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Felix Fernandez

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https://www.readbyqxmd.com/read/29342137/corrigendum-mtorc1-dependent-amd1-regulation-sustains-polyamine-metabolism-in-prostate-cancer
#1
Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Natalia Martín-Martín, Sonia Fernandez-Ruiz, James D Sutherland, Michelle Clasquin, Julen Tomas-Cortazar, Jose Jimenez, Ines Torres, Phong Quang, Pilar Ximenez-Embun, Ruzica Bago, Aitziber Ugalde-Olano, Ana Loizaga-Iriarte, Isabel Lacasa-Viscasillas, Miguel Unda, Verónica Torrano, Diana Cabrera, Sebastiaan M van Liempd, Ylenia Cendon, Elena Castro, Stuart Murray, Ajinkya Revandkar, Andrea Alimonti, Yinan Zhang, Amelia Barnett, Gina Lein, David Pirman, Ana R Cortazar, Leire Arreal, Ludmila Prudkin, Ianire Astobiza, Lorea Valcarcel-Jimenez, Patricia Zuñiga-García, Itziar Fernandez-Dominguez, Marco Piva, Alfredo Caro-Maldonado, Pilar Sánchez-Mosquera, Mireia Castillo-Martín, Violeta Serra, Naiara Beraza, Antonio Gentilella, George Thomas, Mikel Azkargorta, Felix Elortza, Rosa Farràs, David Olmos, Alejo Efeyan, Juan Anguita, Javier Muñoz, Juan M Falcón-Pérez, Rosa Barrio, Teresa Macarulla, Jose M Mato, Maria L Martinez-Chantar, Carlos Cordon-Cardo, Ana M Aransay, Kevin Marks, José Baselga, Josep Tabernero, Paolo Nuciforo, Brendan D Manning, Katya Marjon, Arkaitz Carracedo
This corrects the article DOI: 10.1038/nature22964.
January 17, 2018: Nature
https://www.readbyqxmd.com/read/29337918/polyacrylamide-ferrogels-with-magnetite-or-strontium-hexaferrite-next-step-in-the-development-of-soft-biomimetic-matter-for-biosensor-applications
#2
Alexander P Safronov, Ekaterina A Mikhnevich, Zahra Lotfollahi, Felix A Blyakhman, Tatyana F Sklyar, Aitor Larrañaga Varga, Anatoly I Medvedev, Sergio Fernández Armas, Galina V Kurlyandskaya
Magnetic biosensors are an important part of biomedical applications of magnetic materials. As the living tissue is basically a "soft matter." this study addresses the development of ferrogels (FG) with micron sized magnetic particles of magnetite and strontium hexaferrite mimicking the living tissue. The basic composition of the FG comprised the polymeric network of polyacrylamide, synthesized by free radical polymerization of monomeric acrylamide (AAm) in water solution at three levels of concentration (1...
January 16, 2018: Sensors
https://www.readbyqxmd.com/read/29329793/drug-use-family-support-and-related-factors-in-university-students-a-cross-sectional-study-based-on-the-unihcos-project-data
#3
Jorge Arias-De la Torre, Tania Fernández-Villa, Antonio José Molina, Carmen Amezcua-Prieto, Ramona Mateos, José María Cancela, Miguel Delgado-Rodríguez, Rocío Ortíz-Moncada, Juan Alguacil, Ana Almaraz, Inés Gómez-Acebo, María Morales Suárez-Varela, Gemma Blázquez-Abellán, Eladio Jiménez-Mejías, Luis Félix Valero, Carlos Ayán, Laura Vilorio-Marqués, Rocío Olmedo-Requena, Vicente Martín
OBJECTIVE: To assess the prevalence of illegal drug use in college students on any previous occasion, during the previous year and the previous month, and to analyze the relationship between illegal drug use and family support and other factors. METHODS: A cross-sectional study using data from students participating in the uniHcos project (n = 3767) was conducted. The prevalence and age of onset of consumption of cannabis, non-prescription sedatives, stimulants and depressants was evaluated...
January 9, 2018: Gaceta Sanitaria
https://www.readbyqxmd.com/read/29320160/efforts-aimed-to-reduce-attrition-in-antimalarial-drug-discovery-a-systematic-evaluation-of-current-antimalarial-targets-portfolio
#4
María Jesus Chaparro, Felix Calderon, Pablo Castañeda, Elena Fernandez Alvaro, Raquel Gabarro, Francisco-Javier Gamo, María G Gómez-Lorenzo, Julio Martín, Esther Fernandez
Malaria remains a major global health problem. In 2015 alone, more than 200 million cases of malaria were reported, and more than 400,000 deaths occurred. Since 2010, emerging resistance to current front-line ACTs (Artemisinin Combination Therapies) has been detected in endemic countries. Therefore, there is an urgency for new therapies based on novel modes of action, able to relieve symptoms as fast as the artemisinins and/or block malaria transmission. During the past few years, the antimalarial community has focused their efforts on phenotypic screening as a pragmatic approach to identify new hits...
January 10, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29315497/health-care-disparities-among-octogenarians-and-nonagenarians-with-stage-iii-lung-cancer
#5
Richard J Cassidy, Xinyan Zhang, Jeffrey M Switchenko, Pretesh R Patel, Joseph W Shelton, Sibo Tian, Ronica H Nanda, Conor E Steuer, Rathi N Pillai, Taofeek K Owonikoko, Suresh S Ramalingam, Felix G Fernandez, Seth D Force, Theresa W Gillespie, Walter J Curran, Kristin A Higgins
BACKGROUND: To the authors' knowledge, the practice patterns for patients aged more than 80 years with stage III non-small cell lung cancer (NSCLC) is not well known. The purpose of the current study was to investigate factors predictive of and the impact on overall survival (OS) after concurrent chemoradiation (CRT) among patients aged ≥80 years with American Joint Committee on Cancer stage III NSCLC in the National Cancer Data Base (NCDB). METHODS: In the NCDB, patients aged ≥80 years who were diagnosed with stage III NSCLC from 2004 to 2013 with complete treatment records were identified...
January 8, 2018: Cancer
https://www.readbyqxmd.com/read/29313321/the-matrix-synthesis-and-anti-inflammatory-effect-of-autologous-leukocyte-poor-platelet-rich-plasma-in-human-cartilage-explants
#6
Mario Simental-Mendía, Félix Vilchez-Cavazos, Rubén García-Garza, Jorge Lara-Arias, Roberto Montes-de-Oca-Luna, Salvador Said-Fernández, Herminia G Martínez-Rodríguez
OBJECTIVE: To determine the effects of autologous leukocyte-poor platelet-rich plasma (LP-PRP) on the expression of markers involved in cartilage-extracellular matrix production and inflammation in cartilage explants bearing osteoarthritis. MATERIALS AND METHODS: Cartilage explants and LP-PRP were obtained from 10 patients who underwent total knee arthroplasty. The explants were cultured in spinner flasks for 28 days in the presence of interleukin (IL)-1β and/or LP-PRP...
January 9, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29241096/study-of-non-covalent-interactions-on-dendriplex-formation-influence-of-hydrophobic-electrostatic-and-hydrogen-bonds-interactions
#7
María Sánchez-Milla, Isabel Pastor, Marek Maly, M Jesús Serramía, Rafael Gómez, Javier Sánchez-Nieves, Félix Ritort, M Ángeles Muñoz-Fernández, F Javier de la Mata
The interaction of a double stranded small interference RNA (siRNA Nef) with cationic carbosilane dendrimers of generations 1-3 with two different ammonium functions at the periphery ([-NMe2R]+, R=Me, (CH2)2OH) has been studied by experimental techniques (zeta potential, electrophoresis, single molecule pulling experiments) and molecular dynamic calculations. These studies state the presence of different forces on dendriplex formation, depending on generation and type of ammonium group. Whilst for higher dendrimers electrostatic forces mainly drive the stability of dendriplexes, first generation compounds can penetrate into siRNA strands due to the establishment of hydrophobic interactions...
December 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29233977/the-mitochondrial-negative-regulator-mcj-is-a-therapeutic-target-for-acetaminophen-induced-liver-injury
#8
Lucía Barbier-Torres, Paula Iruzubieta, David Fernández-Ramos, Teresa C Delgado, Daniel Taibo, Virginia Guitiérrez-de-Juan, Marta Varela-Rey, Mikel Azkargorta, Nicolas Navasa, Pablo Fernández-Tussy, Imanol Zubiete-Franco, Jorge Simon, Fernando Lopitz-Otsoa, Sofia Lachiondo-Ortega, Javier Crespo, Steven Masson, Misti Vanette McCain, Erica Villa, Helen Reeves, Felix Elortza, Maria Isabel Lucena, Maria Isabel Hernández-Alvarez, Antonio Zorzano, Raúl J Andrade, Shelly C Lu, José M Mato, Juan Anguita, Mercedes Rincón, María Luz Martínez-Chantar
Acetaminophen (APAP) is the active component of many medications used to treat pain and fever worldwide. Its overuse provokes liver injury and it is the second most common cause of liver failure. Mitochondrial dysfunction contributes to APAP-induced liver injury but the mechanism by which APAP causes hepatocyte toxicity is not completely understood. Therefore, we lack efficient therapeutic strategies to treat this pathology. Here we show that APAP interferes with the formation of mitochondrial respiratory supercomplexes via the mitochondrial negative regulator MCJ, and leads to decreased production of ATP and increased generation of ROS...
December 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29233331/the-society-of-thoracic-surgeons-adult-cardiac-surgery-database-2018-update-on-outcomes-and-quality
#9
Richard S D'Agostino, Jeffrey P Jacobs, Vinay Badhwar, Felix G Fernandez, Gaetano Paone, David W Wormuth, David M Shahian
Through nearly 3 decades of iterative refinement, The Society of Thoracic Surgeons Adult Cardiac Surgery Database has evolved into one of the most comprehensive and respected clinical data registries in health care. It is a widely acknowledged exemplar for accurately benchmarking risk-adjusted outcomes in cardiac surgery and underpins all quality measurement and improvement activities of The Society of Thoracic Surgeons. This is the latest in a series of annual reports that outlines current national aggregate outcomes and volume trends in cardiac surgery and summarizes database-related work in quality measurement and performance improvement during the past year...
January 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29221736/differential-effects-of-operative-complications-on-survival-after-surgery-for-primary-lung-cancer
#10
Felix G Fernandez, Andrzej S Kosinski, Anthony P Furnary, Mark Onaitis, Sunghee Kim, Robert H Habib, Betty C Tong, Patricia Cowper, Daniel Boffa, Jeffrey P Jacobs, Cameron D Wright, Joe B Putnam
OBJECTIVE: Complications adversely affect survival after lung cancer surgery. We tested the hypothesis that effects of complications after lung cancer surgery on survival vary substantially across the spectrum of postoperative complications. METHODS: The Society of Thoracic Surgeons General Thoracic Surgery Database was linked to Medicare data for lung cancer resections from 2002 through 2013. Linkage was achieved for 29,899 patients. A survival model was created that included operative complications as explanatory variables and adjusted for relevant baseline covariates...
November 13, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29217570/a-precise-measurement-of-the-magnetic-field-in-the-corona-of-the-black-hole-binary-v404-cygni
#11
Yigit Dallilar, Stephen S Eikenberry, Alan Garner, Richard D Stelter, Amy Gottlieb, Poshak Gandhi, Piergiorgio Casella, Vik S Dhillon, Tom R Marsh, Stuart P Littlefair, Liam Hardy, Rob Fender, Kunal Mooley, Dominic J Walton, Felix Fuerst, Matteo Bachetti, A J Castro-Tirado, Miguel Charcos, Michelle L Edwards, Nestor M Lasso-Cabrera, Antonio Marin-Franch, S Nicholas Raines, Kendall Ackley, John G Bennett, A Javier Cenarro, Brian Chinn, H Veronica Donoso, Raymond Frommeyer, Kevin Hanna, Michael D Herlevich, Jeff Julian, Paola Miller, Scott Mullin, Charles H Murphey, Chris Packham, Frank Varosi, Claudia Vega, Craig Warner, A N Ramaprakash, Mahesh Burse, Sujit Punnadi, Pravin Chordia, Andreas Gerarts, Héctor de Paz Martín, María Martín Calero, Riccardo Scarpa, Sergio Fernandez Acosta, William Miguel Hernández Sánchez, Benjamin Siegel, Francisco Francisco Pérez, Himar D Viera Martín, José A Rodríguez Losada, Agustín Nuñez, Álvaro Tejero, Carlos E Martín González, César Cabrera Rodríguez, Jordi Molgó, J Esteban Rodriguez, J Israel Fernández Cáceres, Luis A Rodríguez García, Manuel Huertas Lopez, Raul Dominguez, Tim Gaggstatter, Antonio Cabrera Lavers, Stefan Geier, Peter Pessev, Ata Sarajedini
Observations of binary stars containing an accreting black hole or neutron star often show x-ray emission extending to high energies (>10 kilo--electron volts), which is ascribed to an accretion disk corona of energetic particles akin to those seen in the solar corona. Despite their ubiquity, the physical conditions in accretion disk coronae remain poorly constrained. Using simultaneous infrared, optical, x-ray, and radio observations of the Galactic black hole system V404 Cygni, showing a rapid synchrotron cooling event in its 2015 outburst, we present a precise 461 ± 12 gauss magnetic field measurement in the corona...
December 8, 2017: Science
https://www.readbyqxmd.com/read/29203261/preoperative-computed-tomography-guided-pulmonary-lesion-marking-in-preparation-for-fluoroscopic-wedge-resection-rates-of-success-complications-and-pathology-outcomes
#12
Babatunde Olaiya, Charles A Gilliland, Seth D Force, Felix G Fernandez, Manu S Sancheti, William C Small
PURPOSE: In this study, we describe our experience of lesion marking with fiducial markers (FM) and microcoils (MC) facilitating same-day surgical wedge resection, including success rates, pathology outcomes, and complications. We also explored patient/nodular characteristics associated with developing complications. MATERIALS AND METHODS: An IRB-approved single-institutional retrospective study of 136 patients who had 148 pulmonary nodules was conducted. All patients had CT-guided pulmonary nodule labeling with either FM (121) or MC (15) patients with plan for same-day fluoroscopic-guided wedge resection...
November 6, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29179967/-from-tumour-to-tumour-metastasis-of-invasive-ductal-breast-carcinoma-to-chromophobe-renal-cell-carcinoma
#13
Weimar Toro-Zambrano, Áurea Gómez-Durán, Antonio Félix Conde-Martin, Carlos Mayoral-Guisado, Antonio Ruiz-Guerrero, Alejandro Rubio-Fernández
The coexistence of two or more tumours in the same patient is unusual, but even rarer is the metastasis of one tumour to another. Most reports are based on evidence from autopsies; very few refer to surgical specimens. The most common primary tumour is pulmonary carcinoma and most frequent metastatic tumour is renal clear cell carcinoma. We present the case of a 54 year-old female with a past history of infiltrating ductal carcinoma of the breast with metastases in lung, lymph nodes and bone. Three months previously to her referral to us, she had developed a renal mass and underwent nephrectomy...
January 2017: Revista Española de Patología
https://www.readbyqxmd.com/read/29174780/hospitalization-costs-after-surgery-in-high-risk-patients-with-early-stage-lung-cancer
#14
Manu S Sancheti, Ray K Chihara, Sebastian D Perez, Onkar V Khullar, Felix G Fernandez, Allan Pickens, Seth D Force
BACKGROUND: We previously reported that early stage lung cancer patients who are considered high risk for surgery can undergo resection with favorable perioperative results and long-term mortality. To further elucidate the role of surgical resection in this patient cohort, this study evaluated the length of stay and total hospitalization cost among patients classified as standard or high risk with early stage lung cancer who underwent pulmonary resection. METHODS: A total of 490 patients from our institutional Society of Thoracic Surgeons data from 2009 to 2013 underwent resection for clinical stage I lung cancer...
November 23, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29174391/prediction-of-long-term-survival-after-lung-cancer-surgery-for-elderly-patients-in-the-society-of-thoracic-surgeons-general-thoracic-surgery-database
#15
Mark W Onaitis, Anthony P Furnary, Andrzej S Kosinski, Sunghee Kim, Daniel Boffa, Betty C Tong, Patricia Cowper, Jeffrey P Jacobs, Cameron D Wright, Joe B Putnam, Felix G Fernandez
BACKGROUND: Prior risk models using the STS General Thoracic Surgery database (STS-GTSD) have been limited to 30-day outcomes. We have now linked STS data to Medicare data and sought to create a risk prediction model for long-term mortality after lung cancer resection in patients older than 65 years. METHODS: The STS-GTSD was linked to Medicare data for lung cancer resections from 2002 to 2013 as previously reported. Successful linkage was performed in 29,899 lung cancer resection patients...
November 21, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29164877/correction-to-the-discovery-of-novel-antimalarial-aminoxadiazoles-as-a-promising-nonendoperoxide-scaffold
#16
Elena Sandoval, María José Lafuente-Monasterio, María J Almela, Pablo Castañeda, María Belén Jiménez Díaz, María S Martínez-Martínez, Jaume Vidal, Íñigo Angulo-Barturen, Paul Bamborough, Jeremy Burrows, Nicholas Cammack, María J Chaparro, José M Coterón, Cristina de Cozar, Benigno Crespo, Beatriz Díaz, Gerard Drewes, Esther Fernández, Santiago Ferrer-Bazaga, María Teresa Fraile, Francisco J Gamo, Sonja Ghidelli-Disse, Rubén Gómez, John Haselden, Sophie Huss, María Luisa León, Jaime de Mercado, Simon J F Macdonald, José Ignacio Martín Hernando, Sara Prats, Margarita Puente, Anne Rodríguez, Juan C de la Rosa, Lourdes Rueda, Carolyn Selenski, Paul Willis, David M Wilson, Michael Witty, Félix Calderón
No abstract text is available yet for this article.
November 22, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29160074/stereoselective-and-catalytic-synthesis-of-anti-%C3%AE-alkoxy-%C3%AE-azido-carboxylic-derivatives
#17
Javier Fernández-Valparis, Pedro Romea, Fèlix Urpí, Mercè Font-Bardia
Direct addition of a chiral N-azidoacetyl thiazolidinethione to a variety of dialkyl acetals catalyzed by a commercially available and structurally simple nickel(II) complex gives access in good yields and a highly stereocontrolled manner to anti-β-alkoxy-α-azido carboxylic derivatives which, in turn, can be easily converted into a wide array of enantiomerically pure compounds.
November 21, 2017: Organic Letters
https://www.readbyqxmd.com/read/29159325/role-of-aramchol-in-steatohepatitis-and-fibrosis-in-mice
#18
Marta Iruarrizaga-Lejarreta, Marta Varela-Rey, David Fernández-Ramos, Ibon Martínez-Arranz, Teresa C Delgado, Jorge Simon, Virginia Gutiérrez-de Juan, Laura delaCruz-Villar, Mikel Azkargorta, José L Lavin, Rebeca Mayo, Sebastiaan M Van Liempd, Igor Aurrekoetxea, Xabier Buqué, Donatella Delle Cave, Arantza Peña, Juan Rodríguez-Cuesta, Ana M Aransay, Felix Elortza, Juan M Falcón-Pérez, Patricia Aspichueta, Liat Hayardeny, Mazen Noureddin, Arun J Sanyal, Cristina Alonso, Juan Anguita, María Luz Martínez-Chantar, Shelly C Lu, José M Mato
Nonalcoholic steatohepatitis (NASH) is the advanced form of nonalcoholic fatty liver disease (NAFLD) which sets the stage for further liver damage. The mechanism for the progression of NASH involves multiple parallel hits including oxidative stress, mitochondrial dysfunction, inflammation and others. Manipulation of any of these pathways may be an approach to prevent NASH development and progression. Aramchol (arachidyl-amido cholanoic acid) is presently in a phase IIb NASH study. The aim of this study was to investigate Aramchol's mechanism of action and its effect on fibrosis using the methionine- and choline-deficient (MCD) diet model of NASH...
November 2017: Hepatology Communications
https://www.readbyqxmd.com/read/29153787/the-society-of-thoracic-surgeons-national-database-2017-annual-report
#19
Jeffrey P Jacobs, David M Shahian, Richard S D'Agostino, Marshall L Jacobs, Benjamin D Kozower, Vinay Badhwar, Vinod H Thourani, Henning A Gaissert, Felix G Fernandez, Richard L Prager
The Society of Thoracic Surgeons (STS) National Database has three major component databases: the STS Adult Cardiac Surgery Database (ACSD), the STS Congenital Heart Surgery Database (CHSD), and the STS General Thoracic Surgery Database (GTSD). Beginning in January 2016, The Annals of Thoracic Surgery began publishing a monthly series of scholarly articles on outcomes analysis, quality improvement, and patient safety. This article summarizes the status of the STS National Database as of October 2017 and summarizes the articles about the STS National Database that appeared in The Annals of Thoracic Surgery 2017 series "Outcomes Analysis, Quality Improvement, and Patient Safety...
December 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29131205/mechanism-of-enhancement-of-ferroelectricity-of-croconic-acid-with-temperature
#20
Sanghamitra Mukhopadhyay, Matthias J Gutmann, Mónica Jiménez-Ruiz, Dominik B Jochym, Kjartan T Wikfeldt, Keith Refson, Felix Fernandez-Alonso
A detailed study of the thermal behaviour of atomic motions in the organic ferroelectric croconic acid is presented in the temperature range 5-300 K. Using high-resolution inelastic neutron scattering and first-principles electronic-structure calculations within the framework of density functional theory and a quasiharmonic phonon description of the material, we find that the frequencies of the well defined doublet in inelastic neutron scattering spectra associated with out-of-plane motions of hydrogen-bonded protons decrease monotonically with temperature indicating weakening of these bonding motifs and enhancement of proton motions...
November 13, 2017: Physical Chemistry Chemical Physics: PCCP
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