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https://www.readbyqxmd.com/read/28227477/predictive-models-for-diffuse-low-grade-glioma-patients-under-chemotherapy
#1
Meriem Ben Abdallah, Marie Blonski, Sophie Wantz-Mezieres, Yann Gaudeau, Luc Taillandier, Jean-Marie Moureaux, Meriem Ben Abdallah, Marie Blonski, Sophie Wantz-Mezieres, Yann Gaudeau, Luc Taillandier, Jean-Marie Moureaux, Luc Taillandier, Jean-Marie Moureaux, Marie Blonski, Yann Gaudeau, Sophie Wantz-Mezieres, Meriem Ben Abdallah
Diffuse low-grade gliomas are rare primitive cerebral tumours of adults. These tumors progress continuously over time and then turn to a higher grade of malignancy associated with neurological disability, leading ultimately to death. Tumour size is one of the most important prognostic factors. Thus, it is of great importance to be able to assess the volume of the tumor during the patients' monitoring. MRI is nowadays the recommended modality to achieve this. Furthermore, if surgery remains the first option for diffuse low-grade gliomas, chemotherapy is increasingly used (before or after a possible surgery)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28221962/modeling-the-effect-of-temperature-and-water-activity-on-the-thermal-resistance-of-salmonella-enteritidis-pt-30-in-wheat-flour
#2
Danielle F Smith, Ian M Hildebrandt, Kaitlyn E Casulli, Kirk D Dolan, Bradley P Marks
Salmonella continues to be a problem associated with low-moisture foods, particularly given enhanced thermal resistance at lower water activity (aw). However, there is a scarcity of thermal inactivation models accounting for the effect of aw. The objective of this study was to test multiple secondary models for the effect of product (wheat flour) aw on Salmonella enterica Enteritidis phage type 30 thermal resistance. A full-factorial experimental design included three temperatures (75, 80, and 85°C) and four aw values (~0...
December 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28214596/early-non-response-to-certolizumab-pegol-in-rheumatoid-arthritis-predicts-treatment-failure-at-one-year-data-from-a-randomised-phase-iii-clinical-trial
#3
Francis Berenbaum, Thao Pham, Pascal Claudepierre, Thibault de Chalus, Jean-Michel Joubert, Carine Saadoun, Lionel Riou França, Bruno Fautrel
OBJECTIVES: To compare different early clinical criteria of non-response determined at three months as predictors of clinical failure at one year in patients with rheumatoid arthritis starting therapy with certolizumab pegol. METHODS: Data were derived from a randomised Phase III clinical trial in patients with rheumatoid arthritis who failed to respond to methotrexate monotherapy. Patients included in this post-hoc analysis were treated with certolizumab pegol (400mg qd reduced to 200mg qd after one month) and with methotrexate...
February 15, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28208251/rapid-method-development-in-hydrophilic-interaction-liquid-chromatography-for-pharmaceutical-analysis-using-a-combination-of-quantitative-structure-retention-relationships-and-design-of-experiments
#4
Maryam Taraji, Paul R Haddad, Ruth I J Amos, Mohammad Talebi, Roman Szucs, John W Dolan, Chris A Pohl
A design-of-experiment (DoE) model was developed, able to describe the retention times of a mixture of pharmaceutical compounds in hydrophilic interaction liquid chromatography (HILIC) under all possible combinations of acetonitrile content, salt concentration, and mobile-phase pH with R(2) > 0.95. Further, a quantitative structure-retention relationship (QSRR) model was developed to predict retention times for new analytes, based only on their chemical structures, with a root-mean-square error of prediction (RMSEP) as low as 0...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28205132/the-city-infant-faces-database-a-validated-set-of-infant-facial-expressions
#5
Rebecca Webb, Susan Ayers, Ansgar Endress
Adults need to be able to process infants' emotional expressions accurately to respond appropriately and care for infants. However, research on processing of the emotional expressions of infant faces is hampered by the lack of validated stimuli. Although many sets of photographs of adult faces are available to researchers, there are no corresponding sets of photographs of infant faces. We therefore developed and validated a database of infant faces, which is available via e-mail request. Parents were recruited via social media and asked to send photographs of their infant (0-12 months of age) showing positive, negative, and neutral facial expressions...
February 15, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28197406/long-term-formation-of-aggressive-bony-lesions-in-dogs-with-mid-diaphyseal-fractures-stabilized-with-metallic-plates-incidence-in-a-tertiary-referral-hospital-population
#6
Robert S Gilley, Elizabeth Hiebert, Kemba Clapp, Lara Bartl-Wilson, Michael Nappier, Stephen Werre, Katherine Barnes
The incidence of complications secondary to fracture stabilization, particularly osteolytic lesions and bony tumor formation, has long been difficult to evaluate. The objective of this study was to describe the long-term incidence of aggressive bony changes developing in dogs with long bone diaphyseal fractures stabilized by metallic bone plates compared to a breed-, sex-, and age-matched control group. The medical records of a tertiary referral center were retrospectively reviewed for dogs that matched each respective criterion...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28196917/validation-of-milliflex%C3%A2-quantum-for-bioburden-testing-of-pharmaceutical-products
#7
Oliver Gordon, Marcel Goverde, Alexandra Staerk, David Roesti
This article reports the validation strategy used to demonstrate that the Milliflex® Quantum yielded non-inferior results to the traditional bioburden method. It was validated according to USP <1223>, Ph. Eur. 5.1.6 and PDA Technical Report No. 33 and comprised the validation parameters Robustness, Ruggedness, Repeatability, Specificity, Limit of Detection and Quantification, Accuracy, Precision, Linearity, Range and Equivalence in Routine Operation. For the validation, a combination of pharmacopeial ATCC strains as well as a broad selection of in-house isolates was used...
February 14, 2017: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/28196464/sparse-kernel-canonical-correlation-analysis-for-discovery-of-nonlinear-interactions-in-high-dimensional-data
#8
Kosuke Yoshida, Junichiro Yoshimoto, Kenji Doya
BACKGROUND: Advance in high-throughput technologies in genomics, transcriptomics, and metabolomics has created demand for bioinformatics tools to integrate high-dimensional data from different sources. Canonical correlation analysis (CCA) is a statistical tool for finding linear associations between different types of information. Previous extensions of CCA used to capture nonlinear associations, such as kernel CCA, did not allow feature selection or capturing of multiple canonical components...
February 14, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28193740/development-of-delayed-hemolytic-anemia-after-treatment-with-oral-artemether-lumefantrine-in-two-patients-with-severe-falciparum-malaria
#9
Yasuhiro Tsuchido, Fukumi Nakamura-Uchiyama, Kasumi Toyoda, Moritoshi Iwagami, Kentaro Tochitani, Koh Shinohara, Naokuni Hishiya, Taku Ogawa, Kenji Uno, Kei Kasahara, Yukiteru Ouji, Shigeyuki Kano, Keiichi Mikasa, Tsunehiro Shimizu, Masahide Yoshikawa, Haruhiko Maruyama
Recently, reports of delayed hemolytic anemia after treatment with artemisinin and its derivatives have emerged. Here we report two cases of delayed hemolytic anemia in a patient with severe falciparum malaria after treatment with oral artemether-lumefantrine (AL). The first patient, a 20-year-old Japanese male student, was diagnosed with falciparum malaria and was administered AL. As having a high parasitemia rate (20.6%) was the only severe malaria criterion met in this case and his general condition was stable, we continued with AL treatment...
February 13, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28192639/a-deep-learning-based-strategy-for-identifying-and-associating-mitotic-activity-with-gene-expression-derived-risk-categories-in-estrogen-receptor-positive-breast-cancers
#10
David Romo-Bucheli, Andrew Janowczyk, Hannah Gilmore, Eduardo Romero, Anant Madabhushi
The treatment and management of early stage estrogen receptor positive (ER+) breast cancer is hindered by the difficulty in identifying patients who require adjuvant chemotherapy in contrast to those that will respond to hormonal therapy. To distinguish between the more and less aggressive breast tumors, which is a fundamental criterion for the selection of an appropriate treatment plan, Oncotype DX (ODX) and other gene expression tests are typically employed. While informative, these gene expression tests are expensive, tissue destructive, and require specialized facilities...
February 13, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28192533/improving-medication-safety-development-and-impact-of-a-multivariate-model-based-strategy-to-target-high-risk-patients
#11
Tri-Long Nguyen, Géraldine Leguelinel-Blache, Jean-Marie Kinowski, Clarisse Roux-Marson, Marion Rougier, Jessica Spence, Yannick Le Manach, Paul Landais
BACKGROUND: Preventive strategies to reduce clinically significant medication errors (MEs), such as medication review, are often limited by human resources. Identifying high-risk patients to allow for appropriate resource allocation is of the utmost importance. To this end, we developed a predictive model to identify high-risk patients and assessed its impact on clinical decision-making. METHODS: From March 1st to April 31st 2014, we conducted a prospective cohort study on adult inpatients of a 1,644-bed University Hospital Centre...
2017: PloS One
https://www.readbyqxmd.com/read/28187026/an-algorithmic-approach-to-the-suspected-septic-wrist
#12
Jeffrey R Claiborne, Leslie G Branch, Michael Reynolds, Anthony J Defranzo
An acutely painful, erythematous wrist can be due to a variety of pathologic processes, including crystalline arthropathy, infection, trauma, osteoarthritis, and systemic disease. The broad differential diagnosis of the inflamed wrist and nonspecific clinical findings make accurate diagnosis challenging. There is no published clinical or laboratory criterion that reliably differentiates septic wrist arthritis from a sterile inflammatory arthropathy. For septic joint patients, long-term results are notably poorer in patients with a delay in treatment, therefore establishing evidenced-based guidelines deserves attention...
February 10, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28182664/improving-our-forecasts-for-trachoma-elimination-what-else-do-we-need-to-know
#13
Amy Pinsent, Manoj Gambhir
The World Health Organization (WHO) has targeted trachoma for elimination as a public health concern by 2020. Mathematical modelling is used for a range of infectious diseases to assess the impact of different intervention strategies on the prevalence of infection or disease. Here we evaluate the performance of four different mechanistic mathematical models that could all realistically represent trachoma transmission. We fit the four different mechanistic models of trachoma transmission to cross-sectional age-specific Polymerase Chain Reaction (PCR) and Trachomatous inflammation, follicular (TF) prevalence data...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28178998/tissue-perfusion-modelling-in-optical-coherence-tomography
#14
Petra Stohanzlova, Radim Kolar
BACKGROUND: Optical coherence tomography (OCT) is a well established imaging technique with different applications in preclinical research and clinical practice. The main potential for its application lies in the possibility of noninvasively performing "optical biopsy". Nevertheless, functional OCT imaging is also developing, in which perfusion imaging is an important approach in tissue function study. In spite of its great potential in preclinical research, advanced perfusion imaging using OCT has not been studied...
February 8, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28178045/assessment-of-transvaginal-ultrasound-cervical-length-image-quality
#15
Rupsa C Boelig, Helen Feltovich, Jean Lea Spitz, Gregory Toland, Vincenzo Berghella, Jay D Iams
OBJECTIVE: To use data from the Cervical Length Education and Review program to evaluate the quality of transvaginal cervical length ultrasonography by trained imagers (ie, ultrasonographers, radiologists, perinatologists). METHODS: This is a retrospective observational study of data from the Cervical Length Education and Review program. Candidates underwent an online lecture series, examination, and submitted a batch of images for review. For a candidate's batch of images to pass, all images must meet at least seven of the nine criteria assessed, the overall batch score needs to be 80% or greater, correct caliper placement must be met for all images, and the same criterion cannot be consistently missed...
March 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28167376/identifying-elder-abuse-neglect-among-family-caregiving-dyads-a-cross-sectional-study-of-psychometric-properties-of-the-qualcare-scale
#16
Carolyn E Z Pickering, Kimberly Ridenour, Zachary Salaysay, David Reyes-Gastelum, Steven J Pierce
BACKGROUND/OBJECTIVES: Universal screening for elder abuse and neglect is a current controversy in geriatrics, fueled by the lack of evidence on valid and reliable instruments. Since each U.S. State and many other countries have their own legal definitions of what constitutes elder abuse and neglect, this further complicates instrument development and clinical assessment. The purpose of this paper is to present data on the sensitivity and specificity of the QualCare Scale, an instrument with utility in detecting clinically significant elder abuse and neglect among older adults receiving care at home...
January 30, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28161396/the-method-used-to-set-the-pass-mark-in-an-objective-structured-clinical-examination-defines-the-performance-of-candidates-for-certification-as-rheumatologists
#17
Virginia Pascual-Ramos, Gabriel Medrano-Ramírez, Eunice Solís-Vallejo, Ana Guilaisne Bernard-Medina, Diana Elsa Flores-Alvarado, Margarita Portela-Hernández, María Del Rocío Maldonado-Velázquez, Luis Javier Jara-Quezada, Luis Manuel Amezcua-Guerra, Judith López-Zepeda, Miguel Ángel Saavedra, César Alejandro Arce-Salinas
BACKGROUND: The Mexican Accreditation Council for Rheumatology certifies trainees (TR) on an annual basis using both a multiple-choice question (MCQ) test and an objective structured clinical examination (OSCE). For 2013 and 2014, the OSCE pass mark (PM) was set by criterion referencing as ≥6 (CPM), whereas overall rating of borderline performance method (BPM) was added for 2015 and 2016 accreditations. We compared OSCE TR performance according to CPM and BPM, and examined whether correlations between MCQ and OSCE were affected by PM...
February 1, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28152403/application-of-experimental-design-and-derivative-spectrophotometry-methods-in-optimization-and-analysis-of-biosorption-of-binary-mixtures-of-basic-dyes-from-aqueous-solutions
#18
Arash Asfaram, Mehrorang Ghaedi, Gholam Reza Ghezelbash, Francesco Pepe
Simultaneous biosorption of malachite green (MG) and crystal violet (CV) on biosorbent Yarrowia lipolytica ISF7 was studied. An appropriate derivative spectrophotometry technique was used to evaluate the concentration of each dye in binary solutions, despite significant interferences in visible light absorbances. The effects of pH, temperature, growth time, initial MG and CV concentration in batch experiments were assessed using Design of Experiment (DOE) according to central composite second order response surface methodology (RSM)...
January 30, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28146678/measuring-sustained-attention-and-perceived-workload
#19
Cynthia Laurie-Rose, Lori M Curtindale, Meredith Frey
OBJECTIVE: We examined the effects of spatial uncertainty, field dependence/independence (FD/I), and sex on vigilance performance and perceived workload in elementary school children. BACKGROUND: Building on previous work in which children demonstrated their ability to evaluate workload, we tested whether spatial-uncertainty manipulations in a vigilance task would elicit in children the same deleterious effects on performance and workload as it does with adults...
February 2017: Human Factors
https://www.readbyqxmd.com/read/28139440/the-parasternal-short-axis-view-improves-diagnostic-accuracy-for-inferior-sinus-venosus-type-of-atrial-septal-defects-by-transthoracic-echocardiography
#20
Brian S Snarr, Michael Y Liu, Jeremy C Zuckerberg, Christine B Falkensammer, Sumekala Nadaraj, Danielle Burstein, Deborah Ho, Monique A Gardner, Arene Butto, Stanford G Ewing, Natesa G Pandian, Anirban Banerjee
BACKGROUND: Sinus venosus defects (SVD) of the inferior vena cava (IVC) type, or inferior SVDs, are an uncommon form of atrial communication located outside the confines of the fossa ovalis and involve override of the IVC. Despite numerous studies describing the anatomical and echocardiographic features of the inferior SVD, distinguishing this defect from a large secundum atrial septal defect (ASD) by echocardiography is often challenging. Accurate diagnosis of an inferior SVD and correct differentiation from a secundum ASD is essential for appropriate presurgical planning...
January 27, 2017: Journal of the American Society of Echocardiography
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