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Stress related mucosal disease

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https://www.readbyqxmd.com/read/28338023/implant-maintenance-treatment-and-peri-implant-health
#1
COMMENT
Mark-Steven Howe
Data sourcesMedline (PubMed), Embase, Cochrane Central Register of Controlled Trials and Cochrane Oral Health Group Trials Register databases and a manual search of the Journal of Dental Research, Journal of Clinical Periodontology, Journal of Periodontology and the International Journal of Periodontics and Restorative Dentistry from January 2014 to February 2015.Study selectionProspective, retrospective, randomised or not, case-controlled or case series trials showing the incidence or recurrence of peri-implant disease plus or minus PIMT over more than six months...
March 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28320982/comparison-of-three-acute-stress-models-for-simulating-the-pathophysiology-of-stress-related-mucosal-disease
#2
Bhagawati Saxena, Sanjay Singh
Stress-related mucosal disease (SRMD) is highly prevalent in intensive care patients leading to increasing treatment cost and mortality. SRMD is a disease elusive of ideal treatment. Evaluation of drugs is very pertinent for the efficient and safe treatment of SRMD. It relies mainly on in vivo screening models. There are various stress models, and till date, none of them is validated for simulating the SRMD pathophysiology. The present study aims to choose the best model, which reproduce pathophysiology of SRMD, among previously established stress models...
March 19, 2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/28259289/proton-pump-inhibitors-in-cancer-patients-how-useful-they-are-a-review-of-the-most-common-indications-for-their-use
#3
REVIEW
Gianmauro Numico, Vittorio Fusco, Pierfrancesco Franco, Fausto Roila
Proton-Pump Inhibitors (PPIs) are commonly prescribed in the general population and in cancer patients. A supposed role in the prevention of gastric mucosal damage apparently justify their use in patients undergoing cytotoxic chemotherapy, steroids and radiotherapy on the gastro-duodenal region. They are frequently given also to patients admitted to Intensive Care Units, for the prevention of stress-related gastric ulcers. The evidence about these use of gastroprotection is reviewed. In the majority of the cases the prescription of PPIs is not justified...
March 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28257879/enzymatically-synthesized-glycogen-inhibits-colitis-through-decreasing-oxidative-stress
#4
Takakazu Mitani, Yasukiyo Yoshioka, Takashi Furuyashiki, Yoko Yamashita, Yasuhito Shirai, Hitoshi Ashida
Inflammatory bowel diseases are a group of chronic inflammation conditions of the gastrointestinal tract. Disruption of the mucosal immune response causes accumulation of oxidative stress, resulting in the induction of inflammatory bowel disease. In this study, we investigated the effect of enzymatically synthesized glycogen (ESG), which is produced from starch, on dextran sulfate sodium (DSS)- and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in C57BL/6 mice. Oral administration of ESG suppressed DSS- and TNBS-induced shortening of large intestine in female mice and significant decreased DSS-induced oxidative stress and TNBS-induced pro-inflammatory cytokine expression in the large intestine...
February 28, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28251844/overview-of-pathophysiological-features-of-gerd
#5
Paolo Usai Satta, Francesco Oppia, Francesco Cabras
Gastro-esophageal reflux disease (GERD) is a very prevalent condition and has a high impact on the quality of life. Nevertheless, pathophysiology is complex and multi-factorial. Several mechanisms have been proposed: decreased salivation, decreased lower esophageal sphincter pressure resting tone, presence of hiatal hernia, increased number of transient lower esophageal sphincter relaxations, increased acid, and pepsin secretion, duodeno-gastro-esophageal reflux of bile acids and trypsin. Other factors contributing to the pathophysiology of GERD include poor esophageal clearance, delayed gastric emptying and impaired mucosal defensive factors...
March 1, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28240194/brain-and-gut-crf-signaling-biological-actions-and-role-in-the-gastrointestinal-tract
#6
Yvette Taché, Mulugeta Million, Muriel Larauche, Pu-Qing Yuan
Corticotropin-releasing factor (CRF) signaling pathways coordinate the behavioral, endocrine, autonomic and visceral responses to stress. Convergent anatomical, molecular, pharmacological and functional experimental evidence supports an important role of brain CRF receptor signaling in stress-related alterations of gastrointestinal functions. These include the inhibition of gastric acid secretion and gastro-small intestinal transit, the stimulation of colonic enteric nervous system and secretory-motor function, enhanced intestinal permeability, and visceral hypersensitivity...
February 23, 2017: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/28202416/microarray-analysis-of-macrophage-response-to-infection-with-streptococcus-oralis-reveals-the-immunosuppressive-effect-of-hydrogen-peroxide
#7
Hitomi Matsushima, Yutaro Kumagai, Alexis Vandenbon, Hideo Kataoka, Miki Kadena, Haruka Fukamachi, Takafumi Arimoto, Hirobumi Morisaki, Nagatoshi Fujiwara, Nobuo Okahashi, Hirotaka Kuwata
Oral streptococci including mitis group streptococci are commensal residents and are also the first to colonize the oral cavity. However, various species of these oral streptococci have the potential to invade the host and occasionally lead to severe infectious disease such as cardiovascular diseases. Oral streptococci have close interactions with the host immune system including macrophages at the oral mucosal surface. One notable common trait of oral streptococcus including Streptococcus oralis (S. oralis) is the production of hydrogen peroxide (H2O2)...
April 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28190393/significance-of-cholinergic-and-peptidergic-nerves-in-stress-induced-ulcer-and-malt-lymphoma-formation
#8
Masahiko Nakamura, Anders Øverby, Akina Uehara, Masaya Oda, Shinichi Takahashi, Somay Y Murayama, Hidenori Matsui
Backgound: The role of enteric nerves has previously been demonstrated in the formation of several gastric diseases. In the present review, the significance of the cholinergic nerves in stress-induced ulcer formation as well as the importance of substance P in the formation of gastric MALT lymphoma is discussed. METHODS: The stress-induced ulcer was induced by the plaster bandage methods in rats. The gastric MALT lymphoma was formed by the peroral infection of gastric mucosal homogenate of the infected mouse in C57BL/6 mice...
February 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28063885/identification-of-nf-%C3%AE%C2%BAb-related-genes-in-channel-catfish-and-their-expression-profiles-in-mucosal-tissues-after-columnaris-bacterial-infection
#9
Xiaozhu Wang, Shikai Liu, Yujia Yang, Qiang Fu, Ash Abebe, Zhanjiang Liu
Interactions of NF-κB family, IκB family and IKK complex are the key components of NF-κB pathway that is essential for many biological processes including innate and adaptive immunity, inflammation and stress responses. In spite of their importance, systematic analysis of these genes in fish has been lacking. Here we report a systematic study of the NF-κB related genes in channel catfish. Five NF-κB family genes, five IκB family genes and three IKK complex genes were identified in the channel catfish genome...
January 4, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28028951/increased-expression-of-tlr4-and-tlr7-but-not-prolactin-mrna-by-peripheral-blood-monocytes-in-active-celiac-disease
#10
Iva Brynychova, Iva Hoffmanova, Milos Dvorak, Pavlina Dankova
BACKGROUND: Celiac disease (CD) is an organ-specific autoimmune disease, and both adaptive and innate immunity are involved in its development. OBJECTIVES: The aim of the study was to determine whether the markers of intestinal mucosal inflammation in CD can be detected in peripheral blood monocytes (PBMs), and whether the immune properties of PBMs change as the clinical signs and symptoms of CD improve after the introduction of a gluten-free diet (GFD). The focus was on changes in mRNA expression of selected toll-like receptors (TLR2, TLR4, TLR7), stress cytokine prolactin (PRL), and proand anti-inflammatory cytokines (TNF-α, IL-6, IL-12, IL-10) in PBMs...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27733718/prevalence-of-deleterious-oral-habits-and-oral-mucosal-lesions-among-fishermen-population-of-mahe-south-india
#11
Ksa Anzil, J Mathews, A G Sai, M Kiran, S Kevin, S Sunith
INTRODUCTION: Fishing is an occupation associated with uneven diet, strain, drunkenness, tobacco use, and deleterious habits. The physical state of laborers on a large scale will also be influenced by conditions at their work site. Oral mucosal lesions can occur as a result of infections, local shock or infuriation, systemic diseases, and uncontrolled usage of tobacco, betel quid, and alcohol. The aim of the present study is to assess the prevalence of deleterious oral habits and oral mucosal lesions among fishermen population of Mahe, South India...
September 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27635116/protective-effect-of-amphipterygium-adstringens-extract-on-dextran-sulphate-sodium-induced-ulcerative-colitis-in-mice
#12
Mario Rodriguez-Canales, Ruben Jimenez-Rivas, Maria Margarita Canales-Martinez, Ana Judith Garcia-Lopez, Nelly Rivera-Yañez, Oscar Nieto-Yañez, Yadira Ledesma-Soto, Luvia Enid Sanchez-Torres, Miriam Rodriguez-Sosa, Luis Ignacio Terrazas, Marco Aurelio Rodriguez-Monroy
Amphipterygium adstringens is an endemic species in Mexico commonly known as "cuachalalate." Healers to treat gastritis, gastric ulcers, and gastrointestinal cancer have traditionally used the bark. We investigated the effects of alcoholic extract of A. adstringens (AaEE) in DSS-induced colitis in mice. The protective effect of AaEE was determined at 200 mg/kg by oral gavage for 10 days. We determine the effect of AaEE on clinical features (disease activity index), antioxidants, anti-inflammatory, and immunomodulatory activities in relation to the activity of SOD, CAT, and GPx, levels of proinflammatory cytokines, and changes both macroscopic and microscopic of the colonic mucosa...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27452660/antiinflammatory-and-immunomodulatory-activity-of-an-ethanolic-extract-from-the-stem-bark-of-terminalia-catappa-l-combretaceae-in-vitro-and-in-vivo-evidences
#13
Oyindamola O Abiodun, Alba Rodríguez-Nogales, Francesca Algieri, Ana Maria Gomez-Caravaca, Antonio Segura-Carretero, M Pilar Utrilla, M Elena Rodriguez-Cabezas, Julio Galvez
ETHNOPHARMOCOLOGICAL RELEVANCE: Terminalia catappa Linn (Combretaceae) is a medicinal plant with anti-inflammatory, anti-diarrhoeal and antioxidant properties, frequently found in tropical regions. Considering its characteristics, it could be useful for the treatment of inflammatory bowel disease, which is associated with inflammation, oxidative stress and an immune dysfunction. Thus this study evaluates the immunomodulatory properties and the intestinal anti-inflammatory effect of an ethanolic extract of the stem bark of T...
November 4, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27446898/study-protocol-on-hormonal-mediation-of-exercise-on-cognition-stress-and-immunity-pro-hmecsi-effects-of-different-exercise-programmes-in-institutionalized-elders
#14
Ana Maria Teixeira, José Pedro Ferreira, Eef Hogervorst, Margarida Ferreira Braga, Stephan Bandelow, Luís Rama, António Figueiredo, Maria João Campos, Guilherme Eustáquio Furtado, Matheus Uba Chupel, Filipa Martins Pedrosa
Physical activity (PA) in elders has been shown to have positive effects on a plethora of chronic diseases and to improve immunity, mental health, and cognition. Chronic stress has also been shown to have immuno-suppressive effects and to accelerate immunosenescence. Exercise could be a significant factor in ameliorating the deleterious effects of chronic stress, but variables such as the type, intensity, and frequency of exercise that should be performed in order to effectively reduce the stress burden need to be defined clearly...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27404394/systems-toxicology-assessment-of-the-biological-impact-of-a-candidate-modified-risk-tobacco-product-on-human-organotypic-oral-epithelial-cultures
#15
Filippo Zanetti, Alain Sewer, Carole Mathis, Anita R Iskandar, Radina Kostadinova, Walter K Schlage, Patrice Leroy, Shoaib Majeed, Emmanuel Guedj, Keyur Trivedi, Florian Martin, Ashraf Elamin, Céline Merg, Nikolai V Ivanov, Stefan Frentzel, Manuel C Peitsch, Julia Hoeng
Cigarette smoke (CS) has been reported to increase predisposition to oral cancer and is also recognized as a risk factor for many conditions including periodontal diseases, gingivitis, and other benign mucosal disorders. Smoking cessation remains the most effective approach for minimizing the risk of smoking-related diseases. However, reduction of harmful constituents by heating rather than combusting tobacco, without modifying the amount of nicotine, is a promising new paradigm in harm reduction. In this study, we compared effects of exposure to aerosol derived from a candidate modified risk tobacco product, the tobacco heating system (THS) 2...
August 15, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27279158/-irritable-bowel-syndrome-emotion-regulation-and-gut-microbiota
#16
Shin Fukudo
Irritable bowel syndrome (IBS) is defined as a representative functional gastrointestinal disorder which is characterized by chronic or recurrent abdominal pain and/or abdominal discomfort associated with abnormal bowel movement. Gut microbiota are related to the pathophysiology of IBS. In the field of IBS, post-infectious etiology, stress-induced alteration of microbiota, increased mucosal permeability, bacterial overgrowth, disease-specific microbiota, microbial products, and brain-gut interactions are being investigated...
June 2016: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/27274339/association-between-serotonin-transporter-gene-polymorphism-and-recurrent-aphthous-stomatitis
#17
Aastha Manchanda, Asha R Iyengar, Seema Patil
BACKGROUND: Anxiety-related traits have been attributed to sequence variability in the genes coding for serotonin transmission in  the brain. Two alleles, termed long (L) and short (S) differing by 44 base pairs, are found in a polymorphism identified in the promoter region of serotonin transporter gene. The presence of the short allele  and SS and LS genotypes is found to be associated with the reduced expression of this gene decreasing the uptake of serotonin in the brain leading to various anxiety-related traits...
May 2016: Dental Research Journal
https://www.readbyqxmd.com/read/27187687/a-nomogram-for-predicting-complications-in-patients-with-solid-tumours-and-seemingly-stable-febrile-neutropenia
#18
Paula Jiménez Fonseca, Alberto Carmona-Bayonas, Ignacio Matos García, Rosana Marcos, Eduardo Castañón, Maite Antonio, Carme Font, Mercè Biosca, Ana Blasco, Rebeca Lozano, Avinash Ramchandani, Carmen Beato, Eva Martínez de Castro, Javier Espinosa, Jerónimo Martínez-García, Ismael Ghanem, Jorge Hernando Cubero, Isabel Aragón Manrique, Francisco García Navalón, Elena Sevillano, Aránzazu Manzano, Juan Virizuela, Marcelo Garrido, Rebeca Mondéjar, María Ángeles Arcusa, Yaiza Bonilla, Quionia Pérez, Elena Gallardo, Maria Del Carmen Soriano, Mercè Cardona, Fernando Sánchez Lasheras, Juan Jesús Cruz, Francisco Ayala
BACKGROUND: We sought to develop and externally validate a nomogram and web-based calculator to individually predict the development of serious complications in seemingly stable adult patients with solid tumours and episodes of febrile neutropenia (FN). PATIENTS AND METHODS: The data from the FINITE study (n=1133) and University of Salamanca Hospital (USH) FN registry (n=296) were used to develop and validate this tool. The main eligibility criterion was the presence of apparent clinical stability, defined as events without acute organ dysfunction, abnormal vital signs, or major infections...
May 24, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27133563/saccharomyces-cerevisiae-ufmg-a-905-treatment-reduces-intestinal-damage-in-a-murine-model-of-irinotecan-induced-mucositis
#19
R W Bastos, S H S P Pedroso, A T Vieira, L M C Moreira, C S França, C T Cartelle, R M E Arantes, S V Generoso, V N Cardoso, M J Neves, J R Nicoli, F S Martins
Indigenous microbiota plays a crucial role in the development of several intestinal diseases, including mucositis. Gastrointestinal mucositis is a major and serious side effect of cancer therapy, and there is no effective therapy for this clinical condition. However, some probiotics have been shown to attenuate such conditions. To evaluate the effects of Saccharomyces cerevisiae UFMG A-905 (Sc-905), a potential probiotic yeast, we investigated whether pre- or post-treatment with viable or inactivated Sc-905 could prevent weight loss and intestinal lesions, and maintain integrity of the mucosal barrier in a mucositis model induced by irinotecan in mice...
September 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27087247/altered-mucosal-microbiome-diversity-and-disease-severity-in-sj%C3%A3-gren-syndrome
#20
Cintia S de Paiva, Dan B Jones, Michael E Stern, Fang Bian, Quianta L Moore, Shani Corbiere, Charles F Streckfus, Diane S Hutchinson, Nadim J Ajami, Joseph F Petrosino, Stephen C Pflugfelder
There is mounting evidence that the microbiome has potent immunoregulatory functions. We assessed the effects of intestinal dysbiosis in a model of Sjögren syndrome (SS) by subjecting mice to desiccating stress (DS) and antibiotics (ABX). We characterized the conjunctival, tongue and fecal microbiome profiles of patients with SS. Severity of ocular surface and systemic disease was graded. 16S ribosomal RNA gene sequencing characterized the microbiota. ABX + DS mice had a significantly worse dry eye phenotype compared to controls, a decrease in Clostridium and an increase in Enterobacter, Escherichia/Shigella, and Pseudomonas in stool after ABX + DS for 10 days...
2016: Scientific Reports
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