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Hui Wang, Timothy S Chang, Beth A Dombroski, Po-Liang Cheng, Ya-Qin Si, Albert Tucci, Vishakha Patil, Leopoldo Valiente-Banuet, Kurt Farrell, Catriona Mclean, Laura Molina-Porcel, Rajput Alex, Peter Paul De Deyn, Nathalie Le Bastard, Marla Gearing, Laura Donker Kaat, John C Van Swieten, Elise Dopper, Bernardino F Ghetti, Kathy L Newell, Claire Troakes, Justo G de Yébenes, Alberto Rábano-Gutierrez, Tina Meller, Wolfgang H Oertel, Gesine Respondek, Maria Stamelou, Thomas Arzberger, Sigrun Roeber, Ulrich Müller, Franziska Hopfner, Pau Pastor, Alexis Brice, Alexandra Durr, Isabelle Le Ber, Thomas G Beach, Geidy E Serrano, Lili-Naz Hazrati, Irene Litvan, Rosa Rademakers, Owen A Ross, Douglas Galasko, Adam L Boxer, Bruce L Miller, Willian W Seeley, Vivianna M Van Deerlin, Edward B Lee, Charles L White, Huw R Morris, Rohan de Silva, John F Crary, Alison M Goate, Jeffrey S Friedman, Yuk Yee Leung, Giovanni Coppola, Adam C Naj, Li-San Wang, Dennis W Dickson, Günter U Höglinger, Jung-Ying Tzeng, Daniel H Geschwind, Gerard D Schellenberg, Wan-Ping Lee
IMPORTANCE: The chromosome 17q21.31 region, containing a 900 Kb inversion that defines H1 and H2 haplotypes, represents the strongest genetic risk locus in progressive supranuclear palsy (PSP). In addition to H1 and H2, various structural forms of 17q21.31, characterized by the copy number of α, β, and γ duplications, have been identified. However, the specific effect of each structural form on the risk of PSP has never been evaluated in a large cohort study. OBJECTIVE: To assess the association of different structural forms of 17q...
February 28, 2024: medRxiv
#22
JOURNAL ARTICLE
Paul T Kopp, Catherine Yang, Heidi Yang, Jeffrey N Katz, A David Paltiel, David J Hunter, Leigh F Callahan, Shannon L Mihalko, Jovita J Newman, Paul DeVita, Richard F Loeser, Gary D Miller, Stephen P Messier, Elena Losina
BACKGROUND: Obesity exacerbates pain and functional limitation in persons with knee osteoarthritis (OA). In the Weight Loss and Exercise for Communities with Arthritis in North Carolina (WE-CAN) study, a community-based diet and exercise (D+E) intervention led to an additional 6kg weight loss and 20% greater pain relief in persons with knee OA and BMI>27 kg/m2 relative to a group-based health education (HE) intervention. We sought to determine the incremental cost-effectiveness of the Usual Care (UC), UC+HE, and UC+(D+E) programs, comparing each strategy to the 'next-best' strategy, ranked by increasing lifetime cost...
March 7, 2024: Arthritis Care & Research
#23
JOURNAL ARTICLE
Nicholas A Zorko, Allison Makovec, Andrew Elliott, Samuel Kellen, John R Lozada, Ali T Arafa, Martin Felices, Madison Shackelford, Pedro Barata, Yousef Zakharia, Vivek Narayan, Mark N Stein, Kevin K Zarrabi, Akash Patniak, Mehmet A Bilen, Milan Radovich, George Sledge, Wafik S El-Deiry, Elisabeth I Heath, Dave S B Hoon, Chadi Nabhan, Jeffrey S Miller, Justin H Hwang, Emmanuel S Antonarakis
BACKGROUND: Natural killer (NK) cells are non-antigen specific innate immune cells that can be redirected to targets of interest using multiple strategies, although none are currently FDA-approved. We sought to evaluate NK cell infiltration into tumors to develop an improved understanding of which histologies may be most amenable to NK cell-based therapies currently in the developmental pipeline. METHODS: DNA (targeted/whole-exome) and RNA (whole-transcriptome) sequencing was performed from tumors from 45 cancer types (N = 90,916 for all cancers and N = 3365 for prostate cancer) submitted to Caris Life Sciences...
February 28, 2024: Prostate Cancer and Prostatic Diseases
#24
JOURNAL ARTICLE
Antonella Zanobetti, Patrick H Ryan, Brent A Coull, Heike Luttmann-Gibson, Soma Datta, Jeffrey Blossom, Cole Brokamp, Nathan Lothrop, Rachel L Miller, Paloma I Beamer, Cynthia M Visness, Howard Andrews, Leonard B Bacharier, Tina Hartert, Christine C Johnson, Dennis R Ownby, Gurjit K Khurana Hershey, Christine L M Joseph, Eneida A Mendonça, Daniel J Jackson, Edward M Zoratti, Anne L Wright, Fernando D Martinez, Christine M Seroogy, Sima K Ramratnam, Agustin Calatroni, James E Gern, Diane R Gold
IMPORTANCE: Exposure to outdoor air pollution contributes to childhood asthma development, but many studies lack the geographic, racial and ethnic, and socioeconomic diversity to evaluate susceptibility by individual-level and community-level contextual factors. OBJECTIVE: To examine early life exposure to fine particulate matter (PM2.5) and nitrogen oxide (NO2) air pollution and asthma risk by early and middle childhood, and whether individual and community-level characteristics modify associations between air pollution exposure and asthma...
February 5, 2024: JAMA Network Open
#25
JOURNAL ARTICLE
Naomi Shek, Anna-Maria Choy, Chim C Lang, Bruce E Miller, Ruth Tal-Singer, Charlotte E Bolton, Neil C Thomson, James D Chalmers, Matt J Bown, David E Newby, Faisel Khan, Jeffrey T J Huang
Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.
February 27, 2024: NPJ Aging
#26
JOURNAL ARTICLE
Mohamad Abdalkader, Matthew I Miller, Piers Klein, Ferdinand K Hui, Jeffrey J Siracuse, Asim Z Mian, Osamu Sakai, Thanh N Nguyen, Bindu N Setty
OBJECTIVE: Internal Jugular Vein Stenosis (IJVS) is hypothesized to play a role in the pathogenesis of diverse neurological diseases. We sought to evaluate differences in IJVS assessment between CT and MRI in a retrospective patient cohort. METHODS: We included consecutive patients who had both MRI of the brain and CT of the head and neck with contrast from 1 June 2021 to 30 June 2022 within the same admission. The degree of IJVS was categorized into five grades (0-IV)...
February 11, 2024: Tomography: a Journal for Imaging Research
#27
JOURNAL ARTICLE
Whitney M Davidson, Anika Mahavni, Timothy Chrusciel, Joanne Salas, Lisa R Miller-Matero, Mark D Sullivan, Celeste Zabel, Patrick J Lustman, Brian K Ahmedani, Jeffrey F Scherrer
OBJECTIVE: Marijuana use is increasingly common among patients with chronic non-cancer pain (CNCP) and long-term opioid therapy (LTOT). We determined if lifetime recreational and medical marijuana use were associated with more frequent and higher dose prescription opioid use. DESIGN: Cross-sectional SUBJECTS: Eligible patients (n=1,037), who had a new period of prescription opioid use lasting 30-90 days, were recruited from two midwestern health care systems to a study of long-term prescription opioid use and mental health outcomes...
February 22, 2024: Journal of cannabis research
#28
JOURNAL ARTICLE
Jasmine M Miller-Kleinhenz, Lauren E Barber, Maret L Maliniak, Leah Moubadder, Maya Bliss, Micah J Streiff, Jeffrey M Switchenko, Kevin C Ward, Lauren E McCullough
IMPORTANCE: Inequities created by historical and contemporary mortgage discriminatory policies have implications for health disparities. The role of persistent mortgage discrimination (PMD) in breast cancer (BC) outcomes has not been studied. OBJECTIVE: To estimate the race-specific association of historical redlining (HRL) with the development of BC subtypes and late-stage disease and a novel measure of PMD in BC mortality. DESIGN, SETTING, AND PARTICIPANTS: This population-based cohort study used Georgia Cancer Registry data...
February 5, 2024: JAMA Network Open
#29
JOURNAL ARTICLE
Roshini S Abraham, Amrita Basu, Jennifer R Heimall, Elizabeth Dunn, Alison Yip, Malika Kapadia, Neena Kapoor, Lisa Forbes Satter, Rebecca Buckley, Richard O'Reilly, Geoffrey D E Cuvelier, Sharat Chandra, Jeffrey Bednarski, Sonali Chaudhury, Theodore B Moore, Hilary Haines, Blachy J Dávila Saldaña, Deepakbabu Chellapandian, Ahmad Rayes, Karin Chen, Emi Caywood, Shanmuganathan Chandrakasan, Mark Thomas Vander Lugt, Christen Ebens, Pierre Teira, Evan Shereck, Holly Miller, Victor Aquino, Hesham Eissa, Lolie C Yu, Alfred Gillio, Lisa Madden, Alan Knutsen, Ami J Shah, Kenneth DeSantes, Jessie Barnum, Larisa Broglie, Avni Y Joshi, Gary Kleiner, Jasmeen Dara, Susan Prockop, Caridad Martinez, Talal Mousallem, Joseph Oved, Lauri Burroughs, Rebecca Marsh, Troy R Torgerson, Jennifer W Leiding, Sung Yun Pai, Donald B Kohn, Michael A Pulsipher, Linda M Griffith, Luigi D Notarangelo, Morton J Cowan, Jennifer Puck, Christopher C Dvorak, Elie Haddad
Severe combined immunodeficiency (SCID) is characterized by a severe deficiency in T cell numbers. We analyzed data collected (n = 307) for PHA-based T cell proliferation from the PIDTC SCID protocol 6901, using either a radioactive or flow cytometry method. In comparing the two groups, a smaller number of the patients tested by flow cytometry had <10% of the lower limit of normal proliferation as compared to the radioactive method (p = 0.02). Further, in patients with CD3+ T cell counts between 51 and 300 cells/μL, there was a higher proliferative response with the PHA flow assay compared to the 3 H-T assay (p < 0...
February 15, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
#30
JOURNAL ARTICLE
Friedrich Fauser, Bhakti N Kadam, Sebastian Arangundy-Franklin, Jessica E Davis, Vishvesha Vaidya, Nicola J Schmidt, Garrett Lew, Danny F Xia, Rakshaa Mureli, Colman Ng, Yuanyue Zhou, Nicholas A Scarlott, Jason Eshleman, Yuri R Bendaña, David A Shivak, Andreas Reik, Patrick Li, Gregory D Davis, Jeffrey C Miller
Nucleobase editors represent an emerging technology that enables precise single-base edits to the genomes of eukaryotic cells. Most nucleobase editors use deaminase domains that act upon single-stranded DNA and require RNA-guided proteins such as Cas9 to unwind the DNA prior to editing. However, the most recent class of base editors utilizes a deaminase domain, DddAtox , that can act upon double-stranded DNA. Here, we target DddAtox fragments and a FokI-based nickase to the human CIITA gene by fusing these domains to arrays of engineered zinc fingers (ZFs)...
February 15, 2024: Nature Communications
#31
JOURNAL ARTICLE
Alexandra M Huddell, Resham Thapa, Guillermo S Marcillo, Lori J Abendroth, Victoria J Ackroyd, Shalamar D Armstrong, Gautam Asmita, Muthukumar V Bagavathiannan, Kipling S Balkcom, Andrea Basche, Shawn Beam, Kevin Bradley, Lucas Pecci Canisares, Heather Darby, Adam S Davis, Pratap Devkota, Warren A Dick, Jeffery A Evans, Wesley J Everman, Tauana Ferreira de Almeida, Michael L Flessner, Lisa M Fultz, Stefan Gailans, Masoud Hashemi, Joseph Haymaker, Matthew J Helmers, Nicholas Jordan, Thomas C Kaspar, Quirine M Ketterings, Eileen Kladivko, Alexandra Kravchenko, Eugene P Law, Lauren Lazaro, Ramon G Leon, Jeffrey Liebert, John Lindquist, Kristen Loria, Jodie M McVane, Jarrod O Miller, Michael J Mulvaney, Nsalambi V Nkongolo, Jason K Norsworthy, Binaya Parajuli, Christopher Pelzer, Cara Peterson, Hanna Poffenbarger, Pratima Poudel, Mark S Reiter, Matt Ruark, Matthew R Ryan, Spencer Samuelson, John E Sawyer, Sarah Seehaver, Lovreet S Shergill, Yogendra Raj Upadhyaya, Mark VanGessel, Ashley L Waggoner, John M Wallace, Samantha Wells, Charles White, Bethany Wolters, Alex Woodley, Rongzhong Ye, Eric Youngerman, Brian A Needelman, Steven B Mirsky
Winter cover crop performance metrics (i.e., vegetative biomass quantity and quality) affect ecosystem services provisions, but they vary widely due to differences in agronomic practices, soil properties, and climate. Cereal rye (Secale cereale) is the most common winter cover crop in the United States due to its winter hardiness, low seed cost, and high biomass production. We compiled data on cereal rye winter cover crop performance metrics, agronomic practices, and soil properties across the eastern half of the United States...
February 13, 2024: Scientific Data
#32
JOURNAL ARTICLE
Kathryn E Hitchcock, Eric D Miller, Qian Shi, Jesse G Dixon, Sepideh Gholami, Sarah B White, Christina Wu, Christopher C Goulet, Manju George, Kyung-Wook Jee, Chadwick L Wright, Rona Yaeger, Ardaman Shergill, Theodore S Hong, Thomas J George, Eileen M O'Reilly, Jeffrey A Meyerhardt, Paul B Romesser
BACKGROUND: For patients with liver-confined metastatic colorectal cancer (mCRC), local therapy of isolated metastases has been associated with long-term progression-free and overall survival (OS). However, for patients with more advanced mCRC, including those with extrahepatic disease, the efficacy of local therapy is less clear although increasingly being used in clinical practice. Prospective studies to clarify the role of metastatic-directed therapies in patients with mCRC are needed...
February 13, 2024: BMC Cancer
#33
EDITORIAL
Jeffrey Cl Looi, Andrew Amos, Samantha Loi, Tarun Bastiampillai, Sharon Reutens, Luke Woon, Paul A Maguire, Steve Kisely, Edward Miller, Ahnoor Benipal, Fiona Wilkes
No abstract text is available yet for this article.
April 2024: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
#34
JOURNAL ARTICLE
Celestia S Higano, Sabina Dizdarevic, John Logue, Timothy Richardson, Saby George, Igle de Jong, Jeffrey J Tomaszewski, Fred Saad, Kurt Miller, Jeffrey Meltzer, Per Sandström, Frank Verholen, Bertrand Tombal, Oliver Sartor
BACKGROUND: Radium-223 and taxane chemotherapy each improve survival of patients with metastatic castration-resistant prostate cancer (mCRPC). Whether the radium-223-taxane sequence could extend survival without cumulative toxicity was explored. METHODS: The global, prospective, observational REASSURE study (NCT02141438) assessed real-world safety and effectiveness of radium-223 in patients with mCRPC. Using data from the prespecified second interim analysis (data cutoff, March 20, 2019), hematologic events and overall survival (OS) were evaluated in patients who were chemotherapy-naive at radium-223 initiation and subsequently received taxane chemotherapy starting ≤90 days ("immediate") or >90 days ("delayed") after the last radium-223 dose...
February 10, 2024: Cancer
#35
JOURNAL ARTICLE
Ryotaro Nakamura, Corinna La Rosa, Dongyun Yang, Joshua A Hill, Armin Rashidi, Hannah Choe, Qiao Zhou, Chetan Raj Lingaraju, Teodora Kaltcheva, Jeffrey Longmate, Jennifer Drake, Cynthia Slape, Lupe Duarte, Monzr M Al Malki, Vinod A Pullarkat, Ahmed Aribi, Steven Devine, Michael R Verneris, Jeffrey S Miller, Stephen J Forman, Ibrahim Aldoss, Don J Diamond
Not available.
February 8, 2024: Haematologica
#36
JOURNAL ARTICLE
Martha Catalina Morales-Alvarez, Voravech Nissaisorakarn, Lawrence J Appel, Edgar R Miller, Robert Christenson, Heather Rebuck, Sylvia E Rosas, Jeffrey H William, Stephen P Juraschek
INTRODUCTION: A potassium-rich DASH diet combined with low sodium reduces blood pressure. However, the effects of sodium reduction in combination with the DASH diet on kidney function are unknown. We aimed to determine the effects of sodium reduction and the DASH diet, on estimated glomerular filtration rate (eGFR) by cystatin C. METHODS: DASH-Sodium was a controlled, feeding study in adults with elevated or stage 1 hypertension, randomly assigned to the DASH or a control diet...
February 8, 2024: Kidney360
#37
JOURNAL ARTICLE
Ashley F P Sanders, Brian Tirado, Nicole A Seider, Regina L Triplett, Rachel E Lean, Jeffrey J Neil, J Philip Miller, Rebecca Tillman, Tara A Smyser, Deanna M Barch, Joan L Luby, Cynthia E Rogers, Christopher D Smyser, Barbara B Warner, Edith Chen, Gregory E Miller
Prenatal exposure to heightened maternal inflammation has been associated with adverse neurodevelopmental outcomes, including atypical brain maturation and psychiatric illness. In mothers experiencing socioeconomic disadvantage, immune activation can be a product of the chronic stress inherent to such environmental hardship. While growing preclinical and clinical evidence has shown links between altered neonatal brain development and increased inflammatory states in utero, the potential mechanism by which socioeconomic disadvantage differentially impacts neural-immune crosstalk remains unclear...
February 2, 2024: Translational Psychiatry
#38
JOURNAL ARTICLE
Jack K Donohue, Danielle S Gruen, Nidhi Iyanna, John M Lorence, Joshua B Brown, Francis X Guyette, Brian J Daley, Brian J Eastridge, Richard S Miller, Raminder Nirula, Brian G Harbrecht, Jeffrey A Claridge, Herb A Phelan, Gary A Vercruysse, Terence O'Keeffe, Bellal Joseph, Matthew D Neal, Timothy R Billiar, Jason L Sperry
Injury mechanism is an important consideration when conducting clinical trials in trauma. Mechanisms of injury may be associated with differences in mortality risk and immune response to injury, impacting the potential success of the trial. We sought to characterize clinical and endothelial cell damage marker differences across blunt and penetrating injured patients enrolled in three large, prehospital randomized trials which focused on hemorrhagic shock. In this secondary analysis, patients with systolic blood pressure < 70 or systolic blood pressure < 90 and heart rate > 108 were included...
February 2, 2024: Scientific Reports
#39
JOURNAL ARTICLE
Zachary P Wallace, Bryan E Bedrosian, Jeffrey R Dunk, David W LaPlante, Brian Woodbridge, Brian W Smith, Jessi L Brown, Todd M Lickfett, Katherine Gura, Dave Bittner, Ross H Crandall, Rob Domenech, Todd E Katzner, Kevin J Kritz, Stephen B Lewis, Michael J Lockhart, Tricia A Miller, Katie Quint, Adam Shreading, Steve J Slater, Dale W Stahlecker
Wildlife conservation strategies focused on one season or population segment may fail to adequately protect populations, especially when a species' habitat preferences vary among seasons, age-classes, geographic regions, or other factors. Conservation of golden eagles (Aquila chrysaetos) is an example of such a complex scenario, in which the distribution, habitat use, and migratory strategies of this species of conservation concern vary by age-class, reproductive status, region, and season. Nonetheless, research aimed at mapping priority use areas to inform management of golden eagles in western North America has typically focused on territory-holding adults during the breeding period, largely to the exclusion of other seasons and life-history groups...
2024: PloS One
#40
JOURNAL ARTICLE
Jeffrey T Miller, Bryan W Clark, Noah M Reid, Sibel I Karchner, Jennifer L Roach, Mark E Hahn, Diane Nacci, Andrew Whitehead
The genetic architecture of phenotypic traits can affect the mode and tempo of trait evolution. Human-altered environments can impose strong natural selection, where successful evolutionary adaptation requires swift and large phenotypic shifts. In these scenarios, theory predicts that adaptation is due to a few adaptive variants of large effect, but empirical studies that have revealed the genetic architecture of rapidly evolved phenotypes are rare, especially for populations inhabiting polluted environments...
January 2024: Evolutionary Applications
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