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Emilie M Flament, Keith R Berend, Jason M Hurst, Michael J Morris, Joanne B Adams, Adolph V Lombardi
BACKGROUND: In past decades, polyethylene wear was a major cause of failure in total knee arthroplasty (TKA). Polyethylene for use in arthroplasty has been vastly improved in recent years, with improved materials as well as manufacturing and sterilization processes. Testing has shown that infusion of vitamin E prevents oxidative degradation of polyethylene without remelting, allowing the material to maintain mechanical properties and wear resistance over time. The purpose of this study is to review the early result of patients undergoing primary TKA with vitamin E antioxidant-infused polyethylene inserts...
October 26, 2016: Surgical Technology International
Ashlee J Howarth, Cassandra T Buru, Yangyang Liu, Ann M Ploskonka, Karel J Hartlieb, Monica McEntee, John J Mahle, James H Buchanan, Erin M Durke, Salih S Al-Juaid, J Fraser Stoddart, Jared B Decoste, Joseph T Hupp, Omar K Farha
A fullerene-based photosensitizer is incorporated postsynthetically into a Zr6-based MOF, NU-1000, for enhanced singlet oxygen production. The structural organic linkers in the MOF platform also act as photosensitizers which contribute to the overall generation of singlet oxygen from the material under UV irradiation. The singlet oxygen generated by the MOF/fullerene material is shown to oxidize sulfur mustard selectively to the less toxic bis(2-chloroethyl)sulfoxide with a half-life of only 11 min.
October 25, 2016: Chemistry: a European Journal
I A Välimäki, T Vuorimaa, M Ahotupa, T Vasankari
We studied the effects of different types of exercises on the concentrations of oxidised HDL (oxHDLlipids) and LDL lipids (oxLDLlipids), serum lipids, antioxidant potential, paraoxonase and malondialdehyde in endurance runners by performing both a 40-min continuous run (velocity corresponding to 80% VO2max) and a 40-min intermittent run (2-min run, velocity corresponding to 100% VO2max, and 2-min rest) using a treadmill. Blood samples were taken before exercise, after 20 and 40 min of exercise, and 15 and 90 min after the end of exercise...
October 25, 2016: International Journal of Sports Medicine
Xiang Li, Handong Wang, Yongyue Gao, Liwen Li, Chao Tang, Guodao Wen, Yuan Zhou, Mengliang Zhou, Lei Mao, Youwu Fan
The present investigation was carried out to elucidate a possible molecular mechanism related to the protective effect of quercetin administration against oxidative stress on various mitochondrial respiratory complex subunits with special emphasis on the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in mitochondrial biogenesis. Recently, quercetin has been proved to have a protective effect against mitochondria damage after traumatic brain injury (TBI). However, its precise role and underlying mechanisms in traumatic brain injury are not yet fully understood...
2016: PloS One
Aviram Kogot-Levin, Ann Saada, Gil Leibowitz, Devorah Soiferman, Liza Douiev, Itamar Raz, Sarah Weksler-Zangen
Cytochrome-c-oxidase (COX) deficiency is a frequent cause of mitochondrial disease and is associated with a wide spectrum of clinical phenotypes. We studied mitochondrial function and biogenesis in fibroblasts derived from the Cohen (CDs) rat, an animal model of COX deficiency. COX activity in CDs-fibroblasts was 50% reduced compared to control rat fibroblasts (P<0.01). ROS-production in CDs fibroblasts increased, along with marked mitochondrial fragmentation and decreased mitochondrial membrane-potential, indicating mitochondrial dysfunction...
2016: PloS One
Darshana Kadekar, Sonal Rangole, Vaijayanti Kale, Lalita Limaye
BACKGROUND: The limited cell dose in umbilical cord blood (UCB) necessitates ex vivo expansion of UCB. Further, the effective cryopreservation of these expanded cells is important in widening their use in the clinics. During cryopreservation, cells experience oxidative stress due to the generation of reactive oxygen species (ROS). Conditioned medium from mesenchymal stem cells (MSCs-CM) has been shown to alleviate the oxidative stress during wound healing, Alzheimer's disease and ischemic disease...
2016: PloS One
Kuan-Ho Lin, Chien-Liang Liu, Wei-Wen Kuo, Catherine Reena Paul, Wei-Kung Chen, Su-Ying Wen, Cecilia Hsuan Day, Hsi-Chin Wu, Vijaya Padma Viswanadha, Chih-Yang Huang
Cardiac trauma has been recognized as a complication associated with blunt chest trauma involving coronary artery injury, myocardium contusion and myocardial rupture. Secondary cardiac injuries after trauma supposed to be a critical factor in trauma patients, but the mechanism is not fully explored. Overproduction of TNF-alpha had been reported in multiple trauma animals, this induces oxidative stress resulting in cardiac apoptosis. Apoptosis gradually increases after trauma and reaches to a maximum level in 12 h time...
2016: PloS One
Fatemeh Shaki, Sorour Ashari, Nematollah Ahangar
BACKGROUND: Ciprofloxacin is a synthetic broad-spectrum antimicrobial agent of fluoroquinolone family. The aim of our investigation was to evaluate the role of oxidative damage and inflammation in nephrotoxic potential of Ciprofloxacin and protective effects of melatonin against its nephrotoxicity in male Wistar rats. METHODS: The animals were divided into six groups: Control, ciprofloxacin (100mg/kg/day, i.p), ciprofloxacin with three doses (2.5, 5 and 10mg/kg/day) of melatonin and a group which received ciprofloxacin (100mg/kg/day) plus vitamin E (100mg/kg/day) for 8 consecutive days...
October 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Meijun Song, Hongcheng Wu, Shibo Wu, Ting Ge, Guoan Wang, Yingyan Zhou, Shimo Sheng, Jingbo Jiang
Lung cancer is the leading cause of cancer death worldwide and its clinical management remains challenge. Here, we repurposed antibiotic levofloxacin for lung cancer treatment. We show that levofloxacin is effectively against a panel of lung cancer cell lines via inhibiting proliferation and inducing apoptosis, regardless of cellular origin and genetic pattern, in in vitro cell culture system and in vivo xenograft lung tumor model. Mechanistically, levofloxacin inhibits activities of mitochondrial electron transport chain complex I and III, leading to inhibition of mitochondrial respiration and reduction of ATP production...
October 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yamou Wu, Chengyong Gu, Xiaochen Huang
This present study was aimed to investigate the molecular mechanisms involved in sevoflurane protection of hepatic ischemia-reperfusion (I/R) injury. Firstly, we investigated the protective effects of sevoflurane against hepatic I/R injury. Biochemical analysis results showed that sevoflurane preconditioning significantly protected against hepatic I/R injury by reducing liver enzymes and improving antioxidant defense markers. We also found that sevoflurane attenuates I/R-induced hepatic cell death, by TUNEL staining, DNA fragmentation ELISA and PARP activity determination...
October 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Anouar Ben Saad, Ilhem Rjeibi, Dalel Brahmi, Amani Smida, Sana Ncib, Nacim Zouari, Lazher Zourgui
Malva sylvestris has recently attracted special attention due to its potential activities in many chronic disorders. We aimed to assess the beneficial effects of Malva sylvestris extract against lithium carbonate induced renal damage in male Wistar rats. For this purpose, Malva sylvestris extract at a dose of 0.2g/kg was orally administrated, followed by 25mg/kg of lithium carbonate (intraperitoneal injection) for 30 days. Malva sylvestris extract was proved to contain large amounts of K(+), Na(+), Ca(++) and the existence of phenolic acids and flavonoids shown by the obtained HPLC-based analysis...
October 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Bakhta Aouey, Amira Mahjoubi Samet, Hamadi Fetoui, Monique S J Simmonds, Mohamed Bouaziz
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Vitis vinifera is used in traditional medicine for diarrhea, hepatitis and stomachaches. The objective of this study was to investigate the anti-oxidant, anti-inflammatory, analgesic and antipyretic properties of the hydroalcoholic leaf extract of Vitis vinifera (EVV) on experimental models to provide scientific basis for its use. MATERIALS AND METHODS: The EVV was chemically characterized by LC-MS/MS analyses. The in vitro antioxidant activities of the EVV extract were measured using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay and Ferric reducing antioxidant power assay (FRAP)...
October 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Xin Yu Leong, Punniyakoti Veeraveedu Thanikachalam, Manisha Pandey, Srinivasan Ramamurthy
BACKGROUND: Swertiamarin, is a secoiridoid glycoside found in genera of Enicostemma Species (Enicostemma littorale and Enicostemma axillare) belonging to the family of gentianaceae, which has been reported to cure many diseases such as diabetes, hypertension, atherosclerosis, arthritis, malaria and abdominal ulcers. However, to the best of our knowledge, till date systematic studies to understand the molecular basis of cardiac and metabolic disease preventing properties of swertiamarin has not been reported...
October 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Elixabet Díaz-de-Cerio, Federica Pasini, Vito Verardo, Alberto Fernández-Gutiérrez, Antonio Segura-Carretero, Maria Fiorenza Caboni
Due to the importance of the proanthocyanidins (PAs) bioactivity and its relationship with the PAs degree of polymerization (DP), an experimental design was carried out to establish the best extraction conditions in order to evaluate the proanthocyanidins content and their degree of polymerization in Psidium guajava leaves at different oxidation state. Optimal conditions achieved by response surface methodology were 50% acetone/water (v/v), 48°C, 30min, and 0% acetic acid (v/v). The highest DP has been found in the low oxidized state (DP 13 plus the polymers)...
October 13, 2016: Journal of Pharmaceutical and Biomedical Analysis
Tânia F C V Silva, Petrick A Soares, Diego R Manenti, Amélia Fonseca, Isabel Saraiva, Rui A R Boaventura, Vítor J P Vilar
In this work, an innovative methodology for the treatment of landfill leachates, after aerobic lagooning, is proposed and adjusted at pilot-scale. This methodology involves an aerobic activated sludge biological pre-oxidation (ASBO), a coagulation/sedimentation step (240mgFe(3+)/L, at pH4.2) and a photo-oxidation through a photo-Fenton (PF) reaction (60mg Fe(2+), at pH2.8) combining solar and artificial light. The ASBO process applied to a leachate after aerobic lagooning, with high organic and nitrogen content (1...
October 22, 2016: Science of the Total Environment
Sangil Kwon, Yonghee Park, Junhong Park, Jeongsoo Kim, Kwang-Ho Choi, Jun-Seok Cha
This paper presents the on-road nitrogen oxides (NOx) emissions measurements from Euro 6 light-duty diesel vehicles using a portable emissions measurement system on the predesigned test routes in the metropolitan area of Seoul, Korea. Six diesel vehicles were tested and the NOx emissions results were analyzed according to the driving routes, driving conditions, data analysis methods, and ambient temperatures. Total NOx emissions for route 1, which has higher driving severity than route 2, differed by -4-60% from those for route 2...
October 22, 2016: Science of the Total Environment
V L Shirokova, A M L Enright, C B Kennedy, F G Ferris
This investigation evaluates spatial relationships between summer (July) groundwater temperatures and Fe(II)/Fe(III) biogeochemical cycling over a five year period in a shallow pristine sand aquifer at Meilleurs Bay near Deep River, Ontario, Canada. A warm subsurface thermal island of 12.5-16.1 °C, compared to background conditions of 10-11 °C, was manifest in contour maps of average groundwater temperature over the study period. The warm zone coincided with an area of convergent groundwater flow, implicating horizontal heat transfer by advective convection as the reason for elevated temperatures...
October 19, 2016: Water Research
Ramaz Khomeriki, Levan Chotorlishvili, Igor Tralle, Jamal Berakdar
We uncover and identify the regime for a magnetically and ferroelectrically controllable negative refraction of light traversing multiferroic, oxide-based metastructure consisting of alternating nanoscopic ferroelectric (SrTiO2) and ferromagnetic (Y3Fe2(FeO4)3, YIG) layers. We perform analytical and numerical simulations based on discretized, coupled equations for the self-consistent Maxwell/ferroelectric/ferromagnetic dynamics and obtain a biquadratic relation for the refractive index. Various scenarios of ordinary and negative refraction in different frequency ranges are analyzed and quantified by simple analytical formula that are confirmed by full-fledge numerical simulations...
October 25, 2016: Nano Letters
Anaïs Bouisseau, John Glancy, Michael C Willis
β'-Thio-substituted-enones, assembled from the combination of β-tert-butylthio-substituted aldehydes and alkynes, using rhodium catalysis, are shown to smoothly undergo in situ intramolecular S-conjugate addition to deliver a range of S-heterocycles in a one-pot process. Aryl, alkenyl, and alkyl aldehydes can all be employed, to provide thiochroman-4-ones, hexahydro-4H-thiochromen-4-ones, and tetrahydrothiopyran-4-ones, respectively. A variety of in situ oxidations are also performed, allowing access to S,S-dioxide derivatives, as well as unsaturated variants...
October 25, 2016: Organic Letters
Qiangmin Yu, Chuxin Wu, Lunhui Guan
We report an efficient method for enriching high-purity metallic single-walled carbon nanotubes (m-SWCNTs) by using NO2 as oxidant to remove semiconducting components at 220°C. After etching, the m-SWCNTs with purity higher than 90% were obtained. The surviving m-SWCNTs remain intact structure, without any extra defects on their surface.
October 25, 2016: Journal of Physical Chemistry Letters
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