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J Miller

Alexandre Chlenski, Marija Dobratic, Helen R Salwen, Mark Applebaum, Lisa J Guerrero, Ryan Miller, Gillian DeWane, Elena Solomaha, Jeremy D Marks, Susan L Cohn
SPARC is a matrix protein that mediates interactions between cells and the microenvironment. In cancer, SPARC may either promote or inhibit tumor growth depending upon the tumor type. In neuroblastoma, SPARC is expressed in the stromal Schwannian cells and functions as a tumor suppressor. Here, we developed a novel in vivo model of stroma-rich neuroblastoma using non-tumorigenic SHEP cells with modulated levels of SPARC, mixed with tumorigenic KCNR cells. Tumors with stroma-derived SPARC displayed suppressed growth, inhibited angiogenesis and increased lipid accumulation...
October 20, 2016: Oncotarget
Laura Mannocci, Jason J Roberts, David L Miller, Patrick N Halpin
As human activities expand beyond national jurisdictions to the high seas, there is increasing need to consider anthropogenic impacts to species that inhabit these waters. The current scarcity of scientific observations of cetaceans in the high seas impedes the assessment of population-level impacts of these activities. This study is directed towards an important management need in the high seas-the development of plausible density estimates to facilitate a quantitative assessment of anthropogenic impacts on cetacean populations in these waters...
October 24, 2016: Conservation Biology: the Journal of the Society for Conservation Biology
Joannie Lortet-Tieulent, Ann Goding Sauer, Rebecca L Siegel, Kimberly D Miller, Farhad Islami, Stacey A Fedewa, Eric J Jacobs, Ahmedin Jemal
Importance: State-specific information about the health burden of smoking is valuable because state-level initiatives are at the forefront of tobacco control. Smoking-attributable cancer mortality estimates are currently available nationally and by cancer, but not by state. Objective: To calculate the proportion of cancer deaths among adults 35 years and older that were attributable to cigarette smoking in 2014 in each state and the District of Columbia. Design, Setting, and Participants: The population-attributable fraction (PAF) of cancer deaths due to cigarette smoking was computed using relative risks for 12 smoking-related cancers (acute myeloid leukemia and cancers of the oral cavity and pharynx; esophagus; stomach; colorectum; liver; pancreas; larynx; trachea, lung, and bronchus; cervix uteri; kidney and renal pelvis; and urinary bladder) from large US prospective studies and state-specific smoking prevalence data from the Behavioral Risk Factor Surveillance System...
October 24, 2016: JAMA Internal Medicine
Eliza C Miller, Hajere J Gatollari, Gloria Too, Amelia K Boehme, Lisa Leffert, Mitchell S V Elkind, Joshua Z Willey
Importance: Older age is associated with increased risk of pregnancy-associated stroke (PAS). Data are limited on age-specific incidence ratios of PAS compared with stroke risk in nonpregnant women. Objectives: To assess the risk of stroke by age group in pregnant and postpartum women compared with their nonpregnant contemporaries and to compare risk factors across age groups in the exposed (pregnant/postpartum) and unexposed (nonpregnant) populations. Design, Setting, and Participants: International Classification of Diseases, Ninth Revision, billing codes from the calendar year 2003-2012 New York State Department of Health inpatient database and population data were used to identify all women aged 12 to 55 years with cerebrovascular events, including transient ischemic attack, ischemic and hemorrhagic stroke, cerebral venous thrombosis, and nonspecified PAS...
October 24, 2016: JAMA Neurology
Stephen J Sheinkopf, Elena J Tenenbaum, Daniel S Messinger, Cynthia L Miller-Loncar, Ed Tronick, Linda L Lagasse, Seetha Shankaran, Henrietta Bada, Charles Bauer, Toni Whitaker, Jane Hammond, Barry M Lester
Using existing longitudinal data from 570 infants in the Maternal Lifestyle Study, we explored the predictive value of maternal and infant affect and maternal vocalizations during 2 minutes of face-to-face interactions at 4 months on IQ scores at 4.5 and 7 years. After controlling for demographic factors, maternal depression, and prenatal drug exposure, maternal positive affect and maternal positive vocalizations emerged as predictors of both verbal and performance IQ at 4.5 and 7 years. Although infant positive affect during the interaction with the mother was not predictive of these outcome measures, infant positive affect towards an examiner predicted verbal but not performance IQ at 4...
October 23, 2016: Developmental Science
K J Coppell, J C Miller, A R Gray, M Schultz, J I Mann, W R Parnell
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD), defined as excessive fat accumulation in hepatocytes when no other pathologic causes are present, is an increasingly common obesity-related disorder. We sought to describe the prevalence of elevated liver enzymes, a marker of liver damage, among New Zealand adults, and high-risk subgroups including those with an elevated body mass index and those with pre-diabetes or diabetes, to gain a better understanding of the burden of liver disease...
December 2015: Obesity Science & Practice
Pearlie P Chong, David van Duin, Ananta Bangdiwala, Anastasia Ivanova, William C Miller, David J Weber, Peter H Gilligan, Thomas C Shea
PURPOSE: Case reports of treatment failure with standard-dose daptomycin (6 mg/kg) have recently surfaced in vancomycin-resistant Enterococcus (VRE) bloodstream infection (BSI) episodes with daptomycin MICs of 3 to 4 mg/L. The clinical implications of daptomycin MICs of 3 to 4 mg/L in VRE BSIs have not been elucidated. METHODS: We performed a single institutional retrospective analysis of adult stem cell transplant recipients and patients with hematologic malignancies diagnosed with VRE BSI from 2006 to 2014 and compared outcomes between those with daptomycin MICs of 3 to 4 mg/L those with 2 mg/L, as determined by Etest...
October 19, 2016: Clinical Therapeutics
Alema Galijatovic-Idrizbegovic, Judith E Miller, Wendy D Cornell, James A Butler, Gordon K Wollenberg, Frank D Sistare, Joseph J DeGeorge
Chronic (>3 months) preclinical toxicology studies are conducted to support the safe conduct of clinical trials exceeding 3 months in duration. We have conducted a review of 32 chronic toxicology studies in non-rodents (22 studies in dogs and 10 in non-human primates) and 27 chronic toxicology studies in rats dosed with Merck compounds to determine the frequency at which additional target organ toxicities are observed in chronic toxicology studies as compared to subchronic studies of 3 months in duration...
October 18, 2016: Regulatory Toxicology and Pharmacology: RTP
John Stogner, Julia A Martinez, Bryan Lee Miller, Kenneth J Sher
BACKGROUND: Underage college students who obtain and use false identification (fake ID) are at risk for negative outcomes. However, it is currently unclear how uniquely the fake ID itself serves as a vehicle to subsequent harm (i.e., the "fake ID effect") over and above general and trait-related risk factors (e.g., deviant peers, low self-control). METHODS: To investigate whether the "fake ID effect" would hold after accounting for phenotypic risk, we utilized propensity score matching (PSM) in a cross-sectional sample of 1,454 students, and a longitudinal replication sample of 3,720 undergraduates...
October 21, 2016: Alcoholism, Clinical and Experimental Research
Stephanie H Cook, Robert-Paul Juster, Benjamin J Calebs, Justin Heinze, Alison L Miller
Much of the extant scientific research examining hypothalamic-pituitary-adrenal (HPA)-axis functioning is conducted among White heterosexuals. Very little research examines HPA-axis functioning between different minority groups. Individuals who identify as both sexual and racial minorities may experience increased stigma and discrimination that can affect HPA-axis functioning. In the current study, we examined diurnal cortisol rhythm in young White gay men (WGM) compared to young Black gay men (BGM). The sample consisted of 70 healthy gay men (mean [SD] age=22...
October 13, 2016: Psychoneuroendocrinology
Nicole A Hawkins, Nicole J Zachwieja, Alison R Miller, Lyndsey L Anderson, Jennifer A Kearney
A substantial number of mutations have been identified in voltage-gated sodium channel genes that result in various forms of human epilepsy. SCN1A mutations result in a spectrum of severity ranging from mild febrile seizures to Dravet syndrome, an infant-onset epileptic encephalopathy. Dravet syndrome patients experience multiple seizures types that are often refractory to treatment, developmental delays, and elevated risk for SUDEP. The same sodium channel mutation can produce epilepsy phenotypes of varying clinical severity...
October 2016: PLoS Genetics
P Adamson, F P An, I Anghel, A Aurisano, A B Balantekin, H R Band, G Barr, M Bishai, A Blake, S Blyth, G J Bock, D Bogert, D Cao, G F Cao, J Cao, S V Cao, T J Carroll, C M Castromonte, W R Cen, Y L Chan, J F Chang, L C Chang, Y Chang, H S Chen, Q Y Chen, R Chen, S M Chen, Y Chen, Y X Chen, J Cheng, J-H Cheng, Y P Cheng, Z K Cheng, J J Cherwinka, S Childress, M C Chu, A Chukanov, J A B Coelho, L Corwin, D Cronin-Hennessy, J P Cummings, J de Arcos, S De Rijck, Z Y Deng, A V Devan, N E Devenish, X F Ding, Y Y Ding, M V Diwan, M Dolgareva, J Dove, D A Dwyer, W R Edwards, C O Escobar, J J Evans, E Falk, G J Feldman, W Flanagan, M V Frohne, M Gabrielyan, H R Gallagher, S Germani, R Gill, R A Gomes, M Gonchar, G H Gong, H Gong, M C Goodman, P Gouffon, N Graf, R Gran, M Grassi, K Grzelak, W Q Gu, M Y Guan, L Guo, R P Guo, X H Guo, Z Guo, A Habig, R W Hackenburg, S R Hahn, R Han, S Hans, J Hartnell, R Hatcher, M He, K M Heeger, Y K Heng, A Higuera, A Holin, Y K Hor, Y B Hsiung, B Z Hu, T Hu, W Hu, E C Huang, H X Huang, J Huang, X T Huang, P Huber, W Huo, G Hussain, J Hylen, G M Irwin, Z Isvan, D E Jaffe, P Jaffke, C James, K L Jen, D Jensen, S Jetter, X L Ji, X P Ji, J B Jiao, R A Johnson, J K de Jong, J Joshi, T Kafka, L Kang, S M S Kasahara, S H Kettell, S Kohn, G Koizumi, M Kordosky, M Kramer, A Kreymer, K K Kwan, M W Kwok, T Kwok, K Lang, T J Langford, K Lau, L Lebanowski, J Lee, J H C Lee, R T Lei, R Leitner, J K C Leung, C Li, D J Li, F Li, G S Li, Q J Li, S Li, S C Li, W D Li, X N Li, Y F Li, Z B Li, H Liang, C J Lin, G L Lin, S Lin, S K Lin, Y-C Lin, J J Ling, J M Link, P J Litchfield, L Littenberg, B R Littlejohn, D W Liu, J C Liu, J L Liu, C W Loh, C Lu, H Q Lu, J S Lu, P Lucas, K B Luk, Z Lv, Q M Ma, X B Ma, X Y Ma, Y Q Ma, Y Malyshkin, W A Mann, M L Marshak, D A Martinez Caicedo, N Mayer, K T McDonald, C McGivern, R D McKeown, M M Medeiros, R Mehdiyev, J R Meier, M D Messier, W H Miller, S R Mishra, I Mitchell, M Mooney, C D Moore, L Mualem, J Musser, Y Nakajima, D Naples, J Napolitano, D Naumov, E Naumova, J K Nelson, H B Newman, H Y Ngai, R J Nichol, Z Ning, J A Nowak, J O'Connor, J P Ochoa-Ricoux, A Olshevskiy, M Orchanian, R B Pahlka, J Paley, H-R Pan, J Park, R B Patterson, S Patton, G Pawloski, V Pec, J C Peng, A Perch, M M Pfützner, D D Phan, S Phan-Budd, L Pinsky, R K Plunkett, N Poonthottathil, C S J Pun, F Z Qi, M Qi, X Qian, X Qiu, A Radovic, N Raper, B Rebel, J Ren, C Rosenfeld, R Rosero, B Roskovec, X C Ruan, H A Rubin, P Sail, M C Sanchez, J Schneps, A Schreckenberger, P Schreiner, R Sharma, S Moed Sher, A Sousa, H Steiner, G X Sun, J L Sun, N Tagg, R L Talaga, W Tang, D Taychenachev, J Thomas, M A Thomson, X Tian, A Timmons, J Todd, S C Tognini, R Toner, D Torretta, K Treskov, K V Tsang, C E Tull, G Tzanakos, J Urheim, P Vahle, N Viaux, B Viren, V Vorobel, C H Wang, M Wang, N Y Wang, R G Wang, W Wang, X Wang, Y F Wang, Z Wang, Z M Wang, R C Webb, A Weber, H Y Wei, L J Wen, K Whisnant, C White, L Whitehead, L H Whitehead, T Wise, S G Wojcicki, H L H Wong, S C F Wong, E Worcester, C-H Wu, Q Wu, W J Wu, D M Xia, J K Xia, Z Z Xing, J L Xu, J Y Xu, Y Xu, T Xue, C G Yang, H Yang, L Yang, M S Yang, M T Yang, M Ye, Z Ye, M Yeh, B L Young, Z Y Yu, S Zeng, L Zhan, C Zhang, H H Zhang, J W Zhang, Q M Zhang, X T Zhang, Y M Zhang, Y X Zhang, Z J Zhang, Z P Zhang, Z Y Zhang, J Zhao, Q W Zhao, Y B Zhao, W L Zhong, L Zhou, N Zhou, H L Zhuang, J H Zou
Searches for a light sterile neutrino have been performed independently by the MINOS and the Daya Bay experiments using the muon (anti)neutrino and electron antineutrino disappearance channels, respectively. In this Letter, results from both experiments are combined with those from the Bugey-3 reactor neutrino experiment to constrain oscillations into light sterile neutrinos. The three experiments are sensitive to complementary regions of parameter space, enabling the combined analysis to probe regions allowed by the Liquid Scintillator Neutrino Detector (LSND) and MiniBooNE experiments in a minimally extended four-neutrino flavor framework...
October 7, 2016: Physical Review Letters
P Adamson, I Anghel, A Aurisano, G Barr, M Bishai, A Blake, G J Bock, D Bogert, S V Cao, T J Carroll, C M Castromonte, R Chen, S Childress, J A B Coelho, L Corwin, D Cronin-Hennessy, J K de Jong, S De Rijck, A V Devan, N E Devenish, M V Diwan, C O Escobar, J J Evans, E Falk, G J Feldman, W Flanagan, M V Frohne, M Gabrielyan, H R Gallagher, S Germani, R A Gomes, M C Goodman, P Gouffon, N Graf, R Gran, K Grzelak, A Habig, S R Hahn, J Hartnell, R Hatcher, A Holin, J Huang, J Hylen, G M Irwin, Z Isvan, C James, D Jensen, T Kafka, S M S Kasahara, G Koizumi, M Kordosky, A Kreymer, K Lang, J Ling, P J Litchfield, P Lucas, W A Mann, M L Marshak, N Mayer, C McGivern, M M Medeiros, R Mehdiyev, J R Meier, M D Messier, W H Miller, S R Mishra, S Moed Sher, C D Moore, L Mualem, J Musser, D Naples, J K Nelson, H B Newman, R J Nichol, J A Nowak, J O'Connor, M Orchanian, R B Pahlka, J Paley, R B Patterson, G Pawloski, A Perch, M M Pfützner, D D Phan, S Phan-Budd, R K Plunkett, N Poonthottathil, X Qiu, A Radovic, B Rebel, C Rosenfeld, H A Rubin, P Sail, M C Sanchez, J Schneps, A Schreckenberger, P Schreiner, R Sharma, A Sousa, N Tagg, R L Talaga, J Thomas, M A Thomson, X Tian, A Timmons, J Todd, S C Tognini, R Toner, D Torretta, G Tzanakos, J Urheim, P Vahle, B Viren, A Weber, R C Webb, C White, L Whitehead, L H Whitehead, S G Wojcicki, R Zwaska
We report results of a search for oscillations involving a light sterile neutrino over distances of 1.04 and 735 km in a ν_{μ}-dominated beam with a peak energy of 3 GeV. The data, from an exposure of 10.56×10^{20} protons on target, are analyzed using a phenomenological model with one sterile neutrino. We constrain the mixing parameters θ_{24} and Δm_{41}^{2} and set limits on parameters of the four-dimensional Pontecorvo-Maki-Nakagawa-Sakata matrix, |U_{μ4}|^{2} and |U_{τ4}|^{2}, under the assumption that mixing between ν_{e} and ν_{s} is negligible (|U_{e4}|^{2}=0)...
October 7, 2016: Physical Review Letters
Miles A White, Gordon J Miller, Javier Vela
The first example of polytypism in the I-II-V semiconductors has been demonstrated with the synthesis of cubic LiZnSb by low temperature solution phase methods. This phase exhibits a unique coloring pattern that is novel for this class of compounds. The choice of site configuration has considerable impact on the band structure of these materials which, in turn, effects the transport properties. While the hexagonal polytype has been suggested as a promising n-type and extremely poor p-type thermoelectric material, the cubic analogue is calculated to have high efficiencies at 600K for both n- and p-type derivatives of 1...
October 21, 2016: Journal of the American Chemical Society
Anne M Murray, Fang-Chi Hsu, Jeff D Williamson, R Nick Bryan, Hertzel C Gerstein, Mark D Sullivan, Michael E Miller, Iris Leng, Laura L Lovato, Lenore J Launer
AIMS/HYPOTHESIS: The Memory in Diabetes (MIND) substudy of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study, a double 2x2 factorial parallel-group randomised clinical trial, tested whether intensive compared with standard management of hyperglycaemia, BP or lipid levels reduced cognitive decline and brain atrophy in 2977 people with type 2 diabetes. We describe the results of the observational extension study, ACCORDION MIND ( registration no. NCT00182910), which aimed to measure the long-term effects of the three ACCORD interventions on cognitive and brain structure outcomes approximately 4 years after the trial ended...
October 20, 2016: Diabetologia
Joseph E Tanenbaum, Vincent J Alentado, Jacob A Miller, Daniel Lubelski, Edward C Benzel, Thomas E Mroz
BACKGROUND CONTEXT: Lumbar fusion is a common and costly procedure in the United States. Reimbursement for surgical procedures is increasingly tied to care quality and patient safety as part of value-based reimbursement programs. The incidence of adverse quality events among lumbar fusion patients is unknown using the definition of care quality (patient safety indicators [PSI]) utilized by the Centers for Medicare and Medicaid Services (CMS). The association between insurance status and the incidence of PSI is similarly unknown in lumbar fusion patients...
October 17, 2016: Spine Journal: Official Journal of the North American Spine Society
Jeremiah T Lowe, Edward J Testa, Xinning Li, Suzanne Miller, Joseph P DeAngelis, Andrew Jawa
BACKGROUND: Computed tomography (CT) scan is the standard for the preoperative assessment of glenoid version and morphology before total shoulder arthroplasty. However, the capacity of magnetic resonance imaging (MRI) to visualize bone morphology has improved with advancing technology. The purpose of this study was to compare the accuracy of MRI to CT for assessment of glenoid version and Walch classification. METHODS: Three fellowship-trained shoulder surgeons assessed glenoid version and Walch classification of 30 patients with primary shoulder osteoarthritis who received both CT and MRI scans before total shoulder arthroplasty...
October 17, 2016: Journal of Shoulder and Elbow Surgery
J A Bohn, B M Kassaye, D Record, B C Chou, I L Kraft, J C Purdy, K A Hilton, D A Miller, S Getachew, A Addissie, J A Robison
BACKGROUND: Global childhood mortality rates remain high. Millennium Development Goal 4 focused efforts on reducing rates by two-thirds between 1990 and 2015. In Ethiopia, child mortality rates dropped 71 % from 1990 to 2015, however it is estimated that 184,000 Ethiopian children die each year. There is limited information about pediatric hospital admissions in Ethiopia. Our aims were to examine the temporal relationship of mortality to admission, describe the demographics, and identify cause mortality of children admitted to the Zewditu Memorial Hospital (ZMH)...
October 21, 2016: BMC Pediatrics
Vivek Subbiah, Oliver Holmes, Kyle Gowen, Daniel Spritz, Behrang Amini, Wei-Lien Wang, Alexa B Schrock, Funda Meric-Bernstam, Ralph Zinner, Sarina Piha-Paul, Maria Zarzour, Julia A Elvin, Rachel L Erlich, David L Stockman, Jo-Anne Vergilio, James H Suh, Philip J Stephens, Vincent Miller, Jeffrey S Ross, Siraj M Ali
Malignant gastrointestinal neuroectodermal tumor (GNET) is an aggressive rare tumor, primarily occurring in young adults with frequent local-regional metastases and recurrence after local control. The tumor is characterized by the presence of EWSR1-ATF1 or EWSR1-CREB1 and immunohistochemical positivity for S-100 protein without melanocytic marker positivity. Due to poor responses to standard sarcoma regimens, GNET has a poor prognosis, and development of effective systemic therapy is desperately needed to treat these patients...
October 21, 2016: Oncology
Monica L Castro-Acosta, Leanne Smith, Rosalind J Miller, Danielle I McCarthy, Jonathan A Farrimond, Wendy L Hall
Blackcurrants are rich in polyphenolic glycosides called anthocyanins, which may inhibit postprandial glycemia. The aim was to determine the dose-dependent effects of blackcurrant extract on postprandial glycemia. Men and postmenopausal women (14M, 9W, mean age 46 years, S.D.=14) were enrolled into a randomized, double-blind, crossover trial. Low sugar fruit drinks containing blackcurrant extract providing 150-mg (L-BE), 300-mg (M-BE) and 600-mg (H-BE) total anthocyanins or no blackcurrant extract (CON) were administered immediately before a high-carbohydrate meal...
September 14, 2016: Journal of Nutritional Biochemistry
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