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https://www.readbyqxmd.com/read/29791838/dorsolateral-striatum-engagement-interferes-with-early-discrimination-learning
#1
Hadley C Bergstrom, Anna M Lipkin, Abby G Lieberman, Courtney R Pinard, Ozge Gunduz-Cinar, Emma T Brockway, William W Taylor, Mio Nonaka, Olena Bukalo, Tiffany A Wills, F Javier Rubio, Xuan Li, Charles L Pickens, Danny G Winder, Andrew Holmes
In current models, learning the relationship between environmental stimuli and the outcomes of actions involves both stimulus-driven and goal-directed systems, mediated in part by the DLS and DMS, respectively. However, though these models emphasize the importance of the DLS in governing actions after extensive experience has accumulated, there is growing evidence of DLS engagement from the onset of training. Here, we used in vivo photosilencing to reveal that DLS recruitment interferes with early touchscreen discrimination learning...
May 22, 2018: Cell Reports
https://www.readbyqxmd.com/read/29770853/predominantly-cystic-clear-cell-renal-cell-carcinoma-and-multilocular-cystic-renal-neoplasm-of-low-malignant-potential-form-a-low-grade-spectrum
#2
Maria Tretiakova, Vikas Mehta, Masha Kocherginsky, Agata Minor, Steven S Shen, Sahussapont Joseph Sirintrapun, Jorge L Yao, Isabel Alvarado-Cabrero, Tatjana Antic, Scott E Eggener, Maria M Picken, Gladell P Paner
Multilocular cystic renal cell carcinoma has been recently excluded from clear cell renal cell carcinoma (CCRCC) category and re-designated as multilocular cystic renal neoplasm of low malignant potential (MCRNLMP) due to its uniformly good outcomes. While strict distinction between MCRNLMP from predominantly cystic CCRCC (pc-CCRCC) is being emphasized, the significance of extensive true cystic component in CCRCC has not been investigated. Herein, we analyzed 57 MCRNLMP, 69 pc-CCRCC, and 46 non-cystic CCRCC...
May 17, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29694912/individual-differences-in-conditioned-fear-are-associated-with-levels-of-adolescent-early-adult-alcohol-consumption-and-instrumental-extinction
#3
Alisa Pajser, Morgan Breen, Hayley Fisher, Charles L Pickens
Previous research has shown a relationship between alcohol exposure and conditioned fear, but the nature of this relationship remains unclear. We determined whether chronic intermittent access to alcohol during adolescence and early adulthood would alter or be associated with the level of conditioned fear to an auditory cue in male Long Evans rats. Rats received 6 weeks of chronic intermittent access to 20% alcohol or water from PND 26-66 and began behavioral testing 10 days later. We found no evidence that voluntary alcohol consumption altered fear...
April 22, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29605789/the-role-of-the-lipidome-in-obesity-mediated-colon-cancer-risk
#4
REVIEW
Raghav Jain, C Austin Pickens, Jenifer I Fenton
Obesity is a state of chronic inflammation influenced by lipids such as fatty acids and their secondary oxygenated metabolites deemed oxylipids. Many such lipid mediators serve as potent signaling molecules of inflammation, which can further alter lipid metabolism and lead to carcinogenesis. For example, sphingosine-1-phosphate activates cyclooxygenase-2 in endothelial cells resulting in the conversion of arachidonic acid (AA) to prostaglandin E2 (PGE2 ). PGE2 promotes colon cancer cell growth. In contrast, the less studied path of AA oxygenation via cytochrome p450 enzymes produces epoxyeicosatetraenoic acids (EETs), whose anti-inflammatory properties cause shrinking of enlarged adipocytes, a characteristic of obesity, through the liberation of fatty acids...
March 2, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29543789/notes-from-the-field-assessing-rabies-risk-after-a-mass-bat-exposure-at-a-research-facility-in-a-national-park-wyoming-2017
#5
Andrea Cote, Sarah Anne J Guagliardo, Cuc H Tran, Maria A Said, Veronica Pickens, Karl Musgrave, Ryan Wallace
No abstract text is available yet for this article.
March 16, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29494645/association-of-whole-blood-n-6-fatty-acids-with-stunting-in-2-to-6-year-old-northern-ghanaian-children-a-cross-sectional-study
#6
Mary Adjepong, C Austin Pickens, Raghav Jain, William S Harris, Reginald A Annan, Jenifer I Fenton
In Northern Ghana, 33% of children are stunted due to economic disparities. Dietary fatty acids (FA) are critical for growth, but whether blood FA levels are adequate in Ghanaian children is unknown. The objective of this study was to determine the association between whole blood FAs and growth parameters in Northern Ghanaian children 2-6 years of age. A drop of blood was collected on an antioxidant treated card and analyzed for FA composition. Weight and height were measured and z-scores were calculated. Relationships between FAs and growth parameters were analyzed by Spearman correlations, linear regressions, and factor analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29487547/designing-a-summer-transition-program-for-incoming-and-current-college-students-on-the-autism-spectrum-a-participatory-approach
#7
Emily Hotez, Christina Shane-Simpson, Rita Obeid, Danielle DeNigris, Michael Siller, Corinna Costikas, Jonathan Pickens, Anthony Massa, Michael Giannola, Joanne D'Onofrio, Kristen Gillespie-Lynch
Students with Autism Spectrum Disorder (ASD) face unique challenges transitioning from high school to college and receive insufficient support to help them navigate this transition. Through a participatory collaboration with incoming and current autistic college students, we developed, implemented, and evaluated two intensive week-long summer programs to help autistic students transition into and succeed in college. This process included: (1) developing an initial summer transition program curriculum guided by recommendations from autistic college students in our ongoing mentorship program, (2) conducting an initial feasibility assessment of the curriculum [Summer Transition Program 1 (STP1)], (3) revising our initial curriculum, guided by feedback from autistic students, to develop a curriculum manual, and (4) pilot-testing the manualized curriculum through a quasi-experimental pre-test/post-test assessment of a second summer program [Summer Transition Program 2 (STP2)]...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29402166/in-home-contextual-reality-a-qualitative-analysis-using-the-multiple-errands-test-home-version-met-home
#8
Suzanne Perea Burns, Noralyn Davel Pickens, Deirdre R Dawson, Jaimee D Perea, Asha K Vas, Carlos Marquez de la Plata, Marsha Neville
Adults with stroke frequently experience executive dysfunction. Despite the range of assessments that examine the effects of executive dysfunction on daily tasks, there remains a paucity of literature that examines the influence of the environment on performance in the community. The MET-Home is an ecologically valid assessment for examining post-stroke executive dysfunction in the home environment. This qualitative study explores the relationship between the environment and MET-Home performance among home-dwelling adults with stroke and matched controls...
February 6, 2018: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29361733/verdinexor-targeting-of-crm1-is-a-promising-therapeutic-approach-against-rsv-and-influenza-viruses
#9
REVIEW
Jennifer A Pickens, Ralph A Tripp
Two primary causes of respiratory tract infections are respiratory syncytial virus (RSV) and influenza viruses, both of which remain major public health concerns. There are a limited number of antiviral drugs available for the treatment of RSV and influenza, each having limited effectiveness and each driving selective pressure for the emergence of drug-resistant viruses. Novel broad-spectrum antivirals are needed to circumvent problems with current disease intervention strategies, while improving the cytokine-induced immunopathology associated with RSV and influenza infections...
January 21, 2018: Viruses
https://www.readbyqxmd.com/read/29355927/early-impact-of-the-affordable-care-act-coverage-expansion-on-safety-net-hospital-inpatient-payer-mix-and-market-shares
#10
Vivian Y Wu, Kathryn R Fingar, H Joanna Jiang, Raynard Washington, Andrew W Mulcahy, Eli Cutler, Gary Pickens
OBJECTIVE: To examine the impact of the Affordable Care Act's coverage expansion on safety-net hospitals (SNHs). STUDY SETTING: Nine Medicaid expansion states. STUDY DESIGN: Differences-in-differences (DID) models compare payer-specific pre-post changes in inpatient stays of adults aged 19-64 years at SNHs and non-SNHs. DATA COLLECTION METHODS: 2013-2014 Healthcare Cost and Utilization Project State Inpatient Databases...
January 21, 2018: Health Services Research
https://www.readbyqxmd.com/read/29353731/evaluating-hydrophobic-galactonoamidines-as-transition-state-analogs-for-enzymatic-%C3%AE-galactoside-hydrolysis
#11
Jessica B Pickens, Logan G Mills, Feng Wang, Susanne Striegler
A spectroscopic examination of six galactonoamidines with inhibition constants and efficacy in the low nanomolar concentration range (Ki  = 6-11 nM, IC50  = 12-36 nM) suggested only two of them as putative transition state analogs for the hydrolysis of β-galactosides by β-galactosidase (A. oryzae). A rationale for the experimental results was elaborated using docking and molecular dynamics studies. An analysis of the combined observations reveals several common factors of the compounds suggested as transition state analogs (TSAs): the putative TSAs have a similar orientation in the active site; show conserved positioning of the glycon; display a large number of H-bond interactions toward the catalytically active amino acid residues via their glycon; and exhibit hydrophobic interactions at the outer rim of the active site with small changes of the position and orientation of their respective aglycons...
April 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29287474/practical-considerations-challenges-and-limitations-of-bioconjugation-via-azide-alkyne-cycloaddition
#12
Chad J Pickens, Stephanie N Johnson, Melissa M Pressnall, Martin A Leon, Cory J Berkland
Interrogating biological systems is often limited by access to biological probes. The emergence of "click chemistry" has revolutionized bioconjugate chemistry by providing facile reaction conditions amenable to both biologic molecules and small molecule probes such as fluorophores, toxins, or therapeutics. One particularly popular version is the copper-catalyzed azide-alkyne cycloaddition (AAC) reaction, which has spawned new alternatives such as the strain-promoted azide-alkyne cycloaddition reaction, among others...
March 21, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29282407/dementia-and-hospital-readmission-rates-a-systematic-review
#13
REVIEW
Sabrina Pickens, Aanand D Naik, Angela Catic, Mark E Kunik
Background: Although community-dwelling persons with dementia have an increased risk of hospital readmission, no systematic review has examined the contribution of dementia to readmissions. Summary: We examined articles in English, with no restrictions on publication dates, from Medline, PubMed, PsycINFO, CINAHL, and EMBASE. Keywords used were dementia , Alzheimer disease , frontotemporal lobar degeneration , elderly , frontotemporal dementia , executive function , brain atrophy , frontal lobe atrophy , cognitive impairment , readmission , readmit , rehospitalization , patient discharge , and return visit ...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29281559/left-atrial-abnormality-laa-as-a-predictor-of-ibrutinib-associated-atrial-fibrillation-in-patients-with-chronic-lymphocytic-leukemia
#14
Anthony R Mato, Suparna Clasen, Peter Pickens, Lisa Gashonia, Joanna Rhodes, Jakub Svoboda, Mitchell Hughes, Chadi Nabhan, Naveed Ali, Stephen Schuster, Joseph Carver
Results from several recent studies in chronic lymphocytic leukemia (CLL) have demonstrated an association between ibrutinib exposure and the development of atrial fibrillation, estimated incidence of 11% with long-term follow up. This is a common cause of ibrutinib discontinuation. Risk factors for atrial fibrillation include advanced age, hypertension (HTN), mitral valve disease (MVD), left atrial remodeling, coronary artery disease (CAD) and risk factors for cardiovascular dysfunction We conducted a retrospective case control study using the presence of left atrial abnormality identified on pre-ibrutinib EKGs, defined as either (1) Lead II-bifed p wave, with 40 mcsec between peaks for ≥ 2...
January 2, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29215512/term-elective-induction-of-labor-and-pregnancy-outcomes-among-obese-women-and-their-offspring
#15
COMPARATIVE STUDY
Cassandra M Gibbs Pickens, Michael R Kramer, Penelope P Howards, Martina L Badell, Aaron B Caughey, Carol J Hogue
OBJECTIVE: To evaluate whether elective induction of labor between 39 through 41 weeks of gestation, as compared with expectant management, is associated with reduced cesarean delivery and other adverse outcomes among obese women and their offspring. METHODS: We conducted a retrospective cohort study using the 2007-2011 California Linked Patient Discharge Data-Birth Cohort File of 165,975 singleton, cephalic, nonanomalous deliveries to obese women. For each gestational week (39-41), we used multivariable logistic regression models, stratified by parity, to assess whether elective induction of labor or expectant management was associated with lower odds of cesarean delivery and other adverse outcomes...
January 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29174780/hospitalization-costs-after-surgery-in-high-risk-patients-with-early-stage-lung-cancer
#16
COMPARATIVE STUDY
Manu S Sancheti, Ray K Chihara, Sebastian D Perez, Onkar V Khullar, Felix G Fernandez, Allan Pickens, Seth D Force
BACKGROUND: We previously reported that early stage lung cancer patients who are considered high risk for surgery can undergo resection with favorable perioperative results and long-term mortality. To further elucidate the role of surgical resection in this patient cohort, this study evaluated the length of stay and total hospitalization cost among patients classified as standard or high risk with early stage lung cancer who underwent pulmonary resection. METHODS: A total of 490 patients from our institutional Society of Thoracic Surgeons data from 2009 to 2013 underwent resection for clinical stage I lung cancer...
January 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28963036/co-delivery-of-autoantigen-and-dexamethasone-in-incomplete-freund-s-adjuvant-ameliorates-experimental-autoimmune-encephalomyelitis
#17
Laura Northrup, J Daniel Griffin, Matthew A Christopher, Lorena R Antunez, Brittany L Hartwell, Chad J Pickens, Cory Berkland
Current therapies for autoimmune diseases focus on treating the symptoms rather than the underlying disease cause. A major setback in improving current therapeutics for autoimmunity is the lack of antigen specificity. Successful antigen-specific immunotherapy (ASIT) would allow for improved treatment of autoimmune diseases. In this work, dexamethasone was co-delivered with autoantigen (PLP) in vivo to create effective ASIT for the treatment of experimental autoimmune encephalomyelitis (EAE). Using an emulsion of incomplete Freund's adjuvant (IFA) as a co-delivery vehicle, it was discovered that the controlled release of autoantigen was important for the suppression of clinical disease symptoms...
November 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28944109/a-case-of-renal-metastasis-of-uterine-leiomyosarcoma
#18
Petar Bajic, William S Gange, Robert H Blackwell, Arpeet S Shah, John Biemer, Maria M Picken, Alex Gorbonos
A 49-year-old woman with a distant history of uterine leiomyosarcoma underwent robotic-assisted laparoscopic partial nephrectomy for a 3.5 cm right renal mass, which was presumed to be a primary renal cell carcinoma. Surgical margins were negative, and the histologic analysis confirmed leiomyosarcoma. Uterine leiomyosarcoma is traditionally a locally aggressive disease with only rare reports of renal involvement. We report a case of a metastatic leiomyosarcoma to the kidney four years following initial treatment for uterine leiomyosarcoma...
July 14, 2017: Curēus
https://www.readbyqxmd.com/read/28923052/accessing-physical-activity-among-young-adults-attending-a-university-the-role-of-sex-race-ethnicity-technology-use-and-sleep
#19
Samuel D Towne, Marcia G Ory, Matthew Lee Smith, S Camille Peres, Adam W Pickens, Ranjana K Mehta, Mark Benden
BACKGROUND: Identifying factors associated with recommended physical activity (PA) levels are critical in efforts to combat the obesity epidemic and related comorbidities. METHODS: We conducted cross-sectional analyses of college students (n = 490) enrolled in a large southern state university in October of 2014. Our aim was to identify sociodemographic characteristics, technology use, and sleep patterns among college students and their independent relationship to recommended PA...
September 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28906303/relationship-of-low-doses-of-alcohol-voluntarily-consumed-during-adolescence-and-early-adulthood-with-subsequent-behavioral-flexibility
#20
Hayley Fisher, Nicholas Bright, Mark Gallo, Alisa Pajser, Charles L Pickens
Previous alcohol use is associated with impaired decision-making and impulsivity in humans, but the relationship between alcohol use and decision-making/impulsivity is unclear. In two experiments, we determined whether chronic intermittent access to alcohol during adolescence and early adulthood would alter or be correlated with performance in a go/no-go reversal task, a devaluation task, or operant extinction. Rats received 6 weeks of chronic intermittent access to 20% alcohol or water from postnatal day 26 to 66 and then behavioral testing was initiated 1...
October 2017: Behavioural Pharmacology
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