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Pneumonia in elderly

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https://www.readbyqxmd.com/read/29138974/medical-complications-and-mortality-in-octogenarians-undergoing-elective-spinal-fusion-surgeries
#1
Sharad Rajpal, E Lee Nelson, Alan T Villavicencio, Jayratna Telang, Roshan Kantha, Kara Beasley, Sigita Burneikiene
BACKGROUND: The consequences of suffering postoperative complications in elderly undergoing spinal surgeries may be different compared to younger patients. The primary objective of this study was to identify the types and frequency of medical complications and mortality rates in patients 80 years of age or older undergoing elective spinal fusion surgeries for degenerative spinal disease. METHODS: A prospective observational study with a retrospective chart review was performed, which included all consecutive patients ≥80 years old undergoing elective spinal fusion surgeries from May 2012 to August 2015...
November 14, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29135343/effects-of-influenza-immunization-on-pneumonia-in-the-elderly
#2
Jung Yeon Heo, Joon Young Song, Ji Yun Noh, Min Joo Choi, Jin Gu Yoon, Saem Na Lee, Hee Jin Cheong, Woo Joo Kim
Influenza virus is a common pathogen implicated in respiratory tract infections, annually affecting up to 20% of the general population, and pneumonia is a leading cause of death after influenza infection. Post-influenza pneumonia is especially common in the elderly and chronically ill patients. The risk of post-influenza pneumonia is significantly increased according to the number of concurrent comorbidities. Vaccination is the primary measure used to abate influenza epidemics and associated complications...
November 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29131496/suboptimal-initiation-predicts-short-term-prognosis-and-vulnerability-among-very-elderly-patients-who-start-hemodialysis
#3
Atsuhiro Kanno, Masaaki Nakayama, Satoru Sanada, Mitsuhiro Sato, Toshinobu Sato, Yoshio Taguma
AIM: A recent, growing concern regarding hemodialysis in Japan is a sustained increase in the elderly population. Among very elderly people who start hemodialysis, the prognosis is considered to be poor; however, this has not been fully elucidated. This study aimed to discover the short-term prognosis and related factors in very elderly patients who commence hemodialysis. METHODS: Between January 2008 and December 2013, 122 patients aged ≥85 years at hemodialysis initiation were documented in our hospital...
November 13, 2017: Nephrology
https://www.readbyqxmd.com/read/29128779/noninvasive-ventilation-failure-in-pneumonia-patients-%C3%A2-65years-old-the-role-of-cough-strength
#4
Yueling Hong, Jun Duan, Linfu Bai, Xiaoli Han, Shicong Huang, Shuliang Guo
PURPOSE: To explore the association between cough strength and outcomes in elderly patients who received noninvasive ventilation (NIV) due to acute respiratory failure caused by pneumonia. MATERIALS AND METHODS: We enrolled patients ≥65years old with acute respiratory failure caused by pneumonia. Just before NIV treatment, cough strength was assessed on a cough-strength scale graded from 0 to 5. Patients graded 0-2 were defined as having no/weak coughs and those graded 3-5 were defined as having moderate/strong coughs...
November 4, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29122806/diagnostic-utility-of-appetite-loss-in-addition-to-existing-prediction-models-for-community-acquired-pneumonia-in-the-elderly-a-prospective-diagnostic-study-in-acute-care-hospitals-in-japan
#5
Toshihiko Takada, Yosuke Yamamoto, Kazuhiko Terada, Mitsuyasu Ohta, Wakako Mikami, Hajime Yokota, Michio Hayashi, Jun Miyashita, Teruhisa Azuma, Shingo Fukuma, Shunichi Fukuhara
OBJECTIVE: Diagnosis of community-acquired pneumonia (CAP) in the elderly is often delayed because of atypical presentation and non-specific symptoms, such as appetite loss, falls and disturbance in consciousness. The aim of this study was to investigate the external validity of existing prediction models and the added value of the non-specific symptoms for the diagnosis of CAP in elderly patients. DESIGN: Prospective cohort study. SETTING: General medicine departments of three teaching hospitals in Japan...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29120096/the-association-between-oral-health-status-and-respiratory-pathogen-colonization-with-pneumonia-risk-in-institutionalized-adults
#6
Chl Hong, M M Aung, K Kanagasabai, C A Lim, S Liang, K S Tan
OBJECTIVES: This study aimed to assess the oral health and the prevalence of pre-existing oral colonization with respiratory pathogens in dependent elderly, and whether these factors influence pneumonia development. MATERIALS AND METHODS: Participants residing in a long-term care facility received bedside oral examinations, and information on their oral health (caries status, calculus index and debris index) was obtained. Samples from the tongue and teeth were collected at baseline and at time of pneumonia development...
November 9, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/29119031/pediatric-pulmonary-epstein-barr-virus-positive-diffuse-large-b-cell-lymphoma-a-case-report-and-review-of-the-literature
#7
Eric X Wei, Roberto F Silva, James D Cotelingam, Rodney E Shackelford
Non-Hodgkin's lymphoma (NHL) is a common malignancy of childhood; however, a lung primary presentation is an uncommon finding, as is finding an association with the Epstein-Barr virus (EBV). We report the case of a 23-month-old female who developed EBV-associated diffuse large B-cell lymphoma (DLBCL) that was initially thought to be pneumonia. Extensive tissue necrosis, focal angioinvasion, and angiodestruction were observed. She was refractory to various therapy regimens, subsequently developed DLBCL in the central nervous system, and eventually expired...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/29118170/lyta-quantitative-pcr-on-sputum-and-nasopharyngeal-swab-samples-in-the-detection-of-pneumococcal-pneumonia-among-the-elderly
#8
Annika Saukkoriipi, Arto A Palmu, Thierry Pascal, Vincent Verlant, William P Hausdorff, Jukka Jokinen
Quantitative real-time PCR (qPCR) on sputum or nasopharyngeal specimens has shown promising results in the detection of pneumococcal community-acquired pneumonia (PncCAP). We applied qPCR for the autolysin gene (lytA) and compared sputum and nasopharyngeal swab (NPS) pneumococcal loads in elderly patients with community-acquired pneumonia (CAP), and specifically in patients with PncCAP, to those in patient groups with other respiratory disease. We studied patients aged ≥65 years with radiologically confirmed CAP, clinical CAP not retrospectively radiologically confirmed, other acute respiratory infection, or stable chronic lung disease...
November 8, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29115367/bahng-score-predictive-model-for-detection-of-subjects-with-the-oropharynx-colonized-by-uncommon-microorganisms
#9
J González-Del Castillo, J Teja-Marina, F J Candel, J Barberán, A Moreno-Cuervo, F Chiarella, L López-González, P Ramos-Cordero, F J Martín-Sánchez
OBJECTIVE: Pneumonia is most frequently produced by the microaspiration of flora that colonizes the oropharynx. Etiological diagnosis of pneumonia is infrequent in clinical practise and empirical treatment should be prescribed. The aims of the present study were to determine the factors associated with oropharynx colonization by uncommon microorganisms (UM) and to develop a predictive model. METHODS: A cross-sectional study that included all pa-tients living in one long-term care facilities was developed...
November 6, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29095281/disease-burden-of-hospitalized-community-acquired-pneumonia-in-south-korea-analysis-based-on-age-and-underlying-medical-conditions
#10
Min Joo Choi, Joon Young Song, Ji Yun Noh, Jin Gu Yoon, Saem Na Lee, Jung Yeon Heo, Jae Won Yoon, Yu Mi Jo, Hee Jin Cheong, Woo Joo Kim
Pneumonia is a leading cause of hospitalization and mortality worldwide. Despite recognition of the importance of community-acquired pneumonia (CAP) in adults, limited epidemiologic information is available in South Korea. This study aimed to evaluate the disease burden of hospitalized CAP in adults aged ≥19 years and its epidemiologic trend using Health Insurance and Review Assessment (HIRA) data.This is a retrospective study using the HIRA database from year 2009 to 2013. We estimated the incidence rate and direct medical cost of hospitalized CAP in adults aged ≥19 years in South Korea...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29094263/exophiala-dermatitidis-revealing-cystic-fibrosis-in-adult-patients-with-chronic-pulmonary-disease
#11
Frédéric Grenouillet, Bernard Cimon, Heloise Pana-Katatali, Christine Person, Marie Gainet-Brun, Marie-Claire Malinge, Yohann Le Govic, Bénédicte Richaud-Thiriez, Jean-Philippe Bouchara
Cystic fibrosis (CF) is a genetic inherited disease due to mutations in the gene cystic fibrosis transmembrane conductance regulator (CFTR). Because of the huge diversity of CFTR mutations, the CF phenotypes are highly heterogeneous, varying from typical to mild form of CF, also called atypical CF. These atypical features are more frequently diagnosed at adolescence or adulthood, and among clinical signs and symptoms leading to suspect a mild form of CF, colonization or infection of the respiratory tract due to well-known CF pathogens should be a warning signal...
November 1, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29091912/diabetes-mellitus-increases-the-susceptibility-to-encephalitozoonosis-in-mice
#12
Aldo Francisco Neto, Paulo Ricardo Dell'Armelina Rocha, Elizabeth Christina Perez, José Guilherme Xavier, Giovani Bravin Peres, Diva Denelle Spadacci-Morena, Anuska Marcelino Alvares-Saraiva, Maria Anete Lallo
Microsporidiosis are diseases caused by opportunistic intracellular fungi in immunosuppressed individuals, as well as in transplanted patients, the elderly and children, among others. Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia and decreased T cell response, neutrophil function, humoral immunity failure, increasing the susceptibility to infections. Here, we investigated the susceptibility of streptozotocin (STZ)-induced type I diabetic and/or immunosuppressed mice to encephalitozoonosis by Encephalitozoon cuniculi...
2017: PloS One
https://www.readbyqxmd.com/read/29089174/clinical-outcomes-of-elderly-patients-with-bloodstream-infections-due-to-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-in-an-italian-internal-medicine-ward
#13
Simone Meini, Raffaele Laureano, Carlo Tascini, Fabio Arena, Lucia Fani, Anna Frullini, Maria Teresa Passaleva, Anna Teresa Roberts, Dario Mannini, Francesco Sbrana, Andrea Ripoli, Gian Maria Rossolini
PURPOSE: Infections caused by ESBL-producing Enterobacteriaceae (ESBL-EB) are a major health problem, but data regarding elderly patients is lacking. METHODS: We performed a retrospective observational study quantifying the effects of antimicrobial treatment and primary infection site on clinical outcomes in an historical case series of 42 patients aged 80.7±10years admitted to an Internal Medicine ward in Italy for ESBL-EB bloodstream infections (BSI). RESULTS: At multivariate risk analysis, we found that urinary tract as primary infection site (RR=0...
October 28, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29088952/significant-increase-in-acute-subdural-hematoma-in-octo-and-nonagenarians-surgical-treatment-functional-outcome-and-predictors-in-this-patient-cohort
#14
Sae-Yeon Won, Daniel Dubinski, Nina Brawanski, Adam Strzelczyk, Volker Seifert, Thomas M Freiman, Juergen Konczalla
OBJECTIVE Acute subdural hematoma (aSDH) is a common disease increasing in prevalence given the demographic growth of the aging population. Yet, the benefit of surgical treatment for aSDH and the subsequent functional outcome in elderly patients (age ≥ 80 years) remain unclear. Therefore, the aims of this study were to evaluate the incidence of aSDH in patients 80 years or older, determine overall functional outcome, identify predictors of an unfavorable or favorable outcome, and establish specific risk factors for seizures...
November 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29078905/sphingosine-rescues-aged-mice-from-pulmonary-pseudomonas-infection
#15
Teresa C Rice, Amanda M Pugh, Aaron P Seitz, Erich Gulbins, Vanessa Nomellini, Charles C Caldwell
BACKGROUND: Bacterial lung infection is a leading cause of death for those 65 y or older, often requiring intensive care unit admission and mechanical ventilation, which consumes considerable health care resources. Although administration of antibiotics is the standard of care for bacterial pneumonia, its overuse has led to the emergence of multidrug resistant organisms. Therefore, alternative strategies to help minimize the effects of bacterial pneumonia in the elderly are necessary...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29066003/clinical-outcomes-after-burns-in-elderly-patients-over-70-years-a-17-year-retrospective-analysis
#16
Gregg Dexter, Sachin Patil, Kanwardeep Singh, Michael A Marano, Robin Lee, Sylvia J Petrone, Ronald S Chamberlain
INTRODUCTION: In the United Stated population >70years is likely to double by the year 2050. Elderly population (>70years) are most vulnerable to burns and outcomes following such injuries in this special group is poorly studied. This study aimed to look at outcomes following burns in patients >70years over a period of 17 years. MATERIALS AND METHODS: Data on 6512 patients admitted to a Level I Burn Center between 1995 and 2011 was analyzed. Age, gender, ethnicity, TBSA, burn etiology, hospital and burn intensive care unit (ICU) length of stay (LOS) and status at discharge were abstracted...
October 20, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29064347/excess-mortality-in-italy-should-we-care-about-low-influenza-vaccine-uptake
#17
Francia Fausto, Pandolfi Paolo, Odone Anna, Signorelli Carlo
AIMS: The aims of this study were to explore 2015 mortality data further and to assess excess deaths' determinants. METHODS: We analysed data from a large metropolitan area in the north of Italy, the city of Bologna. We took advantage of a comprehensive local-level database and merged three different data sources to analitically explore reported 2014-2015 excess mortality and its determinants. Effect estimates were derived from multivariable Poisson regression analysis, according to vaccination status and frailty index...
October 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29057257/serological-analysis-and-drug-resistance-of-chlamydia-pneumoniae-and-mycoplasma-pneumoniae-in-4500-healthy-subjects-in-shenzhen-china
#18
Dong Du, Shuping Liao, Yan Wu, Yang Jiao, Di Wu, Weiqing Wu, Dapeng Yu
OBJECTIVE: To understand the prevalence and distribution of Chlamydia pneumoniae (CP) and Mycoplasma pneumoniae (MP) in the population and to provide a basis for the prevention and treatment of respiratory tract infection. METHODS: This study included a total of 4500 healthy subjects who were given physical examination in Shenzhen People's Hospital from January to December in 2016. Venous blood was drawn from people to detect the MP- and CP-specific IgG and IgM in the serum using chemiluminescence immunoassay (CLIA)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29055803/optimal-blood-pressure-decreases-acute-kidney-injury-after-gastrointestinal-surgery-in-elderly-hypertensive-patients-a-randomized-study-optimal-blood-pressure-reduces-acute-kidney-injury
#19
Xiujuan Wu, Zongming Jiang, Jing Ying, Yangyang Han, Zhonghua Chen
STUDY OBJECTIVE: To determine the appropriate mean arterial pressure (MAP) control level for elderly patients with hypertension during the perioperative period. DESIGN: A prospective, randomized study. SETTING: Three teaching hospitals in China. PATIENTS: Six hundred seventy-eight elderly patients with chronic hypertension undergoing major gastrointestinal surgery. INTERVENTIONS: Patients were randomly allocated to three groups and the target MAP level was strictly controlled to one of three levels: level I (65-79mmHg), level II (80-95mmHg), or level III (96-110mmHg)...
December 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29053769/relationships-of-variations-in-the-tongue-microbiota-and-pneumonia-mortality-in-nursing-home-residents
#20
Shinya Kageyama, Toru Takeshita, Michiko Furuta, Mikiko Tomioka, Mikari Asakawa, Shino Suma, Kenji Takeuchi, Yukie Shibata, Yasuyuki Iwasa, Yoshihisa Yamashita
Background: Aspiration of oral debris, containing dense oral bacteria, is a major cause of pneumonia in elderly adults. This study investigated the relationship between tongue microbiota composition and incidence of pneumonia-related deaths, in nursing home residents. Methods: The subjects were assessed for health conditions, including their tongue microbiota, at baseline. We determined tongue microbiota profiles by 16S ribosomal RNA gene sequencing and clustering approach...
October 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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