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Felix Fernandez

Henning A Gaissert, Felix G Fernandez, Mark S Allen, William R Burfeind, Mark I Block, James M Donahue, John D Mitchell, Paul H Schipper, Mark W Onaitis, Andrzej S Kosinski, Jeffrey P Jacobs, David M Shahian, Benjamin D Kozower, Fred H Edwards, Emily A Conrad, G Alexander Patterson
The Society of Thoracic Surgeons General Thoracic Surgery Database has grown to more than 500,000 case records. Clinical research supported by the database is increasingly used to advance patient outcomes. This research review from the General Thoracic Surgery Database in 2014 and 2015 discusses 6 recent publications and an ongoing study on longitudinal outcomes in lung cancer surgery from The Society of Thoracic Surgeons Task Force for Linked Registries and Longitudinal Follow-up. A lack of database variables specific for certain uncommon procedures limits the ability to study these operations; inclusion of clinical descriptors for selected infrequent but clinically important thoracic disorders is suggested...
November 2016: Annals of Thoracic Surgery
Félix Zapata, Mª Ángeles Fernández de la Ossa, Elizabeth Gilchrist, Leon Barron, Carmen García-Ruiz
Concerning the dreadful global threat of terrorist attacks, the detection of explosive residues in biological traces and marks is a current need in both forensics and homeland security. This study examines the potential of Raman microscopy in comparison to liquid chromatography (ion chromatography (IC) and reversed-phase high performance liquid chromatography (RP-HPLC)) to detect, identify and quantify residues in human handmarks of explosives and energetic salts commonly used to manufacture Improvised Explosive Devices (IEDs) including dynamite, ammonium nitrate, single- and double-smokeless gunpowders and black powder...
December 1, 2016: Talanta
Arancha Cebrián, Teresa Gómez Del Pulgar, Maria Jesús Fernández-Aceñero, Aurea Borrero-Palacios, Laura Del Puerto-Nevado, Javier Martínez-Useros, Juan Pablo Marín-Arango, Cristina Caramés, Ricardo Vega-Bravo, María Rodríguez-Remírez, Felix Manzarbeitia, Jesús García-Foncillas
AIM: Polo-like kinase 1 (Plk1) plays a key role in mitotic cell division and DNA damage repair. It has been observed that either up-regulated or down-regulated Plk1 could induce mitotic defects that results in aneuploidy and tumorigenesis, probably depending on the context. Few previous reports have associated Plk1 expression with prognosis and response to radiotherapy in rectal carcinomas. The aim of this study is to investigate the prognostic impact of Plk1 expression and its role in predicting response to neoadjuvant cheomoradiotherapy in rectal cancer...
September 22, 2016: Pathology, Research and Practice
Momoko Horikoshi, Robin N Beaumont, Felix R Day, Nicole M Warrington, Marjolein N Kooijman, Juan Fernandez-Tajes, Bjarke Feenstra, Natalie R van Zuydam, Kyle J Gaulton, Niels Grarup, Jonathan P Bradfield, David P Strachan, Ruifang Li-Gao, Tarunveer S Ahluwalia, Eskil Kreiner, Rico Rueedi, Leo-Pekka Lyytikäinen, Diana L Cousminer, Ying Wu, Elisabeth Thiering, Carol A Wang, Christian T Have, Jouke-Jan Hottenga, Natalia Vilor-Tejedor, Peter K Joshi, Eileen Tai Hui Boh, Ioanna Ntalla, Niina Pitkänen, Anubha Mahajan, Elisabeth M van Leeuwen, Raimo Joro, Vasiliki Lagou, Michael Nodzenski, Louise A Diver, Krina T Zondervan, Mariona Bustamante, Pedro Marques-Vidal, Josep M Mercader, Amanda J Bennett, Nilufer Rahmioglu, Dale R Nyholt, Ronald C W Ma, Claudia H T Tam, Wing Hung Tam, Santhi K Ganesh, Frank J A van Rooij, Samuel E Jones, Po-Ru Loh, Katherine S Ruth, Marcus A Tuke, Jessica Tyrrell, Andrew R Wood, Hanieh Yaghootkar, Denise M Scholtens, Lavinia Paternoster, Inga Prokopenko, Peter Kovacs, Mustafa Atalay, Sara M Willems, Kalliope Panoutsopoulou, Xu Wang, Lisbeth Carstensen, Frank Geller, Katharina E Schraut, Mario Murcia, Catharina E M van Beijsterveldt, Gonneke Willemsen, Emil V R Appel, Cilius E Fonvig, Caecilie Trier, Carla M T Tiesler, Marie Standl, Zoltán Kutalik, Sílvia Bonàs-Guarch, David M Hougaard, Friman Sánchez, David Torrents, Johannes Waage, Mads V Hollegaard, Hugoline G de Haan, Frits R Rosendaal, Carolina Medina-Gomez, Susan M Ring, Gibran Hemani, George McMahon, Neil R Robertson, Christopher J Groves, Claudia Langenberg, Jian'an Luan, Robert A Scott, Jing Hua Zhao, Frank D Mentch, Scott M MacKenzie, Rebecca M Reynolds, William L Lowe, Anke Tönjes, Michael Stumvoll, Virpi Lindi, Timo A Lakka, Cornelia M van Duijn, Wieland Kiess, Antje Körner, Thorkild I A Sørensen, Harri Niinikoski, Katja Pahkala, Olli T Raitakari, Eleftheria Zeggini, George V Dedoussis, Yik-Ying Teo, Seang-Mei Saw, Mads Melbye, Harry Campbell, James F Wilson, Martine Vrijheid, Eco J C N de Geus, Dorret I Boomsma, Haja N Kadarmideen, Jens-Christian Holm, Torben Hansen, Sylvain Sebert, Andrew T Hattersley, Lawrence J Beilin, John P Newnham, Craig E Pennell, Joachim Heinrich, Linda S Adair, Judith B Borja, Karen L Mohlke, Johan G Eriksson, Elisabeth Widén, Mika Kähönen, Jorma S Viikari, Terho Lehtimäki, Peter Vollenweider, Klaus Bønnelykke, Hans Bisgaard, Dennis O Mook-Kanamori, Albert Hofman, Fernando Rivadeneira, André G Uitterlinden, Charlotta Pisinger, Oluf Pedersen, Christine Power, Elina Hyppönen, Nicholas J Wareham, Hakon Hakonarson, Eleanor Davies, Brian R Walker, Vincent W V Jaddoe, Marjo-Riitta Järvelin, Struan F A Grant, Allan A Vaag, Debbie A Lawlor, Timothy M Frayling, George Davey Smith, Andrew P Morris, Ken K Ong, Janine F Felix, Nicholas J Timpson, John R B Perry, David M Evans, Mark I McCarthy, Rachel M Freathy
Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease. These life-course associations have often been attributed to the impact of an adverse early life environment. Here, we performed a multi-ancestry genome-wide association study (GWAS) meta-analysis of BW in 153,781 individuals, identifying 60 loci where fetal genotype was associated with BW (P < 5 × 10(-8))...
September 28, 2016: Nature
Jesús Mateos, Isabel Carneiro, Fernando Corrales, Felix Elortza, Alberto Paradela, Manuel Sánchez Del Pino, Ibon Iloro, Miguel Marcilla, Maria Isabel Mora, Luz Valero, Sergio Ciordia, Verónica Fernández, Maria Antonia Fortuño, Isabel García-Sánchez, Rosario Martínez, Maria Angeles Muñoz, Clara Rodriguez, Nieves Doménech
: Analytical proteomics has experienced exponential progress in the last decade and can be expected to lead research studies on diagnostic and therapeutic biomarkers in the near future. Because the development of this type of analysis requires the use of a large number of human samples with a minimum of quality requirements, our objective was to identify appropriate indicators for quality control of plasma samples stored in biobanks for research in proteomics. To accomplish this, plasma samples from 100 healthy donors were obtained and processed according to the pre-analytical variables of: a) time delay for the first centrifugation of the original blood sample (4 or 24h) and b) number of freeze/thaw cycles (1, 2 or 3) of the processed plasma samples...
September 9, 2016: Journal of Proteomics
Israel Contador, Katie Almondes, Bernardino Fernández-Calvo, Elina Boycheva, Verónica Puertas-Martín, Julián Benito-León, Félix Bermejo-Pareja
OBJECTIVE: We aimed to provide the normative data stratified by age, sex and educational attainment for two semantic categories (animal and fruits) in older Spanish adults. METHOD: A representative sample of 2,744 non-demented older individuals with different socioeconomic background was selected from the Neurological Disorders in Central Spain (NEDICES), a population-based study. Normative data are presented in percentile ranks and divided into four age-tables with different midpoints, using the overlapping interval procedure...
September 6, 2016: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
Felix Schiele, Pelin Ayaz, Amaury Fernández-Montalván
No abstract text is available yet for this article.
December 1, 2016: Analytical Biochemistry
Mónica González, Emilio Macias-Escalada, Juan Cobo, Maria Pilar Fernández Mondragón, Gerardo Gómez-Moreno, Marian Martínez-Martínez, Felix de Carlos
BACKGROUND: Statins are considered the most effective drugs used in the treatment of dyslipidemias. Some of their adverse effects are related to muscle problems. Myalgias produced by statins appear more often during exercise. Mandibular advancement devices (MAD) force the propulsory and elevatory musculature of the mandible to exercise by making the jaw move forward. The aim of this study is to evaluate the incidence of muscular side effects (referred, spontaneous, or under palpation pain, myofascial pain, mandibular rigidity and fatigue, tension and sensitivity of the masticatory muscles) in a group of patients with a diagnosis of obstructive sleep apnea being treated with MAD...
August 25, 2016: Sleep & Breathing, Schlaf & Atmung
Vanesa Fernández-Majada, Patrick-Simon Welz, Maria A Ermolaeva, Michael Schell, Alexander Adam, Felix Dietlein, David Komander, Reinhard Büttner, Roman K Thomas, Björn Schumacher, Manolis Pasparakis
The tumour suppressor CYLD is a deubiquitinase previously shown to inhibit NF-κB, MAP kinase and Wnt signalling. However, the tumour suppressing mechanisms of CYLD remain poorly understood. Here we show that loss of CYLD catalytic activity causes impaired DNA damage-induced p53 stabilization and activation in epithelial cells and sensitizes mice to chemical carcinogen-induced intestinal and skin tumorigenesis. Mechanistically, CYLD interacts with and deubiquitinates p53 facilitating its stabilization in response to genotoxic stress...
2016: Nature Communications
Ana V Marin, Anaïs Jiménez-Reinoso, Alejandro C Briones, Miguel Muñoz-Ruiz, Cigdem Aydogmus, Luke J Pasick, Jorge Couso, Marina S Mazariegos, Angel F Alvarez-Prado, Alfonso Blázquez-Moreno, Funda E Cipe, Sule Haskologlu, Figen Dogu, Matías Morín, Miguel A Moreno-Pelayo, Félix García-Sánchez, Juana Gil-Herrera, Edgar Fernández-Malavé, Hugh T Reyburn, Almudena R Ramiro, Aydan Ikinciogullari, Maria J Recio, Jose R Regueiro, Beatriz Garcillán
No abstract text is available yet for this article.
August 20, 2016: Journal of Allergy and Clinical Immunology
Juan Menéndez, Isabel Álvarez, Iván Fernandez, Nuria A Menéndez-Arias, Félix Goyache
Estimating effective population size (N e ) using linkage disequilibrium (LD) information (N e( LD ) ) has the operational advantage of using a single sample. However, N e( LD ) estimates assume discrete generations and its performance are constrained by demographic issues. However, such concerns have received little empirical attention so far. The pedigree of the endangered Gochu Asturcelta pig breed includes individuals classified into discrete filial generations and individuals with generations overlap. Up to 780 individuals were typed with a set of 17 microsatellites...
July 2016: Ecology and Evolution
Alberto Soriano-Maldonado, Virginia A Aparicio, Francisco J Félix-Redondo, Daniel Fernández-Bergés
BACKGROUND: The aims of this study were 1) to examine potential sex-related differences in major cardiometabolic risk factors among severe/morbid obese (body mass index [BMI]≥35) individuals; 2) to assess whether severity of obesity is associated with more adverse cardiometabolic risk factors in women and men, and 3) to assess whether being physically active (≥500 metabolic equivalents [MET-minutes per week]) may play a role in the association between severity of obesity and the cardiometabolic risk profile...
November 15, 2016: International Journal of Cardiology
William S Knechtle, Sebastian D Perez, Mehul V Raval, Patrick S Sullivan, Yazan M Duwayri, Felix Fernandez, Joe Sharma, John F Sweeney
Quality-cost diagrams have been used previously to assess interventions and their cost-effectiveness. This study explores the use of risk-adjusted quality-cost diagrams to compare the value provided by surgeons by presenting cost and outcomes simultaneously. Colectomy cases from a single institution captured in the National Surgical Quality Improvement Program database were linked to hospital cost-accounting data to determine costs per encounter. Risk adjustment models were developed and observed average cost and complication rates per surgeon were compared to expected cost and complication rates using the diagrams...
August 16, 2016: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
María A Fernández-Seara, Zachary B Rodgers, Erin K Englund, Felix W Wehrli
Calibrated fMRI techniques estimate task-induced changes in the cerebral metabolic rate of oxygen (CMRO2) based on simultaneous measurements of cerebral blood flow (CBF) and blood-oxygen-level-dependent (BOLD) signal changes evoked by stimulation. To determine the calibration factor M (corresponding to the maximum possible BOLD signal increase), BOLD signal and CBF are measured in response to a gas breathing challenge (usually CO2 or O2). Here we describe an ASL dual-acquisition sequence that combines a background-suppressed 3D-GRASE readout with 2D multi-slice EPI...
August 5, 2016: NeuroImage
Markus J Barten, Uwe Schulz, Andres Beiras-Fernandez, Michael Berchtold-Herz, Udo Boeken, Jens Garbade, Stephan Hirt, Manfred Richter, Arjang Ruhpawar, Jan Dieter Schmitto, Felix Schönrath, Rene Schramm, Martin Schweiger, Markus Wilhelm, Andreas Zuckermann
There is currently no consensus regarding the dose or duration of rabbit antithymocyte globulin (rATG) induction in different types of heart transplant patients, or the timing and intensity of initial calcineurin inhibitor (CNI) therapy in rATG-treated individuals. Based on limited data and personal experience, the authors propose an approach to rATG dosing and initial CNI administration. Usually rATG is initiated immediately after exclusion of primary graft failure, although intraoperative initiation may be appropriate in specific cases...
June 2016: Transplantation Direct
A Vargas-Meza, M Chavez-Tostado, A O Cortes-Flores, D Urias-Valdez, M Delgado-Gomez, G Morgan-Villela, C Zuloaga-Fernandez Del Valle, J Jimenez-Tornero, R Zuloaga-Fernandez Del Valle, C Fuentes-Orozco, J García-Rentería, J Rendón-Félix, L Cuesta-Márquez, A Gonzalez-Ojeda
Weight gain is observed in breast cancer patients receiving chemotherapy and is a well-known complication. Several factors that contributing to weight gain have been identified. However, there is a lack of information about factors associated with weight changes following adjuvant chemotherapy. A retrospective cohort of 200 pre- and post-menopausal Mexican patients treated for breast cancer was made. Anthropometric variables were measured before/after treatment. Biomarkers, cellular differentiation and chemotherapy were similar between groups...
August 1, 2016: European Journal of Cancer Care
Rachel L Medbery, Theresa W Gillespie, Yuan Liu, Dana C Nickleach, Joseph Lipscomb, Manu S Sancheti, Allan Pickens, Seth D Force, Felix G Fernandez
BACKGROUND: Data regarding risk factors for readmissions after surgical resection for lung cancer are limited and largely focus on postoperative outcomes, including complications and hospital length of stay. The current study aims to identify preoperative risk factors for postoperative readmission in early stage lung cancer patients. METHODS: The National Cancer Data Base was queried for all early stage lung cancer patients with clinical stage T2N0M0 or less who underwent lobectomy in 2010 and 2011...
July 28, 2016: Annals of Thoracic Surgery
Trevor Williams, Brian C Gulack, Sunghee Kim, Felix G Fernandez, Mark K Ferguson
BACKGROUND: Although body mass index (BMI) has been used in risk stratification for lung resection, many models only take obesity into account. Recent studies have demonstrated that underweight patients also experience increased postoperative complications. We explored the relationship of extremes of BMI to outcomes after lung resection for non-small cell cancer. METHODS: Patients in the Society of Thoracic Surgeons General Thoracic Surgery Database (2009 to 2014) undergoing elective lung resection for cancer were evaluated...
July 28, 2016: Annals of Thoracic Surgery
Virginia A Aparicio, Alberto Soriano-Maldonado, Francisco Buitrago, Francisco J Félix-Redondo, Daniel Fernández-Bergés
No abstract text is available yet for this article.
October 2016: Revista Española de Cardiología
Irene Iriarte-Carretero, Miguel A Gonzalez, Jeff Armstrong, Felix Fernandez-Alonso, Fernando Bresme
We investigate using non-equilibrium molecular dynamics simulations the polarization of water induced by thermal gradients using the accurate TIP4P/2005 water model. The full dependence of the polarization covering a wide range of thermodynamic states, from near supercritical to ambient conditions, is reported. Our results show a strong dependence of the thermo-polarization field with the thermodynamic state. The field features a strong enhancement near the critical point, which can be rationalized in terms of the large increase and ultimately the divergence of the thermal expansion of the fluid at the critical temperature...
July 20, 2016: Physical Chemistry Chemical Physics: PCCP
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