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Duc Nguyen

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https://www.readbyqxmd.com/read/28531236/psychosine-enhances-the-shedding-of-membrane-microvesicles-implications-in-demyelination-in-krabbe-s-disease
#1
Ludovic D'Auria, Cory Reiter, Emma Ward, Ana Lis Moyano, Michael S Marshall, Duc Nguyen, Giuseppe Scesa, Zane Hauck, Richard van Breemen, Maria I Givogri, Ernesto R Bongarzone
In prior studies, our laboratory showed that psychosine accumulates and disrupts lipid rafts in brain membranes of Krabbe's disease. A model of lipid raft disruption helped explaining psychosine's effects on several signaling pathways important for oligodendrocyte survival and differentiation but provided more limited insight in how this sphingolipid caused demyelination. Here, we have studied how this cationic inverted coned lipid affects the fluidity, stability and structure of myelin and plasma membranes...
2017: PloS One
https://www.readbyqxmd.com/read/28526733/discovery-and-optimization-of-hkt288-a-cadherin-6-targeting-adc-for-the-treatment-of-ovarian-and-renal-cancer
#2
Carl U Bialucha, Scott D Collins, Xiao Li, Parmita Saxena, Xiamei Zhang, Clemens Dürr, Bruno LaFont, Pierric Prieur, Yeonju Shim, Rebecca Mosher, David Lee, Lance Ostrom, Tiancen Hu, Sanela Bilic, Ivana Liric Rajlic, Vladimir Capka, Wei Jiang, Joel P Wagner, GiNell Elliott, Artur Veloso, Jessica C Piel, Meghan M Flaherty, Keith G Mansfield, Emily K Meseck, Tina Rubic-Schneider, Anne Serdakowski London, William R Tschantz, Markus Kurz, Duc Nguyen, Aaron Bourret, Matthew J Meyer, Jason E Faris, Mary J Janatpour, Vivien W Chan, Nicholas C Yoder, Kalli C Catcott, Molly A McShea, Xiuxia Sun, Hui Gao, Juliet Williams, Francesco Hofmann, Jeffrey A Engelman, Seth A Ettenberg, William R Sellers, Emma Lees
Despite an improving therapeutic landscape, significant challenges remain in treating the majority of advanced ovarian and renal cancer patients. We identified the cell-cell adhesion molecule cadherin-6 (CDH6) as a lineage gene having significant differential expression in ovarian and kidney cancer. HKT288 is an optimized CDH6-targeting DM4-based antibody drug conjugate (ADC) developed for the treatment of these diseases. Our study provides mechanistic evidence supporting the importance of linker choice for optimal anti-tumor activity and highlights CDH6 as a novel antigen for biotherapeutic development...
May 19, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28525955/imaging-and-manipulating-energy-transfer-among-quantum-dots-at-individual-dot-resolution
#3
Duc A Nguyen, Huy A Nguyen, Joseph W Lyding, Martin Gruebele
Many processes of interest in quantum dots involve charge or energy transfer from one dot to another. Energy transfer in films of quantum dots as well as between linked quantum dots has been demonstrated by luminescence shift, and the ultrafast time-dependence of energy transfer processes has been resolved. Bandgap variation among dots (energy disorder) and dot separation are known to play an important role in how energy diffuses. Thus it would be very useful if energy transfer could be visualized directly on a dot-by-dot basis among small clusters or within films of quantum dots...
May 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28523209/using-online-respondent-driven-sampling-for-vietnamese-youths-alcohol-use-and-associated-risk-factors
#4
Melvyn W B Zhang, Bach Xuan Tran, Huong Lan Thi Nguyen, Huong Thi Le, Nguyen Hoang Long, Huong Thi Le, Nguyen Duc Hinh, Tran Dinh Tho, Bao Nguyen Le, Vu Thi Minh Thuc, Chau Ngo, Nguyen Huu Tu, Carl A Latkin, Roger Cm Ho
OBJECTIVES: The average alcohol consumption per capita among Vietnamese adults has consistently increased. Although alcohol-related disorders have been extensively studied, there is a paucity of research shedding light on this issue among Internet users. The study aimed to examine the severity of alcohol-related disorders and other associated factors that might predispose individuals towards alcohol usage in a sample of youths recruited online. METHODS: An online cross-sectional study was conducted with 1,080 Vietnamese youths...
April 2017: Healthcare Informatics Research
https://www.readbyqxmd.com/read/28515634/difference-in-quality-of-life-and-associated-factors-among-the-elderly-in-rural-vietnam
#5
REVIEW
T Van Nguyen, H Van Nguyen, T Duc Nguyen, T Van Nguyen, T The Nguyen
BACKGROUND: In Vietnam today, many generations remain living together in a family. With escalating urbanization and population aging, mental health disorders and the quality of life (QoL) among the elderly are gradually presenting themselves as of great concern. The objective of this study was to examine gender differences in QoL and some associated factors among the elderly in rural Vietnam using the QoL scale of WHO (WHOQOL-BREF). METHODS: A cross-sectional study using quantitative methods...
March 2017: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/28499190/ellagitannin-and-flavonoid-constituents-from-agrimonia-pilosa-ledeb-with-their-protein-tyrosine-phosphatase-and-acetylcholinesterase-inhibitory-activities
#6
Duc Hung Nguyen, U Min Seo, Bing Tian Zhao, Duc Dat Le, Su Hui Seong, Jae Sue Choi, Byung Sun Min, Mi Hee Woo
A new ellagitannin, agritannin (1), a new flavone glycoside, agriflavone (2), and another flavone glycoside with spectroscopic data reported for the first time, kaempferol-3-O-[(S)-3-hydroxy-3-methylglutaryl (1→6)]-β-d-glucoside (3), along with 16 known compounds were isolated from the aerial parts of Agrimonia pilosa Ledeb. These compounds were evaluated for PTP1B inhibitory activity. Among them, compounds 9 and 18 displayed potential inhibitory activity against PTP1B with IC50 values of 7.14±1.75 and 7...
April 30, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28499188/ptp1b-inhibitors-from-selaginella-tamariscina-beauv-spring-and-their-kinetic-properties-and-molecular-docking-simulation
#7
Duc Dat Le, Duc Hung Nguyen, Bing Tian Zhao, Su Hui Seong, Jae Sue Choi, Seok Kyu Kim, Jeong Ah Kim, Byung Sun Min, Mi Hee Woo
Diabetes is one of the most popular worldwide diseases, regulated by the defects in insulin secretion, insulin action, or both. The overexpression of protein tyrosine phosphatase 1B (PTP1B) was found to down-regulate the insulin-receptor activation. PTP1B has been known as a strategy for the treatment of diabetes via the regulation of insulin signal transduction pathway. Herein, we investigated the PTP1B inhibitors isolated from natural sources. The chemical investigation of Selaginella tamariscina (Beauv.) Spring revealed seven unsaturated alkynyl phenols 1-7, four new selaginellins T-W 1-4 together with three known compounds 5-7 isolated from the aerial parts...
May 2, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28497589/the-asia-pacific-colorectal-screening-score-is-useful-to-stratify-risk-for-colorectal-advanced-neoplasms-in-vietnamese-patients-with-irritable-bowel-syndrome
#8
Duc Trong Quach, Toru Hiyama, Thu Anh Nguyen, Hoa Quoc Ly, Shinji Tanaka
BACKGROUND: The Asia Pacific Colorectal Screening (APCS) score has been validated in several populations but not yet in patients with irritable bowel syndrome (IBS). AIM: To assess the performance of APCS score in stratifying risk of colorectal advanced neoplasms (CAN) in Vietnamese IBS patients. METHODS: Consecutive patients who fulfilled IBS diagnosis criteria according to the Rome III were prospectively enrolled and underwent colonoscopy...
May 11, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28492971/current-conservation-status-of-germain-s-langur-trachypithecus-germaini-in-vietnam
#9
Bang Van Tran, Minh Anh Nguyen, Dat Quoc Nguyen, Quan Bich Thi Truong, Andie Ang, Herbert H Covert, Duc Minh Hoang
Following the split of the silvered langurs of Indochina into two species based on molecular and phenotypic data, there is a need to reevaluate their distribution and update their conservation status. Here, we report the distribution and assess the population size of Germain's langur (Trachypithecus germaini) within its known range across Vietnam. We confirmed this species at six of seven survey sites in different habitats within three provinces in the Mekong Delta Region, including semi-evergreen forest at the Seven Mountains of An Giang Province, mangrove forest in Ngoc Hien and Nam Can Districts and Melaleuca forest in U Minh Ha National Park of Ca Mau Province, and limestone forest at Kien Luong Karst Area and semi-evergreen and evergreen forests at Phu Quoc National Park of Kien Giang Province...
May 10, 2017: Primates; Journal of Primatology
https://www.readbyqxmd.com/read/28487850/willingness-to-pay-for-social-health-insurance-in-central-vietnam
#10
Lan Hoang Nguyen, Anh Thuan Duc Hoang
BACKGROUND: A social health insurance (SHI) program was implemented in Vietnam in 1992. Participation is compulsory for some groups, such as formal-sector workers and voluntary for other groups. In 2013, 68% of the total population was covered by SHI, with most enrollees from compulsory groups. Enrollment has remained low among persons whose enrollment is voluntary. As a result, households face financial risk due to high out-of-pocket payments for health care. The goal of this study is to identify willingness to pay (WTP) for the SHI scheme among persons whose enrollment is voluntary and to examine factors that influence their choice...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28486409/direct-laser-writing-of-magneto-photonic-sub-microstructures-for-prospective-applications-in-biomedical-engineering
#11
Thi Huong Au, Duc Thien Trinh, Quang Cong Tong, Danh Bich Do, Dang Phu Nguyen, Manh-Huong Phan, Ngoc Diep Lai
We report on the fabrication of desired magneto-photonic devices by a low one-photon absorption (LOPA) direct laser writing (DLW) technique on a photocurable nanocomposite consisting of magnetite ( Fe 3 O 4 ) nanoparticles and a commercial SU-8 photoresist. The magnetic nanocomposite was synthesized by mixing Fe 3 O 4 nanoparticles with different kinds of SU-8 photoresists. We demonstrated that the degree of dispersion of Fe 3 O 4 nanoparticles in the nanocomposite depended on the concentration of Fe 3 O 4 nanoparticles, the viscosity of SU-8 resist, and the mixing time...
May 9, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28475117/a-label-free-quantitative-fecal-hemoglobin-detection-platform-for-colorectal-cancer-screening
#12
Gita V Soraya, Thanh C Nguyen, Chathurika D Abeyrathne, Duc H Huynh, Jianxiong Chan, Phuong D Nguyen, Babak Nasr, Gursharan Chana, Patrick Kwan, Efstratios Skafidas
The early detection of colorectal cancer is vital for disease management and patient survival. Fecal hemoglobin detection is a widely-adopted method for screening and early diagnosis. Fecal Immunochemical Test (FIT) is favored over the older generation chemical based Fecal Occult Blood Test (FOBT) as it does not require dietary or drug restrictions, and is specific to human blood from the lower digestive tract. To date, no quantitative FIT platforms are available for use in the point-of-care setting. Here, we report proof of principle data of a novel low cost quantitative fecal immunochemical-based biosensor platform that may be further developed into a point-of-care test in low-resource settings...
May 5, 2017: Biosensors
https://www.readbyqxmd.com/read/28473924/culturally-adaptive-storytelling-intervention-versus-didactic-intervention-to-improve-hypertension-control-in-vietnam-a-cluster-randomized-controlled-feasibility-trial
#13
Hoa L Nguyen, Jeroan J Allison, Duc A Ha, Germán Chiriboga, Ha N Ly, Hanh T Tran, Cuong K Nguyen, Diem M Dang, Ngoc T Phan, Nguyen C Vu, Quang P Nguyen, Robert J Goldberg
BACKGROUND: Vietnam is experiencing an epidemiologic transition with an increased prevalence of non-communicable diseases. Novel, large-scale, effective, and sustainable interventions to control hypertension in Vietnam are needed. We report the results of a cluster-randomized feasibility trial at 3 months follow-up conducted in Hung Yen province, Vietnam, designed to evaluate the feasibility and acceptability of two community-based interventions to improve hypertension control: a "storytelling" intervention, "We Talk about Our Hypertension," and a didactic intervention...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28472255/clinical-outcomes-of-patients-with-drug-resistant-tuberculous-meningitis-treated-with-an-intensified-antituberculosis-regimen
#14
A Dorothee Heemskerk, Mai Thi Hoang Nguyen, Ha Thi Minh Dang, Chau Van Vinh Nguyen, Lan Huu Nguyen, Thu Dang Anh Do, Thuong Thuy Thuong Nguyen, Marcel Wolbers, Jeremy Day, Thao Thi Phuong Le, Bang Duc Nguyen, Maxine Caws, Guy E Thwaites
Background.: Drug-resistant tuberculous meningitis (TBM) is difficult to diagnose and treat. Mortality is high and optimal treatment is unknown. We compared clinical outcomes of drug-resistant and -susceptible TBM treated with either standard or intensified antituberculosis treatment. Methods.: We analyzed the influence of Mycobacterium tuberculosis drug resistance on the outcomes of patients with TBM enrolled into a randomized controlled trial comparing a standard, 9-month antituberculosis regimen (containing rifampicin 10 mg/kg/day) with an intensified regimen with higher-dose rifampicin (15 mg/kg/day) and levofloxacin (20 mg/kg/day) for the first 8 weeks...
May 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28466303/a-new-and-efficient-approach-for-construction-of-uridine-uracil-auxotrophic-mutants-in-the-filamentous-fungus-aspergillus-oryzae-using-agrobacterium-tumefaciens-mediated-transformation
#15
Khuyen Thi Nguyen, Quynh Ngoc Ho, Loc Thi Binh Xuan Do, Linh Thi Dam Mai, Duc-Ngoc Pham, Huyen Thi Thanh Tran, Diep Hong Le, Huy Quang Nguyen, Van-Tuan Tran
Aspergillus oryzae is a filamentous fungus widely used in food industry and as a microbial cell factory for recombinant protein production. Due to the inherent resistance of A. oryzae to common antifungal compounds, genetic transformation of this mold usually requires auxotrophic mutants. In this study, we show that Agrobacterium tumefaciens-mediated transformation (ATMT) method is very efficient for deletion of the pyrG gene in different Aspergillus oryzae wild-type strains to generate uridine/uracil auxotrophic mutants...
June 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28458272/high-prevalence-of-cattle-fascioliasis-in-coastal-areas-of-thua-thien-hue-province-vietnam
#16
Nga Thi Nguyen, Thinh Cong LE, Minh Duc Co Vo, Hoang Van Cao, Ly Thi Nguyen, Khanh Thi Ho, Quyet Ngoc Nguyen, Vui Quang Tran, Yasunobu Matsumoto
In Vietnam, especially central Vietnam, patients with fascioliasis are increasingly being reported. Since the fascioliasis is zoonotic, survey on the cattle fascioliasis should be informative for the control of human fascioliasis. In this study, the prevalence of cattle fascioliasis as well as the density of the intermediate host snails, Lymnaea swinhoei and L. viridis, were studied in Thua Thien Hue (TTH) province during 2014-2015. A total of 572 cattle feces were examined from 27 communes in 9 districts. Fasciola eggs were detected in cattle from 24 communes with an average prevalence of 23...
May 1, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28458099/flavanonol-glucosides-from-the-aerial-parts-of-agrimonia-pilosa-ledeb-and-their-acetylcholinesterase-inhibitory-effects
#17
U Min Seo, Duc Hung Nguyen, Bing Tian Zhao, Byung Sun Min, Mi Hee Woo
Two new flavanonol glucoside isomers, (2R,3S)-dihydrokaempferol 3-O-β-D-glucoside (1) and (2S,3R)-dihydrokaempferol 3-O-β-D-glucoside (2), were isolated from the aerial parts of Agrimonia pilosa Ledeb., along with eight known flavanonol glucosides (3-10). Their structures were determined on the basis of spectroscopic analysis. In addition, these compounds were evaluated to determine their acetylcholinesterase inhibitory activities. The results indicated that these compounds have moderate inhibitory effects, with IC50 values ranging from 76...
April 15, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28454648/the-siglec14-null-allele-is-associated-with-mycobacterium-tuberculosis-and-bcg-induced-clinical-and-immunologic-outcomes
#18
Andrew D Graustein, David J Horne, Jerry J Fong, Flavio Schwarz, Heather C Mefford, Glenna J Peterson, Richard D Wells, Munyaradzi Musvosvi, Muki Shey, Willem A Hanekom, Mark Hatherill, Thomas J Scriba, Nguyen Thuy Thuong Thuong, Nguyen Thi Hoang Mai, Maxine Caws, Nguyen Duc Bang, Sarah J Dunstan, Guy E Thwaites, Ajit Varki, Takashi Angata, Thomas R Hawn
Humans exposed to Mycobacterium tuberculosis (Mtb) have variable susceptibility to tuberculosis (TB) and its outcomes. Siglec-5 and Siglec-14 are members of the sialic-acid binding lectin family that regulate immune responses to pathogens through inhibitory (Siglec-5) and activating (Siglec-14) domains. The SIGLEC14 coding sequence is deleted in a high proportion of individuals, placing a SIGLEC5-like gene under the expression of the SIGLEC14 promoter (the SIGLEC14 null allele) and causing expression of a Siglec-5 like protein in monocytes and macrophages...
May 2017: Tuberculosis
https://www.readbyqxmd.com/read/28447451/improvement-of-a-p450-based-recombinant-escherichia-coli-whole-cell-system-for-the-production-of-oxygenated-sesquiterpene-derivatives
#19
Thuy T B Ly, Alexander Schifrin, Bach Duc Nguyen, Rita Bernhardt
Sesquiterpenes are common constituents of essential oil in plants. Their oxygenated derivatives often possess desirable flavor, fragrance, and pharmaceutical properties. Recently, the CYP264B1-based recombinant Escherichia coli whole-cell system has been constructed for the oxidation of sesquiterpenes. However, limiting factors of this system related to the high volatility of substrates and the suitability of the P450 redox partner need to be addressed. In this work, the improvement of the system was implemented with (+)-α-longipinene as a model substrate...
May 4, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28447155/fine-tuned-evaluation-of-olfactory-function-in-patients-operated-for-nasal-polyposis
#20
Marie-Hortense Sonnet, Duc Trung Nguyen, Phi-Linh Nguyen-Thi, Fabien Arous, Roger Jankowski, Cécile Rumeau
Given the forced-choice procedure of the identification test, patients with profound anosmia are more likely to have higher identification scores by chance than patients with hyposmia or normosmia. This may be a confusing factor when assessing the sense of smell, which alters the appreciation of real olfaction improvement. The aim of this study was to fine-tune the results of the identification Sniffin' Sticks test before and 6 weeks after surgery using the real identification score. A total of 133 patients underwent the Identification (I) and Threshold (T) tests the day before and 6 weeks after nasalization surgery...
April 26, 2017: European Archives of Oto-rhino-laryngology
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