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Brent Keeling

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https://www.readbyqxmd.com/read/27717426/the-racial-paradox-in-multiarterial-conduit-utilization-for-coronary-artery-bypass-grafting
#1
W Brent Keeling, Jose Binongo, Michael E Halkos, Bradley G Leshnower, Duc Q Nguyen, Edward P Chen, Eric L Sarin, Jeffrey S Miller, Steven Macheers, Omar M Lattouf, Robert A Guyton, Vinod H Thourani
BACKGROUND: It has been established that outcomes for black patients undergoing coronary artery bypass graft surgery (CABG) are inferior to those of their white counterparts. The purpose of this study was to determine (1) whether rates of multiarterial grafting are different among black patients and white patients, and (2) whether racial differences exist in postoperative outcomes after accounting for grafting strategy. METHODS: A retrospective review of black patients (n = 2,810) and white patients (n = 13,569) who underwent isolated, primary CABG from January 2002 to June 2014 at a US academic institution was performed...
October 4, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27711228/dna-mva-vaccination-of-hiv-1-infected-participants-with-viral-suppression-on-antiretroviral-therapy-followed-by-treatment-interruption-elicitation-of-immune-responses-without-control-of-re-emergent-virus
#2
Melanie Thompson, Sonya L Heath, Bentley Sweeton, Kathy Williams, Pamela Cunningham, Brandon F Keele, Sharon Sen, Brent E Palmer, Nicolas Chomont, Yongxian Xu, Rahul Basu, Michael S Hellerstein, Suefen Kwa, Harriet L Robinson
clinicaltrials.gov NCT01378156.
2016: PloS One
https://www.readbyqxmd.com/read/27666783/severity-of-preoperative-aortic-regurgitation-does-not-impact-valve-durability-of-aortic-valve-repair-following-the-david-v-valve-sparing-aortic-root-replacement
#3
W Brent Keeling, Bradley G Leshnower, Jose Binongo, Yi Lasanajak, LaRonica McPherson, Edward P Chen
BACKGROUND: The David V valve-sparing aortic root replacement (VSRR) is an established and durable method of root reconstruction for varying pathologies. However, the impact of the severity of preoperative aortic regurgitation (AR) on long-term durability remains unclear. The purpose of this research was to investigate the impact of the degree of preoperative AR on midterm durability following VSRR. METHODS: A retrospective review of the adult cardiac surgical database at a single academic center was undertaken from 2005 to 2015 for 223 adult patients who underwent VSRR...
September 22, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27373187/outcomes-after-surgical-pulmonary-embolectomy-for-acute-pulmonary-embolus-a-multi-institutional-study
#4
W Brent Keeling, Thor Sundt, Marzia Leacche, Yutaka Okita, Jose Binongo, Yi Lasajanak, Lishan Aklog, Omar M Lattouf
BACKGROUND: Surgical pulmonary embolectomy (SPE) has been sparingly used for the successful treatment of massive and submassive pulmonary emboli. To date, all data regarding SPE have been limited to single-center experiences. The purpose of this study was to document short-term outcomes after SPE for acute pulmonary emboli (PE) at four high-volume institutions. METHODS: A retrospective review of multiple local Society of Thoracic Surgeons databases of adults undergoing SPE from 1998 to 2014 for acute PE was performed (n = 214)...
November 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27321432/maxing-out-the-axillary-artery-for-arterial-cannulation-in-acute-type-a-dissection
#5
EDITORIAL
W Brent Keeling, Edward P Chen
No abstract text is available yet for this article.
September 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27169803/delayed-globin-synthesis-leads-to-excess-heme-and-the-macrocytic-anemia-of-diamond-blackfan-anemia-and-del-5q-myelodysplastic-syndrome
#6
Zhantao Yang, Siobán B Keel, Akiko Shimamura, Li Liu, Aaron T Gerds, Henry Y Li, Brent L Wood, Bart L Scott, Janis L Abkowitz
Diamond Blackfan anemia (DBA) and myelodysplastic syndrome (MDS) with isolated del(5q) are severe macrocytic anemias; although both are associated with impaired ribosome assembly, why the anemia occurs is not known. We cultured marrow cells from DBA (n = 3) and del(5q) MDS (n = 6) patients and determined how heme (a toxic chemical) and globin (a protein) are coordinated. We show that globin translation initiates slowly, whereas heme synthesis proceeds normally. This results in insufficient globin protein, excess heme and excess reactive oxygen species in early erythroid precursors, and CFU-E (colony-forming unit-erythroid)/proerythroblast cell death...
May 11, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/26992603/midterm-benefits-of-surgical-pulmonary-embolectomy-for-acute-pulmonary-embolus-on-right-ventricular-function
#7
William Brent Keeling, Bradley G Leshnower, Yi Lasajanak, Jose Binongo, Robert A Guyton, Michael E Halkos, Vinod H Thourani, Omar M Lattouf
OBJECTIVE: Surgical pulmonary embolectomy has been used for the successful treatment of massive and submassive pulmonary emboli. The purpose of this study is to document the short- and midterm echocardiographic follow-up of right ventricular function after surgical pulmonary embolectomy for acute pulmonary embolus. METHODS: A retrospective review of the local Society of Thoracic Surgeons database of patients who underwent surgical pulmonary embolectomy for acute pulmonary embolectomy was conducted from 1998 to 2014 at a US academic center...
September 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/26899959/injury-to-the-conduction-system-management-of-life-threatening-arrhythmias-after-penetrating-cardiac-trauma
#8
Rashi Jhunjhunwala, Christopher J Dente, William Brent Keeling, Phillip J Prest, Stacy D Dougherty, Rondi B Gelbard, William B Long, Jeffrey M Nicholas, Bryan C Morse
BACKGROUND: Life-threatening conduction abnormalities after penetrating cardiac injuries (PCIs) are rare, and rapid identification and treatment of these arrhythmias are critical to survival. This study highlights diagnosis and management strategies for conduction abnormalities after PCI. METHODS: Patients with life-threatening arrhythmias after PCI were identified at an urban, level I trauma center registry. RESULTS: Seventy-one patients survived to reach the hospital after PCI...
August 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/26586359/reaching-the-full-potential-of-mep-monitoring-during-surgery-of-the-thoracoabdominal-aorta
#9
EDITORIAL
Brent Keeling, Edward P Chen
No abstract text is available yet for this article.
February 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/26522523/invited-commentary
#10
COMMENT
Brent Keeling, Michael E Halkos
No abstract text is available yet for this article.
November 2015: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/26434701/the-real-root-cause-analysis-optimizing-surgical-options-in-the-current-era
#11
EDITORIAL
Brent Keeling, Edward P Chen
No abstract text is available yet for this article.
November 2015: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/26119513/double-transcatheter-valve-in-valve-therapy-a-viable-alternative-for-high-risk-patients
#12
EDITORIAL
Brent Keeling, Edward P Chen
No abstract text is available yet for this article.
August 2015: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/24803641/how-the-mountain-pine-beetle-dendroctonus-ponderosae-breached-the-canadian-rocky-mountains
#13
Jasmine K Janes, Yisu Li, Christopher I Keeling, Macaire M S Yuen, Celia K Boone, Janice E K Cooke, Joerg Bohlmann, Dezene P W Huber, Brent W Murray, David W Coltman, Felix A H Sperling
The mountain pine beetle (MPB; Dendroctonus ponderosae Hopkins), a major pine forest pest native to western North America, has extended its range north and eastward during an ongoing outbreak. Determining how the MPB has expanded its range to breach putative barriers, whether physical (nonforested prairie and high elevation of the Rocky Mountains) or climatic (extreme continental climate where temperatures can be below -40 °C), may contribute to our general understanding of range changes as well as management of the current epidemic...
July 2014: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/24011553/keloids-and-non-diabetic-kidney-disease-similarities-and-the-apol1-myh9-haplotype-as-a-possible-genetic-link
#14
Brett H Keeling, Brent R Taylor
Keloids and non-diabetic kidney disease are both fibrotic processes that disproportionately affect persons of African descent. Despite similarities in these conditions, the authors identified no studies to date investigating a shared genetic etiology. MYH9 and APOL1 are in linkage disequilibrium and have both been associated with non-diabetic kidney disease. MYH9 codes for a non-muscle myosin that is involved in cell adhesion and locomotion and is known to be overexpressed in keloids. Variations in APOL1 confer resistance to subspecies of Trypanosoma brucei, which may explain why otherwise deleterious genetic alterations in this haplotype could have gained prominence...
November 2013: Medical Hypotheses
https://www.readbyqxmd.com/read/23743061/off-pump-and-on-pump-coronary-revascularization-in-patients-with-low-ejection-fraction-a-report-from-the-society-of-thoracic-surgeons-national-database
#15
COMPARATIVE STUDY
W Brent Keeling, Matthew L Williams, Mark S Slaughter, Yue Zhao, John D Puskas
BACKGROUND: The purpose of this study was to evaluate outcomes of patients with low ejection fraction who underwent surgical coronary revascularization with or without cardiopulmonary bypass (CPB). METHODS: The Society of Thoracic Surgeons National Database was queried from January 1, 2008, to June 30, 2011 for patients with an ejection fraction of less than 0.30 who underwent primary, nonemergent coronary artery bypass (CAB) grafting. The entire cohort of 25,667 patients was divided into those who underwent revascularization with (ONCAB, n = 20,509) and without (OPCAB, n = 5,158) CPB...
July 2013: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/23140789/stabilizing-endothelium-of-donor-hearts-with-fusogenic-liposomes-reduces-myocardial-injury-and-dysfunction
#16
Tathyana F Fensterer, W Brent Keeling, Phani K Patibandla, Sathnur Pushpakumar, Gustavo Perez-Abadia, Philip Bauer, Chirag V Soni, Gary L Anderson, Claudio Maldonado
BACKGROUND: Myocardial injury after heart transplantation is a consequence of pathophysiologic events initiated by local ischemia/reperfusion injury that is further aggravated by the inflammatory response due to blood exposure to the pump's artificial surfaces during cardiopulmonary bypass. The purpose of the present study was to determine the effectiveness of fusogenic lipid vesicles (FLVs) in enhancing the cardioprotective effect of St. Thomas organ preservation solution (ST). We hypothesized that donor hearts preserved with ST+FLVs will stabilize the endothelium during reperfusion, which, in turn, will reduce both endothelial barrier dysfunction and myocardial damage...
June 15, 2013: Journal of Surgical Research
https://www.readbyqxmd.com/read/23084105/off-pump-coronary-artery-bypass-grafting-attenuates-morbidity-and-mortality-for-patients-with-low-and-high-body-mass-index
#17
W Brent Keeling, Patrick D Kilgo, John D Puskas, Michael E Halkos, Omar M Lattouf, Robert A Guyton, Vinod H Thourani
BACKGROUND: Patients at high and low body mass index have been shown to experience higher morbidity and mortality when undergoing coronary artery bypass grafting. The purpose of this research was to compare outcomes of patients at body mass index extremes who underwent coronary artery bypass grafting with or without cardiopulmonary bypass. METHODS: A retrospective review of 6801 patients with a body mass index <25 or >35 undergoing isolated, primary coronary artery bypass grafting from 1996 to 2009 at Emory Healthcare Hospitals was performed...
December 2013: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/21536247/impact-of-preoperative-renal-dysfunction-on-long-term-survival-for-patients-undergoing-aortic-valve-replacement
#18
Vinod H Thourani, W Brent Keeling, Eric L Sarin, Robert A Guyton, Patrick D Kilgo, Ameesh B Dara, John D Puskas, Edward P Chen, William A Cooper, J David Vega, Cullen D Morris, Michael E Halkos, Omar M Lattouf
BACKGROUND: The impact of the degrees of renal dysfunction (RD) after aortic valve replacement (AVR) has not been well described. The purpose of this study was to compare patients undergoing AVR with a range of renal function from normal to dialysis-dependence. METHODS: A retrospective review of 2,408 patients undergoing AVR with or without coronary artery bypass graft surgery (CABG) from January 1996 to March 2009 was performed. Glomerular filtration rate (GFR) was estimated for patients using the Modification of Diet in Renal Disease formula...
June 2011: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/21478626/innovations-in-therapies-for-heart-valve-disease
#19
REVIEW
Muralidhar Padala, William Brent Keeling, Robert A Guyton, Vinod H Thourani
The burden of heart valve disease among adults is enormous in the developed world. Increased life expectancy and age-related valvular degeneration remain the predominant contributors to heart valve dysfunction, which if uncorrected lead to congestive heart failure and increased morbidity and mortality. Clinical evidence on the detrimental impact of valve disease on both pediatric and adult populations has fueled growing interest in diagnosis and therapy for heart valve disease, and also significant financial investment from hospitals and medical device manufacturers in hybrid operating rooms and novel medical device technologies...
2011: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/21457476/permanent-genetic-resources-added-to-molecular-ecology-resources-database-1-december-2010-31-january-2011
#20
, Kiyokazu Agata, Samer Alasaad, Vera Maria Fonseca Almeida-Val, J A Alvarez-Dios, F Barbisan, Jon S Beadell, J F Beltrán, M Benítez, G Bino, Colin Bleay, P Bloor, Jörg Bohlmann, Warren Booth, E Boscari, Adalgisa Caccone, Tatiana Campos, B M Carvalho, Gisele Torres Climaco, Jean Clobert, L Congiu, Christina Cowger, G Dias, I Doadrio, Izeni Pires Farias, N Ferrand, Patrícia D Freitas, G Fusco, Pedro M Galetti, Cristian Gallardo-Escárate, Michael W Gaunt, Zaneli Gomez Ocampo, H Gonçalves, E G Gonzalez, Pilar Haye, O Honnay, Chaz Hyseni, H Jacquemyn, Michael J Jowers, Akihiro Kakezawa, Eri Kawaguchi, Christopher I Keeling, Ye-Seul Kwan, Michelangelo La Spina, Wan-Ok Lee, M Leśniewska, Yang Li, Haixia Liu, Xiaolin Liu, S Lopes, P Martínez, S Meeus, Brent W Murray, Aline G Nunes, Loyce M Okedi, Johnson O Ouma, B G Pardo, Ryan Parks, Maria Nazaré Paula-Silva, C Pedraza-Lara, Omaththage P Perera, A Pino-Querido, Murielle Richard, Bruno C Rossini, N Gayathri Samarasekera, Antonio Sánchez, Juan A Sanchez, Carlos Henrique Dos Anjos Santos, Wataru Shinohara, Ramón C Soriguer, Adna Cristina Barbosa Sousa, Carolina Fernandes Da Silva Sousa, Virginie M Stevens, M Tejedo, Myriam Valenzuela-Bustamante, M S Van de Vliet, K Vandepitte, M Vera, Peter Wandeler, Weimin Wang, Yong-Jin Won, A Yamashiro, T Yamashiro, Changcheng Zhu
This article documents the addition of 238 microsatellite marker loci to the Molecular Ecology Resources Database. Loci were developed for the following species: Alytes dickhilleni, Arapaima gigas, Austropotamobius italicus, Blumeria graminis f. sp. tritici, Cobitis lutheri, Dendroctonus ponderosae, Glossina morsitans morsitans, Haplophilus subterraneus, Kirengeshoma palmata, Lysimachia japonica, Macrolophus pygmaeus, Microtus cabrerae, Mytilus galloprovincialis, Pallisentis (Neosentis) celatus, Pulmonaria officinalis, Salminus franciscanus, Thais chocolata and Zootoca vivipara...
May 2011: Molecular Ecology Resources
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