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J Vega

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https://www.readbyqxmd.com/read/28099917/cleavage-of-fibulin-2-by-the-aggrecanases-adamts-4-and-adamts-5-contributes-to-the-tumorigenic-potential-of-breast-cancer-cells
#1
Tania Fontanil, Saúl Álvarez-Teijeiro, M Ángeles Villaronga, Yamina Mohamedi, Laura Solares, Angela Moncada-Pazos, José A Vega, Olivia García-Suárez, Marcos Pérez-Basterrechea, Juana M García-Pedrero, Alvaro J Obaya, Santiago Cal
Fibulin-2 participates in the assembly of extracellular matrix components through interactions with multiple ligands and promotes contacts between cells and their surrounding environment. Consequently, identification of processes that could lead to an altered Fibulin-2 could have a major impact not only in the maintenance of tissue architecture and morphogenesis but also in pathological situations including cancer. Herein, we have investigated the ability of the secreted metalloproteases ADAMTS-4 and ADAMTS-5 to digest Fibulin-2...
January 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28076856/mri-differences-associated-with-intrauterine-growth-restriction-in-preterm-infants
#2
Christie J Bruno, Shreyans Bengani, William A Gomes, Mariana Brewer, Melissa Vega, Xianhong Xie, Mimi Kim, Mamta Fuloria
BACKGROUND: Preterm infants are at risk for neurodevelopmental impairment. Intrauterine growth restriction (IUGR) further increases this risk. Brain imaging studies are often utilized at or near term-equivalent age to determine later prognosis. OBJECTIVE: To evaluate the association between intrauterine growth and regional brain volume on MRI scans performed in preterm infants at or near term-equivalent age. METHODS: This is a retrospective case-control study of 24 infants born at gestational age ≤30 weeks and cared for in a large, inner-city, academic neonatal intensive-care unit from 2012 to 2013...
January 11, 2017: Neonatology
https://www.readbyqxmd.com/read/28060326/network-analysis-of-foramen-ovale-electrode-recordings-in-drug-resistant-temporal-lobe-epilepsy-patients
#3
Ancor Sanz-García, Lorena Vega-Zelaya, Jesús Pastor, Cristina V Torres, Rafael G Sola, Guillermo J Ortega
Approximately 30% of epilepsy patients are refractory to antiepileptic drugs. In these cases, surgery is the only alternative to eliminate/control seizures. However, a significant minority of patients continues to exhibit post-operative seizures, even in those cases in which the suspected source of seizures has been correctly localized and resected. The protocol presented here combines a clinical procedure routinely employed during the pre-operative evaluation of temporal lobe epilepsy (TLE) patients with a novel technique for network analysis...
December 18, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28059788/silicic-acid-and-beer-consumption-reverses-the-metal-imbalance-and%C3%A2-the%C3%A2-prooxidant-status-induced-by%C3%A2-aluminum-nitrate-in-mouse-brain
#4
María José González-Muñoz, Alba Garcimartán, Isabel Meseguer, Carmen José Mateos-Vega, José María Orellana, Antonio Peña-Fernández, Juana Benedí, Francisco J Sánchez-Muniz
BACKGROUND: Emerging evidence suggests that by affecting mineral balance, aluminum (Al) may enhance some events associated with neurodegenerative diseases. AIM: To examine the effect of Al(NO3)3 exposure on brain Al, cooper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), silicon (Si), and zinc (Zn) levels, and the metal-change implication in brain oxidant and inflammatory status. METHODS: Four groups of six-week-old male NMRI mice were treated for three months: i) controls, administrated with deionized water; ii) Al, which received Al(NO3)3; iii) Al+silicic acid, which were given Al(NO3)3 plus silicic acid; and iv) Al+beer, which received Al(NO3)3 plus beer...
December 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28059068/cdk4-6-or-mapk-blockade-enhances-efficacy-of-egfr-inhibition-in-oesophageal-squamous-cell-carcinoma
#5
Jin Zhou, Zhong Wu, Gabrielle Wong, Eirini Pectasides, Ankur Nagaraja, Matthew Stachler, Haikuo Zhang, Ting Chen, Haisheng Zhang, Jie Bin Liu, Xinsen Xu, Ewa Sicinska, Francisco Sanchez-Vega, Anil K Rustgi, J Alan Diehl, Kwok-Kin Wong, Adam J Bass
Oesophageal squamous cell carcinoma is a deadly disease where systemic therapy has relied upon empiric chemotherapy despite the presence of genomic alterations pointing to candidate therapeutic targets, including recurrent amplification of the gene encoding receptor tyrosine kinase epidermal growth factor receptor (EGFR). Here, we demonstrate that EGFR-targeting small-molecule inhibitors have efficacy in EGFR-amplified oesophageal squamous cell carcinoma (ESCC), but may become quickly ineffective. Resistance can occur following the emergence of epithelial-mesenchymal transition and by reactivation of the mitogen-activated protein kinase (MAPK) pathway following EGFR blockade...
January 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28057375/description-of-a-new-anaerobic-thermophilic-bacterium-thermoanaerobacterium-butyriciformans-sp-nov
#6
G López, S J Cañas-Duarte, A M Pinzón-Velasco, N E Vega-Vela, M Rodríguez, S Restrepo, S Baena
Strain USBA-019(T), an anaerobic and thermophilic strain, was identified as a new member of the genus Thermoanaerobacterium. USBA-019(T) cells are gram-positive, strictly anaerobic, thermophilic, chemoorganotrophic, moderately acidophilic, non-motile, endospore-forming, slightly curved, and rod-shaped. Cells measure 0.4×3.0-7.0μm. Optimal growth occurs at 50-55°C (35-65°C). Optimum pH is 5.0-5.5 (4.0-8.5). Thiosulfate, elemental sulfur and nitrate were utilized as electron acceptors. Fermentation of glucose, lactose, cellobiose, galactose, arabinose, xylose, starch and xylan primarily produced acetate and butyrate...
December 16, 2016: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/28048750/su-f-j-26-performance-of-2-5mv-portal-imaging-in-comparison-with-kv-x-ray-and-6mv-and-flattening-filter-free-6mv-portal-imaging
#7
J Duan, Y Yang, A Faught, E Subashi, Q Wu, F Yin
PURPOSE: To assess image quality and imaging dose of 2.5MV electronic portal imaging in comparison to kV imaging and 6MV and Flattening-Filter-Free 6MV (6MVFFF) portal imaging using a DMI imager. METHODS: Quantitative assessment of image quality was performed with Leeds and Las Vegas test phantoms in conjunction with qualitative evaluation of clinical patient images for kV imaging and 2.5MV, 6MV and 6MVFFF portal imaging. High and low contrast resolutions were evaluated and imaging doses were measured using these x-rays...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046350/we-de-bra-04-a-cost-effective-pixelated-epid-scintillator-for-enhanced-contrast-and-dqe
#8
J Rottmann, M Myronakis, Y Hu, D Shedlock, A Wang, D Humber, D Morf, R Fueglistaller, J Star-Lack, R Berbeco
PURPOSE: Beams-eye-view imaging applications such as real-time soft-tissue motion estimation and MV-CBCT are hindered by the inherently low image contrast of electronic portal imaging devices (EPID) currently in clinical use. We investigate a cost effective scintillating glass that provides substantially increased detective quantum efficiency (DQE) and contrast to noise ratio (CNR). METHODS: A pixelated scintillator prototype was built from LKH-5 glass. The array is 12mm thick; 42...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046160/requirement-for-digestible-calcium-by-25-to-50-kg-pigs-at-different-dietary-concentrations-of-phosphorus-as-indicated-by-growth-performance-bone-ash-concentration-and-calcium-and-phosphorus-balances
#9
J C González-Vega, C L Walk, M R Murphy, H H Stein
Two experiments were conducted to determine the requirement for standardized total tract digestible (STTD) Ca by 25 to 50 kg pigs at different concentrations of STTD P. Twenty corn-soybean meal based diets were formulated with diets containing 4 concentrations of STTD P (0.15, 0.31, 0.39, or 0.47%) and 5 concentrations of STTD Ca (0.13, 0.27, 0.42, 0.57, or 0.72%). Diets were mixed in 1 batch and were used in both experiments. In Exp. 1, 240 pigs (initial average BW: 24.70 ± 1.27 kg) were randomly allotted to the 20 diets in 6 blocks with 1 pen per diet in each block using a 4 × 5 factorial design...
December 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/28045901/zika-virus-infection-as-a-cause-of-congenital-brain-abnormalities-and-guillain-barr%C3%A3-syndrome-systematic-review
#10
Fabienne Krauer, Maurane Riesen, Ludovic Reveiz, Olufemi T Oladapo, Ruth Martínez-Vega, Teegwendé V Porgo, Anina Haefliger, Nathalie J Broutet, Nicola Low
BACKGROUND: The World Health Organization (WHO) stated in March 2016 that there was scientific consensus that the mosquito-borne Zika virus was a cause of the neurological disorder Guillain-Barré syndrome (GBS) and of microcephaly and other congenital brain abnormalities based on rapid evidence assessments. Decisions about causality require systematic assessment to guide public health actions. The objectives of this study were to update and reassess the evidence for causality through a rapid and systematic review about links between Zika virus infection and (a) congenital brain abnormalities, including microcephaly, in the foetuses and offspring of pregnant women and (b) GBS in any population, and to describe the process and outcomes of an expert assessment of the evidence about causality...
January 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28024184/serpinb9-is-a-marker-of-antigen-cross-presenting-dendritic-cells
#11
M S Mangan, J Vega-Ramos, L T Joeckel, A J Mitchell, A Rizzitelli, B Roediger, D Kaiserman, W W Weninger, J A Villadangos, P I Bird
Serpinb9 (Sb9, also called Spi6) is an intracellular inhibitor of granzyme B (grB) that protects cytotoxic lymphocytes from grB-mediated death. In addition, Sb9 is also expressed in accessory immune cells, including dendritic cells (DCs), although its role is debated. Recently, we have demonstrated that Sb9 plays a grB-independent role in cross-presentation of antigens by CD8(+) DCs. Here, using a mouse line expressing green fluorescent protein knocked in under the control of the Sb9 promoter, we demonstrate that Sb9 expression is highest in those tissue-resident and migratory DC subsets capable of cross-presentation...
December 23, 2016: Molecular Immunology
https://www.readbyqxmd.com/read/28018661/shaping-communicative-colour-signals-over-evolutionary-time
#12
Alison G Ossip-Drahos, José R Oyola Morales, Cuauhcihuatl Vital-García, J Jaime Zúñiga-Vega, Diana K Hews, Emília P Martins
Many evolutionary forces can shape the evolution of communicative signals, and the long-term impact of each force may depend on relative timing and magnitude. We use a phylogenetic analysis to infer the history of blue belly patches of Sceloporus lizards, and a detailed spectrophotometric analysis of four species to explore the specific forces shaping evolutionary change. We find that the ancestor of Sceloporus had blue patches. We then focus on four species; the first evolutionary shift (captured by comparison of S...
November 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27994592/kir-genes-and-their-ligands-predict-the-response-to-anti-egfr-monoclonal-antibodies-in-solid-tumors
#13
Cristina Morales-Estevez, Juan De la Haba-Rodriguez, Barbara Manzanares-Martin, Ignacio Porras-Quintela, Antonio Rodriguez-Ariza, Alberto Moreno-Vega, Maria J Ortiz-Morales, Maria A Gomez-España, Maria T Cano-Osuna, Javier Lopez-Gonzalez, Beatriz Chia-Delgado, Rafael Gonzalez-Fernandez, Enrique Aranda-Aguilar
Killer-cell immunoglobulin-like receptors (KIRs) regulate the killing function of natural killer cells, which play an important role in the antibody-dependent cell-mediated cytotoxicity response exerted by therapeutic monoclonal antibodies (mAbs). However, it is unknown whether the extensive genetic variability of KIR genes and/or their human leukocyte antigen (HLA) ligands might influence the response to these treatments. This study aimed to explore whether the variability in KIR/HLA genes may be associated with the variable response observed to mAbs based anti-epidermal growth factor receptor (EGFR) therapies...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27983809/a-collaborative-study-determination-of-mycotoxins-in-corn-peanut-butter-and-wheat-flour-using-stable-isotope-dilution-assay-sida-and-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms
#14
Kai Zhang, Matthew R Schaab, Gavin Southwood, Elizabeth R Tor, Linda S Aston, Wenlu Song, Brian Eitzer, Sanghamitra Majumdar, Theodore Lapainis, Huy Mai, Kevin Tran, Aref El-Demerdash, Victor Vega, Yanxuan Cai, Jon W Wong, Alexandra J Krynitsky, Timothy H Begley
A collaborative study was conducted to evaluate stable isotope dilution assay (SIDA) and LC-MS/MS for the simultaneous determination of aflatoxins B1, B2, G1, and G2; deoxynivalenol; fumonisins B1, B2, and B3; ochratoxin A; HT-2 toxin; T-2 toxin; and zearalenone in foods. Samples were fortified with 12 (13)C uniformly labeled mycotoxins ((13)C-IS) corresponding to the native mycotoxins and extracted with acetonitrile/water (50:50 v/v), followed by centrifugation, filtration, and LC-MS/MS analysis. In addition to certified reference materials, the six participating laboratories analyzed corn, peanut butter, and wheat flour fortified with the 12 mycotoxins at concentrations ranging from 1...
January 3, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27976763/what-will-freestanding-borophene-nanoribbons-look-like-an-analysis-of-their-possible-structures-magnetism-and-transport-properties
#15
A García-Fuente, J Carrete, A Vega, L J Gallego
We report a density-functional theory study of the stability and electronic structure of two recently proposed borophene sheets with Pmmn symmetry and nonzero thickness. We then investigate nanoribbons (BNRs) derived from these nanostructures, with particular attention to technologically relevant properties like magnetism and electronic transport. We consider two perpendicular directions for the edges of the stripes as well as different lateral widths. We show that the Pmmn8 sheet, with 8 atoms in its unit cell and generated by two interpenetrating lattices, has a larger binding energy than the Pmmn2 sheet, with only 2 atoms per unit cell...
January 4, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27976536/a-facile-and-versatile-method-to-endow-biomaterial-devices-with-zwitterionic-surface-coatings
#16
Volkan Yesilyurt, Omid Veiseh, Joshua C Doloff, Jie Li, Suman Bose, Xi Xie, Andrew R Bader, Michael Chen, Matthew J Webber, Arturo J Vegas, Robert Langer, Daniel G Anderson
The surface modification of implantable biomaterials with zwitterionic phosphorylcholine polymer is demonstrated through mussel-mimetic catecholamine polymer thin films. Using this method, the surfaces of alginate hydrogel microspheres and polystyrene microbeads, a model material known to produce robust foreign body responses and fibrosis, are successfully modified to reduce the tissue reaction by reducing the fibrosis in immunocompetent C57BL/6J mice.
December 15, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27974952/derivation-of-a-test-statistic-for-emphysema-quantification
#17
Gonzalo Vegas-Sanchez-Ferrero, George Washko, Farbod N Rahaghi, Maria J Ledesma-Carbayo, R San José Estépar
Density masking is the de-facto quantitative imaging phenotype for emphysema that is widely used by the clinical community. Density masking defines the burden of emphysema by a fixed threshold, usually between -910 HU and -950 HU, that has been experimentally validated with histology. In this work, we formalized emphysema quantification by means of statistical inference. We show that a non-central Gamma is a good approximation for the local distribution of image intensities for normal and emphysema tissue. We then propose a test statistic in terms of the sample mean of a truncated non-central Gamma random variable...
April 2016: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
https://www.readbyqxmd.com/read/27973712/experimental-evidence-for-sexual-selection-against-inbred-males
#18
Regina Vega-Trejo, Megan L Head, J Scott Keogh, Michael D Jennions
(1)The detrimental effects of matings between relatives are well known. However, few studies determine the extent to which inbreeding depression in males is due to natural or sexual selection. Importantly, measuring fitness or key fitness components, rather than phenotypic traits allows more accurate estimation of inbreeding depression. (2)We investigate how differences in inbreeding and juvenile diet (i.e. early stressful environment) influence a key component of male fitness, namely their reproductive success...
December 14, 2016: Journal of Animal Ecology
https://www.readbyqxmd.com/read/27970304/tct-137-influence-of-non-culprit-lesions-management-on-outcomes-in-patients-over-75-years-old-with-st-elevated-myocardial-infarction-results-from-the-estrofa-mi-75-nation-wide-registry
#19
Jose M de la Torre Hernandez, Joan Antoni Gomez Hospital, Salvatore Brugaletta, Jose Antonio Baz, Armando Perez de Prado, Ramon Lopez Palop, Ana Belen Cid Alvarez, Tamara Garcia Camarero, Alejandro Diego Nieto, Federico Gimeno, Jose Antonio Fernandez Diaz, Juan Sanchis Fores, Fernando Alfonso, Roberto Blanco, Javier Botas, Javier Navarro Cuartero, Jose Moreu Burgos, Francisco Bosa, Jose Miguel Vegas, Jaime Elizaga, Antonio Luis Arrebola Moreno, Joseantonio Linares Vicente, Felipe Hernandez, Neus Salvatella Giralt, Marta Monteagudo, Alfredo Gomez Jaume, Xavier Carrillo, Roberto Martin-Reyes, Fernando Lozano, Jose Rumoroso, Leire Andraka, Antonio J Dominguez
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970282/tct-120-primary-angioplasty-for-patients-over-75-years-old-in-cardiogenic-shock-contemporary-results-and-prognostic-predictors-from-the-estrofa-mi-75-nationwide-registry
#20
Jose M de la Torre Hernandez, Salvatore Brugaletta, Joan Antoni Gomez Hospital, Jose Antonio Baz, Armando Perez de Prado, Ramon Lopez Palop, Ana Belen Cid Alvarez, Tamara Garcia Camarero, Alejandro Diego Nieto, Federico Gimeno, Jose Antonio Fernandez Diaz, Juan Sanchis Fores, Fernando Alfonso, Roberto Blanco, Javier Botas, Javier Navarro Cuartero, Jose Moreu Burgos, Francisco Bosa, Jose Miguel Vegas, Jaime Elizaga, Antonio Luis Arrebola Moreno, Jose R Ruiz Arroyo, Felipe Hernandez, Neus Salvatella Giralt, Marta Monteagudo, Alfredo Gomez Jaume, Xavier Carrillo, Roberto Martin-Reyes, Fernando Lozano, Jose Rumoroso, Leire Andraka, Antonio J Dominguez
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
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