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MULTICENTER STUDY
Sorena Keihani, Yizhe Xu, Angela P Presson, James M Hotaling, Raminder Nirula, Joshua Piotrowski, Christopher M Dodgion, Cullen M Black, Kaushik Mukherjee, Bradley J Morris, Sarah Majercik, Brian P Smith, Ian Schwartz, Sean P Elliott, Erik S DeSoucy, Scott Zakaluzny, Peter B Thomsen, Bradley A Erickson, Nima Baradaran, Benjamin N Breyer, Brandi Miller, Richard A Santucci, Matthew M Carrick, Timothy Hewitt, Frank N Burks, Jurek F Kocik, Reza Askari, Jeremy B Myers
BACKGROUND: The rarity of renal trauma limits its study and the strength of evidence-based guidelines. Although management of renal injuries has shifted toward a nonoperative approach, nephrectomy remains the most common intervention for high-grade renal trauma (HGRT). We aimed to describe the contemporary management of HGRT in the United States and also evaluate clinical factors associated with nephrectomy after HGRT. METHODS: From 2014 to 2017, data on HGRT (American Association for the Surgery of Trauma grades III-V) were collected from 14 participating Level-1 trauma centers...
March 2018: Journal of Trauma and Acute Care Surgery
#22
JOURNAL ARTICLE
Kerrie E McNally, Rebecca Faulkner, Florian Steinberg, Matthew Gallon, Rajesh Ghai, David Pim, Paul Langton, Neil Pearson, Chris M Danson, Heike Nägele, Lindsey L Morris, Amika Singla, Brittany L Overlee, Kate J Heesom, Richard Sessions, Lawrence Banks, Brett M Collins, Imre Berger, Daniel D Billadeau, Ezra Burstein, Peter J Cullen
Following endocytosis into the endosomal network, integral membrane proteins undergo sorting for lysosomal degradation or are retrieved and recycled back to the cell surface. Here we describe the discovery of an ancient and conserved multiprotein complex that orchestrates cargo retrieval and recycling and, importantly, is biochemically and functionally distinct from the established retromer pathway. We have called this complex 'retriever'; it is a heterotrimer composed of DSCR3, C16orf62 and VPS29, and bears striking similarity to retromer...
October 2017: Nature Cell Biology
#23
JOURNAL ARTICLE
A L Ho, L Dunn, E J Sherman, M G Fury, S S Baxi, R Chandramohan, S Dogan, L G T Morris, G D Cullen, S Haque, C S Sima, A Ni, C R Antonescu, N Katabi, D G Pfister
BACKGROUND: Recurrent/metastatic adenoid cystic carcinoma (ACC) is an incurable disease with no standard treatments. The majority of ACCs express the oncogenic transcription factor MYB (also c-myb), often in the context of a MYB gene rearrangement. This phase II trial of the tyrosine kinase inhibitor (TKI) axitinib (Pfizer) tested the hypothesis that targeting pathways activated by MYB can be therapeutically effective for ACC. PATIENTS AND METHODS: This is a minimax two-stage, phase II trial that enrolled patients with incurable ACC of any primary site...
October 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
#24
JOURNAL ARTICLE
Candis Lee Kles, C Patrick Murrah, Kerry Smith, Elizabeth Baugus-Wellmeier, Terri Hurry, Cullen D Morris
BACKGROUND: Surgical site infections (SSI) increase morbidity and mortality, hospital costs, length of stay, readmissions, and risk of litigation and may impact a facility's reputation. METHODS: Through implementation of a Six Sigma, interdisciplinary team process and the Contextual Model for change engaged all stakeholders. A total of 44 perioperative processes were evaluated, with 15 processes ultimately altered. Revisions involved identifying inconsistent implementation of procedures and standardizing processes, as well as utilizing new suture techniques and products including disposable electrocardiogram leads and pacing wires, antibiotic-coated sutures, and silver-impregnated midsternal dressings...
September 2015: Dimensions of Critical Care Nursing: DCCN
#25
JOURNAL ARTICLE
P R Shorten, C A Morris, N G Cullen
The goal was to estimate the heritabilities and genetic variances for pregnancy rate (PR) and calving date (CD) in Angus cattle along with the effect of weight, age, and sire on PR and CD. The data consisted of 4,999 records on PR and CD. Statistical models included year as a fixed effect; premating/postmating weight and age as covariates; and sire of embryo, maternal grandsire (MGS), and permanent maternal environmental effects as random effects. The models also included the interactions between herd and weight (weight change)...
April 2015: Journal of Animal Science
#26
JOURNAL ARTICLE
Carlie L Cullen, Thomas H J Burne, Nickolas A Lavidis, Karen M Moritz
Consumption of alcohol during pregnancy can have detrimental impacts on the developing hippocampus, which can lead to deficits in learning and memory function. Although high levels of alcohol exposure can lead to severe deficits, there is a lack of research examining the effects of low levels of exposure. This study used a rat model to determine if prenatal exposure to chronic low dose ethanol would result in deficits in learning and memory performance and if this was associated with morphological changes within the hippocampus...
2014: PloS One
#27
JOURNAL ARTICLE
Hannah Dickson, Alexis E Cullen, Abraham Reichenberg, Sheilagh Hodgins, Desmond D Campbell, Robin G Morris, Kristin R Laurens
Adults with schizophrenia present cognitive impairments, as do individuals at ultra-high risk for the disorder, youth with relatives with schizophrenia spectrum disorders, and children with antecedents of schizophrenia. The present study aimed to determine if impairments in childhood differed depending on the definition of risk and/or on the degree of relatedness to an affected individual, and if impairments were explained by IQ. Four groups of children aged 9-12 years were studied: (1) 13 children with ≥1 first-degree or ≥2 second-degree affected relatives (high familial loading: FHx(H)); (2) 14 with ≥1 affected second-degree relative (lower familial loading: FHx(L)); (3) 32 with well-replicated antecedents of schizophrenia (ASz); and (4) 45 typically-developing (TD) children with neither a positive family history nor antecedents...
March 2014: Journal of Psychiatric Research
#28
JOURNAL ARTICLE
J Mygatt, I Sesterhenn, I Rosner, Y Chen, J Cullen, T Morris-Gore, J Barton, A Dobi, S Srivastava, D McLeod, S A Brassell
BACKGROUND: To determine whether prostate cancers detected in the anterior vs posterior zones impact clinicopathological features and patient outcomes. This information could potentially affect clinical management. METHODS: A retrospective pathological review of 1528 radical prostatectomy specimens submitted between 1989 and 2011 was completed. Specimens were characterized as anterior zone vs posterior zone based on index tumor and predominant tumor volume location...
March 2014: Prostate Cancer and Prostatic Diseases
#29
JOURNAL ARTICLE
C A Morris, C D K Bottema, N G Cullen, S M Hickey, S O Knowles, W S Pitchford
A quantitative trait locus (QTL) study of the concentrations of 14 trace and macro elements (minerals) in tissues of beef cattle was conducted in New Zealand. Back-cross calves with Jersey and Limousin ancestry (202 heifers and 211 steers) were generated using first-cross sires. This paper reports on testing for effects of QTL on the concentrations of minerals in liver, kidney and muscle in cattle at slaughter, following a growth phase during which rearing and finishing stages were on pasture. Fifteen QTL were identified (P < 0...
August 2013: Animal Genetics
#30
JOURNAL ARTICLE
Zhan Su, Laura J Gay, Amy Strange, Claire Palles, Gavin Band, David C Whiteman, Francesco Lescai, Cordelia Langford, Manoj Nanji, Sarah Edkins, Anouk van der Winkel, David Levine, Peter Sasieni, Céline Bellenguez, Kimberley Howarth, Colin Freeman, Nigel Trudgill, Art T Tucker, Matti Pirinen, Maikel P Peppelenbosch, Luc J W van der Laan, Ernst J Kuipers, Joost P H Drenth, Wilbert H Peters, John V Reynolds, Dermot P Kelleher, Ross McManus, Heike Grabsch, Hans Prenen, Raf Bisschops, Kausila Krishnadath, Peter D Siersema, Jantine W P M van Baal, Mark Middleton, Russell Petty, Richard Gillies, Nicola Burch, Pradeep Bhandari, Stuart Paterson, Cathryn Edwards, Ian Penman, Kishor Vaidya, Yeng Ang, Iain Murray, Praful Patel, Weimin Ye, Paul Mullins, Anna H Wu, Nigel C Bird, Helen Dallal, Nicholas J Shaheen, Liam J Murray, Konrad Koss, Leslie Bernstein, Yvonne Romero, Laura J Hardie, Rui Zhang, Helen Winter, Douglas A Corley, Simon Panter, Harvey A Risch, Brian J Reid, Ian Sargeant, Marilie D Gammon, Howard Smart, Anjan Dhar, Hugh McMurtry, Haythem Ali, Geoffrey Liu, Alan G Casson, Wong-Ho Chow, Matt Rutter, Ashref Tawil, Danielle Morris, Chuka Nwokolo, Peter Isaacs, Colin Rodgers, Krish Ragunath, Chris MacDonald, Chris Haigh, David Monk, Gareth Davies, Saj Wajed, David Johnston, Michael Gibbons, Sue Cullen, Nicholas Church, Ruth Langley, Michael Griffin, Derek Alderson, Panos Deloukas, Sarah E Hunt, Emma Gray, Serge Dronov, Simon C Potter, Avazeh Tashakkori-Ghanbaria, Mark Anderson, Claire Brooks, Jenefer M Blackwell, Elvira Bramon, Matthew A Brown, Juan P Casas, Aiden Corvin, Audrey Duncanson, Hugh S Markus, Christopher G Mathew, Colin N A Palmer, Robert Plomin, Anna Rautanen, Stephen J Sawcer, Richard C Trembath, Ananth C Viswanathan, Nicholas Wood, Gosia Trynka, Cisca Wijmenga, Jean-Baptiste Cazier, Paul Atherfold, Anna M Nicholson, Nichola L Gellatly, Deborah Glancy, Sheldon C Cooper, David Cunningham, Tore Lind, Julie Hapeshi, David Ferry, Barrie Rathbone, Julia Brown, Sharon Love, Stephen Attwood, Stuart MacGregor, Peter Watson, Scott Sanders, Weronica Ek, Rebecca F Harrison, Paul Moayyedi, John de Caestecker, Hugh Barr, Elia Stupka, Thomas L Vaughan, Leena Peltonen, Chris C A Spencer, Ian Tomlinson, Peter Donnelly, Janusz A Z Jankowski
Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to esophageal adenocarcinoma (EAC), a tumor with a very poor prognosis. We report the first genome-wide association study on Barrett's esophagus, comprising 1,852 UK cases and 5,172 UK controls in the discovery stage and 5,986 cases and 12,825 controls in the replication stage. Variants at two loci were associated with disease risk: chromosome 6p21, rs9257809 (Pcombined=4...
October 2012: Nature Genetics
#31
JOURNAL ARTICLE
Rugang Tian, Neil G Cullen, Chris A Morris, Paul J Fisher, Wayne S Pitchford, Cynthia D K Bottema
Beef with yellow fat is considered undesirable by consumers in most European and Asian markets. β-Carotene is the major carotenoid deposited in the adipose tissue and milk fat of cattle (Bos taurus), which can result in the yellowness. The effects of retinal short-chain dehydrogenase reductase (RDHE2) and β, β-carotene 9',10-dioxygenase (BCO2) were considered jointly as major candidate genes for causing the yellow fat colour, based on their genomic locations in the fat colour quantitative trait loci (QTL) and their roles in the metabolism of β-carotene...
June 2012: Mammalian Genome: Official Journal of the International Mammalian Genome Society
#32
JOURNAL ARTICLE
Cullen D Morris, John D Puskas, Sorin V Pusca, Omar M Lattouf, William A Cooper, Thomas A Vassiliades, Edward P Chen, Vinod H Thourani, Patrick D Kilgo, Robert A Guyton
OBJECTIVE: : Application of off-pump techniques to reoperative coronary artery bypass (redo CABG) has been limited by technical difficulty and potential for embolism of atheromatous debris from diseased grafts, resulting in myocardial infarction and rapid hemodynamic deterioration. We compared outcomes after off-pump (OPCAB) and on-pump (ONCAB) in redo CABG. METHODS: : A retrospective chart review was performed for patients who underwent redo CABG at a single academic institution between January 1997 and December 2004...
January 2007: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
#33
JOURNAL ARTICLE
D S Theodoropoulos, D R Katzenberger, W M Jones, D L Morris, C Her, N A M Cullen, D L Morrisa
BACKGROUND: Inflammation is a cardinal feature of migraines. A number of observations point to the possibility that an allergic component of a type I (IgE-mediated) nature may be involved in at least some migraineurs. Not only are migraines frequent among patients with allergic rhinitis but quite frequently the same medical approaches are beneficial in both diseases: anti-inflammatories, adrenergic tone modifiers, immune suppressants. The effect that immunotherapy for allergic rhinitis has upon migraines is studied...
October 2011: European Review for Medical and Pharmacological Sciences
#34
JOURNAL ARTICLE
A K Esmailizadeh, C A Morris, N G Cullen, Z A Kruk, D S Lines, S M Hickey, P M Dobbie, C D K Bottema, W S Pitchford
A whole-genome scan was carried out in New Zealand and Australia to detect quantitative trait loci (QTL) for live animal and carcass composition traits and meat quality attributes in cattle. Backcross calves (385 heifers and 398 steers) were generated, with Jersey and Limousin backgrounds. The New Zealand cattle were reared and finished on pasture, whilst Australian cattle were reared on grass and finished on grain for at least 180 days. This paper reports on meat quality traits (tenderness measured as shear force at 4-5 ages on two muscles as well as associated traits of meat colour, pH and cooking loss) and a number of metabolic traits...
December 2011: Animal Genetics
#35
JOURNAL ARTICLE
Vinod H Thourani, W Brent Keeling, Eric L Sarin, Robert A Guyton, Patrick D Kilgo, Ameesh B Dara, John D Puskas, Edward P Chen, William A Cooper, J David Vega, Cullen D Morris, Michael E Halkos, Omar M Lattouf
BACKGROUND: The impact of the degrees of renal dysfunction (RD) after aortic valve replacement (AVR) has not been well described. The purpose of this study was to compare patients undergoing AVR with a range of renal function from normal to dialysis-dependence. METHODS: A retrospective review of 2,408 patients undergoing AVR with or without coronary artery bypass graft surgery (CABG) from January 1996 to March 2009 was performed. Glomerular filtration rate (GFR) was estimated for patients using the Modification of Diet in Renal Disease formula...
June 2011: Annals of Thoracic Surgery
#36
JOURNAL ARTICLE
Vinod H Thourani, Eric L Sarin, W Brent Keeling, Patrick D Kilgo, Robert A Guyton, Ameesh B Dara, John D Puskas, Edward P Chen, William A Cooper, J David Vega, Cullen D Morris, Omar M Lattouf
BACKGROUND: The objective of this study was to assess short-term and long-term outcomes after valve replacement with biologic or mechanical prostheses in patients with preoperative end-stage renal disease on chronic dialysis. METHODS: A retrospective review of patients with end-stage renal disease undergoing valve replacement from January 1996 through March 2008 at Emory Healthcare Hospitals was performed. Outcomes were compared using χ(2) tests and 2-sample t tests...
April 2011: Annals of Thoracic Surgery
#37
JOURNAL ARTICLE
Alexis E Cullen, Hannah Dickson, Sophie A West, Robin G Morris, Glenn L Mould, Sheilagh Hodgins, Robin M Murray, Kristin R Laurens
BACKGROUND: We previously developed a novel method of identifying children aged 9-12 years who may be at elevated risk of developing schizophrenia and the spectrum disorders because they present a triad of putative antecedents of schizophrenia (ASz). The present study aimed to determine whether ASz children also present neurocognitive deficits that are commonly observed in patients with schizophrenia. METHODS: Twenty-eight ASz children and 28 typically-developing (TD) children without the antecedents of schizophrenia completed a battery of neurocognitive tests assessing seven domains of function: General intelligence, scholastic achievement, verbal memory, visual memory, working memory, executive function (EF)-verbal fluency, and EF-inhibition...
August 2010: Schizophrenia Research
#38
JOURNAL ARTICLE
C A Morris, C D K Bottema, N G Cullen, S M Hickey, A K Esmailizadeh, B D Siebert, W S Pitchford
A QTL study of live animal and carcass traits in beef cattle was carried out in New Zealand and Australia. Back-cross calves (385 heifers and 398 steers) were generated, with Jersey and Limousin backgrounds. This paper reports on weights of eight organs (heart, liver, lungs, kidneys, spleen, gastro-intestinal tract, fat, and rumen contents) and 12 fat composition traits (fatty acid (FA) percentages, saturated and monounsaturated FA subtotals, and fat melting point). The New Zealand cattle were reared and finished on pasture, whilst Australian cattle were reared on grass and finished on grain for at least 180 days...
December 2010: Animal Genetics
#39
JOURNAL ARTICLE
R Tian, W S Pitchford, C A Morris, N G Cullen, C D K Bottema
beta, beta-carotene-9', 10'-dioxygenase (BCO2) plays a role in cleaving beta-carotene eccentrically, and may be involved in the control of adipose and milk colour in cattle. The bovine BCO2 gene was sequenced as a potential candidate gene for a beef fat colour QTL on chromosome (BTA) 15. A single nucleotide base change located in exon 3 causes the substitution of a stop codon (encoded by the A allele) for tryptophan(80) (encoded by the G allele) (c. 240G>A, p.Trp80stop, referred to herein as SNP W80X). Association analysis showed significant differences in subcutaneous fat colour and beta-carotene concentration amongst cattle with different BCO2 genotypes...
June 2010: Animal Genetics
#40
JOURNAL ARTICLE
Christopher J Mutrie, Shady M Eldaif, Grace D Rozycki, Edward P Chen, Cullen D Morris
The incidence of penetrating trauma to the brachiocephalic artery and aortic arch is not known, because most patients die of hemorrhage before they receive adequate treatment. Furthermore, when torrential hemorrhage from penetrating trauma is present, the anatomy of the thoracic vasculature can present a challenge for gaining adequate exposure, achieving vascular control, and performing proper repair. We describe the case of a patient with a gunshot wound to the anterior chest; he was placed under cardiopulmonary bypass and deep hypothermic circulatory arrest while we performed a patch repair of the proximal brachiocephalic artery and aortic arch...
2009: Texas Heart Institute Journal
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