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Tal Frolinger, Funda Korkmaz, Steven Sims, Fazilet Sen, Farhath Sultana, Victoria Laurencin, Liam Cullen, Anusha Rani Pallapati, Avi Liu, Satish Rojekar, Georgii Pevnev, Uliana Cheliadinova, Darya Vasilyeva, Guzel Burganova, Anne Macdonald, Mansi Saxena, Ki Goosens, Clifford Rosen, Orly Barak, Daria Lizneva, Anisa Gumerova, Keqiang Ye, Vitaly Ryu, Tony Yuen, Mone Zaidi
Alzheimer's disease (AD) is a major progressive neurodegenerative disorder of the aging population. High post-menopausal levels of the pituitary gonadotropin follicle-stimulating hormone (FSH) are strongly associated with the onset of AD, and we have shown recently that FSH directly activates the hippocampal Fshr to drive AD-like pathology and memory loss in mice. To establish a role for FSH in memory loss, we used female 3xTg;Fshr +/+ , 3xTg;Fshr +/- and 3xTg;Fshr -/- mice that were either left unoperated or underwent sham surgery or ovariectomy at 8 weeks of age...
February 29, 2024: Research Square
#2
JOURNAL ARTICLE
Ryan Williams, Aimee Morris, Veenu Gupta, Ed Penington, Alexis E Cullen, Alan Quirk, Paul French, Belinda Lennox, Alex Bottle, Mike J Crawford
BACKGROUND: The components of care delivered by Early Intervention in Psychosis (EIP) services vary, but the impact on patient experience is unknown. OBJECTIVE: To investigate associations between components of care provided by EIP services in England and patient-reported outcomes. METHODS: 2374 patients from EIP services in England were surveyed during the National Clinical Audit of Psychosis. Participants were asked about the care they received, and completed the 'Patient Global Impressions' Scale (rating whether their mental health had improved), and 'Friends and Family Test' (rating whether they would recommend their service)...
August 2023: BMJ Ment Health
#3
JOURNAL ARTICLE
Jacob H Elnaggar, Victoria O Huynh, Daniel Lin, R Tyler Hillman, Chike O Abana, Molly B El Alam, Katarina C Tomasic, Tatiana V Karpinets, Ramez Kouzy, Jae L Phan, Jennifer Wargo, Emma B Holliday, Prajnan Das, Melissa P Mezzari, Nadim J Ajami, Erica J Lynn, Bruce D Minsky, Van K Morris, Andrea Milbourne, Craig A Messick, Ann H Klopp, P Andrew Futreal, Cullen M Taniguchi, Kathleen M Schmeler, Lauren E Colbert
BACKGROUND: Squamous cell carcinoma of the anus (SCCA) is a rare gastrointestinal cancer. Factors associated with progression of HPV infection to anal dysplasia and cancer are unclear and screening guidelines and approaches for anal dysplasia are less clear than for cervical dysplasia. One potential contributing factor is the anorectal microbiome. In this study, we aimed to identify differences in anal microbiome composition in the settings of HPV infection, anal dysplasia, and anal cancer in this rare disease...
2023: Frontiers in Immunology
#4
JOURNAL ARTICLE
Sharia Hernandez, Prajnan Das, Emma B Holliday, Li Shen, Wei Lu, Benny Johnson, Craig A Messick, Cullen M Taniguchi, John Skibber, Ethan B Ludmir, Y Nancy You, Grace Li Smith, Brian Bednarski, Larisa Kostousov, Eugene J Koay, Bruce D Minsky, Matthew Tillman, Shaelynn Portier, Cathy Eng, Albert C Koong, George J Chang, Wai Chin Foo, Jing Wang, Luisa Solis Soto, Van K Morris
The identification of transcriptomic and protein biomarkers prognosticating recurrence risk after chemoradiation of localized squamous cell carcinoma of the anus (SCCA) has been limited by a lack of available fresh tissue at initial presentation. We analyzed archival FFPE SCCA specimens from pretreatment biopsies prior to chemoradiation for protein and RNA biomarkers from patients with localized SCCA who recurred (N = 23) and who did not recur (N = 25). Tumor cells and the tumor microenvironment (TME) were analyzed separately to identify biomarkers with significantly different expression between the recurrent and non-recurrent groups...
March 10, 2023: Cancers
#5
JOURNAL ARTICLE
Aviva S Mattingly, Hyrum S Eddington, Liam Rose, Arden M Morris, Amber W Trickey, Mark R Cullen, Sherry M Wren
No abstract text is available yet for this article.
October 19, 2022: JAMA Surgery
#6
JOURNAL ARTICLE
Kelsey L Corrigan, Michael K Rooney, Brian De, Ethan D Ludmir, Prajnan Das, Grace L Smith, Cullen Taniguchi, Bruce D Minsky, Eugene J Koay, Albert Koong, Van K Morris, Craig A Messick, Graciela Nogueras-Gonzalez, Emma B Holliday
PURPOSE: Pelvic chemoradiation can have a profound effect on sexual function. Few data exist describing long-term sexual function patient-reported outcomes (PROs) for patients treated with intensity modulated radiation and concurrent chemotherapy (CRT) for squamous cell carcinoma of the anus (SCCA). METHODS AND MATERIALS: We identified 248 patients with SCCA treated with CRT from 2010 to 2018 who were alive and without recurrence. We sent a PRO survey to 148 patients who agreed to participate...
September 2022: Practical Radiation Oncology
#7
JOURNAL ARTICLE
Brian De, Kelsey L Corrigan, Michael K Rooney, Ethan B Ludmir, Prajnan Das, Grace L Smith, Cullen M Taniguchi, Bruce D Minsky, Eugene J Koay, Albert Koong, Van K Morris, Craig A Messick, Y Nancy You, George J Chang, O Lenaine Westney, Graciela M Nogueras Gonzalez, Emma B Holliday
PURPOSE: Definitive radiation therapy with concurrent chemotherapy is curative for nonmetastatic squamous cell carcinoma of the anus (SCCA). However, the true effect of chemoradiation on long-term functional outcomes is poorly understood owing to limited follow-up and patient-reported outcomes (PROs). METHODS AND MATERIALS: We conducted a cross-sectional survey of 248 patients with SCCA treated with definitive intensity modulated radiation and concurrent chemotherapy from 2010 to 2018 who were alive and without recurrence...
September 1, 2022: International Journal of Radiation Oncology, Biology, Physics
#8
JOURNAL ARTICLE
Daniel Lin, Molly B El Alam, Joseph Abi Jaoude, Ramez Kouzy, Jae L Phan, Jacob H Elnaggar, Brianna Resendiz, Andrea Y Delgado Medrano, Erica J Lynn, Nicholas D Nguyen, Sonal S Noticewala, Geena G Mathew, Emma B Holliday, Bruce D Minsky, Prajnan Das, Van K Morris, Cathy Eng, Melissa P Mezzari, Joseph F Petrosino, Nadim J Ajami, Ann H Klopp, Cullen M Taniguchi, Lauren E Colbert
PURPOSE: Patients with localized squamous cell carcinoma of the anus (SCCA) who experience treatment toxicity or recurrences have few therapeutic options. Investigation into the microbiome's influence on treatment toxicity and its potential use as a predictive biomarker could improve these patients' outcomes. Our study presents the first longitudinal characterization of the SCCA tumor microbiome and its associations with treatment-related toxicities. METHODS AND MATERIALS: This prospective cohort study included patients with nonmetastatic SCCA receiving standard-of-care chemoradiation therapy...
May 2, 2022: International Journal of Radiation Oncology, Biology, Physics
#9
JOURNAL ARTICLE
Mingjin Cui, Chunpeng Yang, Sooyeon Hwang, Menghao Yang, Sean Overa, Qi Dong, Yonggang Yao, Alexandra H Brozena, David A Cullen, Miaofang Chi, Thomas F Blum, David Morris, Zou Finfrock, Xizheng Wang, Peng Zhang, Vitaliy G Goncharov, Xiaofeng Guo, Jian Luo, Yifei Mo, Feng Jiao, Liangbing Hu
Nanoscale multi-principal element intermetallics (MPEIs) may provide a broad and tunable compositional space of active, high-surface area materials with potential applications such as catalysis and magnetics. However, MPEI nanoparticles are challenging to fabricate because of the tendency of the particles to grow/agglomerate or phase-separated during annealing. Here, we demonstrate a disorder-to-order phase transition approach that enables the synthesis of ultrasmall (4 to 5 nm) and stable MPEI nanoparticles (up to eight elements)...
January 28, 2022: Science Advances
#10
JOURNAL ARTICLE
Aviva S Mattingly, Liam Rose, Hyrum S Eddington, Amber W Trickey, Mark R Cullen, Arden M Morris, Sherry M Wren
IMPORTANCE: The COVID-19 pandemic has affected every aspect of medical care, including surgical treatment. It is critical to understand the association of government policies and infection burden with surgical access across the United States. OBJECTIVE: To describe the change in surgical procedure volume in the US after the government-suggested shutdown and subsequent peak surge in volume of patients with COVID-19. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study was conducted using administrative claims from a nationwide health care technology clearinghouse...
December 1, 2021: JAMA Network Open
#11
JOURNAL ARTICLE
J Trent Magruder, Cullen Morris, Vinod H Thourani
No abstract text is available yet for this article.
November 25, 2021: Annals of Thoracic Surgery
#12
JOURNAL ARTICLE
Nicolette Taku, Y Nancy Yi-Qian, George J Chang, Ethan B Ludmir, Kanwal Pratap Singh Raghav, Miguel A Rodriguez-Bigas, Emma Brey Holliday, Grace L Smith, Bruce D Minsky, Michael J Overman, Craig Messick, David Boyce-Fappiano, Albert C Koong, John Michael Skibber, Eugene Jon Koay, Arvind Dasari, Cullen M Taniguchi, Brian K Bednarski, Van K Morris, Scott Kopetz, Prajnan Das
PURPOSE: There has been an increase in the incidence of rectal cancer diagnosed in young adults (age < 50 years). We evaluated outcomes among young adults treated with pre-operative long course chemoradiation (CRT) and total mesorectal excision (TME). METHODS: The medical records of 219 patients, age 18-49, with non-metastatic, cT3-4, or cN1-2 rectal adenocarcinoma treated from 2000 to 2017 were reviewed for demographic and treatment characteristics, as well as pathologic and oncologic outcomes...
October 9, 2021: Clinical Colorectal Cancer
#13
JOURNAL ARTICLE
Brian De, Ethan B Ludmir, Craig A Messick, Matthew C Cagley, Van K Morris, Prajnan Das, Bruce D Minsky, Cullen M Taniguchi, Grace L Smith, Eugene J Koay, Albert C Koong, Radhe Mohan, Emma B Holliday
Background: Outcomes after definitive chemoradiation for squamous cell carcinoma are generally favorable. However, biomarkers to further yield prognostic information are desired. Treatment-related lymphopenia as well as an elevated baseline neutrophil-lymphocyte ratio have been associated with worse survival in several cancer types. We evaluated absolute lymphocyte count and neutrophil-lymphocyte ratio at baseline and at treatment-related nadir in patients with anal cancer for associations with oncologic endpoints...
October 2021: Journal of Gastrointestinal Oncology
#14
JOURNAL ARTICLE
Robert Hester, Shailesh Advani, Asif Rashid, Emma Holliday, Craig Messick, Prajnan Das, Yi-Qian N You, Cullen Taniguchi, Eugene J Koay, Brian Bednarski, Miguel Rodriguez-Bigas, John Skibber, Robert Wolff, George J Chang, Bruce D Minsky, Wai Chin Foo, Nicole Rothschild, Van K Morris, Cathy Eng
BACKGROUND: The clinical utility of a blood-based biomarker in squamous cell carcinoma of the anus (SCCA) is unknown. We analyzed carcinoembryonic antigen (CEA), a commonly employed assay for patients with colorectal adenocarcinoma, as a serum biomarker for patients with biopsy-proven SCCA. MATERIALS AND METHODS: Medical records from 219 patients with biopsy-proven SCCA at the University of Texas MD Anderson Cancer Center were reviewed under an IRB-approved protocol from 2013 to 2020 to assess for correlations between CEA levels and corresponding clinical and pathologic characteristics...
May 25, 2021: Oncotarget
#15
JOURNAL ARTICLE
Julia Morris, Soddy Sau Yu Leung, Mark E S Bailey, Breda Cullen, Amy Ferguson, Nicholas Graham, Keira J A Johnston, Donald M Lyall, Laura M Lyall, Joey Ward, Daniel J Smith, Rona J Strawbridge
Individuals with severe mental illness have an increased risk of cardiometabolic diseases compared to the general population. Shared risk factors and medication effects explain part of this excess risk; however, there is growing evidence to suggest that shared biology (including genetic variation) is likely to contribute to comorbidity between mental and physical illness. Contactins are a family of genes involved in development of the nervous system and implicated, though genome-wide association studies, in a wide range of psychological, psychiatric and cardiometabolic conditions...
November 10, 2020: Genes
#16
JOURNAL ARTICLE
Karolina I Rokita, Maria R Dauvermann, David Mothersill, Laurena Holleran, Jessica Holland, Laura Costello, Caroline Cullen, Ruán Kane, Declan McKernan, Derek W Morris, John Kelly, Michael Gill, Aiden Corvin, Brian Hallahan, Colm McDonald, Gary Donohoe
OBJECTIVE: This study investigated associations between childhood trauma, parental bonding, and social cognition (i.e., Theory of Mind and emotion recognition) in patients with schizophrenia and healthy adults. METHODS: Using cross-sectional data, we examined the recollections of childhood trauma experiences and social cognitive abilities in 74 patients with schizophrenia and 116 healthy adults. RESULTS: Patients had significantly higher scores compared with healthy participants on childhood trauma, and lower scores on parental bonding and social cognitive measures...
August 12, 2020: Journal of Clinical Psychology
#17
JOURNAL ARTICLE
Jakub Lagan Lekarz, Josephine H Naish, Kara Simpson, Min Zi, Elizabeth J Cartwright, Phil Foden, Julie Morris, David Clark, Lindsay Birchall, Jessica Caldwell, Andrew Trafford, Christien Fortune, Michael Cullen, Nazia Chaudhuri, James Fildes, Jaydeep Sarma, Erik B Schelbert, Matthias Schmitt, Karen Piper Hanley, Christopher A Miller
OBJECTIVES: The purpose of this study was to identify where ultrasmall superparamagnetic particles of iron oxide (USPIO) locate to in myocardium, develop a methodology that differentiates active macrophage uptake of USPIO from passive tissue distribution; and investigate myocardial inflammation in cardiovascular diseases. BACKGROUND: Myocardial inflammation is hypothesized to be a key pathophysiological mechanism of heart failure (HF), but human evidence is limited, partly because evaluation is challenging...
April 10, 2020: JACC. Cardiovascular Imaging
#18
MULTICENTER STUDY
Johannes T Neumann, Raphael Twerenbold, Francisco Ojeda, Nils A Sörensen, Andrew R Chapman, Anoop S V Shah, Atul Anand, Jasper Boeddinghaus, Thomas Nestelberger, Patrick Badertscher, Arash Mokhtari, John W Pickering, Richard W Troughton, Jaimi Greenslade, William Parsonage, Matthias Mueller-Hennessen, Tommaso Gori, Tomas Jernberg, Niall Morris, Christoph Liebetrau, Christian Hamm, Hugo A Katus, Thomas Münzel, Ulf Landmesser, Veikko Salomaa, Licia Iacoviello, Marco M Ferrario, Simona Giampaoli, Frank Kee, Barbara Thorand, Annette Peters, Rossana Borchini, Torben Jørgensen, Stefan Söderberg, Susana Sans, Hugh Tunstall-Pedoe, Kari Kuulasmaa, Thomas Renné, Karl J Lackner, Andrew Worster, Richard Body, Ulf Ekelund, Peter A Kavsak, Till Keller, Bertil Lindahl, Philipp Wild, Evangelos Giannitsis, Martin Than, Louise A Cullen, Nicholas L Mills, Christian Mueller, Tanja Zeller, Dirk Westermann, Stefan Blankenberg
BACKGROUND: Data regarding high-sensitivity troponin concentrations in patients presenting to the emergency department with symptoms suggestive of myocardial infarction may be useful in determining the probability of myocardial infarction and subsequent 30-day outcomes. METHODS: In 15 international cohorts of patients presenting to the emergency department with symptoms suggestive of myocardial infarction, we determined the concentrations of high-sensitivity troponin I or high-sensitivity troponin T at presentation and after early or late serial sampling...
June 27, 2019: New England Journal of Medicine
#19
JOURNAL ARTICLE
Dorota A Jarret, Jenny Morris, Danny W Cullen, Sandra L Gordon, Susan R Verrall, Linda Milne, Pete E Hedley, J William Allwood, Rex M Brennan, Robert D Hancock
Blackcurrant fruit collected at six stages of development were assessed for changes in gene expression using custom whole transcriptome microarrays and for variation in metabolite content using a combination of liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry. Principal components analysis demonstrated that fruit development could be clearly defined according to their transcript or metabolite profiles. During early developmental stages, metabolite profiles were dominated by amino acids and tannins, whilst transcript profiles were enriched in functions associated with cell division, anatomical structure morphogenesis and cell wall metabolism...
2018: Frontiers in Plant Science
#20
JOURNAL ARTICLE
Hannah Dickson, Alexis E Cullen, Rebecca Jones, Abraham Reichenberg, Ruth E Roberts, Sheilagh Hodgins, Robin G Morris, Kristin R Laurens
BACKGROUND: Among adults with schizophrenia, evidence suggests that premorbid deficits in different cognitive domains follow distinct developmental courses during childhood and adolescence. The aim of this study was to delineate trajectories of adolescent cognitive functions prospectively among different groups of youth at-risk for schizophrenia, relative to their typically developing (TD) peers. METHOD: Using linear mixed models adjusted for sex, ethnicity, parental occupation and practice effects, cognitive development between ages 9 and 16 years was compared for youth characterised by a triad of well-replicated developmental antecedents of schizophrenia (ASz; N = 32) and youth with a least one affected relative with schizophrenia or schizoaffective disorder (FHx; N = 29), relative to TD youth (N = 45)...
April 23, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
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