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Duc Nguyen

Dang Thi Thanh Huyen, Duong Thi Hong, Nguyen Thanh Trung, Tran Thi Nguyen Hoa, Nguyen Kieu Oanh, Ho Vinh Thang, Nguyen Thi Thanh Thao, Do Manh Hung, Makiko Iijima, Kimberley Fox, Varja Grabovac, James Heffelfinger, Nyambat Batmunkh, Dang Duc Anh
A prospective, multicentre study was conducted in four sentinel surveillance hospitals to assess the trend and epidemiology of acute diarrhea caused by Rotavirus in Vietnam. During the period 2012-2015, a total 8,889 children under 5 years of age were enrolled in the surveillance, and 8689 stool samples were collected. Of these cases, Rotavirus was most common pathogen 46.7% (4054 cases); in which 26.6% (1117) rotavirus-positive stool samples were evaluated to identify genotypes. The proportion of rotavirus positive specimens decreased annually from 54...
May 18, 2018: Vaccine
Nguyen Thanh Tam, Tran Duc Quan, Dang Viet Hau, Nguyen Thi Hoang Anh, Thi Thanh Thuy Tran, Nguyen Hoang Sa, Dao Duc Thien, Le Thi Hong Nhung, Dinh Thi Phong, Sabrina Adorisio, Domenico V Delfino, Trinh Thi Thuy
A new diterpene, cassipouryl hexadecanoate (2), in addition to the cassipourol (1) and four terpenes (3-6) were isolated from the twigs and leaves of Dacrycarpus imbricatus (Blume) de Laub. The structures of the two monocyclic diterpenes (1, 2), were elucidated on the basic of 1D and 2D NMR spectroscopic data and compared with the literature. These two monocyclic diterpenes (1, 2) were tested for their anti-proliferative activity on acute myeloid leukemia (OCI-AML) cells. The results showed that 1 had significantly anti-proliferative activity whereas 2 was weakly active...
May 21, 2018: Natural Product Research
Leif Eriksson, Nguyen T Nga, Dinh T Phuong Hoa, Duong M Duc, Anna Bergström, Lars Wallin, Mats Målqvist, Uwe Ewald, Tran Q Huy, Nguyen T Thuy, Tran Thanh Do, Pham T L Lien, Lars-Åke Persson, Katarina Ekholm Selling
BACKGROUND: Little is know about whether the effects of community engagement interventions for child survival in low-income and middle-income settings are sustained. Seasonal variation and secular trend may blur the data. Neonatal mortality was reduced in a cluster-randomised trial in Vietnam where laywomen facilitated groups composed of local stakeholders employing a problem-solving approach for 3 years. In this analysis, we aim at disentangling the secular trend, the seasonal variation and the effect of the intervention on neonatal mortality during and after the trial...
May 15, 2018: Journal of Epidemiology and Community Health
Dinh-Duc Nguyen, Dong Gyu Lee, Sinae Kim, Keunsoo Kang, Je-Keun Rhee, Suhwan Chang
BRCA1 is a multifunctional tumor suppressor involved in several essential cellular processes. Although many of these functions are driven by or related to its transcriptional/epigenetic regulator activity, there has been no genome-wide study to reveal the transcriptional/epigenetic targets of BRCA1. Therefore, we conducted a comprehensive analysis of genomics/transcriptomics data to identify novel BRCA1 target genes. We first analyzed ENCODE data with BRCA1 chromatin immunoprecipitation (ChIP)-sequencing results and identified a set of genes with a promoter occupied by BRCA1...
May 14, 2018: International Journal of Molecular Sciences
Anh Kim Dang, Bach Xuan Tran, Cuong Tat Nguyen, Huong Thi Le, Hoa Thi Do, Hinh Duc Nguyen, Long Hoang Nguyen, Tu Huu Nguyen, Hue Thi Mai, Tho Dinh Tran, Chau Ngo, Thuc Thi Minh Vu, Carl A Latkin, Melvyn W B Zhang, Roger C M Ho
This study aimed to examine: (1) how the Internet has changed consumers food-buying behavior and identify its associated factors; (2) consumers' concern about food safety information of online food products. A cross-sectional study was performed from October to December 2015 in Hanoi-a Vietnamese epicenter of food service. One thousand seven hundred and thirty six (1736) customers were randomly chosen from food establishments of 176 communes. Data were collected through face-to-face interviews using structured questionnaires...
May 14, 2018: International Journal of Environmental Research and Public Health
Karen A Alroy, Trang Thuy Do, Phu Dac Tran, Tan Quang Dang, Long Ngoc Vu, Nga Thi Hang Le, Anh Duc Dang, Nghia Duy Ngu, Tu Huy Ngo, Phuong Mai Vu Hoang, Lan Trong Phan, Thuong Vu Nguyen, Long Thanh Nguyen, Thinh Viet Nguyen, Mai Quang Vien, Huy Xuan Le, Anh The Dao, Trieu Bao Nguyen, Duoc Tho Pham, Van Thi Tuyet Nguyen, Thanh Ngoc Pham, Binh Hai Phan, Brett Whitaker, Thuy Thi Thu Do, Phuong Anh Dao, S Arunmozhi Balajee, Anthony W Mounts
BACKGROUND: In 2016, as a component of the Global Health Security Agenda, the Vietnam Ministry of Health expanded its existing influenza sentinel surveillance for severe acute respiratory infections (SARI) to include testing for 7 additional viral respiratory pathogens. This article describes the steps taken to implement expanded SARI surveillance in Vietnam and reports data from 1 year of expanded surveillance. METHOD: The process of expanding the suite of pathogens for routine testing by real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) included laboratory trainings, procurement/distribution of reagents, and strengthening and aligning SARI surveillance epidemiology practices at sentinel sites and regional institutes (RI)...
May 13, 2018: Influenza and Other Respiratory Viruses
Duc Tuan Cao, Van Hieu Tran, Van Nam Vu, Huong Doan Thi Mai, Thi Hong Minh Le, Thi Quyen Vu, Hung Huy Nguyen, Van Minh Chau, Van Cuong Pham
Analysis of an antimicrobial extract prepared from culture broth of the marine-derived actinomycete Streptomyces sp. G278 led to the isolation of ten compounds, 1-10. Two compounds, 2,5-Bis(5-tert-butyl-2-benzoxazolyl)thiophene (1), and 3-hydroxyl-2-methylpyridine (2) were isolated from a natural source for the first time. The structures of the isolated compounds were established by their spectral data analysis, including mass spectrometry, 1D-NMR, 2D-NMR, and X-ray crystallographic analysis in case of compound 3...
May 4, 2018: Natural Product Research
Hoang-Nhat-Phong Vo, Xuan-Thanh Bui, Thanh-Tin Nguyen, Dinh Duc Nguyen, Thanh-Son Dao, Ngoc-Dan-Thanh Cao, Thi-Kim-Quyen Vo
Photobioreactor technology, especially bubble column configuration, employing microalgae cultivation (e.g., Chlorella sp.), is an ideal man-made environment to achieve sufficient microalgae biomass through its strictly operational control. Nutrients, typically N and P, are necessary elements in the cultivation process, which determine biomass yield and productivity. Specifically, N:P ratios have certain effects on microalgae's biomass growth. It is also attractive that microalgae can sequester CO2 by using that carbon source for photosynthesis and, subsequently, reducing CO2 emission...
April 28, 2018: Journal of Environmental Management
Phong Dinh Tran, Linh N Nguyen, Thi Dieu Thuy Ung, Quang Duc Truong, Itaru Honma, Quang Liem Nguyen
Thin film of amorphous tungsten-doped cobalt oxide (W:CoO) was successfully grown on a conducting electrode via an electrochemical oxidation process employing a [Co(WS4)2]2- deposition bath. The W:CoO catalyst displays attractive performance for the oxygen evolution reaction in an alkaline solution. In the pH 13 NaOH solution, the best W:CoO operates with moderate onset overpotential of 230 mV and requires 320 mV overpotential to generate a catalytic current density of 10 Low Tafel slope of 45 mV.decade-1 was determined, indicating a rapid O2-evolving kinetics...
April 30, 2018: Chemistry, An Asian Journal
Xuan-Duc Nguyen, Torsten J Schulze, Peter Bugert, Stephanie Lauber-Härtl, Monika Schulz-Linkholt, Karen González-Schulze, Angelika Reil, Thomas Dengler, Simon Panzer, Erhard Seifried
BACKGROUND: White blood cell-associated antibodies can lead to transfusion-related acute lung injury (TRALI). Female donors with a history of pregnancies have been identified as a main cause for these antibodies. Male or female donors without a history of pregnancy are considered as safe donors. STUDY DESIGN AND METHODS: Following the identification of two TRALI cases associated with blood products from male donors, we investigated the frequency of granulocyte-specific and human leukocyte antigen (HLA) antibodies in the entire blood donor population using a high throughput automated flow-cytometry-based granulocyte immunofluorescence test (Flow-GIFT)...
April 29, 2018: Transfusion
Duc-Hau Le, Doanh Nguyen-Ngoc
Computational drug repositioning has been proven as a promising and efficient strategy for discovering new uses from existing drugs. To achieve this goal, a number of computational methods have been proposed, which are based on different data sources of drugs and diseases. These methods approach the problem using either machine learning- or network-based models with an assumption that similar drugs can be used for similar diseases to identify new indications of drugs. Therefore, similarities between drugs and between diseases are usually used as inputs...
April 26, 2018: Acta Biotheoretica
Tran Thi Thuong Huyen, Tran Thi Kim Chi, Nguyen Duc Dung, Hendrik Kosslick, Nguyen Quang Liem
Rutile TiO₂ with highly active facets has attracted much attention owing to its enhanced activity during the photocatalytic degradation of pollutants such as pharmaceuticals in wastewater. However, it is difficult to obtain by controlling the synthetic conditions. This paper reports a simple hydrothermal synthesis of rutile TiO₂ nanorods with highly exposed {110} facets. The obtained rutile was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HR-TEM), and Raman spectroscopy...
April 25, 2018: Nanomaterials
Duc Nguyen, Gyeongwon Kang, Naihao Chiang, Xu Chen, Tamar Seideman, Mark C Hersam, George C Schatz, Richard P Van Duyne
Ultrahigh vacuum tip-enhanced Raman spectroscopy (UHV-TERS) is used to investigate adsorption of molecular oxygen (O2 ) on cobalt (II) phthalocyanine (CoPc) supported on Ag(111) single crystal surfaces, which is the initial step for the oxygen reduction reaction (ORR) using metal Pc catalysts. Two adsorption configurations are primarily observed, assigned as O2 /CoPc/Ag(111) and O/CoPc/Ag(111) based on scanning tunneling microscopy (STM) imaging, TERS, isotopologue substitution, and density functional theory (DFT) calculations...
April 23, 2018: Journal of the American Chemical Society
Richard J Knight, Edward A Graviss, Duc T Nguyen, Samantha A Kuten, Samir J Patel, Lillian Gaber, A Osama Gaber
BACKGROUND: We sought to determine if conversion from tacrolimus/mycophenolate mofetil (TAC-MMF) to tacrolimus/mTOR inhibitor (TAC-mTOR) immunosuppression would reduce the incidences of BK and CMV viremia after kidney/pancreas (KP) transplantation. METHODS: In this single center review, the TAC-mTOR cohort (n=39) was converted at one month post-transplant to an mTOR inhibitor and reduced dose tacrolimus. Outcomes were compared to a cohort of KP recipients (n=40) maintained on TAC-MMF...
April 19, 2018: Clinical Transplantation
Dea Hyun Moon, Sang Moon Lee, Jeong Yoon Ahn, Dinh Duc Nguyen, Sung Su Kim, Soon Woong Chang
Ni-based quaternary disk catalysts were manufactured for low-temperature CO2 methanation reactions, and the reaction activity was examined with respect to the thermal treatment conditions. By applying varying reduction and combustion treatments, the same catalysts were compared, and the Ni oxidation conditions and physical features were confirmed through X-Ray diffraction, scanning electron microscopy, and energy dispersive X-ray analyses. In addition, oxygen adsorption/desorption changes were measured by temperature-programmed reduction after pre-treating with oxygen and hydrogen...
April 16, 2018: Journal of Environmental Management
Anh Duc Nguyen, In Yeub Hwang, Ok Kyung Lee, Donghyuk Kim, Marina G Kalyuzhnaya, Rina Mariyana, Susila Hadiyati, Min Sik Kim, Eun Yeol Lee
Methane is considered a next-generation feedstock, and methanotrophic cell-based biorefinery is attractive for production of a variety of high-value compounds from methane. In this work, we have metabolically engineered Methylomicrobium alcaliphilum 20Z for 2,3-butanediol (2,3-BDO) production from methane. The engineered strain 20Z/pBudK.p, harboring the 2,3-BDO synthesis gene cluster (budABC) from Klebsiella pneumoniae, accumulated 2,3-BDO in methane-fed shake flask cultures with a titer of 35.66mg/L. Expression of the most efficient gene cluster was optimized using selection of promoters, translation initiation rates (TIR), and the combination of 2,3-BDO synthesis genes from different sources...
April 16, 2018: Metabolic Engineering
Gita V Soraya, Jianxiong Chan, Thanh C Nguyen, Duc H Huynh, Chathurika D Abeyrathne, Gursharan Chana, Marian Todaro, Efstratios Skafidas, Patrick Kwan
Prevention of life threatening hypersensitivity reactions to carbamazepine is possible through pre-treatment screening of the associated HLA-B*15:02 risk allele. However, clinical implementation of screening is hindered by the high cost and slow turnaround of conventional HLA typing methods. We have developed an interdigitated electrode (IDE) biosensor platform utilizing loop mediated isothermal amplification (LAMP) that can rapidly detect the HLA-B*15:02 allele. DNA amplification is followed by solid-phase hybridization of LAMP amplicons to a DNA probe immobilized on the IDE sensor surface, resulting in a change in sensor impedance...
February 2, 2018: Biosensors & Bioelectronics
Ryan B Griggs, Leonid M Yermakov, Domenica E Drouet, Duc V M Nguyen, Keiichiro Susuki
Nodes of Ranvier and associated paranodal and juxtaparanodal domains along myelinated axons are essential for normal function of the peripheral and central nervous systems. Disruption of these domains as well as increases in the reactive carbonyl species methylglyoxal are implicated as a pathophysiology common to a wide variety of neurological diseases. Here, using an ex vivo nerve exposure model, we show that increasing methylglyoxal produces paranodal disruption, evidenced by disorganized immunostaining of axoglial cell-adhesion proteins, in both sciatic and optic nerves from wild-type mice...
January 2018: ASN Neuro
Duc-Loc Nguyen, Catriona Wimberley, Charles Truillet, Benoit Jego, Fabien Caillé, Géraldine Pottier, Raphaël Boisgard, Irène Buvat, Viviane Bouilleret
OBJECTIVE: Mesiotemporal lobe epilepsy is the most common type of drug-resistant partial epilepsy, with a specific history that often begins with status epilepticus due to various neurological insults followed by a silent period. During this period, before the first seizure occurs, a specific lesion develops, described as unilateral hippocampal sclerosis (HS). It is still challenging to determine which drugs, administered at which time point, will be most effective during the formation of this epileptic process...
April 19, 2018: Epilepsia
Duc T Nguyen, Helen E Jenkins, Edward A Graviss
BACKGROUND: Estimating mortality risk during TB treatment in HIV co-infected patients is challenging for health professionals, especially in a low TB prevalence population, due to the lack of a standardized prognostic system. The current study aimed to develop and validate a simple mortality prognostic scoring system for TB/HIV co-infected patients. METHODS: Using data from the CDC's Tuberculosis Genotyping Information Management System of TB patients in Texas reported from 01/2010 through 12/2016, age ≥15 years, HIV(+), and outcome being "completed" or "died", we developed and internally validated a mortality prognostic score using multiple logistic regression...
2018: PloS One
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