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Thuy Tran

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https://www.readbyqxmd.com/read/28724314/developing-combination-of-artesunate-with-paclitaxel-loaded-into-poly-d-l-lactic-co-glycolic-acid-nanoparticle-for-systemic-delivery-to-exhibit-synergic-chemotherapeutic-response
#1
Bao Ngoc Tran, Hanh Thuy Nguyen, Jong Oh Kim, Chul Soon Yong, Chien Ngoc Nguyen
OBJECTIVES: Paclitaxel (PTX) has been indicated for treatment of a variety of solid tumors, while artesunate (ART) has been reported to have the potential for use in combination chemotherapy. In this study, the combination of ART and PTX was prepared in nanoparticle to induce the synergic effect and improve therapeutic efficiency in treatment of breast cancer Methods: Dual anti-cancer agents (PTX and ART) were loaded into Poly-D,L-lactic-co-glycolic acid (PLGA) nanoparticle (NP) by solvent evaporation technique from oil in water emulsion, stabilized with Tween 80...
July 20, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28719771/prevalence-of-self-treatment-practice-and-related-factors-among-workers-aged-15-to-60-years-in-chi-linh-town-hai-duong-province-vietnam
#2
Thuy Quynh Nguyen, Thi Thu Thuy Tran, Thi Vui Le, Thi Tu Bui Quyen, Van Hung Trinh, Huu Bich Tran
Self-treatment is particularly prevalent in Vietnam. However, the prevalence of this practice among the working population is unclear. This study aims to describe the prevalence of self-treatment and related factors among workers aged 15 to 60 years in the suburban area of Chi Linh, Hai Duong, Vietnam. Secondary data of 3128 respondents was retrieved from the CHILILAB HDSS 2016 survey for analysis using logistic regression with a significance level of .05. Results show that 47.5% of respondents treated themselves at least once during one previous year...
July 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28719767/capacity-of-commune-health-stations-in-chi-linh-district-hai-duong-province-for-prevention-and-control-of-noncommunicable-diseases
#3
Nguyen Thi Thuy Nga, Bui Thi My Anh, Nguyen Nguyen Ngoc, Dang Minh Diem, Vu Duy Kien, Tran Bich Phuong, Tran Quynh Anh, Hoang Van Minh
The primary health care system in Vietnam has been playing an important role in prevention and control of diseases. This study aimed to describe the capacity of commune health stations in Chi Linh district, Hai Duong province for prevention and control of noncommunicable diseases (NCDs). A mixed-methods (quantitative and qualitative approaches) approach was applied to collect data in 20 commune health stations. The participants, including health workers, stakeholders, and patients with NCDs, were selected for the study...
July 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28719300/chikungunya-and-zika-virus-cases-detected-against-a-backdrop-of-endemic-dengue-transmission-in-vietnam
#4
Nguyen Than Ha Quyen, Duong Thi Hue Kien, Maia Rabaa, Nguyen Minh Tuan, Tran Thuy Vi, Le Van Tan, Nguyen Thanh Hung, Ha Manh Tuan, Ta Van Tram, Nguyen Le Da Ha, Han Khoi Quang, Nguyen Quoc Doanh, Nguyen Van Vinh Chau, Bridget Wills, Cameron P Simmons
Between 2010 and 2014, four chikungunya and two Zika virus infections were identified among 8,105 febrile children in southern Vietnam. Zika viruses were linked to French Polynesian strains, chikungunya to Cambodian strains. Against a backdrop of endemic dengue transmission, chikungunya and Zika present an additional arboviral disease burden in Vietnam.
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28693435/data-cleaning-and-management-protocols-for-linked-perinatal-research-data-a-good-practice-example-from-the-smoking-mums-maternal-use-of-medications-and-safety-study
#5
Duong Thuy Tran, Alys Havard, Louisa R Jorm
BACKGROUND: Data cleaning is an important quality assurance in data linkage research studies. This paper presents the data cleaning and preparation process for a large-scale cross-jurisdictional Australian study (the Smoking MUMS Study) to evaluate the utilisation and safety of smoking cessation pharmacotherapies during pregnancy. METHODS: Perinatal records for all deliveries (2003-2012) in the States of New South Wales (NSW) and Western Australia were linked to State-based data collections including hospital separation, emergency department and death data (mothers and babies) and congenital defect notifications (babies in NSW) by State-based data linkage units...
July 11, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28691856/chemical-constituents-from-the-leaves-of-pinus-dalatensis-ferr%C3%A3
#6
Nguyen Hoang Sa, Nguyen Thanh Tam, Nguyen Thi Hoang Anh, Tran Duc Quan, Dao Duc Thien, Dinh Thi Phong, Tran Van Sung, Trinh Thi Thuy
A phytochemical study of n-hexane and ethyl acetate extracts of Pinus dalatensis Ferré leaves led to the isolation of 11 compounds, including one caryolane sesquiterpenoid (1), five labdane diterpenoids (2, 3, 4, 5, 6), one serratane triterpenoid (7), one diacylated flavonoid glucoside (8), one stilbenoid (9) and two sterols (10, 11). The structural characterisation of the isolated compounds was elucidated by spectroscopic data and comparison with the literature report on the chemical constituents from Pinus dalatensis Ferré...
July 10, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28688956/flavonoid-glycosides-from-barringtonia-acutangula
#7
Le Thi Vien, Quach Thi Thanh Van, Tran Thi Hong Hanh, Phan Thi Thanh Huong, Nguyen Thi Kim Thuy, Nguyen The Cuong, Nguyen Hai Dang, Nguyen Van Thanh, Nguyen Xuan Cuong, Nguyen Hoai Nam, Phan Van Kiem, Chau Van Minh
Using various chromatographic separation techniques, ten flavonoid glycosides, including six new compounds namely barringosides A-F (1-6), were isolated from a methanol extract of the Barringtonia acutangula leaves. The structure elucidation was confirmed by spectroscopic analyses, including 1D and 2D NMR, and HR ESI MS. Their inhibitory effects on LPS-induced NO production in RAW264.7 cells were also evaluated. Among the isolated compounds, quercetin 3-O-β-d-(6-p-hydroxybenzoyl)galactopyranoside (9) showed significant effect with an IC50 of 20...
June 27, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28684867/combined-magnetomotive-ultrasound-pet-ct-and-mr-imaging-of-68-ga-labelled-superparamagnetic-iron-oxide-nanoparticles-in-rat-sentinel-lymph-nodes-in-vivo
#8
Maria Evertsson, Pontus Kjellman, Magnus Cinthio, Roger Andersson, Thuy A Tran, Rene In't Zandt, Gustav Grafström, Hanna Toftevall, Sarah Fredriksson, Christian Ingvar, Sven-Erik Strand, Tomas Jansson
Current methods for intra-surgical guidance to localize metastases at cancer surgery are based on radioactive tracers that cause logistical challenges. We propose the use of a novel ultrasound-based method, magnetomotive ultrasound (MMUS) imaging that employ a nanoparticle-based contrast agent that also may be used for pre-operative PET/MRI imaging. Since MMUS is radiation free, this eliminates the dependence between pre- and intra-operative imaging and the radiation exposure for the surgical staff. This study investigates a hypothetical clinical scenario of pre-operative PET imaging, combined with intra-operative MMUS imaging, implemented in a sentinel lymph node (SLN) rat model...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28683274/sulfated-polysaccharides-of-the-vietnamese-brown-alga-sargassum-aquifolium-fucales-sargassaceae
#9
Maria I Bilan, Nadezhda E Ustyuzhanina, Alexander S Shashkov, Thi Thu Thuy Thanh, Minh Ly Bui, Thi Thanh Van Tran, Van Nguyen Bui, Anatolii I Usov
A fucoidan preparation named FSA was isolated from the brown alga Sargassum aquifolium collected from the coastal waters of Vietnam. l-Fucose, d-galactose, d-mannose, d-glucuronic acid, d-xylose, and sulfate were found to be the main constituents of FSA. The preparation was fractionated by anion-exchange chromatography on DEAE-Sephacel eluted stepwise with 0.5, 1.0, 1.5, and 2.0 M NaCl to give four fractions differing in monosaccharide composition and degree of sulfation. Their NMR spectra were too complex to be completely interpreted...
June 27, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28679906/comparison-of-grouping-methods-for-template-extraction-from-va-medical-record-text
#10
Andrew M Redd, Adi V Gundlapalli, Guy Divita, Le-Thuy Tran, Warren B P Pettey, Matthew H Samore
We investigate options for grouping templates for the purpose of template identification and extraction from electronic medical records. We sampled a corpus of 1000 documents originating from Veterans Health Administration (VA) electronic medical record. We grouped documents through hashing and binning tokens (Hashed) as well as by the top 5% of tokens identified as important through the term frequency inverse document frequency metric (TF-IDF). We then compared the approaches on the number of groups with 3 or more and the resulting longest common subsequences (LCSs) common to all documents in the group...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28642202/engineering-of-multifunctional-temperature-sensitive-liposomes-for-synergistic-photothermal-photodynamic-and-chemotherapeutic-effects
#11
Tuan Hiep Tran, Hanh Thuy Nguyen, Nam Van Le, Thi Thu Phuong Tran, Jong Seong Lee, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Heterogeneity of cancer cells and drug resistance require multiple therapeutic approaches for comprehensive treatment. In this study, temperature-sensitive liposomes containing anti-cancer agent tanespimycin (17-AAG) and photosensitizer IR 820 were developed for combination of phototherapy and chemotherapy. The temperature-sensitive liposomes composed of DPPC, cholesterol, DSPE-PEG, 17-AAG, and IR 820 (LP-AI) at weight ratio of 35/15/3/2/2 were formulated as a thin film using extrusion and evaluated for particle size, morphology and drug release profile...
June 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28614691/a-trial-of-itraconazole-or-amphotericin-b-for-hiv-associated-talaromycosis
#12
RANDOMIZED CONTROLLED TRIAL
Thuy Le, Nguyen Van Kinh, Ngo T K Cuc, Nguyen L N Tung, Nguyen T Lam, Pham T T Thuy, Do D Cuong, Pham T H Phuc, Vu H Vinh, Doan T H Hanh, Vu Van Tam, Nguyen T Thanh, Tran P Thuy, Nguyen T Hang, Hoang B Long, Ho T Nhan, Heiman F L Wertheim, Laura Merson, Cecilia Shikuma, Jeremy N Day, Nguyen V V Chau, Jeremy Farrar, Guy Thwaites, Marcel Wolbers
BACKGROUND: Talaromyces marneffei infection is a major cause of human immunodeficiency virus (HIV)-related death in South and Southeast Asia. Guidelines recommend initial treatment with amphotericin B deoxycholate, but this drug has substantial side effects, a high cost, and limited availability. Itraconazole is available in oral form, is associated with fewer unacceptable side effects than amphotericin, and is widely used in place of amphotericin; however, clinical trials comparing these two treatments are lacking...
June 15, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28597397/protein-kinase-c%C3%AE-gene-depletion-protects-against-methamphetamine-induced-impairments-in-recognition-memory-and-erk1-2-signaling-via-upregulation-of-glutathione-peroxidase-1-gene
#13
The-Vinh Tran, Eun-Joo Shin, Lan Thuy Ty Nguyen, Youngho Lee, Dae-Joong Kim, Ji Hoon Jeong, Choon-Gon Jang, Seung-Yeol Nah, Kazuya Toriumi, Toshitaka Nabeshima, Kiyofumi Yamada, Hyoung-Chun Kim
Accumulating evidence has suggested that repeated treatment with methamphetamine (MA) resulted in cognitive impairments. Importantly, we show that selective upregulation of protein kinase Cδ (PKCδ) in the prefrontal cortex (PFC) of wild-type mice persisted for 28 days post withdrawal of MA. On day 28, the MA-induced increase in phospho-PKCδ expression and decrease in phospho-ERK1/2 expression were significantly attenuated by both the Src inhibitor PP2 and the dopamine D1 receptor antagonist SCH 23390. However, neither protein kinase A inhibitor H89 nor calmodulin-dependent protein kinase II inhibitor KN93 attenuated MA-induced alterations in phospho-PKCδ expression and phospho-ERK1/2 expression...
June 9, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28577575/identification-of-sympatric-cryptic-species-of-aedes-albopictus-subgroup-in-vietnam-new-perspectives-in-phylosymbiosis-of-insect-vector
#14
Guillaume Minard, Van Tran Van, Florence Hélène Tran, Christian Melaun, Sven Klimpel, Lisa Katharina Koch, Khanh Ly Huynh Kim, Trang Huynh Thi Thuy, Huu Tran Ngoc, Patrick Potier, Patrick Mavingui, Claire Valiente Moro
BACKGROUND: The Aedes (Stegomyia) albopictus subgroup includes 11 cryptic species of which Ae. albopictus is the most widely distributed. Its global expansion associated with a documented vector competence for several emerging arboviruses raise obvious concerns in the recently colonized regions. While several studies have provided important insights regarding medical importance of Ae. albopicus, the investigations of the other sibling species are scarce. In Asia, indigenous populations within the Ae...
June 2, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28573923/combined-photothermal-and-photodynamic-therapy-by-hyaluronic-acid-decorated-polypyrrole-nanoparticles
#15
Tuan Hiep Tran, Hanh Thuy Nguyen, Thi Thu Phuong Tran, Sae Kwang Ku, Jee-Heon Jeong, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
AIM: To develop a nanoparticle-based platform using polypyrrole and IR-780 for effective combined photothermal and photodynamic therapy. MATERIALS & METHODS: IR-780 was loaded in a poly(lactic-co-glycolic acid) core, decorated with polypyrrole shells and hyaluronic acid (IPPH). Physicochemical properties and in vitro and in vivo anticancer effects of these nanoparticles were evaluated. RESULTS: The resulting IPPHs were spherical, small and negatively charged...
June 2, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28549906/using-potentiometric-free-drug-sensors-to-determine-the-free-concentration-of-ionizable-drugs-in-colloidal-systems
#16
Thuy Tran, Anjan Chakraborty, Xi Xi, Hugo Bohets, Claus Cornett, Konstantin Tsinman, Thomas Rades, Anette Müllertz
The present study investigates the use of free drug sensors (FDS) to measure free ionized drug concentrations in colloidal systems, including micellar solutions, emulsions, and lipid formulations during in vitro lipolysis. Diphenhydramine hydrochloride (DPH) and loperamide hydrochloride (LOP) were selected as model drugs. Self-diffusion nuclear magnetic resonance studies were performed and confirmed the entrapment of drugs in micelles in Brij 35 and sodium taurodeoxycholate (TDC)/phosphatidylcholine (PC) micellar solutions...
May 23, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28549744/survival-after-resection-of-perihilar-cholangiocarcinoma-in%C3%A2-patients-with-lymph-node-metastases
#17
Stefan Buettner, Jeroen L A van Vugt, Marcia P Gaspersz, Robert J S Coelen, Eva Roos, Tim A Labeur, Georgios A Margonis, Cecilia G Ethun, Shishir K Maithel, George Poultsides, Thuy Tran, Kamran Idrees, Chelsea A Isom, Ryan C Fields, Bradley A Krasnick, Sharon M Weber, Ahmed Salem, Robert C G Martin, Charles R Scoggins, Perry Shen, Harveshp D Mogal, Carl Schmidt, Eliza Beal, Ioannis Hatzaras, Rivfka Shenoy, Jan N M IJzermans, Thomas M van Gulik, Timothy M Pawlik, Bas Groot Koerkamp
BACKGROUND: The aim of this study was to compare patients with PHC with lymph node metastases (LN+) who underwent a resection with patients who did not undergo resection because of locally advanced disease at exploratory laparotomy. METHODS: Consecutive LN+ patients who underwent a resection for PHC in 12 centers were compared with patients who did not undergo resection because of locally advanced disease at exploratory laparotomy in 2 centers. RESULTS: In the resected cohort of 119 patients, the median overall survival (OS) was 19 months and the estimated 1-, 3- and 5-year OS was 69%, 27% and 13%, respectively...
May 23, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28536161/correction-for-evans-et-al-informing-antibiotic-treatment-decisions-evaluating-rapid-molecular-diagnostics-to-identify-susceptibility-and-resistance-to-carbapenems-against-acinetobacter-spp-in-primers-iii
#18
Scott R Evans, Andrea M Hujer, Hongyu Jiang, Carol B Hill, Kristine M Hujer, Jose R Mediavilla, Claudia Manca, Thuy Tien T Tran, T Nicholas Domitrovic, Paul G Higgins, Harald Seifert, Barry N Kreiswirth, Robin Patel, Michael R Jacobs, Liang Chen, Rangarajan Sampath, Thomas Hall, Christine Marzan, Vance G Fowler, Henry F Chambers, Robert A Bonomo
No abstract text is available yet for this article.
June 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28528212/targeted-co-delivery-of-polypyrrole-and-rapamycin-by-trastuzumab-conjugated-liposomes-for-combined-chemo-photothermal-therapy
#19
Hanh Thuy Nguyen, Tuan Hiep Tran, Raj Kumar Thapa, Cao Dai Phung, Beom Soo Shin, Jee-Heon Jeong, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Trastuzumab is a therapeutic monoclonal antibody that selectively recognizes HER2/neu receptor for targeting breast cancers. In this study, we aimed to present a strategy to combine chemo and phototherapy and targeted delivery via monoclonal antibody for enhanced anticancer effects. We co-loaded a chemotherapeutic agent, rapamycin, and a photosensitizer, polypyrrole, in trastuzumab-conjugated liposomes (LRPmAb) for combined chemo-photothermal therapy. LRPmAb had small size (172.2±9.6nm), narrow distribution, and negative ζ-potential (-12...
May 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28497252/gallbladder-cancer-presenting-with-jaundice-uniformly-fatal-or-still-potentially-curable
#20
Thuy B Tran, Jeffrey A Norton, Cecilia G Ethun, Timothy M Pawlik, Stefan Buettner, Carl Schmidt, Eliza W Beal, William G Hawkins, Ryan C Fields, Bradley A Krasnick, Sharon M Weber, Ahmed Salem, Robert C G Martin, Charles R Scoggins, Perry Shen, Harveshp D Mogal, Kamran Idrees, Chelsea A Isom, Ioannis Hatzaras, Rivfka Shenoy, Shishir K Maithel, George A Poultsides
BACKGROUND: Jaundice as a presenting symptom of gallbladder cancer has traditionally been considered to be a sign of advanced disease, inoperability, and poor outcome. However, recent studies have demonstrated that a small subset of these patients can undergo resection with curative intent. METHODS: Patients with gallbladder cancer managed surgically from 2000 to 2014 in 10 US academic institutions were stratified based on the presence of jaundice at presentation (defined as bilirubin ≥4 mg/ml or requiring preoperative biliary drainage)...
August 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
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