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https://www.readbyqxmd.com/read/29337962/the-relationship-between-right-sided-tumour-location-tumour-microenvironment-systemic-inflammation-adjuvant-therapy-and-survival-in-patients-undergoing-surgery-for-colon-and-rectal-cancer
#1
Meera Patel, Stephen T McSorley, James H Park, Campbell S D Roxburgh, Joann Edwards, Paul G Horgan, Donald C McMillan
BACKGROUND: There has been an increasing interest in the role of tumour location in the treatment and prognosis of patients with colorectal cancer (CRC), specifically in the adjuvant setting. Together with genomic data, this has led to the proposal that right-sided and left-sided tumours should be considered as distinct biological and clinical entities. The aim of the present study was to examine the relationship between tumour location, tumour microenvironment, systemic inflammatory response (SIR), adjuvant chemotherapy and survival in patients undergoing potentially curative surgery for stage I-III colon and rectal cancer...
January 16, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29290999/impact-of-neoadjuvant-and-adjuvant-radiotherapy-on-disease-specific-survival-in-patients-with-stages-ii-iv-rectal-cancer
#2
Yinying Wu, Haiyang Liu, Xianglin L Du, Fan Wang, Jing Zhang, Xiaohai Cui, Enxiao Li, Jin Yang, Min Yi, Yunfeng Zhang
Objectives: The purposes of this study were to determine whether neoadjuvant or adjuvant radiotherapy affected disease-specific survival (DSS) in patients with rectal cancer and whether stratification by tumor stage affected the results. Results: 55.5% patients had neoadjuvant-radiotherapy (NRT), and 18.3% patients had adjuvant- radiotherapy (ART). Multivariable models showed that treatment type was independently associated with DSS. Patients with stages III/IV tumors who received ART plus chemotherapy had significantly worse DSS than did those who received NRT plus chemotherapy (NCRT) (P = 0...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29288190/can-we-save-the-rectum-by-watchful-waiting-or-transanal-microsurgery-following-chemo-radiotherapy-versus-total-mesorectal-excision-for-early-rectal-cancer-star-trec-study-protocol-for-a-multicentre-randomised-feasibility-study
#3
Anouk J M Rombouts, Issam Al-Najami, Natalie L Abbott, Ane Appelt, Gunnar Baatrup, Simon Bach, Aneel Bhangu, Karen-Lise Garm Spindler, Richard Gray, Kelly Handley, Manjinder Kaur, Ellen Kerkhof, Camilla Jensenius Kronborg, Laura Magill, Corrie A M Marijnen, Iris D Nagtegaal, Lars Nyvang, Femke P Peters, Per Pfeiffer, Cornelis Punt, Philip Quirke, David Sebag-Montefiore, Mark Teo, Nick West, Johannes H W de Wilt
INTRODUCTION: Total mesorectal excision (TME) is the highly effective standard treatment for rectal cancer but is associated with significant morbidity and may be overtreatment for low-risk cancers. This study is designed to determine the feasibility of international recruitment in a study comparing organ-saving approaches versus standard TME surgery. METHODS AND ANALYSIS: STAR-TREC trial is a multicentre international randomised, three-arm parallel, phase II feasibility study in patients with biopsy-proven adenocarcinoma of the rectum...
December 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/29277386/outcomes-of-persistent-lymph-node-involvement-after-neoadjuvant-therapy-for-stage-iii-rectal-cancer
#4
Anne M Dinaux, Lieve Leijssen, Liliana G Bordeianou, Hiroko Kunitake, Ramzi Amri, David L Berger
INTRODUCTION: Lymph node involvement is a well-known predictor of recurrent rectal cancer in patient who did not undergo neoadjuvant therapy patients. The role of persistent lymph node disease after neoadjuvant treatment, however, is debatable. This study compares outcomes of patients with clinical, stage III rectal cancer who had nodal disease on surgical pathology after neoadjuvant treatment to patients with negative nodes. METHODS: We reviewed retrospectively a consecutive cohort of all clinical, American Joint Committee on Cancer stage III rectal cancer patients who received neoadjuvant chemoradiotherapy and had an R0 resection at the Massachusetts General Hospital between 2004 and 2015...
December 22, 2017: Surgery
https://www.readbyqxmd.com/read/29275667/trends-in-presentation-treatment-and-survival-of-1777-patients-with-colorectal-cancer-over-a-decade-a-biobank-study
#5
Eetu Heervä, Anu Carpelan, Samu Kurki, Jari Sundström, Heikki Huhtinen, Arto Rantala, Annika Ålgars, Raija Ristamäki, Olli Carpén, Heikki Minn
BACKGROUND: Most survival data in colorectal cancer (CRC) is derived from clinical trials or register-based studies. Hospital Biobanks, linked with hospital electronic records, could serve as a data-gathering method based on consecutively collected tumor samples. The aim of this Biobank study was to analyze survival of colorectal patients diagnosed and treated in a single-center university hospital over a period of 12 years, and to evaluate factors contributing to outcome. MATERIAL AND METHODS: A total of 1777 patients with CRC treated during 2001-2012 were identified from the Auria Biobank, Turku, Finland...
December 23, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29273363/lmr-predicts-outcome-in-patients-after-preoperative-chemoradiotherapy-for-stage-ii-iii-rectal-cancer
#6
Shinya Abe, Kazushige Kawai, Hiroaki Nozawa, Keisuke Hata, Tomomichi Kiyomatsu, Teppei Morikawa, Toshiaki Watanabe
BACKGROUND: Recently, lymphocyte-to-monocyte ratio (LMR) has attracted attention as a new marker of the chronic systemic inflammatory response and has been associated with patient prognosis in those who underwent chemoradiotherapy (CRT) for several solid cancers. This study aimed to evaluate the association between LMR and the prognosis of patients with rectal cancer. METHODS: A total of 183 stage II-III rectal cancer patients who underwent preoperative CRT followed by surgical R0 resection were retrospectively reviewed...
February 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29233486/cetuximab-combined-with-induction-oxaliplatin-and-capecitabine-followed-by-neoadjuvant-chemoradiation-for-locally-advanced-rectal-cancer-swog-0713
#7
Cynthia Gail Leichman, Shannon L McDonough, Stephen R Smalley, Kevin G Billingsley, Heinz-Josef Lenz, Matthew A Beldner, Aram F Hezel, Mario R Velasco, Katherine A Guthrie, Charles D Blanke, Howard S Hochster
BACKGROUND: Neoadjuvant chemoradiation (NCRT) is standard treatment for locally advanced rectal cancer. Pathologic complete response (pCR) has associated with improved survival. In modern phase III trials of NCRT, pCR ranges from 10% to 20%. Cetuximab improves response in KRAS (KRAS proto-oncogene) wild type (wt) metastatic colorectal cancer. S0713 was designed to assess improvement in pCR with additional use of cetuximab with induction chemotherapy and NCRT for locally advanced, KRAS-wt rectal cancer...
October 24, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29229129/hospital-safety-net-burden-does-not-predict-differences-in-rectal-cancer-treatment-and-outcomes
#8
Richard S Hoehn, Derek E Go, Dennis J Hanseman, Shimul A Shah, Ian M Paquette
BACKGROUND: Safety-net hospitals have been shown to have inferior short-term surgical outcomes. The aim of this study was to compare rectal cancer management and survival across hospitals stratified by payer mix. MATERIALS AND METHODS: Rectal cancer patients (n = 296,068) were identified using the 1998-2010 National Cancer Data Base. Hospitals were grouped into safety-net burden categories, according to the proportion of patients with Medicaid or no health insurance, as follows: low-, medium-, and high-burden hospitals (HBHs)...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29223019/are-pathological-high-risk-features-in-locally-advanced-rectal-cancer-a-useful-selection-tool-for-adjuvant-chemotherapy
#9
Marloes Swets, Peter J K Kuppen, Erik J Blok, Hans Gelderblom, Cornelis J H van de Velde, Iris D Nagtegaal
BACKGROUND: Several histological high-risk factors are used as an indication for adjuvant therapy in stage II colon cancer. Those and other factors, including lymphatic invasion, perineural invasion (PNI), venous invasion and tumour budding are associated with decreased outcome. In this study, we evaluated the prognostic and predictive values of these biomarkers in a cohort of rectal cancer patients. MATERIALS AND METHODS: The trial-based cohort consisted of 221npTNM stage II-III rectal cancer patients, included in the PROCTOR/SCRIPT trial, a multicentre randomised phase III trial...
January 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29208881/clinicopathological-assessment-of-colorectal-carcinoma-in-mymensingh-medical-college-hospital-bangladesh
#10
M M Mahamud, F Wahed, J Ferdous, M K Khan
Colorectal carcinoma (CRC) is the third most commonly diagnosed cancer and the third leading cause of cancer death in both men and women in the US. It is mainly a disease of the developed countries with a western culture, yet the disease is not uncommon in developing countries. There is substantial geographical variation in the incidence and demographic characteristics of the disease. Variations are also observed in the risk factors, mode of presentation, sub site distribution and stage of the disease at presentation...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29208050/robotic-assisted-total-mesorectal-excision-with-the-single-docking-technique-for-patients-with-rectal-cancer
#11
Ching-Wen Huang, Hsiang-Lin Tsai, Yung-Sung Yeh, Wei-Chih Su, Ming-Yii Huang, Chun-Ming Huang, Yu-Tang Chang, Jaw-Yuan Wang
BACKGROUND: The robotic system has advantages of high-definition three-dimensional vision and articular instruments with high dexterity, allowing more precise dissection in the deep and narrow pelvic cavity. METHODS: We enrolled 95 patients with stage I-III rectal cancer (adenocarcinoma) who underwent totally robotic-assisted total mesorectal excision (TME) with single-docking technique at a single institution between September 2013 and December 2016. RESULTS: Of the 95 patients, 48 (50...
December 5, 2017: BMC Surgery
https://www.readbyqxmd.com/read/29206996/tumor-regression-grading-after-preoperative-chemoradiotherapy-as-a-prognostic-factor-and-individual-level-surrogate-for-disease-free-survival-in-rectal-cancer
#12
RANDOMIZED CONTROLLED TRIAL
Emmanouil Fokas, Philipp Ströbel, Rainer Fietkau, Michael Ghadimi, Torsten Liersch, Gerhard G Grabenbauer, Arndt Hartmann, Marco Kaufmann, Rolf Sauer, Ullrich Graeven, Hans Hoffmanns, Hans-Rudolf Raab, Torsten Hothorn, Christian Wittekind, Claus Rödel
Background: We investigated tumor regression grading (TRG) as a prognostic marker and individual-level surrogate for disease-free survival (DFS) in patients with rectal carcinoma treated within the Chirurgische Arbeitsgemeinschaft fur Onkologie/Arbeitsgemeinschaft Radiologische Onkologie/Arbeitsgemeinschaft Internistische Onkologie (CAO/ARO/AIO)-04 randomized trial. Methods: TRG was recorded prospectively using the Dworak classification in 1179 patients after preoperative fluorouracil-based chemoradiotherapy (CRT) with or without oxaliplatin...
December 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29174165/the-negative-impact-of-understaging-rectal-cancer-patients
#13
A M Dinaux, L G J Leijssen, L G Bordeianou, H Kunitake, R Amri, D L Berger
BACKGROUND: Neo-adjuvant chemoradiation followed by surgery and adjuvant therapy is standard treatment of clinical node positive rectal cancer. Understaging leads to delay in treatment with possible detrimental results. This study analyses effects of understaging stage III rectal cancer on long-term outcomes. METHODS: A consecutive series of patients, operated on in MGH between 2004 and 2015 was included. Outcomes of non-neoadjuvantly treated clinical stage I patients who turned out to have pathological stage III disease and neoadjuvantly treated clinical stage III patients were retrospectively reviewed...
November 8, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29165692/prognostic-value-of-clinical-vs-pathologic-stage-in-rectal-cancer-patients-receiving-neoadjuvant-therapy
#14
Daniel Delitto, Thomas J George, Tyler J Loftus, Peihua Qiu, George J Chang, Carmen J Allegra, William A Hall, Steven J Hughes, Sanda A Tan, Christiana M Shaw, Atif Iqbal
Background: Neoadjuvant chemoradiation is currently standard of care in stage II-III rectal cancer, resulting in tumor downstaging for patients with treatment-responsive disease. However, the prognosis of the downstaged patient remains controversial. This work critically analyzes the relative contribution of pre- and post-therapy staging to the anticipated survival of downstaged patients. Methods: The National Cancer Database (NCDB) was queried for patients with rectal cancer treated with transabdominal resection between 2004 and 2014...
November 20, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29163812/identification-of-metastasis-associated-micrornas-in-serum-from-rectal-cancer-patients
#15
Robin Mjelle, Kjersti Sellæg, Pål Sætrom, Liv Thommesen, Wenche Sjursen, Eva Hofsli
MicroRNAs (miRNAs) are promising prognostic and diagnostic biomarkers due to their high stability in blood. Here we investigate the expression of miRNAs and other noncoding (nc) RNAs in serum of rectal cancer patients. Serum from 96 rectal cancer patients was profiled using small RNA sequencing and expression of small RNAs was correlated with the clinicopathological characteristics of the patients. Multiple classes of RNAs were detected, including miRNAs and fragments of tRNAs, snoRNAs, long ncRNAs, and other classes of RNAs...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29159744/treatment-and-outcome-of-synchronous-colorectal-carcinomas-a-nationwide-study
#16
A C R K Bos, R A Matthijsen, F N van Erning, M G H van Oijen, H J T Rutten, V E P P Lemmens
BACKGROUND: Synchronous colorectal carcinomas (CRC) occur in 1-8% of patients diagnosed with CRC. This study evaluated treatment patterns and patient outcomes in synchronous CRCs compared with solitary CRC patients. METHODS: All patients diagnosed with primary CRC between 2008 and 2013, who underwent elective surgery, were selected from the Netherlands Cancer Registry. Using multivariable regressions, the effects of synchronous CRC were assessed for both short-term outcomes (prolonged postoperative hospital admission, anastomotic leakage, postoperative 30-day mortality, administration of neoadjuvant or adjuvant treatment), and 5-year relative survival (RS)...
November 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29158782/a-phase-ii-trial-of-preoperative-concurrent-chemotherapy-and-dose-escalated-intensity-modulated-radiotherapy-imrt-for-locally-advanced-rectal-cancer
#17
Jeremy Tey, Cheng Nang Leong, Wai Kit Cheong, Tay Guan Sze, Wei Peng Yong, Ivan Weng Keong Tham, Khai Mun Lee
Objectives: To determine the pathological response rates and toxicity and in patients with locally advanced rectal cancer treated with concurrent capecitabine and dose escalated intensity modulated radiotherapy (IMRT) Methods: Patients with stage II or III adenocarcinoma of the rectum were treated with preoperative concurrent capecitabine and IMRT. Dose of capecitabine was 825mg/m(2), 5 days a week for 5 weeks. IMRT was used to deliver a dose of 45Gy in 25 fractions (1.8Gy per fraction daily, 5 days a week over 5 weeks) to the regional lymphatics and areas at risk of harbouring microscopic disease...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29112561/nodal-disease-in-rectal-cancer-patients-with-complete-tumor-response-after-neoadjuvant-chemoradiation-danger-below-calm-waters
#18
Rebeccah B Baucom, Lillias H Maguire, Sandra L Kavalukas, Timothy M Geiger, Molly M Ford, Roberta L Muldoon, M Benjamin Hopkins, Alexander T Hawkins
BACKGROUND: A subset of patients with rectal cancer who undergo neoadjuvant chemoradiation therapy will develop a complete pathologic tumor response. Complete nodal response is not universal in these patients and is difficult to assess clinically. Quantifying the risk of nodal disease would allow for targeted therapy with either radical resection or "watchful waiting." OBJECTIVE: This study aimed to identify risk factors for residual nodal disease in ypT0 rectal adenocarcinoma...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29112560/is-the-distance-worth-it-patients-with-rectal-cancer-traveling-to-high-volume-centers-experience-improved-outcomes
#19
Zhaomin Xu, Adan Z Becerra, Carla F Justiniano, Courtney I Boodry, Christopher T Aquina, Alex A Swanger, Larissa K Temple, Fergal J Fleming
BACKGROUND: It is unclear whether traveling long distances to high-volume centers would compensate for travel burden among patients undergoing rectal cancer resection. OBJECTIVE: The purpose of this study was to determine whether operative volume outweighs the advantages of being treated locally by comparing the outcomes of patients with rectal cancer treated at local, low-volume centers versus far, high-volume centers. DESIGN: This was a population-based study...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29110585/cell-free-dna-levels-and-correlation-to-stage-and-outcome-following-treatment-of-locally-advanced-rectal-cancer
#20
Anders Kindberg Boysen, Yvonne Wettergren, Boe Sandahl Sorensen, Helena Taflin, Bengt Gustavson, Karen-Lise Garm Spindler
Accurate staging of rectal cancer remains essential for optimal patient selection for combined modality treatment, including radiotherapy, chemotherapy and surgery. We aimed at examining the correlation of cell free DNA with the pathologic stage and subsequent risk of recurrence for patients with locally advanced rectal cancer undergoing preoperative chemoradiation. We examined 75 patients with locally advanced rectal cancer receiving preoperative chemoradiation. Blood samples for translational use were drawn prior to rectal surgery...
November 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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