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David Vega

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https://www.readbyqxmd.com/read/29471804/genetic-mapping-and-comparative-genomics-to-inform-restoration-enhancement-and-culture-of-southern-flounder-paralichthys-lethostigma
#1
Shannon J O'Leary, Christopher M Hollenbeck, Robert R Vega, John R Gold, David S Portnoy
BACKGROUND: Southern flounder, Paralichthys lethostigma, historically support a substantial fishery along the Atlantic and Gulf coasts of the southern United States. Low year-class strengths over the past few years in the western Gulf of Mexico have raised concern that spawning stocks may be overfished. Current management of the resource includes releasing hatchery-raised juveniles to restock bays and estuaries; additionally, there is a growing interest in the potential for commercial aquaculture of the species...
February 23, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29466337/the-beaker-phenomenon-and-the-genomic-transformation-of-northwest-europe
#2
Iñigo Olalde, Selina Brace, Morten E Allentoft, Ian Armit, Kristian Kristiansen, Thomas Booth, Nadin Rohland, Swapan Mallick, Anna Szécsényi-Nagy, Alissa Mittnik, Eveline Altena, Mark Lipson, Iosif Lazaridis, Thomas K Harper, Nick Patterson, Nasreen Broomandkhoshbacht, Yoan Diekmann, Zuzana Faltyskova, Daniel Fernandes, Matthew Ferry, Eadaoin Harney, Peter de Knijff, Megan Michel, Jonas Oppenheimer, Kristin Stewardson, Alistair Barclay, Kurt Werner Alt, Corina Liesau, Patricia Ríos, Concepción Blasco, Jorge Vega Miguel, Roberto Menduiña García, Azucena Avilés Fernández, Eszter Bánffy, Maria Bernabò-Brea, David Billoin, Clive Bonsall, Laura Bonsall, Tim Allen, Lindsey Büster, Sophie Carver, Laura Castells Navarro, Oliver E Craig, Gordon T Cook, Barry Cunliffe, Anthony Denaire, Kirsten Egging Dinwiddy, Natasha Dodwell, Michal Ernée, Christopher Evans, Milan Kuchařík, Joan Francès Farré, Chris Fowler, Michiel Gazenbeek, Rafael Garrido Pena, María Haber-Uriarte, Elżbieta Haduch, Gill Hey, Nick Jowett, Timothy Knowles, Ken Massy, Saskia Pfrengle, Philippe Lefranc, Olivier Lemercier, Arnaud Lefebvre, César Heras Martínez, Virginia Galera Olmo, Ana Bastida Ramírez, Joaquín Lomba Maurandi, Tona Majó, Jacqueline I McKinley, Kathleen McSweeney, Balázs Gusztáv Mende, Alessandra Mod, Gabriella Kulcsár, Viktória Kiss, András Czene, Róbert Patay, Anna Endrődi, Kitti Köhler, Tamás Hajdu, Tamás Szeniczey, János Dani, Zsolt Bernert, Maya Hoole, Olivia Cheronet, Denise Keating, Petr Velemínský, Miroslav Dobeš, Francesca Candilio, Fraser Brown, Raúl Flores Fernández, Ana-Mercedes Herrero-Corral, Sebastiano Tusa, Emiliano Carnieri, Luigi Lentini, Antonella Valenti, Alessandro Zanini, Clive Waddington, Germán Delibes, Elisa Guerra-Doce, Benjamin Neil, Marcus Brittain, Mike Luke, Richard Mortimer, Jocelyne Desideri, Marie Besse, Günter Brücken, Mirosław Furmanek, Agata Hałuszko, Maksym Mackiewicz, Artur Rapiński, Stephany Leach, Ignacio Soriano, Katina T Lillios, João Luís Cardoso, Michael Parker Pearson, Piotr Włodarczak, T Douglas Price, Pilar Prieto, Pierre-Jérôme Rey, Roberto Risch, Manuel A Rojo Guerra, Aurore Schmitt, Joël Serralongue, Ana Maria Silva, Václav Smrčka, Luc Vergnaud, João Zilhão, David Caramelli, Thomas Higham, Mark G Thomas, Douglas J Kennett, Harry Fokkens, Volker Heyd, Alison Sheridan, Karl-Göran Sjögren, Philipp W Stockhammer, Johannes Krause, Ron Pinhasi, Wolfgang Haak, Ian Barnes, Carles Lalueza-Fox, David Reich
From around 2750 to 2500 bc, Bell Beaker pottery became widespread across western and central Europe, before it disappeared between 2200 and 1800 bc. The forces that propelled its expansion are a matter of long-standing debate, and there is support for both cultural diffusion and migration having a role in this process. Here we present genome-wide data from 400 Neolithic, Copper Age and Bronze Age Europeans, including 226 individuals associated with Beaker-complex artefacts. We detected limited genetic affinity between Beaker-complex-associated individuals from Iberia and central Europe, and thus exclude migration as an important mechanism of spread between these two regions...
February 21, 2018: Nature
https://www.readbyqxmd.com/read/29460049/double-blind-study-investigating-the-effect-of-different-voice-prostheses-on-ease-of-swallowing-and-residue-post-laryngectomy
#3
Margaret M Coffey, Neil Tolley, David Howard, Mary Hickson
Voice prostheses have been examined for their effect on voice production but there is little datum on their effect on swallow function. This study investigated the difference between six commonly available voice prostheses in terms of swallowing. Laryngectomy patients had up to six voice prostheses placed in a random order over two visits. Swallowing was evaluated for each prosthesis using FEES (Fibreoptic Endoscopic Evaluation of Swallowing). After each prosthesis trial, patients self-evaluated their experience of swallowing...
February 19, 2018: Dysphagia
https://www.readbyqxmd.com/read/29446198/mutational-spectrum-in-a-worldwide-study-of-29-700-families-with-brca1-or-brca2-mutations
#4
Timothy R Rebbeck, Tara M Friebel, Eitan Friedman, Ute Hamann, Dezheng Huo, Ava Kwong, Edith Olah, Olufunmilayo I Olopade, Angela R Solano, Soo-Hwang Teo, Mads Thomassen, Jeffrey N Weitzel, T L Chan, Fergus J Couch, David E Goldgar, Torben A Kruse, Edenir Inêz Palmero, Sue Kyung Park, Diana Torres, Elizabeth J van Rensburg, Lesley McGuffog, Michael T Parsons, Goska Leslie, Cora M Aalfs, Julio Abugattas, Julian Adlard, Simona Agata, Kristiina Aittomäki, Lesley Andrews, Irene L Andrulis, Adalgeir Arason, Norbert Arnold, Banu K Arun, Ella Asseryanis, Leo Auerbach, Jacopo Azzollini, Judith Balmaña, Monica Barile, Rosa B Barkardottir, Daniel Barrowdale, Javier Benitez, Andreas Berger, Raanan Berger, Amie M Blanco, Kathleen R Blazer, Marinus J Blok, Valérie Bonadona, Bernardo Bonanni, Angela R Bradbury, Carole Brewer, Bruno Buecher, Saundra S Buys, Trinidad Caldes, Almuth Caliebe, Maria A Caligo, Ian Campbell, Sandrine Caputo, Jocelyne Chiquette, Wendy K Chung, Kathleen B M Claes, J Margriet Collée, Jackie Cook, Rosemarie Davidson, Miguel de la Hoya, Kim De Leeneer, Antoine de Pauw, Capucine Delnatte, Orland Diez, Yuan Chun Ding, Nina Ditsch, Susan M Domchek, Cecilia M Dorfling, Carolina Velazquez, Bernd Dworniczak, Jacqueline Eason, Douglas F Easton, Ros Eeles, Hans Ehrencrona, Bent Ejlertsen, Christoph Engel, Stefanie Engert, D Gareth Evans, Laurence Faivre, Lidia Feliubadaló, Sandra Fert Ferrer, Lenka Foretova, Jeffrey Fowler, Debra Frost, Henrique C R Galvão, Patricia A Ganz, Judy Garber, Marion Gauthier-Villars, Andrea Gehrig, Anne-Marie Gerdes, Paul Gesta, Giuseppe Giannini, Sophie Giraud, Gord Glendon, Andrew K Godwin, Mark H Greene, Jacek Gronwald, Angelica Gutierrez-Barrera, Eric Hahnen, Jan Hauke, Alex Henderson, Julia Hentschel, Frans B L Hogervorst, Ellen Honisch, Evgeny N Imyanitov, Claudine Isaacs, Louise Izatt, Angel Izquierdo, Anna Jakubowska, Paul James, Ramunas Janavicius, Uffe Birk Jensen, Esther M John, Vijai Joseph, Katarzyna Kaczmarek, Beth Y Karlan, Karin Kast, KConFab Investigators, Sung-Won Kim, Irene Konstantopoulou, Jacob Korach, Yael Laitman, Adriana Lasa, Christine Lasset, Conxi Lázaro, Annette Lee, Min Hyuk Lee, Jenny Lester, Fabienne Lesueur, Annelie Liljegren, Noralane M Lindor, Michel Longy, Jennifer T Loud, Karen H Lu, Jan Lubinski, Eva Machackova, Siranoush Manoukian, Véronique Mari, Cristina Martínez-Bouzas, Zoltan Matrai, Noura Mebirouk, Hanne E J Meijers-Heijboer, Alfons Meindl, Arjen R Mensenkamp, Ugnius Mickys, Austin Miller, Marco Montagna, Kirsten B Moysich, Anna Marie Mulligan, Jacob Musinsky, Susan L Neuhausen, Heli Nevanlinna, Joanne Ngeow, Huu Phuc Nguyen, Dieter Niederacher, Henriette Roed Nielsen, Finn Cilius Nielsen, Robert L Nussbaum, Kenneth Offit, Anna Öfverholm, Kai-Ren Ong, Ana Osorio, Laura Papi, Janos Papp, Barbara Pasini, Inge Sokilde Pedersen, Ana Peixoto MSc, Nina Peruga MSc, Paolo Peterlongo, Esther Pohl, Nisha Pradhan Ba, Karolina Prajzendanc, Fabienne Prieur, Pascal Pujol, Paolo Radice, Susan J Ramus, Johanna Rantala, Muhammad Usman Rashid, Kerstin Rhiem, Mark Robson, Gustavo C Rodriguez, Mark T Rogers, Vilius Rudaitis, Ane Y Schmidt, Rita Katharina Schmutzler, Leigha Senter, Payal D Shah, Priyanka Sharma, Lucy E Side, Jacques Simard, Christian F Singer, Anne-Bine Skytte, Thomas P Slavin, Katie Snape, Hagay Sobol, Melissa Southey, Linda Steele, Doris Steinemann, Grzegorz Sukiennicki, Christian Sutter, Csilla I Szabo, Yen Y Tan, Manuel R Teixeira, Mary Beth Terry, Alex Teulé, Abigail Thomas, Darcy L Thull, Marc Tischkowitz, Silvia Tognazzo, Amanda Ewart Toland, Sabine Topka, Alison H Trainer, Nadine Tung, Christi J van Asperen, Annemieke H van der Hout, Lizet E van der Kolk, Rob B van der Luijt, Mattias Van Heetvelde, Liliana Varesco, Raymonda Varon-Mateeva, Ana Vega, Cynthia Villarreal-Garza, Anna von Wachenfeldt, Lisa Walker, Shan Wang-Gohrke, Barbara Wappenschmidt, Bernhard H F Weber, Drakoulis Yannoukakos, Sook-Yee Yoon, Cristina Zanzottera, Jamal Zidan, Kristin K Zorn, Christina G Hutten Selkirk, Peter J Hulick, Georgia Chenevix-Trench, Amanda B Spurdle, Antonis C Antoniou, Katherine L Nathanson
The prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been reported in single populations, with the majority of reports focused on Caucasians in Europe and North America. The Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) has assembled data on 18,435 families with BRCA1 mutations and 11,351 families with BRCA2 mutations ascertained from 69 centers in 49 countries on 6 continents. This study comprehensively describes the characteristics of the 1,650 unique BRCA1 and 1,731 unique BRCA2 deleterious (disease-associated) mutations identified in the CIMBA database...
February 15, 2018: Human Mutation
https://www.readbyqxmd.com/read/29429741/the-nematophagous-fungus-duddingtonia-flagrans-reduces-the-gastrointestinal-parasitic-nematode-larvae-population-in-faeces-of-orally-treated-calves-maintained-under-tropical-conditions-dose-response-assessment
#5
Pedro Mendoza-de-Gives, María Eugenia López-Arellano, Liliana Aguilar-Marcelino, Sara Olazarán-Jenkins, David Reyes-Guerrero, Gabriel Ramírez-Várgas, Vicente E Vega-Murillo
This research was performed to assess the Duddingtonia flagrans chlamydospore dose/response administered in gastrointestinal parasitic nematode (GIN) naturally infected calves and its effect in reducing the GIN infective larvae (L3) population in faeces in a cattle farm in the Mexican tropics. This study was carried out at the experimental research station "Las Margaritas" in Hueytamalco Municipality, Puebla State, Mexico. Forty zebu calves, between 6 to 12 months of age were randomly distributed into four groups of ten calves each...
January 31, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29428401/exposure-to-an-obesogenic-diet-during-adolescence-leads-to-abnormal-maturation-of-neural-and-behavioral-substrates-underpinning-fear-and-anxiety
#6
Julio David Vega-Torres, Elizabeth Haddad, Jeong Bin Lee, Priya Kalyan-Masih, Wanda I Maldonado George, Leonardo López Pérez, Darla M Piñero Vázquez, Yaría Arroyo Torres, José M Santiago Santana, Andre Obenaus, Johnny D Figueroa
BACKGROUND: Post-traumatic stress disorder (PTSD) and obesity are highly prevalent in adolescents. Emerging findings from our laboratory and others are consistent with the novel hypothesis that obese individuals may be predisposed to developing PTSD. Given that aberrant fear responses are pivotal in the pathogenesis of PTSD, the objective of this study was to determine the impact of an obesogenic Western-like high-fat diet (WD) on neural substrates associated with fear. METHODS: Adolescent Lewis rats (n = 72) were fed with either the experimental WD (41...
February 8, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29410039/autophagic-dysfunction-in-papillon-lef%C3%A3-vre-syndrome-is-restored-by-recombinant-cathepsin-c-treatment
#7
Pedro Bullón, Beatriz Castejón-Vega, Lourdes Román-Malo, María Paz Jimenez-Guerrero, David Cotán, Tamara Y Forbes-Hernandez, Alfonso Varela-López, Antonio Pérez-Pulido, Francesca Giampieri, José L Quiles, Maurizio Battino, José A Sánchez-Alcázar, Mario D Cordero
BACKGROUND: Cathepsin C (CatC) is a lysosomal enzyme involved in the activation of serine proteases from immune and inflammatory cells. Several mutations with loss of function in the Cathepsin C (CatC) gene have been shown to be the genetic mark of Papillon-Lefèvre syndrome (PLS), a rare autosomal recessive disease characterized by severe early-onset periodontitis, palmoplantar hyperkeratosis and increased susceptibility to infections. Deficiencies or dysfunction in other cathepsin family proteins such as B or D have been associated with autophagic and lysosomal disorders...
February 1, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29365444/diagnostic-value-of-circulating-mirnas-association-with-the-presence-and-extension-of-coronary-atherosclerosis-in-patients-with-suspected-ischemic-heart-disease
#8
David De Gonzalo Calvo, Jesus Sanchez Vega, David Vilades, Laura Nasarre, Ruben Leta, Francesc Carreras, Vicenta Llorente Cortes
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29337640/molecular-determinants-of-response-to-anti-programmed-cell-death-pd-1-and-anti-programmed-death-ligand-pd-l-ligand-1-blockade-in-patients-with-non-small-cell-lung-cancer-profiled-with-targeted-next-generation-sequencing
#9
Hira Rizvi, Francisco Sanchez-Vega, Konnor La, Walid Chatila, Philip Jonsson, Darragh Halpenny, Andrew Plodkowski, Niamh Long, Jennifer L Sauter, Natasha Rekhtman, Travis Hollmann, Kurt A Schalper, Justin F Gainor, Ronglai Shen, Ai Ni, Kathryn C Arbour, Taha Merghoub, Jedd Wolchok, Alexandra Snyder, Jamie E Chaft, Mark G Kris, Charles M Rudin, Nicholas D Socci, Michael F Berger, Barry S Taylor, Ahmet Zehir, David B Solit, Maria E Arcila, Marc Ladanyi, Gregory J Riely, Nikolaus Schultz, Matthew D Hellmann
Purpose Treatment of advanced non-small-cell lung cancer with immune checkpoint inhibitors (ICIs) is characterized by durable responses and improved survival in a subset of patients. Clinically available tools to optimize use of ICIs and understand the molecular determinants of response are needed. Targeted next-generation sequencing (NGS) is increasingly routine, but its role in identifying predictors of response to ICIs is not known. Methods Detailed clinical annotation and response data were collected for patients with advanced non-small-cell lung cancer treated with anti-programmed death-1 or anti-programmed death-ligand 1 [anti-programmed cell death (PD)-1] therapy and profiled by targeted NGS (MSK-IMPACT; n = 240)...
January 16, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29316426/clinical-sequencing-defines-the-genomic-landscape-of-metastatic-colorectal-cancer
#10
Rona Yaeger, Walid K Chatila, Marla D Lipsyc, Jaclyn F Hechtman, Andrea Cercek, Francisco Sanchez-Vega, Gowtham Jayakumaran, Sumit Middha, Ahmet Zehir, Mark T A Donoghue, Daoqi You, Agnes Viale, Nancy Kemeny, Neil H Segal, Zsofia K Stadler, Anna M Varghese, Ritika Kundra, Jianjiong Gao, Aijazuddin Syed, David M Hyman, Efsevia Vakiani, Neal Rosen, Barry S Taylor, Marc Ladanyi, Michael F Berger, David B Solit, Jinru Shia, Leonard Saltz, Nikolaus Schultz
Metastatic colorectal cancers (mCRCs) are clinically heterogeneous, but the genomic basis of this variability remains poorly understood. We performed prospective targeted sequencing of 1,134 CRCs. We identified splice alterations in intronic regions of APC and large in-frame deletions in CTNNB1, increasing oncogenic WNT pathway alterations to 96% of CRCs. Right-sided primary site in microsatellite stable mCRC was associated with shorter survival, older age at diagnosis, increased mutations, and enrichment of oncogenic alterations in KRAS, BRAF, PIK3CA, AKT1, RNF43, and SMAD4 compared with left-sided primaries...
January 8, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29305300/-epidemiological-characteristics-of-st-segment-elevation-myocardial-infarction-in-peru-results-of-the-peruvian-registry-of-st-segment-elevation-myocardial-infarction-perstemi
#11
Manuel Chacón-Diaz, Alejandro Vega, Ofelia Aráoz, Patricia Ríos, Roberto Baltodano, Fernando Villanueva, Alexander Montesinos, Jorge Martos, John Zevallos, David Miranda, Jorge Gutierrez, José Carasas, Alex Pecho, Sandra Negrón, Henry Anchante, Nassip Llerena, German Yabar, Javier Chumbe, Sara Ramírez, Marco Lazo, Jorge Sotomayor, Marco López, Carlos Perez
OBJECTIVE: To determine the epidemiological characteristics, treatment, reperfusion strategies and in-hospital adverse events of patients with ST elevation myocardial infarction in Peru. METHODS: Observational, prospective multicentre study in patients over 18 years admitted to hospital with a diagnosis of ST elevation myocardial infarction. RESULTS: A total of 396 patients were enrolled in the registry during February 2016 to February 2017...
January 2, 2018: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/29286843/where-does-the-transplanted-fat-is-located-in-the-gluteal-region-research-letter
#12
Guillermo Ramos-Gallardo, Pablo Medina-Zamora, Lázaro Cardenas-Camarena, David Orozco-Rentería, Héctor Duran-Vega, Eduardo Mota-Fonseca
INTRODUCTION: Liposuction is one of the most popular plastic surgery procedures. As in any surgery, there are risks and complications, especially when combined with fat injection. Case reports of fat embolism have been reported. A possible explanation is the puncture and tearing of gluteal vessels during the procedure, especially when a deep injection is planned. OBJECTIVE: To identify the places where fat can be located after injection during a fat graft in the gluteus...
December 29, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29274104/designing-connected-marine-reserves-in-the-face-of-global-warming
#13
Jorge G Álvarez-Romero, Adrián Munguía-Vega, Maria Beger, Maria Del Mar Mancha-Cisneros, Alvin N Suárez-Castillo, Georgina G Gurney, Robert L Pressey, Leah R Gerber, Hem Nalini Morzaria-Luna, Héctor Reyes-Bonilla, Vanessa M Adams, Melanie Kolb, Erin M Graham, Jeremy VanDerWal, Alejandro Castillo-López, Gustavo Hinojosa-Arango, David Petatán-Ramírez, Marcia Moreno-Baez, Carlos R Godínez-Reyes, Jorge Torre
Marine reserves are widely used to protect species important for conservation and fisheries and to help maintain ecological processes that sustain their populations, including recruitment and dispersal. Achieving these goals requires well-connected networks of marine reserves that maximize larval connectivity, thus allowing exchanges between populations and recolonization after local disturbances. However, global warming can disrupt connectivity by shortening potential dispersal pathways through changes in larval physiology...
December 22, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29258795/esophageal-symptoms-and-their-lack-of-association-with-high-resolution-manometry-in-systemic-sclerosis-patients
#14
Ana Cecilia Arana-Guajardo, Gustavo Barrera-Torres, Miguel Ángel Villarreal-Alarcón, David Vega-Morales, Jorge Antonio Esquivel-Valerio
BACKGROUND: The esophageal involvement in systemic sclerosis (SSc) causes impact in the morbidity and mortality. High resolution manometry assesses esophageal involvement. Our aim was to categorize esophageal motor disorder in patients with SSc by HRM. METHODS: We carried out an observational, descriptive and cross-sectional study. All patients underwent HRM as well as semi-structured interviews to assess frequency and severity of upper GI symptoms. Patients also completed the gastroesophageal reflux questionnaire (Carlsson-Dent)...
December 16, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29247524/rationale-and-design-of-the-long-term-risk-clinical-management-and-healthcare-resource-utilization-of-stable-coronary-artery-disease-in-post-myocardial-infarction-patients-tigris-study
#15
Dirk Westermann, Shaun G Goodman, José C Nicolau, Gema Requena, Andrew Maguire, Ji Yan Chen, Christopher B Granger, Richard Grieve, Stuart J Pocock, Stefan Blankenberg, Ana Maria Vega, Satoshi Yasuda, Tabassome Simon, David Brieger
The long-term progression of coronary artery disease as defined by the natural disease course years after a myocardial infarction (MI) is an important but poorly studied area of clinical research. The long-Term rIsk, clinical manaGement, and healthcare Resource utilization of stable coronary artery dISease in post-myocardial infarction patients (TIGRIS) study was designed to address this knowledge gap by evaluating patient management and clinical outcomes following MI in different regions worldwide. TIGRIS (ClinicalTrials...
December 16, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29240520/draft-whole-genome-sequence-analyses-on-pseudomonas-syringae-pv-actinidiae-hr-negative-strains-detected-from-kiwifruit-bleeding-sap-samples
#16
Enrico Biondi, Alan Zamorano, Ernesto Vega, Stefano Ardizzi, Davide Sitta, Roberto De Salvador, Reinaldo Campos-Vargas, Claudio Meneses, Set Pérez, Assunta Bertaccini, Nicola Fiore
Kiwifruit bleeding sap samples, collected in Italian and Chilean orchards from symptomatic and asymptomatic plants, were evaluated for the presence of Pseudomonas syringae pv. actinidiae, the causal agent of bacterial canker. The saps were sampled during the spring of both hemispheres, before the bud sprouting, during the optimal time window for the collection of an adequate volume of sample for the early detection of the pathogen, preliminarily by molecular assays, and then, through its direct isolation and identification...
December 14, 2017: Phytopathology
https://www.readbyqxmd.com/read/29237794/recommendations-of-the-global-multiple-system-atrophy-research-roadmap-meeting
#17
REVIEW
Ryan R Walsh, Florian Krismer, Wendy R Galpern, Gregor K Wenning, Phillip A Low, Glenda Halliday, Walter J Koroshetz, Janice Holton, Niall P Quinn, Olivier Rascol, Leslie M Shaw, David Eidelberg, Pam Bower, Jeffrey L Cummings, Victor Abler, Judy Biedenharn, Gal Bitan, David J Brooks, Patrik Brundin, Hubert Fernandez, Philip Fortier, Roy Freeman, Thomas Gasser, Art Hewitt, Günter U Höglinger, Matt J Huentelman, Poul H Jensen, Andreas Jeromin, Un Jung Kang, Horacio Kaufmann, Lawrence Kellerman, Vikram Khurana, Thomas Klockgether, Woojin Scott Kim, Carol Langer, Peter LeWitt, Eliezer Masliah, Wassilios Meissner, Ronald Melki, Susanne Ostrowitzki, Steven Piantadosi, Werner Poewe, David Robertson, Cyndi Roemer, Dale Schenk, Michael Schlossmacher, Jeremy D Schmahmann, Klaus Seppi, Lily Shih, Andrew Siderowf, Glenn T Stebbins, Nadia Stefanova, Shoji Tsuji, Sharon Sutton, Jing Zhang
Multiple system atrophy (MSA) is a rare neurodegenerative disorder with substantial knowledge gaps despite recent gains in basic and clinical research. In order to make further advances, concerted international collaboration is vital. In 2014, an international meeting involving leaders in the field and MSA advocacy groups was convened in Las Vegas, Nevada, to identify critical research areas where consensus and progress was needed to improve understanding, diagnosis, and treatment of the disease. Eight topic areas were defined: pathogenesis, preclinical modeling, target identification, endophenotyping, clinical measures, imaging biomarkers, nonimaging biomarkers, treatments/trial designs, and patient advocacy...
January 9, 2018: Neurology
https://www.readbyqxmd.com/read/29220675/exome-wide-association-study-identifies-greb1l-mutations-in-congenital-kidney-malformations
#18
Simone Sanna-Cherchi, Kamal Khan, Rik Westland, Priya Krithivasan, Lorraine Fievet, Hila Milo Rasouly, Iuliana Ionita-Laza, Valentina P Capone, David A Fasel, Krzysztof Kiryluk, Sitharthan Kamalakaran, Monica Bodria, Edgar A Otto, Matthew G Sampson, Christopher E Gillies, Virginia Vega-Warner, Katarina Vukojevic, Igor Pediaditakis, Gabriel S Makar, Adele Mitrotti, Miguel Verbitsky, Jeremiah Martino, Qingxue Liu, Young-Ji Na, Vinicio Goj, Gianluigi Ardissino, Maddalena Gigante, Loreto Gesualdo, Magdalena Janezcko, Marcin Zaniew, Cathy Lee Mendelsohn, Shirlee Shril, Friedhelm Hildebrandt, Joanna A E van Wijk, Adela Arapovic, Marijan Saraga, Landino Allegri, Claudia Izzi, Francesco Scolari, Velibor Tasic, Gian Marco Ghiggeri, Anna Latos-Bielenska, Anna Materna-Kiryluk, Shrikant Mane, David B Goldstein, Richard P Lifton, Nicholas Katsanis, Erica E Davis, Ali G Gharavi
No abstract text is available yet for this article.
December 7, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29212607/when-syntax-meets-action-brain-potential-evidence-of-overlapping-between-language-and-motor-sequencing
#19
Pilar Casado, Manuel Martín-Loeches, Inmaculada León, David Hernández-Gutiérrez, Javier Espuny, Francisco Muñoz, Laura Jiménez-Ortega, Sabela Fondevila, Manuel de Vega
This study aims to extend the embodied cognition approach to syntactic processing. The hypothesis is that the brain resources to plan and perform motor sequences are also involved in syntactic processing. To test this hypothesis, Event-Related brain Potentials (ERPs) were recorded while participants read sentences with embedded relative clauses, judging for their acceptability (half of the sentences contained a subject-verb morphosyntactic disagreement). The sentences, previously divided into three segments, were self-administered segment-by-segment in two different sequential manners: linear or non-linear...
November 15, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29198929/racial-differences-in-the-development-of-de-novo-donor-specific-antibodies-and-treated-antibody-mediated-rejection-after-heart-transplantation
#20
Robert Townsend Cole, Jonathan Gandhi, Robert A Bray, Howard M Gebel, Michael Yin, Nikolaz Shekiladze, An Young, Aubrey Grant, Ian Mahoney, S Raja Laskar, Divya Gupta, Kunal Bhatt, Wendy Book, Andrew Smith, Duc Nguyen, J David Vega, Alanna A Morris
BACKGROUND: Despite improvements in outcomes after heart transplantation, black recipients have worse survival compared with non-black recipients. The source of such disparate outcomes remains largely unknown. We hypothesize that a propensity to generate de-novo donor-specific antibodies (dnDSA) and subsequent antibody-mediated rejection (AMR) may account for racial differences in sub-optimal outcomes after heart transplant. In this study we aimed to determine the role of dnDSA and AMR in racial disparities in post-transplant outcomes...
November 4, 2017: Journal of Heart and Lung Transplantation
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