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https://www.readbyqxmd.com/read/29928607/risk-factors-for-poor-outcome-in-posterior-reversible-encephalopathy-syndrome-systematic-review-and-meta-analysis
#1
Zheng Chen, Gang Zhang, Alexander Lerner, An-Hui Wang, Bo Gao, Jie Liu
Background: The roles of clinical etiology and symptoms, imaging findings and biochemical parameters in predicting the prognosis of posterior reversible encephalopathy syndrome (PRES) have not been well-characterized. We perform a meta-analysis of all published studies to assess the value of various risk factors in predicting the prognosis of PRES. Methods: Searches of the PubMed, EMBASE, Cochrane Library, and Web of Science databases were performed to identify the eligible studies...
May 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29925546/vitamin-d-and-risk-of-pregnancy-related-hypertensive-disorders-mendelian-randomisation-study
#2
Maria C Magnus, Kozeta Miliku, Anna Bauer, Stephanie M Engel, Janine F Felix, Vincent W V Jaddoe, Debbie A Lawlor, Stephanie J London, Per Magnus, Ralph McGinnis, Wenche Nystad, Christian M Page, Fernando Rivadeneira, Lars C Stene, German Tapia, Nicholas Williams, Carolina Bonilla, Abigail Fraser
OBJECTIVE: To use mendelian randomisation to investigate whether 25-hydroxyvitamin D concentration has a causal effect on gestational hypertension or pre-eclampsia. DESIGN: One and two sample mendelian randomisation analyses. SETTING: Two European pregnancy cohorts (Avon Longitudinal Study of Parents and Children, and Generation R Study), and two case-control studies (subgroup nested within the Norwegian Mother and Child Cohort Study, and the UK Genetics of Pre-eclampsia Study)...
June 20, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29925329/incidence-and-determinants-of-severe-maternal-outcome-in-jimma-university-teaching-hospital-south-west-ethiopia-a-prospective-cross-sectional-study
#3
Wondimagegnehu Sisay Woldeyes, Dejene Asefa, Geremew Muleta
BACKGROUND: Investigating cases of severe maternal morbidity (SMM) and severe maternal outcome (SMO) and the quality of maternal health care using near-miss approach has become popular over recent years. The aim of this study was to determine facility based incidence and the determinants of severe maternal outcome (SMO) using this approach. METHODS: Prospective cross-sectional study among all mothers who presented to study facility while pregnant, during child birth and/or within 42 days after termination of pregnancy seeking care and found to have SMM and SMO during the study period was carried out...
June 20, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29923045/assessment-of-relationship-of-serum-neurokinin-b-level-in-the-pathophysiology-of-pre-eclampsia-a-case-control-study
#4
Henna Salman, Mohsin Shah, Asif Ali, Asma Aziz, Salvatore Giovanni Vitale
INTRODUCTION: Pre-eclampsia is a pregnancy-induced disorder that complicates approximately 5-7% of pregnancies. It is the leading cause of maternal and foetal morbidity and mortality worldwide. AIM: To determine the role of serum neurokinin-B level in the pathophysiology of pre-eclampsia. METHODS: This was a case-control study. A total of 80 pregnant women in their third trimester of pregnancy were included in the study. They were divided into two groups (40 pre-eclamptic and 40 normotensive) according to the presence or absence of clinical parameters of pre-eclampsia...
June 19, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29917286/quality-assessment-of-uterine-artery-doppler-measurement-in-first-trimester-combined-screening-for-pre-eclampsia
#5
Daniel L Rolnik, Fabricio da Silva Costa, Daljit Sahota, Jon Hyett, Andrew McLennan
AIM: To assess the quality of mean uterine artery pulsatility index (UtAPI) measurement in a first trimester pre-eclampsia screening program. METHODS: Consecutive patients attending first trimester screening for fetal chromosomal abnormalities also had combined screening for pre-eclampsia based on the Fetal Medicine Foundation (FMF) algorithm, in a large practice in Sydney, Australia, from May 2014 to February 2017. Distributions of mean UtAPI multiples of the median (MoM) on the logarithmic scale were plotted in relation to the normal median with 95% confidence interval (CI) for each operator and for each month...
June 19, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29916133/three-dimensional-indices-of-renal-perfusion-in-normal-pregnancy-and-pre-eclampsia
#6
Amanda Ali, Susan Addley, Stephen Ong
INTRODUCTION: We compared renal perfusion in normal pregnant women and women with pre-eclampsia using three-dimensional (3D) ultrasound. We measured the flow index (FI), vascular index (VI) and vascularisation flow index (VFI) which are believed to reflect vascularity and flow intensity. METHODS: Fourteen patients with normal pregnancy and 16 patients with pre-eclampsia were recruited. Imaging was conducted using a Voluson E8 machine and a 6-MHz trans-abdominal probe...
June 18, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29915651/posterior-reversible-encephalopathy-syndrome-pres-after-bevacizumab-therapy-for-metastatic-colorectal-cancer
#7
Mohsin Hamid, Ali Ghani, Ida Micaily, Usman Sarwar, Bilal Lashari, Faizan Malik
Posterior reversible encephalopathy syndrome (PRES) is an increasingly recognizable neuro-clinical syndrome. Clinical and neurological manifestations of PRES include hypertension, headache, encephalopathy, seizures, and symmetrical white matter changes on brain MRI. Most common precipitants of PRES are acute medical illness, hypertensive crisis, eclampsia, immunosuppressive therapy, and chemotherapy. Bevacizumab is a monoclonal antibody that halts angiogenesis by inhibiting vascular endothelial growth factor...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29914672/lipid-profile-plasma-apolipoproteins-and-pre-eclampsia-risk-in-the-genpe-case-control-study
#8
Norma C Serrano, Elizabeth Guio-Mahecha, Doris Cristina Quintero-Lesmes, Silvia Becerra-Bayona, María C Paez, Mónica Beltran, Víctor M Herrera, Lydia J Leon, David Williams, Juan P Casas
BACKGROUND AND AIMS: Pre-eclampsia constitutes a leading cause of maternal and perinatal morbidity and mortality. Pre-eclampsia susceptibility is believed to be associated with altered lipid profiles and abnormal lipid metabolism via lipid peroxidation that leads to endothelial dysfunction. The goal of this study was to evaluate the association of maternal blood lipid and apolipoprotein levels with pre-eclampsia in a large-scale study. METHODS: Using data from a large case-control study (1366 cases of pre-eclampsia and 1741 normotensive controls), the association between the distributions of eight lipid fractions and pre-eclampsia risk was evaluated using adjusted logistic regression models...
June 4, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29914393/stillbirth-surveillance-and-review-in-rural-districts-in-bangladesh
#9
Abdul Halim, Mamuda Aminu, Juan Emmanuel Dewez, Animesh Biswas, A K M Fazlur Rahman, Nynke van den Broek
BACKGROUND: An estimated 2.6 million stillbirths occur every year, with the majority occurring in low- and middle-income countries. Understanding the cause of and factors associated with stillbirth is important to help inform the design and implementation of interventions aimed at reducing preventable stillbirths. METHODS: Population-based surveillance with identification of all stillbirths that occurred either at home or in a health facility was introduced in four districts in Bangladesh...
June 13, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29914278/maternal-fetal-and-neonatal-outcome-among-different-types-of-hypertensive-disorders-associating-pregnancy-needing-intensive-care-management
#10
Ahmed M Maged, Ameer Elsherief, Hany Hassan, Doaa Salaheldin, Khaled A Omran, Maged Almohamady, Sherif Dahab, Radwa Fahmy, Ahmed AbdelHak, Amira Y Shoab, Rehab Lotfy, Yossra S Lasheen, Hala Nabil, Sahar M Y Elbaradie
OBJECTIVE: To assess the relation between maternal, fetal and neonatal outcomes and different forms of hypertensive disorders associating pregnancy in women needed intensive care units (ICU) admission. METHODS: A prospective case control study conducted on 1238 women admitted to hypertensive intensive care unit at three university hospitals. They were classified into four groups. Group I included 472 women with severe preeclampsia (PE), Group II included 243 women with eclampsia (E); Group III included 396 women diagnosed with E associated with HELLP syndrome and Group IV included 127 women diagnosed as HELLP syndrome...
June 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29908643/investigating-human-placentation-and-pregnancy-using-first-trimester-chorionic-villi
#11
Roberta L Hannibal, Margarida Cardoso-Moreira, Shilpa P Chetty, Joanne Lau, Zhongxia Qi, Eduardo Gonzalez-Maldonado, Athena M Cherry, Jingwei Yu, Mary E Norton, Julie C Baker
Chorionic villus sampling (CVS), routinely used for prenatal diagnosis of cytogenetic disorders, also possesses great potential for the study of placentation. To better understand villus biology, human placentation, and how these relate to pregnancy outcomes, we examined the morphology and transcriptomes of villi obtained via CVS from 10 to 14 weeks of pregnancy and correlated these with pregnancy attributes and clinical outcomes. First, we established a morphological scoring system based on three main villus features: branching, budding and vascularization...
May 2018: Placenta
https://www.readbyqxmd.com/read/29907426/maternal-obesity-as-a-risk-factor-for-the-development-of-total-anomalous-pulmonary-venous-connection-in-their-offspring
#12
Evelyn G Alvarado-Terrones, Maryangel Perea-Cabrera, Miguel Klünder-Klünder, Begoña Segura-Stanford, Julio R Erdmenger-Orellana, Arturo Lopez-Yañez Blanco, Elizabeth Hernández-Carbajal, Javier T Granados Riverón, Leonardo J Mejía-Marín, Norma A Balderrabano-Saucedo, Alejandra Contreras-Ramos, Guadalupe Díaz-Rosas, Rocío Sánchez-Urbina
The incidence of total anomalous pulmonary venous connection (TAPVC) in the Caucasian population is 2.5/100,000 live births (LB), and the incidence in the Hispanic population is 19.8/100,000 LB. Without knowing the exact etiology for the development of congenital heart disease, our objective was to determine the maternal factors associated with the development of TAPVC. METHODS: 55 mother-child binomials with isolated TAPVC (group I) and 152 healthy mother-child binomials (group II) were included...
June 12, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29907146/are-women-with-history-of-pre-eclampsia-starting-a-new-pregnancy-in-good-nutritional-status-in-south-africa-and-zimbabwe
#13
Gabriela Cormick, Ana Pilar Betrán, Janetta Harbron, Tina Dannemann Purnat, Catherine Parker, David Hall, Armando H Seuc, James M Roberts, José M Belizán, G Justus Hofmeyr
BACKGROUND: Maternal nutritional status before and during pregnancy is an important contributor to pregnancy outcomes and early child health. The aim of this study was to describe the preconceptional nutritional status and dietary intake during pregnancy in high-risk women from South Africa and Zimbabwe. METHODS: This is a prospective observational study, nested to the CAP trial. Anthropometric measurements before and during pregnancy and dietary intake using 24-h recall during pregnancy were assessed...
June 15, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29898693/peripartum-fetal-distress-in-diabetic-women-a-retrospective-case-cohort-study
#14
B Castelijn, Kwp Hollander, J F Hensbergen, R G IJzerman, A W Valkenburg-van den Berg, Jwr Twisk, Cjm De Groot, Mgaj Wouters
BACKGROUND: Major concerns of pregnancies complicated by diabetes mellitus are an increased risk of adverse perinatal outcome. The objective of this study was to analyse the rate of fetal distress during labor in women with type 1, type 2 and gestational diabetes compared to control women. METHODS: A retrospective case-cohort study was conducted at the VU University Medical Center, Amsterdam; a tertiary care hospital. 117 women with type 1 diabetes, 59 women with type 2 diabetes, 303 women with gestational diabetes and 15,260 control women were included, who delivered between March 2004 and February 2014...
June 14, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29898442/a-novel-early-pregnancy-risk-prediction-model-for-gestational-diabetes-mellitus
#15
Arianne N Sweeting, Jencia Wong, Heidi Appelblom, Glynis P Ross, Heikki Kouru, Paul F Williams, Mikko Sairanen, Jon A Hyett
INTRODUCTION: Accurate early risk prediction for gestational diabetes mellitus (GDM) would target intervention and prevention in women at the highest risk. We evaluated novel biomarker predictors to develop a first-trimester risk prediction model in a large multiethnic cohort. METHODS: Maternal clinical, aneuploidy and pre-eclampsia screening markers (PAPP-A, free hCGβ, mean arterial pressure, uterine artery pulsatility index) were measured prospectively at 11-13+6 weeks' gestation in 980 women (248 with GDM; 732 controls)...
June 13, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29896812/screening-for-pre-eclampsia-by-maternal-factors-and-biomarkers-at-11-13-weeks-gestation
#16
Min Yi Tan, Argyro Syngelaki, Liona C Poon, Daniel L Rolnik, Neil O'Gorman, Juan Luis Delgado, Ranjit Akolekar, Liountmila Konstantinidou, Maria Tsavdaridou, Slavyana Galeva, Ursula Ajdacka, Francisca S Molina, Nicola Persico, Jacques C Jani, Walter Plasencia, Elena Greco, George Papaioannou, Alan Wright, David Wright, Kypros H Nicolaides
OBJECTIVE: To examine the performance of screening for early-, preterm- and term-preeclampsia (PE) at 11-13 weeks' gestation by maternal factors and combinations of mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), serum placental growth factor (PLGF) and serum pregnancy associated plasma protein-A (PAPP-A). METHODS: The data for this study were derived from three previously reported prospective non-intervention screening studies at 11+0 - 13+6 weeks' gestation in a combined total of 61,174 singleton pregnancies, including 1,770 (2...
June 13, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29896778/screening-for-pre-eclampsia-at-35-37-weeks-gestation
#17
Anca Panaitescu, Anca Ciobanu, Argyro Syngelaki, Alan Wright, David Wright, Kypros H Nicolaides
OBJECTIVE: To examine the performance of screening for preeclampsia (PE) at 35-37 weeks' gestation by maternal factors and combinations of mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), serum placental growth factor (PLGF) and serum soluble fms-like tyrosine kinase-1 (sFLT). METHODS: This was a prospective observational study in women with singleton pregnancies attending for an ultrasound scan at 35+0 - 36+6 weeks as part of routine pregnancy care...
June 13, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29895936/int6-eif3e-silencing-promotes-placenta-angiogenesis-in-a-rat-model-of-pre-eclampsia
#18
Qin Li, Baolin Yao, Alexander Endler, Li Chen, Futoshi Shibasaki, Haidong Cheng
We investigated whether stable eukaryotic translation initiation factor 3e/inter 6 (eIF-3e/Int6) RNA-silencing (siRNA-Int6) can ameliorate pre-eclampsia (PE) by promoting angiogenesis in an N-nitro-L-arginine methyl ester (L-NAME)-induced rat pre-eclampsia (PE) model. Twenty-four pregnant female Sprague-Dawley rats were allocated into 4 groups, including controls (Con) without any treatment, and 18 from gestational day (GD) 7 to GD17 L-NAME-treated rats, which were divided into stable siRNA-Int6 transfected (siRNA-Int6), negative vector control siRNA (NC-siRNA) and PE control (PE-Con) groups...
June 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29893994/predictive-factors-for-successful-cervical-ripening-using-a-double-balloon-catheter-after-previous-cesarean-delivery
#19
Mathilde Vital, Joséphine Grange, Aurélie Le Thuaut, Jérôme Dimet, Guillaume Ducarme
OBJECTIVE: To identify predictors of successful cervical ripening using double-balloon catheter (DBC) for labor induction among women with previous cesarean delivery (PCD) and unfavorable cervix at term. METHODS: The present prospective observational study was conducted among women who underwent cervical ripening with DBC at a French tertiary care hospital between January 1, 2014, and December 31, 2017. Inclusion criteria were PCD; singleton term fetus; cephalic presentation; and unfavorable cervix (Bishop score <6)...
June 12, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29892993/pre-pregnancy-weight-loss-in-women-with-obesity-requesting-removal-of-their-intra-uterine-contraceptive-device-in-order-to-conceive-a-pilot-study-of-full-meal-replacement
#20
L Brackenridge, N Finer, R L Batterham, K Pedram, T Ding, J Stephenson, J Barry, P Hardiman
Obesity during pregnancy is associated with increased risks of thromboembolism, gestational diabetes, pre-eclampsia, miscarriage, congenital anomaly, macrosomia and stillbirth. The current practice, directed at reducing gestational weight gain, is largely ineffective. The present pilot study was designed to assess the acceptability of a 24-week intensive weight management programme (IWMP; full meal replacement followed by partial meal replacement and weight stabilization) to achieve weight loss for women with obesity requesting removal of their intra-uterine contraceptive device in order to conceive...
June 11, 2018: Clinical Obesity
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