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https://www.readbyqxmd.com/read/27936497/pro-inflammatory-cytokine-ifn%C3%AE-and-microbiome-derived-metabolites-dictate-epigenetic-switch-between-foxp3-isoforms-in-celiac-disease-regulation-of-foxp3-isoforms-in-celiac-disease
#1
Gloria Serena, Shu Yan, Stephanie Camhi, Shilpi Patel, Rosiane S Lima, Anna Sapone, Maureen M Leonard, Rupa Mukherjee, Barbara J Nath, Karen M Lammers, Alessio Fasano
Celiac disease (CD) is an autoimmune enteropathy triggered by gluten and characterized by a strong Th1/Th17 immune response in the small intestine. Treg cells are CD4(+) CD25(++) FOXP3(+) cells that regulate the immune response. Conversely to its counterpart, FOXP3 full length (FL), the alternatively spliced isoform FOXP3 Δ2 cannot properly down-regulate Th17 driven immune response. Since the active state of CD has been associated with impairments in Treg cell function, we aimed at determining whether imbalances between FOXP3 isoforms may be associated with the disease...
December 9, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27936480/treatment-of-fulminant-acute-hepatitis-b-with-nucles-t-id-analogues-is-safe-and-does-not-lead-to-secondary-chronification-of-hepatitis-b
#2
C Jochum, F Maischack, O E Anastasiou, J Verheyen, J Timm, L Bechmann, G Gerken, A Canbay
Background: Acute hepatitis B virus (HBV) infection is still a major cause of acute liver failure (ALF), necessitating a high rate of emergency liver transplantation (LTx). Acute infection is followed by high viral replication rates leading to hepatocyte death and, ultimately, ALF. The objective of treating HBV-induced ALF thus is to eliminate, or significantly suppress, HBV replication and therefore reduce cell death and support regeneration. Objective: In this retrospective study, we want to evaluate the timing, the safety, and the long-term virological outcome of this approach...
December 2016: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/27936471/prevalence-of-lens-opacities-in-adult-chinese-americans-the-chinese-american-eye-study-ches
#3
Rohit Varma, Jie Sun, Mina Torres, Shuang Wu, Chunyi Hsu, Stanley Paul Azen, Roberta McKean-Cowdin
Purpose: We determined the age- and sex-specific prevalence of posterior subcapsular (PSC), nuclear, cortical, and mixed lens opacities in a population-based sample of Chinese-American adults. Methods: A population-based sample of Chinese-Americans 50 years and older, from 10 census tracts in Monterey Park, CA, USA, underwent a detailed interview and a comprehensive clinical examination that included assessment of different types of lens opacities by the slit-lamp-based Lens Opacities Classification System II (LOCS II)...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27936435/bilobalide-abates-inflammation-insulin-resistance-and-secretion-of-angiogenic-factors-induced-by-hypoxia-in-3t3-l1-adipocytes-by-controlling-nf-%C3%AE%C2%BAb-and-jnk-activation
#4
A Priyanka, G Sindhu, G L Shyni, M R Preetha Rani, V M Nisha, K G Raghu
Obesity leads to inflammation and insulin resistance in adipose tissue. Hypoxia, observed in obese adipose tissue is suggested as a major cause of inflammation and insulin resistance in obesity. However, the role of hypoxia in adipose tissue during obesity and insulin resistance was not well established. Here we mainly explored the crosstalk between hypoxia induced inflammation, and insulin resistance and also secretion of angiogenic factors in 3T3-L1 adipocytes and possible reversal with bilobalide. Hypoxia for 24h significantly (P≤0...
December 6, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27936395/population-based-report-on-health-related-quality-of-life-in-adolescents-born-very-preterm
#5
Giancarlo Natalucci, Hans Ulrich Bucher, Michael Von Rhein, Cristina Borradori Tolsa, Beatrice Latal, Mark Adams
BACKGROUND: As the survival rate of preterm infants constantly improves, knowledge on the impact of prematurity on long-term health-related quality of life (HRQoL) is important for clinical and parental guidance. We aimed to assess HRQoL in a national cohort of young adolescents born very preterm, and to identify predictors for poorer HRQoL. PATIENTS AND METHODS: All surviving Swiss live-born children below 30weeks of gestation during the year 2000 (290 subjects) were contacted at age 12years, together with their parents (262 families)...
December 6, 2016: Early Human Development
https://www.readbyqxmd.com/read/27936362/prevalence-of-self-reported-prescription-drug-use-in-a-national-sample-of-u-s-drivers
#6
Tara Kelley-Baker, Geetha Waehrer, Robin A Pollini
OBJECTIVE: Drug-involved driving has become an increasing concern. Although the focus has been on illegal drugs, there is evidence that prescribed medications can impair driving ability. The purpose of this study was to determine the self-reported prevalence of prescription drug use, including medical and nonmedical use, among a nationally representative sample of drivers and to report related driver characteristics. METHOD: As part of the 2013-2014 National Roadside Survey, drivers from 60 sites were randomly recruited and asked to complete a survey on prescription drug use...
January 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27936296/antiangiogenic-and-toxic-effects-of-genistein-usnic-acid-and-their-copper-complexes-in-zebrafish-embryos-at-different-developmental-stages
#7
Heidrun Draut, Tobias Rehm, Gerrit Begemann, Rainer Schobert
Angiogenesis plays a major role in the normal embryonic development and in diseases such as cancer. Drugs that control angiogenesis are an alternative way to tackle this disease. The polyphenols usnic acid 3, genistein 5, and daidzein 6 were tested for antiangiogenic and unwanted effects in zebrafish embryos whose blood vessel system resembles that of mammals. The established tyrosine kinase inhibitors axitinib 1 and tyrphostin AG490 2 were included for comparison. All compounds except 6 caused distinct antiangiogenic effects such as a concentration-dependent reduction of intersegmental vessels, dorsal longitudinal anastomotic vessels, subintestinal veins and secondary sprouts...
December 9, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27936277/algorithm-driven-dosage-decisions-ad3-optimizing-treatment-for-children-with-language-impairment
#8
Laura M Justice, Jessica Logan, Hui Jiang, Mary Beth Schmitt
Background: This study was designed to provide recommended amounts of treatment to achieve the optimal amount of language gain for children with language impairment. Method: The authors retrospectively analyzed treatment outcomes for 233 children for delivered dose, intensity, and cumulative intensity of therapy. The steps of the analytical process they applied to arrive at algorithms for recommended amounts of treatment were (1) multilevel modeling to predict children's language gains from the 3 intensity parameters and (2) extraction of regression weights to create a recommended amount of treatment...
December 9, 2016: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/27936235/correction-catalise-a-multinational-and-multidisciplinary-delphi-consensus-study-identifying-language-impairments-in-children
#9
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0158753.].
2016: PloS One
https://www.readbyqxmd.com/read/27936218/a-key-role-for-inhibins-in-dendritic-cell-maturation-and-function
#10
Roxana Olguín-Alor, Marisol de la Fuente-Granada, Laura C Bonifaz, Laura Antonio-Herrera, Eduardo A García-Zepeda, Gloria Soldevila
Inhibins are members of the TGFβ superfamily, which regulate many cellular processes including differentiation, proliferation, survival and apoptosis. Although initially described as hormones regulating the hypothalamus-pituitary-gonadal axis, based on their ability to antagonize Activins, our group has recently reported that they play a role in thymocyte differentiation and survival, as well as in thymic stromal cell maturation and nTreg generation. Here, we used Inhibin knock out mice (Inhα-/-) to investigate the role of Inhibins in peripheral dendritic cell maturation and function...
2016: PloS One
https://www.readbyqxmd.com/read/27936197/vascular-tone-regulation-induced-by-c-type-natriuretic-peptide-differences-in-endothelium-dependent-and-independent-mechanisms-involved-in-normotensive-and-spontaneously-hypertensive-rats
#11
Carolina Caniffi, Flavia M Cerniello, María N Gobetto, María L Sueiro, María A Costa, Cristina Arranz
Given that the role of C-type natriuretic peptide (CNP) in the regulation of vascular tone in hypertensive states is unclear, we hypothesized that impaired response of the nitric oxide system to CNP in spontaneously hypertensive rats (SHR) could affect vascular relaxation induced by the peptide in this model of hypertension, and that other endothelial systems or potassium channels opening could also be involved. We examined the effect of CNP on isolated SHR aortas, and the hindlimb vascular resistance (HVR) in response to CNP administration compared to normotensive rats...
2016: PloS One
https://www.readbyqxmd.com/read/27936195/plaque-characteristics-in-coronary-artery-disease-patients-with-impaired-glucose-tolerance
#12
Keishi Suzuki, Hitoshi Takano, Yoshiaki Kubota, Keisuke Inui, Shunichi Nakamura, Yukichi Tokita, Koji Kato, Kuniya Asai, Wataru Shimizu
BACKGROUND: Impaired glucose tolerance (IGT) patients are known to have a high risk of cardiovascular events and their prognosis has been reported to be poor. The present study aimed to compare coronary plaque characteristics among coronary artery disease (CAD) patients with normal glucose tolerance (NGT), those with IGT, and those with diabetes mellitus (DM) by using optical coherence tomography (OCT). METHODS: The present study included 101 coronary artery disease patients (mean age, 67...
2016: PloS One
https://www.readbyqxmd.com/read/27936186/maternal-separation-impairs-cocaine-induced-behavioural-sensitization-in-adolescent-mice
#13
Irene Gracia-Rubio, Olga Valverde, Elena Martinez-Laorden, Maria Moscoso-Castro, M Victoria Milanés, M Luisa Laorden
Adverse early-life conditions induce persistent disturbances that give rise to negative emotional states. Therefore, early life stress confers increased vulnerability to substance use disorders, mainly during adolescence as the brain is still developing. In this study, we investigated the consequences of maternal separation, a model of maternal neglect, on the psychotropic effects of cocaine and the neuroplasticity of the dopaminergic system. Our results show that mice exposed to maternal separation displayed attenuated behavioural sensitization, while no changes were found in the rewarding effects of cocaine in the conditioned place preference paradigm and in the reinforcing effects of cocaine in the self-administration paradigm...
2016: PloS One
https://www.readbyqxmd.com/read/27936181/in-vivo-modelling-of-atp1a3-g316s-induced-ataxia-in-c-elegans-using-crispr-cas9-mediated-homologous-recombination-reveals-dominant-loss-of-function-defects
#14
Altar Sorkaç, Ivan C Alcantara, Anne C Hart
The NIH Undiagnosed Diseases Program admitted a male patient with unclassifiable late-onset ataxia-like symptoms. Exome sequencing revealed a heterozygous de novo mutation converting glycine 316 to serine in ATP1A3, which might cause disease. ATP1A3 encodes the Na+/K+ ATPase pump α3-subunit. Using CRISPR/Cas9-mediated homologous recombination for genome editing, we modelled this putative disease-causing allele in Caenorhabditis elegans, recreating the patient amino acid change in eat-6, the orthologue of ATP1A3...
2016: PloS One
https://www.readbyqxmd.com/read/27936154/retinal-morphology-and-sensitivity-are-primarily-impaired-in-eyes-with-neuromyelitis-optica-spectrum-disorder-nmosd
#15
Ryutaro Akiba, Hirotaka Yokouchi, Masahiro Mori, Toshiyuki Oshitari, Takayuki Baba, Setsu Sawai, Satoshi Kuwabara, Shuichi Yamamoto
BACKGROUND: Previous studies of neuromyelitis optica spectrum disorder (NMOSD) using spectral domain optical coherence tomography (SD-OCT) showed that the outer nuclear layer (ONL) in eyes without a history of optic neuritis (ON) was thinner than that of healthy controls. It remains unclear whether the ONL thinning is caused by a direct attack on the retina by an autoantibody or a retrograde degeneration. OBJECTIVE: To determine the mechanisms involved in the retinal damage in eyes with NMOSD without ON...
2016: PloS One
https://www.readbyqxmd.com/read/27936113/preoperative-csf-melatonin-concentrations-and-the-occurrence-of-delirium-in-older-hip-fracture-patients-a-preliminary-study
#16
Rikie M Scholtens, Sophia E J A de Rooij, Annelies E Vellekoop, Bart C Vrouenraets, Barbara C van Munster
BACKGROUND: Delirium is characterized by disturbances in circadian rhythm. Melatonin regulates our circadian rhythm. Our aim was to compare preoperative cerebrospinal fluid (CSF) melatonin levels in patients with and without postoperative delirium. METHODS: Prospective cohort study with hip fracture patients ≥ 65 years who were acutely admitted to the hospital for surgical treatment and received spinal anaesthesia. CSF was collected after cannulation, before administering anaesthetics...
2016: PloS One
https://www.readbyqxmd.com/read/27936096/factors-associated-with-disability-in-rural-bangladesh-bangladesh-population-based-diabetes-and-eye-study-bpdes
#17
Fakir M Amirul Islam, Jahar L Bhowmik, Silvia Z Islam, Andre M N Renzaho, Janet E Hiller
BACKGROUND: To assess factors associated with disability in a rural district of Bangladesh. METHODS: Using a population-based systematic sampling technique, data were collected from 3104 adults aged ≥ 30 years from the Banshgram union of Narail district. Data collected included an interviewer administered questionnaire to report physical disabilities including impairment that prevents engagement with paid work, visual, hearing, and mobility as well as mental disabilities...
2016: PloS One
https://www.readbyqxmd.com/read/27936074/association-between-metabolic-syndrome-and-cognitive-impairment-after-acute-ischemic-stroke-a-cross-sectional-study-in-a-chinese-population
#18
Pan Li, Wei Quan, Da Lu, Yan Wang, Hui-Hong Zhang, Shuai Liu, Rong-Cai Jiang, Yu-Ying Zhou
BACKGROUND AND OBJECTIVES: Metabolic syndrome (MetS), a risk factor for many vascular conditions, is associated with vascular cognitive disorders. The objective of the present study was to explore the associations of MetS and its individual components with the risks of cognitive impairment and neurological dysfunction in patients after acute stroke. METHODS: This cross-sectional study enrolled 840 patients ranging in age from 53 to 89 years from the Tianjin area of North China...
2016: PloS One
https://www.readbyqxmd.com/read/27936060/a-non-linear-scoring-approach-for-evaluating-balance-classification-of-elderly-as-fallers-and-non-fallers
#19
Julien Audiffren, Ioannis Bargiotas, Nicolas Vayatis, Pierre-Paul Vidal, Damien Ricard
Almost one third of population 65 years-old and older faces at least one fall per year. An accurate evaluation of the risk of fall through simple and easy-to-use measurements is an important issue in current clinic. A common way to evaluate balance in posturography is through the recording of the centre-of-pressure (CoP) displacement (statokinesigram) with force platforms. A variety of indices have been proposed to differentiate fallers from non fallers. However, no agreement has been reached whether these analyses alone can explain sufficiently the complex synergies of postural control...
2016: PloS One
https://www.readbyqxmd.com/read/27936058/modeling-the-role-of-lanthionine-synthetase-c-like-2-lancl2-in-the-modulation-of-immune-responses-to-helicobacter-pylori-infection
#20
Andrew Leber, Josep Bassaganya-Riera, Nuria Tubau-Juni, Victoria Zoccoli-Rodriguez, Monica Viladomiu, Vida Abedi, Pinyi Lu, Raquel Hontecillas
Immune responses to Helicobacter pylori are orchestrated through complex balances of host-bacterial interactions, including inflammatory and regulatory immune responses across scales that can lead to the development of the gastric disease or the promotion of beneficial systemic effects. While inflammation in response to the bacterium has been reasonably characterized, the regulatory pathways that contribute to preventing inflammatory events during H. pylori infection are incompletely understood. To aid in this effort, we have generated a computational model incorporating recent developments in the understanding of H...
2016: PloS One
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