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Felix Fernandez

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https://www.readbyqxmd.com/read/29791289/minimally-invasive-lung-cancer-surgery-performed-by-thoracic-surgeons-as-effective-as-thoracotomy
#1
Daniel J Boffa, Andrzej S Kosinski, Anthony P Furnary, Sunghee Kim, Mark W Onaitis, Betty C Tong, Patricia A Cowper, Jessica R Hoag, Jeffrey P Jacobs, Cameron D Wright, Joe B Putnam, Felix G Fernandez
Purpose The prevalence of minimally invasive lung cancer surgery using video-assisted thoracic surgery (VATS) has increased dramatically over the past decade, yet recent studies have suggested that the lymph node evaluation during VATS lobectomy is inadequate. We hypothesized that the minimally invasive approach to lobectomy for stage I lung cancer resulted in a longitudinal outcome that was not inferior to thoracotomy. Patients and Methods Patients > 65 years of age who had undergone lobectomy for stage I lung cancer between 2002 and 2013 were analyzed within the Society of Thoracic Surgeons General Thoracic Surgery Database, which had been linked to Medicare data, as part of a retrospective-cohort, noninferiority study...
May 23, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29768290/intense-aerobic-exercise-lowers-blood-pressure-in-individuals-with-metabolic-syndrome-taking-antihypertensive-medicine
#2
Miguel Ramirez-Jimenez, Valentin Fernandez-Elias, Felix Morales-Palomo, Juan F Ortega, Ricardo Mora-Rodriguez
OBJECTIVE: There is a growing tendency for physicians to prescribe exercise in accordance with the 'exercise is medicine' global health initiative. However, the exercise-pharmacologic interactions for controlling blood pressure are not well described. Our purpose was to study whether angiotensin II receptor type 1 blocker (ARB) antihypertensive medicine enhances the blood pressure-lowering effects of intense exercise. PARTICIPANTS AND METHODS: Fifteen hypertensive individuals with metabolic syndrome chronically medicated with ARB underwent two exercise trials in a blind randomized order...
May 15, 2018: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/29760372/a-review-of-induction-with-rabbit-antithymocyte-globulin-in-pediatric-heart-transplant-recipients
#3
Martin Schweiger, Andreas Zuckermann, Andres Beiras-Fernandez, Michael Berchtolld-Herz, Udo Boeken, Jens Garbade, Stephan Hirt, Manfred Richter, Arjang Ruhpawar, Jan Dieter Schmitto, Felix Schönrath, Rene Schramm, Uwe Schulz, Markus J Wilhelm, Markus J Barten
Pediatric heart transplantation (pHTx) represents only a small proportion of cardiac transplants. Due to these low numbers, clinical data relating to induction therapy in this special population are far less extensive than for adults. Induction is used more widely in pHTx than in adults, mainly because of early steroid withdrawal or complete steroid avoidance. Antithymocyte globulin (ATG) is the most frequent choice for induction in pHTx, and rabbit antithymocyte globulin (rATG, Thymoglobulin®) (Sanofi Genzyme) is the most widely-used ATG preparation...
May 15, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29722267/recommendations-to-report-and-interpret-hla-genetic-findings-in-coeliac-disease
#4
Concepción Núñez, José Antonio Garrote, Eduardo Arranz, José Ramón Bilbao, Fernando Fernández Bañares, Juana Jiménez, Teresa Perucho, Eva Ruiz Casares, Félix Sánchez-Valverde, Nacho Serrano
Coeliac disease (CD) is a chronic autoimmune enteropathy triggered by gluten and related prolamines in genetically predisposed individuals. Although CD is a polygenic disease, there is a strong association with genes of the human leukocyte antigen (HLA) region. Most patients present the HLA-DQ2 heterodimer, specifically the DQ2.5 isoform, which is present in around 90-96% of patients of European ancestry.
May 3, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29617689/clinical-decision-making-when-treating-diabetic-macular-edema-patients-with-dexamethasone-intravitreal-implants
#5
Alfredo García-Layana, Marta S Figueroa, Luis Arias, Alfredo Adán, Francisco Cabrera, Maximino Abraldes, Álvaro Fernández-Vega, Rafael Navarro, Enrique Cervera, Rufino Silva, Felix Armadá, Juan Donate, José Maria Ruiz-Moreno
Diabetes mellitus (DM) is a metabolic disease frequently associated with comorbidities that include diabetic macular edema (DME). The current medical approach to treating DME involves intravitreal injections with either anti-vascular endothelial growth factors or steroids. However, the burden associated with intravitreal injections and DM-derived complications is high, underlining the need to find optimal treatment regimens. In this article we describe the considerations we apply when treating DME patients with dexamethasone intravitreal implants (Ozurdex®), particularly those that influence the clinical decision-making process during the follow-up period...
April 4, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29589932/synthesis-and-structure-activity-relationships-of-the-novel-antimalarials-5-pyridinyl-4-1-h-pyridones
#6
José M Bueno, Félix Calderon, Jesús Chicharro, Juan C De la Rosa, Beatriz Díaz, Jorge Fernández, José M Fiandor, María T Fraile, Mercedes García, Esperanza Herreros, Adolfo García-Pérez, Milagros Lorenzo, Araceli Mallo, Margarita Puente, Anas Saadeddin, Santiago Ferrer, Iñigo Angulo-Barturen, Jeremy N Burrows, María L León
Malaria is still one of the most prevalent parasitic infections in the world, with half of the world's population at risk for malaria. The effectiveness of current antimalarial therapies, even that of the most recent class of antimalarial drugs (artemisinin-combination therapies, ACTs), is under continuous threat by the spread of resistant Plasmodium strains. As a consequence, there is still an urgent requirement for new antimalarial drugs. We previously reported the identification of 4(1 H)-pyridones as a novel series with potent antimalarial activities...
April 26, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29572086/influence-of-contact-force-on-voltage-mapping-a-combined-magnetic-resonance-imaging-and-electroanatomic-mapping-study-in-patients-with-tetralogy-of-fallot
#7
Elvis Teijeira-Fernandez, Hubert Cochet, Felix Bourier, Masateru Takigawa, Ghassen Cheniti, Nathaniel Thompson, Antonio Frontera, Claudia Camaioni, Gregoire Massouille, Zakaria Jalal, Nicolas Derval, Xavier Iriart, Arnaud Denis, Meleze Hocini, Michel Haissaguerre, Pierre Jais, Jean-Benoit Thambo, Frederic Sacher
BACKGROUND: Voltage criteria for ventricular mapping have been obtained from small series of patients and prioritizing high specificity. OBJECTIVE: Using tetralogy of Fallot as a model of transmural right ventricular (RV) scar and MRI as reference, we aimed to study the potential influence of contact force (CF) on voltage mapping and to define voltage cutoff values for RV scar. METHODS: Fourteen patients (age 32.6±14.3, 5 female) with repaired tetralogy of Fallot underwent high resolution cardiac MRI (1...
March 20, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29571592/risk-of-maternal-mortality-in-women-with-severe-anaemia-during-pregnancy-and-post-partum-a-multilevel-analysis
#8
Jahnavi Daru, Javier Zamora, Borja M Fernández-Félix, Joshua Vogel, Olufemi T Oladapo, Naho Morisaki, Özge Tunçalp, Maria Regina Torloni, Suneeta Mittal, Kapila Jayaratne, Pisake Lumbiganon, Ganchimeg Togoobaatar, Shakila Thangaratinam, Khalid S Khan
BACKGROUND: Anaemia affects as many as half of all pregnant women in low-income and middle-income countries, but the burden of disease and associated maternal mortality are not robustly quantified. We aimed to assess the association between severe anaemia and maternal death with data from the WHO Multicountry Survey on maternal and newborn health. METHODS: We used multilevel and propensity score regression analyses to establish the relation between severe anaemia and maternal death in 359 health facilities in 29 countries across Latin America, Africa, the Western Pacific, eastern Mediterranean, and southeast Asia...
May 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29570428/intravascular-cooling-catheter-related-venous-thromboembolism-after-hypothermia-a-case-report-and-review-of-the-literature
#9
Xuan Wang, Brian T Moy, Brett J Hiendlmayr, Felix Krainski, W Lane Duvall, Antonio B Fernandez
Fifty-four year-old man with recent history of myocardial infarction and a percutaneous coronary intervention who suffered a ventricular fibrillation arrest at home. He was resuscitated in the field. His heart rhythm was in atrial fibrillation. The cardiac catheterization showed a patent stent from his previous myocardial infarction and no new occlusions. He subsequently underwent hypothermia protocol using the Alsius CoolGard 3000 Temperature Control System and Icy Catheter. Heparin drip was started for atrial fibrillation 36 hours after catheter insertion and became therapeutic 2 hours before the end of cooling maintenance phase...
March 23, 2018: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/29547439/high-grade-anal-intraepithelial-neoplasia-is-associated-with-hiv-1-rna-rectal-shedding-in-virologically-suppressed-msm
#10
Elena García-Payá, Marta Fernández, Sergio Padilla, José A García, Catalina Robledano, Victoria Ortiz de la Tabla, Félix Gutiérrez, Mar Masiá
OBJECTIVE: The protective effect of ART has not yet been definitively established in MSM. We aimed to characterize the factors associated with persistent HIV-1 RNA rectal shedding. METHODS: Prospective study including virologically suppressed MSM from an HIV cohort. High-resolution anoscopy (HRA) was performed for screening of anal dysplasia, and rectal sampling for HIV-1 RNA quantification and sexually transmitted infections (STIs) investigation through multiplex PCR...
May 15, 2018: AIDS
https://www.readbyqxmd.com/read/29538515/-notebooks-on-health-and-work-diaries-of-public-university-professors
#11
Katia Reis de Souza, Verônica Silva Fernandez, Liliane Reis Teixeira, Ariane Leites Larentis, André Luis de Oliveira Mendonça, Eliana Guimarães Felix, Maria Blandina Marques Dos Santos, Andrea Maria Dos Santos Rodrigues, Marisa Moura, Regina Helena Simões-Barbosa, Walcyr de Oliveira Barros, Mariza Gomes de Almeida
The main objective of this article is to present and analyze the research instrument called "health and work notebooks", focusing on the production of knowledge concerning professors' work at a public university. The notebooks serve as a qualitative and participant research technique that is appropriate for the in-depth study of relations between health and work, viewing workplaces as privileged spaces for exercising effective action in the defense of health and the work experience as the principal material for analysis...
March 8, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29530988/deletion-of-the-cold-thermoreceptor-trpm8-increases-heat-loss-and-food-intake-leading-to-reduced-body-temperature-and-obesity-in-mice
#12
Alfonso Reimúndez, Carlos Fernández-Peña, Guillermo García, Rubén Fernández, Purificación Ordás, Rosalía Gallego, Jose L Pardo-Vazquez, Victor Arce, Félix Viana, Rosa Señarís
The coupling of energy homeostasis to thermoregulation is essential to maintain homeothermy in changing external environments. We studied the role of the cold thermoreceptor TRPM8 in this interplay in mice of both sexes. We demonstrate that TRPM8 is required for a precise thermoregulation in response to cold, in fed and fasting. Trpm8 -/- mice exhibited a fall of 0.7°C in core body temperature when housed at cold temperatures, and a deep hypothermia (<30°C) during food deprivation. In both situations, TRPM8 deficiency induced an increase in tail heat loss...
April 11, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29529472/construct-validity-and-parent-child-agreement-of-the-six-new-or-modified-disorders-included-in-the-spanish-version-of-the-kiddie-schedule-for-affective-disorders-and-schizophrenia-present-and-lifetime-version-dsm-5-k-sads-pl-5
#13
Francisco R de la Peña, Marcos F Rosetti, Andrés Rodríguez-Delgado, Lino R Villavicencio, Juan D Palacio, Cecilia Montiel, Pablo A Mayer, Fernando J Félix, Marcela Larraguibel, Laura Viola, Silvia Ortiz, Sofía Fernández, Aurora Jaímes, Miriam Feria, Liz Sosa, Lino Palacios-Cruz, Rosa E Ulloa
Changes to the Diagnostic and Statistical Manual of Mental Disorders fifth edition (DSM-5) incorporate the inclusion or modification of six disorders: Autism Spectrum Disorder, Social Anxiety Disorder, Intermittent Explosive Disorder, Disruptive Mood Dysregulation Disorder, Avoidant/Restrictive Food Intake Disorder and Binge Eating Disorder. The objectives of this study were to assess the construct validity and parent-child agreement of these six disorders in the Spanish language Schedule for Affective Disorders and Schizophrenia for School Age Children Present and Lifetime Version (K-SADS-PL-5) in a clinical population of children and adolescents from Latin America...
June 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29529191/overview-of-mitral-regurgitation-in-europe-results-from-the-european-registry-of-mitral-regurgitation-eumiclip
#14
Juan Manuel Monteagudo Ruiz, Maurizio Galderisi, Agostino Buonauro, Luigi Badano, Patrizia Aruta, Martin J Swaans, Laura Sanchis, Antti Saraste, Mark Monaghan, Konstantinos C Theodoropoulos, Michael Papitsas, Noah Liel-Cohen, Sergio Kobal, Mojca Bervar, Boštjan Berlot, Gerasimos Filippatos, Ignatios Ikonomidis, Spyridon Katsanos, Felix C Tanner, Daniela Cassani, Francesco F Faletra, Laura A Leo, Amparo Martinez, Javier Matabuena, Antonio Grande-Trillo, David Alonso-Rodriguez, Dolores Mesa, Teresa Gonzalez-Alujas, Marta Sitges, Fernando Carrasco-Chinchilla, Chi Hion Li, Covadonga Fernandez-Golfin, José Luis Zamorano
Aims: To determine the prevalence of mitral regurgitation (MR) in a large cohort of consecutive patients undergoing clinically indicated echocardiography and to examine the distribution of primary and secondary MR. Methods and results: All patients undergoing an echocardiographic study in 19 European centres within a 3-month period were prospectively included. MR assessment was performed as recommended by the European Association of Cardiovascular Imaging (EACVI)...
February 23, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29518386/the-society-of-thoracic-surgeons-general-thoracic-surgery-database-2018-update-on-outcomes-and-quality
#15
Christopher W Seder, Daniel Raymond, Cameron D Wright, Henning A Gaissert, Andrew C Chang, Susan Becker, Varun Puri, Robert Welsh, William Burfeind, Felix G Fernandez, Lisa M Brown, Benjamin D Kozower
For nearly 15 years The Society of Thoracic Surgeons General Thoracic Surgery Database (STS GTSD) has provided participating institutions with risk-adjusted feedback reports that allow outcome comparisons relative to national benchmarks. With more than 300 contributing centers across North America, the STS GTSD now includes more than 530,000 cases. In 2017 the STS GTSD Task Force revised the data collection form with the goal of collecting more detailed and accurate information for the most important thoracic surgical cases without increasing the workload of registrars...
May 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29508444/evaluation-of-the-virclia-%C3%A2-automated-chemiluminescent-immunoassay-system-for-diagnosing-pneumonia-caused-by-mycoplasma-pneumoniae
#16
Victoria Ortiz de la Tabla, Marta Berruezo, Elena García Payá, Marta Fernández, José Alberto García, Mar Masiá, Félix Gutiérrez
BACKGROUND: Mycoplasma pneumoniae is considered an important etiologic agent of community-acquired pneumonia (CAP) in outpatients. We aimed to evaluate the diagnostic accuracy of a quick automated chemiluminescent immunoassay (CLIA) for M. pneumoniae in a population-based prospective study of CAP. METHODS: A total of 137 outpatients diagnosed with CAP were included in the study. Acute- and convalescent phase sera were analyzed for IgG and IgM to M. pneumoniae with both CLIA (VirClia® ) and ELISA immunoassays...
March 6, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29507185/lxr-nuclear-receptors-are-transcriptional-regulators-of-dendritic-cell-chemotaxis
#17
Susana Beceiro, Attila Pap, Zsolt Czimmerer, Tamer Sallam, Jose A Guillén, Germán Gallardo, Cynthia Hong, Noelia A-Gonzalez, Carlos Tabraue, Mercedes Diaz, Felix Lopez, Jonathan Matalonga, Annabel F Valledor, Pilar Dominguez, Carlos Ardavin, Cristina Delgado-Martin, Santiago Partida-Sanchez, Jose Luis Rodriguez-Fernandez, Laszlo Nagy, Peter Tontonoz, Antonio Castrillo
The liver X receptors (LXRs) are ligand-activated nuclear receptors with established roles in the maintenance of lipid homeostasis in multiple tissues. LXRs exert additional biological functions as negative regulators of inflammation, particularly in macrophages. However, the transcriptional responses controlled by LXRs in other myeloid cells, such as dendritic cells (DC), are still poorly understood. Here we used gain- and loss-of-function models to characterize the impact of LXR deficiency on DC activation programs...
March 5, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29489472/development-and-validation-of-a-scoring-index-to-predict-the-presence-of-lesions-in-capsule-endoscopy-in-patients-with-suspected-crohn-s-disease-of-the-small-bowel-a-spanish-multicenter-study
#18
Juan Egea-Valenzuela, Begoña González Suárez, Cristian Sierra Bernal, José Francisco Juanmartiñena Fernández, Marisol Luján-Sanchís, Mileidis San Juan Acosta, Blanca Martínez Andrés, Vicente Pons Beltrán, Violeta Sastre Lozano, Cristina Carretero Ribón, Félix de Vera Almenar, Joaquín Sánchez Cuenca, Fernando Alberca de Las Parras, Cristina Rodríguez de Miguel, Julio Valle Muñoz, Ignacio Férnandez-Urién Sainz, Carolina Torres González, Pilar Borque Barrera, Enrique Pérez-Cuadrado Robles, Noelia Alonso Lázaro, Pilar Martínez García, César Prieto de Frías, Fernando Carballo Álvarez
BACKGROUND: Capsule endoscopy (CE) is the first-line investigation in cases of suspected Crohn's disease (CD) of the small bowel, but the factors associated with a higher diagnostic yield remain unclear. OBJECTIVE: Our aim is to develop and validate a scoring index to assess the risk of the patients in this setting on the basis of biomarkers. PATIENTS AND METHODS: Data on fecal calprotectin, C-reactive protein, and other biomarkers from a population of 124 patients with suspected CD of the small bowel studied by CE and included in a PhD study were used to build a scoring index...
May 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29483057/an-autochthonous-confirmed-case-of-rickettsia-parkeri-rickettsiosis-in-uruguay
#19
Álvaro A Faccini-Martínez, María L Félix, María T Armua-Fernandez, José M Venzal
Rickettsia parkeri, a member of the spotted fever group (SFG) rickettsiae, was first confirmed as an etiological agent of human rickettsiosis in 2004. Nearly all cases are characterized by an inoculation eschar, and no fatalities have been reported. In Uruguay, probable human cases of R. parkeri infection (confused initially with R. conorii infection) have been described since 1990 using the clinical name "cutaneous-ganglionar" rickettsiosis. This is the only tick-borne rickettsiosis reported in the country...
March 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29475656/low-prevalence-of-microplastic-contamination-in-planktivorous-fish-species-from-the-southeast-pacific-ocean
#20
Nicolas Ory, Catherine Chagnon, Fernando Felix, César Fernández, Joana Lia Ferreira, Camila Gallardo, Ostin Garcés Ordóñez, Aida Henostroza, Enrique Laaz, Ricardo Mizraji, Hermes Mojica, Vladimir Murillo Haro, Luis Ossa Medina, Mercy Preciado, Paula Sobral, Mauricio A Urbina, Martin Thiel
The gut contents of 292 planktivorous fish, from four families (Atherinopsidae, Clupeidae, Engraulidae and Scombridae) and seven species, captured along the coast of the southeast Pacific, were examined for microplastic contamination. Only a small fraction of all studied fish (2.1%; 6 individuals) contained microplastic particles in their digestive tract. Microplastics found were degraded hard fragments and threads, ranging from 1.1 to 4.9 (3.8±SD 2.4) mm in length, and of various colours, which suggests that the planktivorous fish species examined herein did not capture microplastics on the basis of their colour...
February 2018: Marine Pollution Bulletin
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