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III stage colon cancer

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https://www.readbyqxmd.com/read/28210851/in-vivo-and-ex-vivo-sentinel-node-mapping-does-not-identify-the-same-lymph-nodes-in-colon-cancer
#1
Helene Schou Andersen, Astrid Louise Bjørn Bennedsen, Stefan Kobbelgaard Burgdorf, Jens Ravn Eriksen, Susanne Eiholm, Anders Toxværd, Lene Buhl Riis, Jacob Rosenberg, Ismail Gögenur
INTRODUCTION: Identification of lymph nodes and pathological analysis is crucial for the correct staging of colon cancer. Lymph nodes that drain directly from the tumor area are called "sentinel nodes" and are believed to be the first place for metastasis. The purpose of this study was to perform sentinel node mapping in vivo with indocyanine green and ex vivo with methylene blue in order to evaluate if the sentinel lymph nodes can be identified by both techniques. METHODS: Patients with colon cancer UICC stage I-III were included from two institutions in Denmark from February 2015 to January 2016...
February 16, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28184430/prediction-of-overall-survival-in-stage-ii-and-iii-colon-cancer-beyond-tnm-system-a-retrospective-pooled-biomarker-study
#2
R Dienstmann, M J Mason, F A Sinicrope, A I Phipps, S Tejpar, A Nesbakken, S A Danielsen, A Sveen, D D Buchanan, M Clendenning, C Rosty, B Bot, S R Alberts, J Milburn Jessup, R A Lothe, M Delorenzi, P A Newcomb, D Sargent, J Guinney
No abstract text is available yet for this article.
February 9, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28179352/factors-associated-with-the-lack-of-adjuvant-chemotherapy-following-curative-surgery-for-stage-ii-and-iii-colon-cancer-a-korean-national-cohort-study
#3
Gye Sung Ha, Young Wan Kim, Eun Hee Choi, Ik Yong Kim
BACKGROUND: To evaluate factors associated with the lack of adjuvant chemotherapy after curative surgery in patients with stage II and III colon cancer based on national population-based data. PATIENTS AND METHODS: A total of 8,412 patients diagnosed with stage II or III disease who underwent curative resection were included. RESULTS: Adjuvant chemotherapy was not administered in 3,057 cases (36.34%). Factors associated with the lack of chemotherapy were older age [hazard ratio (HR)=1...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28173877/bilateral-ovarian-micrometastatic-adenocarcinoma-upon-prophylactic-oophorectomy-concurrent-with-low-anterior-resection-for-rectal-cancer
#4
Robin Irons, Erin McIntosh, Alexandre Hageboutros, David Warshal, Steven McClane
BACKGROUND: This case report draws attention to the debated role of prophylactic oophorectomy in women undergoing definitive surgical resection of colon and rectal cancers. It can be challenging to discern the indications and appropriate patient population for this procedure based on the current literature. Potential benefits include treatment and prevention of metastatic disease, preventing development of primary ovarian cancer, and prolonging survival. Negative effects include an increase in operative time and potential morbidity, development of osteoporosis, the risk of cardiac events, and decreasing sexual function...
February 7, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28165633/back-to-the-future-routine-morphological-assessment-of-the-tumour-microenvironment-is-prognostic-in-stage-ii-iii-colon-cancer-in-a-large-population-based-study
#5
Seán O Hynes, Helen G Coleman, Paul J Kelly, Steven Irwin, Roisin F O'Neill, Ronan T Gray, Claire McGready, Philip D Dunne, Stephen McQuaid, Jacqueline A James, Manuel Salto-Tellez, Maurice B Loughrey
AIMS: Both morphological and molecular approaches have highlighted the biological and prognostic importance of the tumour microenvironment in colorectal cancer (CRC). Despite this, microscopic assessment of tumour microenvironment has not been adopted into routine practice. METHODS AND RESULTS: Based on existing evidence, we selected specific morphological features relating to peritumoral inflammatory and stromal responses, agreed criteria for scoring, and assessed these in representative H&E-stained whole tumour sections, from a population-based cohort of 445 stage II/III colon cancer cases...
February 6, 2017: Histopathology
https://www.readbyqxmd.com/read/28157065/complete-mesocolic-excision-an-assessment-of-feasibility-and-outcome
#6
Claus Anders Bertelsen
Surgery is the most important factor for radical treatment of colon cancer, and the long-term prognosis can be improved by improving the surgical treatment without increased risk of perioperative mortality. Complete mesocolic excision (CME), in which more extensive lymph node (LN) dissection is performed, has been shown in single-centre studies with historical controls to be associated with better oncological outcome. However, better evidence is needed. The main purpose of this PhD thesis was to investigate whether CME could be implemented in a colorectal surgical department in Denmark, whether more extensive dissection could demonstrate LN metastases outside the mesocolon, and to demonstrate a possible association between CME and improved oncological results without increased risk of perioperative mortality...
February 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28152795/integrated-post-surgical-colon-cancer-care-planning-at-the-rutgers-cancer-institute-of-new-jersey-and-robert-wood-johnson-university-hospital
#7
Kristen Donohue, Sondra Patella, Viktor Y Dombrovskiy, Rebecca Anne Moss, Nell Maloney Patel
: 75 Background: Colorectal cancer is the second leading cause of cancer death in the United States each year. The use of adjuvant chemotherapy after surgical resection of colon cancer has been associated with a survival benefit. Timely initiation of adjuvant chemotherapy has been shown to have an effect on overall and disease-free survival. There is no integrated post-surgical colon cancer care planning for patients who have surgery at our institution. Poor understanding on the part of patients and ancillary providers regarding appropriate follow up may cause delay in time to adjuvant chemotherapy initiation...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152734/effect-of-insurance-status-on-receiving-standard-quality-care-treatment-in-patients-with-stage-iii-colon-cancer
#8
Lihong Liu, Hemangini Dhaibar, Glenn Morris Mills, Runhua Shi
: 45 Background: NCCN (National comprehensive Cancer network) recommends adjuvant chemotherapy for stage 3 colon cancer patients. National Cancer Data Base (NCDB) data were analyzed to investigate the impact of insurance status on receiving standard quality of care with adjuvant chemotherapy for stage 3 colon cancer patients. METHODS: Data was analyzed from 11,563 men and women, between ages 18-80 years, registered in the NCDB who were diagnosed with stage 3 colon cancer between 1998 and 2011 and had follow-ups to end of 2012...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28139499/desmoplasia-influenced-recurrence-of-disease-and-mortality-in-stage-iii-colorectal-cancer-within-five-years-after-surgery-and-adjuvant-therapy
#9
Maddalena Zippi, Giorgio De Toma, Giovanni Minervini, Claudio Cassieri, Roberta Pica, Diodoro Colarusso, Simon Stock, Pietro Crispino
BACKGROUND/AIMS: In patients with colon cancer who undergo resection for potential cure, 40-60% have advanced locoregional disease (stage III). Those who are suitable for adjuvant treatment had a definite disease-free-survival benefit. The aim of the present study was to demonstrate whether the presence of desmoplasia influenced the mortality rate of stage III colorectal cancer (CRC) within 5 years from the surgery and adjuvant therapy. PATIENTS AND METHODS: Sixty-five patients with stage III CRC underwent resection and adjuvant therapy...
January 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28133230/-a-case-of-locally-advanced-gallbladder-cancer-that-developed-early-multiple-liver-metastasis-after-curative-resection-and-achieved-long-termpartial-remission-using-s-1-and-gemcitabine
#10
Sakurao Hiraki, Kou Kanesada, Toshio Harada, Kousuke Tada, Shintaro Fukuda
A 76-year-old woman was referred to our hospital because of an abdominal tumor in September 2009. An irregularly shaped large tumor was detected in the right subcostal abdominal cavity on computed tomography, and was diagnosed as advanced gallbladder cancer without distant metastasis following further examination. We then performed a laparotomy. The tumor had invaded directly into the descending portion of the duodenum and transverse colon. We performed a curative resection of the tumor macroscopically. Pathological findings were moderately differentiated tubular adenocarcinoma derived from gallbladder cancer(T3N0M0, Stage III )...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133086/-usefulness-of-transnasal-decompression-tubes-in-patients-with-right-sided-obstructive-colorectal-cancer
#11
Ryouichi Tomita, Shigeru Fujisaki, Takeo Azuhata, Yuko Takamoto, Kenichi Sakurai
PURPOSE: We performed this retrospective study to evaluate the usefulness of a transnasal decompression tube(long ileus tube)as a bridge to surgery in patients with right-sided obstructive colorectal cancer. PATIENTS AND METHODS: There were 8 patients(5 men and 3 women, aged 64 to 85 years with a mean age of 75.9 years)who had undergone transnasal decom- pression in the last 10 years. RESULT: 1) The success rate of intubation was 100%(8/8)...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28131669/-what-if-i-do-nothing-the-natural-history-of-operable-cancer-of-the-alimentary-tract
#12
H B Keshava, J E Rosen, M R DeLuzio, A W Kim, F C Detterbeck, D J Boffa
INTRODUCTION: "Natural history", or anticipated survival without treatment, is critical for patients weighing risks and benefits of cancer surgery. Current estimates concerning the natural history of cancer includes patients whose poor health precludes treatment; a cohort whose fate is likely distinctly worse than those eligible for surgery ("operable"). The study objective was to evaluate survival among patients recommended for cancer surgery but went untreated, to determine the natural history of "operable" alimentary tract cancer...
January 18, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28130276/subgroups-and-prognostication-in-stage-iii-colon-cancer-future-perspectives-for-adjuvant-therapy
#13
E Auclin, A Zaanan, D Vernerey, R Douard, C Gallois, P Laurent-Puig, F Bonnetain, J Taieb
Since the MOSAIC study, oxaliplatin-based adjuvant chemotherapy has been the standard treatment for stage III colon cancer. Combination therapy with fluoropyrimidines and oxaliplatin has improved overall survival (OS) and reduced the risk of recurrence in patients with resected stage III colon cancer. However, only 20% of patients really benefit from adjuvant chemotherapy, exposing 80% of patients to unnecessary toxicity. Recent analyses of large multicenter adjuvant studies have focused on the prognostication of OS and disease free survival (DFS) in stage III colon cancer in order to reduce over-treatment and to find more accurate prognostic tools than those used for adjuvant treatment decision-making in stage II disease...
January 27, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28128413/protective-role-of-294-t-c-rs2016520-polymorphism-of-ppard-in-mexican-patients-with-colorectal-cancer
#14
M A Rosales-Reynoso, L I Wence-Chavez, A R Arredondo-Valdez, S Dumois-Petersen, P Barros-Núñez, M P Gallegos-Arreola, S E Flores-Martínez, J Sánchez-Corona
PPARD encodes for peroxisome proliferator-activated receptor delta, which plays a significant role in controlling lipid metabolism, atherosclerosis, inflammation, cancer growth, progression, and apoptosis. Accumulated evidence suggests that the polymorphism rs2016520 in PPARD is associated with lipid metabolism, obesity, metabolic syndrome, and type 2 diabetes mellitus. The aim of this study was to determine whether the single nucleotide polymorphism +294T/C (rs2016520) in PPARD is associated with colorectal cancer (CRC) in the Mexican population...
January 23, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28125800/peroxiredoxin-2-is-associated-with-colorectal-cancer-progression-and-poor-survival-of-patients
#15
LingLong Peng, Rong Wang, Ling Xiang, JinBao Guo, JinLai Wei, JingKun Shang, WenXian You, YongFu Xiong, ZhongXue Fu
The present study was to investigate the clinical significance of peroxiredoxin 2 (PRDX2), an oncoenzyme, in the development and progression of colorectal cancer(CRC).We found levels of PRDX2 mRNA and protein were higher in CRC cell lines than in normal human colonic epithelial cells. PRDX2 expression was significantly up-regulated in CRC lesions compared with that in the adjacent noncancerous tissues. CRC tissues from 148 of 226 (65.5%) patients revealed high level of PRDX2 protein expression in contrast to only 13 of 226 (5...
January 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28122847/need-for-general-practitioner-involvement-and-ehealth-in-colon-cancer-survivorship-care-patients-perspectives
#16
Ineke C Nugteren, Laura A M Duineveld, Thijs Wieldraaijer, Henk C P M van Weert, Irma M Verdonck-de Leeuw, Cornelia F van Uden-Kraan, Jan Wind
BACKGROUND: As colon cancer is increasingly becoming a chronic illness with a broad range of symptoms, there is a need for individually tailored care for these patients. OBJECTIVE: To investigate patients' opinions about GP involvement in survivorship care and the use of eHealth applications, such as Oncokompas(2.0), to support self-management. Oncokompas(2.0) is an interactive website that monitors quality of life via participant-reported outcomes and provides feedback and personalized supportive care...
January 24, 2017: Family Practice
https://www.readbyqxmd.com/read/28119864/obstructive-left-colon-cancer-should-be-managed-by-using-a-subtotal-colectomy-instead-of-colonic-stenting
#17
Chung Ki Min, Hyung Ook Kim, Donghyoun Lee, Kyung Uk Jung, Sung Ryol Lee, Hungdai Kim, Ho-Kyung Chun
PURPOSE: This study compared a subtotal colectomy to self-expandable metallic stent (SEMS) insertion as a bridge to surgery for patients with left colon-cancer obstruction. METHODS: Ninety-four consecutive patients with left colon-cancer obstruction underwent an emergency subtotal colectomy or elective SEMS insertion between January 2007 and August 2014. Using prospectively collected data, we performed a retrospective comparative analysis on an intention-to-treat basis...
December 2016: Annals of Coloproctology
https://www.readbyqxmd.com/read/28105622/-association-of-peripheral-nerve-invasion-with-clinicopathological-factors-and-prognosis-of-colorectal-cancer
#18
Dong Han, Ying Wei, Xidi Wang, Geng Wang, Yinggang Chen
OBJECTIVE: To investigate the association of peripheral nerve invasion (PNI) with clinicopathological factors and prognosis of colorectal cancer. METHODS: Clinicopathological data and Surgical specimens of 372 colorectal cancer patients who underwent radical resection from January 2011 to June 2012 in The Second Affiliated Hospital of Harbin Medical University were collected. Histopathological evaluation of tissue samples was conducted with hematoxylin and eosin-stained sections...
January 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28103922/assessment-and-diagnostic-accuracy-of-lymph-node-status-to-predict-stage-iii-colon-cancer-using-computed-tomography
#19
Erik Rollvén, Mirna Abraham-Nordling, Torbjörn Holm, Lennart Blomqvist
BACKGROUND: To study different imaging criteria for prediction of lymph node metastases (Stage III disease) in colon cancer using CT. METHODS: In a retrospective setting, 483 consecutive patients with histology proven colon cancer underwent elective primary resection during 2008-2011, a cohort of 119 patients were included. Contrast enhanced CT examinations, in portal-venous phase, were reviewed with assessment of the number of lymph nodes, their anatomical distribution, size, size ratio, internal heterogeneity, presence of irregular outer border and attenuation values...
January 19, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28101757/final-report-of-kscc0803-feasibility-study-of-capecitabine-as-adjuvant-chemotherapy-for-stage-iii-colon-cancer-in-japan
#20
Kazuhito Minami, Masaru Morita, Yasunori Emi, Masahiro Okamoto, Eiji Tanaka, Shigeyuki Nagata, Tetsuo Touyama, Kippei Ohgaki, Takaho Tanaka, Hiroshi Okumura, Toyokuni Suenaga, Shoji Tokunaga, Eiji Oki, Yoshihiro Kakeji, Yoshito Akagi, Hideo Baba, Shoji Natsugoe, Yoshihiko Maehara
BACKGROUND: The impact of oral capecitabine as adjuvant chemotherapy for Japanese patients with resected colon cancer was unclear. We previously planned and conducted a prospective feasibility study (KSCC0803) and reported on the safety of oral capecitabine as adjuvant chemotherapy for Japanese patients with resected stage III colon cancer. The purpose of the current study was to assess the survival results from that study. METHODS: The study subjects were Japanese patients with resected stage III colon cancer...
January 18, 2017: International Journal of Clinical Oncology
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