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M Sancheti

Sushil F Sancheti, Vishal Uppal, Robert Sandeski, M Kwesi Kwofie, Jennifer J Szerb
BACKGROUND AND OBJECTIVES: Retroclavicular block is designed to overcome the negative aspects of the commonly utilized ultrasound-guided parasagittal approach to the infraclavicular block. However, this approach necessitates the needle traversing an area posterior to the clavicle inaccessible to ultrasound wave conduction. This study sought to document the structures vulnerable to needle injury during a retroclavicular block. METHODS: A Tuohy needle was inserted using a retroclavicular approach to the infraclavicular block in 3 lightly embalmed cadavers followed by a catheter insertion 4 cm beyond the needle tip...
June 19, 2018: Regional Anesthesia and Pain Medicine
Abhijeet D Kulkarni, Yogesh H Vanjari, Karan H Sancheti, Harun M Patel, Veena S Belgamwar, Sanjay J Surana, Chandrakantsing V Pardeshi
Although chitosan (CHT, a linear cationic polysaccharide) is biodegradable, biocompatible, non-toxic, and mucoadhesive in nature, the low solubility of CHT in aqueous and alkaline media limits its applicability in pharmaceutical and biomedical field. This necessitate the introduction of new chemically-modified derivatives of CHT those can surmount the solubility barrier. Herein, N,N,N-trimethyl chitosan (TMC), a quaternized hydrophilic derivative of CHT, was synthesized by two-step reductive methylation of CHT and characterized for (1)H NMR and zeta potential measurements...
July 2016: International Journal of Biological Macromolecules
Abhijeet D Kulkarni, Yogesh H Vanjari, Karan H Sancheti, Harun M Patel, Veena S Belgamwar, Sanjay J Surana, Chandrakantsing V Pardeshi
The polyelectrolyte complexes (PECs) are versatile formulations formed by electrostatic interactions between oppositely charged biopolymers. PECs have been investigated widely by the researchers to explore the virtues of this formulation viz. high biocompatibility, excellent biodegradability, low toxicity, cost-effective, environment-friendly, and energy-efficient production. The prime object of the present review is to present the prominent features of PECs including mechanism of PEC formation, structural models of PECs, interactions involved in PEC formation, steps involved in PEC fabrication, factors affecting the formation of PECs and applications of PECs...
November 2016: Artificial Cells, Nanomedicine, and Biotechnology
Nikita S Jalan, Sonam S Daftari, Seemi S Retharekar, Savita A Rairikar, Ashok M Shyam, Parag K Sancheti
BACKGROUND: Measurement of maximum inspiratory pressure is the most prevalent method used in clinical practice to assess the strength of the inspiratory muscles. Although there are many devices available for the assessment of inspiratory muscle strength, there is a dearth of literature describing the reliability of devices that can be used in clinical patient assessment. The capsule-sensing pressure gauge (CSPG-V) is a new tool that measures the strength of inspiratory muscles; it is easy to use, noninvasive, inexpensive and lightweight...
2015: Canadian Journal of Respiratory Therapy: CJRT
J N Melvan, S D Force, M S Sancheti
INTRODUCTION: Rare vascular malformations are discovered infrequently in donor lungs before implantation into recipients. However, the proper handling of such malformations can influence ischemic time, implantation strategies, and subsequent patient outcomes. CASE REPORT: We report a simplified method for addressing the technical challenges of anomalous pulmonary venous return in a donor lung before implantation. CONCLUSIONS: We demonstrate that anatomic resection is a safe and efficient method for managing this rare congenital vascular malformation...
April 2015: Transplantation Proceedings
Komal A Jakhotia, Apurv P Shimpi, Savita A Rairikar, Priyanka Mhendale, Renuka Hatekar, Ashok Shyam, Parag K Sancheti
BACKGROUND: In India, obesity is highly prevalent in women as compared to men. As the obesity epidemic spreads, there are growing concerns about efficient obesity management. AIMS: To compare between circuit training (CT), treadmill (TM) walking and suryanamaskar (SN) training in weight management and physical fitness enhancement in obese females. SETTINGS AND DESIGNS: Comparative controlled study conducted in a community setting. MATERIALS AND METHODS: 119 females of age between 20 and 40 years of body mass index (BMI) between 25...
January 2015: International Journal of Yoga
J S Sancheti, M F Shaikh, P F Khatwani, Savita R Kulkarni, Sadhana Sathaye
A new robust, simple and economic high performance thin layer chromatographic method was developed for simultaneous estimation of L-glutamic acid and γ-amino butyric acid in brain homogenate. The high performance thin layer chromatographic separation of these amino acid was achieved using n-butanol:glacial acetic acid:water (22:3:5 v/v/v) as mobile phase and ninhydrin as a derivatising agent. Quantitation of the method was achieved by densitometric method at 550 nm over the concentration range of 10-100 ng/spot...
November 2013: Indian Journal of Pharmaceutical Sciences
M F Shaikh, J Sancheti, S Sathaye
In the present study, anticonvulsant activity of methanol extract of Eclipta alba (10-200 mg/kg) was studied using pentylenetetrazole- and picrotoxin-induced seizure models. Mechanism of effect of methanol extract of Eclipta alba was further elucidated by studying its GABAA receptor modulatory activity and its effect on levels of GABA in mice brain. Methanol extract of Eclipta alba exhibited potent anticonvulsant activity but has saturation of its pharmacological activity at 50 mg/kg. At the concentration of 10 mg/ml, contractions induced in guinea pig ileum was blocked by picrotoxin, but it didn't not show any increase in GABA levels in mice brain after treatment...
May 2013: Indian Journal of Pharmaceutical Sciences
Derick Han, Maria D Ybanez, Heather S Johnson, Jeniece N McDonald, Lusine Mesropyan, Harsh Sancheti, Gary Martin, Alanna Martin, Atalie M Lim, Lily Dara, Enrique Cadenas, Hidekazu Tsukamoto, Neil Kaplowitz
Liver mitochondria undergo dynamic alterations following chronic alcohol feeding to mice. Intragastric alcohol feeding to mice resulted in 1) increased state III respiration (109% compared with control) in isolated liver mitochondria, probably due to increased levels of complexes I, IV, and V being incorporated into the respiratory chain; 2) increased mitochondrial NAD(+) and NADH levels (∼2-fold), with no change in the redox status; 3) alteration in mitochondrial morphology, with increased numbers of elongated mitochondria; and 4) enhanced mitochondrial biogenesis in the liver, which corresponded with an up-regulation of PGC-1α (peroxisome proliferator-activated receptor γ coactivator-1α)...
December 7, 2012: Journal of Biological Chemistry
M R Shah, P P Sancheti, V M Vyas, P S Karekar, Y V Pore
Proton magnetic resonance spectroscopy ((1)HNMR) studies on inclusion compounds of zaleplon with hydroxypropyl-β- cyclodextrin (HPβCD) were carried out in order to elucidate the strength and binding mode of association. Chemical shift measurements revealed that inclusion complexes of zaleplon and HPβCD were formed by penetration of aromatic rings into the HPβCD cavity from the wider rim side with deep penetration of the amide-substituted ring while inclusion of the cyano-substituted pyrazole ring was shallow...
April 2010: Drug Discoveries & Therapeutics
P P Sancheti, V M Vyas, Manali Shah, Poonam Karekar, Y V Pore
A simple, sensitive, rapid, accurate and precise spectrophotometric method has been developed for the estimation of bicalutamide in bulk and pharmaceutical dosage forms. Bicalutamide shows maximum absorbance at 272 nm with molar absorptivity of 2.3399×10(4) l/mol/cm. Beer's law was obeyed in the concentration range of 1.5-18 μg/ml. The limit of detection and limit of quantification were found to be 0.1 and 0.4 μg/ml, respectively. Results of analysis were validated statistically and by recovery studies.
November 2008: Indian Journal of Pharmaceutical Sciences
P Sancheti, M Hardikar, N Karne, J Panse, S Singh, A Maria, I Basu
OBJECTIVE: To compare the efficacy and safety of S-etodolac with etodolac in the treatment of osteoarthritis in Indian patients. MATERIALS AND METHODS: This was a double-blind, multicentric, comparative clinical trial conducted in 108 Indian patients with osteoarthritis. All patients received either S-etodolac ER 300 mg or etodolac ER 600 mg tablets once daily. Assessment was done on the basis of WOMAC score and VAS pain score, patient's and physician's global assessment of the arthritic condition...
July 2010: International Journal of Clinical Pharmacology and Therapeutics
P P Sancheti, P Karekar, V M Vyas, M Shah, Y V Pore
Solid dispersions of the poorly water-soluble drug ezetimibe were prepared with a surfactant, Pluronic 188 in different ratios and characterized by FTIR, XRD, DSC and dissolution studies. The melting method was employed to prepare the solid dispersions whereas a physical mixture (1:3) was prepared by co-grinding the individual components in a mortar. Physical studies demonstrated a significant reduction in crystallinity with a possibility of presence of amorphous character of drug in the solid dispersions of ezetimibe...
April 2009: Die Pharmazie
Manali Shah, Poonam Karekar, Pankajkumar Sancheti, Vikrant Vyas, Yogesh Pore
The effect of polyvinyl pyrrolidone (PVP) K30 and/or L-arginine on etoricoxib-HPbetaCD complex was investigated. The phase solubility profiles were classified as A(L)-type, both in absence or presence of auxiliary substances used. The apparent stability constant (K(c)) of binary complex obtained at room temperature, 371.80 +/- 2.61 M(-1), was decreased with the addition of PVP and arginine indicating no benefit of addition of auxiliary substances to promote higher complexation efficiency. Therefore, solid etoricoxib-HPbetaCD binary systems were prepared and characterized by proton nuclear magnetic resonance spectroscopy (1HNMR), X-ray powder diffractometry, Fourier transformation-infrared spectroscopy, and dissolution studies...
January 2009: Drug Development and Industrial Pharmacy
P P Sancheti, V M Vyas, M Shah, P Karekar, Y V Pore
The objective of the present work was to improve the dissolution rate of a poorly water-soluble drug, bicalutamide, by a solid dispersion technique. The solid dispersion systems of bicalutamide were prepared with poloxamer F68 in 1:1, 1:3, and 1:5 ratios using the melting method. The interaction of drug with polymer was evaluated by TLC, FTIR, and powder XRD. The results of powder XRD showed a significant decrease in the crystallinity of drug in the binary systems of bicalutamide. All binary systems of bicalutamide showed faster dissolution than pure drug alone (p < 0...
August 2008: Die Pharmazie
A Sancheti, M D White
For human exercise at intensities greater than approximately 70 to 85% of maximal levels of exertion, ventilation (V E) increases proportionately to core temperature (T C) following distinct T C thresholds. This suggested T C in humans could be a modulator of exercise-induced ventilation. This study tested the reproducibility of relationships between oesophageal temperature (T oes) ventilation and its components during incremental exercise. On two nonconsecutive days, at an ambient temperature of 22.1+/-0.3 degrees C and RH of 45+/-5%, seven untrained adult males of normal physique pedaled on a seated cycle ergometer in an incremental exercise protocol from rest to the point of exhaustion...
March 2006: European Journal of Applied Physiology
Maureen DeCenzo, Mike Kuranda, Seth Cohen, John Babiak, Zhi-Dong Jiang, Dongyu Su, Mark Hickey, Praveen Sancheti, Patricia A Bradford, Phil Youngman, Steve Projan, David M Rothstein
A screening system is described that can detect and confirm inhibitors of the late steps of cell wall biosynthesis. The primary high through-put screen monitors induction of beta-lactamase following exposure to samples, in an Escherichia coli envA- strain that carries the beta-lactamase gene from Citrobacter freundii on a plasmid. Positive samples were detected from compound libraries, from natural products libraries, and from fractions of natural products crude preparations. These samples were then subjected to in vitro assays that could detect the incorporation of soluble cell wall precursor into Lipid I, Lipid II, and polymerized cell wall, using a TLC system that was very accurate and unambiguous in detecting known cell wall inhibitors...
March 2002: Journal of Antibiotics
N Mani, P Sancheti, Z D Jiang, C McNaney, M DeCenzo, B Knight, M Stankis, M Kuranda, D M Rothstein, P Sanchet, B Knighti
We devised two screening systems to detect cell wall transglycosylation inhibitors. One screen utilizes a mutant of Enterococcus faecalis strain A256 that is dependent on vancomycin or moenomycin for growth. In the absence of transglycosylation inhibitors the strain fails to grow, while in the presence of inhibitors, cells are rescued. A second screening organism E. faecalis strain MDD212 utilizes a translational fusion of the lacZ gene to the vanH promoter in a derivative of E. faecalis that contains a vancomycin resistance determinant...
May 1998: Journal of Antibiotics
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