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Appropriateness criterion

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https://www.readbyqxmd.com/read/27913328/subharmonic-response-of-polymer-contrast-agents-based-on-the-empirical-mode-decomposition
#1
Rintaro Hayashi, John S Allen, Parag V Chitnis, Jonathan Mamou, Jeffrey A Ketterling
The subharmonic threshold for ultrasound contrast agents has been defined as a 20-25 dB difference between the fundamental and subharmonic (2/1) spectral components of the backscatter signal. However, this Fourier-based criterion assumes a linear time-invariant signal. A more appropriate criterion for short cycle and frequency-modulated waveforms is proposed with an adaptive signal-processing approach based on the empirical mode decomposition (EMD) method. The signal is decomposed into an orthogonal basis known as intrinsic mode functions (IMFs) and a subharmonic threshold is defined with respect to the energy ratio of the subharmonic IMF component to that of the incident signal...
December 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27903921/a-two-pool-model-to-describe-the-ivim-cerebral-perfusion
#2
Gabrielle Fournet, Jing-Rebecca Li, Alex M Cerjanic, Bradley P Sutton, Luisa Ciobanu, Denis Le Bihan
IntraVoxel Incoherent Motion (IVIM) is a magnetic resonance imaging (MRI) technique capable of measuring perfusion-related parameters. In this manuscript, we show that the mono-exponential model commonly used to process IVIM data might be challenged, especially at short diffusion times. Eleven rat datasets were acquired at 7T using a diffusion-weighted pulsed gradient spin echo sequence with b-values ranging from 7 to 2500 s/mm(2) at three diffusion times. The IVIM signals, obtained by removing the diffusion component from the raw MR signal, were fitted to the standard mono-exponential model, a bi-exponential model and the Kennan model...
November 30, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27896750/inference-method-for-developing-mathematical-models-of-cell-signaling-pathways-using-proteomic-datasets
#3
Tianhai Tian, Jiangning Song
The progress in proteomics technologies has led to a rapid accumulation of large-scale proteomic datasets in recent years, which provides an unprecedented opportunity and valuable resources to understand how living organisms perform necessary functions at systems levels. This work presents a computational method for designing mathematical models based on proteomic datasets. Using the mitogen-activated protein (MAP) kinase pathway as the test system, we first develop a mathematical model including the cytosolic and nuclear subsystems...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27888708/prognostic-value-of-tumor-infiltrating-lymphocytes-for-patients-with-head-and-neck-squamous-cell-carcinoma
#4
Qiaoshi Xu, Chong Wang, Xiaohong Yuan, Zhien Feng, Zhengxue Han
BACKGROUND: The prognostic value of tumor-infiltrating lymphocytes (TILs) in head and neck squamous cell carcinoma (HNSCC) remains controversial. Additionally, there is no standardized approach or cutoff value for evaluating TIL levels. The aim of this study was to establish a feasible method and criterion to assess TIL levels for future clinical practice and research use and to explore the relationship between TIL levels and prognosis. PATIENTS AND METHODS: This retrospective cohort study reviewed the records and pathological sections of 202 patients with HNSCC who were surgically treated at Beijing Stomatological Hospital, Capital Medical University, from January 1998 to January 2011...
November 23, 2016: Translational Oncology
https://www.readbyqxmd.com/read/27876279/non-fragile-sampled-data-robust-synchronization-of-uncertain-delayed-chaotic-lurie-systems-with-randomly-occurring-controller-gain-fluctuation
#5
Kaibo Shi, Yuanyan Tang, Xinzhi Liu, Shouming Zhong
This paper proposes a new non-fragile stochastic control method to investigate the robust sampled-data synchronization problem for uncertain chaotic Lurie systems (CLSs) with time-varying delays. The controller gain fluctuation and time-varying uncertain parameters are supposed to be random and satisfy certain Bernoulli distributed white noise sequences. Moreover, by choosing an appropriate Lyapunov-Krasovskii functional (LKF), which takes full advantage of the available information about the actual sampling pattern and the nonlinear condition, a novel synchronization criterion is developed for analyzing the corresponding synchronization error system...
November 19, 2016: ISA Transactions
https://www.readbyqxmd.com/read/27875798/parsimony-and-goodness-of-fit-in-multi-dimensional-nmr-inversion
#6
Petro Babak, Sergey Kryuchkov, Apostolos Kantzas
Multi-dimensional nuclear magnetic resonance (NMR) experiments are often used for study of molecular structure and dynamics of matter in core analysis and reservoir evaluation. Industrial applications of multi-dimensional NMR involve a high-dimensional measurement dataset with complicated correlation structure and require rapid and stable inversion algorithms from the time domain to the relaxation rate and/or diffusion domains. In practice, applying existing inverse algorithms with a large number of parameter values leads to an infinite number of solutions with a reasonable fit to the NMR data...
November 16, 2016: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/27870609/time-series-decomposition-into-oscillation-components-and-phase-estimation
#7
Takeru Matsuda, Fumiyasu Komaki
Many time series are naturally considered as a superposition of several oscillation components. For example, electroencephalogram (EEG) time series include oscillation components such as alpha, beta, and gamma. We propose a method for decomposing time series into such oscillation components using state-space models. Based on the concept of random frequency modulation, gaussian linear state-space models for oscillation components are developed. In this model, the frequency of an oscillator fluctuates by noise...
November 21, 2016: Neural Computation
https://www.readbyqxmd.com/read/27860137/estimating-the-development-rate-of-the-tomato-leaf-miner-tuta-absoluta-lepidoptera-gelechiidae-using-linear-and-non-linear-models
#8
Cesar A Marchioro, Flavia S Krechemer, Luis A Foerster
BACKGROUND: Tuta absoluta Meyrick (Lepidoptera: Gelechiidae) is native to South America and recently invaded European, African and Asian countries, where it is causing severe damage to tomato crops leading to an increase in the number of insecticide applications. This situation has prompted a demand for alternative pest management strategies aiming to control T. absoluta and concomitantly reduce insecticide applications. The development period for immature stages of T. absoluta at constant temperatures was modelled to select appropriate mathematical functions for simulating its development...
November 14, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27858395/low-back-pain-and-internet-infopollution
#9
Yavuz Samanci, Suat Erol Çelik
AIM: Increasing number of patients engages in health information seeking via the Internet. We aimed to determine the quality of information on Internet for treatment of three common neurosurgical conditions associated with lower back pain using the DISCERN® instrument. MATERIAL AND METHODS: The search phrases "lumbar disc herniation treatment", "lumbar spinal stenosis treatment" and "lumbar spondylolisthesis treatment" were searched in the Google® search engine using simple searching method...
October 14, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27847688/significant-glaucomatous-visual-field-progression-in-the-first-two-years-what-does-it-mean
#10
Andrew J Anderson
PURPOSE: It has been recommended that multiple visual field examinations be performed in the first 2 years after glaucoma diagnosis so that rapid visual field progression (≤-2 dB/year, using ordinary least squares regression over time of the summary index mean deviation [MD]) can be detected. Here I investigate how predictive a statistically significant regression slope is of truly rapid visual field progression. METHODS: I simulated visual field series (N = 100,000) spaced at 4 monthly intervals for the first 2 years...
November 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27846227/survival-analysis-of-single-large-5-cm-hepatocellular-carcinoma-patients-bclc-a-versus-b
#11
Yuri Cho, Dong Hyun Sinn, Su Jong Yu, Geum Youn Gwak, Ji Hoon Kim, Yang Jae Yoo, Dae Won Jun, Tae Yeob Kim, Hyo Young Lee, Eun Ju Cho, Jeong-Hoon Lee, Yoon Jun Kim, Jung-Hwan Yoon
BACKGROUND & AIMS: Single large (>5 cm) hepatocellular carcinoma (HCC) is classified as Barcelona Liver Clinic (BCLC) stage early stage (A). Yet, controversies exist whether single large HCC can be considered as early stage. We have analyzed long-term outcome to see which stage is appropriate for these patients. METHODS: From 2005 to 2006, 1,546 consecutive patients who were newly diagnosed as HCC (BCLC A or B) at four tertiary hospitals in Korea were analyzed...
2016: PloS One
https://www.readbyqxmd.com/read/27845858/atomoxetine-related-change-in-sluggish-cognitive-tempo-is-partially-independent-of-change-in-attention-deficit-hyperactivity-disorder-inattentive-symptoms
#12
Keith McBurnett, David Clemow, David Williams, Miguel Villodas, Linda Wietecha, Russell Barkley
OBJECTIVES: To evaluate effects of atomoxetine versus placebo on sluggish cognitive tempo (SCT) and determine factors affecting improvement of SCT in children with attention-deficit/hyperactivity disorder (ADHD) with dyslexia (ADHD+D) or dyslexia only. METHODS: This is a post hoc analysis of a 16-week placebo-controlled, double-blind randomized phase of a previously reported atomoxetine study in children aged 10-16 years with ADHD+D, Dyslexia-only, or ADHD-only (no placebo arm)...
November 15, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27831521/evaluating-the-validity-and-reliability-of-the-beliefs-about-medicines-questionnaire-in-low-income-spanish-speaking-patients-with-diabetes-in-the-united-states
#13
Krystal Jimenez, Cristina Vargas, Karla Garcia, Herlinda Guzman, Marco Angulo, John Billimek
PURPOSE: The purpose of this study was to examine the reliability and validity of a Spanish version of the Beliefs about Medicines Questionnaire (BMQ) as a measure to evaluate beliefs about medications and to differentiate adherent from nonadherent patients among low-income Latino patients with diabetes in the United States. METHODS: Seventy-three patients were administered the BMQ and surveyed for evidence of medication nonadherence. Internal consistency of the BMQ was assessed by Cronbach's alpha along with performing a confirmatory factor analysis...
November 9, 2016: Diabetes Educator
https://www.readbyqxmd.com/read/27829085/assessment-of-a-revised-management-strategy-for-patients-with-intraductal-papillary-mucinous-neoplasms-involving-the-main-pancreatic-duct
#14
Motokazu Sugimoto, Irmina A Elliott, Andrew H Nguyen, Stephen Kim, V Raman Muthusamy, Rabindra Watson, O Joe Hines, David W Dawson, Howard A Reber, Timothy R Donahue
Importance: According to the 2012 International Consensus Guidelines, the diagnostic criterion of intraductal papillary mucinous neoplasms (IPMNs) involving the main duct (MD IPMNs) or the main and branch ducts (mixed IPMNs) of the pancreatic system is a main pancreatic duct (MPD) diameter of 5.0 mm or greater on computed tomography (CT) or magnetic resonance imaging (MRI). However, surgical resection is recommended for patients with an MPD diameter of 10.0 mm or greater, which is characterized as a high-risk stigma...
November 9, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27821886/microcephaly-in-north-east-brazil-a-retrospective-study-on-neonates-born-between-2012-and-2015
#15
Juliana Sousa Soares de Araújo, Cláudio Teixeira Regis, Renata Grigório Silva Gomes, Thiago Ribeiro Tavares, Cícera Rocha Dos Santos, Patrícia Melo Assunção, Renata Valéria Nóbrega, Diana de Fátima Alves Pinto, Bruno Vinícius Dantas Bezerra, Sandra da Silva Mattos
OBJECTIVE: To assess the number of children born with microcephaly in the State of Paraíba, north-east Brazil. METHODS: We contacted 21 maternity centres belonging to a paediatric cardiology network, with access to information regarding more than 100 000 neonates born between 1 January 2012 and 31 December 2015. For 10% of these neonates, nurses were requested to retrieve head circumference measurements data from delivery-room books. We used three separate criteria to classify whether a neonate had microcephaly: (i) the Brazilian Ministry of Health proposed criterion: term neonates (gestational age ≥ 37 weeks) with a head circumference of less than 32 cm; (ii) Fenton curves: neonates with a head circumference of less than -3 standard deviation for age and gender; or (iii) the proportionality criterion: neonates with a head circumference of less than ((height/2))+10) ± 2...
November 1, 2016: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/27801359/bed-utilisation-in-an-irish-regional-paediatric-unit-a-cross-sectional-study-using-the-paediatric-appropriateness-evaluation-protocol-paep
#16
Coilín ÓhAiseadha, Mai Mannix, Jean Saunders, Roy K Philip
BACKGROUND: Increasing demand for limited healthcare resources raises questions about appropriate use of inpatient beds. In the first paediatric bed utilisation study at a regional university centre in Ireland, we conducted a cross-sectional study to audit the utilisation of inpatient beds at the Regional Paediatric Unit (RPU) in University Hospital Limerick (UHL), Limerick, Ireland and also examined hospital activity data, to make recommendations for optimal use of inpatient resources...
May 10, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/27800434/detection-of-food-hazards-in-foods-comparison-of-real-time-polymerase-chain-reaction-and-cultural-methods
#17
Paolo Bonilauri, Lia Bardasi, Roberto Leonelli, Mattia Ramini, Andrea Luppi, Federica Giacometti, Giuseppe Merialdi
Foodstuffs should not contain microorganisms or their toxins or metabolites in quantities suggesting an unacceptable risk for human health. The detection of food hazards in foods is performed by several tests that produce results dependent on the analytical method used: an analytical reference method, defined as standard, is associated with each microbiological criterion laid down in Regulation 2073/2005/EC, but, analytical methods other than the reference ones, in particular more rapid methods, could be used...
January 18, 2016: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/27793804/osteochondral-allograft-donor-host-matching-by-the-femoral-condyle-radius-of-curvature
#18
Derek T Bernstein, Craig A O'Neill, Ryan S Kim, Hugh L Jones, Philip C Noble, Joshua D Harris, Patrick C McCulloch
BACKGROUND: Conventional osteochondral allograft (OCA) matching, requiring orthotopic, size-matched condyles, and narrow surgical time windows often prohibit timely transplantation. HYPOTHESIS: The femoral condyle radius of curvature (RoC) is an appropriate, isolated criterion for donor-host matching in fresh OCAs, potentially enhancing matching efficiency when compared with conventional matching techniques. STUDY DESIGN: Descriptive laboratory study...
October 28, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27785163/patients-perception-of-pharmaceutical-services-available-in-a-community-pharmacy-among-patients-living-in-a-rural-area-of-the-united-kingdom
#19
Piotr Merks, Damian ŚWieczkowski, Miłosz J Jaguszewski
OBJECTIVE: Patients' opinion about prevalence of pharmaceutical services available in a community pharmacy among patients living in a rural area of the United Kingdom. The secondary objective was to identify appropriate action(s) to enhance patients' awareness of pharmaceutical services in rural areas. METHODS: A self-administered, anonymous questionnaire was distributed to patients visiting a community pharmacy in Eye, Suffolk, United Kingdom between July and August, 2015...
July 2016: Pharmacy Practice
https://www.readbyqxmd.com/read/27778036/-biological-characteristics-of-mesenchymal-stem-cell-and-hematopoietic-stem-cell-in-the-co-culture-system
#20
Wei Wei, Chao Xu, Zhi-Yong Ye, Xiao-Jun Huang, Jia-En Yuan, Tian-Bao Ma, Han-Biao Lin, Xiu-Qiong Chen
The aim of the present study was to obtain the qualified hematopoietic stem/progenitor cells (HSC/HPC) and human umbilical cord-mesenchymal stem cells (MSC) in vitro in the co-culture system. Cord blood mononuclear cells were separated from umbilical cord blood by Ficoll lymphocyte separation medium, and then CD34(+) HSC was collected by MACS immunomagnetic beads. The selected CD34(+) HSC/HPC and MSC were transferred into culture flask. IMDM culture medium with 15% AB-type cord plasma supplemented with interleukin-3 (IL-3), IL-6, thrombopoietin (TPO), stem cell factor (SCF) and FMS-like tyrosine kinase 3 ligand (Flt-3L) factors were used as the co-culture system for the amplification of HSC/HPC and MSC...
October 25, 2016: Sheng Li Xue Bao: [Acta Physiologica Sinica]
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