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Anesthesia research

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https://www.readbyqxmd.com/read/29049297/functional-connectivity-structure-of-cortical-calcium-dynamics-in-anesthetized-and-awake-mice
#1
Patrick W Wright, Lindsey M Brier, Adam Q Bauer, Grant A Baxter, Andrew W Kraft, Matthew D Reisman, Annie R Bice, Abraham Z Snyder, Jin-Moo Lee, Joseph P Culver
The interplay between hemodynamic-based markers of cortical activity (e.g. fMRI and optical intrinsic signal imaging), which are an indirect and relatively slow report of neural activity, and underlying synaptic electrical and metabolic activity through neurovascular coupling is a topic of ongoing research and debate. As application of resting state functional connectivity measures is extended further into topics such as brain development, aging and disease, the importance of understanding the fundamental physiological basis for functional connectivity will grow...
2017: PloS One
https://www.readbyqxmd.com/read/29049075/insight-into-our-technology-anesthesia-information-management-systems
#2
Allan F Simpao, Mohamed A Rehman
Anesthesia information management systems (AIMS) have evolved from simple, automated intraoperative record keepers in a select few institutions to widely adopted, sophisticated hardware and software solutions that are integrated into a hospital's electronic health record system and used to manage and document a patient's entire perioperative experience. AIMS implementations have resulted in numerous billing, research, and clinical benefits, yet there remain challenges and areas of potential improvement to AIMS utilization...
October 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29033046/eschar-removal-by-bromelain-based-enzymatic-debridement-nexobrid-%C3%A2-in-burns-an-european-consensus
#3
Christoph Hirche, Antonella Citterio, Henk Hoeksema, Ján Koller, Martina Lehner, José Ramón Martinez, Stan Monstrey, Alexandra Murray, Jan A Plock, Frank Sander, Alexandra Schulz, Benjamin Ziegler, Ulrich Kneser
Early debridement and/or eschar removal is regarded as a significant step in the treatment of deep partial and full thickness burns. It aims to control wound bioburden and allows early wound closure by conservative treatment or skin grafting. Preservation of viable dermis accompanied by early wound closure, is regarded as a necessary step to reduce scar related complication, e.g. functional limitations and/or unaesthetic scar formation. Aside from the classical techniques of surgical excision as tangential excision for eschar removal, hydro-surgery, maggot therapy, laser, enzymatic debridement have been described as additional techniques in the burn surgeon's armamentarium...
October 12, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29032753/halogenated-agents-and-cardiovascular-surgery-has-mortality-really-decreased
#4
Giovanni Landoni, Juan Carlos Lopez-Delgado, Chiara Sartini, Simona Tamà, Alberto Zangrillo
Halogenated anesthetic agents (desflurane, isoflurane and sevoflurane) may have cardioprotective properties at therapeutic doses against myocardial intraoperative ischemia-reperfusion injury. Cardioprotection mechanisms are related to mitochondrial and anti-apoptotic signaling pathways. Experimental and human studies have proven that their use may reduce morbidity and mortality in the setting of cardiac surgery, including a reduction in myocardial infarct size and mechanical ventilation needs. On the contrary, total intra-venous propofol based anesthesia may be detrimental...
October 10, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29027773/perioperative-pain-management-in-cardiac-surgery-a-systematic-review
#5
Elena Bignami, Alberto Castella, Vincenzo Pota, Francesco Saglietti, Antonio Scognamiglio, Cinzia Trumello, Maria C Pace, Massimo Allegri
BACKGROUND: Every year, more than 1.5 million patients, who undergo cardiac surgery worldwide, are exposed to a series of factors that can trigger acute postoperative pain associated with hemodynamic instability, respiratory complications, and psychological disorders. Through an evaluation of literature data about postoperative pain in cardiac surgery we define unmet needs and potential objectives for future research on this often underestimated problem. METHODS: Following PRISMA Guidelines, a systematic literature search was carried out by two independent researchers on Scopus, CINAHL, the Cochrane Library, and PubMed using the keywords: [(perioperative OR postoperative) analgesia AND "cardiac surgery"]...
October 12, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29019577/influence-of-the-colon-in-liver-regeneration-of-rats-submitted-to-hepatectomy-and-colectomy
#6
Marília Carvalho Moreira, Ítalo Medeiros Azevedo, Cláudia Nunes Oliveira, Aldo da Cunha Medeiros
OBJECTIVE: to evaluate whether colectomy, associated with 70% hepatectomy, influences liver regeneration in rats. METHODS: we distributed 18 Wistar rats in three groups of six animals each. In group I (sham), we performed laparotomy; In group II, colectomy + 70% hepatectomy; In group III, only 70% hepatectomy. On the 6th postoperative day, we collected blood by cardiac puncture under anesthesia, followed by euthanasia. We performed serum dosages of aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin and alkaline phosphatase (AF), hepatocyte growth factor (HGF) and transforming growth factor-α (TGF-α)...
September 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28994752/a-technique-for-subcutaneous-abdominal-adipose-tissue-biopsy-via-a-non-diathermy-method
#7
Vasileios Chachopoulos, Petros C Dinas, Markella Chasioti, Athanasios Ζ Jamurtas, Yiannis Koutedakis, Andreas D Flouris
Adipose tissue biopsies offer tissue samples that, upon analysis, may provide insightful overviews of mechanisms relating to metabolism and disease. To obtain subcutaneous adipose tissue biopsies in the abdominal area, researchers and physicians use either a surgical or a needle-based technique. However, surgical subcutaneous fat biopsies can offer tissue samples that may provide a more comprehensive overview of the complexities of biological indices in white adipose tissue. Usually, a surgical adipose tissue biopsy includes a diathermy treatment for cauterizing blood vessels to prevent excessive bleeding...
September 30, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28991115/preventing-adverse-events-in-cataract-surgery-recommendations-from-a-massachusetts-expert-panel
#8
Karen C Nanji, Sarah A Roberto, Michael G Morley, Joseph Bayes
Massachusetts health care facilities reported a series of cataract surgery-related adverse events (AEs) to the state in recent years, including 5 globe perforations during eye blocks performed by 1 anesthesiologist in a single day. The Betsy Lehman Center for Patient Safety, a nonregulatory Massachusetts state agency, responded by convening an expert panel of frontline providers, patient safety experts, and patients to recommend strategies for mitigating patient harm during cataract surgery. The purpose of this article is to identify contributing factors to the cataract surgery AEs reported in Massachusetts and present the panel's recommended strategies to prevent them...
October 4, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28988856/a-3d-printed-modular-device-for-imaging-the-brain-of-small-birds
#9
Christine R Lattin, Maxwell A Emerson, Jean-Dominique Gallezot, Tim Mulnix, J Elliott Brown, Richard E Carson
BACKGROUND: One potential barrier to using in vivo imaging in any new animal species is solving the basic problem of how to hold animals safely and securely during scans. NEW METHOD: In this paper, we describe the design, fabrication, use, and positional reproducibility of a 3D-printed plastic device (the Avian Imaging Device, or AID) for imaging the brain of 1 or 2 small songbirds. We designed two different types of head cones to use with this device: one that was not contoured and designed for anesthesia induction, and one contoured to the shape of a house sparrow head, designed to be used with a pre-anesthetized animal...
October 6, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28984099/postoperative-delirium-and-postoperative-cognitive-dysfunction-updates-in-pathophysiology-potential-translational-approaches-to-clinical-practice-and-further-research-perspectives
#10
Marco Cascella, Maria R Muzio, Sabrina Bimonte, Arturo Cuomo, Jan G Jakobsson
Postoperative delirium, the onset of confusion/delirium during the early postoperative phase, is the most common post-operative complication in older adults and represents a medical emergency that requires immediate assessment and treatment. On the other hand, the term postoperative cognitive decline or dysfunction refers to a wide spectrum of clinical conditions featuring a decline in a variety of neuropsychological domains including memory, executive functioning, and speed of processing emerging week to months after anesthesia and surgery...
October 4, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28982261/time-to-institutional-review-board-approval-with-local-versus-central-review-in-a-multicenter-pragmatic-trial
#11
Mark D Neuman, Lakisha J Gaskins, Tracy Ziolek
BACKGROUND/AIMS: Central institutional review board (IRB) review will be required for National Institutes of Health-funded multisite human subjects research as of January 2018, with similar requirements extending to most US multisite human research in 2020. Nonetheless, little is known regarding the relative efficiency of central versus local IRB review for multicenter studies. We compared the amount of time required for central versus local IRB review and approval for sites in one ongoing multicenter randomized trial...
October 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28968282/recent-advances-of-simulation-in-obstetric-anesthesia
#12
Leslie A Schornack, Curtis L Baysinger, May C M Pian-Smith
PURPOSE OF REVIEW: Simulation training in obstetric anesthesia has become widespread in recent years. Simulations are used to train staff and trainees, assess and improve team performance, and evaluate the work environment. This review summarizes current research in these categories. RECENT FINDINGS: Simulation to improve individual technical skills has focused on induction of general anesthesia for emergent cesarean delivery, an infrequently encountered scenario by anesthesia trainees...
September 28, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28968279/incidence-of-artifacts-and-deviating-values-in-research-data-obtained-from-an-anesthesia-information-management-system-in-children
#13
Anne-Lee J Hoorweg, Wietze Pasma, Leo van Wolfswinkel, Jurgen C de Graaff
BACKGROUND: Vital parameter data collected in anesthesia information management systems are often used for clinical research. The validity of this type of research is dependent on the number of artifacts. METHODS: In this prospective observational cohort study, the incidence of artifacts in anesthesia information management system data was investigated in children undergoing anesthesia for noncardiac procedures. Secondary outcomes included the incidence of artifacts among deviating and nondeviating values, among the anesthesia phases, and among different anesthetic techniques...
September 29, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28968196/report-of-workshop-on-euthanasia-for-zebrafish-a-matter-of-welfare-and-science
#14
Almut Köhler, Chereen Collymore, Karin Finger-Baier, Robert Geisler, Larissa Kaufmann, Kieran C Pounder, Stefan Schulte-Merker, Ana Valentim, Zoltan M Varga, Jürgen Weiss, Uwe Strähle
The increasing importance of zebrafish as a biomedical model organism is reflected by the steadily growing number of publications and laboratories working with this species. Regulatory recommendations for euthanasia as issued in Directive 2010/63/EU are, however, based on experience with fish species used for food production and do not take the small size and specific physiology of zebrafish into account. Consequently, the currently recommended methods of euthanasia in the Directive 2010/63/EU are either not applicable or may interfere with research goals...
October 2, 2017: Zebrafish
https://www.readbyqxmd.com/read/28967439/new-evidence-in-one-lung-ventilation
#15
H Meleiro, I Correia, P Charco Mora
Mechanical ventilation in thoracic surgery has undergone significant changes in recent years due to the implementation of the protective ventilation. This review will analyze recent ventilatory strategies in one-lung ventilation. A MEDLINE research was performed using Mesh term "One-Lung Ventilation" including randomized clinical trials, metanalysis, reviews and systematic reviews published in the last 6 years. Search was performed on 21st March 2017. A total of 75 articles were initially found. After title and abstract review 14 articles were included...
September 26, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28965442/the-impact-of-curve-severity-on-obstetric-complications-and-regional-anesthesia-utilization-in-pregnant-patients-with-adolescent-idiopathic-scoliosis-a-preliminary-analysis
#16
Emily W Chan, Stephen R Gannon, Chevis N Shannon, Jeffrey E Martus, Gregory A Mencio, Christopher M Bonfield
OBJECTIVE Adolescent idiopathic scoliosis (AIS), the most common type of scoliosis, often presents immediately prior to a woman's childbearing years; however, research investigating the impact of AIS on women's health, particularly pregnancy delivery outcomes, is sparse, with existing literature reporting mixed findings. Similarly limited are studies examining the change in scoliotic curve during or after pregnancy. Therefore, this study aims to determine 1) the impact of scoliotic curvature on obstetric complications (preterm births, induction of labor, and urgent/emergency caesarean section delivery), 2) regional anesthetic decision making and success during delivery for these patients, and 3) the effect of pregnancy on curve progression...
October 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28965158/influence-of-non-invasive-blood-pressure-measurement-intervals-on-the-occurrence-of-intra-operative-hypotension
#17
Grant H Kruger, Amy Shanks, Sachin Kheterpal, Tyler Tremper, Chi-Jung Chiang, Robert E Freundlich, James M Blum, Albert J Shih, Kevin K Tremper
The American Society of Anesthesiologists Standards for Basic Monitoring recommends blood pressure (BP) measurement every 5 min. Research has shown distractions or technical factors can cause prolonged measurement intervals exceeding 5 min. We investigated the relationship between prolonged non-invasive BP (NIBP) measurement interval and the incidence of hypotension, detected post-interval. Our secondary outcome was to determine independent predictors of these prolonged NIBP measurement intervals. Retrospective data were analyzed from 139,509 general anesthesia cases from our institution's Anesthesia Information Management System (AIMS)...
September 30, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28961558/research-productivity-and-rankings-of-anesthesiology-departments-in-canada-and-the-united-states-the-relationship-between-the-h-index-and-other-common-metrics
#18
Alexandra C Bunting, Sepand Alavifard, Benjamin Walker, Donald R Miller, Tim Ramsay, Sylvain Boet
BACKGROUND: To evaluate the relative research productivity and ranking of anesthesiology departments in Canada and the United States, using the Hirsch index (h-index) and 4 other previously validated metrics. METHODS: We identified 150 anesthesiology departments in Canada and the United States with an accredited residency program. Publications for each of the 150 departments were identified using Thomson's Institute for Scientific Information Web of Science, and the citation report for each department was exported...
September 28, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28953509/procaine-and-local-anesthetic-toxicity-a-collaboration-between-the-clinical-and-basic-sciences
#19
James Seth Jacob, Anthony L Kovac
In 1924, the Therapeutic Research Committee of the American Medical Association appointed a special committee to investigate deaths following the administration of local anesthetics. The Committee for the Study of Toxic Effects of Local Anesthetics found procaine, although a safer clinical alternative to cocaine, was capable of causing death when large doses were injected into tissues and advised that it should be used with caution. This article describes a collaboration beginning in 1928 between Dr John Lundy of the Mayo Clinic and Dr Robert Isenberger of the University of Kansas, which arose from a controversy surrounding systemic adverse reactions to procaine...
November 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28938302/anesthesia-information-management-clinical-decision-support
#20
Robert E Freundlich, Jesse M Ehrenfeld
PURPOSE OF REVIEW: Perioperative informatics tools continue to be developed at a rapid pace and offer clinicians the potential to greatly enhance clinical decision making. The goal of this review is to bring the reader updates on perioperative information management and discuss future research directions in the field. RECENT FINDINGS: Clinical decision support tools become more timely, accurate, and, in some instances, have been shown to improve patient outcomes...
September 21, 2017: Current Opinion in Anaesthesiology
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