keyword
https://read.qxmd.com/read/38391202/single-cell-cd4-and-cd8-t-cell-secretome-profiling-reveals-temporal-and-niche-differences-in-acute-myeloid-leukemia-following-immune-checkpoint-blockade-therapy
#21
JOURNAL ARTICLE
Jessica L Root, Poonam N Desai, Christopher Ly, Bofei Wang, Fatima Zahra Jelloul, Jing Zhou, Sean Mackay, Mansour Alfayez, Jairo Matthews, Sherry Pierce, Patrick K Reville, Naval Daver, Hussein A Abbas
Acute myeloid leukemia (AML) is a heterogeneous malignancy of the blood primarily treated with intensive chemotherapy. The allogeneic T cell anti-leukemic activity via donor lymphocyte infusions and stem cell transplantation suggests a potential role for checkpoint blockade therapy in AML. While clinical trials employing these treatments have fallen short of expected results, a deeper exploration into the functional states of T cells in AML could bridge this knowledge gap. In this study, we analyzed the polyfunctional activity of T cells in a cohort of relapsed/refractory (RelRef) AML patients treated on the clinical trial (ClinicalTrials...
February 23, 2024: Cancer Res Commun
https://read.qxmd.com/read/38380673/evaluation-of-outbreak-persistence-caused-by-multidrug-resistant-and-echinocandin-resistant-candida-parapsilosis-using-multidimensional-experimental-and-epidemiological-approaches
#22
JOURNAL ARTICLE
Farnaz Daneshnia, Daniel J Floyd, Adam P Ryan, Pegah Mosharaf Ghahfarokhy, Arefeh Ebadati, Sebastian Jusuf, Julieta Munoz, Nathan E Jeffries, Emma Elizabeth Yvanovich, Anna Apostolopoulou, Austin M Perry, Cornelia Lass-Flörl, Asuman Birinci, Süleyha Hilmioğlu-Polat, Macit Ilkit, Geraldine Butler, Clarissa J Nobile, Amir Arastehfar, Michael K Mansour
Candida parapsilosis is known to cause severe and persistent outbreaks in clinical settings. Patients infected with multidrug-resistant C. parapsilosis (MDR Cp) isolates were identified in a large Turkish hospital from 2017-2020. We subsequently identified three additional patients infected with MDR Cp isolates in 2022 from the same hospital and two echinocandin-resistant (ECR) isolates from a single patient in another hospital. The increasing number of MDR and ECR isolates contradicts the general principle that the severe fitness cost associated with these phenotypes could prevent their dominance in clinical settings...
February 21, 2024: Emerging Microbes & Infections
https://read.qxmd.com/read/38371071/long-term-outcomes-of-mechanical-versus-bioprosthetic-aortic-valve-replacement-a-systematic-review-and-meta-analysis
#23
REVIEW
Dilip K Vankayalapati, Omotayo Segun-Omosehin, Nour El Ghazal, Rohan Suresh Daniel, Joe El Haddad, Rania Mansour, Nathanael Yap, Shahid Miangul, Hayato Nakanishi, Christian A Than
This study aimed to investigate the safety and efficacy of bioprosthetic (BV) versus mechanical valves (MV) on long-term outcomes in 50- to 70-year-old aortic stenosis (AS) patients. A literature search for articles published until April 2023 yielded 13 eligible studies, with 15,320 patients divided into BV (n = 7,320) and MV (n = 8,000) cohorts. The review was registered prospectively with PROSPERO (CRD42021278777). MV demonstrated a favorable hazard ratio (HR: 1.12, 95% CI: 1.00-1.25, I2  = 60%) and higher survival rates at 5 (OR:1...
January 2024: Curēus
https://read.qxmd.com/read/38370793/-de-novo-mutations-mediate-phenotypic-switching-in-an-opportunistic-human-lung-pathogen
#24
Alexandra J Poret, Matthew Schaefers, Christina Merakou, Kathryn E Mansour, Georgia K Lagoudas, Ashley R Cross, Joanna B Goldberg, Roy Kishony, Ahmet Z Uluer, Alexander J McAdam, Paul C Blainey, Sara O Vargas, Tami D Lieberman, Gregory P Priebe
Bacteria evolving within human hosts encounter selective tradeoffs that render mutations adaptive in one context and deleterious in another. Here, we report that the cystic fibrosis-associated pathogen Burkholderia dolosa overcomes in-human selective tradeoffs by acquiring successive point mutations that alternate phenotypes. We sequenced the whole genomes of 931 respiratory isolates from two recently infected patients and an epidemiologically-linked, chronically-infected patient. These isolates are contextualized using 112 historical genomes from the same outbreak strain...
February 6, 2024: bioRxiv
https://read.qxmd.com/read/38305503/pulmonary-vein-narrowing-after-pulsed-field-versus-thermal-ablation
#25
JOURNAL ARTICLE
Moussa Mansour, Edward P Gerstenfeld, Chinmay Patel, Andrea Natale, William Whang, Frank A Cuoco, Stavros E Mountantonakis, Douglas N Gibson, John D Harding, Scott K Holland, Anitha B Achyutha, Christopher W Schneider, Andrew S Mugglin, Elizabeth M Albrecht, Kenneth M Stein, John W Lehmann, Vivek Y Reddy
BACKGROUND: When it occurs, pulmonary vein (PV) stenosis after atrial fibrillation (AF) ablation is associated with significant morbidity. Even mild-to-moderate PV narrowing may have long-term implications. Unlike thermal ablation energies such as radiofrequency (RF) or cryothermy, pulsed field ablation (PFA) is a non-thermal modality associated with less fibrotic proliferation. Herein, we compared the effects of PFA vs thermal ablation on PV narrowing after AF ablation. METHODS: ADVENT was a multicenter, randomized, single-blind study comparing PFA (pentaspline catheter) with thermal ablation - force-sensing RF or cryoballoon (CB) - to treat drug-refractory paroxysmal AF...
February 2, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://read.qxmd.com/read/38305390/synthesis-of-a-novel-gold-i-complex-and-evaluation-of-its-anticancer-properties-in-breast-cancer-cells
#26
JOURNAL ARTICLE
Haseeb A Khan, Anvarhusein A Isab, Abdullah S Alhomida, Mansour K Gatasheh, Ali Al-Hoshani, Bashayr A Aldhafeeri, N Rajendra Prasad
BACKGROUND: Platinum complexes are commonly used for cancer chemotherapy; however, they are not only highly-priced but also have various side effects. It is, therefore, important to design affordable anticancer drugs with minimal side effects. METHODS: We synthesized a new gold(I) complex, PF6{(BDPEA)(TPPMS) digold(I)} (abbreviated as PBTDG) and tested its cytotoxicity of MCF-7 breast cancer cells. We also evaluated the effects of PBTDG on mitochondrial membrane potential, generation of reactive oxygen species (ROS) and apoptosis in breast cancer cells...
January 4, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38286039/infection-control-measures-at-diagnostic-imaging-departments-in%C3%A2-governmental-hospitals-gaza-strip
#27
JOURNAL ARTICLE
M I Tabash, A A S Abu Saada, M AbuQamar, H H Mansour, Y Alajerami, K Abushab
INTRODUCTION: Infection prevention and control (IPC) is crucial in safeguarding patient safety and minimizing the risk of healthcare-associated infections. AIM: The study investigated infection prevention and control measures for diagnostic imaging departments at governmental hospitals in the Gaza Strip, Palestine. METHODS: The study design was a cross-sectional analytical study. The sample included all radiographers (81) and radiologists (40) working at Al Shifa Medical Complex and European Gaza Hospital (EGH)...
January 28, 2024: Radiography
https://read.qxmd.com/read/38274630/retraction-xanthogranulomatous-cholecystitis-a-rare-variant-of-chronic-cholecystitis
#28
Raghad K Alammari, Alanoud A Alhessan, Abdulaziz A Alturki, Safa A Aburowais, Mansour H Alsharif, Feras H Alshehri, Feddah M Hakami, Thawab M Alsubaie, Sukaina A Alhamed, Mosab A Alsobhi, Hussain A Alshaqaqiq, Ali I Alshaqaqiq, Abdullah H Alkharraz, Ali M Alhudhayf, Faisal Al-Hawaj
[This retracts the article DOI: 10.7759/cureus.21400.].
January 2024: Curēus
https://read.qxmd.com/read/38272601/social-determinants-of-health-screening-in-type-1-diabetes-management
#29
REVIEW
Nana-Hawa Yayah Jones, India Cole, Kelsey J Hart, Sarah Corathers, Shivani Agarwal, Ori Odugbesan, Osagie Ebekozien, Manmohan K Kamboj, Michael A Harris, Kathryn L Fantasia, Mona Mansour
Type 1 diabetes management is intricately influenced by social determinants of health. Economic status impacts access to vital resources like insulin and diabetes technology. Racism, social injustice, and implicit biases affect equitable delivery of care. Education levels affect understanding of self-care, leading to disparities in glycemic outcomes. Geographic location can limit access to health care facilities. Stressors from discrimination or financial strain can disrupt disease management. Addressing these social factors is crucial for equitable diabetes care, emphasizing the need for comprehensive strategies that go beyond medical interventions to ensure optimal health outcomes for all individuals with type 1 diabetes...
March 2024: Endocrinology and Metabolism Clinics of North America
https://read.qxmd.com/read/38260269/multispectral-fundus-photography-of-choroidal-nevi-with-trans-palpebral-illumination
#30
Mojtaba Rahimi, Alfa Rossi, Taeyoon Son, Albert K Dadzie, Behrouz Ebrahimi, Mansour Abtahi, Michael J Heiferman, Xincheng Yao
PURPOSE: To investigate the spectral characteristics of choroidal nevi and assess the feasibility of quantifying the basal diameter of choroidal nevi using multispectral fundus images captured with trans-palpebral illumination. METHODS: The study employed a widefield fundus camera with multispectral (625 nm, 780 nm, 850 nm, and 970 nm) trans-palpebral illumination. Geometric features of choroidal nevi, including border clarity, overlying drusen, and lesion basal diameter, were characterized...
January 13, 2024: medRxiv
https://read.qxmd.com/read/38251987/polyphenolic-profile-processing-impact-and-bioaccessibility-of-apple-fermented-products
#31
REVIEW
K Küçükgöz, J Echave, P Garcia-Oliveira, S Seyyedi-Mansour, P Donn, J Xiao, Monika Trząskowska, M A Prieto
Health-promoting foods have become increasingly popular due to intensified consumer interest and awareness of illnesses. There is a global market for apple fruits, which are affordable, nutritious, tasty, and produced in large quantities for direct consumption as well as food processing to make derived products. The food matrix of apples is suitable for fermentation, besides containing a high amount of phenolics and polyphenols. Fermentation of apples is one of the most common methods of preserving apple fruit and its byproducts...
January 22, 2024: Critical Reviews in Food Science and Nutrition
https://read.qxmd.com/read/38226348/a-survey-of-drive-thru-pharmacy-services-evaluating-the-acceptance-and-perspectives-of-community-pharmacists-in-saudi-arabia
#32
JOURNAL ARTICLE
Ibrahim M Asiri, Dina Y Alrastal, Rawan K Alaqeel, Fawaz M Alotaibi, Sawsan M Kurdi, Dhafer M Alshayban, Mohammed M Alsultan, Bassem A Almalki, Bashayer M AlShehail, Wafa A ALZlaiq, Mansour M Alotaibi, Muteb S Alanazi
BACKGROUND: The practice of dispensing drugs in primary healthcare centers has shifted to community pharmacies in Saudi Arabia. These changes increase demand and mandate improving their services; one such is establishing pharmacy drive-thru services. To explore the effects of drive-thru services on the pharmacy profession, this study aimed to measure community pharmacists' acceptance, perception, and satisfaction regarding drive-thru services. METHODS: This cross-sectional study design was conducted in Saudi Arabia between January 2023 and May 2023-comparing the perception, acceptance, and satisfaction of pharmacists who work in a community pharmacy that provides a drive-thru service versus no drive-thru service...
January 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38224470/serum-selenium-status-in-egyptians-patients-who-had-graves-disease-with-and-without-ophthalmopathy
#33
JOURNAL ARTICLE
Ghada A Hasanin, Magda S Mohamed, Maram M Maher, Azza M Ahmed, Hanan M ALi, Hany K Mansour
Selenium is efficient in reducing the progression of active Graves' orbitopathy and improving life quality. The impact of mending relative deficiency of selenium on improving Graves' orbitopathy is not known, due to the lack of previous measurement of baseline levels of selenium. The study object was to determine whether serum selenium levels are lower in patients with Graves' ophthalmopathy (GO) disease in comparison with those without ophthalmopathy. This prospective case control study was conducted between 2019 and 2021 at the endocrine and ophthalmology clinics, Ain Shams University, Cairo...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38223961/efficacy-of-three-interdental-cleaning-methods-for-peri-implant-health-maintenance-of-single-implant-supported-crowns-a-randomised-clinical-trial
#34
JOURNAL ARTICLE
Hani S AlMoharib, Mansour H AlAskar, Essam A Abuthera, Khalid A Alshalhoub, Faisal K BinRokan, Nawaf S AlQahtani, Hossam W Almadhoon
PURPOSE: To compare the effectiveness of an interproximal brush, a water flosser, and dental floss in removing plaque and reducing inflammation around implant-supported crowns. MATERIALS AND METHODS: A randomised controlled trial was conducted involving 45 participants with implant-supported single crowns. The participants were randomly assigned to three groups: interproximal brush, water flosser, and dental floss. Plaque index scores, gingival index scores, and interleukin-6 (IL-6) levels were assessed at baseline and after a two-week period...
January 15, 2024: Oral Health & Preventive Dentistry
https://read.qxmd.com/read/38186490/the-awareness-of-sudden-infant-death-among-saudi-arabian-women-in-2023
#35
JOURNAL ARTICLE
Sana A Sankari, Amal N AlZaaqi, Haya F AlDawood, Amirah A Alnaser, Lama K Alharbi, Raghad T Zakzouk, Mansour Alqurashi
Background Sudden infant death syndrome (SIDS) refers to the unexpected and unexplained death of a child under one year old. The pathogenesis of SIDS remains unclear. However, certain factors such as the child's sleeping position, sleeping on a soft mattress, and maternal smoking have been suggested to contribute to its occurrence. The objective of this study was to evaluate the level of awareness of SIDS among Saudi Arabian women in 2023...
December 2023: Curēus
https://read.qxmd.com/read/38185113/management-of-sinistral-portal-hypertension-after-pancreaticoduodenectomy
#36
REVIEW
Nabeel Mansour, Simon Sirtl, Martin K Angele, Moritz Wildgruber
BACKGROUND: Sinistral or left-sided portal hypertension (SPH) is a rare cause of upper gastrointestinal hemorrhage resulting from obstruction of the splenic vein. Venous drainage from the spleen via collaterals can result in venous hemorrhage both into the retroperitoneal and intraabdominal space due to increased venous blood pressure in peripancreatic and gastroduodenal vasculature. SPH can occur secondary to pancreatitis with thrombosis of the splenic vein. Another possible cause is the surgical ligation of the splenic vein as part of pancreaticoduodenectomy (PD)...
January 5, 2024: Digestive Diseases
https://read.qxmd.com/read/38168615/candida-albicans-extracellular-vesicles-trigger-type-i-ifn-signalling-via-cgas-and-sting
#37
JOURNAL ARTICLE
Hannah Brown Harding, Geneva N Kwaku, Christopher M Reardon, Nida S Khan, Daniel Zamith-Miranda, Robert Zarnowski, Jenny M Tam, Collins K Bohaen, Lauren Richey, Kenta Mosallanejad, Arianne J Crossen, Jennifer L Reedy, Rebecca A Ward, Diego A Vargas-Blanco, Kyle J Basham, Roby P Bhattacharyya, Jeniel E Nett, Michael K Mansour, Frank L van de Veerdonk, Vinod Kumar, Jonathan C Kagan, David R Andes, Joshua D Nosanchuk, Jatin M Vyas
The host type I interferon (IFN) pathway is a major signature of inflammation induced by the human fungal pathogen, Candida albicans. However, the molecular mechanism for activating this pathway in the host defence against C. albicans remains unknown. Here we reveal that mice lacking cyclic GMP-AMP synthase (cGAS)-stimulator of IFN genes (STING) pathway components had improved survival following an intravenous challenge by C. albicans. Biofilm-associated C. albicans DNA packaged in extracellular vesicles triggers the cGAS-STING pathway as determined by induction of interferon-stimulated genes, IFNβ production, and phosphorylation of IFN regulatory factor 3 and TANK-binding kinase 1...
January 2, 2024: Nature Microbiology
https://read.qxmd.com/read/38149067/the-prevalent-use-of-complementary-and-alternative-medicine-among-patients-with-chronic-disease-in-the-al-madinah-population-of-saudi-arabia
#38
JOURNAL ARTICLE
Ahmed S Metwally, Ibrahim A Atallah, Ibrahim K Almutairi, Mansour S Alzand, Mohammed S Alqabli
BACKGROUND: Global interest in complementary and alternative medicine (CAM) has recently risen, particularly in Saudi Arabia, and the use of CAM is gaining popularity as a healthcare option. OBJECTIVES: This study aims to assess the prevalence of CAM use among patients with chronic diseases and identify the reasons for resorting to CAM in Al-Madinah, Saudi Arabia. METHODS: A cross-sectional study was conducted in Al-Madinah City. Data for analysis were derived from 416 participants with chronic diseases...
December 2023: Curēus
https://read.qxmd.com/read/38144059/alternative-approach-to-access-5-hydroxy-1h-pyrrol-2-5h-ones-from-base-induced-tandem-intramolecular-cyclization-of-sulfur-ylide-with-ketones-and-1-3-hydroxy-rearrangement
#39
JOURNAL ARTICLE
Habbanakuppe D Preetham, Kothanahally S Sharath Kumar, Aravind Kandaswamy, Shobith Rangappa, Mansour K Gatasheh, Umashankara Muddegowda, Kanchugarakoppal S Rangappa
An easily adaptable protocol for the preparation of 5-hydroxy-1H-pyrrol-2(5H)-ones from readily available starting materials has been reported. The reaction of sulfur ylides with carbonyl compounds is a common approach to synthesizing epoxides. Alternatively, we have developed a method with mild reaction conditions wherein sulfur ylide underwent an intramolecular cyclization with a ketonic carbonyl group in a highly efficient way and was followed by 1,3-hydroxy rearrangement to produce 5-hydroxy-1H-pyrrol-2(5H)-ones in excellent yields...
December 19, 2023: ACS Omega
https://read.qxmd.com/read/38138671/bandgap-narrowing-of-batio-3-based-ferroelectric-oxides-through-cobalt-doping-for-photovoltaic-applications
#40
JOURNAL ARTICLE
Mansour K Gatasheh, Mohamed Saad Daoud, Hamoud Kassim
Following the finding of power conversion efficiency above the Shockley-Queisser limit in BaTiO3 (BTO) crystals, ferroelectric oxides have attracted scientific interest in ferroelectric photovoltaics (FPV). However, since ferroelectric oxides have a huge bandgap (>3 eV), progress in this sector is constrained. This paper proposes and demonstrates a new ferroelectric BaTi1-x Cox O3 powder (0 ≤ x ≤ 0.08), abbreviated as BTCx, that exhibited a bandgap decrease with increased Co content. Notably, changing the composition from x = 0...
December 6, 2023: Materials
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