keyword
MENU ▼
Read by QxMD icon Read
search

J Vega

keyword
https://www.readbyqxmd.com/read/29221973/pathogens-toolbox-to-manipulate-human-complement
#1
REVIEW
Francisco J Fernández, Sara Gómez, M Cristina Vega
The surveillance and pathogen fighting functions of the complement system have evolved to protect mammals from life-threatening infections. In turn, pathogens have developed complex molecular mechanisms to subvert, divert and evade the effector functions of the complement. The study of complement immunoevasion by pathogens sheds light on their infection drivers, knowledge that is essential to implement therapies. At the same time, complement evasion also acts as a discovery ground that reveals important aspects of how complement works under physiological conditions...
December 5, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29220425/a-leaflet-plication-clip-is-an-effective-surgical-template-for-mitral-valve-foldoplasty
#2
Isaac Wamala, Mossab Saeed, Sunil J Ghelani, Kimberlee Gauvreau, Peter E Hammer, Nikolay V Vasilyev, Pedro J Del Nido
OBJECTIVES: During mitral valve repair using the foldoplasty technique, correct judgement of the necessary dimensions and orientation of the leaflet fold is a critical but challenging step that can affect the chances of successful repair. In this study, we investigated whether a leaflet plication clip can be used to guide suture foldoplasty for posterior leaflet prolapse of the mitral valve. METHODS: Complete posterior leaflet prolapse was created in both in vivo and ex vivo pig hearts by severing the chordae supporting the middle scallop...
December 6, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29217570/a-precise-measurement-of-the-magnetic-field-in-the-corona-of-the-black-hole-binary-v404-cygni
#3
Yigit Dallilar, Stephen S Eikenberry, Alan Garner, Richard D Stelter, Amy Gottlieb, Poshak Gandhi, Piergiorgio Casella, Vik S Dhillon, Tom R Marsh, Stuart P Littlefair, Liam Hardy, Rob Fender, Kunal Mooley, Dominic J Walton, Felix Fuerst, Matteo Bachetti, A J Castro-Tirado, Miguel Charcos, Michelle L Edwards, Nestor M Lasso-Cabrera, Antonio Marin-Franch, S Nicholas Raines, Kendall Ackley, John G Bennett, A Javier Cenarro, Brian Chinn, H Veronica Donoso, Raymond Frommeyer, Kevin Hanna, Michael D Herlevich, Jeff Julian, Paola Miller, Scott Mullin, Charles H Murphey, Chris Packham, Frank Varosi, Claudia Vega, Craig Warner, A N Ramaprakash, Mahesh Burse, Sujit Punnadi, Pravin Chordia, Andreas Gerarts, Héctor de Paz Martín, María Martín Calero, Riccardo Scarpa, Sergio Fernandez Acosta, William Miguel Hernández Sánchez, Benjamin Siegel, Francisco Francisco Pérez, Himar D Viera Martín, José A Rodríguez Losada, Agustín Nuñez, Álvaro Tejero, Carlos E Martín González, César Cabrera Rodríguez, Jordi Molgó, J Esteban Rodriguez, J Israel Fernández Cáceres, Luis A Rodríguez García, Manuel Huertas Lopez, Raul Dominguez, Tim Gaggstatter, Antonio Cabrera Lavers, Stefan Geier, Peter Pessev, Ata Sarajedini
Observations of binary stars containing an accreting black hole or neutron star often show x-ray emission extending to high energies (>10 kilo--electron volts), which is ascribed to an accretion disk corona of energetic particles akin to those seen in the solar corona. Despite their ubiquity, the physical conditions in accretion disk coronae remain poorly constrained. Using simultaneous infrared, optical, x-ray, and radio observations of the Galactic black hole system V404 Cygni, showing a rapid synchrotron cooling event in its 2015 outburst, we present a precise 461 ± 12 gauss magnetic field measurement in the corona...
December 8, 2017: Science
https://www.readbyqxmd.com/read/29216595/optimizing-prescribed-fire-allocation-for-managing-fire-risk-in-central-catalonia
#4
Fermín J Alcasena, Alan A Ager, Michele Salis, Michelle A Day, Cristina Vega-Garcia
We used spatial optimization to allocate and prioritize prescribed fire treatments in the fire-prone Bages County, central Catalonia (northeastern Spain). The goal of this study was to identify suitable strategic locations on forest lands for fuel treatments in order to: 1) disrupt major fire movements, 2) reduce ember emissions, and 3) reduce the likelihood of large fires burning into residential communities. We first modeled fire spread, hazard and exposure metrics under historical extreme fire weather conditions, including node influence grid for surface fire pathways, crown fraction burned and fire transmission to residential structures...
December 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29205258/sustained-intra-cartilage-delivery-of-low-dose-dexamethasone-using-a-cationic-carrier-for-treatment-of-post-traumatic-osteoarthritis
#5
A G Bajpayee, R E De la Vega, M Scheu, N H Varady, I A Yannatos, L A Brown, Y Krishnan, T J Fitzsimons, P Bhattacharya, E H Frank, A J Grodzinsky, R M Porter
Disease-modifying osteoarthritis drugs (DMOADs) should reach their intra-tissue target sites at optimal doses for clinical efficacy. The dense, negatively charged matrix of cartilage poses a major hindrance to the transport of potential therapeutics. In this work, electrostatic interactions were utilised to overcome this challenge and enable higher uptake, full-thickness penetration and enhanced retention of dexamethasone (Dex) inside rabbit cartilage. This was accomplished by using the positively charged glycoprotein avidin as nanocarrier, conjugated to Dex by releasable linkers...
December 5, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/29198929/racial-differences-in-the-development-of-de-novo-donor-specific-antibodies-and-treated-antibody-mediated-rejection-after-heart-transplantation
#6
Robert Townsend Cole, Jonathan Gandhi, Robert A Bray, Howard M Gebel, Michael Yin, Nikolaz Shekiladze, An Young, Aubrey Grant, Ian Mahoney, S Raja Laskar, Divya Gupta, Kunal Bhatt, Wendy Book, Andrew Smith, Duc Nguyen, J David Vega, Alanna A Morris
BACKGROUND: Despite improvements in outcomes after heart transplantation, black recipients have worse survival compared with non-black recipients. The source of such disparate outcomes remains largely unknown. We hypothesize that a propensity to generate de-novo donor-specific antibodies (dnDSA) and subsequent antibody-mediated rejection (AMR) may account for racial differences in sub-optimal outcomes after heart transplant. In this study we aimed to determine the role of dnDSA and AMR in racial disparities in post-transplant outcomes...
November 4, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29196142/new-transgenic-models-of-parkinson-s-disease-using-genome-editing-technology
#7
J A Cota-Coronado, S Sandoval-Ávila, Y P Gaytan-Dávila, N F Diaz, B Vega-Ruiz, E Padilla-Camberos, N E Díaz-Martínez
INTRODUCTION: Parkinson's disease (PD) is the second most common neurodegenerative disorder. It is characterised by selective loss of dopaminergic neurons in the substantia nigra pars compacta, which results in dopamine depletion, leading to a number of motor and non-motor symptoms. DEVELOPMENT: In recent years, the development of new animal models using nuclease-based genome-editing technology (ZFN, TALEN, and CRISPR/Cas9 nucleases) has enabled the introduction of custom-made modifications into the genome to replicate key features of PD, leading to significant advances in our understanding of the pathophysiology of the disease...
November 28, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29178321/glial-hypothalamic-inhibition-of-glut2-expression-alters-satiety-impacting-eating-behavior
#8
María J Barahona, Paula Llanos, Antonia Recabal, Kathleen Escobar-Acuña, Roberto Elizondo-Vega, Magdiel Salgado, Patricio Ordenes, Elena Uribe, Fernando J Sepúlveda, Ricardo C Araneda, María A García-Robles
Glucose is a key modulator of feeding behavior. By acting in peripheral tissues and in the central nervous system, it directly controls the secretion of hormones and neuropeptides and modulates the activity of the autonomic nervous system. GLUT2 is required for several glucoregulatory responses in the brain, including feeding behavior, and is localized in the hypothalamus and brainstem, which are the main centers that control this behavior. In the hypothalamus, GLUT2 has been detected in glial cells, known as tanycytes, which line the basal walls of the third ventricle (3V)...
November 27, 2017: Glia
https://www.readbyqxmd.com/read/29175366/lack-of-the-nad-dependent-glycerol-3-phosphate-dehydrogenase-impairs-the-function-of-transcription-factors-sip4-and-cat8-required-for-ethanol-utilization-in-kluyveromyces-lactis
#9
Lucía Mojardín, Montserrat Vega, Fernando Moreno, Hans-Peter Schmitz, Jürgen J Heinisch, Rosaura Rodicio
The NAD+-dependent glycerol 3-phosphate dehydrogenase (KlGpd1) is an important enzyme for maintenance of the cytosolic redox balance. In the milk yeast Kluyveromyces lactis The enzyme is localized in peroxisomes and in the cytosol, indicating its requirement for the oxidation of NADH in both compartments. Klgpd1 mutants grow more slowly on glucose than wild-type cells and do not grow on ethanol as a sole carbon source. We studied the molecular basis of the latter phenotype and found that Gpd1 is required for high expression of KlICL1 and KlMLS1 which encode the key enzymes of the glyoxylate pathway isocitrate lyase and malate synthase, respectively...
November 22, 2017: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/29174867/the-synthesis-of-steroids-by-taenia-crassiceps-wfu-cysticerci-and-tapeworms-is-related-to-the-developmental-stages-of-the-parasites
#10
J M Patricio-Gómez, R A Valdez, A Veloz, L Aguilar-Vega, R Zurabian, M C Romano
Taeniids tapeworms are hermaphroditic helminths that gradually develop testis and ovaries in their reproductive units. The larval stage of the tapeworms named cysticercus is a vesicle that contains the scolex and proliferates asexually in the abdominal cavity of mice. Once in the host, they evaginate, attach to the gut and develop into an adult organism, the tapeworm. We have previously reported reported that T. crassiceps ORF and solium cysticerci transform steroid precursors to androgens and estrogens. Taenia crassiceps WFU cysticerci can also synthesize corticosteroids...
November 22, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29174647/stabilization-of-axisymmetric-liquid-bridges-through-vibration-induced-pressure-fields
#11
M Haynes, E J Vega, M A Herrada, E S Benilov, J M Montanero
Previous theoretical studies have indicated that liquid bridges close to the Plateau-Rayleigh instability limit can be stabilized when the upper supporting disk vibrates at a very high frequency and with a very small amplitude. The major effect of the vibration-induced pressure field is to straighten the liquid bridge free surface to compensate for the deformation caused by gravity. As a consequence, the apparent Bond number decreases and the maximum liquid bridge length increases. In this paper, we show experimentally that this procedure can be used to stabilize millimeter liquid bridges in air under normal gravity conditions...
November 21, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29174582/macitentan-in-daily-clinical-practice-a-single-centre-1-year-experience
#12
S Cadenas-Menéndez, P Álvarez-Vega, J Martín-Moreiras, M Barreiro-Pérez, M Á Gómez-Sánchez, P L Sánchez-Fernández
The effectiveness and safety of macitentan, a dual endothelin-receptor antagonist (ERA) approved for the treatment of pulmonary arterial hypertension (PAH), were shown in an extensive clinical trial oriented towards morbidity and mortality events. Our aim was to describe a single centre's experience of the utilization of macitentan in patients with PAH in clinical practice settings. Thirteen patients with different aetiologies and previous PAH treatments were studied. After 12 months of macitentan treatment, 11 patients improved their functional class (FC), all patients improved their 6-minute walk distance (6MWD) test, and 10 patients lowered their NT-proBNP plasma levels...
November 21, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/29169788/stellate-ganglion-block-as-rescue-therapy-in-refractory-vasospasm-after-subarachnoid-hemorrhage
#13
J Sánchez Arguiano, M A Hernández-Hernández, R A Jáuregui Solórzano, S Maldonado-Vega, A González Mandly, J Burón Mediavilla
No abstract text is available yet for this article.
November 20, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/29162227/anti-mda5-positive-dermatomyositis-a-description-of-the-cutaneous-and-systemic-manifestations-in-2-cases
#14
N Barrientos, J J Sicilia, M J Moreno de Vega, J D Dominguez
No abstract text is available yet for this article.
November 18, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29159658/lung-necrosectomy-in-pediatric-patients-with-necrotizing-pneumonia
#15
Francina V Bolaños-Morales, Emmanuel Peña Gómez-Portugal, María E Aguilar-Mena, Patricio J Santillán-Doherty, Avelina Sotres-Vega, J Alfredo Santibáñez-Salgado
INTRODUCTION: Necrotizing pneumonia is the consolidation of lung parenchyma with destruction and necrosis, forming solitary or multiloculated radiolucent foci. When antibiotic treatment fails and clinical course does not improve, patients might need lung tissue resection: segmentectomy, lobectomy or bilobectomy. We have performed a more conservative surgical approach in pediatric patients with necrotizing pneumonia, lung necrosectomy: resection of unviable necrotic tissue, to preserve more healthy and potentially recoverable lung parenchyma...
November 20, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29142317/the-maternal-genetic-make-up-of-the-iberian-peninsula-between-the-neolithic-and-the-early-bronze-age
#16
Anna Szécsényi-Nagy, Christina Roth, Guido Brandt, Cristina Rihuete-Herrada, Cristina Tejedor-Rodríguez, Petra Held, Íñigo García-Martínez-de-Lagrán, Héctor Arcusa Magallón, Stephanie Zesch, Corina Knipper, Eszter Bánffy, Susanne Friederich, Harald Meller, Primitiva Bueno Ramírez, Rosa Barroso Bermejo, Rodrigo de Balbín Behrmann, Ana M Herrero-Corral, Raúl Flores Fernández, Carmen Alonso Fernández, Javier Jiménez Echevarria, Laura Rindlisbacher, Camila Oliart, María-Inés Fregeiro, Ignacio Soriano, Oriol Vicente, Rafael Micó, Vicente Lull, Jorge Soler Díaz, Juan Antonio López Padilla, Consuelo Roca de Togores Muñoz, Mauro S Hernández Pérez, Francisco Javier Jover Maestre, Joaquín Lomba Maurandi, Azucena Avilés Fernández, Katina T Lillios, Ana Maria Silva, Miguel Magalhães Ramalho, Luiz Miguel Oosterbeek, Claudia Cunha, Anna J Waterman, Jordi Roig Buxó, Andrés Martínez, Juana Ponce Martínez, Mark Hunt Ortiz, Juan Carlos Mejías-García, Juan Carlos Pecero Espín, Rosario Cruz-Auñón Briones, Tiago Tomé, Eduardo Carmona Ballestero, João Luís Cardoso, Ana Cristina Araújo, Corina Liesau von Lettow-Vorbeck, Concepción Blasco Bosqued, Patricia Ríos Mendoza, Ana Pujante, José I Royo-Guillén, Marco Aurelio Esquembre Beviá, Victor Manuel Dos Santos Goncalves, Rui Parreira, Elena Morán Hernández, Elena Méndez Izquierdo, Jorge Vega Y Miguel, Roberto Menduiña García, Victoria Martínez Calvo, Oscar López Jiménez, Johannes Krause, Sandra L Pichler, Rafael Garrido-Pena, Michael Kunst, Roberto Risch, Manuel A Rojo-Guerra, Wolfgang Haak, Kurt W Alt
Agriculture first reached the Iberian Peninsula around 5700 BCE. However, little is known about the genetic structure and changes of prehistoric populations in different geographic areas of Iberia. In our study, we focus on the maternal genetic makeup of the Neolithic (~ 5500-3000 BCE), Chalcolithic (~ 3000-2200 BCE) and Early Bronze Age (~ 2200-1500 BCE). We report ancient mitochondrial DNA results of 213 individuals (151 HVS-I sequences) from the northeast, central, southeast and southwest regions and thus on the largest archaeogenetic dataset from the Peninsula to date...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29138870/insig2-rs7566605-single-nucleotide-variant-and-global-dna-methylation-index-levels-are-associated-with-weight-loss-in-a-personalized-weight-reduction-program
#17
Francesca Pirini, Sebastian Rodriguez-Torres, Bola Grace Ayandibu, María Orera-Clemente, Alberto Gonzalez-de la Vega, Fahcina Lawson, Roland J Thorpe, David Sidransky, Rafael Guerrero-Preston
Single nucleotide polymorphisms associated with lipid metabolism and energy balance are implicated in the weight loss response caused by nutritional interventions. Diet‑induced weight loss is also associated with differential global DNA methylation. DNA methylation has been proposed as a predictive biomarker for weight loss response. Personalized biomarkers for successful weight loss may inform clinical decisions when deciding between behavioral and surgical weight loss interventions. The aim of the present study was to investigate the association between global DNA methylation, genetic variants associated with energy balance and lipid metabolism, and weight loss following a non‑surgical weight loss regimen...
November 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29137863/results-and-functional-outcomes-of-acute-ischemic-stroke-patients-who-underwent-mechanical-thrombectomy-admitted-to-intensive-care-unit
#18
L Viña Soria, L Martín Iglesias, L López Amor, I Astola Hidalgo, R Rodríguez García, L Forcelledo Espina, J A Gonzalo Guerra, S de Cima Iglesias, E Murias Quintana, P Vega Valdés, S Calleja Puerta, D Escudero Augusto
PURPOSE: To study the results and complications of endovascular treatment (EVT) in acute ischemic stroke patients admitted to Intensive Care Unit (ICU). To analyse the possible factors related to mortality and level of disability at ICU discharge and one year after stroke. DESIGN: Observational prospective study. SETTING: Mixed ICU. Third level hospital. PATIENTS: Sixty adult patients. Consecutive sample. INTERVENTIONS: None...
November 11, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/29135323/impact-assessment-of-the-rational-selection-of-training-and-test-sets-on-the-predictive-ability-of-qsar-models
#19
M F Andrada, E G Vega-Hissi, M R Estrada, J C Garro Martinez
This study performed an analysis of the influence of the training and test set rational selection on the quality and predictively of the quantitative structure-activity relationship (QSAR) model. The study was carried out on three different datasets of Influenza Neuraminidase (H1N1) inhibitors. The three datasets were divided into training and test sets using three rational selection methods: based on k-means, Kennard-Stone algorithm and Activity and the results were compared with Random selection. Then, a total of 31,490 mathematical models were developed and those models that presented a determination coefficient higher than: r(2)train > 0...
November 14, 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/29130816/the-role-of-perceived-family-social-support-and-parental-solicitous-responses-in-adjustment-to-bothersome-pain-in-young-people-with-physical-disabilities
#20
Jordi Miró, Rocío de la Vega, Kevin J Gertz, Mark P Jensen, Joyce M Engel
PURPOSE: Family social support and parental solicitous responses have been hypothesised to play an important role in paediatric pain. However, research testing the hypothesised associations between these social domains and measures of adjustment to pain in youths with disabilities and chronic pain is non-existent. METHODS: About 111 youths with physical disabilities and bothersome pain were interviewed and asked to complete measures of average pain intensity, pain interference, family social support, parent solicitous responding, and catastrophising...
November 12, 2017: Disability and Rehabilitation
keyword
keyword
59196
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"