keyword
MENU ▼
Read by QxMD icon Read
search

E Sarin

keyword
https://www.readbyqxmd.com/read/29460445/microvesicles-in-hepatic-and-peripheral-vein-can-predict-nonresponse-to-corticosteroid-therapy-in-severe-alcoholic-hepatitis
#1
S Sukriti, J S Maras, C Bihari, S Das, A K Vyas, S Sharma, S Hussain, S Shasthry, A Choudhary, M Premkumar, D Kumar, G Kumar, C Mukhopadhyay, A Kumar, N Trehanpati, P E Rautou, R Moreau, S K Sarin
BACKGROUND: Severe alcoholic hepatitis patients have high mortality and limited response to corticosteroids. Microvesicles reflect cellular stress and disease conditions. AIMS: To investigate whether microvesicles are associated with severity, response to steroid therapy and inflammation in severe alcoholic hepatitis. METHODS: Microvesicles originating from different cells were studied pre-therapy in 101 patients; (71 responder to corticosteroid therapy and 30 nonresponders) and 20 healthy controls...
February 20, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29432916/e-cigarette-advertising-exposure-in-e-cigarette-na%C3%A3-ve-adolescents-and-subsequent-e-cigarette-use-a-longitudinal-cohort-study
#2
Deepa Camenga, Kevin M Gutierrez, Grace Kong, Dana Cavallo, Patricia Simon, Suchitra Krishnan-Sarin
OBJECTIVE: Electronic (E-) cigarettes are one of the most popular tobacco products used by adolescents today. This study examined whether exposure to advertisements in (1) social networking sites (Facebook, Twitter, YouTube, Pinterest/Google Plus), (2) traditional media (television/radio, magazines, billboards), or (3) retail stores (convenience stores, mall kiosks, tobacco shops) was associated with subsequent e-cigarette use in a longitudinal cohort of adolescents. METHODS: Data were drawn from longitudinal surveys conducted in fall 2013 (wave 1) and spring 2014 (wave 2) of a school-based cohort attending 3 high schools and 2 middle schools in Connecticut...
February 6, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29411963/metal-organic-framework-modified-glass-substrate-for-analysis-of-highly-volatile-chemical-warfare-agents-by-paper-spray-mass-spectrometry
#3
Elizabeth S Dhummakupt, Daniel Carmany, Phillip M Mach, Trenton M Tovar, Ann M Ploskonka, Paul S Demond, Jared B DeCoste, Trevor Glaros
Paper spray mass spectrometry (PS-MS) has been shown to successfully analyze chemical warfare agent (CWA) simulants. However, due to the volatility differences between the simulants and real G-series (i.e. sarin, soman) CWAs, analysis from an untreated paper substrate proved difficult. In order to extend the analytical lifetime of these G-agents, metal-organic frameworks (MOFs) were successfully integrated onto the paper spray substratesto increase adsorption and desorption. In this study, several MOFs and nanoparticles were tested to extend the analytical lifetime of sarin, soman, and cyclosarin on paper spray substrates...
February 7, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29400712/noncanonical-hedgehog-pathway-activation-through-srf-mkl1-promotes-drug-resistance-in-basal-cell-carcinomas
#4
Ramon J Whitson, Alex Lee, Nicole M Urman, Amar Mirza, Catherine Y Yao, Alexander S Brown, Jiang R Li, Gautam Shankar, Micah A Fry, Scott X Atwood, Eunice Y Lee, S Tyler Hollmig, Sumaira Z Aasi, Kavita Y Sarin, Matthew P Scott, Ervin H Epstein, Jean Y Tang, Anthony E Oro
Hedgehog pathway-dependent cancers can escape Smoothened (SMO) inhibition through mutations in genes encoding canonical hedgehog pathway components; however, around 50% of drug-resistant basal cell carcinomas (BCCs) lack additional variants of these genes. Here we use multidimensional genomics analysis of human and mouse drug-resistant BCCs to identify a noncanonical hedgehog activation pathway driven by the transcription factor serum response factor (SRF). Active SRF along with its coactivator megakaryoblastic leukemia 1 (MKL1) binds DNA near hedgehog target genes and forms a previously unknown protein complex with the hedgehog transcription factor glioma-associated oncogene family zinc finger-1 (GLI1), causing amplification of GLI1 transcriptional activity...
February 5, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29367863/fatal-sarin-poisoning-in-syria-2013-forensic-verification-within-an-international-laboratory-network
#5
Harald John, Marcel J van der Schans, Marianne Koller, Helma E T Spruit, Franz Worek, Horst Thiermann, Daan Noort
During the United Nations fact-finding mission to investigate the alleged use of chemical warfare agents in the Syrian Arab Republic in 2013, numerous tissues from a deceased female victim, who had displayed symptoms of cholinergic crisis, were collected. The Organisation for the Prohibition of Chemical Weapons (OPCW) authorized two specialized laboratories in the Netherlands and Germany for forensic analysis of these samples. Diverse modern mass spectrometry (MS)-based procedures in combination with either liquid chromatography (LC) or gas chromatography (GC) separation were applied...
2018: Forensic Toxicology
https://www.readbyqxmd.com/read/29352698/gastric-varices-bleed-at-lower-portosystemic-pressure-gradients-than-esophageal-varices
#6
Joseph D Morrison, Nasya Mendoza-Elias, Andrew J Lipnik, R Peter Lokken, James T Bui, Charles E Ray, Ron C Gaba
PURPOSE: To quantify and compare portosystemic pressure gradients (PSGs) between bleeding esophageal varices (EV) and gastric varices (GV). MATERIALS AND METHODS: In a single-center, retrospective study, 149 patients with variceal bleeding (90 men, 59 women, mean age 52 y) with EV (n = 69; 46%) or GV (n = 80; 54%) were selected from 320 consecutive patients who underwent successful transjugular intrahepatic portosystemic shunt (TIPS) creation from 1998 to 2016...
January 15, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29350618/a-call-to-end-the-epidemic-of-adolescent-e-cigarette-use
#7
Grace Kong, Suchitra Krishnan-Sarin
No abstract text is available yet for this article.
May 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29324591/visualization-from-intraoperative-swept-source-microscope-integrated-optical-coherence-tomography-in-vitrectomy-for-complications-of-proliferative-diabetic-retinopathy
#8
Hesham Gabr, Xi Chen, Oscar M Zevallos-Carrasco, Christian Viehland, Alexandria Dandrige, Neeru Sarin, Tamer H Mahmoud, Lejla Vajzovic, Joseph A Izatt, Cynthia A Toth
PURPOSE: To evaluate the use of live volumetric (4D) intraoperative swept-source microscope-integrated optical coherence tomography in vitrectomy for proliferative diabetic retinopathy complications. METHODS: In this prospective study, we analyzed a subgroup of patients with proliferative diabetic retinopathy complications who required vitrectomy and who were imaged by the research swept-source microscope-integrated optical coherence tomography system. In near real time, images were displayed in stereo heads-up display facilitating intraoperative surgeon feedback...
January 10, 2018: Retina
https://www.readbyqxmd.com/read/29304425/age-at-drinking-onset-age-at-first-intoxication-and-delay-to-first-intoxication-assessing-the-concurrent-validity-of-measures-of-drinking-initiation-with-alcohol-use-and-related-problems
#9
Meghan E Morean, Alexa L'Insalata, Ellyn R Butler, Avalon McKee, Suchitra Krishnan-Sarin
INTRODUCTION: Drinking at an early age (AO) and quickly progressing to drinking to intoxication (Delay=Age of Intoxication[AI]-AO) confer risk for alcohol use and alcohol-related problems. However, inconsistencies exist in the literature, which may reflect the use of different definitions of AO and AI. We evaluated whether 1) defining AO as age at first sip of alcohol (AO sip) versus age at which at least one standard drink was consumed (AO drink); and 2) defining AI as age at first "drunk" (AI drunk) versus age at first binge episode (≥5 standard drinks consumed; AI binge) resulted in different self-reported ages or differentially predicted drinking outcomes...
December 21, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29301008/psychometric-evaluation-of-the-patient-reported-outcomes-measurement-information-system-promis-nicotine-dependence-item-bank-for-use-with-electronic-cigarettes
#10
Meghan Morean, Suchitra Krishnan-Sarin, Steve Sussman, Jonathan Foulds, Howard Fishbein, Rachel Grana, Stephanie S O'Malley
Introduction: Psychometrically sound measures of e-cigarette dependence are lacking. Methods: We modified the PROMIS Nicotine Dependence Item Banks for use with e-cigarettes and evaluated the psychometrics of the 22-, 8- and 4-item adapted versions. 1009 adults who reported using e-cigarettes at least weekly completed an anonymous survey in Summer 2016 (50.2% male, 77.1% White, mean age 35.81 [10.71], 66.4% daily e-cigarette users, 72.6% current cigarette smokers)...
January 2, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29300749/preferring-more-e-cigarette-flavors-is-associated-with-e-cigarette-use-frequency-among-adolescents-but-not-adults
#11
Meghan E Morean, Ellyn R Butler, Krysten W Bold, Grace Kong, Deepa R Camenga, Dana A Cavallo, Patricia Simon, Stephanie S O'Malley, Suchitra Krishnan-Sarin
INTRODUCTION: Many e-cigarette users find the variety of e-cigarette flavors appealing. We examined whether preferences for e-liquid flavors and the total number of flavors preferred differed between samples of adolescent and adult e-cigarette users. We also examined whether these preferences were associated with e-cigarette use frequency for adolescents or adults, respectively. MATERIALS AND METHODS: The analytic samples comprised 1) 396 adolescent, past-month e-cigarette users from 5 Connecticut high schools who completed an anonymous, school-based survey in Fall 2014 (56...
2018: PloS One
https://www.readbyqxmd.com/read/29246953/ca2-dependent-regulation-of-nfatc1-via-kca3-1-in-inflammatory-osteoclastogenesis
#12
Eva M Grössinger, Mincheol Kang, Laura Bouchareychas, Ritu Sarin, Dominik R Haudenschild, Laura N Borodinsky, Iannis E Adamopoulos
In inflammatory arthritis, the dysregulation of osteoclast activity by proinflammatory cytokines, including TNF, interferes with bone remodeling during inflammation through Ca2+-dependent mechanisms causing pathological bone loss. Ca2+-dependent CREB/c-fos activation via Ca2+-calmodulin kinase IV (CaMKIV) induces transcriptional regulation of osteoclast-specific genes via NFATc1, which facilitate bone resorption. In leukocytes, Ca2+ regulation of NFAT-dependent gene expression oftentimes involves the activity of the Ca2+-activated K+ channel KCa3...
December 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29210278/decellularized-liver-matrix-modified-cryogel-scaffolds-as-potential-hepatocyte-carriers-in-bioartificial-liver-support-systems-and-implantable-liver-constructs
#13
Apeksha Damania, Anupam Kumar, Arun Kumar Teotia, Kimura Haruna, Masamichi Kamihira, Hiroyuki Ijima, Shiv Kumar Sarin, Ashok Kumar
Recent progress in the use of decellularized organ scaffolds as regenerative matrices for tissue engineering holds great promise in addressing the issue of donor organ shortage. Decellularization preserves the mechanical integrity, composition, and microvasculature critical for zonation of hepatocytes in the liver. Earlier studies have reported the possibility of repopulating decellularized matrices with hepatic cell lines or stem cells to improve liver regeneration. In this work, we study the versatility of decellularized liver matrix as a substrate coating of 3D cryogel scaffolds...
December 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29203523/trajectories-of-e-cigarette-and-conventional-cigarette-use-among-youth
#14
Krysten W Bold, Grace Kong, Deepa R Camenga, Patricia Simon, Dana A Cavallo, Meghan E Morean, Suchitra Krishnan-Sarin
BACKGROUND: Electronic cigarette (e-cigarette) use is common among youth, and there are concerns that e-cigarette use leads to future conventional cigarette use. We examined longitudinal associations between past-month cigarette and e-cigarette use to characterize the stability and directionality of these tobacco use trajectories over time. METHODS: High school students (N = 808, 53% female) completed surveys across 3 waves (2013, 2014, and 2015) in 3 public schools in Connecticut...
January 2018: Pediatrics
https://www.readbyqxmd.com/read/29174664/measuring-e-cigarette-dependence-initial-guidance
#15
Krysten W Bold, Steve Sussman, Stephanie S O'Malley, Rachel Grana, Jonathan Foulds, Howard Fishbein, Suchitra Krishnan-Sarin
E-cigarette use rates are increasing among youth and adults, despite limited knowledge about the safety, risks, and potential for this product in substituting for or reducing other tobacco use. Understanding how to characterize and assess e-cigarette dependence will be important for evaluating the public health impact of e-cigarettes and considering prevention and intervention strategies. To provide an initial review of constructs to consider when assessing e-cigarette dependence, a content expert group within the Tobacco Center for Regulatory Science (TCORS) Measurement Workgroup engaged in a review of published manuscripts and 12 tobacco dependence measures, followed by review of suggested dependence domains by a 10-person external subject-matter expert panel...
November 22, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29159359/highly-selective-and-sensitive-chromogenic-detection-of-nerve-agents-sarin-tabun-and-vx-a-multianalyte-detection-approach
#16
Vinod Kumar, G Raviraju, Hemlata Rana, Vepa Kameswara Rao, Arvind K Gupta
A novel strategy using ferrocenyl dye (1) was developed for highly selective chromogenic detection of all nerve agents. The protocol was first established with nerve agent mimics (DFP, DCNP, and malaoxon) and then implemented on real agents, i.e. sarin, tabun and VX. The developed chemosensor showed no interferences from the most probable interferents such as acetyl chloride, sulfur mustard, oxygen mustard and DMMP. Real-time visual detection with a lower limit of detection (below LD50) made the present protocol highly appealing and versatile...
November 21, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29155110/delayed-traumatic-aortic-pseudoaneurysm-formation-causing-vertebral-body-erosion-and-back-pain-case-report-and-literature-review
#17
Justin M Cappuzzo, Kathleen E Knudson, Shawn Sarin, Joseph Babrowicz, Abraham Cherrick, Jonathan H Sherman
BACKGROUND: Aortic pseudoaneurysms are a rare cause of chronic back pain, usually due to compression of adjacent neurovasculature. It is uncommon for patients with pseudoaneurysms of the abdominal aorta to present in a delayed fashion after initial traumatic injury. CASE DESCRIPTION: We present an unusual case of delayed pseudoaneurysm formation, with subsequent erosion into the adjacent L1 vertebral body. This pseudoaneurysm was secondary to a gunshot wound with retained ballistic fragment that occurred 27 years prior...
November 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29151838/observation-and-model-based-estimates-of-particulate-dry-nitrogen-deposition-to-the-oceans
#18
Alex R Baker, Maria Kanakidou, Katye E Altieri, Nikos Daskalakis, Gregory S Okin, Stelios Myriokefalitakis, Frank Dentener, Mitsuo Uematsu, Manmohan M Sarin, Robert A Duce, James N Galloway, William C Keene, Arvind Singh, Lauren Zamora, Jean-Francois Lamarque, Shih-Chieh Hsu, Shital S Rohekar, Joseph M Prospero
Anthropogenic nitrogen (N) emissions to the atmosphere have increased significantly the deposition of nitrate (NO3(-)) and ammonium (NH4(+)) to the surface waters of the open ocean, with potential impacts on marine productivity and the global carbon cycle. Global-scale understanding of the impacts of N deposition to the oceans is reliant on our ability to produce and validate models of nitrogen emission, atmospheric chemistry, transport and deposition. In this work, ~2900 observations of aerosol NO3(-) and NH4(+) concentrations, acquired from sampling aboard ships in the period 1995 - 2012, are used to assess the performance of modelled N concentration and deposition fields over the remote ocean...
2017: Atmospheric Chemistry and Physics
https://www.readbyqxmd.com/read/29129799/post-exposure-treatment-with-the-oxime-rs194b-rapidly-reactivates-and-reverses-advanced-symptoms-of-lethal-inhaled-paraoxon-in-macaques
#19
Yvonne J Rosenberg, Jerry Wang, Tara Ooms, Narayanan Rajendran, Lingjun Mao, Xiaoming Jiang, Jonathan Lees, Lori Urban, Jeremiah Romper, Yadire Sepulveda, Yan-Jye Shyong, Palmer Taylor
Fatalities from organophosphate (OP) insecticide result from both occupational and deliberate exposure; significantly impacting human health. Like nerve agents, insecticides are neurotoxins which target and inhibit acetylcholinesterases (AChE) in central and peripheral synapses in the cholinergic nervous system. Post-exposure therapeutic countermeasures generally include administration of atropine with a pyridinium aldoximes e.g. pralidoxime, to reactivate the OP-inhibited AChE. However, commonly used oximes inefficiently cross the blood brain barrier and are rapidly cleared and their benefit is debated...
November 9, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29093271/combined-inhibition-of-atypical-pkc-and-histone-deacetylase-1-is-cooperative-in-basal-cell-carcinoma-treatment
#20
Amar N Mirza, Micah A Fry, Nicole M Urman, Scott X Atwood, Jon Roffey, Gregory R Ott, Bin Chen, Alex Lee, Alexander S Brown, Sumaira Z Aasi, Tyler Hollmig, Mark A Ator, Bruce D Dorsey, Bruce R Ruggeri, Craig A Zificsak, Marina Sirota, Jean Y Tang, Atul Butte, Ervin Epstein, Kavita Y Sarin, Anthony E Oro
Advanced basal cell carcinomas (BCCs) circumvent Smoothened (SMO) inhibition by activating GLI transcription factors to sustain the high levels of Hedgehog (HH) signaling required for their survival. Unfortunately, there is a lack of efficacious therapies. We performed a gene expression-based drug repositioning screen in silico and identified the FDA-approved histone deacetylase (HDAC) inhibitor, vorinostat, as a top therapeutic candidate. We show that vorinostat only inhibits proliferation of BCC cells in vitro and BCC allografts in vivo at high dose, limiting its usefulness as a monotherapy...
November 2, 2017: JCI Insight
keyword
keyword
59194
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"