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III stage rectal cancer

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https://www.readbyqxmd.com/read/28087988/cpg-island-methylator-phenotype-is-an-independent-predictor-of-survival-after-curative-resection-for-colorectal-cancer-a-prospective-cohort-study
#1
Chang Hyun Kim, Jung Wook Huh, Hyeong Rok Kim, Young Jin Kim
BACKGROUND AND AIMS: The CpG island methylator phenotype (CIMP) is found in approximately 30% of colorectal cancer (CRC) cases. However, the role of CIMP status in predicting oncologic outcomes in curatively resected CRC is still unclear. STUDY: Between January 2006 and December 2006, we retrospectively reviewed 157 consecutive patients who underwent curative surgery for CRC. Prognostic significance of CIMP status was evaluated using reverse transcriptase-polymerase chain reaction...
January 14, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28047202/su-f-t-358-is-auto-planning-useful-for-volumetric-modulated-arc-therapy-planning-in-rectal-cancer-radiotherapy
#2
K Li, X Chang, J Wang, P Hu, W Hu
PURPOSE: To evaluate whether Auto-Planning based volumetric-modulated radiotherapy (auto-VMAT) can reduce manual interaction time during treatment planning and improve plan quality for rectal cancer radiotherapy. METHODS: Ten rectal cancer patients (stage II and III) after radical resection using Dixon surgery were enrolled. All patients were treated with VMAT technique. The manual VMAT plans (man-VMAT) were designed in the Pinnacle treatment planning system (Version 9...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044949/sphincter-sparing-surgery-in-patients-with-mid-and-low-rectal-cancer-risk-factors-for-local-recurrence-and-anastomotic-leakage
#3
Denis Aslan, Florin Grama, Daniel Cristian, Adrian Bordea, Traean Burcoş
: Background: Rectal cancer is a major health problem. The current treatment of distal rectal cancer involves a multimodality approach aimed at achieving an optimal oncologic control and an increased quality of life. PURPOSE: The purpose of this article is to identify the risk factors for local recurrence and anastomotic leakage after sphincter-sparing surgery for low and mid rectal cancer. Material and Methods: We prospectively analyzed a group of 38 patients with low and middle rectal cancer who underwent sphincter-sparing surgery...
November 2016: Chirurgia
https://www.readbyqxmd.com/read/28035252/signet-ring-colorectal-carcinoma-do-we-need-to-improve-the-treatment-algorithm
#4
Anup Sunil Tamhankar, Parag Ingle, Reena Engineer, Munita Bal, Vikas Ostwal, Avanish Saklani
AIM: To elaborate about this peculiar variant from a tertiary cancer center from India. METHODS: It's a retrospective study (2011-2014) of all patients diagnosed with signet ring colo-rectal cancer (SRCC). Various clinico-pathological variables were studied. RESULTS: One hundred and seventy consecutive patients with SRCC were diagnosed (11.4% of all colorectal cancers). Median Age of the cohort was 41 years. Most common location was recto-sigmoid area (54...
December 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28011887/sweet-syndrome-a-painful-reality
#5
Uqba Khan, Humaira Rizvi, Farman Ali, Daniel Lebovic
Sweet syndrome is a rare disorder that is manifested by constellation of clinical features, including fever, neutrophilic leucocytosis, raised painful plaques on skin and dermal infiltration by neutrophils. Numerous aetiological associations have been reported in the literature, including various haematological malignancies and drugs. Our case was peculiar because of association of capecitabine and Sweet syndrome in rectal cancer. We describe a case of a woman aged 57 years, with recently diagnosed stage III rectal cancer, developed painful erythematous rash over her face along with fever and headache...
December 23, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27974672/long-term-outcomes-and-propensity-score-matching-analysis-rectal-cancer-resection-for-patients-with-elevated-preoperative-risk
#6
Hao Feng, Tobias S Schiergens, Zhi-Hai Mao, Jingkun Zhao, Xiaohui Shen, Ai-Guo Lu, Wolfgang E Thasler
BACKGROUND: It is still controversial about the treatment strategy for rectal cancer patients with elevated operative risk and elder rectal cancer patients. METHODS: This study presented a retrospective single center experience in rectal cancer proctectomy for high operative risk patients. High operative risk patient was defined as Cr-POSSUM > 5% combined with associated risk factors. 220 in 1477 consecutive patients met the inclusion criteria. RESULTS: 132 patients were selected (66:66) after propensity score matching...
December 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27939006/colorectal-cancer-quality-of-surgical-care-in-michigan
#7
Arielle Kanters, Andrew J Mullard, Jennifer Arambula, Laurie Fasbinder, Greta Krapohl, Sandra L Wong, Darrell A Campbell, Samantha Hendren
OBJECTIVE: Surgery remains the cornerstone therapy for colorectal cancer (CRC). This study assesses CRC quality measures for surgical cases in Michigan. METHODS: In this retrospective cohort study, processes of care and outcomes for CRC resection cases were abstracted in 30 hospitals in the Michigan Surgical Quality Collaborative (2014-2015). Measures were case-mix and reliability adjusted, using logistic regression models. RESULTS: For 871 cases (640 colon cancer, 231 rectal cancer), adjusted morbidity (27...
November 27, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27936129/characteristics-of-differently-located-colorectal-cancers-support-proximal-and-distal-classification-a-population-based-study-of-57-847-patients
#8
Jiao Yang, Xiang Lin Du, Shu Ting Li, Bi Yuan Wang, Yin Ying Wu, Zhe Ling Chen, Meng Lv, Yan Wei Shen, Xin Wang, Dan Feng Dong, Dan Li, Fan Wang, En Xiao Li, Min Yi, Jin Yang
BACKGROUND: It has been suggested that colorectal cancer be regarded as several subgroups defined according to tumor location rather than as a single entity. The current study aimed to identify the most useful method for grouping colorectal cancer by tumor location according to both baseline and survival characteristics. METHODS: Cases of pathologically confirmed colorectal adenocarcinoma diagnosed from 2000 to 2012 were identified from the Surveillance, Epidemiology, and End Results database and categorized into three groups: right colon cancer (RCC), left colon cancer (LCC), and rectal cancer (ReC)...
2016: PloS One
https://www.readbyqxmd.com/read/27935051/the-survival-impact-of-delayed-surgery-and-adjuvant-chemotherapy-on-stage-ii-iii-rectal-cancer-with-pathological-complete-response-after-neoadjuvant-chemoradiation
#9
Feng-Che Kuan, Chia-Hsuan Lai, Hsiu-Ying Ku, Chun-Feng Wu, Meng-Chiao Hsieh, Tsang-Wu Liu, Chien-Yuh Yeh, Kuan-Der Lee
Neoadjuvant concurrent chemoradiation (CCRT) is standard treatment for clinical stage II/III rectal cancers. However, whether patients with pathological complete response (pT0N0, pCR) should receive adjuvant chemotherapy and whether delayed surgery will influence the pCR rate remains controversial. A nationwide population study was conducted using the Taiwan Cancer Registry Database from January 2007 to December 2013. Kaplan-Meier survival analysis was performed. Cox proportional hazards models were used to estimate multivariate adjusted hazard ratios (HR) and 95% confidence intervals (95% CI)...
December 9, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27932667/lymph-node-yield-is-an-independent-predictor-of-survival-in-rectal-cancer-regardless-of-receipt-of-neoadjuvant-therapy
#10
Zhaomin Xu, Mariana E Berho, Adan Z Becerra, Christopher T Aquina, Bradley J Hensley, Reza Arsalanizadeh, Katia Noyes, John R T Monson, Fergal J Fleming
AIMS: Lymph node yield (LNY) is used as a marker of adequate oncological resection. The American Joint Committee on Cancer (AJCC) currently recommends that at least 12 nodes are necessary to confirm node-negative disease for rectal cancer. A LNY of 12 is not always achieved, particularly in patients who have undergone neoadjuvant treatment. This study attempts to examine factors associated with LNY and its prognostic impact following neoadjuvant chemoradiation in rectal cancer. METHODS: The 2006-2011 National Cancer Data Base was queried for patients with clinical stage I-III rectal cancer who underwent a proctectomy...
December 8, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27929437/the-traditional-chinese-medicine-dangguibuxue-tang-sensitizes-colorectal-cancer-cells-to-chemoradiotherapy
#11
Shun-Ting Chen, Tzung-Yan Lee, Tung-Hu Tsai, Yin-Cheng Lin, Chin-Ping Lin, Hui-Ru Shieh, Ming-Ling Hsu, Chih-Wen Chi, Ming-Cheng Lee, Hen-Hong Chang, Yu-Jen Chen
Chemotherapy is an important treatment modality for colon cancer, and concurrent chemoradiation therapy (CCRT) is the preferred treatment route for patients with stage II and III rectal cancer. We examined whether DangguiBuxue Tang (DBT), a traditional Chinese herbal extract, sensitizes colorectal cancer cells to anticancer treatments. The polysaccharide-depleted fraction of DBT (DBT-PD) contains greater amounts of astragaloside IV (312.626 µg/g) and ferulic acid (1.404 µg/g) than does the original formula...
December 6, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27928792/-clinicopathological-characteristics-and-prognosis-analysis-of-colorectal-neuroendocrine-neoplasms-based-on-the-data-from-domestic-six-medical-centers
#12
Yu Zhang, Xiaojie Peng, Kaizhou Jin, Wei Wang, Xingyu Feng, Yujie Zeng, Minhu Chen, Xianjun Yu, Ye Chen, Jie Chen
OBJECTIVE: To investigate the clinicopathological characteristics and their relationship with prognosis of colorectal neuroendocrine neoplasms (NEN). METHODS: Medical records of 329 patients with colorectal NEN between June 2001 and July 2016 from 6 large scale centers in China were reviewed to investigate the clinicopathological characteristics and their relationship with prognosis of colorectal NEN. RESULTS: (1) Colonic NEN: A total of 41 patients with colonic NEN were enrolled from The First Affiliated Hospital of Sun Yat-sen University(n=11), Sun Yat-sen University Cancer Center (n=15), Guangdong General Hospital (n=10), Sun Yet-san Memorial Hospital of Sun Yat-sen University (n=3) and Fudan University Shanghai Cancer Center (n=2)...
November 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27903247/preoperative-conventional-chemoradiotherapy-versus-short-course-radiotherapy-with-delayed-surgery-for-rectal-cancer-results-of-a-randomized-controlled-trial
#13
Tadas Latkauskas, Henrikas Pauzas, Laura Kairevice, Aleksandras Petrauskas, Zilvinas Saladzinskas, Rasa Janciauskiene, Jurate Gudaityte, Paulius Lizdenis, Saulius Svagzdys, Algimantas Tamelis, Dainius Pavalkis
BACKGROUND: There still is no evidence which neoadjuvant therapy regimen for stage II-III rectal cancer is superior. The aim of this study was to compare results achieved after long-course chemoradiotherapy (CRT) with short-term radiotherapy (RT) followed by delayed surgery. METHODS: A randomized trial was carried out between 2007-2013. One hundred fifty patients diagnosed with stage II-III rectal cancer were randomized into one of two neoadjuvant treatment arms: conventional chemoradiotherapy (CRT) and short-term radiotherapy (RT) followed by surgery after 6-8 weeks...
December 1, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27881048/accuracy-of-pre-treatment-locoregional-rectal-cancer-staging-in-a-national-improvement-project
#14
Bart Op de Beeck, Peter Smeets, Freddy Penninckx, Piet Pattyn, Geert Silversmit, Elizabeth Van Eycken
BACKGROUND: The aim of this study was to assess the accuracy, particularly the predictive value, of locoregional clinical rectal cancer staging (cTN) and its variability in a national improvement project. METHODS: cTN stages and the distance between tumour and mesorectal fascia (MRF) were compared with histopathological findings in 1168 patients who underwent radical resection without neoadjuvant treatment. Data were registered prospectively from 2006 to 2014. RESULTS: Agreement between clinical and histopathological TN stages was 50%, independent of tumour location...
November 24, 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27864695/adjuvant-chemotherapy-improves-overall-survival-of-rectal-cancer-patients-treated-with-neoadjuvant-chemoradiotherapy-regardless-of-pathologic-nodal-status
#15
Audrey S Kulaylat, Christopher S Hollenbeak, David B Stewart
BACKGROUND: After neoadjuvant chemoradiotherapy for rectal cancer, the interpretation of surgical pathology poses difficulties in deciding the need for adjuvant chemotherapy (AC). The aim of this study was to determine whether there is a survival benefit to providing AC in patients with node-negative disease on surgical pathology. METHODS: Patients with clinical stage II and III rectal adenocarcinoma who received neoadjuvant chemoradiation and definitive surgical resection from 2006 to 2012 were identified in the National Cancer Data Base...
November 18, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27856366/advanced-stage-colorectal-cancer-in-persons-younger-than-50-years-not-associated-with-longer-duration-of-symptoms-or-time-to-diagnosis
#16
Frank W Chen, Vandana Sundaram, Thomas A Chew, Uri Ladabaum
BACKGROUND & AIMS: The incidence of colorectal cancer (CRC) is increasing in the United States among adults younger than the age of 50 years. Studies of young-onset CRC have focused on outcomes and treatment patterns. We examined patient presentation, provider evaluation, and time to diagnosis, which can affect stage and prognosis. METHODS: In a retrospective study, we collected data from patients with a diagnosis of colorectal adenocarcinoma, confirmed by pathologists, seen at the Stanford Cancer Institute from January 1, 2008, through December 31, 2014...
November 14, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27849668/risk-of-acute-testicular-failure-after-preoperative-radiotherapy-for-rectal-cancer-a-prospective-cohort-study
#17
Christian Buchli, Anna Martling, Massoud Al Abani, Jan-Erik Frödin, Matteo Bottai, Ingmar Lax, Stefan Arver, Torbjörn Holm
OBJECTIVE: The aim of this study was to assess the acute effect of preoperative RT for rectal cancer on endocrine testicular function. BACKGROUND: Preoperative radiotherapy (RT) enhances local control and cancer-specific survival in patients treated for rectal cancer. In case series, a negative acute effect on Leydig cell function has been reported. METHODS: This prospective cohort study included 168 males with rectal or prostate cancer stage I-III...
November 15, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27830030/vnn1-overexpression-is-associated-with-poor-response-to-preoperative-chemoradiotherapy-and-adverse-prognosis-in-patients-with-rectal-cancers
#18
Chi-Yung Chai, Yimin Zhang, Junlong Song, Shih-Chun Lin, Shengrong Sun, I-Wei Chang
BACKGROUND: Colorectal cancer is prevalent worldwide and it is also the fourth most common cause of cancer mortality. For rectal cancer, neoadjuvant concurrent chemoradiotherapy (CCRT) followed by radical proctectomy is gold standard treatment for patients with stage II/III rectal cancer. By data mining a public dataset of rectal cancer transcriptome (GSE35452) from Gene Expression Omnibus, National Center of Biotechnology Information (GEO, NCBI), we identified that VNN1 was the most significantly upregulated gene among those related to nitrogen compound metabolic process (GO:0006807)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27826780/multicentre-propensity-score-matched-analysis-of-laparoscopic-versus-open-surgery-for-t4-rectal-cancer
#19
Nicola de'Angelis, Filippo Landi, Giulio Cesare Vitali, Riccardo Memeo, Aleix Martínez-Pérez, Alejandro Solis, Michela Assalino, Francesc Vallribera, Henry Alexis Mercoli, Jacques Marescaux, Didier Mutter, Frédéric Ris, Eloy Espin, Francesco Brunetti
BACKGROUND: The use of laparoscopy for advanced-stage rectal cancer remains controversial. This study aimed to compare the operative and oncologic outcomes of laparoscopic (LAR) versus open anterior rectal resection (OAR) for patients with pT4 rectal cancer. METHODS: This is a multicenter propensity score matching (PSM) study of patients undergoing elective curative-intent LAR or OAR for pT4 rectal cancer (TNM stage II/III/IV) between 2005 and 2015. RESULTS: In total, 137 patients were included in the analysis...
November 8, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27821321/unemployment-risk-at-2-and-4-years-following-colorectal-cancer-diagnosis-a-population-based-study
#20
Yakir Rottenberg, Navah Z Ratzon, Miri Cohen, Ayala Hubert, Beatrice Uziely, Angela G E M de Boer
BACKGROUND: About half of colorectal patients are diagnosed less than 65 years of age and they have a relatively high cure rate. However, little is known about their employment and related risk factors. The aim of the current study was to clarify the association between colorectal cancer (CRC) and subsequent risk of being unemployed. METHODS: A historical prospective cohort study included baseline socio-demographic measurements of age, sex, ethnicity, residential socio-economic position and education from the 1995 Israeli National Census, cancer incidence between 2000 and 2007 and employment data between 1998 and 2011...
November 4, 2016: European Journal of Cancer
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