
Johannes Passig, Julian Schade, Markus Oster, Matthias Fuchs, Sven Ehlert, Cornelia Jäger, Martin Sklorz, Ralf Zimmermann
Online studies of single airborne particles represent a demanding challenge in aerosol chemistry. New technologies that help to unravel the role of ambient aerosols in earth climate and to assess local and specific health risks from air pollution are highly desired. Of particular relevance are polycyclic aromatic hydrocarbons (PAHs) from combustion processes that are associated with both acute and long-term health effects. Usually, online single particle analyses apply laser desorption/ionization (LDI) in a bipolar mass spectrometer, revealing elemental constituents and limited molecular information by detection of both positive and negative ions...
June 9, 2017: Analytical Chemistry
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