keyword
MENU ▼
Read by QxMD icon Read
search

Jeffrey Miller

keyword
https://www.readbyqxmd.com/read/28322882/alcohol-control-psas-and-drunk-driving-fatal-accidents-in-the-united-states-1996-2010
#1
Jeffrey Niederdeppe, Rosemary Avery, Emily N Miller
Widespread concern regarding the detrimental effects of excessive alcohol consumption (especially by minors) and associated social problems (particularly drunk driving) continues to exist among policymakers, law enforcement officers, and the general public. Alcohol consumption is a leading contributor to death from injuries, which itself is one of the main causes of death for people under 21years of age in the United States. This study examines the relationship between the volume and timing of alcohol-control public service announcements (PSAs) and rates of drunk-driving fatal accidents in the U...
March 18, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28322704/transmission-of-hepatitis-a-virus-through-combined-liver-small-intestine-pancreas-transplantation
#2
Monique A Foster, Lauren M Weil, Sherry Jin, Thomas Johnson, Tonya R Hayden-Mixson, Yury Khudyakov, Pallavi D Annambhotla, Sridhar V Basavaraju, Saleem Kamili, Jana M Ritter, Noele Nelson, George Mazariegos, Michael Green, Ryan W Himes, David T Kuhar, Matthew J Kuehnert, Jeffrey A Miller, Rachel Wiseman, Anne C Moorman
Although transmission of hepatitis A virus (HAV) through blood transfusion has been documented, transmission through organ transplantation has not been reported. In August 2015, state health officials in Texas, USA, were notified of 2 home health nurses with HAV infection whose only common exposure was a child who had undergone multi-visceral organ transplantation 9 months earlier. Specimens from the nurses, organ donor, and all organ recipients were tested and medical records reviewed to determine a possible infection source...
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28315936/peptide-binding-motifs-of-two-common-equine-class-i-mhc-molecules-in-thoroughbred-horses
#3
Tobias Bergmann, Mikaela Lindvall, Erin Moore, Eugene Moore, John Sidney, Donald Miller, Rebecca L Tallmadge, Paisley T Myers, Stacy A Malaker, Jeffrey Shabanowitz, Nikolaus Osterrieder, Bjoern Peters, Donald F Hunt, Douglas F Antczak, Alessandro Sette
Quantitative peptide-binding motifs of MHC class I alleles provide a valuable tool to efficiently identify putative T cell epitopes. Detailed information on equine MHC class I alleles is still very limited, and to date, only a single equine MHC class I allele, Eqca-1*00101 (ELA-A3 haplotype), has been characterized. The present study extends the number of characterized ELA class I specificities in two additional haplotypes found commonly in the Thoroughbred breed. Accordingly, we here report quantitative binding motifs for the ELA-A2 allele Eqca-16*00101 and the ELA-A9 allele Eqca-1*00201...
March 18, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28315738/pulmonary-sarcomatoid-carcinomas-commonly-harbor-either-potentially-targetable-genomic-alterations-or-high-tumor-mutational-burden-as-observed-by-comprehensive-genomic-profiling
#4
Alexa B Schrock, Shuyu D Li, Garrett M Frampton, James Suh, Eduardo Braun, Ranee Mehra, Steven Buck, Jose A Bufill, Nir Peled, Nagla Abdel Karim, Cynthia Hsieh, Manuel Doria, James Knost, Rong Chen, Sai-Hong Ignatius Ou, Jeffrey S Ross, Philip J Stephens, Paul Fishkin, Vincent A Miller, Siraj M Ali, Balazs Halmos, Jane J Liu
BACKGROUND: Pulmonary sarcomatoid carcinoma (PSC) is a high-grade non-small cell lung carcinoma (NSCLC) characterized by poor prognosis and resistance to chemotherapy. Development of targeted therapeutic strategies for PSC has been hampered due to limited and inconsistent molecular characterization. METHODS: Hybrid-capture based comprehensive genomic profiling (CGP) was performed on DNA from 15,867 FFPE NSCLCs including 125 PSCs (0.8%). Tumor mutational burden (TMB) was calculated from 1...
March 15, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28291134/a-rapidly-growing-facial-mass-challenge
#5
Anna K Dewan, Deanna Dickerman, Eric Tkaczyk, Jeffrey P Zwerner, Alan Boyd, Jami L Miller
No abstract text is available yet for this article.
February 28, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28291133/a-rapidly-growing-facial-mass-answer
#6
Anna K Dewan, Deanna Dickerman, Eric Tkaczyk, Jeffrey P Zwerner, Alan Boyd, Jami L Miller
No abstract text is available yet for this article.
February 28, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28290782/prognostic-value-of-combined-ct-angiography-and-myocardial-perfusion-imaging-versus-invasive-coronary-angiography-and-nuclear-stress-perfusion-imaging-in-the-prediction-of-major-adverse-cardiovascular-events-the-core320-multicenter-study
#7
Marcus Y Chen, Carlos E Rochitte, Armin Arbab-Zadeh, Marc Dewey, Richard T George, Julie M Miller, Hiroyuki Niinuma, Kunihiro Yoshioka, Kakuya Kitagawa, Hajime Sakuma, Roger Laham, Andrea L Vavere, Rodrigo J Cerci, Vishal C Mehra, Cesar Nomura, Klaus F Kofoed, Masahiro Jinzaki, Sachio Kuribayashi, Arthur J Scholte, Michael Laule, Swee Yaw Tan, John Hoe, Narinder Paul, Frank J Rybicki, Jeffrey A Brinker, Andrew E Arai, Matthew B Matheson, Christopher Cox, Melvin E Clouse, Marcelo F Di Carli, João A C Lima
Purpose To compare the prognostic importance (time to major adverse cardiovascular event [MACE]) of combined computed tomography (CT) angiography and CT myocardial stress perfusion imaging with that of combined invasive coronary angiography (ICA) and stress single photon emission CT myocardial perfusion imaging. Materials and Methods This study was approved by all institutional review boards, and written informed consent was obtained. Between November 2009 and July 2011, 381 participants clinically referred for ICA and aged 45-85 years were enrolled in the Combined Noninvasive Coronary Angiography and Myocardial Perfusion Imaging Using 320-Detector Row Computed Tomography (CORE320) prospective multicenter diagnostic study...
March 14, 2017: Radiology
https://www.readbyqxmd.com/read/28284654/validation-of-a-web-based-curriculum-for-resident-education-in-orthopedic-surgery-j-surg-educ-2016-1060-65
#8
Barrett Boody, Patrick Johnston, Andrew Pugely, Daniel Miller, Jeffrey Geller, William Payne, James Boegener, Michael Schafer, Matthew Beal
No abstract text is available yet for this article.
March 8, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28283584/clinical-benefit-in-response-to-palbociclib-treatment-in-refractory-uterine-leiomyosarcomas-with-a-common-cdkn2a-alteration
#9
Julia A Elvin, Laurie M Gay, Rita Ort, Joseph Shuluk, Jennifer Long, Lauren Shelley, Ronald Lee, Zachary R Chalmers, Garrett M Frampton, Siraj M Ali, Alexa B Schrock, Vincent A Miller, Philip J Stephens, Jeffrey S Ross, Richard Frank
BACKGROUND: Uterine leiomyosarcoma (uLMS) responds poorly to conventional chemotherapeutic agents, and personalized therapies have yet to be systematically explored. Comprehensive genomic profiling (CGP) can identify therapeutic targets and provide insight into the biology of this highly aggressive tumor. We report a case of uLMS treated with the CGP-matched therapy palbociclib, a CDK4/6 inhibitor, with sustained clinical benefit in this rare and deadly malignancy. MATERIALS AND METHODS: This study analyzed 279 clinically advanced/recurrent uLMS samples...
March 10, 2017: Oncologist
https://www.readbyqxmd.com/read/28281393/altered-expression-of-a-metformin-mediated-radiation-response-in-sa-nh-and-fsa-tumor-cells-treated-under-in-vitro-and-in-vivo-growth-conditions
#10
Jeffrey S Murley, Richard C Miller, Raziye Rana Senlik, Alfred W Rademaker, David J Grdina
PURPOSE: To assess the radio-sensitizing effect of the biguanide drug Metformin used alone or in combination with reactive oxygen species (ROS) modifying agents N-acetyl-L-cysteine (NAC) or emodin, and contrasted to the mitochondrial complex 1 inhibitor rotenone in altering the radiation responses of the p53 wild type SA-NH and p53 mutant FSa mouse tumor lines grown either in vitro or in vivo. MATERIALS AND METHODS: Tumor cells were grown to confluence in vitro and exposed to a single 4 Gy dose in the presence or absence of Metformin (5 mM) and ROS modifiers or to 10 Gy with or without Metformin as tumors in the flanks of C3H mice using a tumor growth delay assay...
March 10, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28278296/robust-growth-of-avirulent-phase-ii-coxiella-burnetii-in-bone-marrow-derived-murine-macrophages
#11
Diane C Cockrell, Carrie M Long, Shelly J Robertson, Jeffrey G Shannon, Heather E Miller, Lara Myers, Charles L Larson, Tregei Starr, Paul A Beare, Robert A Heinzen
Published data show that murine bone marrow-derived macrophages (BMDM) restrict growth of avirulent phase II, but not virulent phase I, Coxiella burnetii. Growth restriction of phase II bacteria is thought to result from potentiated recognition of pathogen-associated molecular patterns, which leads to production of inhibitory effector molecules. Past studies have used conditioned medium from L-929 murine fibroblasts as a source of macrophage-colony stimulating factor (M-CSF) to promote differentiation of bone marrow-derived myeloid precursors into macrophages...
2017: PloS One
https://www.readbyqxmd.com/read/28269562/polyimide-based-magnetic-microactuators-for-biofouling-removal
#12
Qi Yang, Tran Nguyen, Chunan Liu, Jacob Miller, Jeffrey F Rhoads, Jacqueline Linnes, Hyowon Lee
Here we report on the development of novel polyimide-based flexible magnetic actuators for improving hydrocephalus shunts. The static and dynamic mechanical responses of the thin-film magnetic microdevices were quantitatively measured. The bacteria-removing capabilities of the microfabricated devices were also evaluated. Although additional evaluations are necessary, the preliminary results show promising potential for combatting bacteria-induced biofouling. Lastly, the thin-film microdevices are integrated into a single-pore silicone catheter to demonstrate a proof-of-concept, MEMS-enabled self-clearing, smart catheter...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28265087/classroom-sound-can-be-used-to-classify-teaching-practices-in-college-science-courses
#13
Melinda T Owens, Shannon B Seidel, Mike Wong, Travis E Bejines, Susanne Lietz, Joseph R Perez, Shangheng Sit, Zahur-Saleh Subedar, Gigi N Acker, Susan F Akana, Brad Balukjian, Hilary P Benton, J R Blair, Segal M Boaz, Katharyn E Boyer, Jason B Bram, Laura W Burrus, Dana T Byrd, Natalia Caporale, Edward J Carpenter, Yee-Hung Mark Chan, Lily Chen, Amy Chovnick, Diana S Chu, Bryan K Clarkson, Sara E Cooper, Catherine Creech, Karen D Crow, José R de la Torre, Wilfred F Denetclaw, Kathleen E Duncan, Amy S Edwards, Karen L Erickson, Megumi Fuse, Joseph J Gorga, Brinda Govindan, L Jeanette Green, Paul Z Hankamp, Holly E Harris, Zheng-Hui He, Stephen Ingalls, Peter D Ingmire, J Rebecca Jacobs, Mark Kamakea, Rhea R Kimpo, Jonathan D Knight, Sara K Krause, Lori E Krueger, Terrye L Light, Lance Lund, Leticia M Márquez-Magaña, Briana K McCarthy, Linda J McPheron, Vanessa C Miller-Sims, Christopher A Moffatt, Pamela C Muick, Paul H Nagami, Gloria L Nusse, Kristine M Okimura, Sally G Pasion, Robert Patterson, Pleuni S Pennings, Blake Riggs, Joseph Romeo, Scott W Roy, Tatiane Russo-Tait, Lisa M Schultheis, Lakshmikanta Sengupta, Rachel Small, Greg S Spicer, Jonathon H Stillman, Andrea Swei, Jennifer M Wade, Steven B Waters, Steven L Weinstein, Julia K Willsie, Diana W Wright, Colin D Harrison, Loretta A Kelley, Gloriana Trujillo, Carmen R Domingo, Jeffrey N Schinske, Kimberly D Tanner
Active-learning pedagogies have been repeatedly demonstrated to produce superior learning gains with large effect sizes compared with lecture-based pedagogies. Shifting large numbers of college science, technology, engineering, and mathematics (STEM) faculty to include any active learning in their teaching may retain and more effectively educate far more students than having a few faculty completely transform their teaching, but the extent to which STEM faculty are changing their teaching methods is unclear...
March 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28263858/predicting-mortality-and-independence-at-discharge-in-the-aging-traumatic-brain-injury-population-using-data-available-at-admission
#14
Preston R Miller, Michael C Chang, J Jason Hoth, Amy N Hildreth, Stacey Q Wolfe, Jessica L Gross, R Shayn Martin, Jeffrey E Carter, J Wayne Meredith, Ralph D'Agostino
INTRODUCTION: Aging worsens outcome in traumatic brain injury (TBI), but available studies may not provide accurate outcome predictions due to confounding associated injuries. Our goal was to develop a predictive tool using variables available at admission to predict outcome related to severity of brain injury in aging patients. METHODS: Characteristics and outcomes of blunt trauma patients with isolated TBI of ages ≥ 50 in National Trauma Data Bank (NTDB) were evaluated...
January 31, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28262021/synthesis-of-the-%C3%AE-secretase-modulator-mk-8428
#15
Steven P Miller, William J Morris, Robert K Orr, Jeffrey Eckert, Jay Milan, Mathew Maust, Cameron Cowden, Jian Cui
The synthesis of the γ-secretase modulator MK-8428 (1) is described. The synthesis is highlighted by an enzyme-catalyzed reaction to access 3,4,5-trifluoro-(S)-phenylglycine, a 1-pot activation/displacement/deprotection sequence to introduce the aminooxy functionality and a dehydrative intramolecular cyclization under mild conditions to form the oxadiazine heterocycle of 1. In situ reaction monitoring was employed to understand the deleterious role of water during the formation of a methanesulfonate ester in the 1-pot activation/displacement/deprotection sequence...
March 6, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28251903/integrated-molecular-analysis-of-tumor-biopsies-on-sequential-ctla-4-and-pd-1-blockade-reveals-markers-of-response-and-resistance
#16
Whijae Roh, Pei-Ling Chen, Alexandre Reuben, Christine N Spencer, Peter A Prieto, John P Miller, Vancheswaran Gopalakrishnan, Feng Wang, Zachary A Cooper, Sangeetha M Reddy, Curtis Gumbs, Latasha Little, Qing Chang, Wei-Shen Chen, Khalida Wani, Mariana Petaccia De Macedo, Eveline Chen, Jacob L Austin-Breneman, Hong Jiang, Jason Roszik, Michael T Tetzlaff, Michael A Davies, Jeffrey E Gershenwald, Hussein Tawbi, Alexander J Lazar, Patrick Hwu, Wen-Jen Hwu, Adi Diab, Isabella C Glitza, Sapna P Patel, Scott E Woodman, Rodabe N Amaria, Victor G Prieto, Jianhua Hu, Padmanee Sharma, James P Allison, Lynda Chin, Jianhua Zhang, Jennifer A Wargo, P Andrew Futreal
Immune checkpoint blockade produces clinical benefit in many patients. However, better biomarkers of response are still needed, and mechanisms of resistance remain incompletely understood. To address this, we recently studied a cohort of melanoma patients treated with sequential checkpoint blockade against cytotoxic T lymphocyte antigen-4 (CTLA-4) followed by programmed death receptor-1 (PD-1) and identified immune markers of response and resistance. Building on these studies, we performed deep molecular profiling including T cell receptor sequencing and whole-exome sequencing within the same cohort and demonstrated that a more clonal T cell repertoire was predictive of response to PD-1 but not CTLA-4 blockade...
March 1, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28249074/variation-in-the-cost-of-managing-actinic-keratosis
#17
Joslyn S Kirby, Tanner Gregory, Guodong Liu, Douglas L Leslie, Jeffrey J Miller
Importance: Actinic keratosis (AK), a skin growth induced by ultraviolet light exposure, requires chronic management because a small proportion can progress into squamous cell skin cancer. Spending for AK management was more than $1 billion in 2004. Investigating geographic variation in AK spending presents an opportunity to decrease waste or recoup excess spending. Objective: To evaluate geographic variation in health care cost for management of AKs and the association with patient-related and health-related factors...
March 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28235761/high-throughput-genomic-profiling-of-adult-solid-tumors-reveals-novel-insights-into-cancer-pathogenesis
#18
Ryan J Hartmaier, Lee Albacker, Juliann Chmielecki, Mark Bailey, Jie He, Michael E Goldberg, Shakti Ramkissoon, James Suh, Julia A Elvin, Samuel Chiacchia, Garrett M Frampton, Jeffrey S Ross, Vincent Miller, Philip J Stephens, Doron Lipson
Genomic profiling is widely predicted to become a standard of care in clinical oncology, but more effective data sharing to accelerate progress in precision medicine will be required. Here we describe cancer-associated genomic profiles from 18,004 unique adult cancers. The dataset was composed of 162 tumor subtypes including multiple rare and uncommon tumors. Comparison of alteration frequencies to The Cancer Genome Atlas (TCGA) identified some differences and suggested an enrichment of treatment-refractory samples in breast and lung cancer cohorts...
February 24, 2017: Cancer Research
https://www.readbyqxmd.com/read/28231426/engineering-of-anti-cd133-tri-specific-molecule-capable-of-inducing-nk-expansion-and-driving-antibody-dependent-cell-mediated-cytotoxicity-adcc
#19
Jörg U Schmohl, Martin Felices, Felix Oh, Alexander J Lenvik, Aaron M Lebeau, Jayanth Panyam, Jeffrey S Miller, Daniel A Vallera
Purpose: The selective elimination of cancer stem cells (CSCs) in tumor patients is a crucial goal because CSCs cause drug refractory relapse. To improve the current conventional bispecific immune-engager platform, a 16133 BiKE, consisting of scFvs binding FcγRIII (CD16) on NK cells and CD133 on carcinoma cells, was first synthesized and a modified IL-15 crosslinker capable of stimulating NK effector cells was introduced. Materials and Methods: DNA shuffling and ligation techniques were used to assemble and synthesize the 1615133 trispecific NK cell engager (TriKE)...
February 20, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28228115/weight-loss-and-exercise-for-communities-with-arthritis-in-north-carolina-we-can-design-and-rationale-of-a-pragmatic-assessor-blinded-randomized-controlled-trial
#20
Stephen P Messier, Leigh F Callahan, Daniel P Beavers, Kate Queen, Shannon L Mihalko, Gary D Miller, Elena Losina, Jeffrey N Katz, Richard F Loeser, Sara A Quandt, Paul DeVita, David J Hunter, Mary F Lyles, Jovita Newman, Betsy Hackney, Joanne M Jordan
BACKGROUND: Recently, we determined that in a rigorously monitored environment an intensive diet-induced weight loss of 10% combined with exercise was significantly more effective at reducing pain in men and women with symptomatic knee osteoarthritis (OA) than either intervention alone. Compared to previous long-term weight loss and exercise trials of knee OA, our intensive diet-induced weight loss and exercise intervention was twice as effective at reducing pain intensity. Whether these results can be generalized to less intensively monitored cohorts is unknown...
February 22, 2017: BMC Musculoskeletal Disorders
keyword
keyword
59186
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"