keyword
https://read.qxmd.com/read/38528940/risk-of-primary-gastrointestinal-lymphoma-in-patients-with-inflammatory-conditions-exposed-to-tumor-necrosis-factor-alpha-inhibitors-and-immunomodulators-a-case-control-study
#1
JOURNAL ARTICLE
Manuel B Braga-Neto, Jason Nasser, Xiao Xing Iris Wang, William Scott Harmsen, Laura E Raffals, Michael Camilleri, Victor Chedid
INTRODUCTION: The aim of this case-control study was to determine if exposure to tumor necrosis factor alpha inhibitors (TNFIs) or immunomodulators (thiopurines or methotrexate) was associated with development of primary gastrointestinal lymphoma (PGIL) in patients with chronic inflammatory conditions. METHODS: Patients with PGIL and controls evaluated at a tertiary care center over 20 years were matched 1:3 using a medical record informatics search engine based on their chronic inflammatory condition (Crohn's disease [CD], ulcerative colitis [UC], rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis) and duration of follow-up...
January 2024: Crohn's & colitis 360
https://read.qxmd.com/read/38504503/drug-reactive-metabolite-induced-hepatotoxicity-a-comprehensive-review
#2
REVIEW
Piyush Mahajan, Mahesh Palkar, Ravindra Babu Pingili
Nowadays, drug-induced liver toxicity (DILT) is one of the main contributing factors to severe liver disease. In the United States (US) alone, DILT is the cause of more than 50% of instances of acute liver failure. Prescription or over-the-counter drugs, xenobiotics, and herbal and nutritional supplements can cause DILT and could produce anomalies in hepatic function tests. Some drugs induce hepatotoxicity directly, and others induce it indirectly (i. e. through their toxic or reactive metabolites). Currently, the United States Food and Drug Administration (US FDA) has issued black box warnings to about 1279 drugs due to their hepatotoxicity...
March 19, 2024: Toxicology Mechanisms and Methods
https://read.qxmd.com/read/38480674/distal-toxic-acral-erythema-and-mucositis-secondary-to-6-mercaptopurine-in-a-thiopurine-methyltransferase-super-shunter
#3
Sydney Smith, Daniel Grove
Toxic erythema of chemotherapy is a broad but useful diagnosis used to summate the non-infectious, non-allergic, and reproducible reaction of certain chemotherapeutics. Due to overlapping chemotherapy side effects and often multiple drug exposures, identification of a singular culprit drug is challenging for dermatologists. Herein, we report a patient with 6-mercaptopurine (6-MP) toxic erythema confirmed via toxic metabolite markers secondary to increased levels of thiopurine methyltransferase activity, or so called "super shunting...
March 13, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38457659/assessment-of-dna-rna-deregulation-in-cancer-using-99m-tc-labeled-thiopurine
#4
JOURNAL ARTICLE
Chuang-Hsin Chiu, David J Yang, Yi-Chen Liou, Wei-Chung Chang, Tsung-Hsun Yu, Min-Ching Chung, Yen-Chun Lee, Ing-Jou Chen, Pao-Yeh Wang, Ching-Po Lin, Hey-Jen Tsay, Skye Hsin-Hsien Yeh
Background: DNA biomarkers are useful for the assessment of tumor cell proliferation. The authors aimed to synthesize a thiopurine-based ligand for evaluation of nuclear uptake and tumor localization. Materials and Methods: A 2-hydroxypropyl spacer was incorporated between a chelator (cyclam) and thiopurine ligand to produce SC-06-L1. In vitro cellular uptake and the cell/media ratios of [99m Tc]Tc-SC-06-L1 were assessed in breast (MCF-7, MDA-MB-231) and ovarian (TOV-112D, OVCAR3) cancer cells. The nuclear and cytosolic uptake ratio of [99m Tc]Tc-SC-06-L1 was determined in OVCAR-3 and MCF-7 cells...
March 8, 2024: Cancer Biotherapy & Radiopharmaceuticals
https://read.qxmd.com/read/38452742/evaluation-of-genetic-variants-associated-with-the-risk-of-thiopurine-related-pancreatitis-a-case-control-study-from-eneida-registry
#5
JOURNAL ARTICLE
Ivan Guerra, Francisco Barros, María Chaparro, José M Benítez, María Dolores Martín-Arranz, Ruth de Francisco, Marta Piqueras, Luisa de Castro, Ana Y Carbajo, Fernando Bermejo, Miguel Mínguez, Ana Gutiérrez, Francisco Mesonero, Fiorella Cañete, Carlos González-Muñoza, Marta Calvo, Beatriz Sicilia, Erika Alfambra, Montserrat Rivero, Alfredo J Lucendo, Carlos A Tardillo, Pedro Almela, Luis Bujanda, Manuel van Domselaar, Laura Ramos, María Fernández Sánchez, Esther Hinojosa, Cristina Verdejo, Anna Gimenez, Iago Rodríguez-Lago, Noemí Manceñido, José L Pérez Calle, Mónica Del Pilar Moreno, Pedro Genaro Delgado-Guillena, Beatriz Antolín, Patricia Ramírez de la Piscina, María José Casanova, Pilar Soto Escribano, Eduardo Martín Arranz, Isabel Pérez-Martínez, Raquel Mena, Natalia García Morales, Alicia Granja, Marta Maia Boscá Watts, Rubén Francés, Cristina Fernández, Margalida Calafat, Cristina Roig-Ramos, María Isabel Vera, Ángel Carracedo, Eugeni Domènech, Javier P Gisbert
BACKGROUND: Risk factors for developing pancreatitis due to thiopurines in patients with inflammatory bowel disease (IBD) are not clearly identified. AIM: Our aim was to evaluate the predictive pharmacogenetic risk of pancreatitis in IBD patients treated with thiopurines. METHODS: We conducted an observational pharmacogenetic study of acute pancreatitis events in a cohort study of IBD patients treated with thiopurines from the prospectively maintained ENEIDA registry biobank of GETECCU...
March 7, 2024: Digestive Diseases
https://read.qxmd.com/read/38445247/effectiveness-and-safety-of-azathioprine-for-inflammatory-pouch-disorders-results-from-the-reservo-study-of-geteccu
#6
JOURNAL ARTICLE
Francisco Mesonero, Yamile Zabana, Agnès Fernández-Clotet, Eduardo Leo-Carnerero, Berta Caballol, Andrea Núñez-Ortiz, María José García, Federico Bertoletti, Alejandro Mínguez, Gerard Suris, Begoña Casis, Rocío Ferreiro-Iglesias, Margalida Calafat, Itxaso Jiménez, José Miranda-Bautista, Luis Javier Lamuela, Ingrid Fajardo, Leyanira Torrealba, Rodrigo Nájera, Rosa María Sáiz-Chumillas, Irene González, Miren Vicuña, Natalia García-Morales, Ana Gutiérrez, Alicia López-García, José Manuel Benítez, Cristina Rubín de Célix, Coral Tejido, Eduard Brunet, Alejandro Hernández-Camba, Cristina Suárez, Iago Rodríguez-Lago, Marta Piqueras, Andrés Castaño, Laura Ramos, Ana Sobrino, María Carmen Rodríguez-Grau, Alfonso Elosua, Miguel Montoro, Ruth Baltar, José María Huguet, Benito Hermida, Antonio Caballero-Mateos, Luis Sánchez-Guillén, Abdel Bouhmidi, Ramón Pajares, Iria Baston-Rey, Antonio López-Sanromán, Agustin Albillos, Manuel Barreiro-de Acosta
BACKGROUND: The usefulness of thiopurines has been poorly explored in pouchitis and other pouch disorders. OBJECTIVE: To evaluate the effectiveness and safety of azathioprine as maintenance therapy in inflammatory pouch disorders. DESIGN: This was a retrospective and multicentre study. METHODS: We included patients diagnosed with inflammatory pouch disorders treated with azathioprine in monotherapy. Effectiveness was evaluated at 1 year and in the long term based on normalization of stool frequency, absence of pain, faecal urgency or fistula discharge (clinical remission), or any improvement in these symptoms (clinical response)...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38445003/withdrawal-versus-continuation-of-thiopurine-in-vedolizumab-treated-patients-with-ulcerative-colitis-views-a-multi-centre-randomised-controlled-trial
#7
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
July 2023: Gastroenterology & Hepatology
https://read.qxmd.com/read/38444060/efficacy-of-optimised-thiopurine-therapy-in-patients-with-moderate-to-severe-ulcerative-colitis-retrospective-long-term-follow-up-from-two-randomised-trials
#8
JOURNAL ARTICLE
Anette Mertz Nielsen, Klaus Theede, Lise Lotte Gluud, Marianne Kiszka-Kanowitz
OBJECTIVE: The long-term outcome of thiopurine therapy in patients with ulcerative colitis (UC) enrolled in prospective trials have not been evaluated. We aimed to assess the effects of optimised thiopurine maintenance therapy for UC. METHODS: Long-term data were obtained from patients from our center enrolled in two randomised, prospective, open-label, controlled studies comprising 66 thiopurine-naïve moderate-to-severe patients with UC consisting of a low dose azathioprine (AZA)/allopurinol combination or AZA monotherapy...
March 5, 2024: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/38401141/editorial-towards-optimal-thiopurine-therapy-for-inflammatory-bowel-disease
#9
EDITORIAL
Elsa L S A van Liere, Nanne K H de Boer
No abstract text is available yet for this article.
March 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38401137/editorial-towards-optimal-thiopurine-therapy-for-inflammatory-bowel-disease-authors-reply
#10
EDITORIAL
Abhinav Vasudevan, Danny Con, Daniel R van Langenberg
No abstract text is available yet for this article.
March 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38399389/antiviral-potential-of-azathioprine-and-its-derivative-6-mercaptopurine-a-narrative-literature-review
#11
REVIEW
Carolina Rios-Usuga, Marlen Martinez-Gutierrez, Julian Ruiz-Saenz
The use of azathioprine (AZA) in human medicine dates back to research conducted in 1975 that led to the development of several drugs, including 6-mercaptopurine. In 1958, it was shown that 6-mercaptopurine decreased the production of antibodies against earlier administered antigens, raising the hypothesis of an immunomodulatory effect. AZA is a prodrug that belongs to the thiopurine group of drugs that behave as purine analogs. After absorption, it is converted into 6-mercaptopurine. Subsequently, it can be degraded through various enzymatic pathways into inactive compounds and biologically active compounds related to the mechanism of action, which has been the subject of study to evaluate a possible antiviral effect...
January 30, 2024: Pharmaceuticals
https://read.qxmd.com/read/38386080/synthesis-and-crystal-structure-of-a-silver-i-6-methylmercaptopurine-riboside-complex
#12
JOURNAL ARTICLE
Lamia L G Al-Mahamad, William Clegg
Silver nitrate reacts with 6-methylmercaptopurine riboside (6-MMPR) in aqueous solution containing methanol and dimethyl sulfoxide at room temperature to give a colourless crystalline complex, namely, bis(6-methylmercaptopurine riboside-κN7 )(nitrato-κ2 O,O')silver(I) 2.32-hydrate, [Ag(NO3 )(C11 H14 N4 O4 S)2 ]·2.32H2 O. The crystal structure, determined from synchrotron diffraction data, shows a central AgI ion on a crystallographic twofold rotation axis, coordinated in an almost linear fashion by two 6-MMPR ligands via atom N7 (purine numbering), with the nitrate counter-ion loosely coordinated as a bidentate ligand, forming a discrete molecular complex as an approximate dihydrate...
March 1, 2024: Acta Crystallographica. Section C, Structural Chemistry
https://read.qxmd.com/read/38384282/the-drug-survival-of-low-dose-thioguanine-in-patients-with-inflammatory-bowel-disease-a-retrospective-observational-study
#13
JOURNAL ARTICLE
Helena Gensmyr-Singer, Mårten Werner, Pontus Karling
BACKGROUND: Thiopurines are commonly used to treat inflammatory bowel disease but withdrawal due to side effects are common. Thioguanine has been suggested to be better tolerated than conventional thiopurines. OBJECTIVES: We studied drug-survival of low dose of thioguanine in real-life clinical practice in comparison to conventional thiopurines. DESIGN: Retrospective observational study. METHODS: All patients born 1956 and later, and who at least once started thiopurine treatment between 2006 and 2022 were included...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38383877/uphill-battle-innovation-of-thiopurine-therapy-in-global-inflammatory-bowel-disease-care
#14
REVIEW
Ahmed B Bayoumy, Chris J J Mulder, Azhar R Ansari, Murray L Barclay, Tim Florin, Marianne Kiszka-Kanowitz, Luc Derijks, Vishal Sharma, Nanne K H de Boer
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that encompasses two major conditions: Crohn's disease (CD) and ulcerative colitis (UC). Historically, IBD has been primarily reported in western countries, but over the past decades, its prevalence is rapidly increasing, especially in lower and middle-income countries (LMICs) such as India and China and also in Sub-Saharan Africa. The prevalence of IBD in LMICs has been the subject of growing concern due to the impact of access to public healthcare and the burden it places on healthcare resources...
February 21, 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/38380724/therapeutic-drug-monitoring-of-vedolizumab-therapy-in-inflammatory-bowel-disease
#15
JOURNAL ARTICLE
Casper Steenholdt, Ruben Due Lorentsen, Pernille Nørgaard Petersen, Ella Sk Widigson, Charlotte Kloft, Rolf Anton Klaasen, Jørn Brynskov
BACKGROUND: Therapeutic drug monitoring is effective for optimizing anti-tumor necrosis factor therapies in inflammatory bowel disease, but for vedolizumab, a gut-selective leucocyte migration inhibitor, data are scarce. METHODS: Observational cohort study including 116 bio-experienced inflammatory bowel disease patients treated with vedolizumab for active luminal disease. Biobanked trough blood samples (n = 676) covering 96% of patients were analyzed using a drug-binding immunofluorometric assay...
February 21, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38379902/-nudt15-and-tpmt-polymorphisms-in-three-distinct-native-populations-of-the-brazilian-amazon
#16
JOURNAL ARTICLE
Jamila Alessandra Perini, Paulo Cesar Basta, Guilherme Suarez-Kurtz
This is the first report of the distribution of TPMT and NUDT15 single nucleotide polymorphisms and metabolic phenotypes associated with cytotoxicity of thiopurine drugs, in indigenous groups of Brazilian Amazon: Munduruku, Paiter-Suruí and Yanomami. The minor allele frequency (MAF) of NUDT15 rs116855232 did not differ significantly across the groups; TPMT rs1800462 was absent, while rs1800460 and rs1142345 were in strong linkage disequilibrium, and 10- and 30-fold more common in Paiter-Suruí. Indeed, the MAFs in Paiter-Surui (0...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38366352/thiopurine-metabolite-shunting-in-late-pregnancy-increases-the-risk-of-intrahepatic-cholestasis-of-pregnancy-in-women-with-inflammatory-bowel-disease-and-can-be-managed-with-split-dosing
#17
JOURNAL ARTICLE
Ralley Prentice, Emma Flanagan, Emily Wright, Lani Prideaux, William Connell, Miles Sparrow, Peter De Cruz, Mark Lust, Winita Hardikar, Rimma Goldberg, Sara Vogrin, Kirsten Palmer, Alyson Ross, Megan Burns, Tessa Greeve, Sally Bell
BACKGROUND AND AIMS: The risk of intrahepatic cholestasis of pregnancy (ICP) is increased in thiopurine exposed pregnancies. Thiopurine 'shunting', with a 6-methylmecrcaptopurine (MMP) to 6-thioguanine (TGN) ratio of >11, progresses over pregnancy, and may promote ICP development. We aimed to explore the association between thiopurine exposure and ICP, including the hypothesized impact of thiopurine shunting, and identify risk minimization strategies. METHODS: This prospective multi-centre cohort study compared thiopurine and biologic monotherapy exposed pregnant participants...
February 15, 2024: Journal of Crohn's & Colitis
https://read.qxmd.com/read/38358251/epstein-barr-virus-seroprevalence-among-inflammatory-bowel-disease-patients-in-saudi-arabia
#18
JOURNAL ARTICLE
Badr Al-Bawardy, Abdulaziz F Alfadley, Mohammed Almousallam, Saad AlShathri, Mohamed Aboueissa, Abdulrahman Alsulaiman, Mashary Attamimi, Abdulelah AlMutairdi
BACKGROUND: Seroprevalence of Epstein-Barr virus (EBV) in patients with inflammatory bowel disease (IBD) is variable based on geographic distribution. There are no published data on the seroprevalence of EBV in patients with IBD in Saudi Arabia. This study aims to assess the seroprevalence of EBV in patients with IBD in a tertiary center in Saudi Arabia. METHODS: This is a retrospective chart review of patients ≥14 years of age with a confirmed diagnosis of IBD and known EBV status at our institution from January 1, 2018, to January 1, 2023...
February 15, 2024: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/38356449/effects-of-allopurinol-on-6-mercaptopurine-metabolism-in-unselected-patients-with-pediatric-acute-lymphoblastic-leukemia-a-prospective-phase-ii-study
#19
JOURNAL ARTICLE
Jonatan Källström, Riita Niinimäki, Johan Fredlund, Hartmut Vogt, Laura Korhonen, Anders Castor, Josefine Palle, Arja Harila, Magnus Borssén, Jonas Abrahamsson, Torben Ek
Allopurinol can be used in maintenance therapy (MT) for pediatric acute lymphoblastic leukemia (ALL) to mitigate hepatic toxicity in patients with skewed 6- mercaptopurine metabolism. Allopurinol increases the erythrocyte levels of thioguanine nucleotides (e-TGN), which is the proposed main mediator of the antileukemic effect and decreases methyl mercaptopurine (e-MeMP) levels, associated with hepatotoxicity. We investigated the effects of allopurinol in thiopurine methyltransferase (TPMT) wild-type patients without previous clinical signs of skewed 6MP metabolism...
February 15, 2024: Haematologica
https://read.qxmd.com/read/38347433/tofacitinib-use-in-ulcerative-colitis-an-expert-consensus-for-day-to-day-clinical-practice
#20
JOURNAL ARTICLE
Rupa Banerjee, Vishal Sharma, Rajendra Patel, Anuraag Jena, Partha Pal, Nalini Raghunathan, Ajay Kumar, Ajit Sood, Amarender S Puri, Bhabhadev Goswami, Devendra Desai, Dhanush Mekala, G N Ramesh, G V Rao, Kiran Peddi, Mathew Philip, Manu Tandon, Shobna Bhatia, Shubhankar Godbole, Sumit Bhatia, Uday C Ghoshal, Usha Dutta, Vandana Midha, V G Mohan Prasad, D Nageshwar Reddy
Rising number of inflammatory bowel disease (IBD) cases in developing countries necessitate clear guidance for clinicians for the appropriate use of advanced therapies. An expert consensus document was generated to guide the usage of tofacitinib, a Janus kinase inhibitor, in ulcerative colitis. Tofacitinib is a useful agent for the induction and maintenance of remission in ulcerative colitis. It can be used in the setting of biological failure or even steroid-dependent and thiopurine refractory disease...
February 12, 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
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