Liron Marnin, Haikel N Bogale, Hanna J Laukaitis-Yousey, Luisa M Valencia, Agustin Rolandelli, Anya J O'Neal, Camila Rodrigues Ferraz, Axel D Schmitter-Sánchez, Emily Bencosme Cuevas, Thu-Thuy Nguyen, Brenda Leal-Galvan, David M Rickert, Vincent M Bruno, M Tays Mendes, Sourabh Samaddar, L Rainer Butler, Nisha Singh, Francy E Cabrera Paz, Jonathan D Oliver, Julie M Jameson, Ulrike G Munderloh, Adela S Oliva Chávez, Albert Mulenga, Sangbum Park, David Serre, Joao H F Pedra
Hematophagous ectoparasites, such as ticks, rely on impaired wound healing for skin attachment and blood feeding. Wound healing has been extensively studied through the lens of inflammatory disorders and cancer, but limited attention has been given to arthropod-borne diseases. Here, we used orthogonal approaches combining single-cell RNA sequencing (scRNAseq), flow cytometry, murine genetics, and intravital microscopy to demonstrate how tick extracellular vesicles (EVs) disrupt networks involved in tissue repair...
November 10, 2023: bioRxiv