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https://www.readbyqxmd.com/read/28728785/operative-strategies-to-reduce-cerebral-embolic-events-during-on-and-off-pump-coronary-artery-bypass-surgery-a-stratified-prospective-randomized-trial
#1
Michael E Halkos, Aaron Anderson, Jose Nilo G Binongo, Anthony Stringer, Yi Lasanajak, Vinod H Thourani, Omar M Lattouf, Robert A Guyton, Kim T Baio, Eric Sarin, William B Keeling, N Renee Cook, Katherine Carssow, Alexis Neill, Kathryn E Glas, John D Puskas
OBJECTIVE: To determine the impact of different aortic clamping strategies on the incidence of cerebral embolic events during coronary artery bypass grafting (CABG). METHODS: Between 2012 and 2015, 142 patients with low-grade aortic disease (epiaortic ultrasound grade I/II) undergoing primary isolated CABG were studied. Those undergoing off-pump CABG were randomized to a partial clamp (n = 36) or clampless facilitating device (CFD; n = 36) strategy. Those undergoing on-pump CABG were randomized to a single-clamp (n = 34) or double-clamp (n = 36) strategy...
June 16, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28678576/reliability-of-18-f-fdg-pet-metabolic-parameters-derived-using-simultaneous-pet-mri-and-correlation-with-prognostic-factors-of-invasive-ductal-carcinoma-a-feasibility-study
#2
Amarnath Jena, Sangeeta Taneja, Aru Singh, Pradeep Negi, Ramesh Sarin, Pratap K Das, Manish Singhal
OBJECTIVE: The objective of our study was to correlate semiquantitative PET parameters-standardized uptake value (SUV) and total lesion glycolysis (TLG)-derived in simultaneous PET/MRI using MRI-based attenuation correction with clinical and histopathologic prognostic factors in patients with breast cancer. MATERIALS AND METHODS: Eighty-two invasive ductal carcinomas in 69 women were included in the study. All the subjects underwent whole-body (WB) PET/MRI (supine WB mode) and dedicated PET/MRI of the breast (prone breast imaging mode) for staging on a simultaneous PET/MRI system...
July 5, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28673485/high-resolution-crystal-structure-of-a-fluoride-inhibited-organophosphate-degrading-metallohydrolase
#3
Christopher Selleck, Luke W Guddat, David L Ollis, Gerhard Schenk, Marcelo Monteiro Pedroso
Metal ion-dependent, organophosphate-degrading enzymes (OP hydrolases) have received increasing attention due to their ability to degrade and thus detoxify commonly used pesticides and nerve agents such as sarin and VX. These enzymes thus garner strong potential as bioremediators. The OP hydrolase from Agrobacterium radiobacter (OpdA) is one of the most efficient members of this group of enzymes. Previous studies have indicated that the choice of the hydrolysis-initiating nucleophile may depend on the pH of the reaction, with a metal ion-bridging hydroxide being preferred at lower pH (i...
June 27, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28634886/subcortical-brain-atrophy-in-gulf-war-illness
#4
Peka Christova, Lisa M James, Brian E Engdahl, Scott M Lewis, Adam F Carpenter, Apostolos P Georgopoulos
Gulf War Illness (GWI) is a multisystem disorder that has affected a substantial number of veterans who served in the 1990-1991 Gulf War. The brain is prominently affected, as manifested by the presence of neurological, cognitive and mood symptoms. Although brain dysfunction in GWI has been well documented (EBioMedicine 12:127-32, 2016), abnormalities in brain structure have been debated. Here we report a substantial (~10%) subcortical brain atrophy in GWI comprising mainly the brainstem, cerebellum and thalamus, and, to a lesser extent, basal ganglia, amygdala and diencephalon...
June 20, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28631147/the-motor-cortical-representation-of-a-muscle-is-not-homogeneous-in-brain-connectivity
#5
Jo Armour Smith, Alaa Albishi, Sarine Babikian, Skulpan Asavasopon, Beth E Fisher, Jason J Kutch
Functional connectivity patterns of the motor cortical representational area of single muscles have not been extensively mapped in humans, particularly for the axial musculature. Functional connectivity may provide a neural substrate for adaptation of muscle activity in axial muscles that have both voluntary and postural functions. The purpose of this study was to combine brain stimulation and neuroimaging to both map the cortical representation of the external oblique (EO) in primary motor cortex (M1) and supplementary motor area (SMA), and to establish the resting-state functional connectivity associated with this representation...
June 19, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28500636/immune-correlates-of-hepatitis-b-surface-antigen-spontaneous-seroconversion-in-hepatitis-b-e-antigen-negative-chronic-hepatitis-b-patients
#6
Ashish Kumar Vyas, Barjesh Chander Sharma, Shiv Kumar Sarin, Nirupma Trehanpati
BACKGROUND: Hepatitis B surface antigen (HBsAg) seroconversion in HBeAg-ve chronic hepatitis B (CHB) infection is rare, possibly due to poor antigen processing and impaired humoral response. We investigated the role of dendritic cells (DCs), T follicular helper (TFH) cells and plasma B cells in seroconversion. METHODS: HBeAg-ve (n=135) CHB patients with raised ALT at baseline were followed-up. Patients undergoing HBsAg sero-conversion (Gr. I, n=11) were compared with non-converters with low (Gr...
May 13, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28460123/use-of-electronic-cigarettes-leads-to-significant-beta2-nicotinic-acetylcholine-receptor-occupancy-evidence-from-a-pet-imaging-study
#7
Stephen R Baldassarri, Ansel T Hillmer, Jon Mikael Anderson, Peter Jatlow, Nabeel Nabulsi, David Labaree, Kelly P Cosgrove, Stephanie S O'Malley, Thomas Eissenberg, Suchitra Krishnan-Sarin, Irina Esterlis
Background: Electronic cigarettes (ECs) can influence nicotine addiction by delivering aerosolized nicotine. We investigated if nicotine from ECs is delivered to the brain β2*-nicotinic-acetylcholine receptors (β2*-nAChR) and how this relates to the behavioral effects and nicotine delivery from cigarettes. Methods: Seven nicotine users participated in positron emission tomography (PET) studies with (-)-[18F]Flubatine before and after nicotine challenge with 0, 8 mg/ml, and 36 mg/ml nicotine in a 3...
April 29, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28413835/mirna-signatures-can-predict-acute-liver-failure-in-hepatitis-e-infected-pregnant-females
#8
Nirupma Trehanpati, Rashi Sehgal, Sharda Patra, Ashish Vyas, Madavan Vasudevan, Ritu Khosla, Arshi Khanam, Guresh Kumar, Rakhi Maiwall, Gayatri Ramakrishna, Shyam Kottilil, Shiv Kumar Sarin
BACKGROUND: Acute viral hepatitis E (AVH-E) can often result in acute liver failure (ALF) during pregnancy. microRNAs serve as mediators in drug induced liver failure. We investigated their role as a biomarker in predicting ALF due to HEV (ALF-E). METHODS: We performed next generation sequencing and subsequent validation studies in PBMCs of pregnant (P) self limiting AVH-E, ALF due to HEV (ALF-E) and compared with AVH-E in non-pregnant (NP) females and healthy controls...
April 2017: Heliyon
https://www.readbyqxmd.com/read/28392289/correlates-of-multiple-basal-cell-carcinoma-in-a-retrospective-cohort-study-sex-histologic-subtypes-and-anatomic-distribution
#9
Karen Y Kuo, Prag Batra, Hyunje G Cho, Shufeng Li, Harvind S Chahal, Kerri E Rieger, Jean Y Tang, Kavita Y Sarin
No abstract text is available yet for this article.
August 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28377414/diagnostic-distinction-of-malignant-melanoma-and-benign-nevi-by-a-gene-expression-signature-and-correlation-to-clinical-outcomes
#10
Jennifer S Ko, Balwir Matharoo-Ball, Steven D Billings, Brian J Thomson, Jean Y Tang, Kavita Y Sarin, Emily Cai, Jinah Kim, Colleen Rock, Hillary Z Kimbrell, Darl D Flake, M Bryan Warf, Jonathan Nelson, Thaylon Davis, Catherine Miller, Kristen Rushton, Anne-Renee Hartman, Richard J Wenstrup, Loren E Clarke
Background: Histopathologic examination alone can be inadequate for diagnosis of certain melanocytic neoplasms. Recently, a 23-gene expression signature was clinically validated as an ancillary diagnostic test to differentiate benign nevi from melanoma. The current study assessed the performance of this test in an independent cohort of melanocytic lesions against clinically proven outcomes.Methods: Archival tissue from primary cutaneous melanomas and melanocytic nevi was obtained from four independent institutions and tested with the gene signature...
July 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28374414/systemic-inflammatory-response-syndrome-in-acute-on-chronic-liver-failure-relevance-of-golden-window-a-prospective-study
#11
A Choudhury, M Kumar, B C Sharma, R Maiwall, V Pamecha, R Moreau, Y K Chawla, A Duseja, M Mahtab, S Rahman, S S Hamid, A S Butt, W Jafri, S S Tan, H Devarbhavi, D Amarapurkar, Q Ning, C E Eapen, Ashish Goel, D J Kim, H Ghazinian, G Shiha, G H Lee, Z Abbas, D A Payawal, A K Dokmeci, M F Yuen, L A Lesmana, Ajit Sood, A Chan, G K Lau, J I Dong Jia, Z Duan, Yu Chen, O Yokosuka, P Jain, A S Bhadoria, G Kumar, S K Sarin
BACKGROUND: SIRS is an early marker of sepsis and ongoing inflammationand has been reported in large proportion of ACLF patients. Whether sepsis is the cause or the result of liver failure is unclear and is vital to know. To address this, we investigated the course and outcome of ACLF patients without SIRS/sepsis. METHODS: Consecutive ACLF patients were monitored for the development of SIRS/sepsis and associated complications and followed till 90 days, liver transplant or death...
April 3, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28371890/type-of-e-cigarette-device-used-among-adolescents-and-young-adults-findings-from-a-pooled-analysis-of-8-studies-of-2-166-vapers
#12
Jessica L Barrington-Trimis, Laura A Gibson, Bonnie Halpern-Felsher, Melissa B Harrell, Grace Kong, Suchitra Krishnan-Sarin, Adam M Leventhal, Alexandra Loukas, Rob McConnell, Scott R Weaver
Background: A recent study of adult smokers who vape found that disposable/cigalike electronic (e-) cigarette devices were more commonly used than later generation devices. However, whether these trends reflect patterns among adolescents and young adults, many of whom have limited or no history of combustible cigarette use, has not been studied. Methods: Participants were drawn from 8 locally, regionally, and U.S. nationally representative studies. Surveys took place between Fall 2014 and Spring 2016; participants were residents of California (3 studies), Texas (2 studies), Connecticut (1 study), or randomly selected from the United States population (2 studies)...
March 22, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28347698/postzygotic-mutations-in-beta-actin-are-associated-with-becker-s-nevus-and-becker-s-nevus-syndrome
#13
Emily D Cai, Bryan K Sun, Audris Chiang, Anna Rogers, Laura Bernet, Binbin Cheng, Joyce Teng, Kerri E Rieger, Kavita Y Sarin
No abstract text is available yet for this article.
March 24, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28343564/embryos-of-non-native-anoles-are-robust-to-urban-thermal-environments
#14
Sarin Tiatragul, Audeline Kurniawan, Jason J Kolbe, Daniel A Warner
The transformation of natural habitats into urban landscapes dramatically alters thermal environments, which in turn, can impact local biota. Ectothermic organisms that are oviparous are particularly sensitive to these altered environments because their embryos cannot behaviorally thermoregulate and the surrounding environment determines the temperature experienced during development. We studied the effects of urban and forested thermal environments on embryo development and hatchling phenotypes in two non-native lizards (Anolis sagrei and A...
April 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28244455/epidemiological-and-survival-analysis-of-triple-negative-breast-cancer-cases-in-a-retrospective-multicenter-study
#15
MULTICENTER STUDY
R Sarin, L Khandrika, Rnm Hanitha, A Avula, M Batra, S Kaul, H Raj, S Shivkumar, S Gupta, E Khan, Tps Bhandari, Svss Prasad, V A Reddy, G Swarnalata, M Bakre, S Chatterjee, J Jain
INTRODUCTION: This is a retrospective study with data collected from breast cancer cases from five major Apollo Hospitals across India, as part of a biobanking process. One aspect of our study focused specifically on data from triple-negative breast cancer (TNBC) cases. The aim of this study was to analyze epidemiology, treatment options, and survival of the patients with TNBC. Our goal was to draw conclusions on the preponderance of the disease and also to understand the outcomes using the existing therapy options...
July 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28212542/two-stage-genome-wide-association-study-identifies-a-novel-susceptibility-locus-associated-with-melanoma
#16
Katherine J Ransohoff, Wenting Wu, Hyunje G Cho, Harvind C Chahal, Yuan Lin, Hong-Ji Dai, Christopher I Amos, Jeffrey E Lee, Jean Y Tang, David A Hinds, Jiali Han, Qingyi Wei, Kavita Y Sarin
Genome-wide association studies have identified 21 susceptibility loci associated with melanoma. These loci implicate genes affecting pigmentation, nevus count, telomere maintenance, and DNA repair in melanoma risk. Here, we report the results of a two-stage genome-wide association study of melanoma. The stage 1 discovery phase consisted of 4,842 self-reported melanoma cases and 286,565 controls of European ancestry from the 23andMe research cohort and the stage 2 replication phase consisted of 1,804 melanoma cases and 1,026 controls from the University of Texas M...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28167512/e-cigarettes-and-dripping-among-high-school-youth
#17
Suchitra Krishnan-Sarin, Meghan Morean, Grace Kong, Krysten W Bold, Deepa R Camenga, Dana A Cavallo, Patricia Simon, Ran Wu
BACKGROUND: Electronic cigarettes (e-cigarettes) electrically heat and vaporize e-liquids to produce inhalable vapors. These devices are being used to inhale vapors produced by dripping e-liquids directly onto heated atomizers. The current study conducts the first evaluation of the prevalence rates and reasons for using e-cigarettes for dripping among high school students. METHODS: In the spring of 2015, students from 8 Connecticut high schools (n = 7045) completed anonymous surveys that examined tobacco use behaviors and perceptions...
March 2017: Pediatrics
https://www.readbyqxmd.com/read/28161821/cortical-activity-predicts-good-variation-in-human-motor-output
#18
Sarine Babikian, Eva Kanso, Jason J Kutch
Human movement patterns have been shown to be particularly variable if many combinations of activity in different muscles all achieve the same task goal (i.e., are goal-equivalent). The nervous system appears to automatically vary its output among goal-equivalent combinations of muscle activity to minimize muscle fatigue or distribute tissue loading, but the neural mechanism of this "good" variation is unknown. Here we use a bimanual finger task, electroencephalography (EEG), and machine learning to determine if cortical signals can predict goal-equivalent variation in finger force output...
April 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28089000/incidence-ratio-of-basal-cell-carcinoma-to-squamous-cell-carcinoma-equalizes-with-age
#19
Harvind S Chahal, Kerri E Rieger, Kavita Y Sarin
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28045774/study-of-carnitine-acylcarnitine-and-amino-acid-profile-in-children-and-adults-with-acute-liver-failure
#20
Vikrant Sood, Dinesh Rawat, Rajeev Khanna, Shvetank Sharma, Prem K Gupta, Seema Alam, Shiv Kumar Sarin
OBJECTIVES: Fatty acid oxidation defects (FAODs) may underlie or modify the course of acute liver failure (ALF). Overall significance of carnitine/acylcarnitine and amino acid profile in ALF is similarly undetermined. Thus, this study was undertaken to study the abnormalities in carnitine/acylcarnitine and amino acid profile in ALF. METHODS: A prospective study was performed including all patients with ALF, and detailed evaluation including metabolic testing was done...
June 2017: Journal of Pediatric Gastroenterology and Nutrition
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