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B Leshnower

Apoorva Girish, Muralidhar Padala, Kanika Kalra, Bryant V McIver, Ravi K Veeraswamy, Edward P Chen, Bradley G Leshnower
BACKGROUND: Partial false lumen (FL) thrombosis is a risk factor for long-term mortality in acute type B aortic dissection (ATBAD). This study investigates FL pressures in models of ATBAD with patent and partially thrombosed FL. METHODS: Twenty-five porcine aortas were used to create five models of ATBAD that were connected to a pulsatile flow loop. Models A through C had a patent FL with the following morphologies: model A, single proximal tear; model B, single distal tear; and model C, single proximal and single distal tear...
July 14, 2016: Annals of Thoracic Surgery
Richard C Gilmore, Vinod H Thourani, Hanna A Jensen, Jose Condado, José Nilo G Binongo, Eric L Sarin, Chandan M Devireddy, Bradley Leshnower, Kreton Mavromatis, Amjad Syed, Robert A Guyton, Peter C Block, Amy Simone, Patricia Keegan, James Stewart, Mohammad Rajaei, Brian Kaebnick, Stamatios Lerakis, Vasilis C Babaliaros
BACKGROUND: Chronic obstructive pulmonary disease (COPD) has been identified as a risk factor for morbidity and mortality after transcatheter aortic valve replacement (TAVR). We hypothesized that a portion of pulmonary dysfunction in patients with severe aortic stenosis may be of cardiac origin, and has potential to improve after TAVR. METHODS: A retrospective analysis was made of consecutive TAVR patients from April 2008 to October 2014. Of patients who had pulmonary function testing and serum B-type natriuretic peptide data available before and after TAVR, 58 were found to have COPD (26 mild, 14 moderate, and 18 severe)...
December 2015: Annals of Thoracic Surgery
Vinod H Thourani, Hanna A Jensen, Vasilis Babaliaros, Susheel K Kodali, Jeevanantham Rajeswaran, John Ehrlinger, Eugene H Blackstone, Rakesh M Suri, Creighton W Don, Gabriel Aldea, Mathew R Williams, Raj Makkar, Lars G Svensson, James M McCabe, Larry S Dean, Samir Kapadia, David J Cohen, Augusto D Pichard, Wilson Y Szeto, Howard C Herrmann, Chandan Devireddy, Bradley G Leshnower, Gorav Ailawadi, Hersh S Maniar, Rebecca T Hahn, Martin B Leon, Michael Mack
BACKGROUND: This study describes short-term and mid-term outcomes of nonagenarian patients undergoing transfemoral or transapical transcatheter aortic valve replacement (TAVR) in the Placement of Aortic Transcatheter Valve (PARTNER)-I trial. METHODS: From April 2007 to February 2012, 531 nonagenarians, mean age 93 ± 2.1 years, underwent TAVR with a balloon-expandable prosthesis in the PARTNER-I trial: 329 through transfemoral (TF-TAVR) and 202 transapical (TA-TAVR) access...
September 2015: Annals of Thoracic Surgery
Bradley G Leshnower, Vinod H Thourani, Michael E Halkos, Eric L Sarin, William B Keeling, Mark J Lamias, Robert A Guyton, Edward P Chen
BACKGROUND: Despite improved results with surgical therapy for acute type A aortic dissection (ATAAD), there remains a lack of consensus regarding the optimal method of cerebral protection and circulation management during ATAAD. The purpose of this study is to determine whether in the setting of antegrade cerebral perfusion, moderate hypothermic circulatory arrest (MHCA) provides equivalent cerebral and visceral protection as deep hypothermic circulatory arrest (DHCA) for patients undergoing emergent ATAAD repair...
November 2015: Annals of Thoracic Surgery
Joav Birjiniuk, Jean Marie Ruddy, Elizabeth Iffrig, Travis S Henry, Bradley G Leshnower, John N Oshinski, David N Ku, Ravi K Veeraswamy
BACKGROUND: Stanford type B dissection of the descending aorta is a potentially fatal condition that is poorly understood. Limited scientific understanding of the role of current interventional techniques, as well as heterogeneity in the condition, contributes to lack of consensus as to the most effective treatment strategy. This study introduces an anatomically accurate model for investigating aortic dissection in a laboratory setting. MATERIALS AND METHODS: A silicone model was fabricated and filled with fluid to mimic human blood...
October 2015: Journal of Surgical Research
William B Keeling, Bradley G Leshnower, Vinod H Thourani, Patrick S Kilgo, Edward P Chen
Proximal thoracic aortic reconstruction performed with or without hypothermic circulatory arrest (HCA) is an effective surgical strategy for aortic pathology. In this study, the clinical outcomes of patients undergoing reoperative proximal thoracic aortic surgery were evaluated. A retrospective review was performed for reoperative proximal aortic surgery from 2004 to date. Patient data were abstracted from the society of thoracic surgeons (STS) institutional database and patient charts. Univariate analysis was conducted on the HCA group in order to determine the impact of variables on in-hospital mortality...
July 2012: Interactive Cardiovascular and Thoracic Surgery
B G Leshnower, J T Potts, M G Garry, J H Mitchell
It is well known that the exercise pressor reflex (EPR) is mediated by group III and IV skeletal muscle afferent fibers, which exhibit unique discharge responses to mechanical and chemical stimuli. Based on the difference in discharge patterns of group III and IV muscle afferents, we hypothesized that activation of mechanically sensitive (MS) fibers would evoke a different pattern of cardiovascular responses compared with activation of both MS and chemosensitive (CS) fibers. Experiments were conducted in chloralose-urethane-anesthetized cats (n = 10)...
January 2001: Journal of Applied Physiology
J T Potts, I E Fuchs, J Li, B Leshnower, J H Mitchell
1. The tachykinin substance P was recovered from the commissural subdivision of the nucleus tractus solitarii (cNTS) using in vivo microdialysis during activation of cardiorespiratory and skeletal muscle receptors in thirteen chloralose-anaesthetized cats. 2. Tetanic muscle contraction was evoked by stimulating L7-S1 ventral roots (n = 7). Electrically induced muscle contraction increased mean arterial pressure (MAP) by 55 +/- 10 mmHg and heart rate by 29 +/- 6 beats min-1. During contraction the dialysate concentration increased 154 % above resting control levels (from 0...
February 1, 1999: Journal of Physiology
H B Shumacker, A C Leshnower
No abstract text is available yet for this article.
October 1974: Annals of Thoracic Surgery
A C Leshnower, H B Shumacker
No abstract text is available yet for this article.
October 1974: Archives of Surgery
A C Leshnower, H B Shumacker, A N Shariatzadeh
No abstract text is available yet for this article.
September 1974: American Journal of Surgery
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