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Felix Fernandez

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https://www.readbyqxmd.com/read/28530708/engineering-rgb-color-vision-into-escherichia-coli
#1
Jesus Fernandez-Rodriguez, Felix Moser, Miryoung Song, Christopher A Voigt
Optogenetic tools use colored light to rapidly control gene expression in space and time. We designed a genetically encoded system that gives Escherichia coli the ability to distinguish between red, green, and blue (RGB) light and respond by changing gene expression. We use this system to produce 'color photographs' on bacterial culture plates by controlling pigment production and to redirect metabolic flux by expressing CRISPRi guide RNAs.
May 22, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28530702/metformin-alters-the-gut-microbiome-of-individuals-with-treatment-naive-type-2-diabetes-contributing-to-the-therapeutic-effects-of-the-drug
#2
Hao Wu, Eduardo Esteve, Valentina Tremaroli, Muhammad Tanweer Khan, Robert Caesar, Louise Mannerås-Holm, Marcus Ståhlman, Lisa M Olsson, Matteo Serino, Mercè Planas-Fèlix, Gemma Xifra, Josep M Mercader, David Torrents, Rémy Burcelin, Wifredo Ricart, Rosie Perkins, José Manuel Fernàndez-Real, Fredrik Bäckhed
Metformin is widely used in the treatment of type 2 diabetes (T2D), but its mechanism of action is poorly defined. Recent evidence implicates the gut microbiota as a site of metformin action. In a double-blind study, we randomized individuals with treatment-naive T2D to placebo or metformin for 4 months and showed that metformin had strong effects on the gut microbiome. These results were verified in a subset of the placebo group that switched to metformin 6 months after the start of the trial. Transfer of fecal samples (obtained before and 4 months after treatment) from metformin-treated donors to germ-free mice showed that glucose tolerance was improved in mice that received metformin-altered microbiota...
May 22, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28528882/mortality-and-atrial-fibrillation-in-the-fiaca-study-evidence-of-a-differential-effect-according-to-admission-diagnosis
#3
Francisco Guillermo Clavel-Ruipérez, Luciano Consuegra-Sánchez, Francisco Javier Félix Redondo, Luis Lozano Mera, Pedro Mellado-Delgado, Juan José Martínez-Díaz, José Ramón López Mínguez, Daniel Fernández-Bergés
INTRODUCTION AND OBJECTIVES: Atrial fibrillation (AF) is an independent risk factor for mortality in several diseases. However, data published in acute decompensated heart failure (DHF) are contradictory. Our objective was to investigate the impact of AF on mortality in patients admitted to hospital for DHF compared with those admitted for other reasons. METHODS: This retrospective cohort study included all patients admitted to hospital within a 10-year period due to DHF, acute myocardial infarction (AMI), or ischemic stroke (IS), with a median follow-up of 6...
May 18, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28527969/surgically-managed-clinical-stage-iiia-clinical-n2-lung-cancer-in-the%C3%A2-society-of-thoracic-surgeons-database
#4
Daniel Boffa, Felix G Fernandez, Sunghee Kim, Andrzej Kosinski, Mark W Onaitis, Patricia Cowper, Jeffrey P Jacobs, Cameron D Wright, Joe B Putnam, Anthony P Furnary
BACKGROUND: The role of surgical resection in patients with clinical stage IIIA-N2 positive (cIIIA-N2) lung cancer is controversial, partly because of the variability in short- and long-term outcomes. The objective of this study was to characterize the management of cIIIA-N2 lung cancer in The Society of Thoracic Surgeons General Thoracic Surgery Database (STS-GTSD). METHODS: The STS-GTSD was queried for patients who underwent operations for cIIIA-N2 lung cancer between 2002 and 2012...
May 17, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28503009/performance-of-metal-and-polymeric-o-ring-seals-during-beyond-design-basis-thermal-conditions
#5
Jiann C Yang, Edward Hnetkovsky, Doris Rinehart, Marco Fernandez, Felix Gonzalez, Joseph Borowsky
This paper summarizes the small scale thermal exposure test results of the performance of metallic and polymeric O-ring seals typically used in radioactive material transportation packages. Five different O-ring materials were evaluated: Inconel/silver, ethylene-propylene diene monomer (EPDM), polytetrafluoroethylene (PTFE), silicone, butyl, and Viton. The overall objective of this study is to provide test data and insights to the performance of these Oring seals when exposed to beyond-design-basis temperature conditions due to a severe fire...
April 2017: Polymer Testing
https://www.readbyqxmd.com/read/28483154/pilot-study-to-integrate-patient-reported-outcomes-after-lung-cancer-operations-into-the-society-of-thoracic-surgeons-database
#6
Onkar V Khullar, Mohammed H Rajaei, Seth D Force, Jose N Binongo, Yi Lasanajak, Scott Robertson, Allan Pickens, Manu S Sancheti, Joseph Lipscomb, Theresa W Gillespie, Felix G Fernandez
BACKGROUND: A critical gap in The Society of Thoracic Surgeons (STS) Database is the absence of patient-reported outcomes (PRO), which are of increasing importance in outcomes and performance measurement. Our aim was to demonstrate the feasibility of integrating PRO into the STS Database for patients undergoing lung cancer operations. METHODS: The National Institutes of Health Patient Reported Outcome Measurement Information System (PROMIS) includes reliable, precise measures of PRO...
May 5, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28474341/effects-of-preoperative-dexamethasone-on-postoperative-pain-nausea-vomiting-and-respiratory-function-in-women-undergoing-conservative-breast-surgery-for-cancer-results-of-a%C3%A2-controlled-clinical-trial
#7
A O Cortés-Flores, J Jiménez-Tornero, G Morgan-Villela, M Delgado-Gómez, C J Zuloaga-Fernández Del Valle, J García-Rentería, J Rendón-Félix, C Fuentes-Orozco, M D Macías-Amezcua, G Ambriz-González, A S Alvarez-Villaseñor, D Urias-Valdez, M Chavez-Tostado, G I Contreras-Hernández, A González-Ojeda
The objective was to evaluate whether preoperative administration of dexamethasone improved postoperative nausea and vomiting (PONV), pain and respiratory function tests in women undergoing conservative surgery for breast cancer. This was a controlled clinical trial conducted between June 2013 and October 2014. Eighty patients were evaluated. Patients received a preoperative dose of 8 mg of dexamethasone (n = 40) or placebo (n = 40). The data on PONV and pain intensity was obtained and forced spirometry tests were performed, 1 hr before and at 1, 6, 12 and 24 hr after surgery...
May 4, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28464264/concurrent-chemoradiotherapy-with-or-without-surgery-for-patients-with-resectable-esophageal-cancer-an-analysis-of-the-national-cancer-data-base
#8
Kushal B Naik, Yuan Liu, Michael Goodman, Theresa W Gillespie, Allan Pickens, Seth D Force, Conor E Steuer, Taofeek K Owonikoko, Suresh S Ramalingam, Kristin Higgins, Jonathan J Beitler, Dong M Shin, Field F Willingham, Bassel El-Rayes, Jerome C Landry, Felix G Fernandez, Nabil F Saba
BACKGROUND: Patients with resectable esophageal cancer (rEC) are managed with either concurrent chemoradiotherapy followed by surgery (CRSx) or concurrent chemoradiotherapy alone (cCR). To the authors' knowledge, there is insufficient evidence comparing the overall survival of patients treated with these 2 options. METHODS: The National Cancer Data Base was queried for rEC cases diagnosed from 2003 through 2011. Patients with previous cancers, cervical rEC, clinical stage T1N0 disease, or metastasis were excluded...
May 2, 2017: Cancer
https://www.readbyqxmd.com/read/28439553/maximizing-the-performance-of-photothermal-actuators-by-combining-smart-materials-with-supplementary-advantages
#9
Tongyu Wang, David Torres, Félix E Fernández, Chuan Wang, Nelson Sepúlveda
The search for higher-performance photothermal microactuators has typically involved unavoidable trade-offs that hinder the demonstration of ubiquitous devices with high energy density, speed, flexibility, efficiency, sensitivity, and multifunctionality. Improving some of these parameters often implies deterioration of others. Photothermal actuators are driven by the conversion of absorbed optical energy into thermal energy, which, by different mechanisms, can produce mechanical displacement of a structure...
April 2017: Science Advances
https://www.readbyqxmd.com/read/28436984/genomic-analyses-identify-hundreds-of-variants-associated-with-age-at-menarche-and-support-a-role-for-puberty-timing-in-cancer-risk
#10
Felix R Day, Deborah J Thompson, Hannes Helgason, Daniel I Chasman, Hilary Finucane, Patrick Sulem, Katherine S Ruth, Sean Whalen, Abhishek K Sarkar, Eva Albrecht, Elisabeth Altmaier, Marzyeh Amini, Caterina M Barbieri, Thibaud Boutin, Archie Campbell, Ellen Demerath, Ayush Giri, Chunyan He, Jouke J Hottenga, Robert Karlsson, Ivana Kolcic, Po-Ru Loh, Kathryn L Lunetta, Massimo Mangino, Brumat Marco, George McMahon, Sarah E Medland, Ilja M Nolte, Raymond Noordam, Teresa Nutile, Lavinia Paternoster, Natalia Perjakova, Eleonora Porcu, Lynda M Rose, Katharina E Schraut, Ayellet V Segrè, Albert V Smith, Lisette Stolk, Alexander Teumer, Irene L Andrulis, Stefania Bandinelli, Matthias W Beckmann, Javier Benitez, Sven Bergmann, Murielle Bochud, Eric Boerwinkle, Stig E Bojesen, Manjeet K Bolla, Judith S Brand, Hiltrud Brauch, Hermann Brenner, Linda Broer, Thomas Brüning, Julie E Buring, Harry Campbell, Eulalia Catamo, Stephen Chanock, Georgia Chenevix-Trench, Tanguy Corre, Fergus J Couch, Diana L Cousminer, Angela Cox, Laura Crisponi, Kamila Czene, George Davey Smith, Eco J C N de Geus, Renée de Mutsert, Immaculata De Vivo, Joe Dennis, Peter Devilee, Isabel Dos-Santos-Silva, Alison M Dunning, Johan G Eriksson, Peter A Fasching, Lindsay Fernández-Rhodes, Luigi Ferrucci, Dieter Flesch-Janys, Lude Franke, Marike Gabrielson, Ilaria Gandin, Graham G Giles, Harald Grallert, Daniel F Gudbjartsson, Pascal Guénel, Per Hall, Emily Hallberg, Ute Hamann, Tamara B Harris, Catharina A Hartman, Gerardo Heiss, Maartje J Hooning, John L Hopper, Frank Hu, David J Hunter, M Arfan Ikram, Hae Kyung Im, Marjo-Riitta Järvelin, Peter K Joshi, David Karasik, Manolis Kellis, Zoltan Kutalik, Genevieve LaChance, Diether Lambrechts, Claudia Langenberg, Lenore J Launer, Joop S E Laven, Stefania Lenarduzzi, Jingmei Li, Penelope A Lind, Sara Lindstrom, YongMei Liu, Jian'an Luan, Reedik Mägi, Arto Mannermaa, Hamdi Mbarek, Mark I McCarthy, Christa Meisinger, Thomas Meitinger, Cristina Menni, Andres Metspalu, Kyriaki Michailidou, Lili Milani, Roger L Milne, Grant W Montgomery, Anna M Mulligan, Mike A Nalls, Pau Navarro, Heli Nevanlinna, Dale R Nyholt, Albertine J Oldehinkel, Tracy A O'Mara, Sandosh Padmanabhan, Aarno Palotie, Nancy Pedersen, Annette Peters, Julian Peto, Paul D P Pharoah, Anneli Pouta, Paolo Radice, Iffat Rahman, Susan M Ring, Antonietta Robino, Frits R Rosendaal, Igor Rudan, Rico Rueedi, Daniela Ruggiero, Cinzia F Sala, Marjanka K Schmidt, Robert A Scott, Mitul Shah, Rossella Sorice, Melissa C Southey, Ulla Sovio, Meir Stampfer, Maristella Steri, Konstantin Strauch, Toshiko Tanaka, Emmi Tikkanen, Nicholas J Timpson, Michela Traglia, Thérèse Truong, Jonathan P Tyrer, André G Uitterlinden, Digna R Velez Edwards, Veronique Vitart, Uwe Völker, Peter Vollenweider, Qin Wang, Elisabeth Widen, Ko Willems van Dijk, Gonneke Willemsen, Robert Winqvist, Bruce H R Wolffenbuttel, Jing Hua Zhao, Magdalena Zoledziewska, Marek Zygmunt, Behrooz Z Alizadeh, Dorret I Boomsma, Marina Ciullo, Francesco Cucca, Tõnu Esko, Nora Franceschini, Christian Gieger, Vilmundur Gudnason, Caroline Hayward, Peter Kraft, Debbie A Lawlor, Patrik K E Magnusson, Nicholas G Martin, Dennis O Mook-Kanamori, Ellen A Nohr, Ozren Polasek, David Porteous, Alkes L Price, Paul M Ridker, Harold Snieder, Tim D Spector, Doris Stöckl, Daniela Toniolo, Sheila Ulivi, Jenny A Visser, Henry Völzke, Nicholas J Wareham, James F Wilson, Amanda B Spurdle, Unnur Thorsteindottir, Katherine S Pollard, Douglas F Easton, Joyce Y Tung, Jenny Chang-Claude, David Hinds, Anna Murray, Joanne M Murabito, Kari Stefansson, Ken K Ong, John R B Perry
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project-imputed genotype data in up to ∼370,000 women, we identify 389 independent signals (P < 5 × 10(-8)) for age at menarche, a milestone in female pubertal development. In Icelandic data, these signals explain ∼7.4% of the population variance in age at menarche, corresponding to ∼25% of the estimated heritability. We implicate ∼250 genes via coding variation or associated expression, demonstrating significant enrichment in neural tissues...
April 24, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28431693/the-society-of-thoracic-surgeons-general-thoracic-surgery-database-2017-update-on-outcomes-and-quality
#11
Christopher W Seder, Daniel P Raymond, Cameron D Wright, Henning A Gaissert, Andrew C Chang, Sydney Clinton, Susan Becker, Felix G Fernandez, Benjamin D Kozower
The Society of Thoracic Surgeons General Thoracic Surgery Database (STS GTSD) is a voluntary effort that provides participants with risk-adjusted semiannual performance reports that allow comparison of institutional outcomes against national benchmarks. With nearly 1,000 surgeons contributing data from more than 300 centers across North America, the STS GTSD now includes almost a half million cases. In 2016, updated risk models for lung resection and esophagectomy for cancer were reported, and composite quality measures for lobectomy and esophagectomy were developed...
May 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28385923/phenotype-of-mutations-in-the-promoter-region-of-the-%C3%AE-globin-gene
#12
Paloma Ropero, Sara Erquiaga, Beatriz Arrizabalaga, Germán Pérez, Silvia de la Iglesia, María José Torrejón, Celia Gil, Cela Elena, María Tenorio, Jorge M Nieto, Félix de la Fuente-Gonzalo, Ana Villegas, Fernando-Ataúlfo González Fernández, Rafael Martínez
BACKGROUND: β(+)-Thalassaemia is characterised by reduced production of β chains, which decrease can be caused by mutations in the promoter region (CACCC or TATA box), and is classified as mild or silent depending on the extent of β-globin chain reduction. In both cases, homozygotes or compound heterozygotes for these mutations usually have thalassaemia intermedia. Frequently the diagnosis is made in adulthood or even in old age. A total of 37 alterations in the promoter region have been described so far...
April 6, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28373068/stereotactic-body-radiotherapy-for-early-stage-non-small-cell-lung-cancer-in-patients-80-years-and-older-a-multi-center-analysis
#13
Richard J Cassidy, Pretesh R Patel, Xinyan Zhang, Robert H Press, Jeffrey M Switchenko, Rathi N Pillai, Taofeek K Owonikoko, Suresh S Ramalingam, Felix G Fernandez, Seth D Force, Walter J Curran, Kristin A Higgins
BACKGROUND: Stereotactic body radiotherapy (SBRT) is the standard of care for medically inoperable early-stage non-small-cell lung cancer. Despite the limited number of octogenarians and nonagenarians on trials of SBRT, its use is increasingly being offered in these patients, given the aging cancer population, medical fragility, or patient preference. Our purpose was to investigate the efficacy, safety, and survival of patients ≥ 80 years old treated with definitive lung SBRT. METHODS: Patients who underwent SBRT were reviewed from 2009 to 2015 at 4 academic centers...
March 16, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28363375/prosthetic-reconstruction-of-the-chest-wall
#14
REVIEW
Onkar V Khullar, Felix G Fernandez
Large chest wall resections can result in skeletal instability, altered respiratory mechanics, and significant cosmetic defects. Here the authors review a variety of prostheses that can be used to reconstruct these defects, the indications for their use, the technique for implantation, and the available data regarding their clinical outcomes.
May 2017: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/28332732/spanish-version-of-the-mattis-dementia-rating-scale-2-for-early-detection-of-alzheimer-s-disease-and-mild-cognitive-impairment
#15
Elina Boycheva, Israel Contador, Bernardino Fernández-Calvo, Francisco Ramos-Campos, Verónica Puertas-Martín, Alberto Villarejo-Galende, Félix Bermejo-Pareja
OBJECTIVE: We aimed to analyse the clinical utility of the Mattis Dementia Rating Scale (MDRS-2) for early detection of Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) in a sample of Spanish older adults. METHODS: A total of 125 participants (age = 75.12 ± 6.83, years of education =7.08 ± 3.57) were classified in three diagnostic groups: 45 patients with mild AD, 37 with amnestic MCI-single and multiple domain and 43 cognitively healthy controls (HCs)...
March 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28304035/nuclear-dynamics-and-phase-polymorphism-in-solid-formic-acid
#16
Maciej Krzystyniak, Kacper Drużbicki, Giovanni Romanelli, Matthias J Gutmann, Svemir Rudić, Silvia Imberti, Felix Fernandez-Alonso
We apply a unique sequence of structural and dynamical neutron-scattering techniques, augmented with density-functional electronic-structure calculations, to establish the degree of polymorphism in an archetypal hydrogen-bonded system - crystalline formic acid. Using this combination of experimental and theoretical techniques, the hypothesis by Zelsmann on the coexistence of the β1 and β2 phases above 220 K is tested. Contrary to the postulated scenario of proton-transfer-driven phase coexistence, the emerging picture is one of a quantitatively different structural change over this temperature range, whereby the loosening of crystal packing promotes temperature-induced shearing of the hydrogen-bonded chains...
March 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28301455/-characteristics-of-communication-systems-of-suspected-occupational-disease-in-the-autonomous-communities-spain
#17
Montserrat García Gómez, Félix Urbaneja Arrúe, Vega García López, Valentín Estaban Buedo, Valentín Rodríguez Suárez, Lourdes Miralles Martínez-Portillo, Isabel González García, Josefa Egea Garcia, Emma Corraliza Infanzon, Laura Ramírez Salvador, Santiago Briz Blázquez, Ricard Armengol Rosell, José María Cisnal Gredilla, Juan Francisco Correa Rodríguez, Juan Carlos Coto Fernández, Mª Rosario Díaz Peral, Mercedes Elvira Espinosa, Iñigo Fernández Fernández, Eduardo García-Ramos Alonso, Nieves Martínez Arguisuelas, Ana Isabel Rivas Pérez
BACKGROUND: There are several initiatives to develop systems for the notification of suspected occupational disease (OD) in different autonomous communities. The objective was to describe the status of development and characteristics of these systems implemented by the health authorities. METHODS: A cross-sectional descriptive study was carried out on the existence of systems for the information and surveillance of suspected OD, their legal framework, responsible institution and availability of information...
March 17, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28267888/role-of-hla-dp-and-hla-dq-on-the-clearance-of-hepatitis-b-virus-and-the-risk-of-chronic-infection-in-a-multiethnic-population
#18
Julieta Trinks, Nao Nishida, María Laura Hulaniuk, Mariela Caputo, Takayo Tsuchiura, Sebastián Marciano, Leila Haddad, Jorgelina Blejer, Sonia Bartoli, Beatriz Ameigeiras, Silvia E Frías, Cecilia Vistarini, Fabiana Heinrich, Carlos Remondegui, Susana Ceballos, Gustavo Echenique, Miguel Charre Samman, Claudia D'Amico, Amalia Rojas, Alfredo Martínez, Ezequiel Ridruejo, Roberto J Fernández, Leandro Burgos Pratx, Horacio Salamone, Félix Nuñez, Omar Galdame, Adrián Gadano, Daniel Corach, Masaya Sugiyama, Diego Flichman, Katsushi Tokunaga, Masashi Mizokami
BACKGROUND & AIMS: HBV infection exhibits geographical variation in its distribution in South America. While HBV rates are low in central Argentina, the north-western region exhibits intermediate HBV rates. Unfortunately, the reasons that could explain this difference are still unknown. METHODS: A total of 1440 Argentines were recruited and grouped into HBV patients, HBV-resolved individuals and healthy controls. Genetic ancestry was assessed by analysis of biparental lineages and ancestry autosomal typing...
March 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28249357/gastrulation-in-an-annual-killifish-molecular-and-cellular-events-during-germ-layer-formation-in-austrolebias
#19
Luisa Pereiro, Felix Loosli, Juan Fernández, Steffen Härtel, Joachim Wittbrodt, Miguel L Concha
BACKGROUND: Comparative studies beyond the traditional model organisms have been instrumental in enhancing our understanding of the conserved and derived features of gastrulation, a fundamental process in which the germ layers are specified and shaped to form the body axis. Here, we analysed gastrulation in a vertebrate group with an extreme mode of early development, the annual killifish. RESULTS: Gastrulation in annual killifish of the genus Austrolebias takes place after the initially dispersed deep blastomeres congregate to form the so-called reaggregate...
March 1, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28219550/invited-commentary
#20
Felix G Fernandez
No abstract text is available yet for this article.
March 2017: Annals of Thoracic Surgery
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