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M Padala

S S Padala, M A Kiresur, A Ananthaneni, V S Guduru, H K Puneeth, B Bhavana
Toto bodies are eosinophilic structures that resemble the cells of the superficial cell layer of the oral epithelium. Toto bodies commonly are associated with inflammatory gingival and other mucosal lesions including pyogenic granuloma, irritational fibroma, epulis fissuratum, peripheral giant cell granuloma and inflammatory hyperplastic gingivitis. We evaluated staining characteristics of Toto bodies to establish their origin and to identify their significance in lesions. We investigated pyogenic granuloma, fibroma and leukoplakia with epithelium that exhibited Toto bodies after hematoxylin and eosin (staining...
May 21, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
R A Dennis, K K Garner, P M Kortebein, C M Parkes, M M Bopp, S Li, K P Padala, P R Padala, D H Sullivan
OBJECTIVES: Determine if the muscle mRNA levels of three growth factors (insulin-like growth factor-1 [IGF1], ciliary neurotropic factor [CNTF], and vascular endothelial growth factor-D [VEGFD]) are correlated with muscle size and strength gains from resistance exercise while piloting a training program in older adults taking medications and supplements for age-associated problems. DESIGN: Single-arm prospective study. SETTING: US Veterans Affairs hospital...
2018: Journal of Nutrition, Health & Aging
Soumya Padala, Boon Ching Tee, Frank M Beck, Kathy Elias, Do-Gyoon Kim, Zongyang Sun
OBJECTIVES: To test a proof-of-concept that the accuracy and reliability of alveolar bone height measurements from orthodontic grade (large field-of-view [FOV], large voxel-size) cone-beam computed tomography (CBCT) images may be improved by using pixel gray values. MATERIALS AND METHODS: Twenty fresh cadaver pig heads underwent CBCT scans (17 × 23 cm FOV, 0.4-mm voxel size). Buccal alveolar bone heights of maxillary first molars were measured using the conventional vision-based (VB) and the proposed gray value-assisted (GVA) methods...
March 2018: Angle Orthodontist
Prasad R Padala, Kalpana P Padala, Shelly Y Lensing, Andrea N Jackson, Cassandra R Hunter, Christopher M Parkes, Richard A Dennis, Melinda M Bopp, Ricardo Caceda, Mark S Mennemeier, Paula K Roberson, Dennis H Sullivan
Apathy is a common and disabling behavioral concomitant of many neurodegenerative conditions. The presence of apathy with Mild Cognitive Impairment (MCI) is linked with heightened rates of conversion to Alzheimer's disease. Improving apathy may slow the neurodegenerative process. The objective was to establish the efficacy of repetitive transcranial magnetic stimulation (rTMS) in improving apathy in older adults with MCI. An 8-week, double-blind, randomized, sham-controlled cross-over study was conducted in nine subjects (66 ± 9 years) with apathy and MCI...
March 2018: Psychiatry Research
Surendra K Chawla, Muralidhar Padala, W Randolph Chitwood, Robert W M Frater
OBJECTIVE: We report a new expanded polytetrafluoroethylene multichordal mitral apparatus (MitraPatch) to simplify mitral repairs involving multiple cusps and sought to describe the surgical technique and demonstrate the efficacy of the device. METHODS: MitraPatch was laser cut from a single sheet of expanded polytetrafluoroethylene and mounted on a custom-designed handle. Surgical technique to deploy the apparatus on the native mitral valve was developed in ex vivo porcine hearts...
November 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
Prasad R Padala, Kalpana P Padala, Shelly Y Lensing, Daniel Ramirez, Varun Monga, Melinda M Bopp, Paula K Roberson, Richard A Dennis, Frederick Petty, Dennis H Sullivan, William J Burke
OBJECTIVE: Apathy is a common behavioral problem in Alzheimer's disease. Apathy has profound consequences, such as functional impairment, higher service utilization, higher caregiver burden, and increased mortality. The authors' objective was to study the effects of methylphenidate on apathy in Alzheimer's disease. METHOD: A 12-week, prospective, double-blind, randomized, placebo-controlled trial (methylphenidate versus placebo) was conducted in community-dwelling veterans (N=60) with mild Alzheimer's disease...
February 1, 2018: American Journal of Psychiatry
Ramakrishna Nirogi, Devender Reddy Ajjala, Raghupathi Aleti, Lakshmiprasanna Rayapati, Hanumanth Rao Pantangi, Rajesh Kumar Boggavarapu, Naga Surya Prakash Padala
A sensitive and rapid LC-MS/MS method was developed and validated for the quantification of SUVN-502 and M1 of SUVN-502, a 5-HT6 receptor antagonist for the treatment of dementia associated with Alzheimer's disease. Following solid-phase extraction, SUVN-502 and M1 of SUVN-502 and IS were eluted with 10mM ammonium acetate (pH 4.0) and acetonitrile using a rapid gradient program on reverse phase column. Multiple reaction monitoring mode was used to monitor the respective transitions of m/z 478.2→377.7 for SUVN-502 and m/z 464...
October 25, 2017: Journal of Pharmaceutical and Biomedical Analysis
Kalpana P Padala, Prasad R Padala, Shelly Y Lensing, Richard A Dennis, Melinda M Bopp, Paula K Roberson, Dennis H Sullivan
BACKGROUND/OBJECTIVE: Balance problems are common in older adults with Alzheimer's disease (AD). The objective was to study the effects of a Wii-Fit interactive video-game-led physical exercise program to a walking program on measures of balance in older adults with mild AD. METHODS: A prospective randomized controlled parallel-group trial (Wii-Fit versus walking) was conducted in thirty community-dwelling older adults (73±6.2 years) with mild AD. Home-based exercises were performed under caregiver supervision for 8 weeks...
2017: Journal of Alzheimer's Disease: JAD
Kalpana P Padala, Prasad R Padala, Shelly Y Lensing, Richard A Dennis, Melinda M Bopp, Christopher M Parkes, Mark K Garrison, Patricia M Dubbert, Paula K Roberson, Dennis H Sullivan
Background/Objectives . Balance problems are well-established modifiable risk factors for falls, which are common in older adults. The objective of this study was to establish the efficacy of a Wii-Fit interactive video-game-led physical exercise program to improve balance in older Veterans. Methods . A prospective randomized controlled parallel-group trial was conducted at Veterans Affairs Medical Center. Thirty community dwelling Veterans aged 68 (±6.7) years were randomized to either the exercise or control groups...
2017: Journal of Aging Research
Santosh K Padala, Aditya Saini, Zachary M Gertz, Gordon S Morano, Kenneth A Ellenbogen, Jayanthi N Koneru
No abstract text is available yet for this article.
February 13, 2017: JACC. Cardiovascular Interventions
Krista L Lanctôt, Luis Agüera-Ortiz, Henry Brodaty, Paul T Francis, Yonas E Geda, Zahinoor Ismail, Gad A Marshall, Moyra E Mortby, Chiadi U Onyike, Prasad R Padala, Antonios M Politis, Paul B Rosenberg, Emma Siegel, David L Sultzer, Eleenor H Abraham
INTRODUCTION: Apathy is common in neurocognitive disorders (NCDs) such as Alzheimer's disease and mild cognitive impairment. Although the definition of apathy is inconsistent in the literature, apathy is primarily defined as a loss of motivation and decreased interest in daily activities. METHODS: The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) Neuropsychiatric Syndromes Professional Interest Area (NPS-PIA) Apathy workgroup reviewed the latest research regarding apathy in NCDs...
January 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Surendra K Chawla, Weiwei Shi, Bryant V McIver, Jakob Vinten-Johansen, Robert W M Frater, Muralidhar Padala
Surgical repair of flail mitral valve leaflets with neochordoplasty has good outcomes, but implementing it in anterior and bi-leaflet leaflet repair is challenging. Placing and sizing individual neochordae is time consuming and error prone, with persistent localized flail if performed incorrectly. In this study, we report our pre-clinical experience with a novel multi-chordal patch for mitral valve repair. The device was designed based on human cadaver hearts, and laser cut from expanded polytetrafluoroethylene...
April 2016: Journal of Cardiovascular Translational Research
Santosh K Padala, Mandeep S Sidhu, Jeremiah R Brown, Jonathan S Zipursky, David A Steckman, Dhaval R Parikh, Mark L Greenberg
AIMS: The electrocardiographic (ECG) signs used to differentiate ventricular tachycardia (VT) from supraventricular tachycardia (SVT) with aberrancy are specific but not highly sensitive. The purpose of this study was to define the utility of an underappreciated form of atrioventricular (AV) dissociation at the onset of tachycardia, a single dissociated P wave, in the differentiation of non-sustained monomorphic wide complex tachycardia (WCT) in hospitalized patients. METHODS AND RESULTS: We prospectively analysed tracings from 102 consecutive hospitalized patients who had an episode of non-sustained (≥5 beats, <30 s), monomorphic, WCT (≥100 b...
July 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Santosh K Padala, Mandeep S Sidhu, Pamela M Hartigan, David J Maron, Koon K Teo, John A Spertus, G B John Mancini, Steven P Sedlis, Bernard R Chaitman, Gary V Heller, William S Weintraub, William E Boden
The impact of baseline exercise capacity on clinical outcomes in patients with stable ischemic heart disease randomized to an initial strategy of optimal medical therapy (OMT) with or without percutaneous coronary intervention (PCI) in the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial has not been studied. A post hoc analysis was performed in 1,052 patients of COURAGE (PCI + OMT: n = 527, OMT: n = 525) who underwent exercise treadmill testing at baseline. Patients were categorized into 2 exercise capacity groups based on metabolic equivalents (METs) achieved during baseline exercise treadmill testing (<7 METs: n = 464, ≥7 METs: n = 588) and were followed for a median of 4...
November 15, 2015: American Journal of Cardiology
Richard A Dennis, Usha Ponnappan, Ralph L Kodell, Kimberly K Garner, Christopher M Parkes, Melinda M Bopp, Kalpana P Padala, Charlotte A Peterson, Prasad R Padala, Dennis H Sullivan
BACKGROUND: Immune function may influence the ability of older adults to maintain or improve muscle mass, strength, and function during aging. Thus, nutritional supplementation that supports the immune system could complement resistance exercise as an intervention for age-associated muscle loss. The current study will determine the relationship between immune function and exercise training outcomes for older adults who consume a nutritional supplement or placebo during resistance training and post-training follow-up...
March 27, 2015: Trials
Santhoshi Rani Nanchari, Anuradha Cingeetham, Phannibhushann Meka, Surekha Damineni, Nageshwarao Tipirisetti, Chiranjeevi Padala, Sandhya Annamaneni, Surekha Rani Hanumanth, Raghunadha Rao Digumarthi, Vishnupriya Satti
Rrp1B (ribosomal RNA processing1 homolog B) is a novel candidate metastasis modifier gene in breast cancer. Functional gene assays demonstrated that a physical and functional interaction existing between Rrp1b and metastasis modifier gene SIPA1 causes reduction in the tumor growth and metastatic potential. Ectopic expression of Rrp1B modulates various metastasis predictive extra cellular matrix (ECM) genes associated with tumor suppression. The aim of this study is to determine the functional significance of single nucleotide polymorphism (SNP) in human Rrp1B gene (1307 T>C; rs9306160) with breast cancer development and progression...
February 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Santosh K Padala, Abhijit Ghatak, Sandeep Padala, Deborah M Katten, Donna M Polk, Gary V Heller
BACKGROUND: Previous studies have demonstrated that diabetic patients undergoing exercise stress single-photon emission-computed tomography (SPECT) myocardial perfusion imaging (MPI) have significantly lower cardiac events when compared to the diabetic patients undergoing pharmacologic stress SPECT MPI across all perfusion categories. However, there are limited data on the level of exercise achieved during exercise SPECT MPI among diabetic patients and its impact on cardiovascular outcomes...
December 2014: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Michele Miragoli, Magdi H Yacoub, Ismail El-Hamamsy, Jose L Sanchez-Alonso, Alexey Moshkov, Napachanok Mongkoldhumrongkul, Muralindar Padala, Saravanan Paramagurunathan, Padmini Sarathchandra, Yuri E Korchev, Julia Gorelik, Adrian H Chester
Aortic valve endothelial cells (ECs) function in vastly different levels of shear stress. The biomechanical characteristics of cells on each side of valve have not been investigated. We assessed the morphology and mechanical properties of cultured or native valve ECs on intact porcine aortic valve cusps using a scanning ion conductance microscope (SICM). The autocrine influence of several endothelial-derived mediators on cell compliance and the expression of actin were also examined. Cells on the aortic side of the valve are characterized by a more elongated shape and were aligned along a single axis...
July 1, 2014: American Journal of Physiology. Heart and Circulatory Physiology
Vinod H Thourani, Rebecca L Gunter, Stuart Hurst, Patrick Kilgo, Murali Padala, John D Puskas, Omar M Lattouf, Michael E Halkos, Robert A Guyton
BACKGROUND AND AIM OF THE STUDY: Short-term postoperative warfarin therapy has been used to decrease neurologic events following mitral valve repair or bioprosthetic replacement (MVR). The study aim was to compare the short- and long-term outcomes of patients undergoing mitral valve surgery with or without short-term postoperative warfarin. METHODS: A single academic US institution retrospective review was performed on discharged patients who underwent MVR between January 1996 and March 2010...
September 2013: Journal of Heart Valve Disease
Abhijit Ghatak, Santosh Padala, Deborah M Katten, Donna M Polk, Gary V Heller
BACKGROUND: Previous studies have suggested that diabetic patients undergoing single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) are at greater risk for cardiac events than non-diabetic patients with both normal and abnormal imaging results. However, the impact of stress modality on outcomes in this patient group has not been examined. METHODS: The data on all patients undergoing exercise stress or vasodilator stress SPECT MPI from 1996 to 2005 were reviewed...
August 2013: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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