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III stage colon cancer

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https://www.readbyqxmd.com/read/29045507/reply-to-the-letter-to-the-editor-including-lynch-syndrome-in-personalized-prognostication-and-follow-up-of-stage-ii-and-iii-colon-cancer-by-sciallero-et-al
#1
R Dienstmann, J Guinney
No abstract text is available yet for this article.
August 2, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29038964/surgical-and-oncological-outcomes-after-complete-mesocolic-excision-in-right-sided-colon-cancer-compared-with-conventional-surgery-a-retrospective-single-institution-study
#2
Tommaso Zurleni, Alberto Cassiano, Elson Gjoni, Andrea Ballabio, Giovanni Serio, Luca Marzoli, Francesco Zurleni
PURPOSE: The aim of the study was whether complete mesocolic excision (CME) with central vascular ligation (CVL) is associated with a survival benefit compared with traditional procedure in right-sided colon cancer. METHODS: Overall, 251 consecutive patients underwent surgery for right colon cancer between 2007 and 2012. After exclusion, 95 subjects received non-CME surgery before 2010, and 97 subjects received CME surgery after January 2010, when we started to perform CME systematically...
October 16, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29037017/preoperative-chemoradiotherapy-versus-postoperative-chemoradiotherapy-for-stage-ii-iii-resectable-rectal-cancer-a-meta-analysis-of-randomized-controlled-trials
#3
Jin Ho Song, Jae Uk Jeong, Jong Hoon Lee, Sung Hwan Kim, Hyeon Min Cho, Jun Won Um, Hong Seok Jang
PURPOSE: Whether preoperative chemoradiotherapy (CRT) is better than postoperative CRT in oncologic outcome and toxicity is contentious in prospective randomized clinical trials. We systematically analyze and compare the treatment result, toxicity, and sphincter preservation rate between preoperative CRT and postoperative CRT in stage II-III rectal cancer. MATERIALS AND METHODS: We searched Medline, Embase, and Cochrane Library from 1990 to 2014 for relevant trials...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29034042/description-of-the-surgical-strategy-used-for-the-treatment-of-a-complex-disease-report-of-a-case
#4
Kazuki Kihara, Miwa Tashiro, Kohei Miyashita, Masaki Yamamoto, Hironobu Hirose, Takashi Fukutomi, Hideaki Nishimori, Kazumasa Orihashi
We report a rare case in which a patient required three surgeries with competing priorities. In a 68-year-old man diagnosed with an abdominal aortic aneurysm (AAA), computed tomography (CT) revealed an infrarenal AAA, unusual thickening of the sigmoid colon that suggested cancer, and a filling defect in the left atrium. We considered the disease stage, which affects prognosis, and the risk of complications that could interfere with the treatment of the other pathologies and developed a three-stage surgical strategy: (i) endovascular aortic repair, (ii) sigmoid colectomy, and (iii) resection of the left atrial mass...
June 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29032319/peri-operative-blood-transfusion-for-resected-colon-cancer-practice-patterns-and-outcomes-in-a-population-based-study
#5
Sunil V Patel, Kelly E Brennan, Sulaiman Nanji, Safiya Karim, Shaila Merchant, Christopher M Booth
BACKGROUND & OBJECTIVES: Literature suggests that peri-operative blood transfusion among patients with resected colon cancer may be associated with inferior long-term survival. The study objective was to characterize this association in our population. METHODS: This is a retrospective cohort study using the population-based Ontario Cancer Registry (2002-2008). Pathology reports were obtained for a 25% random sample of all cases and constituted the study population...
October 12, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29025530/intensive-follow-up-after-curative-surgery-for-colorectal-cancer
#6
Rita Vale Rodrigues, João Pereira da Silva, Isadora Rosa, Isabel Santos, Nuno Pereira, Carla Soares, António Dias Pereira
INTRODUCTION: The purpose of postoperative surveillance programs after curative treatment for colorectal cancer is to detect asymptomatic recurrences with the premise that an important rate will be eligible for curative resection, improving overall survival. We have implemented a surveillance program for patients with colorectal cancer, stages II-III, with periodic clinical, carcinoembryonic antigen and cancer antigen-19-9 assessment, computed tomography and colonoscopy. The aim of this study was to assess the rate of curative treatment of recurrence, colorectal cancer mortality and clinical characteristics associated with non-resectable recurrence...
September 29, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29018055/dose-response-effects-of-exercise-on-insulin-among-colon-cancer-survivors
#7
Justin Brown, Michael Rickels, Andrea Troxel, Babette Zemel, Nevena Damjanov, Bonnie Ky, Andrew Rhim, Anil Rustgi, Kerry S Courneya, Kathryn Schmitz
Physical activity is associated with a lower risk of disease recurrence among colon cancer survivors. The pathways through which physical activity may alter disease outcomes are unknown, but may include changes in metabolic growth factors, such as insulin. METHODS: Between January 2015 and August 2015, 39 stage I-III colon cancer survivors were randomized to one of three groups: usual-care control, 150 min∙wk-1 of aerobic exercise (low-dose), and 300 min∙wk-1 of aerobic exercise (high-dose) for six months...
October 10, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28991080/prospective-trial-evaluating-the-surgical-anastomosis-at-one-year-colorectal-cancer-surveillance-ct-colonography-versus-optical-colonoscopy-and-implications-for-patient-care
#8
MULTICENTER STUDY
Perry J Pickhardt, Kristin Edwards, David H Bruining, Marc Gollub, Sonja Kupfer, Sam J Lubner, David H Kim, Eric Ross, Eileen Keenan, David S Weinberg
OBJECTIVE: The aim of this study was to compare the accuracy of CT colonography versus optical colonoscopy for neoplastic involvement at the surgical anastomosis 1 year after curative-intent colorectal cancer resection. DESIGN, SETTING, PATIENTS, AND INTERVENTIONS: Two hundred one patients (mean age, 58.6 years; 117 men, 84 women) underwent same-day contrast-enhanced CT colonography and colonoscopy approximately 1 year (mean, 12.1 months; median, 11.9 months) after colorectal cancer resection as part of a prospective, multicenter trial...
November 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28983557/role-of-deficient-dna-mismatch-repair-status-in-patients-with-stage-iii-colon-cancer-treated-with-folfox-adjuvant-chemotherapy-a-pooled-analysis-from-2-randomized-clinical-trials
#9
Aziz Zaanan, Qian Shi, Julien Taieb, Steven R Alberts, Jeffrey P Meyers, Thomas C Smyrk, Catherine Julie, Ayman Zawadi, Josep Tabernero, Enrico Mini, Richard M Goldberg, Gunnar Folprecht, Jean Luc Van Laethem, Karine Le Malicot, Daniel J Sargent, Pierre Laurent-Puig, Frank A Sinicrope
Importance: The prognostic impact of DNA mismatch repair (MMR) status in stage III colon cancer patients receiving FOLFOX (folinic acid, fluorouracil, and oxaliplatin) adjuvant chemotherapy remains controversial. Objective: To determine the association of MMR status with disease-free survival (DFS) in patients with stage III colon cancer treated with FOLFOX. Design, Setting, and Participants: The evaluated biomarkers for MMR status were determined from prospectively collected tumor blocks from patients treated with FOLFOX in 2 open-label, phase 3 randomized clinical trials: NCCTG N0147 and PETACC8...
October 5, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28981199/microrna-661-modulates-redox-and-metabolic-homeostasis-in-colon-cancer
#10
Marta Gómez de Cedrón, Rebeca Acín Pérez, Ruth Sánchez-Martínez, Susana Molina, Jesús Herranz, Jaime Feliu, Guillermo Reglero, Jose Antonio Enríquez, Ana Ramírez de Molina
Cancer cell survival and metastasis are dependent on metabolic reprogramming that is capable of increasing resistance to oxidative and energetic stress. Targeting these two processes can be crucial for cancer progression. Herein, we describe the role of microRNA-661 (miR661) as epigenetic regulator of colon cancer (CC) cell metabolism. miR661 induces a global increase in reactive oxygen species (ROS), specifically in mitochondrial superoxide anions (SO(-) ), which appears to be mediated by decreased carbohydrate metabolism and pentose phosphate pathway, and by a higher dependency on mitochondrial respiration...
October 5, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28980383/incidence-of-venous-thromboembolic-events-in-enhanced-recovery-after-surgery-for-colon-cancer-a-retrospective-population-based-cohort-study
#11
Momo M I Vendler, Tamim A Haidari, Jo E Waage, Jakob Kleif, Bent Kristensen, Ismail Gögenur, Claus A Bertelsen
AIM: Both the Danish and NICE guidelines recommend prolonged thromboprophylaxis (PT) with low-molecular-weight heparin (LMWH) for 28 days postoperatively after elective surgery for colon cancer. The evidence relies on two RCTs that included not only colon cancers but also other abdominal cancers or benign colorectal diseases. Neither of those studies investigated the risk of venous thromboembolism (VTE) under Enhanced Recovery After Surgery (ERAS). We aim to describe the risk of VTE and estimate the cost of preventing one case of VTE by PT under ERAS...
October 4, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28978563/potential-medication-related-problems-in-older-breast-colon-and-lung-cancer-patients-in-the-united-states
#12
Jennifer L Lund, Hanna K Sanoff, Sharon Peacock-Hinton, Hyman Muss, Virginia Pate, Til Stürmer
BACKGROUND: Older adults are often exposed to multiple medications, some of which could be inappropriate or have the potential to interact with each other. Older cancer patients may be at increased risk for medication-related problems due to exposure to cancer-directed treatment. METHODS: We described patterns of potentially inappropriate medication (PIM) use and potential drug-chemotherapy interactions among adults age 66+ years diagnosed with stage I-III breast, stage II-III colon, and stage I-II lung cancer...
October 4, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28976805/single-port-and-conventional-laparoscopy-in-colorectal-surgery-comparison-of-two-techniques
#13
Udit Gibor, Zvi Perry, Sergey Domchik, Solly Mizrahi, Boris Kirshtein
BACKGROUND: Single-incision laparoscopic surgery (SILS) was introduced to further the enhanced outcome of conventional multiport laparoscopy (CML). We compared their short- and long-term outcomes in colorectal surgery. MATERIALS AND METHODS: Retrospective review of patients who underwent elective laparoscopic colorectal surgery during 3-year period. Patients' data, surgery outcomes, and oncological results were compared. RESULTS: Sixty-one patients (33 male, 28 female), mean age 67...
October 4, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28974887/circulating-inflammatory-factors-associated-with-worse-long-term-prognosis-in-colorectal-cancer
#14
Renate S Olsen, Johnny Nijm, Roland E Andersson, Jan Dimberg, Dick Wågsäter
AIM: To investigate association of circulating inflammatory factors at the time of colorectal cancer (CRC) surgery with survival. METHODS: Plasma levels from 174 CRC patients (69 females and 105 men), with median age 70 years (range 29-90), localized in the colon (n = 105) or rectum (n = 69), with stage I (n = 24), stage II (n = 54), stage III (n = 67) and stage IV (n = 29) were measured using commercially available Bio-Plex Pro™ Human Chemokine Panel 40-Plex, including 40 different chemokines, cytokines and interleukins...
September 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28972653/some-stage-iii-colon-cancer-patients-may-need-only-half-of-the-standard-chemotherapy-course
#15
Carrie Printz
No abstract text is available yet for this article.
October 15, 2017: Cancer
https://www.readbyqxmd.com/read/28949060/safety-quality-and-effect-of-complete-mesocolic-excision-versus-non-complete-mesocolic-excision-in-patients-with-colon-cancer-a-systemic-review-and-meta-analysis
#16
REVIEW
Chao Wang, Zhidong Gao, Kai Shen, Zhanlong Shen, Kewei Jiang, Bin Liang, Mujun Yin, Xiaodong Yang, Shan Wang, Yingjiang Ye
AIM: The application of complete mesocolic excision (CME) in colon cancer is controversial. We performed a meta-analysis to compare the safety, quality and effect of CME with non-complete mesocolic excision (NCME) in patients with colon cancer. METHOD: We searched PubMed, ScienceDirect, the Cochrane Library, and Scopus to identify studies comparing CME with NCME in colon cancer. We focused on three study outcome areas: safety (operation time, blood loss, complications, mortality); quality (large bowel length, distance from the tumour to the high vascular tie, area of mesentery, total lymph nodes); and effect (long-term survival)...
September 26, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28945832/including-lynch-syndrome-in-personalized-prognostication-and-follow-up-of-stage-ii-and-iii-colon-cancer
#17
S Sciallero, L Battistuzzi, L Varesco
No abstract text is available yet for this article.
October 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28939585/mediating-effect-of-postsurgical-chemotherapy-on-presence-of-dementia-and-survival-among-patients-65-and-older-with-stage-iii-colon-cancer
#18
Yingjia Chen, Rosemary D Cress, Susan L Stewart, Thomas J Semrad, Danielle Harvey, Daniel J Tencredi, Laurel Beckett
Introduction: Both colon cancer and dementia are prevalent among the elderly and have a high risk of cooccurrence. Previous studies found that patients with dementia were treated less aggressively. In this study, we hypothesized that presence of preexisting dementia was associated with worse survival for stage III colon cancer patients, and that postoperative chemotherapy was on the causal pathway.Methods: We defined preexisting dementia in Surveillance Epidemiology and End Results Medicare data through either a formal diagnosis or a prescription for dementia drugs or both before the diagnosis of cancer...
September 22, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28935353/oncologic-significance-of-para-aortic-lymph-node-and-inferior-mesenteric-lymph-node-metastasis-in-sigmoid-and-rectal-adenocarcinoma
#19
Seung Hyung Lee, Jong Lyul Lee, Chan Wook Kim, Han Il Lee, Chang Sik Yu, Jin Cheon Kim
BACKGROUND: Recurrence patterns or survival in colorectal cancer patients might differ according to inferior mesenteric lymph node (IMLN) metastasis. However, few studies have compared para-aortic lymph node (PALN) metastasis and IMLN metastasis. The aim of the current study is to identify survival and recurrence patterns in patients with sigmoid colon and rectal adenocarcinoma with either PALN or IMLN metastasis and to evaluate the prognostic significance of PALN and IMLN metastasis...
September 7, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28934762/dose-response-effects-of-aerobic-exercise-on-body-composition-among-colon-cancer-survivors-a-randomised-controlled-trial
#20
Justin C Brown, Babette S Zemel, Andrea B Troxel, Michael R Rickels, Nevena Damjanov, Bonnie Ky, Andrew D Rhim, Anil K Rustgi, Kerry S Courneya, Kathryn H Schmitz
BACKGROUND: Physical activity is associated with a lower risk of disease recurrence among colon cancer survivors. Excess visceral adipose tissue is associated with a higher risk of disease recurrence among colon cancer survivors. The pathways through which physical activity may alter disease outcomes are unknown, but may be mediated by changes in visceral adipose tissue. METHODS: Thirty-nine stage I-III colon cancer survivors were randomised to one of three groups: usual-care control, 150 min wk(-1) of aerobic exercise (low dose) and 300 min wk(-1) of aerobic exercise (high dose) for 6 months...
September 21, 2017: British Journal of Cancer
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