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J Vega

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https://www.readbyqxmd.com/read/29466364/abnormalities-in-gray-matter-volume-in-patients-with-borderline-personality-disorder-and-their-relation-to-lifetime-depression-a-vbm-study
#1
Salvatore Aguilar-Ortiz, Pilar Salgado-Pineda, Josep Marco-Pallarés, Juan C Pascual, Daniel Vega, Joaquim Soler, Cristina Brunel, Ana Martin-Blanco, Angel Soto, Joan Ribas, Teresa Maristany, Salvador Sarró, Raymond Salvador, Antoni Rodríguez-Fornells, Edith Pomarol-Clotet, Peter J McKenna
BACKGROUND: Structural imaging studies of borderline personality disorder (BPD) have found regions of reduced cortical volume, but these have varied considerably across studies. Reduced hippocampus and amygdala volume have also been a regular finding in studies using conventional volumetric measurement. How far comorbid major depression, which is common in BPD and can also affect in brain structure, influences the findings is not clear. METHODS: Seventy-six women with BPD and 76 matched controls were examined using whole-brain voxel-based morphometry (VBM)...
2018: PloS One
https://www.readbyqxmd.com/read/29466337/the-beaker-phenomenon-and-the-genomic-transformation-of-northwest-europe
#2
Iñigo Olalde, Selina Brace, Morten E Allentoft, Ian Armit, Kristian Kristiansen, Thomas Booth, Nadin Rohland, Swapan Mallick, Anna Szécsényi-Nagy, Alissa Mittnik, Eveline Altena, Mark Lipson, Iosif Lazaridis, Thomas K Harper, Nick Patterson, Nasreen Broomandkhoshbacht, Yoan Diekmann, Zuzana Faltyskova, Daniel Fernandes, Matthew Ferry, Eadaoin Harney, Peter de Knijff, Megan Michel, Jonas Oppenheimer, Kristin Stewardson, Alistair Barclay, Kurt Werner Alt, Corina Liesau, Patricia Ríos, Concepción Blasco, Jorge Vega Miguel, Roberto Menduiña García, Azucena Avilés Fernández, Eszter Bánffy, Maria Bernabò-Brea, David Billoin, Clive Bonsall, Laura Bonsall, Tim Allen, Lindsey Büster, Sophie Carver, Laura Castells Navarro, Oliver E Craig, Gordon T Cook, Barry Cunliffe, Anthony Denaire, Kirsten Egging Dinwiddy, Natasha Dodwell, Michal Ernée, Christopher Evans, Milan Kuchařík, Joan Francès Farré, Chris Fowler, Michiel Gazenbeek, Rafael Garrido Pena, María Haber-Uriarte, Elżbieta Haduch, Gill Hey, Nick Jowett, Timothy Knowles, Ken Massy, Saskia Pfrengle, Philippe Lefranc, Olivier Lemercier, Arnaud Lefebvre, César Heras Martínez, Virginia Galera Olmo, Ana Bastida Ramírez, Joaquín Lomba Maurandi, Tona Majó, Jacqueline I McKinley, Kathleen McSweeney, Balázs Gusztáv Mende, Alessandra Mod, Gabriella Kulcsár, Viktória Kiss, András Czene, Róbert Patay, Anna Endrődi, Kitti Köhler, Tamás Hajdu, Tamás Szeniczey, János Dani, Zsolt Bernert, Maya Hoole, Olivia Cheronet, Denise Keating, Petr Velemínský, Miroslav Dobeš, Francesca Candilio, Fraser Brown, Raúl Flores Fernández, Ana-Mercedes Herrero-Corral, Sebastiano Tusa, Emiliano Carnieri, Luigi Lentini, Antonella Valenti, Alessandro Zanini, Clive Waddington, Germán Delibes, Elisa Guerra-Doce, Benjamin Neil, Marcus Brittain, Mike Luke, Richard Mortimer, Jocelyne Desideri, Marie Besse, Günter Brücken, Mirosław Furmanek, Agata Hałuszko, Maksym Mackiewicz, Artur Rapiński, Stephany Leach, Ignacio Soriano, Katina T Lillios, João Luís Cardoso, Michael Parker Pearson, Piotr Włodarczak, T Douglas Price, Pilar Prieto, Pierre-Jérôme Rey, Roberto Risch, Manuel A Rojo Guerra, Aurore Schmitt, Joël Serralongue, Ana Maria Silva, Václav Smrčka, Luc Vergnaud, João Zilhão, David Caramelli, Thomas Higham, Mark G Thomas, Douglas J Kennett, Harry Fokkens, Volker Heyd, Alison Sheridan, Karl-Göran Sjögren, Philipp W Stockhammer, Johannes Krause, Ron Pinhasi, Wolfgang Haak, Ian Barnes, Carles Lalueza-Fox, David Reich
From around 2750 to 2500 bc, Bell Beaker pottery became widespread across western and central Europe, before it disappeared between 2200 and 1800 bc. The forces that propelled its expansion are a matter of long-standing debate, and there is support for both cultural diffusion and migration having a role in this process. Here we present genome-wide data from 400 Neolithic, Copper Age and Bronze Age Europeans, including 226 individuals associated with Beaker-complex artefacts. We detected limited genetic affinity between Beaker-complex-associated individuals from Iberia and central Europe, and thus exclude migration as an important mechanism of spread between these two regions...
February 21, 2018: Nature
https://www.readbyqxmd.com/read/29465476/idiopathic-pulmonary-fibrosis-a-guide-for-nurse-practitioners
#3
Michelle Vega-Olivo, Gerard J Criner
Idiopathic pulmonary fibrosis (IPF) is a rare disease characterized by decline in lung function, dyspnea, and cough. The clinical course of IPF is variable and unpredictable. Early referral to specialists is key to ensure timely and accurate diagnosis. Two antifibrotic drugs (nintedanib and pirfenidone) have been approved for the treatment of IPF.
February 19, 2018: Nurse Practitioner
https://www.readbyqxmd.com/read/29456452/factors-associated-with-no-2-and-no-x-concentration-gradients-near-a-highway
#4
J Richmond-Bryant, M G Snyder, R C Owen, S Kimbrough
The objective of this research is to learn how the near-road gradient, in which NO2 and NOX (NO + NO2 ) concentrations are elevated, varies with changes in meteorological and traffic variables. Measurements of NO2 and NOX were obtained east of I-15 in Las Vegas and fit to functions whose slopes (dCNO2 /dx and dCNOX /dx, respectively) characterize the size of the near-road zone where NO2 and NOX concentrations from mobile sources on the highway are elevated. These metrics were used to learn about the near-road gradient by modeling dCNO2 /dx and dCNOX /dx as functions of meteorological variables (e...
November 21, 2017: Atmospheric Environment
https://www.readbyqxmd.com/read/29455526/structure-based-optimization-strategies-for-g-protein-coupled-receptor-gpcr-allosteric-modulators-a-case-study-from-analyses-of-new-metabotropic-glutamate-receptor-5-mglu-5-x-ray-structures
#5
John Christopher, Zoltán Orgován, Miles Congreve, Andrew S Dore, James C Errey, Fiona H Marshall, Jonathan S Mason, Krzysztof Okrasa, Prakash Rucktooa, Maria J Serrano-Vega, György G Ferenczy, Gyorgy M Keseru
Two interesting new X-ray structures of negative allosteric modulator (NAM) ligands for the mGlu5 receptor, M-MPEP (3) and fenobam (4), are reported. The new structures show how the binding of the ligands induces different receptor water channel conformations to previously published structures. The structure of fenobam, where a urea replaces the acetylenic linker in M-MPEP and mavoglurant, reveals a binding mode where the ligand is rotated by 180º compared to a previously proposed docking model. The need for multiple ligand structures for accurate GPCR structure-based drug design is demonstrated by the different growing vectors identified for the head groups of M-MPEP and mavoglurant and by the unexpected water mediated receptor interactions of a new chemotype represented by fenobam...
February 18, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29451298/micro-computed-tomography-visualization-of-the-vestigial-alimentary-canal-in-adult-oestrid-flies
#6
D Martín-Vega, A Garbout, F Ahmed, L M Ferrer, J Lucientes, D D Colwell, M J R Hall
Oestrid flies (Diptera: Oestridae) do not feed during the adult stage as they acquire all necessary nutrients during the parasitic larval stage. The adult mouthparts and digestive tract are therefore frequently vestigial; however, morphological data on the alimentary canal in adult oestrid flies are scarce and a proper visualization of this organ system within the adult body is lacking. The present work visualizes the morphology of the alimentary canal in adults of two oestrid species, Oestrus ovis L. and Hypoderma lineatum (de Villiers), with the use of non-invasive micro-computed tomography (micro-CT) and compares it with the highly developed alimentary canal of the blow fly Calliphora vicina Robineau-Desvoidy (Diptera: Calliphoridae)...
February 16, 2018: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/29446198/mutational-spectrum-in-a-worldwide-study-of-29-700-families-with-brca1-or-brca2-mutations
#7
Timothy R Rebbeck, Tara M Friebel, Eitan Friedman, Ute Hamann, Dezheng Huo, Ava Kwong, Edith Olah, Olufunmilayo I Olopade, Angela R Solano, Soo-Hwang Teo, Mads Thomassen, Jeffrey N Weitzel, T L Chan, Fergus J Couch, David E Goldgar, Torben A Kruse, Edenir Inêz Palmero, Sue Kyung Park, Diana Torres, Elizabeth J van Rensburg, Lesley McGuffog, Michael T Parsons, Goska Leslie, Cora M Aalfs, Julio Abugattas, Julian Adlard, Simona Agata, Kristiina Aittomäki, Lesley Andrews, Irene L Andrulis, Adalgeir Arason, Norbert Arnold, Banu K Arun, Ella Asseryanis, Leo Auerbach, Jacopo Azzollini, Judith Balmaña, Monica Barile, Rosa B Barkardottir, Daniel Barrowdale, Javier Benitez, Andreas Berger, Raanan Berger, Amie M Blanco, Kathleen R Blazer, Marinus J Blok, Valérie Bonadona, Bernardo Bonanni, Angela R Bradbury, Carole Brewer, Bruno Buecher, Saundra S Buys, Trinidad Caldes, Almuth Caliebe, Maria A Caligo, Ian Campbell, Sandrine Caputo, Jocelyne Chiquette, Wendy K Chung, Kathleen B M Claes, J Margriet Collée, Jackie Cook, Rosemarie Davidson, Miguel de la Hoya, Kim De Leeneer, Antoine de Pauw, Capucine Delnatte, Orland Diez, Yuan Chun Ding, Nina Ditsch, Susan M Domchek, Cecilia M Dorfling, Carolina Velazquez, Bernd Dworniczak, Jacqueline Eason, Douglas F Easton, Ros Eeles, Hans Ehrencrona, Bent Ejlertsen, Christoph Engel, Stefanie Engert, D Gareth Evans, Laurence Faivre, Lidia Feliubadaló, Sandra Fert Ferrer, Lenka Foretova, Jeffrey Fowler, Debra Frost, Henrique C R Galvão, Patricia A Ganz, Judy Garber, Marion Gauthier-Villars, Andrea Gehrig, Anne-Marie Gerdes, Paul Gesta, Giuseppe Giannini, Sophie Giraud, Gord Glendon, Andrew K Godwin, Mark H Greene, Jacek Gronwald, Angelica Gutierrez-Barrera, Eric Hahnen, Jan Hauke, Alex Henderson, Julia Hentschel, Frans B L Hogervorst, Ellen Honisch, Evgeny N Imyanitov, Claudine Isaacs, Louise Izatt, Angel Izquierdo, Anna Jakubowska, Paul James, Ramunas Janavicius, Uffe Birk Jensen, Esther M John, Vijai Joseph, Katarzyna Kaczmarek, Beth Y Karlan, Karin Kast, KConFab Investigators, Sung-Won Kim, Irene Konstantopoulou, Jacob Korach, Yael Laitman, Adriana Lasa, Christine Lasset, Conxi Lázaro, Annette Lee, Min Hyuk Lee, Jenny Lester, Fabienne Lesueur, Annelie Liljegren, Noralane M Lindor, Michel Longy, Jennifer T Loud, Karen H Lu, Jan Lubinski, Eva Machackova, Siranoush Manoukian, Véronique Mari, Cristina Martínez-Bouzas, Zoltan Matrai, Noura Mebirouk, Hanne E J Meijers-Heijboer, Alfons Meindl, Arjen R Mensenkamp, Ugnius Mickys, Austin Miller, Marco Montagna, Kirsten B Moysich, Anna Marie Mulligan, Jacob Musinsky, Susan L Neuhausen, Heli Nevanlinna, Joanne Ngeow, Huu Phuc Nguyen, Dieter Niederacher, Henriette Roed Nielsen, Finn Cilius Nielsen, Robert L Nussbaum, Kenneth Offit, Anna Öfverholm, Kai-Ren Ong, Ana Osorio, Laura Papi, Janos Papp, Barbara Pasini, Inge Sokilde Pedersen, Ana Peixoto MSc, Nina Peruga MSc, Paolo Peterlongo, Esther Pohl, Nisha Pradhan Ba, Karolina Prajzendanc, Fabienne Prieur, Pascal Pujol, Paolo Radice, Susan J Ramus, Johanna Rantala, Muhammad Usman Rashid, Kerstin Rhiem, Mark Robson, Gustavo C Rodriguez, Mark T Rogers, Vilius Rudaitis, Ane Y Schmidt, Rita Katharina Schmutzler, Leigha Senter, Payal D Shah, Priyanka Sharma, Lucy E Side, Jacques Simard, Christian F Singer, Anne-Bine Skytte, Thomas P Slavin, Katie Snape, Hagay Sobol, Melissa Southey, Linda Steele, Doris Steinemann, Grzegorz Sukiennicki, Christian Sutter, Csilla I Szabo, Yen Y Tan, Manuel R Teixeira, Mary Beth Terry, Alex Teulé, Abigail Thomas, Darcy L Thull, Marc Tischkowitz, Silvia Tognazzo, Amanda Ewart Toland, Sabine Topka, Alison H Trainer, Nadine Tung, Christi J van Asperen, Annemieke H van der Hout, Lizet E van der Kolk, Rob B van der Luijt, Mattias Van Heetvelde, Liliana Varesco, Raymonda Varon-Mateeva, Ana Vega, Cynthia Villarreal-Garza, Anna von Wachenfeldt, Lisa Walker, Shan Wang-Gohrke, Barbara Wappenschmidt, Bernhard H F Weber, Drakoulis Yannoukakos, Sook-Yee Yoon, Cristina Zanzottera, Jamal Zidan, Kristin K Zorn, Christina G Hutten Selkirk, Peter J Hulick, Georgia Chenevix-Trench, Amanda B Spurdle, Antonis C Antoniou, Katherine L Nathanson
The prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been reported in single populations, with the majority of reports focused on Caucasians in Europe and North America. The Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) has assembled data on 18,435 families with BRCA1 mutations and 11,351 families with BRCA2 mutations ascertained from 69 centers in 49 countries on 6 continents. This study comprehensively describes the characteristics of the 1,650 unique BRCA1 and 1,731 unique BRCA2 deleterious (disease-associated) mutations identified in the CIMBA database...
February 15, 2018: Human Mutation
https://www.readbyqxmd.com/read/29446083/development-and-clinical-characterization-of-a-novel-2041-liquid-filled-ionization-chambers-array-for-high-resolution-verification-of-radiotherapy-treatments
#8
L Brualla-González, A Vázquez-Luque, M Zapata, D M González-Castaño, V Luna-Vega, J Guiu-Souto, J Prieto-Pena, T García, D Granero, A Vicedo, J Rosellò, M Pombar, F Gómez, J Pardo-Montero
PURPOSE: To present a novel 2041 liquid-filled ionization chamber array for high-resolution verification of radiotherapy treatments. MATERIALS AND METHODS: The prototype has 2041 ionization chambers of 2.5×2.5 mm2 area filled with isooctane. The detection elements are arranged in a central square grid of 43×43, totally covering an area of 107.5×107.5 mm2 . The central inline and crossline are extended to 227 mm and the diagonals to 321 mm in order to be able to perform profile measurements of large fields...
February 15, 2018: Medical Physics
https://www.readbyqxmd.com/read/29435310/risk-of-histologic-barrett-s-esophagus-between-african-americans-and-non-hispanic-whites-a-meta-analysis
#9
Ahmad Alkaddour, Carlos Palacio, Kenneth J Vega
Background: Barrett's esophagus (BE) is rare in African Americans (AA). However, the risk difference magnitude in histologic BE prevalence between AA and non-Hispanic whites (nHw) has not been quantified to date. Objective: The objective of this article is to determine the degree of histologic BE risk difference between AA and nHw. Methods: PubMed, Web of Science and EMBASE were searched for studies reporting histologic BE in AA/nHw for inclusion...
February 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29433769/endoscopic-submucosal-dissection-as-treatment-for-early-gastric-cancer-experience-at-two-centers-in-lima-peru
#10
J A Chirinos Vega, G Vargas, C Alcántara, J Zapata
INTRODUCTION AND AIMS: The aim of the present study was to evaluate the feasibility of endoscopic submucosal dissection (ESD) and determine the clinical and pathologic characteristics of early gastric cancers and premalignant lesions treated with that technique at the Hospital Nacional of the Department of Health and a private clinic in Lima, Peru. MATERIAL AND METHODS: A descriptive study of all pre-malignant and malignant gastric lesions treated with ESD at the Gastroenterology Service of the Hospital Arzobispo Loayza and the Clínica Angloamericana was conducted within the time frame of January 2012 and January 2017...
February 9, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29429722/ultrasound-assisted-crystallization-of-lactose-in-the-presence-of-whey-proteins-and-%C3%AE%C2%BA-carrageenan
#11
Yanira I Sánchez-García, Karen S García-Vega, Martha Y Leal-Ramos, Ivan Salmeron, Néstor Gutiérrez-Méndez
The conventional process of lactose crystallization is prolonged, hardly controllable and the crystals have low quality. In this work, the effect of ultrasound on the crystallization of lactose in an aqueous system was assessed. Additionally, it was studied how the presence of whey proteins (which are a common impurity) and κ-carrageenan (that possess high water-binding capacity) could modify the process of lactose crystallization. Lactose solutions at 25% were sonicated in a continuous flow chamber at two different energy densities (9 and 50 J mL-1) before the start of crystallization...
April 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29422223/which-are-the-colors-of-the-dress-review-of-an-atypical-optic-illusion
#12
J González Martín-Moro, F Prieto Garrido, F Gómez Sanz, I Fuentes Vega, M Castro Rebollo, P Moreno Martín
OBJECTIVE: In 2015 the picture of a dress went viral in the social media. A significant proportion of the population saw it as golden and white (G&W), while another significant proportion saw it as blue and black (B&B). The aim of this article is to review the related literature. MATERIAL AND METHODS: Bibliographic search conducted in Pubmed and Google. The algorithm used was: (color OR colour) AND (dress OR #thedress). The search was limited to the years 2015-2017...
February 5, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29422099/applying-the-results-based-management-framework-to-the-cerca-multi-component-project-in-adolescent-sexual-and-reproductive-health-a-retrospective-analysis
#13
Kathya Cordova-Pozo, Andrea J Hoopes, Freddy Cordova, Bernardo Vega, Zoyla Segura, Arnold Hagens
BACKGROUND: Adolescent sexual and reproductive health (SRH), problems such as unplanned pregnancies are complex and multifactorial, thus requiring multifaceted prevention interventions. Evaluating the impact of such interventions is important to ensure efficiency, effectiveness and accountability for project funders and community members. In this study, we propose Results Based Management (RBM) as a framework for project management, using the Community Embedded Reproductive Health Care for Adolescents (CERCA) as a case study for RBM...
February 8, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29410788/experiencing-el-ni%C3%A3-o-conditions-during-early-life-reduces-recruiting-probabilities-but-not-adult-survival
#14
Sergio Ancona, J Jaime Zúñiga-Vega, Cristina Rodríguez, Hugh Drummond
In wild long-lived animals, analysis of impacts of stressful natal conditions on adult performance has rarely embraced the entire age span, and the possibility that costs are expressed late in life has seldom been examined. Using 26 years of data from 8541 fledglings and 1310 adults of the blue-footed booby (Sula nebouxii), a marine bird that can live up to 23 years, we tested whether experiencing the warm waters and food scarcity associated with El Niño in the natal year reduces recruitment or survival over the adult lifetime...
January 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29404461/cat-2003-a-novel-sterol-regulatory-element-binding-protein-inhibitor-that-reduces-steatohepatitis-plasma-lipids-and-atherosclerosis-in-apolipoprotein-e-3-leiden-mice
#15
Michael Zimmer, Pradeep Bista, Ericka L Benson, Diana Y Lee, Feng Liu, Dominic Picarella, Rick B Vega, Chi B Vu, Maisy Yeager, Min Ding, Guosheng Liang, Jay D Horton, Robert Kleemann, Teake Kooistra, Martine C Morrison, Peter Y Wielinga, Jill C Milne, Michael R Jirousek, Andrew J Nichols
CAT-2003 is a novel conjugate of eicosapentaenoic acid (EPA) and niacin designed to be hydrolyzed by fatty acid amide hydrolase to release EPA inside cells at the endoplasmic reticulum. In cultured liver cells, CAT-2003 blocked the maturation of sterol regulatory element-binding protein (SREBP)-1 and SREBP-2 proteins and decreased the expression of multiple SREBP target genes, including HMGCR and PCSK9 . Consistent with proprotein convertase subtilisin/kexin type 9 (PCSK9) reduction, both low-density lipoprotein receptor protein at the cell surface and low-density lipoprotein particle uptake were increased...
June 2017: Hepatology communications
https://www.readbyqxmd.com/read/29389893/an-intraoperative-visualization-system-using-hyperspectral-imaging-to-aid-in-brain-tumor-delineation
#16
Himar Fabelo, Samuel Ortega, Raquel Lazcano, Daniel Madroñal, Gustavo M Callicó, Eduardo Juárez, Rubén Salvador, Diederik Bulters, Harry Bulstrode, Adam Szolna, Juan F Piñeiro, Coralia Sosa, Aruma J O'Shanahan, Sara Bisshopp, María Hernández, Jesús Morera, Daniele Ravi, B Ravi Kiran, Aurelio Vega, Abelardo Báez-Quevedo, Guang-Zhong Yang, Bogdan Stanciulescu, Roberto Sarmiento
Hyperspectral imaging (HSI) allows for the acquisition of large numbers of spectral bands throughout the electromagnetic spectrum (within and beyond the visual range) with respect to the surface of scenes captured by sensors. Using this information and a set of complex classification algorithms, it is possible to determine which material or substance is located in each pixel. The work presented in this paper aims to exploit the characteristics of HSI to develop a demonstrator capable of delineating tumor tissue from brain tissue during neurosurgical operations...
February 1, 2018: Sensors
https://www.readbyqxmd.com/read/29388394/composition-of-gut-microbiota-in-obese-and-normal-weight-mexican-school-age-children-and-its-association-with-metabolic-traits
#17
B E López-Contreras, S Morán-Ramos, R Villarruel-Vázquez, L Macías-Kauffer, H Villamil-Ramírez, P León-Mimila, J Vega-Badillo, F Sánchez-Muñoz, L E Llanos-Moreno, A Canizalez-Román, B Del Río-Navarro, I Ibarra-González, M Vela-Amieva, T Villarreal-Molina, A Ochoa-Leyva, C A Aguilar-Salinas, S Canizales-Quinteros
BACKGROUND: Childhood obesity is a serious public health problem in Mexico. Adult gut microbiota composition has been linked to obesity, but few studies have addressed the role of gut microbiota in childhood obesity. OBJECTIVES: The aim of this study is to compare gut microbiota composition in obese and normal-weight children and to associate gut microbiota profiles with amino acid serum levels and obesity-related metabolic traits. METHODS: Microbial taxa relative abundance was determined by 16S rRNA sequencing in 67 normal-weight and 71 obese children aged 6-12 years...
December 5, 2017: Pediatric Obesity
https://www.readbyqxmd.com/read/29383696/trap1-regulates-autophagy-in-lung-cancer-cells
#18
Ines A Barbosa, Ignacio Vega-Naredo, Rute Loureiro, Ana F Branco, Rita Garcia, Patricia M Scott, Paulo J Oliveira
BACKGROUND: Expression of TRAP1, a member of the HSP90 chaperone family, has been implicated in tumor protective effects, based on differential mitochondrial localization and function. DESIGN: This work was designed to provide new insights on the pathways involved in TRAP1-provided cytoprotection on NSCLC. For this, TRAP1-depleted A549 human NSCLC cells and MRC-5 normal lung fibroblasts were produced using a siRNA approach and main cellular quality control mechanisms were investigated...
January 31, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29377274/all-oral-daa-therapy-against-hcv-in-hiv-hcv-coinfected-subjects-in-real-world-practice-madrid-core-findings
#19
Juan Berenguer, Ángela Gil-Martin, Inmaculada Jarrin, Ana Moreno, Lourdes Dominguez, Marisa Montes, Teresa Aldámiz-Echevarría, María J Téllez, Ignacio Santos, Laura Benitez, José Sanz, Pablo Ryan, Gabriel Gaspar, Beatriz Alvarez, Juan E Losa, Rafael Torres-Perea, Carlos Barros, Juan V San Martin, Sari Arponen, María Teresa de Guzmán, Raquel Monsalvo, Ana Vegas, María T Garcia-Benayas, Regino Serrano, Luis Gotuzzo, María Antonia Menendez, Luis M Belda, Eduardo Malmierca, María J Calvo, Encarnación Cruz-Martos, Juan J González-García
We evaluated treatment outcomes in a prospective registry of HIV/HCV-coinfected patients treated with interferon-free direct-acting antiviral agent (DAA)-based therapy in hospitals from the region of Madrid between November 2014 and August 2016. We assessed sustained viral response (SVR) at 12 weeks after completion of treatment and used multivariable logistic regression to identify predictors of treatment failure. We evaluated 2,369 patients, of whom 59.5% were non-cirrhotic (Non-C), 33.9% had compensated cirrhosis (Co-C), and 6...
January 29, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29371567/fungal-strategies-to-evade-the-host-immune-recognition
#20
REVIEW
Marco J Hernández-Chávez, Luis A Pérez-García, Gustavo A Niño-Vega, Héctor M Mora-Montes
The recognition of fungal cells by the host immune system is key during the establishment of a protective anti-fungal response. Even though the immune system has evolved a vast number of processes to control these organisms, they have developed strategies to fight back, avoiding the proper recognition by immune components and thus interfering with the host protective mechanisms. Therefore, the strategies to evade the immune system are as important as the virulence factors and attributes that damage the host tissues and cells...
September 23, 2017: Journal of Fungi (Basel, Switzerland)
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