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https://www.readbyqxmd.com/read/28103726/antibacterial-activities-of-chemical-constituents-from-the-aerial-parts-of-hedyotis-pilulifera
#1
Hoai Thi Nguyen, Duc Viet Ho, Hung Quoc Vo, Anh Tuan Le, Hien Minh Nguyen, Takeshi Kodama, Takuya Ito, Hiroyuki Morita, Ain Raal
CONTEXT: Hedyotis pilulifera (Pit.) T.N. Ninh (Rubiaceae) has been used in Vietnamese ethnomedicine; the methanol extract exhibited antibacterial activity in our preliminary screening. OBJECTIVES: In this study, compounds from H. pilulifera were isolated and their antibacterial activity in vitro was evaluated. MATERIALS AND METHODS: The aerial parts of H. pilulifera (1.4 kg) were extracted with MeOH, suspended in water and ethyl acetate extract was chromatographed on a silica gel column...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28093997/sonication-assisted-nanoprecipitation-in-drug-delivery
#2
Anh Thi Ngoc Vo, Thinh Duc Luu, Minh Ngoc Uyen Nguyen, Toi Van Vo, Wei Duan, Phuong Ha-Lien Tran, Thao Truong-Dinh Tran
Sonication-assisted nanoprecipitation provides an effective tool for nanomedicine engineering in therapeutic improvement. In the scope of this review, original works in interdisciplinary areas of using sonication with precipitation method for nanoparticulate drug delivery systems and its applications in management of different diseases are discussed. The use of sonication-assisted nanoprecipitation has been proved to improve drug bioavailability, which attracts tremendous interests as an effective strategy for drug delivery...
January 15, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28067667/excessive-expression-of-mir-27-impairs-treg-mediated-immunological-tolerance
#3
Leilani O Cruz, Somaye Sadat Hashemifar, Cheng-Jang Wu, Sunglim Cho, Duc T Nguyen, Ling-Li Lin, Aly Azeem Khan, Li-Fan Lu
MicroRNAs (miRs) are tightly regulated in the immune system, and aberrant expression of miRs often results in hematopoietic malignancies and autoimmune diseases. Previously, it was suggested that elevated levels of miR-27 in T cells isolated from patients with multiple sclerosis facilitate disease progression by inhibiting Th2 immunity and promoting pathogenic Th1 responses. Here we have demonstrated that, although mice with T cell-specific overexpression of miR-27 harbor dysregulated Th1 responses and develop autoimmune pathology, these disease phenotypes are not driven by miR-27 in effector T cells in a cell-autonomous manner...
January 9, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28059106/the-effect-of-electronic-structure-on-the-phases-present-in-high-entropy-alloys
#4
Zhaoyuan Leong, Jan S Wróbel, Sergei L Dudarev, Russell Goodall, Iain Todd, Duc Nguyen-Manh
Multicomponent systems, termed High Entropy Alloys (HEAs), with predominantly single solid solution phases are a current area of focus in alloy development. Although different empirical rules have been introduced to understand phase formation and determine what the dominant phases may be in these systems, experimental investigation has revealed that in many cases their structure is not a single solid solution phase, and that the rules may not accurately distinguish the stability of the phase boundaries. Here, a combined modelling and experimental approach that looks into the electronic structure is proposed to improve accuracy of the predictions of the majority phase...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28052785/detection-reporting-and-treatment-of-hepatitis-c-infections-among-hemodialysis-patients
#5
Melissa G Collier, Duc B Nguyen, Priti R Patel, Anne C Moorman
No abstract text is available yet for this article.
January 5, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28038832/lignan-derivatives-from-selaginella-tamariscina-and-their-nitric-oxide-inhibitory-effects-in-lps-stimulated-raw-264-7-cells
#6
Le Duc Dat, Bing Tian Zhao, Nguyen Duc Hung, Jeong Hyung Lee, Byung Sun Min, Mi Hee Woo
The chemical characterization of Selaginella tamariscina leaves resulted in the isolation of five lignanoside derivatives (1-4 and 6) and one neolignan (5). These compounds include three new lignanosides, tamariscinosides D-F (1-3), and one liriodendrin (4) that were isolated for the first time from this plant, together with two known compounds, (2R,3S)-dihydro-2-(3,5-dimethoxy-4-hydroxyphenyl)-7-methoxy-5-acetyl-benzofuran (5) and moellenoside B (6). The chemical structures of these isolated compounds were determined using 1D and 2D NMR, MS, and CD spectroscopic data, and the results were compared to data previously reported in the literatures...
December 9, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28035554/a-new-saponin-from-acanthopanax-koreanum-with-anti-inflammatory-activity
#7
Le Duc Dat, Nguyen Phuong Thao, Bui Thi Thuy Luyen, Bui Huu Tai, Mi Hee Woo, Zahid Manzoor, Irshad Ali, Young Sang Koh, Young Ho Kim
Twelve saponins were isolated from the leaves of Acanthopanax koreanum, including one new lupane-type triterpene glycoside, named acankoreoside R (1), together with 11 known triterpenoid saponins (2-12). Their structures were elucidated by 1D and 2D nuclear magnetic resonance (NMR), mass spectroscopic data (MS). All of the fractions and isolated saponins were evaluated for anti-inflammatory activities in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs) by ELISA. Among them, compounds 1-5, 7, 10, and 12 showed strong inhibitions towards interleukin-12 (IL-12) production with IC50 values ranging from 1...
December 29, 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28035078/recent-progress-in-understanding-the-conformational-mechanism-of-heterotrimeric-g-protein-activation
#8
REVIEW
Nguyen Minh Duc, Hee Ryung Kim, Ka Young Chung
Heterotrimeric G proteins are key intracellular coordinators that receive signals from cells through activation of cognate G protein-coupled receptors (GPCRs). The details of their atomic interactions and structural mechanisms have been described by many biochemical and biophysical studies. Specifically, a framework for understanding conformational changes in the receptor upon ligand binding and associated G protein activation was provided by description of the crystal structure of the β2-adrenoceptor-Gs complex in 2011...
January 1, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28028916/enhancing-the-luminescence-of-eu-3-eu-2-ion-doped-hydroxyapatite-by-fluoridation-and-thermal-annealing
#9
Hoang Nhu Van, Phuong Dinh Tam, Nguyen Duc Trung Kien, Pham Thanh Huy, Vuong-Hung Pham
This paper reports a novel way for the synthesis of a europium (Eu)-doped fluor-hydroxyapatite (FHA) nanostructure to control the luminescence of hydroxyapatite nanophosphor, particularly, by applying optimum fluorine concentrations, annealed temperatures and pH value. The Eu-doped FHA was made using the co-precipitation method followed by thermal annealing in air and reducing in a H2 atmosphere to control the visible light emission center of the nanophosphors. The intensities of the OH(-) group decreased with the increasing fluorine concentrations...
December 28, 2016: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28009478/local-effects-on-airway-inflammation-and-systemic-uptake-of-5-nm-pegylated-and-citrated-gold-nanoparticles-in-asthmatic-mice
#10
Albert J Omlor, Duc D Le, Janine Schlicker, Matthias Hannig, Raphael Ewen, Sebastian Heck, Christian Herr, Annette Kraegeloh, Christina Hein, Ralf Kautenburger, Guido Kickelbick, Robert Bals, Juliane Nguyen, Q Thai Dinh
Nanotechnology is showing promise in many medical applications such as drug delivery and hyperthermia. Nanoparticles administered to the respiratory tract cause local reactions and cross the blood-air barrier, thereby providing a means for easy systemic administration but also a potential source of toxicity. Little is known about how these effects are influenced by preexisting airway diseases such as asthma. Here, BALB/c mice are treated according to the ovalbumin (OVA) asthma protocol to promote allergic airway inflammation...
December 23, 2016: Small
https://www.readbyqxmd.com/read/28006013/procarcinogens-determination-and-evaluation-by-yeast-based-biosensor-transformed-with-plasmids-incorporating-rad54-reporter-construct-and-cytochrome-p450-genes
#11
Van Ngoc Bui, Thi Thu Huyen Nguyen, Chi Thanh Mai, Yvan Bettarel, Thi Yen Hoang, Thi Thuy Linh Trinh, Nam Hai Truong, Hoang Ha Chu, Vu Thanh Thanh Nguyen, Huu Duc Nguyen, Stefan Wölfl
In Vietnam, a great number of toxic substances, including carcinogens and procarcinogens, from industrial and agricultural activities, food production, and healthcare services are daily released into the environment. In the present study, we report the development of novel yeast-based biosensor systems to determine both genotoxic carcinogens and procarcinogens by cotransformation with two plasmids. One plasmid is carrying human CPR and CYP (CYP3A4, CYP2B6, or CYP2D6) genes, while the other contains the RAD54-GFP reporter construct...
2016: PloS One
https://www.readbyqxmd.com/read/28004051/replica-exchange-molecular-dynamics-study-of-the-truncated-amyloid-beta-11-40-trimer-in-solution
#12
Son Tung Ngo, Huynh Minh Hung, Duc Toan Truong, Minh Tho Nguyen
Amyloid beta (Aβ) oligomers are neurotoxic compounds that destroy the brain of Alzheimer's disease patients. Recent studies indicated that the trimer is one of the most cytotoxic forms of low molecular weight Aβ oligomers. As there was limited information about the structure of the Aβ trimer, either by experiment or by computation, we determined in this work the structure of the 3Aβ11-40 oligomer for the first time using the temperature replica exchange molecular dynamics simulations in the presence of an explicit solvent...
January 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27989508/a-multi-network-approach-identifies-protein-specific-co-expression-in-asymptomatic-and-symptomatic-alzheimer-s-disease
#13
Nicholas T Seyfried, Eric B Dammer, Vivek Swarup, Divya Nandakumar, Duc M Duong, Luming Yin, Qiudong Deng, Tram Nguyen, Chadwick M Hales, Thomas Wingo, Jonathan Glass, Marla Gearing, Madhav Thambisetty, Juan C Troncoso, Daniel H Geschwind, James J Lah, Allan I Levey
Here, we report proteomic analyses of 129 human cortical tissues to define changes associated with the asymptomatic and symptomatic stages of Alzheimer's disease (AD). Network analysis revealed 16 modules of co-expressed proteins, 10 of which correlated with AD phenotypes. A subset of modules overlapped with RNA co-expression networks, including those associated with neurons and astroglial cell types, showing altered expression in AD, even in the asymptomatic stages. Overlap of RNA and protein networks was otherwise modest, with many modules specific to the proteome, including those linked to microtubule function and inflammation...
December 14, 2016: Cell Systems
https://www.readbyqxmd.com/read/27973483/precise-optical-surface-profilometry-using-innovative-chromatic-differential-confocal-microscopy
#14
Liang-Chia Chen, Duc Trung Nguyen, Yi-Wei Chang
A broadband differential confocal method that exploits novel double-slit chromatic confocal microscopy was developed for one-shot microscopic 3D surface measurement. In situ automated optical inspection to generate microscopic surface profiles has become extremely important for ensuring strict geometric compliance in precision manufacturing. An innovative optical configuration was developed to generate a pair of orthogonally polarized incident light beams, and a pair of the conjugate light beams was detected using two slits of different widths at the corresponding conjugate imaging locations of the incident beams...
December 15, 2016: Optics Letters
https://www.readbyqxmd.com/read/27940061/hemodialyzer-reuse-and-gram-negative-bloodstream-infections
#15
Chris Edens, Jacklyn Wong, Meghan Lyman, Kyle Rizzo, Duc Nguyen, Michela Blain, Sam Horwich-Scholefield, Heather Moulton-Meissner, Erin Epson, Jon Rosenberg, Priti R Patel
BACKGROUND: Clusters of bloodstream infections caused by Burkholderia cepacia and Stenotrophomonas maltophilia are uncommon, but have been previously identified in hemodialysis centers that reprocessed dialyzers for reuse on patients. We investigated an outbreak of bloodstream infections caused by B cepacia and S maltophilia among hemodialysis patients in clinics of a dialysis organization. STUDY DESIGN: Outbreak investigation, including matched case-control study...
December 7, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27893861/attitudes-towards-intimate-partner-violence-against-women-among-women-and-men-in-39-low-and-middle-income-countries
#16
Thach Duc Tran, Hau Nguyen, Jane Fisher
BACKGROUND: Violence against women perpetrated by an intimate partner (IPV) is prevalent in low- and middle-income countries (LAMIC). The aim was to describe the attitudes of women and men towards perpetration of physical violence to women by an intimate partner, in a large group of low- and middle-income countries. METHODS AND FINDINGS: We used data from Round Four of the UNICEF Multiple Indicator Cluster Surveys. Attitudes towards IPV against women were assessed by a study-specific scale asking if 'wife beating' is justified in any of five circumstances...
2016: PloS One
https://www.readbyqxmd.com/read/27889684/human-milk-oligosaccharide-effects-on-intestinal-function-and-inflammation-after-preterm-birth-in-pigs
#17
Stine O Rasmussen, Lena Martin, Mette V Østergaard, Silvia Rudloff, Michael Roggenbuck, Duc Ninh Nguyen, Per T Sangild, Stine B Bering
: Human milk oligosaccharides (HMOs) may mediate prebiotic and anti-inflammatory effects in newborns. This is particularly important for preterm infants who are highly susceptible to intestinal dysfunction and necrotizing enterocolitis (NEC). We hypothesized that HMO supplementation of infant formula (IF) improves intestinal function, bacterial colonization and NEC resistance immediately after preterm birth, as tested in a preterm pig model. Mixtures of HMOs were investigated in intestinal epithelial cells and in preterm pigs (n=112) fed IF supplemented without (CON) or with a mixture of four HMOs (4-HMO) or >25 HMOs (25-HMO, 5-10 g/L given for 5 or 11 days)...
November 4, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27887578/evaluation-of-an-international-educational-programme-for-health-care-professionals-on-best-practice-in-the-management-of-a-perinatal-death-improving-perinatal-mortality-review-and-outcomes-via-education-improve
#18
Paul A Gardiner, Alison L Kent, Viviana Rodriguez, Aleena M Wojcieszek, David Ellwood, Adrienne Gordon, Patricia A Wilson, Diana M Bond, Adrian Charles, Susan Arbuckle, Glenn J Gardener, Jeremy J Oats, Jan Jaap Erwich, Fleurisca J Korteweg, T H Nguyen Duc, Susannah Hopkins Leisher, Kamal Kishore, Robert M Silver, Alexander E Heazell, Claire Storey, Vicki Flenady
BACKGROUND: Stillbirths and neonatal deaths are devastating events for both parents and clinicians and are global public health concerns. Careful clinical management after these deaths is required, including appropriate investigation and assessment to determine cause (s) to prevent future losses, and to improve bereavement care for families. An educational programme for health care professionals working in maternal and child health has been designed to address these needs according to the Perinatal Society of Australia and New Zealand Guideline for Perinatal Mortality: IMproving Perinatal mortality Review and Outcomes Via Education (IMPROVE)...
November 25, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27878546/investigation-of-antibiotics-in-health-care-wastewater-in-ho-chi-minh-city-vietnam
#19
Thi-Dieu-Hien Vo, Xuan-Thanh Bui, Ngoc-Dan-Thanh Cao, Vinh-Phuc Luu, Thanh-Tin Nguyen, Bao-Trong Dang, Minh-Quan Thai, Dinh-Duc Nguyen, Thanh-Son Nguyen, Quoc-Tuc Dinh, Thanh-Son Dao
Hospital wastewater contains huge amounts of hazardous pollutants which are being discharged daily to environment with or without treatment. Antibiotics were among the important group of pharmaceuticals considered as a potential source of health risk for human and other living creatures. Although the investigations about the existence of antibiotics in hospital wastewater have gained concern for researchers in many countries, there is only one research conducted in Hanoi-Vietnam. Hence, in this study, investigations have been done to fulfill the requirement of real situation in Vietnam by accomplishing survey for 39 health care facilities in Ho Chi Minh City...
December 2016: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27877174/dna-methyltransferase-inhibitor-promotes-human-cd4-cd25-h-foxp3-regulatory-t-lymphocyte-induction-under-suboptimal-tcr-stimulation
#20
Chun-Hao Lu, Cheng-Jang Wu, Cheng-Chi Chan, Duc T Nguyen, Kuo-Ray Lin, Syh-Jae Lin, Li-Chen Chen, Jeffrey Jong-Yong Yen, Ming-Ling Kuo
The "master transcription factor" FOXP3 regulates the differentiation, homeostasis, and suppressor function of CD4(+) regulatory T (Treg) cells, which are critical in maintaining immune tolerance. Epigenetic regulation of FOXP3 expression has been demonstrated to be important to Treg cell development, but the induction of human Treg cells through epigenetic modification has not been clearly described. We report that the combination of the DNA methyltransferase inhibitor 5-azacytidine (5-Aza) and suboptimal T cell receptor (TCR) stimulation promoted CD4(+)CD25(h)FOXP3(+) T cell induction from human CD4(+)CD25(-) T cells...
2016: Frontiers in Immunology
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