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https://www.readbyqxmd.com/read/29287474/practical-considerations-challenges-and-limitations-of-bioconjugation-via-azide-alkyne-cycloaddition
#1
Chad J Pickens, Stephanie N Johnson, Melissa M Pressnall, Martin Leon, Cory Berkland
Interrogating biological systems is often limited by access to biological probes. The emergence of "click chemistry" has revolutionized bioconjugate chemistry by providing facile reaction conditions amenable to both biologic molecules and small molecule probes such as fluorophores, toxins, or therapeutics. One particularly popular version is the copper-catalyzed azide-alkyne cycloaddition (AAC) reaction, which has spawned new alternatives such as the strain-promoted azide-alkyne cycloaddition reaction, among others...
December 29, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29282407/dementia-and-hospital-readmission-rates-a-systematic-review
#2
REVIEW
Sabrina Pickens, Aanand D Naik, Angela Catic, Mark E Kunik
Background: Although community-dwelling persons with dementia have an increased risk of hospital readmission, no systematic review has examined the contribution of dementia to readmissions. Summary: We examined articles in English, with no restrictions on publication dates, from Medline, PubMed, PsycINFO, CINAHL, and EMBASE. Keywords used were dementia, Alzheimer disease, frontotemporal lobar degeneration, elderly, frontotemporal dementia, executive function, brain atrophy, frontal lobe atrophy, cognitive impairment, readmission, readmit, rehospitalization, patient discharge, and return visit...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29281559/left-atrial-abnormality-laa-as-a-predictor-of-ibrutinib-associated-atrial-fibrillation-in-patients-with-chronic-lymphocytic-leukemia
#3
Anthony R Mato, Suparna Clasen, Peter Pickens, Lisa Gashonia, Joanna Rhodes, Jakub Svoboda, Mitchell Hughes, Chadi Nabhan, Naveed Ali, Stephen Schuster, Joseph Carver
Results from several recent studies in chronic lymphocytic leukemia (CLL) have demonstrated an association between ibrutinib exposure and the development of atrial fibrillation, estimated incidence of 11% with long-term follow up. This is a common cause of ibrutinib discontinuation. Risk factors for atrial fibrillation include advanced age, hypertension (HTN), mitral valve disease (MVD), left atrial remodeling, coronary artery disease (CAD) and risk factors for cardiovascular dysfunction We conducted a retrospective case control study using the presence of left atrial abnormality identified on pre-ibrutinib EKGs, defined as either (1) Lead II-bifed p wave, with 40 mcsec between peaks for ≥ 2...
December 27, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29215512/term-elective-induction-of-labor-and-pregnancy-outcomes-among-obese-women-and-their-offspring
#4
Cassandra M Gibbs Pickens, Michael R Kramer, Penelope P Howards, Martina L Badell, Aaron B Caughey, Carol J Hogue
OBJECTIVE: To evaluate whether elective induction of labor between 39 through 41 weeks of gestation, as compared with expectant management, is associated with reduced cesarean delivery and other adverse outcomes among obese women and their offspring. METHODS: We conducted a retrospective cohort study using the 2007-2011 California Linked Patient Discharge Data-Birth Cohort File of 165,975 singleton, cephalic, nonanomalous deliveries to obese women. For each gestational week (39-41), we used multivariable logistic regression models, stratified by parity, to assess whether elective induction of labor or expectant management was associated with lower odds of cesarean delivery and other adverse outcomes...
January 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29174780/hospitalization-costs-after-surgery-in-high-risk-patients-with-early-stage-lung-cancer
#5
Manu S Sancheti, Ray K Chihara, Sebastian D Perez, Onkar V Khullar, Felix G Fernandez, Allan Pickens, Seth D Force
BACKGROUND: We previously reported that early stage lung cancer patients who are considered high risk for surgery can undergo resection with favorable perioperative results and long-term mortality. To further elucidate the role of surgical resection in this patient cohort, this study evaluated the length of stay and total hospitalization cost among patients classified as standard or high risk with early stage lung cancer who underwent pulmonary resection. METHODS: A total of 490 patients from our institutional Society of Thoracic Surgeons data from 2009 to 2013 underwent resection for clinical stage I lung cancer...
November 23, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28963036/co-delivery-of-autoantigen-and-dexamethasone-in-incomplete-freund-s-adjuvant-ameliorates-experimental-autoimmune-encephalomyelitis
#6
Laura Northrup, J Daniel Griffin, Matthew A Christopher, Lorena R Antunez, Brittany L Hartwell, Chad J Pickens, Cory Berkland
Current therapies for autoimmune diseases focus on treating the symptoms rather than the underlying disease cause. A major setback in improving current therapeutics for autoimmunity is the lack of antigen specificity. Successful antigen-specific immunotherapy (ASIT) would allow for improved treatment of autoimmune diseases. In this work, dexamethasone was co-delivered with autoantigen (PLP) in vivo to create effective ASIT for the treatment of experimental autoimmune encephalomyelitis (EAE). Using an emulsion of incomplete Freund's adjuvant (IFA) as a co-delivery vehicle, it was discovered that the controlled release of autoantigen was important for the suppression of clinical disease symptoms...
September 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28944109/a-case-of-renal-metastasis-of-uterine-leiomyosarcoma
#7
Petar Bajic, William S Gange, Robert H Blackwell, Arpeet S Shah, John Biemer, Maria M Picken, Alex Gorbonos
A 49-year-old woman with a distant history of uterine leiomyosarcoma underwent robotic-assisted laparoscopic partial nephrectomy for a 3.5 cm right renal mass, which was presumed to be a primary renal cell carcinoma. Surgical margins were negative, and the histologic analysis confirmed leiomyosarcoma. Uterine leiomyosarcoma is traditionally a locally aggressive disease with only rare reports of renal involvement. We report a case of a metastatic leiomyosarcoma to the kidney four years following initial treatment for uterine leiomyosarcoma...
July 14, 2017: Curēus
https://www.readbyqxmd.com/read/28923052/accessing-physical-activity-among-young-adults-attending-a-university-the-role-of-sex-race-ethnicity-technology-use-and-sleep
#8
Samuel D Towne, Marcia G Ory, Matthew Lee Smith, S Camille Peres, Adam W Pickens, Ranjana K Mehta, Mark Benden
BACKGROUND: Identifying factors associated with recommended physical activity (PA) levels are critical in efforts to combat the obesity epidemic and related comorbidities. METHODS: We conducted cross-sectional analyses of college students (n = 490) enrolled in a large southern state university in October of 2014. Our aim was to identify sociodemographic characteristics, technology use, and sleep patterns among college students and their independent relationship to recommended PA...
September 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28906303/relationship-of-low-doses-of-alcohol-voluntarily-consumed-during-adolescence-and-early-adulthood-with-subsequent-behavioral-flexibility
#9
Hayley Fisher, Nicholas Bright, Mark Gallo, Alisa Pajser, Charles L Pickens
Previous alcohol use is associated with impaired decision-making and impulsivity in humans, but the relationship between alcohol use and decision-making/impulsivity is unclear. In two experiments, we determined whether chronic intermittent access to alcohol during adolescence and early adulthood would alter or be correlated with performance in a go/no-go reversal task, a devaluation task, or operant extinction. Rats received 6 weeks of chronic intermittent access to 20% alcohol or water from postnatal day 26 to 66 and then behavioral testing was initiated 1...
October 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28856472/reliability-of-the-participation-and-sensory-environment-questionnaire-teacher-version
#10
Aimee Piller, Tina Fletcher, Beth Pfeiffer, Karen Dunlap, Noralyn Pickens
The Participation and Sensory Environment Questionnaire-Teacher Version (PSEQ-TV) is a teacher-report questionnaire to assess the impact of the sensory environment on participation of preschool children with autism spectrum disorder (ASD). Many children with ASD have sensory processing differences, although these differences are frequently examined from the standpoint of the person. The PSEQ-TV provides a single assessment to examine both participation and the sensory environment for preschool aged children with ASD...
November 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28844803/picomolar-inhibition-of-%C3%AE-galactosidase-bovine-liver-attributed-to-loop-closure
#11
Jessica B Pickens, Feng Wang, Susanne Striegler
In an effort to examine similarities in the active sites of glycosidases within the GH35 family, we performed a structure-activity-relationship study using our recently described library of galactonoamidines. The kinetic evaluation based on UV/Vis spectroscopy disclosed inhibition of β-galactosidase (bovine liver) in the picomolar concentration range indicating significantly higher inhibitor affinity than previously determined for β-galactosidase (A. oryzae). Possible alterations in the secondary protein structure or folding were excluded after further examination of the inhibitor binding using CD spectroscopy...
October 15, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28802188/risk-of-uterine-cancer-for-brca1-and-brca2-mutation-carriers
#12
MULTICENTER STUDY
Y C Lee, R L Milne, S Lheureux, M Friedlander, S A McLachlan, K L Martin, M Q Bernardini, C Smith, S Picken, S Nesci, J L Hopper, K A Phillips
BACKGROUND: Whether BRCA1 and BRCA2 mutation carriers have a clinically relevant elevated risk of uterine cancer has implications for risk-reducing surgery. AIM: This multicentre, prospective cohort study assessed uterine cancer risk for mutation carriers compared with the general population. METHODS: Eligible mutation carriers were enrolled in the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab) cohort study, had a uterus present and no history of uterine cancer at cohort entry...
October 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28760303/analysis-of-efficacy-and-tolerability-of-bruton-tyrosine-kinase-inhibitor-ibrutinib-in-various-b-cell-malignancies-in-the-general-community-a%C3%A2-single-center-experience
#13
Naveed Ali, Faizan Malik, Syed Imran Mustafa Jafri, Mary Naglak, Mark Sundermeyer, Peter V Pickens
BACKGROUND: Ibrutinib, an irreversible inhibitor of Bruton tyrosine kinase (BTK), is a novel drug that has shown significant efficacy and survival benefit for treatment of various B-cell malignancies. The primary objective of the present study was to investigate the efficacy of ibrutinib therapy in various B-cell malignancies in the general community. The secondary objectives included studying the adverse effects, ibrutinib-induced peripheral lymphocytosis, and effect on immunoglobulin levels...
July 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28740130/obesity-adipokines-and-c-peptide-are-associated-with-distinct-plasma-phospholipid-profiles-in-adult-males-an-untargeted-lipidomic-approach
#14
C Austin Pickens, Ana I Vazquez, A Daniel Jones, Jenifer I Fenton
Obesity is associated with dysregulated lipid metabolism and adipokine secretion. Our group has previously reported obesity and adipokines are associated with % total fatty acid (FA) differences in plasma phospholipids. The objective of our current study was to identify in which complex lipid species (i.e., phosphatidylcholine, sphingolipids, etc) these FA differences occur. Plasma lipidomic profiling (n = 126, >95% Caucasian, 48-65 years) was performed using chromatographic separation and high resolution tandem mass spectrometry...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28697636/increasing-dietary-epa-and-dha-influence-estimated-fatty-acid-desaturase-activity-in-systemic-organs-which-is-reflected-in-the-red-blood-cell-in-mice
#15
Emily A Davidson, C Austin Pickens, Jenifer I Fenton
Delta-5 (D5D) and delta-6 (D6D) desaturase are key enzymes in fatty acid (FA) metabolism. Dietary eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may alter tissue FA composition via D5D and D6D. The purpose was to determine the relationship between dietary EPA + DHA, estimated desaturase activities of various tissues and the reflection of desaturase activity in the red blood cell (RBC). Mice were fed diets with increasing percent of energy from EPA + DHA. Phospholipid FA composition of heart, muscle, spleen, lung, adipose tissues and RBC were analysed...
July 11, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28686529/identifying-cognitive-impairment-in-hospitalized-older-adults-to-prevent-readmission-two-case-studies
#16
Sabrina Pickens, Lisa Boss, Hyochol Ahn, Felicia Jefferson
OBJECTIVE: To describe two patient outcomes post-discharge from an acute hospital admission. Both patients underwent cognitive testing during hospitalization. METHODS: A battery of cognitive tests was administered to two hospitalized older adult patients. Both patients were evaluated in their homes within 72 hours of discharge and again at 14- and 30-days by a nurse practitioner. RESULTS: One of the patients was readmitted within 30 days of hospital discharge due to complications from an amputation...
May 25, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28661387/caregiver-perceptions-of-a-telehealth-wellness-program
#17
Katrina M Serwe, Gayle I Hersch, Noralyn Davel Pickens, Karen Pancheri
OBJECTIVE: We sought to understand caregivers' experience of an education-based wellness program delivered using telehealth. METHOD: In this qualitative pilot study, 4 caregivers participated in a focus group after completing a 6-wk telehealth program. Data analysis involved open coding, thematic analysis, and coding triangulation. RESULTS: Two major themes emerged. The first, "I feel like I am now prepared," included the subthemes of strategies for caregiver self-maintenance, the understanding that caregiving is a normal process, and the value of a group experience...
July 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28571456/microchannel-plate-detector-detection-efficiency-to-monoenergetic-electrons-between-3-and-28-kev
#18
Ryan C Blase, Roland R Benke, Gregory P Miller, Keith S Pickens, J Hunter Waite
An unshielded microchannel plate (MCP) detector with an ultrafine pore diameter of 2 μm was irradiated by an electron beam to determine the detection efficiency of electrons for creating detector signals, or counts. Tested electron energies spanned a range of 3 kiloelectron volts (keV) to 28 keV. Higher detection efficiencies were measured at the lower end of this energy range, 0.376 counts per incident electron at 3 keV down to 0.155 at 15 keV with an increase to 0.217 at 18 keV and then another decrease down to 0...
May 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28483154/pilot-study-to-integrate-patient-reported-outcomes-after-lung-cancer-operations-into-the-society-of-thoracic-surgeons-database
#19
MULTICENTER STUDY
Onkar V Khullar, Mohammed H Rajaei, Seth D Force, Jose N Binongo, Yi Lasanajak, Scott Robertson, Allan Pickens, Manu S Sancheti, Joseph Lipscomb, Theresa W Gillespie, Felix G Fernandez
BACKGROUND: A critical gap in The Society of Thoracic Surgeons (STS) Database is the absence of patient-reported outcomes (PRO), which are of increasing importance in outcomes and performance measurement. Our aim was to demonstrate the feasibility of integrating PRO into the STS Database for patients undergoing lung cancer operations. METHODS: The National Institutes of Health Patient Reported Outcome Measurement Information System (PROMIS) includes reliable, precise measures of PRO...
July 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28474886/multivalent-soluble-antigen-arrays-exhibit-high-avidity-binding-and-modulation-of-b-cell-receptor-mediated-signaling-to-drive-efficacy-against-experimental-autoimmune-encephalomyelitis
#20
Brittany L Hartwell, Chad J Pickens, Martin Leon, Cory Berkland
A pressing need exists for antigen-specific immunotherapies (ASIT) that induce selective tolerance in autoimmune disease while avoiding deleterious global immunosuppression. Multivalent soluble antigen arrays (SAgAPLP:LABL), consisting of a hyaluronic acid (HA) linear polymer backbone cografted with multiple copies of autoantigen (PLP) and cell adhesion inhibitor (LABL) peptides, are designed to induce tolerance to a specific multiple sclerosis (MS) autoantigen. Previous studies established that hydrolyzable SAgAPLP:LABL, employing a degradable linker to codeliver PLP and LABL, was therapeutic in experimental autoimmune encephalomyelitis (EAE) in vivo and exhibited antigen-specific binding with B cells, targeted the B cell receptor (BCR), and dampened BCR-mediated signaling in vitro...
May 17, 2017: Biomacromolecules
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