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Seth Force

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https://www.readbyqxmd.com/read/27905864/determining-friction-and-effective-loading-for-sled-sprinting
#1
Matt R Cross, Farhan Tinwala, Seth Lenetsky, Pierre Samozino, Matt Brughelli, Jean-Benoit Morin
Understanding the impact of friction in sled sprinting allows the quantification of kinetic outputs and the effective loading experienced by the athlete. This study assessed changes in the coefficient of friction (µk) of a sled sprint-training device with changing mass and speed to provide a means of quantifying effective loading for athletes. A common sled equipped with a load cell was towed across an athletics track using a motorised winch under variable sled mass (33.1-99.6 kg) with constant speeds (0...
December 1, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27809773/electrocardiographic-and-echocardiographic-predictors-of-paroxysmal-atrial-fibrillation-detected-after-ischemic-stroke
#2
Maria A Baturova, Seth H Sheldon, Jonas Carlson, Peter A Brady, Grace Lin, Alejandro A Rabinstein, Paul A Friedman, Pyotr G Platonov
BACKGROUND: Detection of atrial fibrillation after ischemic stroke is challenging due to its paroxysmal nature. We aimed to assess predictors of paroxysmal atrial fibrillation using non-invasive surface ECG and transthoracic echocardiography to select candidates for atrial fibrillation screening. METHODS: Ischemic stroke patients without documented atrial fibrillation (n = 110, 67 ± 10 years, 40 female) and a control group of age- and gender-matched patients with history of paroxysmal atrial fibrillation prior to stroke (n = 55, 67 ± 10 years, 19 female) comprised the study sample...
November 3, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27784102/primary-care-interventions-to-support-breastfeeding-us-preventive-services-task-force-recommendation-statement
#3
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Karina W Davidson, John W Epling, Francisco A R García, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael P Pignone
Importance: There is convincing evidence that breastfeeding provides substantial health benefits for children. However, nearly half of all US mothers who initially breastfeed stop doing so by 6 months, and there are significant disparities in breastfeeding rates among younger mothers and in disadvantaged communities. Objective: To update the 2008 US Preventive Services Task Force (USPSTF) recommendation on primary care interventions to promote breastfeeding. Evidence Review: The USPSTF reviewed the evidence on the effectiveness of interventions to support breastfeeding on breastfeeding initiation, duration, and exclusivity...
October 25, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27645943/invited-commentary
#4
Seth Daniel Force
No abstract text is available yet for this article.
October 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27599331/screening-for-latent-tuberculosis-infection-in-adults-us-preventive-services-task-force-recommendation-statement
#5
COMMENT
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Linda Bauman, Karina W Davidson, John W Epling, Francisco A R García, Jessica Herzstein, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael P Pignone
IMPORTANCE: Tuberculosis remains an important preventable disease in the United States. An effective strategy for reducing the transmission, morbidity, and mortality of active disease is the identification and treatment of latent tuberculosis infection (LTBI) to prevent progression to active disease. OBJECTIVE: To issue a current US Preventive Services Task Force (USPSTF) recommendation on screening for LTBI. EVIDENCE REVIEW: The USPSTF reviewed the evidence on screening for LTBI in asymptomatic adults seen in primary care, including evidence dating from the inception of searched databases...
September 6, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27557662/restrictive-cardiomyopathy-troponin-i-r145w-mutation-does-not-perturb-myofilament-length-dependent-activation-in-human-cardiac-sarcomeres
#6
Alexey V Dvornikov, Nikolai Smolin, Mengjie Zhang, Jody L Martin, Seth L Robia, Pieter P de Tombe
The cardiac troponin I (cTnI) R145W mutation is associated with restrictive cardiomyopathy (RCM). Recent evidence suggests that this mutation induces perturbed myofilament length-dependent activation (LDA) under conditions of maximal protein kinase A (PKA) stimulation. Some cardiac disease-causing mutations, however, have been associated with a blunted response to PKA-mediated phosphorylation; whether this includes LDA is unknown. Endogenous troponin was exchanged in isolated skinned human myocardium for recombinant troponin containing either cTnI R145W, PKA/PKC phosphomimetic charge mutations (S23D/S24D and T143E), or various combinations thereof...
October 7, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27546963/posterior-polar-cataract-minimizing-risks
#7
Gaurav Kapoor, Sankalp Seth, T S Ahluwalia, S K Dhar
BACKGROUND: Comparing surgical outcomes of management of posterior polar cataract, a congenital cataract, which is difficult to manage surgically and has been associated with poor surgical outcomes. METHODS: 46 eyes of 38 patients with posterior polar cataract underwent phacoemulsification and PCIOL implantation. RESULTS: In a prospective analytical study, 46 eyes of 38 patients with posterior polar cataracts underwent surgery at a zonal hospital of the armed forces...
July 2016: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/27532917/screening-for-lipid-disorders-in-children-and-adolescents-us-preventive-services-task-force-recommendation-statement
#8
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Karina W Davidson, John W Epling, Francisco A R García, Matthew W Gillman, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Michael LeFevre, Carol M Mangione, Douglas K Owens, William R Phillips, Maureen G Phipps, Michael P Pignone, Albert L Siu
IMPORTANCE: Elevations in levels of total, low-density lipoprotein, and non-high-density lipoprotein cholesterol; lower levels of high-density lipoprotein cholesterol; and, to a lesser extent, elevated triglyceride levels are associated with risk of cardiovascular disease in adults. OBJECTIVE: To update the 2007 US Preventive Services Task Force (USPSTF) recommendation on screening for lipid disorders in children, adolescents, and young adults. EVIDENCE REVIEW: The USPSTF reviewed the evidence on screening for lipid disorders in children and adolescents 20 years or younger--1 review focused on screening for heterozygous familial hypercholesterolemia, and 1 review focused on screening for multifactorial dyslipidemia...
August 9, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27476821/socioeconomic-factors-are-associated-with-readmission-after-lobectomy-for-early-stage-lung-cancer
#9
Rachel L Medbery, Theresa W Gillespie, Yuan Liu, Dana C Nickleach, Joseph Lipscomb, Manu S Sancheti, Allan Pickens, Seth D Force, Felix G Fernandez
BACKGROUND: Data regarding risk factors for readmissions after surgical resection for lung cancer are limited and largely focus on postoperative outcomes, including complications and hospital length of stay. The current study aims to identify preoperative risk factors for postoperative readmission in early stage lung cancer patients. METHODS: The National Cancer Data Base was queried for all early stage lung cancer patients with clinical stage T2N0M0 or less who underwent lobectomy in 2010 and 2011...
November 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27458948/screening-for-skin-cancer-us-preventive-services-task-force-recommendation-statement
#10
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Karina W Davidson, Mark Ebell, John W Epling, Francisco A R García, Matthew W Gillman, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael P Pignone, Albert L Siu
IMPORTANCE: Basal and squamous cell carcinoma are the most common types of cancer in the United States and represent the vast majority of all cases of skin cancer; however, they rarely result in death or substantial morbidity, whereas melanoma skin cancer has notably higher mortality rates. In 2016, an estimated 76,400 US men and women will develop melanoma and 10,100 will die from the disease. OBJECTIVE: To update the 2009 US Preventive Services Task Force (USPSTF) recommendation on screening for skin cancer...
July 26, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27436288/rag1-targeting-in-the-genome-is-dominated-by-chromatin-interactions-mediated-by-the-non-core-regions-of-rag1-and-rag2
#11
Yaakov Maman, Grace Teng, Rashu Seth, Steven H Kleinstein, David G Schatz
The RAG1/RAG2 endonuclease initiates V(D)J recombination at antigen receptor loci but also binds to thousands of places outside of these loci. RAG2 localizes directly to lysine 4 trimethylated histone 3 (H3K4me3) through a plant homeodomain (PHD) finger. The relative contribution of RAG2-dependent and RAG1-intrinsic mechanisms in determining RAG1 binding patterns is not known. Through analysis of deep RAG1 ChIP-seq data, we provide a quantitative description of the forces underlying genome-wide targeting of RAG1...
November 16, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27376138/summary-and-recommendations-from-the-national-cancer-institute-s-clinical-trials-planning-meeting-on-novel-therapeutics-for-non-muscle-invasive-bladder-cancer
#12
Seth P Lerner, Dean F Bajorin, Colin P Dinney, Jason A Efstathiou, Susan Groshen, Noah M Hahn, Donna Hansel, David Kwiatkowski, Michael O'Donnell, Jonathan Rosenberg, Robert Svatek, Jeffrey S Abrams, Hikmat Al-Ahmadie, Andrea B Apolo, Joaquim Bellmunt, Margaret Callahan, Eugene K Cha, Charles Drake, Jonathan Jarow, Ashish Kamat, William Kim, Margaret Knowles, Bhupinder Mann, Luigi Marchionni, David McConkey, Lisa McShane, Nilsa Ramirez, Andrew Sharabi, Arlene H Sharpe, David Solit, Catherine M Tangen, Abdul Tawab Amiri, Eliezer Van Allen, Pamela J West, J A Witjes, Diane Zipursky Quale
The NCI Bladder Cancer Task Force convened a Clinical Trials Planning Meeting (CTPM) Workshop focused on Novel Therapeutics for Non-Muscle Invasive Bladder Cancer (NMIBC). Meeting attendees included a broad and multi-disciplinary group of clinical and research stakeholders and included leaders from NCI, FDA, National Clinical Trials Network (NCTN), advocacy and the pharmaceutical and biotech industry. The meeting goals and objectives were to: 1) create a collaborative environment in which the greater bladder research community can pursue future optimally designed novel clinical trials focused on the theme of molecular targeted and immune-based therapies in NMIBC; 2) frame the clinical and translational questions that are of highest priority; and 3) develop two clinical trial designs focusing on immunotherapy and molecular targeted therapy...
2016: Bladder Cancer
https://www.readbyqxmd.com/read/27363331/checklist-assessment-tool-to-evaluate-suitability-and-success-of-neonatal-clamp-circumcision-a-prospective-study
#13
Charles W Concodora, Max Maizels, Gregory E Dean, Dana A Weiss, Seth A Alpert, John D Edmondson, Jack S Elder, Anthony Herndon, James M Elmore, Karen Rychlik
BACKGROUND: The American Academy of Pediatrics (AAP) Task Force on Circumcision has called for the development of standards of trainee proficiency in regards to evaluation and technique for neonatal clamp circumcision (NCC). At the present time, there is no standardized or general consensus on patient selection for NCC. An improved method to evaluate newborns for NCC is an important first step in this process. Therefore, the authors collaborated to identify criteria useful in the evaluation of newborns for suitability for NCC, and for assessment of success after NCC and have named it "Checklist Assessment for Neonatal Clamp Circumcision Suitability...
August 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27304597/screening-for-colorectal-cancer-us-preventive-services-task-force-recommendation-statement
#14
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Karina W Davidson, John W Epling, Francisco A R García, Matthew W Gillman, Diane M Harper, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, Douglas K Owens, William R Phillips, Maureen G Phipps, Michael P Pignone, Albert L Siu
IMPORTANCE: Colorectal cancer is the second leading cause of cancer death in the United States. In 2016, an estimated 134,000 persons will be diagnosed with the disease, and about 49,000 will die from it. Colorectal cancer is most frequently diagnosed among adults aged 65 to 74 years; the median age at death from colorectal cancer is 68 years. OBJECTIVE: To update the 2008 US Preventive Services Task Force (USPSTF) recommendation on screening for colorectal cancer...
June 21, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27282647/micromechanical-properties-of-strain-sensitive-lyriform-organs-of-a-wandering-spider-cupiennius-salei
#15
Seth L Young, Marius Chyasnavichyus, Friedrich G Barth, Igor Zlotnikov, Yael Politi, Vladimir V Tsukruk
UNLABELLED: Highly sensitive lyriform organs located on the legs of the wandering spider Cupiennius salei allow the spider to detect nanometer-scale strains in the exoskeleton resulting from locomotion or substrate vibrations. Morphological features of the lyriform organs result in their specialization and selective sensitivity to specific mechanical stimuli, which make them interesting for bioinspired strain sensors. Here we utilize atomic force microscopy (AFM)-based force spectroscopy to probe nano-scale mechanical properties of the covering membrane of two lyriform organs found on Cupiennius salei: the vibration sensitive metatarsal lyriform organ (HS10) and the proprioreceptive tibial lyriform organ (HS8)...
September 1, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27279527/biomechanical-consequences-of-adding-plantar-fascia-release-to-metatarsal-osteotomies-changes-in-forefoot-plantar-pressures
#16
Umur Aydogan, Evan P Roush, Blake E Moore, Seth H Andrews, Gregory S Lewis
Destruction of the normal metatarsal arch by a long metatarsal is often a cause for metatarsalgia. When surgery is warranted, distal oblique or proximal dorsiflexion osteotomies of the long metatarsal bones are commonly used. The plantar fascia has anatomical connection to all metatarsal heads. There is controversial scientific evidence on the effect of plantar fascia release on forefoot biomechanics. In this cadaveric biomechanical study, we hypothesized that plantar fascia release would augment the plantar metatarsal pressure decreasing effects of two common second metatarsal osteotomy techniques...
June 9, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27272583/screening-for-syphilis-infection-in-nonpregnant-adults-and-adolescents-us-preventive-services-task-force-recommendation-statement
#17
REVIEW
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Karina W Davidson, John W Epling, Francisco A R García, Matthew W Gillman, Diane M Harper, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael P Pignone
IMPORTANCE: In 2014, 19,999 cases of syphilis were reported in the United States. Left untreated, syphilis can progress to late-stage disease in about 15% of persons who are infected. Late-stage syphilis can lead to development of inflammatory lesions throughout the body, which can lead to cardiovascular or organ dysfunction. Syphilis infection also increases the risk for acquiring or transmitting HIV infection. OBJECTIVE: To update the 2004 US Preventive Services Task Force (USPSTF) recommendation on screening for syphilis infection in nonpregnant adults...
June 7, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27225624/the-effects-of-hibernation-and-forced-disuse-neurectomy-on-bone-properties-in-arctic-ground-squirrels
#18
Lori K Bogren, Erin L Johnston, Zeinab Barati, Paula A Martin, Samantha J Wojda, Ian G Van Tets, Adrian D LeBlanc, Seth W Donahue, Kelly L Drew
Bone loss is a well-known medical consequence of disuse such as in long-term space flight. Immobilization in many animals mimics the effects of space flight on bone mineral density. Decreases in metabolism are also thought to contribute to a loss of skeletal mass. Hibernating mammals provide a natural model of disuse and metabolic suppression. Hibernating ground squirrels have been shown to maintain bone strength despite long periods of disuse and decreased metabolism during torpor. This study examined if the lack of bone loss during torpor was a result of the decrease in metabolic rate during torpor or an evolutionary change in these animals affording protection against disuse...
May 2016: Physiological Reports
https://www.readbyqxmd.com/read/27209617/time-is-money-hospital-costs-associated-with-video-assisted-thoracoscopic-surgery-lobectomies
#19
Onkar V Khullar, Felix G Fernandez, Sebastian Perez, William Knechtle, Allan Pickens, Manu S Sancheti, Seth D Force
BACKGROUND: Proposed changes in health care will place an increasing burden on surgeons to care for patients more efficiently to minimize cost. We reviewed costs surrounding video-assisted thoracoscopic surgery (VATS) lobectomies to see where changes could be made to ensure maximum value. METHODS: We queried The Society of Thoracic Surgeons database for all VATS lobectomies performed for lung cancer from January 2011 to December 2013. Clinical data were linked with hospital financial data to determine hospital expenditures for each patient...
September 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27208747/surfactants-induced-release-of-a-red-emitting-dye-from-the-nanocavity-of-a-molecular-container-a-spectroscopic-and-calorimetric-study
#20
Sayeed Ashique Ahmed, Aninda Chatterjee, Banibrata Maity, Debabrata Seth
Supramolecular interaction of a red emitting dye Nile blue A (NBA) with Cucurbit[7]uril (CB7) in aqueous solution was studied and the release of the dye from the hydrophobic cavity of CB7 was reported. To investigate the supramolecular host-guest complex formation and release of dye, we have used the steady state absorption, fluorescence and time resolved fluorescence emission spectroscopy, (1)H NMR spectroscopy and isothermal titration calorimetry (ITC). The spectral properties of NBA were changed in the presence of CB7...
August 2016: Journal of Photochemistry and Photobiology. B, Biology
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