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https://www.readbyqxmd.com/read/28548455/liminality-in-the-occupational-identity-of-mental-health-peer-support-workers-a-qualitative-study
#1
Alan Simpson, Candice Oster, Eimear Muir-Cochrane
Peer support is increasingly provided as a component of mental health care, where people in recovery from mental health problems use their lived experiences to provide support to those experiencing similar difficulties. In the present study, we explored the evolution of peer support workers' (PSW) occupational identities. A qualitative study was undertaken alongside a pilot randomized, controlled trial of peer support for service users discharged from a mental hospital in London, UK. Two focus groups were conducted with eight PSW...
May 26, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28538261/physical-activity-and-sleep-quality-in-breast-cancer-survivors-a-randomized-trial
#2
Laura Q Rogers, Kerry S Courneya, Robert A Oster, Philip M Anton, Randall S Robbs, Andres Forero, Edward McAuley
PURPOSE: Data from large randomized controlled trials confirming sleep quality improvements with aerobic physical activity have heretofore been lacking for post-primary treatment breast cancer survivors. Our primary purpose for this report was to determine the effects of a physical activity behavior change intervention, previously reported to significantly increase physical activity behavior, on sleep quality in post-primary treatment breast cancer survivors. METHODS: Post-primary treatment breast cancer survivors (n=222) were randomized to a 3-month physical activity behavior change intervention (BEAT Cancer) or usual care...
May 20, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28535496/the-diagnostic-challenge-of-low-grade-ductal-carcinoma-in-situ
#3
Tracy Onega, Donald L Weaver, Paul D Frederick, Kimberly H Allison, Anna N A Tosteson, Patricia A Carney, Berta M Geller, Gary M Longton, Heidi D Nelson, Natalia V Oster, Margaret S Pepe, Joann G Elmore
BACKGROUND: Diagnostic agreement among pathologists is 84% for ductal carcinoma in situ (DCIS). Studies of interpretive variation according to grade are limited. METHODS: A national sample of 115 pathologists interpreted 240 breast pathology test set cases in the Breast Pathology Study and their interpretations were compared to expert consensus interpretations. We assessed agreement of pathologists' interpretations with a consensus reference diagnosis of DCIS dichotomised into low- and high-grade lesions...
May 20, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28523852/preparing-adolescents-with-heart-problems-for-transition-to-adult-care-2009-2010-national-survey-of-children-with-special-health-care-needs
#4
Karrie F Downing, Matthew E Oster, Sherry L Farr
OBJECTIVE: A substantial percentage of children with congenital heart disease (CHD) fail to transfer to adult care, resulting in increased risk of morbidity and mortality. Transition planning discussions with a provider may increase rates of transfer, yet little is known about frequency and content of these discussions. We assessed prevalence and predictors of transition-related discussions between providers and parents of children with special healthcare needs (CSHCN) and heart problems, including CHD...
May 19, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28520415/design-and-synthesis-of-soluble-and-cell-permeable-pi3k%C3%AE-inhibitors-for-long-acting-inhaled-administration
#5
Matthew W D Perry, Karin Björhall, Britta K Bonn, Johan Carlsson, Yunhua Chen, Anders Eriksson, Linda Fredlund, Hai'e Hao, Neil S Holden, Kostas Karabelas, Helena Lindmark, Feifei Liu, Nils Pemberton, Jens Petersen, Sandra Rodrigo Blomqvist, Reed W Smith, Tor Svensson, Ina Terstiege, Christian Tyrchan, Wenzhen Yang, Shuchun Zhao, Linda Öster
PI3Kδ is a lipid kinase that is believed to be important in the migration and activation of cells of the immune system. Inhibition is hypothesised to provide a powerful yet selective immunomodulatory effect that may be beneficial for the treatment of conditions such as asthma or rheumatoid arthritis. In this work we describe the identification of inhibitors based on a thiazolopyridone core structure and their subsequent optimisation for inhalation. The initially identified compound (13) had good potency and isoform selectivity but was not suitable for inhalation...
May 18, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28493245/-the-prognostic-significance-of-icf-data-with-regard-to-realization-of-recommendations-given-in-the-medical-discharge-report-after-in-patient-psychosomatic-rehabilitation
#6
Jörg Oster, Jörn von Wietersheim, Gottfried Müller, Carina Braunger
Target In this trial, the prognostic significance of ICF-related diagnostics compared to social and medical, disease-related and personal factors with regard to realization of recommendations given in the medical discharge report after the in-patient psychosomatic rehabilitation should be examined. Methodology ICF-related, social and medical, disease-related and personal prognostic factors were surveyed by questionnaires and interviews, on admission, discharge and 6 months after discharge from rehabilitation (time of catamnesis)...
May 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28489985/preclinical-evaluation-of-the-imipridone-family-analogues-of-clinical-stage-anti-cancer-small-molecule-onc201-reveals-potent-anti-cancer-effects-of-onc212
#7
Jessica Wagner, Christina Leah Kline, Marie D Ralff, Avital Lev, Amriti Lulla, Lanlan Zhou, Gary L Olson, Bhaskara Rao Nallaganchu, Cyril H Benes, Joshua E Allen, Varun V Prabhu, Martin Stogniew, Wolfgang Oster, Wafik S El-Deiry
Anti-cancer small molecule ONC201 upregulates the integrated stress response (ISR) and acts as a dual inactivator of Akt/ERK, leading to TRAIL gene activation. ONC201 is under investigation in multiple clinical trials to treat patients with cancer. Given the unique imipridone core chemical structure of ONC201, we synthesized a series of analogues to identify additional compounds with distinct therapeutic properties. Several imipridones with a broad range of in vitro potencies were identified in an exploration of chemical derivatives...
May 10, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28471876/the-inherent-challenges-of-using-large-data-sets-in-healthcare-research-experiences-of-an-interdisciplinary-team
#8
Aaron Kaulfus, Susan Alexander, Shuang Zhao, Robert A Oster, Louise C OʼKeefe, Al Bartolucci
No abstract text is available yet for this article.
May 2017: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/28464705/receipt-and-timing-of-hiv-drug-resistance-testing-in-six-u-s-jurisdictions
#9
Sharoda Dasgupta, H Irene Hall, Angela L Hernandez, M Cheryl Bañez Ocfemia, Neeraja Saduvala, Alexandra M Oster
The Department of Health and Human Services recommends drug resistance testing at linkage to HIV care. Because receipt and timing of testing are not well characterized, we examined testing patterns among persons with diagnosed HIV who are linked to care. Using surveillance data in six jurisdictions for persons aged ≥13 years with HIV infection diagnosed in 2013, we assessed the proportion receiving testing, and among these, the proportion receiving testing at linkage. Multivariable log-binomial regression modeling estimated associations between selected characteristics and receipt of testing (1) overall, and (2) at linkage among those tested...
May 3, 2017: AIDS Care
https://www.readbyqxmd.com/read/28463520/regional-responses-to-the-challenge-of-delivering-integrated-care-to-older-people-with-mental-health-problems-in-rural-australia
#10
Julie Henderson, Suzanne Dawson, Jeffrey Fuller, Deb O'Kane, Adam Gerace, Candice Oster, Eimear Muir Cochrane
OBJECTIVE: Integrated care has been identified as means of managing the demands on the healthcare budget while improving access to and quality of services. It is particularly pertinent to rural health services, which face limited access to specialist and support services. This paper explores the capacity of three rural communities in South Australia to deliver integrated mental health support for older people. METHODS: Thirty-one interviews were conducted with local health and social service providers from mental health, community health, general practice, residential aged care, private practice, NGOs and local government as part of a larger action research project on service integration...
May 2, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28458918/transmission-fitness-of-drug-resistant-hiv-revealed-in-a-surveillance-system-transmission-network
#11
Joel O Wertheim, Alexandra M Oster, Jeffrey A Johnson, William M Switzer, Neeraja Saduvala, Angela L Hernandez, H Irene Hall, Walid Heneine
Test-and-treat programs are central to the global control of HIV, but transmitted drug resistance threatens the effectiveness of these programs. HIV mutations conferring resistance to antiretroviral drugs reduce replicative fitness in vitro, but their effect on propagation in vivo is less understood. Here, we estimate transmission fitness of these mutations in antiretroviral-naïve populations in the U.S. National HIV Surveillance System by comparing their frequency of clustering in a genetic transmission network relative with wild-type viruses...
January 2017: Virus Evolution
https://www.readbyqxmd.com/read/28455551/erratum-to-older-age-at-the-completion-of-linear-growth-is-associated-with-an-increased-risk-of-adult-glioma
#12
Rebecca B Little, L Burt Nabors, Jeffrey J Olson, Zachary J Thompson, Carrie M Rozmeski, Renato V LaRocca, Peter A Forsyth, Reid C Thompson, Robert A Oster, Sajeel A Chowdhary, Kathleen M Egan
No abstract text is available yet for this article.
April 28, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28450120/hiv-acquisition-and-transmission-among-men-who-have-sex-with-men-and-women-what-we-know-and-how-to-prevent-it
#13
Donna Hubbard McCree, Alexandra M Oster, William L Jeffries, Damian J Denson, Ashley C Lima, Hilary Whitman, Wade Ivy, Kirk D Henny
Men who have sex with men and women (MSMW) compose a subset of men who have sex with men (MSM) and represent an estimated 35% of MSM. Research on the HIV risk behaviors of MSMW has largely focused on their behaviors in comparison to men who have sex with men only (MSMO). Results suggest that compared to MSMO, MSMW are less likely to have ever had an HIV test, are at greater risk of being unaware of their HIV infection and are less likely to have encountered HIV prevention activities or materials. Additional research is needed to provide a more comprehensive understanding of the unique sexual behaviors and lived experience of MSMW as a group in order to better inform HIV prevention efforts...
April 24, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28448626/genetic-background-dependent-effects-of-murine-micro-rnas-on-circadian-clock-function
#14
Silke Kiessling, Ahmet Ucar, Kamal Chowdhury, Henrik Oster, Gregor Eichele
MicroRNAs (miRs) are important regulators of a wide range of biological processes. Antagomir studies suggest an implication of miR-132 in the functionality of the mammalian circadian clock. miR-212 and miR-132 are tandemly processed from the same transcript and share the same seed region. We found the clock modulator miR-132 and miR-212 to be expressed rhythmically in the central circadian clock. Consequently, mRNAs implicated in circadian functions may likely be targeted by both miRs. To further characterize the circadian role we generated mice with stable deletion of the miR-132/212 locus and compared the circadian behavior of mutant and wild-type control animals on two genetic backgrounds frequently used in chronobiological research, C57BL/6N and 129/Sv...
2017: PloS One
https://www.readbyqxmd.com/read/28444394/tissue-specific-dissociation-of-diurnal-transcriptome-rhythms-during-sleep-restriction-in-mice
#15
Jana Husse, Jana-Thabea Kiehn, Johanna L Barclay, Nadine Naujokat, Judit Meyer-Kovac, Hendrik Lehnert, Henrik Oster
Study objectives: Shortened or mistimed sleep affects metabolic homeostasis, which may in part be mediated by dysregulation of endogenous circadian clocks. In this study, we assessed the contribution of sleep disruption to metabolic dysregulation by analysing diurnal transcriptome regulation in metabolic tissues of mice subjected to a sleep restriction paradigm. Methods: Male mice were subjected to 2x5 days of sleep restriction (SR) with enforced waking during the first six hours of the light phase...
April 24, 2017: Sleep
https://www.readbyqxmd.com/read/28430109/acquisition-of-electrocardiogram-signals-during-magnetic-resonance-imaging
#16
Julien Oster, Gari Clifford
The recording of the electrocardiogram (ECG) during Magnetic Resonance Imaging (MRI) acquisition is of great interest and importance. Firstly, MRI acquisition is a relatively slow process, which therefore complicates the imaging of moving organs. Cardiac MRI requires the development of strategies for acquiring high quality images, which is mainly achieved by synchronising the image acquisition with a specific time during the cardiac cycle. The ECG is used to monitor the heart's activity, and the detection of the largest and steepest peak in the cardiac cycle (the QRS complex) triggers the acquisition of slices of the k-space...
April 21, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28424227/onc201-demonstrates-anti-tumor-effects-in-both-triple-negative-and-non-triple-negative-breast-cancers-through-trail-dependent-and-trail-independent-mechanisms
#17
Marie D Ralff, Christina L B Kline, Ozan C Küçükkase, Jessica Wagner, Bora Lim, David T Dicker, Varun V Prabhu, Wolfgang Oster, Wafik S El-Deiry
Breast cancer is a major cause of cancer-related death. TRAIL has been of interest as a cancer therapeutic, but only a subset of triple negative breast cancers (TNBC) is sensitive to TRAIL. The small molecule ONC201 induces expression of TRAIL and its receptor DR5. ONC201 has entered clinical trials in advanced cancers. Here we show that ONC201 is efficacious against both TNBC and non-TNBC cells (n=13)--. A subset of TNBC and non-TNBC cells succumb to ONC201-induced cell death. In 2/8 TNBC cell lines, ONC201 treatment induces caspase-8 cleavage and cell death that is blocked by TRAIL-neutralizing antibody RIK2...
April 19, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28417473/ophthalmology-patients-interest-in-online-access-to-clinic-notes-at-three-us-clinics
#18
Bryan S Lee, Natalia V Oster, Galen Y Chen, Leona L Ding, Janice D Walker, Joann G Elmore
PURPOSE: This study aimed to understand patients' perceptions about potential benefits and harms of accessing their own ophthalmology clinic notes via an electronic patient portal as part of the OpenNotes initiative. METHODS: The authors conducted a cross-sectional, in-person survey of ophthalmology patients at three US eye clinics. The paper survey was self-administered or administered with assistance from study staff before or after patients' clinical visits. The authors used descriptive statistics to summarise patient characteristics and patient attitudes about accessing their ophthalmology notes online...
April 17, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28347928/maintenance-of-membrane-organization-in-the-aging-mouse-brain-as-the-determining-factor-for-preventing-receptor-dysfunction-and-for-improving-response-to-anti-alzheimer-treatments
#19
Julie Colin, Mélanie H Thomas, Lynn Gregory-Pauron, Anthony Pinçon, Marie-Claire Lanhers, Catherine Corbier, Thomas Claudepierre, Frances T Yen, Thierry Oster, Catherine Malaplate-Armand
Although a major risk factor for Alzheimer's disease (AD), the "aging" parameter is not systematically considered in preclinical validation of anti-AD drugs. To explore how aging affects neuronal reactivity to anti-AD agents, the ciliary neurotrophic factor (CNTF)-associated pathway was chosen as a model. Comparison of the neuroprotective properties of CNTF in 6- and 18-month old mice revealed that CNTF resistance in the older animals is associated with the exclusion of the CNTF-receptor subunits from rafts and their subsequent dispersion to non-raft cortical membrane domains...
June 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28332146/physiological-substrates-of-executive-functioning-a-systematic-review-of-the-literature
#20
REVIEW
Bailey A Munro, Lisa L Weyandt, Lily E Hall, Danielle R Oster, Bergljot Gyda Gudmundsdottir, Benjamin G Kuhar
Executive function (EF) is a multifaceted construct that has been defined as a set of higher-order cognitive processes that allow for flexibility, self-regulation, strategic planning, and goal-directed behaviors. EFs have been studied in numerous clinical disorders using a variety of neuropsychological tasks and, more recently, neuroimaging techniques. The underlying physiological substrates of EF were historically attributed to the frontal lobes; however, recent studies suggest more widespread involvement of additional brain regions...
March 22, 2017: Attention Deficit and Hyperactivity Disorders
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