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https://www.readbyqxmd.com/read/27912209/databases-for-congenital-heart-defect-public-health-studies-across-the-lifespan
#1
REVIEW
Tiffany J Riehle-Colarusso, Lisa Bergersen, Craig S Broberg, Cynthia H Cassell, Darryl T Gray, Scott D Grosse, Jeffrey P Jacobs, Marshall L Jacobs, Russell S Kirby, Lazaros Kochilas, Asha Krishnaswamy, Arianne Marelli, Sara K Pasquali, Thalia Wood, Matthew E Oster
No abstract text is available yet for this article.
October 26, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27894567/proportion-of-selected-congenital-heart-defects-attributable-to-recognized-risk-factors
#2
Regina M Simeone, Sarah C Tinker, Suzanne M Gilboa, A J Agopian, Matthew E Oster, Owen J Devine, Margaret A Honein
PURPOSE: To assess the contribution of multiple risk factors for two congenital heart defects-hypoplastic left heart syndrome (HLHS) and tetralogy of Fallot (TOF). METHODS: We used data from the National Birth Defects Prevention Study (1997-2011) to estimate average adjusted population attributable fractions for several recognized risk factors, including maternal prepregnancy overweight-obesity, pregestational diabetes, age, and infant sex. RESULTS: There were 594 cases of isolated simple HLHS, 971 cases of isolated simple TOF, and 11,829 controls in the analysis...
December 2016: Annals of Epidemiology
https://www.readbyqxmd.com/read/27874252/pediatric-cardiac-readmissions-an-opportunity-for-quality-improvement
#3
Jeffrey H Sacks, Michael Kelleman, Courtney McCracken, Michelle Glanville, Matthew Oster
OBJECTIVE: Hospital readmissions are increasingly becoming a metric for quality in the current landscape of changing and cost effective medicine. However, no 30-d readmission rates have been established for pediatric cardiac medical patients in the United States. Thus, the objective was to determine 30 d readmission rates and risk factors associated with readmission for pediatric cardiac patients, hypothesizing that pediatric cardiac patients would have significantly higher readmission rates than their general pediatric counterparts...
November 22, 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/27870945/erythropoietin-administration-is-associated-with-improved-t-cell-properties-in-patients-with-myelodysplastic-syndromes
#4
Naamit Deshet-Unger, Howard S Oster, Sara Prutchi-Sagiv, Nir Maaravi, Nataliya Golishevski, Drorit Neumann, Moshe Mittelman
The immune system is impaired in myelodysplastic syndromes (MDS) and plays a role in the pathogenesis of the disease. Here we show effects of recombinant human erythropoietin (rHuEPO) on T cell (CD4(+), CD8(+) and CD4(+)CD25(+)) number and function in MDS patients. Healthy (20 subjects), MDS patients without rHuEPO treatment ('MDS', 13), and MDS patients treated with rHuEPO ('MDS+EPO', 17) were examined. CD4(+) and CD8(+) T cell numbers were reduced and increased respectively in MDS compared to healthy subjects...
November 2, 2016: Leukemia Research
https://www.readbyqxmd.com/read/27855999/assessment-of-growth-6-years-after-the-norwood-procedure
#5
Phillip T Burch, Chitra Ravishankar, Jane W Newburger, Linda M Lambert, Victoria L Pemberton, Suzanne Granger, Alejandro A Floh, Jeffrey B Anderson, Garick D Hill, Kevin D Hill, Matthew E Oster, Alan B Lewis, Kurt R Schumacher, Sinai C Zyblewski, Ryan R Davies, Jeffrey P Jacobs, Wyman W Lai, L LuAnn Minich
: At 6 years of age, patients with hypoplastic left heart syndrome had mean age-adjusted z-scores for weight and height below the normative population, and body mass index was similar to the normative population. Males had the greatest increase in z-scores for body mass index. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00115934.
November 14, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27831696/neuropsychological-functioning-in-college-students-with-and-without-adhd
#6
Lisa L Weyandt, Danielle R Oster, Bergljot Gyda Gudmundsdottir, George J DuPaul, Arthur D Anastopoulos
Objective: Increasing numbers of students with attention-deficit/hyperactivity disorder (ADHD) are attending college; however, little empirical information is available concerning the functional impairment experienced by these students. Although preliminary studies suggest that college students with ADHD are more likely to experience a variety of psychosocial and academic difficulties compared to their peers without the disorder, findings regarding neuropsychological functioning have been inconsistent with some studies reporting that college students with ADHD perform more poorly on various cognitive and neuropsychological tasks while others report no differences compared to their peers without ADHD...
November 10, 2016: Neuropsychology
https://www.readbyqxmd.com/read/27789735/expression-profile-of-hepatic-genes-related-to-lipid-homeostasis-in-lsr-heterozygous-mice-contribute-to-their-increased-response-to-high-fat-diet
#7
Samina Akbar, Anthony Pincon, Marie-Claire Lanhers, Thomas Claudepierre, Catherine Corbier, Lynn Gregory-Pauron, Catherine Malaplate-Armand, Athanase Visvikis, Thierry Oster, Frances T Yen
Perturbations of lipid homeostasis manifest as dyslipidemias and obesity, which are significant risk factors for atherosclerosis and diabetes. Lipoprotein receptors in the liver are key players in the regulation of lipid homeostasis, among which the hepatic lipolysis stimulated lipoprotein receptor, LSR, was recently shown to play an important role in the removal of lipoproteins from the circulation during the postprandial phase. Since heterozygous LSR+/- mice demonstrate moderate dyslipidemia and develop higher body weight gain in response to high-fat diet as compared to littermate LSR+/+ controls, we questioned if LSR heterozygosity could affect genes related to hepatic lipid metabolism...
October 27, 2016: Physiological Genomics
https://www.readbyqxmd.com/read/27777443/best-practices-for-biostatistical-consultation-and-collaboration-in-academic-health-centers
#8
Susan M Perkins, Peter Bacchetti, Cynthia S Davey, Christopher J Lindsell, Madhu Mazumdar, Robert A Oster, Peter N Peduzzi, David M Rocke, Kyle D Rudser, Mimi Kim
Given the increasing level and scope of biostatistics expertise needed at academic health centers today, we developed best practices guidelines for biostatistics units to be more effective in providing biostatistical support to their institutions, and in fostering an environment in which unit members can thrive professionally. Our recommendations focus on the key areas of: 1) funding sources and mechanisms; 2) providing and prioritizing access to biostatistical resources; and 3) interacting with investigators...
2016: American Statistician
https://www.readbyqxmd.com/read/27760345/theory-from-the-oster-laboratory-leaps-ahead-of-experiment-in-understanding-actin-based-cellular-motility
#9
Thomas D Pollard
No abstract text is available yet for this article.
October 18, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27749086/the-functional-and-clinical-significance-of-the-24-h-rhythm-of-circulating-glucocorticoids
#10
Henrik Oster, Etienne Challet, Volker Ott, Emanuela Arvat, E Ronald de Kloet, Derk-Jan Dijk, Stafford Lightman, Alexandros Vgontzas, Eve Van Cauter
Adrenal glucocorticoids are major modulators of multiple functions, including energy metabolism, stress responses, immunity, and cognition. The endogenous secretion of glucocorticoids is normally characterized by a prominent and robust circadian (around 24 hours) oscillation, with a daily peak around the time of the habitual sleep-wake transition and minimal levels in the evening and early part of the night. It has been long recognized that this 24-h rhythm partly reflects the activity of a master circadian pacemaker located in the suprachiasmatic nucleus of the hypothalamus...
October 17, 2016: Endocrine Reviews
https://www.readbyqxmd.com/read/27717013/increased-troponin-i-is-associated-with-fatal-outcome-in-acquired-thrombotic-thrombocytopenic-purpura
#11
Jason Brazelton, Robert A Oster, Brandi McCleskey, Jessica Fuller, Jill Adamski, Marisa B Marques
Thrombotic thrombocytopenic purpura (TTP) has >90% mortality without therapeutic plasma exchange (TPE). Despite TPE, approximately 10% of patients still die, presumably from cardiac ischemia. We sought clinical or laboratory parameters associated with death by reviewing the records of all patients hospitalized with acquired TTP in our institution for 10 years, and collect demographics and results for hemoglobin, platelet count, creatinine, lactate dehydrogenase, transaminases, total bilirubin, creatinine kinase (CK), CK-MB, and troponin I...
September 26, 2016: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/27690710/achieve-control-a-pragmatic-clinical-trial-of-insulin-glargine-300-u-ml-versus-other-basal-insulins-in-insulin-na%C3%A3-ve-patients-with-type-2-diabetes
#12
Gerry Oster, Sean D Sullivan, Mehul R Dalal, Mahmood R Kazemi, Maria Rojeski, Carol H Wysham, Jennifer Sung, Bryan Johnstone, Anna M G Cali, L J Wei, Louise Traylor, Henry Anhalt, Michelle Hull, John Van Vleet, Luigi F Meneghini
OBJECTIVE: This study aims to compare the effectiveness of insulin glargine 300 U/mL (Gla-300) with its accompanying patient support program with that of other basal insulin and available patient support programs in patients with type 2 diabetes (T2D) in a real-world setting in terms of achieving HEDIS (Healthcare Effectiveness Data and Information Set) individualized glycemic targets without documented symptomatic hypoglycemia. STUDY DESIGN AND METHODS: Achieve Control is a US-based, multicenter, randomized, open-label, active-controlled, parallel group pragmatic Phase IV trial in insulin-naïve patients with T2D uncontrolled on ≥2 oral antidiabetes drugs (OAD) and/or glucagon-like peptide-1 receptor antagonists (GLP-1 RA)...
October 3, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27690690/dissociation-of-molecular-and-endocrine-circadian-rhythms-in-male-mice-lacking-bmal1-in-the-adrenal-cortex
#13
Rebecca Dumbell, Alexei Leliavski, Olga Matveeva, Christopher Blaum, Anthony H Tsang, Henrik Oster
The circadian rhythm of glucocorticoids affects diverse physiological systems, including stress responses and the coordination of rhythmic functions in peripheral and central tissues. Circadian clocks are considered to be important coordinators of glucocorticoid release and loss of the core clock component BMAL1 leads to ablation of behavioural and physiological rhythms, hypocortisolism, impaired ACTH and behavioural stress responses. Transplantation and conditional clock gene knock-down studies in mice suggest an important role of local adrenocortical clock function in this context...
October 3, 2016: Endocrinology
https://www.readbyqxmd.com/read/27690507/prescription-stimulant-medication-misuse-where-are-we-and-where-do-we-go-from-here
#14
Lisa L Weyandt, Danielle R Oster, Marisa E Marraccini, Bergljot Gyda Gudmundsdottir, Bailey A Munro, Emma S Rathkey, Alison McCallum
Prescription stimulants, including methylphenidate (e.g., Ritalin) and amphetamine compounds (e.g., dextroamphetamine; Adderall), have been approved by the U.S. Food and Drug Administration for the treatment of attention-deficit/hyperactivity disorder (ADHD) and are classified by the United States Drug Enforcement Administration as Schedule II medications because of their high potential for abuse and dependence (Drug Enforcement Administration, U.S. Department of Justice, 2015). Despite the potential health and judicial consequences, misuse of prescription stimulants, typically defined as taking stimulants without a valid prescription, or use of stimulants other than as prescribed, has become a serious problem in the United States and abroad, especially on college campuses...
October 2016: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27660201/time-of-day-dependent-adaptation-of-the-hpa-axis-to-predictable-social-defeat-stress
#15
Christiane Koch, Manuela S Bartlang, Jana Thabea Kiehn, Lisa Lucke, Nadine Naujokat, Charlotte Helfrich-Förster, Stefan O Reber, Henrik Oster
In modern societies, the risk of developing a whole array of affective and somatic disorders is associated with the prevalence of frequent psychosocial stress. Therefore, a better understanding of adaptive stress responses and their underlying molecular mechanisms is of high clinical interest. In response to an acute stressor each organism can either show passive freezing or active fight-or-flight behavior, with activation of sympathetic nervous system and the hypothalamus-pituitary-adrenal (HPA) axis providing the necessary energy for the latter by releasing catecholamines and glucocorticoids (GC)...
September 22, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27650461/the-scn-clock-governs-circadian-transcription-rhythms-in-murine-epididymal-white-adipose-tissue
#16
Isa Kolbe, Jana Husse, Gabriela Salinas, Thomas Lingner, Mariana Astiz, Henrik Oster
The circadian master pacemaker in the suprachiasmatic nucleus (SCN) orchestrates peripheral clocks in various organs and synchronizes them with external time, including those in adipose tissue, which displays circadian oscillations in various metabolic and endocrine outputs. Because our knowledge about the instructive role of the SCN clock on peripheral tissue function is based mainly on SCN lesion studies, we here used an alternative strategy employing the Cre/loxP system to functionally delete the SCN clock in mice...
September 20, 2016: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/27633639/exploring-effects-of-presurgical-weight-loss-among-women-with-stage-0-ii-breast-cancer-protocol-for-a-randomised-controlled-feasibility-trial
#17
Yuko Tsuruta, Laura Q Rogers, Helen Krontiras, William E Grizzle, Andrew D Frugé, Robert A Oster, Heidi R Umphrey, Lee W Jones, Maria Azrad, Wendy Demark-Wahnefried
INTRODUCTION: Obesity is a known risk factor for postmenopausal breast cancer and is associated with poorer prognosis for premenopausal and postmenopausal patients; however, the aetiological mechanisms are unknown. Preclinical studies support weight loss via caloric restriction and increased physical activity as a possible cancer control strategy, though few clinical studies have been conducted. We undertook a feasibility trial among women recently diagnosed with stage 0-II breast cancer hypothesising that presurgical weight loss would be feasible, safe and result in favourable changes in tumour markers and circulating biomarkers...
September 15, 2016: BMJ Open
https://www.readbyqxmd.com/read/27612323/microleakage-around-class-v-composite-restorations-after-ultrasonic-scaling-and-sonic-toothbrushing-around-their-margin
#18
Ronald E Goldstein, Suruchi Lamba, Nathaniel C Lawson, Preston Beck, Robert A Oster, John O Burgess
OBJECTIVES: To measure microleakage around class V composite restorations after piezoelectric ultrasonic scaling and sonic toothbrushing. METHODS: 3 mm × 2 mm × 1.5 mm boxes were prepared on buccal and lingual surfaces of extracted molars centered on the cementum-enamel junction. Half the preparations were beveled (0.5 mm). Preparations were restored with composite and polished. Restorations on one side of the teeth were either traced with an ultrasonic scaler (60 seconds, n = 16) or brushed in a sonic toothbrushing machine (2 hours, n = 16)...
September 9, 2016: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/27602582/discovery-and-clinical-introduction-of-first-in-class-imipridone-onc201
#19
Joshua E Allen, C Leah B Kline, Varun V Prabhu, Jessica Wagner, Jo Ishizawa, Neel Madhukar, Avital Lev, Marie Baumeister, Lanlan Zhou, Amriti Lulla, Martin Stogniew, Lee Schalop, Cyril Benes, Howard L Kaufman, Richard S Pottorf, B Rao Nallaganchu, Gary L Olson, Fahd Al-Mulla, Madeleine Duvic, Gen Sheng Wu, David T Dicker, Mala K Talekar, Bora Lim, Olivier Elemento, Wolfgang Oster, Joseph Bertino, Keith Flaherty, Michael L Wang, Gautam Borthakur, Michael Andreeff, Mark Stein, Wafik S El-Deiry
ONC201 is the founding member of a novel class of anti-cancer compounds called imipridones that is currently in Phase II clinical trials in multiple advanced cancers. Since the discovery of ONC201 as a p53-independent inducer of TRAIL gene transcription, preclinical studies have determined that ONC201 has anti-proliferative and pro-apoptotic effects against a broad range of tumor cells but not normal cells. The mechanism of action of ONC201 involves engagement of PERK-independent activation of the integrated stress response, leading to tumor upregulation of DR5 and dual Akt/ERK inactivation, and consequent Foxo3a activation leading to upregulation of the death ligand TRAIL...
September 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27594339/membrane-raft-domains-and-remodeling-in-aging-brain
#20
Julie Colin, Lynn Gregory-Pauron, Marie-Claire Lanhers, Thomas Claudepierre, Catherine Corbier, Frances T Yen, Catherine Malaplate-Armand, Thierry Oster
Lipids are the fundamental structural components of biological membranes. For a long time considered as simple barriers segregating aqueous compartments, membranes are now considered as dynamic interfaces providing a molecular environment favorable to the activity of membrane-associated proteins. Interestingly, variations in membrane lipid composition, whether quantitative or qualitative, play a crucial role in regulation of membrane protein functionalities. Indeed, a variety of alterations in brain lipid composition have been associated with the processes of normal and pathological aging...
September 1, 2016: Biochimie
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