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M Padala

Krista L Lanctôt, Luis Agüera-Ortiz, Henry Brodaty, Paul T Francis, Yonas E Geda, Zahinoor Ismail, Gad A Marshall, Moyra E Mortby, Chiadi U Onyike, Prasad R Padala, Antonios M Politis, Paul B Rosenberg, Emma Siegel, David L Sultzer, Eleenor H Abraham
INTRODUCTION: Apathy is common in neurocognitive disorders (NCDs) such as Alzheimer's disease and mild cognitive impairment. Although the definition of apathy is inconsistent in the literature, apathy is primarily defined as a loss of motivation and decreased interest in daily activities. METHODS: The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) Neuropsychiatric Syndromes Professional Interest Area (NPS-PIA) Apathy workgroup reviewed the latest research regarding apathy in NCDs...
June 27, 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Surendra K Chawla, Weiwei Shi, Bryant V McIver, Jakob Vinten-Johansen, Robert W M Frater, Muralidhar Padala
Surgical repair of flail mitral valve leaflets with neochordoplasty has good outcomes, but implementing it in anterior and bi-leaflet leaflet repair is challenging. Placing and sizing individual neochordae is time consuming and error prone, with persistent localized flail if performed incorrectly. In this study, we report our pre-clinical experience with a novel multi-chordal patch for mitral valve repair. The device was designed based on human cadaver hearts, and laser cut from expanded polytetrafluoroethylene...
April 2016: Journal of Cardiovascular Translational Research
Santosh K Padala, Mandeep S Sidhu, Jeremiah R Brown, Jonathan S Zipursky, David A Steckman, Dhaval R Parikh, Mark L Greenberg
AIMS: The electrocardiographic (ECG) signs used to differentiate ventricular tachycardia (VT) from supraventricular tachycardia (SVT) with aberrancy are specific but not highly sensitive. The purpose of this study was to define the utility of an underappreciated form of atrioventricular (AV) dissociation at the onset of tachycardia, a single dissociated P wave, in the differentiation of non-sustained monomorphic wide complex tachycardia (WCT) in hospitalized patients. METHODS AND RESULTS: We prospectively analysed tracings from 102 consecutive hospitalized patients who had an episode of non-sustained (≥5 beats, <30 s), monomorphic, WCT (≥100 b...
July 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Santosh K Padala, Mandeep S Sidhu, Pamela M Hartigan, David J Maron, Koon K Teo, John A Spertus, G B John Mancini, Steven P Sedlis, Bernard R Chaitman, Gary V Heller, William S Weintraub, William E Boden
The impact of baseline exercise capacity on clinical outcomes in patients with stable ischemic heart disease randomized to an initial strategy of optimal medical therapy (OMT) with or without percutaneous coronary intervention (PCI) in the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial has not been studied. A post hoc analysis was performed in 1,052 patients of COURAGE (PCI + OMT: n = 527, OMT: n = 525) who underwent exercise treadmill testing at baseline. Patients were categorized into 2 exercise capacity groups based on metabolic equivalents (METs) achieved during baseline exercise treadmill testing (<7 METs: n = 464, ≥7 METs: n = 588) and were followed for a median of 4...
November 15, 2015: American Journal of Cardiology
Richard A Dennis, Usha Ponnappan, Ralph L Kodell, Kimberly K Garner, Christopher M Parkes, Melinda M Bopp, Kalpana P Padala, Charlotte A Peterson, Prasad R Padala, Dennis H Sullivan
BACKGROUND: Immune function may influence the ability of older adults to maintain or improve muscle mass, strength, and function during aging. Thus, nutritional supplementation that supports the immune system could complement resistance exercise as an intervention for age-associated muscle loss. The current study will determine the relationship between immune function and exercise training outcomes for older adults who consume a nutritional supplement or placebo during resistance training and post-training follow-up...
2015: Trials
Santhoshi Rani Nanchari, Anuradha Cingeetham, Phannibhushann Meka, Surekha Damineni, Nageshwarao Tipirisetti, Chiranjeevi Padala, Sandhya Annamaneni, Surekha Rani Hanumanth, Raghunadha Rao Digumarthi, Vishnupriya Satti
Rrp1B (ribosomal RNA processing1 homolog B) is a novel candidate metastasis modifier gene in breast cancer. Functional gene assays demonstrated that a physical and functional interaction existing between Rrp1b and metastasis modifier gene SIPA1 causes reduction in the tumor growth and metastatic potential. Ectopic expression of Rrp1B modulates various metastasis predictive extra cellular matrix (ECM) genes associated with tumor suppression. The aim of this study is to determine the functional significance of single nucleotide polymorphism (SNP) in human Rrp1B gene (1307 T>C; rs9306160) with breast cancer development and progression...
February 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Santosh K Padala, Abhijit Ghatak, Sandeep Padala, Deborah M Katten, Donna M Polk, Gary V Heller
BACKGROUND: Previous studies have demonstrated that diabetic patients undergoing exercise stress single-photon emission-computed tomography (SPECT) myocardial perfusion imaging (MPI) have significantly lower cardiac events when compared to the diabetic patients undergoing pharmacologic stress SPECT MPI across all perfusion categories. However, there are limited data on the level of exercise achieved during exercise SPECT MPI among diabetic patients and its impact on cardiovascular outcomes...
December 2014: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Michele Miragoli, Magdi H Yacoub, Ismail El-Hamamsy, Jose L Sanchez-Alonso, Alexey Moshkov, Napachanok Mongkoldhumrongkul, Muralindar Padala, Saravanan Paramagurunathan, Padmini Sarathchandra, Yuri E Korchev, Julia Gorelik, Adrian H Chester
Aortic valve endothelial cells (ECs) function in vastly different levels of shear stress. The biomechanical characteristics of cells on each side of valve have not been investigated. We assessed the morphology and mechanical properties of cultured or native valve ECs on intact porcine aortic valve cusps using a scanning ion conductance microscope (SICM). The autocrine influence of several endothelial-derived mediators on cell compliance and the expression of actin were also examined. Cells on the aortic side of the valve are characterized by a more elongated shape and were aligned along a single axis...
July 1, 2014: American Journal of Physiology. Heart and Circulatory Physiology
Vinod H Thourani, Rebecca L Gunter, Stuart Hurst, Patrick Kilgo, Murali Padala, John D Puskas, Omar M Lattouf, Michael E Halkos, Robert A Guyton
BACKGROUND AND AIM OF THE STUDY: Short-term postoperative warfarin therapy has been used to decrease neurologic events following mitral valve repair or bioprosthetic replacement (MVR). The study aim was to compare the short- and long-term outcomes of patients undergoing mitral valve surgery with or without short-term postoperative warfarin. METHODS: A single academic US institution retrospective review was performed on discharged patients who underwent MVR between January 1996 and March 2010...
September 2013: Journal of Heart Valve Disease
Abhijit Ghatak, Santosh Padala, Deborah M Katten, Donna M Polk, Gary V Heller
BACKGROUND: Previous studies have suggested that diabetic patients undergoing single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) are at greater risk for cardiac events than non-diabetic patients with both normal and abnormal imaging results. However, the impact of stress modality on outcomes in this patient group has not been examined. METHODS: The data on all patients undergoing exercise stress or vasodilator stress SPECT MPI from 1996 to 2005 were reviewed...
August 2013: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Giselles Acevedo, Nischal K Padala, Li Ni, G M Jonakait
Murine microglia cultured in isolation were treated sequentially with granulocyte/monocyte colony-stimulating factor (GM-CSF) (5 days) and lipopolysaccharide (LPS) (2 days) to elicit a mature dendritic cell-like (DC-like) phenotype. Examined by flow cytometry microglia thus isolated show high surface expression of CD11c together with the co-stimulatory molecules CD40, CD80, and CD86 that are necessary for T-cell activation. In contrast, microglia co-cultured with astrocytes fail to achieve a mature DC-like phenotype...
May 2013: Journal of Neurochemistry
Dennis H Sullivan, Larry E Johnson, Richard A Dennis, Paula K Roberson, Kimberly K Garner, Prasad R Padala, Kalpana P Padala, Melinda M Bopp
BACKGROUND: It is unclear whether serial measures of body weight are valid indicators of nutritional status in older patients recovering from illness. Objectives. Investigate the relative influence of nutrient intake and changes in peripheral edema on weight change. METHODS: A prospective cohort study of 404 older men (mean age = 78.7±7.5 years) admitted to a transitional care unit of a Department of Veterans Affairs nursing home. Body weight and several indicators of lower extremity edema were measured at both unit admission and discharge...
June 2013: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Richard A Dennis, Larry E Johnson, Paula K Roberson, Muhannad Heif, Melinda M Bopp, Kimberly K Garner, Kalpana P Padala, Prasad R Padala, Patricia M Dubbert, Dennis H Sullivan
OBJECTIVES: To determine the relationships between physical function, systemic inflammation, and nutrient intake in elderly adults who are deconditioned or recovering from medical illness. DESIGN: Prospective observational study. SETTING: Recuperative care and rehabilitation setting of a Veterans Affairs hospital. PARTICIPANTS: Older adults assessed to be in need of and likely to benefit from specialized inpatient care (N = 336, aged 78...
December 2012: Journal of the American Geriatrics Society
Kalpana P Padala, Prasad R Padala, Timothy R Malloy, Jenenne A Geske, Patricia M Dubbert, Richard A Dennis, Kimberly K Garner, Melinda M Bopp, William J Burke, Dennis H Sullivan
Objectives. To determine the effects on balance and gait of a Wii-Fit program compared to a walking program in subjects with mild Alzheimer's dementia (AD). Methods. A prospective randomized (1 : 1) pilot study with two intervention arms was conducted in an assisted living facility with twenty-two mild AD subjects. In both groups the intervention occurred under supervision for 30 minutes daily, five times a week for eight weeks. Repeated measures ANOVA and paired t-tests were used to analyze changes. Results...
2012: Journal of Aging Research
Ted R Mikuls, Prasad R Padala, Harlan R Sayles, Fang Yu, Kaleb Michaud, Liron Caplan, Gail S Kerr, Andreas Reimold, Grant W Cannon, J Steuart Richards, Deana Lazaro, Geoffrey M Thiele, Joseph A Boscarino
OBJECTIVE: To examine the relationship between posttraumatic stress disorder (PTSD) and disease activity in US veterans with rheumatoid arthritis (RA). METHODS: US veterans with RA were enrolled in a longitudinal observational study and were categorized as having PTSD, other anxiety/depression disorders, or neither of these psychiatric diagnoses using administrative codes. Generalized linear mixed-effects models were used to examine the associations of the diagnostic groups with outcomes measured over a mean followup period of 3...
February 2013: Arthritis Care & Research
Smita Padala, Hocine Tighiouart, Lesley A Inker, Gabriel Contreras, Gerald J Beck, Julia Lewis, Michael Steffes, Roger A Rodby, Christopher H Schmid, Andrew S Levey
BACKGROUND: Change in glomerular filtration rate (GFR) is important for clinical decision making. GFR estimates from serum creatinine level provide an unbiased but imprecise estimate of GFR at single time points. However, the accuracy of estimated GFR over time is not well known. STUDY DESIGN: Longitudinal study of diagnostic test accuracy. SETTINGS & PARTICIPANTS: 4 clinical trials with longitudinal measurements of GFR and serum creatinine on the same day, including individuals with and without kidney disease with a wide range of kidney function, diverse racial backgrounds, and varied clinical characteristics...
August 2012: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Ramakrishna Nirogi, Vishwottam Kandikere, Prashanth Komarneni, Raghupathi Aleti, Nagasuryaprakash Padala, Ilayaraja Kalaikadhiban, Gopinadh Bhyrapuneni, Nageswararao Muddana
A high-performance liquid chromatography/positive ion electrospray tandem mass spectrometry method for the simultaneous quantification of lamivudine, stavudine and nevirapine was developed and validated in dried blood spot (DBS) cards. The analytes were separated using an isocratic mobile phase on a reverse phase column and analyzed by MS/MS in the MRM mode using the respective [M + H]⁺ ions, m/z 230-112 for lamivudine, m/z 225-127 for stavudine, m/z 267-226 for nevirapine, m/z 383-337 for zidovudine (IS)...
December 2012: Biomedical Chromatography: BMC
Ramakrishna Nirogi, Vishwottam Kandikere, Prashanth Komarneni, Raghupathi Aleti, Nagasuryaprakash Padala, Ilayaraja Kalaikadhiban
A sensitive high-performance liquid chromatography-positive ion electrospray tandem mass spectrometry method was developed and validated for the quantification of ambrisentan in plasma. The analyte and the internal standard (armodafinil) were extracted from plasma by acetonitrile precipitation and they were separated on a reversed-phase C(18) column with a gradient program. The MS acquisition was performed with multiple reaction monitoring mode using the respective [M + H](+) ions, m/z 379-347 for ambrisentan and m/z 274-167 for the IS...
October 2012: Biomedical Chromatography: BMC
Kartik Balachandran, Samiya Hussain, Choon-Hwai Yap, Muralidhar Padala, Adrian H Chester, Ajit P Yoganathan
INTRODUCTION: Serotonin/5-hydroxytryptamine (5-HT) has been implicated in valve disease and in the modulation of valve mechanical properties. Several 5-HT receptor subtypes are also known to be mechanosensitive in other cell types, but this has not been studied in the context of the valve. In this study, we sought to understand the effects of elevated 5-HT levels and stretch overload on aortic valve remodeling and the dominant 5-HT receptor subtype that regulates these processes. METHODS AND RESULTS: Collagen biosynthesis and tissue mechanical properties of porcine aortic valve cusps were evaluated after 10% (physiologic) and 15% (pathologic) dynamic stretch...
May 2012: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
Ramakrishna Nirogi, Vishwottam Kandikere, Prashanth Komarneni, Raghupathi Aleti, Nagasuryaprakash Padala, Ilayaraja Kalaikadiban
A simple and economical high-performance liquid chromatography-positive ion electrospray tandem mass spectrometry method was developed and validated for the quantification of cinacalcet in plasma. Following liquid-liquid extraction, the analyte was separated using an isocratic mobile phase on a reversed-phase column and analyzed by MS/MS in the multiple reaction monitoring mode using the respective [M+H]⁺ ions, m/z 358-155 for cinacalcet and m/z 310-148 for the internal standard. The assay exhibited a linear dynamic range of 0...
September 10, 2011: Journal of Pharmaceutical and Biomedical Analysis
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