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J Vega

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https://www.readbyqxmd.com/read/27906962/population-density-climate-variables-and-poverty-synergistically-structure-spatial-risk-in-urban-malaria-in-india
#1
Mauricio Santos-Vega, Menno J Bouma, Vijay Kohli, Mercedes Pascual
BACKGROUND: The world is rapidly becoming urban with the global population living in cities projected to double by 2050. This increase in urbanization poses new challenges for the spread and control of communicable diseases such as malaria. In particular, urban environments create highly heterogeneous socio-economic and environmental conditions that can affect the transmission of vector-borne diseases dependent on human water storage and waste water management. Interestingly India, as opposed to Africa, harbors a mosquito vector, Anopheles stephensi, which thrives in the man-made environments of cities and acts as the vector for both Plasmodium vivax and Plasmodium falciparum, making the malaria problem a truly urban phenomenon...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27903777/repeated-evolution-of-viviparity-in-phrynosomatid-lizards-constrained-interspecific-diversification-in-some-life-history-traits
#2
J Jaime Zúñiga-Vega, Jesualdo A Fuentes-G, Alison G Ossip-Drahos, Emília P Martins
In vertebrates, viviparity has evolved independently multiple times, apparently increasing morphological diversification and speciation rates as a consequence. We tested whether the evolution of viviparity has also increased diversification of life-history traits by estimating evolutionary rates of lizards from the North American family Phrynosomatidae. Using modern phylogenetic comparative methods, we compared these rates between oviparous and viviparous species, and found no support for this hypothesis. Instead, we found higher evolutionary rates for oviparous species in some life-history traits...
November 2016: Biology Letters
https://www.readbyqxmd.com/read/27899635/interpro-in-2017-beyond-protein-family-and-domain-annotations
#3
Robert D Finn, Teresa K Attwood, Patricia C Babbitt, Alex Bateman, Peer Bork, Alan J Bridge, Hsin-Yu Chang, Zsuzsanna Dosztányi, Sara El-Gebali, Matthew Fraser, Julian Gough, David Haft, Gemma L Holliday, Hongzhan Huang, Xiaosong Huang, Ivica Letunic, Rodrigo Lopez, Shennan Lu, Aron Marchler-Bauer, Huaiyu Mi, Jaina Mistry, Darren A Natale, Marco Necci, Gift Nuka, Christine A Orengo, Youngmi Park, Sebastien Pesseat, Damiano Piovesan, Simon C Potter, Neil D Rawlings, Nicole Redaschi, Lorna Richardson, Catherine Rivoire, Amaia Sangrador-Vegas, Christian Sigrist, Ian Sillitoe, Ben Smithers, Silvano Squizzato, Granger Sutton, Narmada Thanki, Paul D Thomas, Silvio C E Tosatto, Cathy H Wu, Ioannis Xenarios, Lai-Su Yeh, Siew-Yit Young, Alex L Mitchell
InterPro (http://www.ebi.ac.uk/interpro/) is a freely available database used to classify protein sequences into families and to predict the presence of important domains and sites. InterProScan is the underlying software that allows both protein and nucleic acid sequences to be searched against InterPro's predictive models, which are provided by its member databases. Here, we report recent developments with InterPro and its associated software, including the addition of two new databases (SFLD and CDD), and the functionality to include residue-level annotation and prediction of intrinsic disorder...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27898710/identification-of-a-novel-inhibitory-allosteric-site-in-p38%C3%AE
#4
Patricia Gomez-Gutierrez, Pedro M Campos, Miguel Vega, Juan J Perez
In the present study, we report the discovery of a novel allosteric inhibitory site for p38α, a subclass of the mitogen-activated protein kinases (MAPK) family. The putative site was discovered after inspection of the crystallographic structure of the p38α-MK2 complex. MK2 (MAPK-activated protein kinase 2) is an interesting protein playing a dual role as modulator and substrate of p38α. This intriguing behavior is due to the ability of the two proteins to form distinctive heterodimers when p38α is phosphorylated or not...
2016: PloS One
https://www.readbyqxmd.com/read/27896568/how-can-a-good-idea-fail-basal-insulin-peglispro-ly2605541-for-the-treatment-of-type-2-diabetes
#5
REVIEW
Araceli Muñoz-Garach, María Molina-Vega, Francisco J Tinahones
INTRODUCTION: Lack of control in diabetic patients has stimulated the development of new insulin analogues. One of these was basal insulin peglispro (BIL) or LY2605541; it had a large hydrodynamic size, flat pharmacokinetic profile, half life of 2-3 days and acted preferably in the liver. METHODS: We reviewed the recent literature examining the pharmacokinetics, pharmacodynamics, efficacy and safety of BIL treatment in type 2 diabetes patients. RESULTS: The pharmacodynamic and pharmacokinetic outline of BIL seemed to have an advantage over neutral protamine Hagedorn and glargine insulins...
November 28, 2016: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/27895131/the-p-falciparum-cell-traversal-protein-for-ookinetes-and-sporozoites-as-a-candidate-for-pre-erythrocytic-and-transmission-blocking-vaccines
#6
Diego A Espinosa, Joel Vega-Rodriguez, Yevel Flores-Garcia, Amy R Noe, Christian Muñoz, Russell Coleman, Torben Bruck, Keith Haney, Alex Stevens, Diane Retallack, Jeff Allen, Thomas S Vedvick, Christopher B Fox, Steven G Reed, Randall F Howard, Ahmed M Salman, Chris J Janse, Shahid M Khan, Fidel Zavala, Gabriel M Gutierrez
Recent studies have shown that immune responses against the Cell-Traversal Protein for Plasmodium Ookinetes and Sporozoites (CelTOS) can inhibit parasite infection. While these studies provide important evidence towards the development of vaccines targeting this protein, it remains unknown whether these responses could engage the P. falciparum CelTOS in vivo. Using a newly developed rodent malaria chimeric parasite expressing the P. falciparum CelTOS (PfCelTOS), we evaluated the protective effect of in vivo immune responses elicited by vaccination and assessed the neutralizing capacity of monoclonal antibodies specific against PfCelTOS...
November 28, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27890719/casting-a-smaller-net-into-a-bigger-donor-pool-a-single-center-s-experience-with-the-new-kidney-allocation-system
#7
Julie A Houp, Karl P Schillinger, Andrew J Eckstein, Renato M Vega, Niraj M Desai, Bonnie E Lonze, Annette M Jackson
The new Kidney Allocation System (KAS) provides additional allocation points for candidates with broad HLA sensitization in an effort to increase transplant rates for this underserved population. Following the implementation of KAS, our center lowered the HLA antibody threshold for listing unacceptable antigens from a cytotoxicity crossmatch level to a flow cytometric crossmatch level increasing Calculated Panel Reactive Antibody (CPRA) values and allocation points, yet restricting acceptable donor HLA phenotypes...
November 24, 2016: Human Immunology
https://www.readbyqxmd.com/read/27890566/management-of-interruptions-to-fractionated-radiotherapy-treatments-four-and-a-half-years-of-experience
#8
J M de la Vega, B Ríos, J Torres Del Río, R Guerrero, I Castillo, D Guirado
BACKGROUND AND PURPOSE: The study objective was to report our four-and-a half years experience (March 1 2011-August 15 2015) of a program to manage interruptions in fractionated radiotherapy treatments. METHODS: A program was developed, based on a specific database, to manage treatment interruptions. Benefits of the program were analyzed in reference to previously published data. Analysis was also performed of two measures to reduce OTT prolongation and improve treatment outcomes: working on public holidays and conducting treatment unit maintenance on Saturdays...
November 24, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27887591/a-prospective-cohort-study-to-assess-seroprevalence-incidence-knowledge-attitudes-and-practices-willingness-to-pay-for-vaccine-and-related-risk-factors-in-dengue-in-a-high-incidence-setting
#9
Ruth Aralí Martínez-Vega, Alfonso J Rodriguez-Morales, Yalil Tomás Bracho-Churio, Mirley Enith Castro-Salas, Fredy Galvis-Ovallos, Ronald Giovanny Díaz-Quijano, María Lucrecia Luna-González, Jaime E Castellanos, José Ramos-Castañeda, Fredi Alexander Diaz-Quijano
BACKGROUND: Dengue is one of the most important vector-borne diseases in the world, causing significant morbidity and economic impact. In Colombia, dengue is a major public health problem. Departments of La Guajira, Cesar and Magdalena are dengue endemic areas. The objective of this research is to determine the seroprevalence and the incidence of dengue virus infection in the participating municipalities from these Departments, and also establish the association between individual and housing factors and vector indices with seroprevalence and incidence...
November 25, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27885812/a-whole-animal-chemical-screen-approach-to-identify-modifiers-of-intestinal-neutrophilic-inflammation
#10
Stefan H Oehlers, Maria Vega Flores, Christopher J Hall, Liuyang Wang, Dennis C Ko, Kathryn E Crosier, Philip S Crosier
By performing two high-content small molecule screens on DSS- and TNBS-induced zebrafish enterocolitis models of inflammatory bowel disease, we have identified novel anti-inflammatory drugs from the John Hopkins Clinical Compound Library that suppress neutrophilic inflammation. Live imaging of neutrophil distribution was used to assess the level of acute inflammation and concurrently screen for off-target drug effects. Supporting the validity of our screening strategy, most of the anti-inflammatory drug hits were known antibiotics or anti-inflammatory agents...
November 25, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27875099/the-rhob-small-gtpase-in-physiology-and-disease
#11
Francisco M Vega, Anne J Ridley
RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique C-terminal region is subject to specific post-translational modifications that confer different localization and functions to RhoB. Apart from the common role with RhoA and RhoC in actin organization and cell migration, RhoB is also implicated in a variety of other cellular processes including membrane trafficking, cell proliferation, DNA-repair and apoptosis. RhoB is not an essential gene in mice, but it is implicated in several physiological and pathological processes...
November 22, 2016: Small GTPases
https://www.readbyqxmd.com/read/27875011/characterization-of-tin-ethylene-glycol-solar-nanofluids-synthesized-by-laser
#12
Omar Torres-Mendieta, Rosa Mondragron, Verónica Puerto-Belda, Omel Mendoza-Yero, Jesús Lancis, J Enrique Bolivar, Gladys Mínguez-Vega
Solar energy is extended over wide geographical areas and is becoming an essential tool to keep the ever-increasing demand of energy with minimal environmental impact. A solar nanofluid is a novel solar receiver concept for efficient harvesting of solar radiation based on volumetric absorption of directly irradiated nanoparticles in a heat transfer fluid. Herein, the fabrication of a solar nanofluid by pulsed laser ablation in liquids was explored. This study was conducted with the ablation of bulk tin immersed in ethylene glycol with a femtosecond laser...
November 22, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27874267/human-digital-meissner-corpuscles-display-immunoreactivity-for-the-multifunctional-ion-channels-trpc6-and-trpv4
#13
P Alonso-González, R Cabo, I San José, A Gago, I C Suazo, O García-Suárez, J Cobo, J A Vega
Ion channels are at the basis of the sensory processes including mechanosensing. Some members of the transient receptor (TRP) ion channel superfamily have been proposed as mechanosensors, but their putative role in mechanotransduction is controversial. Among them there are TRP canonical 6 (TRPC6) and TRP vanilloid 4 (TRPV4) ion channels, which are known to cooperate in mechanical hyperalgesia. Here we investigated the occurrence, distribution and possible co-localization of TRPC6 and TRPV4 in human digital Meissner sensory corpuscles using immunohistochemistry and double immunofluorescence (associate with markers for specific corpuscular constituents)...
November 22, 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27855929/physicochemical-properties-of-nixtamalized-corn-flours-with-and-without-germ
#14
Lineth J Vega Rojas, Isela Rojas Molina, Elsa Gutiérrez Cortez, Natalia Rincón Londoño, Andrés A Acosta Osorio, Alicia Del Real López, Mario E Rodríguez García
This research studied the influence of the germ components on the physicochemical properties of cooked corn and nixtamalized corn flours as a function of the calcium hydroxide content (from 0 to 2.1 w/w) and steeping time (between 0 and 9h). A linear relationship was found between calcium content in germ and steeping time used during nixtamalization process. X-ray diffraction analysis showed that calcium carbonate is formed into the germ structure to 2.1 w/w of calcium hydroxide and 9h steeping time. The presence of the germ improves the development of peak viscosity in flours, and it is related to the increases in calcium concentration in germ and the formation of amylose-lipid complexes...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27853985/a-definition-for-aggressive-disease-in-patients-with-her-2-negative-metastatic-breast-cancer-an-expert-consensus-of-the-spanish-society-of-medical-oncology-seom
#15
REVIEW
A González, A Lluch, E Aba, J Albanell, A Antón, I Álvarez, F Ayala, A Barnadas, L Calvo, E Ciruelos, J Cortés, J de la Haba, J M López-Vega, E Martínez, M Muñoz, I Peláez, A Redondo, Á Rodríguez, C A Rodríguez, A Ruíz, A Llombart
PURPOSE: To converge on an expert opinion to define aggressive disease in patients with HER2-negative mBC using a modified Delphi methodology. METHODS: A panel of 21 breast cancer experts from the Spanish Society of Medical Oncology agreed upon a survey which comprised 47 questions that were grouped into three sections: relevance for defining aggressive disease, aggressive disease criteria and therapeutic goals. Answers were rated using a 9-point Likert scale of relevance or agreement...
November 16, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27820794/epidemiological-differences-between-localised-and-non-localised-low-back-pain
#16
David Coggon, Georgia Ntani, Karen Walker-Bone, Keith T Palmer, Vanda E Felli, Raul Harari, Lope H Barrero, Sarah A Felknor, David Gimeno, Anna Cattrell, Sergio Vargas-Prada, Matteo Bonzini, Eleni Solidaki, Eda Merisalu, Rima R Habib, Farideh Sadeghian, M Masood Kadir, Sudath Sp Warnakulasuriya, Ko Matsudaira, Busisiwe Nyantumbu, Malcolm R Sim, Helen Harcombe, Ken Cox, Leila M M Sarquis, Maria H Marziale, Florencia Harari, Rocio Freire, Natalia Harari, Magda V Monroy, Leonardo A Quintana, Marianela Rojas, E Clare Harris, Consol Serra, J Miguel Martinez, George Delclos, Fernando G Benavides, Michele Carugno, Marco M Ferrario, Angela C Pesatori, Leda Chatzi, Panos Bitsios, Manolis Kogevinas, Kristel Oha, Tiina Freimann, Ali Sadeghian, Roshini J Peiris-John, Nalini Sathiakumar, A Rajitha Wickremasinghe, Noriko Yoshimura, Helen L Kelsall, Victor C W Hoe, Donna M Urquhart, Sarah Derrett, David McBride, Peter Herbison, Andrew Gray, Eduardo J Salazar Vega
STUDY DESIGN: Cross-sectional survey with longitudinal follow-up OBJECTIVES.: To test the hypothesis that pain which is localised to the low back differs epidemiologically from that which occurs simultaneously or close in time to pain at other anatomical sites SUMMARY OF BACKGROUND DATA.: Low back pain (LBP) often occurs in combination with other regional pain, with which it shares similar psychological and psychosocial risk factors. However, few previous epidemiological studies of LBP have distinguished pain that is confined to the low back from that which occurs as part of a wider distribution of pain...
November 4, 2016: Spine
https://www.readbyqxmd.com/read/27805046/natural-resistance-to-meningococcal-disease-related-to-cfh-loci-meta-analysis-of-genome-wide-association-studies
#17
Federico Martinón-Torres, Eileen Png, Chiea Chuen Khor, Sonia Davila, Victoria J Wright, Kar Seng Sim, Ana Vega, Laura Fachal, David Inwald, Simon Nadel, Enitan D Carrol, Nazareth Martinón-Torres, Sonia Marcos Alonso, Angel Carracedo, Elvira Morteruel, Julio López-Bayón, Andrés Concha Torre, Cristina Calvo Monge, Pilar Azcón González de Aguilar, Elisabeth Esteban Torné, María Del Carmen Martínez-Padilla, José María Martinón-Sánchez, Michael Levin, Martin L Hibberd, Antonio Salas
Meningococcal disease (MD) remains an important infectious cause of life threatening infection in both industrialized and resource poor countries. Genetic factors influence both occurrence and severity of presentation, but the genes responsible are largely unknown. We performed a genome-wide association study (GWAS) examining 5,440,063 SNPs in 422 Spanish MD patients and 910 controls. We then performed a meta-analysis of the Spanish GWAS with GWAS data from the United Kingdom (combined cohorts: 897 cases and 5,613 controls; 4,898,259 SNPs)...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27804880/snake-venom-peptides-and-low-mass-proteins-molecular-tools-and-therapeutic-agents
#18
J R Almeida L M Resende, R K Watanabe, V C Corassola, S Huancahuire-Vega, C A da S Caldeira, A Coutinho-Neto, A M Soares, N Vale, P A de C Gomes, S Marangoni, L de A Calderon, S L Da Silva
Snake venoms are natural sources of biologically active molecules that are able to act selectively and specifically on different cellular targets, modulating physiological functions. Thus, these mixtures, composed mainly of proteins and peptides, provide ample and challenging opportunities and a diversified molecular architecture to design and develop tools and agents of scientific and therapeutic interest. Among these components, peptides and small proteins play diverse roles in numerous physiological processes, exerting a wide range of pharmacological activities, such as antimicrobial, antihypertensive, analgesic, antitumor, analgesic, among others...
October 28, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27799148/deregulated-expression-of-hdac9-in-b-cells-promotes-development-of-lymphoproliferative-disease-and-lymphoma
#19
V S Gil, G Bhagat, L Howell, J Zhang, C H Kim, S Stengel, F Vega, A Zelent, K Petrie
Histone Deacetylase 9 (HDAC9) is expressed in B-cells and its overexpression has been observed in B-lymphoproliferative disorders and B-cell non-Hodgkin lymphomas (B-NHL). We examined HDAC9 protein expression and copy number alterations in primary B-NHL samples, identifying high HDAC9 expression among various lymphoma entities and HDAC9 copy number gains in 50% of diffuse large B-cell lymphoma (DLBCL). To study the role of HDAC9 in lymphomagenesis we generated a genetically engineered mouse (GEM) model that constitutively expressed an HDAC9 transgene throughout B-cell development under the control of the immunoglobulin heavy chain (IgH) enhancer (Eμ)...
October 28, 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/27795386/evaluation-of-the-carba-np-test-in-oregon-2013
#20
Karim E Morey, Robert Vega, P Maureen Cassidy, Genevieve L Buser, Jaipreet K Rayar, Jeffrey A Myers, Scott J Weissman, Zintars G Beldavs, Christopher D Pfeiffer
Carbapenem-resistant Enterobacteriaceae (CRE) are an urgent public health threat. We evaluated the capacity of the Carba NP test to detect carbapenemase production in 206 isolates: 143 Enterobacteriaceae identified by Oregon's CRE surveillance in 2013 and 63 known carbapenemase-positive organisms. Overall, test sensitivity and specificity were 89% (59/66; 95% CI 81-97%) and 100% (140/140; 95% CI 98-100%), respectively. All KPC, NDM-1, VIM, and IMP-producers but no (0/7) OXA-48-like strains were Carba NP-positive prior to a post-hoc protocol modification...
October 17, 2016: Antimicrobial Agents and Chemotherapy
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