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Stress related mucosal disease

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https://www.readbyqxmd.com/read/27733718/prevalence-of-deleterious-oral-habits-and-oral-mucosal-lesions-among-fishermen-population-of-mahe-south-india
#1
Ksa Anzil, J Mathews, A G Sai, M Kiran, S Kevin, S Sunith
INTRODUCTION: Fishing is an occupation associated with uneven diet, strain, drunkenness, tobacco use, and deleterious habits. The physical state of laborers on a large scale will also be influenced by conditions at their work site. Oral mucosal lesions can occur as a result of infections, local shock or infuriation, systemic diseases, and uncontrolled usage of tobacco, betel quid, and alcohol. The aim of the present study is to assess the prevalence of deleterious oral habits and oral mucosal lesions among fishermen population of Mahe, South India...
September 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27635116/protective-effect-of-amphipterygium-adstringens-extract-on-dextran-sulphate-sodium-induced-ulcerative-colitis-in-mice
#2
Mario Rodriguez-Canales, Ruben Jimenez-Rivas, Maria Margarita Canales-Martinez, Ana Judith Garcia-Lopez, Nelly Rivera-Yañez, Oscar Nieto-Yañez, Yadira Ledesma-Soto, Luvia Enid Sanchez-Torres, Miriam Rodriguez-Sosa, Luis Ignacio Terrazas, Marco Aurelio Rodriguez-Monroy
Amphipterygium adstringens is an endemic species in Mexico commonly known as "cuachalalate." Healers to treat gastritis, gastric ulcers, and gastrointestinal cancer have traditionally used the bark. We investigated the effects of alcoholic extract of A. adstringens (AaEE) in DSS-induced colitis in mice. The protective effect of AaEE was determined at 200 mg/kg by oral gavage for 10 days. We determine the effect of AaEE on clinical features (disease activity index), antioxidants, anti-inflammatory, and immunomodulatory activities in relation to the activity of SOD, CAT, and GPx, levels of proinflammatory cytokines, and changes both macroscopic and microscopic of the colonic mucosa...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27452660/antiinflammatory-and-immunomodulatory-activity-of-an-ethanolic-extract-from-the-stem-bark-of-terminalia-catappa-l-combretaceae-in-vitro-and-in-vivo-evidences
#3
Oyindamola O Abiodun, Alba Rodríguez-Nogales, Francesca Algieri, Ana Maria Gomez-Caravaca, Antonio Segura-Carretero, M Pilar Utrilla, M Elena Rodriguez-Cabezas, Julio Galvez
ETHNOPHARMOCOLOGICAL RELEVANCE: Terminalia catappa Linn (Combretaceae) is a medicinal plant with anti-inflammatory, anti-diarrhoeal and antioxidant properties, frequently found in tropical regions. Considering its characteristics, it could be useful for the treatment of inflammatory bowel disease, which is associated with inflammation, oxidative stress and an immune dysfunction. Thus this study evaluates the immunomodulatory properties and the intestinal anti-inflammatory effect of an ethanolic extract of the stem bark of T...
November 4, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27446898/study-protocol-on-hormonal-mediation-of-exercise-on-cognition-stress-and-immunity-pro-hmecsi-effects-of-different-exercise-programmes-in-institutionalized-elders
#4
Ana Maria Teixeira, José Pedro Ferreira, Eef Hogervorst, Margarida Ferreira Braga, Stephan Bandelow, Luís Rama, António Figueiredo, Maria João Campos, Guilherme Eustáquio Furtado, Matheus Uba Chupel, Filipa Martins Pedrosa
Physical activity (PA) in elders has been shown to have positive effects on a plethora of chronic diseases and to improve immunity, mental health, and cognition. Chronic stress has also been shown to have immuno-suppressive effects and to accelerate immunosenescence. Exercise could be a significant factor in ameliorating the deleterious effects of chronic stress, but variables such as the type, intensity, and frequency of exercise that should be performed in order to effectively reduce the stress burden need to be defined clearly...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27404394/systems-toxicology-assessment-of-the-biological-impact-of-a-candidate-modified-risk-tobacco-product-on-human-organotypic-oral-epithelial-cultures
#5
Filippo Zanetti, Alain Sewer, Carole Mathis, Anita R Iskandar, Radina Kostadinova, Walter K Schlage, Patrice Leroy, Shoaib Majeed, Emmanuel Guedj, Keyur Trivedi, Florian Martin, Ashraf Elamin, Céline Merg, Nikolai V Ivanov, Stefan Frentzel, Manuel C Peitsch, Julia Hoeng
Cigarette smoke (CS) has been reported to increase predisposition to oral cancer and is also recognized as a risk factor for many conditions including periodontal diseases, gingivitis, and other benign mucosal disorders. Smoking cessation remains the most effective approach for minimizing the risk of smoking-related diseases. However, reduction of harmful constituents by heating rather than combusting tobacco, without modifying the amount of nicotine, is a promising new paradigm in harm reduction. In this study, we compared effects of exposure to aerosol derived from a candidate modified risk tobacco product, the tobacco heating system (THS) 2...
August 15, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27279158/-irritable-bowel-syndrome-emotion-regulation-and-gut-microbiota
#6
Shin Fukudo
Irritable bowel syndrome (IBS) is defined as a representative functional gastrointestinal disorder which is characterized by chronic or recurrent abdominal pain and/or abdominal discomfort associated with abnormal bowel movement. Gut microbiota are related to the pathophysiology of IBS. In the field of IBS, post-infectious etiology, stress-induced alteration of microbiota, increased mucosal permeability, bacterial overgrowth, disease-specific microbiota, microbial products, and brain-gut interactions are being investigated...
June 2016: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/27274339/association-between-serotonin-transporter-gene-polymorphism-and-recurrent-aphthous-stomatitis
#7
Aastha Manchanda, Asha R Iyengar, Seema Patil
BACKGROUND: Anxiety-related traits have been attributed to sequence variability in the genes coding for serotonin transmission in  the brain. Two alleles, termed long (L) and short (S) differing by 44 base pairs, are found in a polymorphism identified in the promoter region of serotonin transporter gene. The presence of the short allele  and SS and LS genotypes is found to be associated with the reduced expression of this gene decreasing the uptake of serotonin in the brain leading to various anxiety-related traits...
May 2016: Dental Research Journal
https://www.readbyqxmd.com/read/27187687/a-nomogram-for-predicting-complications-in-patients-with-solid-tumours-and-seemingly-stable-febrile-neutropenia
#8
Paula Jiménez Fonseca, Alberto Carmona-Bayonas, Ignacio Matos García, Rosana Marcos, Eduardo Castañón, Maite Antonio, Carme Font, Mercè Biosca, Ana Blasco, Rebeca Lozano, Avinash Ramchandani, Carmen Beato, Eva Martínez de Castro, Javier Espinosa, Jerónimo Martínez-García, Ismael Ghanem, Jorge Hernando Cubero, Isabel Aragón Manrique, Francisco García Navalón, Elena Sevillano, Aránzazu Manzano, Juan Virizuela, Marcelo Garrido, Rebeca Mondéjar, María Ángeles Arcusa, Yaiza Bonilla, Quionia Pérez, Elena Gallardo, Maria Del Carmen Soriano, Mercè Cardona, Fernando Sánchez Lasheras, Juan Jesús Cruz, Francisco Ayala
BACKGROUND: We sought to develop and externally validate a nomogram and web-based calculator to individually predict the development of serious complications in seemingly stable adult patients with solid tumours and episodes of febrile neutropenia (FN). PATIENTS AND METHODS: The data from the FINITE study (n=1133) and University of Salamanca Hospital (USH) FN registry (n=296) were used to develop and validate this tool. The main eligibility criterion was the presence of apparent clinical stability, defined as events without acute organ dysfunction, abnormal vital signs, or major infections...
May 24, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27133563/saccharomyces-cerevisiae-ufmg-a-905-treatment-reduces-intestinal-damage-in-a-murine-model-of-irinotecan-induced-mucositis
#9
R W Bastos, S H S P Pedroso, A T Vieira, L M C Moreira, C S França, C T Cartelle, R M E Arantes, S V Generoso, V N Cardoso, M J Neves, J R Nicoli, F S Martins
Indigenous microbiota plays a crucial role in the development of several intestinal diseases, including mucositis. Gastrointestinal mucositis is a major and serious side effect of cancer therapy, and there is no effective therapy for this clinical condition. However, some probiotics have been shown to attenuate such conditions. To evaluate the effects of Saccharomyces cerevisiae UFMG A-905 (Sc-905), a potential probiotic yeast, we investigated whether pre- or post-treatment with viable or inactivated Sc-905 could prevent weight loss and intestinal lesions, and maintain integrity of the mucosal barrier in a mucositis model induced by irinotecan in mice...
September 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27087247/altered-mucosal-microbiome-diversity-and-disease-severity-in-sj%C3%A3-gren-syndrome
#10
Cintia S de Paiva, Dan B Jones, Michael E Stern, Fang Bian, Quianta L Moore, Shani Corbiere, Charles F Streckfus, Diane S Hutchinson, Nadim J Ajami, Joseph F Petrosino, Stephen C Pflugfelder
There is mounting evidence that the microbiome has potent immunoregulatory functions. We assessed the effects of intestinal dysbiosis in a model of Sjögren syndrome (SS) by subjecting mice to desiccating stress (DS) and antibiotics (ABX). We characterized the conjunctival, tongue and fecal microbiome profiles of patients with SS. Severity of ocular surface and systemic disease was graded. 16S ribosomal RNA gene sequencing characterized the microbiota. ABX + DS mice had a significantly worse dry eye phenotype compared to controls, a decrease in Clostridium and an increase in Enterobacter, Escherichia/Shigella, and Pseudomonas in stool after ABX + DS for 10 days...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27040468/mechanisms-by-which-stress-affects-the-experimental-and-clinical-inflammatory-bowel-disease-ibd-role-of-brain-gut-axis
#11
Bartosz Brzozowski, Agnieszka Mazur-Bialy, Robert Pajdo, Slawomir Kwiecien, Jan Bilski, Malgorzata Zwolinska-Wcislo, Tomasz Mach, Tomasz Brzozowski
BACKGROUND: Stress of different origin is known to alter so called "brain-gut axis" and contributes to a broad array of gastrointestinal disorders including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and other functional gastrointestinal diseases. The stressful situations and various stressors including psychosocial events, heat, hypo- and hyperthermia may worsen the course of IBD via unknown mechanism. The aims of this paper were to provide an overview of experimental and clinical evidences that stress activates the brain-gut axis which results in a mucosal mast cells activation and an increase in the production of proinflammatory cytokines and other endocrine and humoral mediators...
April 4, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/26981846/lactoferrin-a-pleiotropic-protein-in-health-and-disease
#12
Sylvain Mayeur, Schohraya Spahis, Yves Pouliot, Emile Levy
SIGNIFICANCE: Lactoferrin (Lf) is a nonheme iron-binding glycoprotein strongly expressed in human and bovine milk and it plays many functions during infancy such as iron homeostasis and defense against microorganisms. In humans, Lf is mainly expressed in mucosal epithelial and immune cells. Growing evidence suggests multiple physiological roles for Lf after weaning. RECENT ADVANCES: The aim of this review is to highlight the recent advances concerning multifunctional Lf activities...
May 10, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/26855894/prevention-of-stress-related-ulcer-bleeding-at-the-intensive-care-unit-risks-and-benefits-of-stress-ulcer-prophylaxis
#13
REVIEW
Lukas Buendgens, Alexander Koch, Frank Tacke
Stress-related mucosal disease is a typical complication of critically ill patients in the intensive care unit (ICU). It poses a risk of clinically relevant upper gastrointestinal (GI) bleeding. Therefore, stress ulcer prophylaxis (SUP) is recommended in high-risk patients, especially those mechanically ventilated > 48 h and those with a manifest coagulopathy. Proton pump inhibitors (PPI) and, less effectively, histamine 2 receptor antagonists (H2RA) prevent GI bleeding in critically ill patients in the ICU...
February 4, 2016: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/26769837/the-influence-of-pretreatment-with-ghrelin-on-the-development-of-acetic-acid-induced-colitis-in-rats
#14
D Maduzia, A Matuszyk, D Ceranowicz, Z Warzecha, P Ceranowicz, K Fyderek, K Galazka, A Dembinski
Ghrelin has been primarily shown to exhibit protective and therapeutic effect in the gut. Pretreatment with ghrelin inhibits the development of acute pancreatitis and accelerates pancreatic recovery in the course of this disease. In the stomach, ghrelin reduces gastric mucosal damage induced by ethanol, stress or alendronate, as well as accelerates the healing of acetic acid-induced gastric and duodenal ulcer. The aim of present studies was to investigate the effect of pretreatment with ghrelin on the development of acetic acid-induced colitis...
December 2015: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/26739521/nerve-growth-factor-and-diarrhea-predominant-irritable-bowel-syndrome-ibs-d-a-potential-therapeutic-target
#15
REVIEW
Xiao-juan Xu, Liang Liu, Shu-kun Yao
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by recurrent abdominal pain or discomfort associated with abnormal bowel habits. Diarrhea-predominant IBS (IBS-D) is a major subtype of IBS, the predominant manifestations of which are abdominal pain and diarrhea. The pathogenesis of IBS-D remained unknown until recently. The effects of psychosocial stress, central hypervigilance, neuroendocrine abnormality, disturbed gastrointestinal motility, mucosal immune activation, intestinal barrier dysfunction, visceral hypersensitivity (VH), altered gut flora, and genetic susceptibility may be involved in its development...
January 2016: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/26701350/impact-of-maintenance-therapy-for-the-prevention-of-peri-implant-diseases-a-systematic-review-and-meta-analysis
#16
REVIEW
A Monje, L Aranda, K T Diaz, M A Alarcón, R A Bagramian, H L Wang, A Catena
At the present time, peri-implantitis has become a global burden that occurs with a frequency from 1% to 47% at implant level. Therefore, we aimed herein at assessing the impact of peri-implant maintenance therapy (PIMT) on the prevention of peri-implant diseases. Electronic and manual literature searches were conducted by 3 independent reviewers using several databases, including MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Cochrane Oral Health Group Trials Register, for articles up to June 2015 without language restriction...
April 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/26604089/protective-effect-of-butyrate-against-ethanol-induced-gastric-ulcers-in-mice-by-promoting-the-anti-inflammatory-anti-oxidant-and-mucosal-defense-mechanisms
#17
Jiaming Liu, Fangyan Wang, Haihua Luo, Aihua Liu, Kangxin Li, Cui Li, Yong Jiang
Gastric ulcers (GUs) are a common type of peptic ulcer. Alcohol overdose is one of the main causes of GU, which is difficult to prevent. Although the protective effect of butyrate on inflammation-related diseases is well understood, its effect on GUs has not been reported. We investigated the protective effects of butyrate against ethanol-induced lesions to the gastric mucosa in mice and the underlying mechanisms. BALB/c mice were orally pretreated with butyrate for 30min prior to the establishment of the GU model by challenge with absolute ethanol...
January 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/26488273/candida-albicans-biofilms-and-human-disease
#18
REVIEW
Clarissa J Nobile, Alexander D Johnson
In humans, microbial cells (including bacteria, archaea, and fungi) greatly outnumber host cells. Candida albicans is the most prevalent fungal species of the human microbiota; this species asymptomatically colonizes many areas of the body, particularly the gastrointestinal and genitourinary tracts of healthy individuals. Alterations in host immunity, stress, resident microbiota, and other factors can lead to C. albicans overgrowth, causing a wide range of infections, from superficial mucosal to hematogenously disseminated candidiasis...
2015: Annual Review of Microbiology
https://www.readbyqxmd.com/read/26457023/resveratrol-a-potential-challenger-against-gastric-cancer
#19
REVIEW
Aida Zulueta, Anna Caretti, Paola Signorelli, Riccardo Ghidoni
Gastric cancer (GC) is the fourth most common cancer and the second leading cause of cancer-related mortality in the world. Late diagnosis and classical therapeutic approaches such as surgery, chemotherapy and radiotherapy make this disease a still threatening tumor. Genetic asset, environmental stress, dietary habit and infections caused by Helicobacter pylori (H. pylori) are the major causes concurring to GC initiation. A common mechanism is induction of radicals resulting in gastric mucosal injury. A regular food intake of antioxidant and radical scavenging agents has been proposed to exert protection against tumorigenesis...
October 7, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26380570/current-opinions-on-stress-related-mucosal-disease-prevention-in-canadian-pediatric-intensive-care-units
#20
Jérôme Ouellet, Dennis Bailey, Marie-Ève Samson
OBJECTIVE: To describe current opinions about stress-related mucosal disease (SRMD) prevention in Canadian pediatric intensive care units (PICUs). METHODS: A 22-question survey covering several aspects of SRMD was sent to all identified PICU attendings in Canada. RESULTS: Sixty-eight percent of identified attendings completed the questionnaire. Thirty-eight percent were based in Quebec, 31% in Alberta, and 31% from other provinces. Most attendings (78%) had worked in a PICU for 6 years or more...
July 2015: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
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