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Epidermial growth factor receptor

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https://www.readbyqxmd.com/read/28628612/novel-interplay-between-jnk-and-egfr-signaling-in-drosophila-dorsal-closure
#1
Tatyana Kushnir, Sharon Mezuman, Shaked Bar-Cohen, Rotem Lange, Ze'ev Paroush, Aharon Helman
Dorsal closure (DC) is a developmental process in which two contralateral epithelial sheets migrate to seal a large hole in the dorsal ectoderm of the Drosophila embryo. Two signaling pathways act sequentially to orchestrate this dynamic morphogenetic process. First, c-Jun N-terminal kinase (JNK) signaling activity in the dorsal-most leading edge (LE) cells of the epidermis induces expression of decapentaplegic (dpp). Second, Dpp, a secreted TGF-β homolog, triggers cell shape changes in the adjacent, ventrally located lateral epidermis, that guide the morphogenetic movements and cell migration mandatory for DC...
June 19, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28514643/yorkie-regulates-epidermal-wound-healing-in-drosophila-larvae-independently-of-cell-proliferation-and-apoptosis
#2
Chang-Ru Tsai, Aimee E Anderson, Sirisha Burra, Juyeon Jo, Michael J Galko
Yorkie (Yki), the transcriptional co-activator of the Hippo signaling pathway, has well-characterized roles in balancing apoptosis and cell division during organ growth control. Yki is also required in diverse tissue regenerative contexts. In most cases this requirement reflects its well-characterized roles in balancing apoptosis and cell division. Whether Yki has repair functions outside of the control of cell proliferation, death, and growth is not clear. Here we show that Yki and Scalloped (Sd) are required for epidermal wound closure in the Drosophila larval epidermis...
May 14, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28418591/a-hypomorphic-egfr-allele-does-not-ameliorate-the-palmoplantar-keratoderma-caused-by-slurp1-deficiency
#3
Christopher M Allan, Deanna Tran, Yiping Tu, Patrick J Heizer, Lorraine C Young, Loren G Fong, Anne P Beigneux, Stephen G Young
Mutations in SLURP1, a secreted protein of keratinocytes, cause a palmoplantar keratoderma (PPK) known as mal de Meleda. Slurp1 deficiency in mice faithfully recapitulates the human disease, with increased keratinocyte proliferation and thickening of the epidermis on the volar surface of the paws. There has long been speculation that SLURP1 serves as a ligand for a receptor that regulates keratinocyte growth and differentiation. We were intrigued that mutations leading to increased signaling through the epidermal growth factor receptor (EGFR) cause PPK...
April 18, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28349651/dermasence-refining-gel-modulates-pathogenetic-factors-of-rosacea-in-vitro
#4
C Borelli, B Becker, S Thude, B Fehrenbacher, D Isermann
BACKGROUND: Over the counter cosmetics sold for local treatment of slight to moderate rosacea often state the claim of actively modulating rosacea pathogenesis. Factors involved in the pathogenesis of this common yet complex skin disorder include kallikrein-related peptidase 5 (KLK5), LL-37, as well as protease-activated receptor 2 (PAR2) and vascular endothelial growth factor (VEGF). OBJECTIVE: The objective was to prove the modulating effect of the cosmetic skin care agent Dermasence Refining Gel (DRG) on factors involved in rosacea pathogenesis...
March 27, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28094870/igf1r-signalling-acts-on-the-anagen-to-catagen-transition-in-the-hair-cycle
#5
Mathieu Castela, Fabien Linay, Edwige Roy, Philippe Moguelet, Jie Xu, Martin Holzenberger, Kiarash Khosrotehrani, Selim Aractingi
Insulin-like growth factor 1 (Igf1) is important for skin development and homoeostasis. However, overexpression and inactivation studies have produced variable findings regarding its role in hair follicle (HF) biology. Here, we studied a conditional and inducible knockout of the Igf1 receptor (Igf1r) in keratin 15-expressing bulge cells. Deletion of Igf1r after the development of the skin appendages in K15-Igf1r(KO) mice showed no abnormalities in epidermal homoeostasis. Numbers of bulge cells were lower in K15-Igf1r(KO) mice than in controls, without consequences on wound healing, at least in young mice...
January 17, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28018369/insights-into-the-role-of-the-berry-specific-ethylene-responsive-factor-vvierf045
#6
Carmen Leida, Antonio Dal Rì, Lorenza Dalla Costa, Maria D Gómez, Valerio Pompili, Paolo Sonego, Kristof Engelen, Domenico Masuero, Gabino Ríos, Claudio Moser
During grape ripening, numerous transcriptional and metabolic changes are required in order to obtain colored, sweet, and flavored berries. There is evidence that ethylene, together with other signals, plays an important role in triggering the onset of ripening. Here, we report the functional characterization of a berry-specific Ethylene Responsive Factor (ERF), VviERF045, which is induced just before véraison and peaks at ripening. Phylogenetic analysis revealed it is close to the SHINE clade of ERFs, factors involved in the regulation of wax biosynthesis and cuticle morphology...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27979585/the-differential-expression-of-protease-activated-receptors-contributes-to-functional-differences-between-dark-and-fair-keratinocytes
#7
Meilang Xue, Haiyan Lin, Ruilong Zhao, Hai Po Helena Liang, Christopher Jackson
BACKGROUND: Dark skin has different properties in comparison to fair skin. Melanocytes have been shown to partly contribute to these differences, however, the involvement of keratinocytes from dark or fair skin is not well demonstrated. OBJECTIVES: This study investigated the proliferation and barrier function of dark keratinocytes (DK) and fair keratinocytes (FK), and the role of protease activated receptor (PAR)1 and PAR2. METHODS: DK and FK were isolated from human neonatal foreskins...
December 5, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27931797/erbb2-is-essential-for-the-growth-of-chemically-induced-skin-tumors-in-mice
#8
Maik Dahlhoff, Sukalp Muzumdar, Matthias Schäfer, Marlon R Schneider
Although the epidermal growth factor receptor has established roles in skin carcinogenesis, inflammation, and wound healing, the functions of the structurally related receptor ERBB2 in this tissue remain poorly explored. To assess the functions of ERBB2 in skin homeostasis, tumorigenesis, and wound healing, we employed keratin 5-directed, cre recombinase-mediated targeting of Erbb2 alleles in mice. Erbb2(del) mice, lacking ERBB2 specifically in keratinocytes, showed no noticeable spontaneous skin abnormalities...
December 6, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27892604/interleukin-il-6-modulates-transforming-growth-factor-%C3%AE-receptor-i-and-ii-tgf-%C3%AE-ri-and-ii-function-in-epidermal-keratinocytes
#9
Lerin R Luckett-Chastain, Mackenzie L Cottrell, Bethany M Kawar, Michael A Ihnat, Randle M Gallucci
It been shown that IL-6 modulates TGF-β1 expression in fibroblasts, however, what role IL-6 plays concerning TGF-βR expression and function in skin is unknown. Therefore, the aim of this study was to investigate the mechanism by which IL-6 might modulates TGF-β receptors in skin. Skin from WT, IL-6 over-expressing mice and IL-6 treated keratinocyte cultures was analysed for TGF-βRI and TGF-βRII expression via histology, PCR and flow cytometry. Receptor function was assessed by cell migration, bromodeoxyuridine (BrdU) proliferation assays, and Smad7 expression and Smad2/3 phosphorylation...
November 28, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27866969/overexpression-of-cd109-in-the-epidermis-differentially-regulates-alk1-versus-alk5-signaling-and-modulates-extracellular-matrix-synthesis-in-the-skin
#10
Joshua Vorstenbosch, Christopher M Nguyen, Shufeng Zhou, You Jung Seo, Aya Siblini, Kenneth W Finnson, Albane A Bizet, Simon D Tran, Anie Philip
Transforming growth factor-β (TGF-β) is a multifunctional growth factor involved in many physiological processes including wound healing and inflammation. Excessive TGF-β signaling in the skin has been implicated in fibrotic skin disorders such as keloids and scleroderma. We previously identified CD109 as a TGF-β co-receptor and inhibitor of TGF-β signaling and have shown that transgenic mice overexpressing CD109 in the epidermis display decreased scarring. In certain cell types, in addition to the canonical type I receptor, ALK5, which activates Smad2/3, TGF-β can signal through another type I receptor, ALK1, which activates Smad1/5...
March 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27831556/epidermal-specific-deletion-of-cd44-reveals-a-function-in-keratinocytes-in-response-to-mechanical-stress
#11
M Shatirishvili, A S Burk, C M Franz, G Pace, T Kastilan, K Breuhahn, E Hinterseer, A Dierich, L Bakiri, E F Wagner, H Ponta, T N Hartmann, M Tanaka, V Orian-Rousseau
CD44, a large family of transmembrane glycoproteins, plays decisive roles in physiological and pathological conditions. CD44 isoforms are involved in several signaling pathways essential for life such as growth factor-induced signaling by EGF, HGF or VEGF. CD44 is also the main hyaluronan (HA) receptor and as such is involved in HA-dependent processes. To allow a genetic dissection of CD44 functions in homeostasis and disease, we generated a Cd44 floxed allele allowing tissue- and time-specific inactivation of all CD44 isoforms in vivo...
November 10, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27489428/expression-of-epidermal-c-kit-of-vitiligo-lesions-is-related-to-responses-to-excimer-laser
#12
Oun Jae Park, Ji Su Han, Sang Hyung Lee, Chan-Sik Park, Chong Hyun Won, Mi Woo Lee, Jee Ho Choi, Sung Eun Chang
BACKGROUND: The survival and growth of melanocytes are controlled by the binding of stem cell factor to its cell surface receptor c-kit+ (CD117). We have observed that c-kit+ melanocytes existed in some lesions of vitiligo, while Melan A+ cells were absent. OBJECTIVE: To verify possible relation between c-kit+ expression and treatment response in non-segmental vitiligo lesions. METHODS: Skin biopsies were done from the center of the 47 lesions from the 47 patients with non-segmental vitiligo...
August 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27442430/activation-of-molecular-signatures-for-antimicrobial-and-innate-defense-responses-in-skin-with-transglutaminase-1-deficiency
#13
Takashi Haneda, Yasutomo Imai, Ryosuke Uchiyama, Orie Jitsukawa, Kiyofumi Yamanishi
Mutations of the transglutaminase 1 gene (TGM1) are a major cause of autosomal recessive congenital ichthyoses (ARCIs) that are associated with defects in skin barrier structure and function. However, the molecular processes induced by the transglutaminase 1 deficiency are not fully understood. The aim of the present study was to uncover those processes by analysis of cutaneous molecular signatures. Gene expression profiles of wild-type and Tgm1-/-epidermis were assessed using microarrays. Gene ontology analysis of the data showed that genes for innate defense responses were up-regulated in Tgm1-/-epidermis...
2016: PloS One
https://www.readbyqxmd.com/read/27426071/-advances-in-the-research-of-biological-characters-and-pathophysiological-effects-of-dendritic-epidermal-t-lymphocytes
#14
Y S Li, W F He, J Wu
The maturation of dendritic epidermal T lymphocytes (DETCs) in thymus needs ligand-mediated positive selection, and positive selection together with V3γ(+) γδT lymphocytes intrinsic program features order DETCs to specifically migrate to epidermis. Positive selection promotes DETCs to express CD122, which is vital for DETCs to survive and proliferate in skin. DETCs possess memory-like phenotype and are able to rapidly respond to danger signals when they move out from thymus. NKG2D, junctional adhesion molecule-like protein and 2B4 are demonstrated to participate in DETCs activation, except for ligands of T lymphocytes receptor...
January 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27371823/tissue-injury-and-repair-following-cutaneous-exposure-of-mice-to-sulfur-mustard
#15
Laurie B Joseph, Gabriella M Composto, Diane E Heck
In mouse skin, sulfur mustard (SM) is a potent vesicant, damaging both the epidermis and the dermis. The extent of wounding is dependent on the dose of SM and the duration of exposure. Initial responses include erythema, pruritus, edema, and xerosis; this is followed by an accumulation of inflammatory leukocytes in the tissue, activation of mast cells, and the release of mediators, including proinflammatory cytokines and bioactive lipids. These proinflammatory mediators contribute to damaging the epidermis, hair follicles, and sebaceous glands and to disruption of the epidermal basement membrane...
August 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27351421/integrin-mediated-regulation-of-epidermal-wound-functions
#16
REVIEW
C Michael DiPersio, Rui Zheng, James Kenney, Livingston Van De Water
During cutaneous wound healing, keratinocyte proliferation and migration are critical for re-epithelialization. In addition the epidermis secretes growth factors, cytokines, proteases, and matricellular proteins into the wound microenvironment that modify the extracellular matrix and stimulate other wound cells that control the inflammatory response, promote angiogenesis and facilitate tissue contraction and remodeling. Wound keratinocytes express at least seven different integrins-the major cell adhesion receptors for the extracellular matrix-that collectively control essential cell-autonomous functions to ensure proper re-epithelialization, including migration, proliferation, survival and basement membrane assembly...
September 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27249340/direct-interaction-of-avermectin-with-epidermal-growth-factor-receptor-mediates-the-penetration-resistance-in-drosophila-larvae
#17
Li-Ping Chen, Pan Wang, Ying-Jian Sun, Yi-Jun Wu
With the widespread use of avermectins (AVMs) for managing parasitic and agricultural pests, the resistance of worms and insects to AVMs has emerged as a serious threat to human health and agriculture worldwide. The reduced penetration of AVMs is one of the main reasons for the development of the resistance to the chemicals. However, the detailed molecular mechanisms remain elusive. Here, we use the larvae of Drosophila melanogaster as the model organism to explore the molecular mechanisms underlying the development of penetration resistance to AVMs...
April 2016: Open Biology
https://www.readbyqxmd.com/read/27123054/identification-of-potential-therapeutic-target-genes-and-mechanisms-in-head-and-neck-squamous-cell-carcinoma-by-bioinformatics-analysis
#18
Jing Kuang, Mei Zhao, Huilian Li, Wei Dang, Wei Li
The present study aimed to identify the potential target genes and underlying molecular mechanisms involved in head and neck squamous cell carcinoma (HNSCC) by bioinformatics analysis. Microarray data of a Gene Expression Omnibus series GSE6631 was downloaded from the Gene Expression Omnibus database, which was generated from paired samples of HNSCC and normal tissue from 22 patients, and was used to identify differentially expressed genes (DEGs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed to investigate the functions of the identified DEGs...
May 2016: Oncology Letters
https://www.readbyqxmd.com/read/27073643/concomitant-cetuximab-and-radiation-therapy-a-possible-promising-strategy-for-locally-advanced-inoperable-non-melanoma-skin-carcinomas
#19
Giuseppina Della Vittoria Scarpati, Francesco Perri, Salvatore Pisconti, Giuseppe Costa, Filippo Ricciardiello, Salvatore Del Prete, Alberto Napolitano, Marco Carraturo, Salvatore Mazzone, Raffaele Addeo
Non-melanoma skin cancers (NMSCs) include a heterogeneous group of malignancies arising from the epidermis, comprising squamous cell carcinoma (SCC), basal cell carcinoma (BCC), Merkel cell carcinoma and more rare entities, including malignant pilomatrixoma and sebaceous gland tumours. The treatment of early disease depends primarily on surgery. In addition, certain patients present with extensive local invasion or metastasis, which renders these tumours surgically unresectable. Improving the outcome of radiotherapy through the use of concurrent systemic therapy has been demonstrated in several locally advanced cancer-treatment paradigms...
April 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27011245/-tetraspanins-in-cutaneous-physiopathology
#20
REVIEW
Ingrid Masse, Gweltaz Agaësse, Odile Berthier-Vergnes
Tetraspanins are transmembrane proteins that interact laterally with each other and with different partners such as integrins, immunoglobulin (Ig)-domain-containing proteins, growth factors and cytokine receptors. Such tetraspanin-partner complexes help to organize dynamic membrane networks called "tetraspanin web", which trigger different signalling pathways. Despite the fact that tetraspanins seem abundantly and widely expressed, their function remained unclear. However, it is well established that they control fundamental cellular processes including cell survival, adhesion, migration, invasion or viral infection, but the underlying molecular mechanisms are not well elucidated...
March 2016: Médecine Sciences: M/S
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