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Jeffrey Miller

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https://www.readbyqxmd.com/read/29661902/brain-structure-and-cognition-3-years-after-the-end-of-an-early-menopausal-hormone-therapy-trial
#1
Kejal Kantarci, Nirubol Tosakulwong, Timothy G Lesnick, Samantha M Zuk, Val J Lowe, Julie A Fields, Jeffrey L Gunter, Matthew L Senjem, Megan L Settell, Carey E Gleason, Lynne T Shuster, Kent R Bailey, N Maritza Dowling, Sanjay Asthana, Clifford R Jack, Walter A Rocca, Virginia M Miller
OBJECTIVE: The effects of 2 frequently used formulations of menopausal hormone therapy (mHT) on brain structure and cognition were investigated 3 years after the end of a randomized, placebo-controlled trial in recently menopausal women with good cardiovascular health. METHODS: Participants (aged 42-56 years; 5-36 months past menopause) were randomized to one of the following: 0.45 mg/d oral conjugated equine estrogen (oCEE); 50 μg/d transdermal 17β-estradiol (tE2); or placebo pills and patch for 4 years...
April 17, 2018: Neurology
https://www.readbyqxmd.com/read/29653121/integration-and-diagnostic-accuracy-of-3t-non-endorectal-coil-prostate-mri-in-the-context-of-active-surveillance
#2
Nicole E Curci, Brian R Lane, Prasad R Shankar, Sabrina L Noyes, Andrew K Moriarty, Anthony Kubat, Chris Brede, Jeffrey S Montgomery, Gregory B Auffenberg, David C Miller, James E Montie, Arvin K George, Matthew S Davenport
OBJECTIVE: To evaluate the integration of 3T non-endorectal-coil multiparametric prostate MRI (mpMRI) at two high-volume practices that routinely use mpMRI in the setting of active surveillance. MATERIALS AND METHODS: This was an IRB-approved, HIPAA-compliant, dual-institution retrospective cohort study. Subjects undergoing 3T mpMRI without endorectal coil at either study institution over a 13-month period (8/1/2015-8/31/2016) were selected based on pre-defined criteria: clinical T1/T2 Gleason 6 prostate cancer, PSA<15 ng/mL, ≥40 years-old, mpMRI within 2 years of prostate biopsy, PI-RADS v2 score assigned...
April 10, 2018: Urology
https://www.readbyqxmd.com/read/29649369/women-with-newly-diagnosed-uterine-fibroids-treatment-patterns-and-cost-comparison-for-select-treatment-options
#3
Machaon M Bonafede, Scott K Pohlman, Jeffrey D Miller, Ellen Thiel, Kathleen A Troeger, Charles E Miller
The primary objective of this study was to describe surgical treatment patterns among women with newly diagnosed uterine fibroids (UF). A secondary objective was to estimate the medical costs associated with other common surgical interventions for UF. Claims-based commercial and Medicare data (2011-2016) were used to identify women aged ≥30 years with continuous enrollment for at least 12 months before and after a new diagnosis of UF. Receipt of a surgical or radiologic procedure (hysterectomy, myomectomy, endometrial ablation, uterine artery embolization, and curettage) was the primary outcome...
March 2018: Population Health Management
https://www.readbyqxmd.com/read/29643105/a-next-generation-sequencing-based-assay-for-minimal-residual-disease-assessment-in-aml-patients-with-flt3-itd-mutations
#4
Mark J Levis, Alexander E Perl, Jessica K Altman, Christopher D Gocke, Erkut Bahceci, Jason Hill, Chaofeng Liu, Zhiyi Xie, Andrew R Carson, Valerie McClain, Timothy T Stenzel, Jeffrey E Miller
Internal tandem duplications in fms-like tyrosine kinase 3 ( FLT3- ITDs) are common in acute myeloid leukemia (AML) and confer a poor prognosis. A sensitive and specific assay for the detection of minimal residual disease (MRD) in FLT3- ITD mutated AML could guide therapy decisions. Existing assays for MRD in FLT3- ITD AML have not been particularly useful because of limited sensitivity. We developed a sensitive and specific MRD assay for FLT3- ITD mutations using next-generation sequencing. The initial validation of this assay was performed by spiking fixed amounts of mutant DNA into wild-type DNA to establish a sensitivity of detection equivalent to ≥1 FLT3- ITD-containing cell in 10 000, with a minimum input of 100 000 cell equivalents of DNA...
April 24, 2018: Blood Advances
https://www.readbyqxmd.com/read/29628333/multidisciplinary-difficult-airway-course-an-essential-educational-component-of-a-hospital-wide-difficult-airway-response-program
#5
W Robert Leeper, Elliott R Haut, Vinciya Pandian, Sajan Nakka, Jeffrey Dodd-O, Nasir Bhatti, Elizabeth A Hunt, Mustapha Saheed, Nicholas Dalesio, Adam Schiavi, Christina Miller, Thomas D Kirsch, Lauren Berkow
OBJECTIVE: A hospital-wide difficult airway response team was developed in 2008 at The Johns Hopkins Hospital with three central pillars: operations, safety monitoring, and education. The objective of this study was to assess the outcomes of the educational pillar of the difficult airway response team program, known as the multidisciplinary difficult airway course (MDAC). DESIGN: The comprehensive, full-day MDAC involves trainees and staff from all provider groups who participate in airway management...
April 5, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29628312/alt-803-an-il-15-superagonist-in-combination-with-nivolumab-in-patients-with-metastatic-non-small-cell-lung-cancer-a-non-randomised-open-label-phase-1b-trial
#6
John M Wrangle, Vamsidhar Velcheti, Manish R Patel, Elizabeth Garrett-Mayer, Elizabeth G Hill, James G Ravenel, Jeffrey S Miller, Mohammad Farhad, Kate Anderton, Kathryn Lindsey, Michele Taffaro-Neskey, Carol Sherman, Samantha Suriano, Marzena Swiderska-Syn, Amy Sion, Joni Harris, Andie R Edwards, Julie A Rytlewski, Catherine M Sanders, Erik C Yusko, Mark D Robinson, Carsten Krieg, William L Redmond, Jack O Egan, Peter R Rhode, Emily K Jeng, Amy D Rock, Hing C Wong, Mark P Rubinstein
BACKGROUND: Immunotherapy with PD-1 or PD-L1 blockade fails to induce a response in about 80% of patients with unselected non-small cell lung cancer (NSCLC), and many of those who do initially respond then develop resistance to treatment. Agonists that target the shared interleukin-2 (IL-2) and IL-15Rβγ pathway have induced complete and durable responses in some cancers, but no studies have been done to assess the safety or efficacy of these agonists in combination with anti-PD-1 immunotherapy...
April 5, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29628068/negative-autobiographical-memory-in-depression-reflects-elevated-amygdala-hippocampal-reactivity-and-hippocampally-associated-emotion-regulation
#7
Bruce P Doré, Odile Rodrik, Chelsea Boccagno, Alexa Hubbard, Jochen Weber, Barbara Stanley, Maria A Oquendo, Jeffrey M Miller, M Elizabeth Sublette, J John Mann, Kevin N Ochsner
BACKGROUND: Dysregulated autobiographical recall is observed in major depressive disorder (MDD). However, it is unknown whether people with MDD show abnormalities in memory-, emotion-, and control-related brain systems during reactivity to and regulation of negative autobiographical memories. METHODS: We used functional magnetic resonance imaging to identify neural mechanisms underlying MDD-related emotional responses to negative autobiographical memories and the ability to downregulate these responses using a cognitive regulatory strategy known as reappraisal...
April 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29625893/interleukin-15-complex-treatment-protects-mice-from-cerebral-malaria-by-inducing-interleukin-10-producing-natural-killer-cells
#8
Kristina S Burrack, Matthew A Huggins, Emily Taras, Philip Dougherty, Christine M Henzler, Rendong Yang, Sarah Alter, Emily K Jeng, Hing C Wong, Martin Felices, Frank Cichocki, Jeffrey S Miller, Geoffrey T Hart, Aaron J Johnson, Stephen C Jameson, Sara E Hamilton
Cerebral malaria is a deadly complication of Plasmodium infection and involves blood brain barrier (BBB) disruption following infiltration of white blood cells. During experimental cerebral malaria (ECM), mice inoculated with Plasmodium berghei ANKA-infected red blood cells develop a fatal CM-like disease caused by CD8+ T cell-mediated pathology. We found that treatment with interleukin-15 complex (IL-15C) prevented ECM, whereas IL-2C treatment had no effect. IL-15C-expanded natural killer (NK) cells were necessary and sufficient for protection against ECM...
March 20, 2018: Immunity
https://www.readbyqxmd.com/read/29620686/physiological-and-functional-alterations-after-spaceflight-and-bed-rest
#9
Ajitkumar P Mulavara, Brian T Peters, Chris A Miller, Igor S Kofman, Millard F Reschke, Laura C Taylor, Emily L Lawrence, Scott J Wood, Steven S Laurie, Stuart M C Lee, Roxanne E Buxton, Tiffany R May-Phillips, Michael B Stenger, Lori L Ploutz-Snyder, Jeffrey W Ryder, Alan H Feiveson, Jacob J Bloomberg
INTRODUCTION: Exposure to microgravity causes alterations in multiple physiological systems, potentially impacting the ability of astronauts to perform critical mission tasks. The goal of this study was to determine the effects of spaceflight on functional task performance and to identify the key physiological factors contributing to their deficits. METHODS: A test battery comprised of 7 functional tests and 15 physiological measures was used to investigate the sensorimotor, cardiovascular and neuromuscular adaptations to spaceflight...
April 3, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29620074/focal-cerebral-%C3%AE-amyloid-angiopathy-a-distinct-clinicopathologic-presentation
#10
Elissaios Karageorgiou, Georges Naasan, Samuel J Pleasure, Sanda Alexandrescu, Jeffrey M Gelfand, Gautam Tammewar, Bruce L Miller, Gil D Rabinovici, Lea T Grinberg
No abstract text is available yet for this article.
October 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29618456/functional-domains-of-the-fshd-associated-dux4-protein
#11
Hiroaki Mitsuhashi, Satoshi Ishimaru, Sachiko Homma, Bryant Yu, Yuki Honma, Mary Lou Beermann, Jeffrey Boone Miller
Aberrant expression of the full-length isoform of DUX4 (DUX4-FL) appears to underlie pathogenesis in facioscapulohumeral muscular dystrophy (FSHD). DUX4-FL is a transcription factor and ectopic expression of DUX4-FL is toxic to most cells. Previous studies showed that DUX4-FL-induced pathology requires intact homeodomains and that transcriptional activation required the C-terminal region. In this study, we further examined the functional domains of DUX4 by generating mutant, deletion, and fusion variants of DUX4...
April 4, 2018: Biology Open
https://www.readbyqxmd.com/read/29597002/a-phase-1-trial-of-cndo-109-activated-natural-killer-cells-in-patients-with-high-risk-acute-myeloid-leukemia
#12
Todd A Fehniger, Jeffrey S Miller, Robert K Stuart, Sarah Cooley, Amandeep Salhotra, Julie Curtsinger, Peter Westervelt, John F DiPersio, Timothy M Hillman, Nova Silver, Michael Szarek, Leonid Gorelik, Mark W Lowdell, Eric Rowinsky
Natural killer (NK) cells are an emerging immunotherapy approach to acute myeloid leukemia (AML); however, the optimal approach to activate NK cells before adoptive transfer remains unclear. Human NK cells that are primed with the CTV-1 leukemia cell line lysate CNDO-109 exhibit enhanced cytotoxicity against NK-cell-resistant cell lines. To translate this finding to the clinic, CNDO-109-activated NK cells (CNDO-109-NK cells) isolated from related human leukocyte antigen complex (HLA)-haploidentical donors were evaluated in a phase 1 dose-escalation trial at doses of 3×10^5 (n=3), 1×10^6 (n=3), and 3×10^6 (n=6) cells/kg in patients with AML in first complete remission (CR1) at high risk for recurrence...
March 26, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29596465/homozygous-ksr1-deletion-attenuates-morbidity-but-does-not-prevent-tumor-development-in-a-mouse-model-of-ras-driven-pancreatic-cancer
#13
Elizabeth A Germino, Joseph P Miller, Lauri Diehl, Carter J Swanson, Steffen Durinck, Zora Modrusan, Jeffrey H Miner, Andrey S Shaw
Given the frequency with which MAP kinase signaling is dysregulated in cancer, much effort has been focused on inhibiting RAS signaling for therapeutic benefit. KSR1, a pseudokinase that interacts with RAF, is a potential target; it was originally cloned in screens for suppressors of constitutively active RAS, and its deletion prevents RAS-mediated transformation of mouse embryonic fibroblasts. In this work, we used a genetically engineered mouse model of pancreatic cancer to assess whether KSR1 deletion would influence tumor development in the setting of oncogenic RAS...
2018: PloS One
https://www.readbyqxmd.com/read/29584493/numerical-investigation-of-driver-lower-extremity-injuries-in-finite-element-frontal-crash-reconstruction
#14
Xin Ye, James P Gaewsky, Logan E Miller, Derek A Jones, Mireille E Kelley, Jeffrey D Suhey, Bharath Koya, Ashley A Weaver, Joel D Stitzel
OBJECTIVE: Lower extremity injuries are the most frequent Abbreviated Injury Scale (AIS) 2 injury for drivers in frontal crashes. The objective was to reconstruct 11 real-world motor vehicle crashes (2 with AIS 2+ distal lower extremity injury and 9 without lower extremity injury) and to analyze the vehicle parameters and driver attributes that affect injury risk. METHODS: Eleven frontal crashes were reconstructed with a finite element simplified vehicle model (SVM) using a semi-automated optimization method...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29579620/ground-reaction-forces-during-a-drop-vertical-jump-impact-of-external-load-training
#15
Jeffrey D Simpson, Brandon L Miller, Eric K O'Neal, Harish Chander, Adam C Knight
External load training (ELT) is a supplemental training method used to potentially improve high intensity task performance. However, biomechanical parameters such as ground reaction forces (GRF), ground contact time, and time to peak GRF during a drop vertical jump (DVJ) following an ELT intervention have yet to be examined. Therefore, this study investigated the impact of ELT on certain biomechanical parameters of a DVJ task. Well-trained females stratified into two groups (ELT = 9, Control = 10) completed a DVJ from a 45...
March 23, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29578372/optimization-of-mrna-untranslated-regions-for-improved-expression-of-therapeutic-mrna
#16
Kirtika H Asrani, Jeremiah D Farelli, Mary R Stahley, Rebecca L Miller, Christopher J Cheng, Romesh R Subramanian, Jeffrey M Brown
mRNA based therapies hold great promise for the treatment of genetic diseases. However, this therapeutic approach suffers from multiple challenges including the short half-life of exogenously administered mRNA and subsequent protein production. Modulation of untranslated regions (UTR) represents one approach to enhance both mRNA stability and translation efficiency. The current studies describe and validate screening methods using a diverse set of 5'UTR and 3'UTR combinations for improved expression of the Arginase 1 (ARG1) protein, a potential therapeutic mRNA target...
March 26, 2018: RNA Biology
https://www.readbyqxmd.com/read/29577882/tpc2-mediated-ca-2-signaling-is-required-for-the-establishment-of-synchronized-activity-in-developing-zebrafish-primary-motor-neurons
#17
Jeffrey J Kelu, Sarah E Webb, Antony Galione, Andrew L Miller
During the development of the early spinal circuitry in zebrafish, spontaneous Ca2+ transients in the primary motor neurons (PMNs) are reported to transform from being slow and uncorrelated, to being rapid, synchronized and patterned. In this study, we demonstrated that in intact zebrafish, Ca2+ release +via two-pore channel type 2 (TPC2) from acidic stores/endolysosomes is required for the establishment of synchronized activity in the PMNs. Using the SAIGFF213A;UAS:GCaMP7a double-transgenic zebrafish line, Ca2+ transients were visualized in the caudal PMNs (CaPs)...
March 22, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29570003/economic-evaluation-of-global-endometrial-ablation-versus-inpatient-and-outpatient-hysterectomy-for-treatment-of-abnormal-uterine-bleeding-us-commercial-and-medicaid-payer-perspectives
#18
Jeffrey D Miller, Machaon M Bonafede, Qian Cai, Scott K Pohlman, Kathleen A Troeger, Aarathi Cholkeri-Singh
Every year, abnormal uterine bleeding (AUB) exacts a heavy toll on women's health and leads to high costs for the US health care system. The literature shows that endometrial ablation results in fewer complications, shorter recovery and lower costs than more commonly performed hysterectomy procedures. The objective of this study was to model clinical-economic outcomes, budget impact, and cost-effectiveness of global endometrial ablation (GEA) versus outpatient hysterectomy (OPH) and inpatient hysterectomy (IPH) procedures...
March 2018: Population Health Management
https://www.readbyqxmd.com/read/29568447/bond-breakage-under-pressure-in-a-metal-organic-framework
#19
Zhi Su, Yu-Run Miao, Guanghui Zhang, Jeffrey T Miller, Kenneth S Suslick
The internal free volume of porous materials diminishes upon mechanical compression, and such volume collapse can have chemical consequences. We report here the endothermic bond breakage in a metal-organic framework (MOF) during compression-induced collapse. Upon bulk compression at 1.9 GPa, the effective number for Zr-O bonds between Zr(iv) ions and carboxylate groups in UiO-66 decreased from 4.0 to 1.9, as determined by EXAFS, and the internal free volume was synchronously collapsed. Consistent with the EXAFS data, IR spectra confirmed conversion of syn - syn bridging carboxylates to monodentate ligation, thus establishing mechanochemical reactions induced by external compression of MOFs...
December 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29566793/genome-wide-analyses-identify-kif5a-as-a-novel-als-gene
#20
Aude Nicolas, Kevin P Kenna, Alan E Renton, Nicola Ticozzi, Faraz Faghri, Ruth Chia, Janice A Dominov, Brendan J Kenna, Mike A Nalls, Pamela Keagle, Alberto M Rivera, Wouter van Rheenen, Natalie A Murphy, Joke J F A van Vugt, Joshua T Geiger, Rick A Van der Spek, Hannah A Pliner, Shankaracharya, Bradley N Smith, Giuseppe Marangi, Simon D Topp, Yevgeniya Abramzon, Athina Soragia Gkazi, John D Eicher, Aoife Kenna, Gabriele Mora, Andrea Calvo, Letizia Mazzini, Nilo Riva, Jessica Mandrioli, Claudia Caponnetto, Stefania Battistini, Paolo Volanti, Vincenzo La Bella, Francesca L Conforti, Giuseppe Borghero, Sonia Messina, Isabella L Simone, Francesca Trojsi, Fabrizio Salvi, Francesco O Logullo, Sandra D'Alfonso, Lucia Corrado, Margherita Capasso, Luigi Ferrucci, Cristiane de Araujo Martins Moreno, Sitharthan Kamalakaran, David B Goldstein, Aaron D Gitler, Tim Harris, Richard M Myers, Hemali Phatnani, Rajeeva Lochan Musunuri, Uday Shankar Evani, Avinash Abhyankar, Michael C Zody, Julia Kaye, Steven Finkbeiner, Stacia K Wyman, Alex LeNail, Leandro Lima, Ernest Fraenkel, Clive N Svendsen, Leslie M Thompson, Jennifer E Van Eyk, James D Berry, Timothy M Miller, Stephen J Kolb, Merit Cudkowicz, Emily Baxi, Michael Benatar, J Paul Taylor, Evadnie Rampersaud, Gang Wu, Joanne Wuu, Giuseppe Lauria, Federico Verde, Isabella Fogh, Cinzia Tiloca, Giacomo P Comi, Gianni Sorarù, Cristina Cereda, Philippe Corcia, Hannu Laaksovirta, Liisa Myllykangas, Lilja Jansson, Miko Valori, John Ealing, Hisham Hamdalla, Sara Rollinson, Stuart Pickering-Brown, Richard W Orrell, Katie C Sidle, Andrea Malaspina, John Hardy, Andrew B Singleton, Janel O Johnson, Sampath Arepalli, Peter C Sapp, Diane McKenna-Yasek, Meraida Polak, Seneshaw Asress, Safa Al-Sarraj, Andrew King, Claire Troakes, Caroline Vance, Jacqueline de Belleroche, Frank Baas, Anneloor L M A Ten Asbroek, José Luis Muñoz-Blanco, Dena G Hernandez, Jinhui Ding, J Raphael Gibbs, Sonja W Scholz, Mary Kay Floeter, Roy H Campbell, Francesco Landi, Robert Bowser, Stefan M Pulst, John M Ravits, Daniel J L MacGowan, Janine Kirby, Erik P Pioro, Roger Pamphlett, James Broach, Glenn Gerhard, Travis L Dunckley, Christopher B Brady, Neil W Kowall, Juan C Troncoso, Isabelle Le Ber, Kevin Mouzat, Serge Lumbroso, Terry D Heiman-Patterson, Freya Kamel, Ludo Van Den Bosch, Robert H Baloh, Tim M Strom, Thomas Meitinger, Aleksey Shatunov, Kristel R Van Eijk, Mamede de Carvalho, Maarten Kooyman, Bas Middelkoop, Matthieu Moisse, Russell L McLaughlin, Michael A Van Es, Markus Weber, Kevin B Boylan, Marka Van Blitterswijk, Rosa Rademakers, Karen E Morrison, A Nazli Basak, Jesús S Mora, Vivian E Drory, Pamela J Shaw, Martin R Turner, Kevin Talbot, Orla Hardiman, Kelly L Williams, Jennifer A Fifita, Garth A Nicholson, Ian P Blair, Guy A Rouleau, Jesús Esteban-Pérez, Alberto García-Redondo, Ammar Al-Chalabi, Ekaterina Rogaeva, Lorne Zinman, Lyle W Ostrow, Nicholas J Maragakis, Jeffrey D Rothstein, Zachary Simmons, Johnathan Cooper-Knock, Alexis Brice, Stephen A Goutman, Eva L Feldman, Summer B Gibson, Franco Taroni, Antonia Ratti, Cinzia Gellera, Philip Van Damme, Wim Robberecht, Pietro Fratta, Mario Sabatelli, Christian Lunetta, Albert C Ludolph, Peter M Andersen, Jochen H Weishaupt, William Camu, John Q Trojanowski, Vivianna M Van Deerlin, Robert H Brown, Leonard H van den Berg, Jan H Veldink, Matthew B Harms, Jonathan D Glass, David J Stone, Pentti Tienari, Vincenzo Silani, Adriano Chiò, Christopher E Shaw, Bryan J Traynor, John E Landers
To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2)...
March 21, 2018: Neuron
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