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Felix Fernandez

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https://www.readbyqxmd.com/read/27911956/adenosine-stimulate-proliferation-and-migration-in-triple-negative-breast-cancer-cells
#1
Miriam Fernandez-Gallardo, Ricardo González-Ramírez, Alejandro Sandoval, Ricardo Felix, Eduardo Monjaraz
Emerging evidence suggests that the adenosine (Ado) receptors may play crucial roles in tumor progression. Here, we show that Ado increases proliferation and migration in a triple negative breast cancer model, the MDA-MB 231 cell line. The use of specific agonists and antagonists evidenced that these effects depend on the activation of the A2B receptor, which then triggers an intracellular response mediated by the adenylate cyclase/PKA/cAMP signaling pathway. Ado also increases the expression of NaV1.5 channels, a potential biomarker in breast cancer...
2016: PloS One
https://www.readbyqxmd.com/read/27908772/anaplasma-platys-in-dogs-from-uruguay
#2
Luis Carvalho, Maria Teresa Armua-Fernandez, Nicolás Sosa, María Laura Félix, José Manuel Venzal
Anaplasmataceae family members include vector-borne bacteria of veterinary importance that may also affect humans. Ehrlichia canis and Anaplasma platys are the main members of this family detected in dogs worldwide. In Uruguay there are not many published studies on tick-borne pathogens affecting dogs, the only haemoparasite molecularly confirmed in dogs, is the piroplasm Rangelia vitalii. The aim of the present work was to detect the presence of A. platys and E. canis in dogs and dogs-associated ticks of two localities in Northwestern Uruguay...
November 17, 2016: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/27851286/1651-intravascular-cooling-catheter-related-venous-thromboembolism-after-hypothermia-protocol
#3
Xuan Wang, Brian Moy, Felix Krainski, Victoria Forbes, William Duvall, Antonio Fernandez
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27847042/the-society-of-thoracic-surgeons-national-database-2016-annual-report
#4
Jeffrey P Jacobs, David M Shahian, Richard L Prager, Fred H Edwards, Donna McDonald, Jane M Han, Richard S D'Agostino, Marshall L Jacobs, Benjamin D Kozower, Vinay Badhwar, Vinod H Thourani, Henning A Gaissert, Felix G Fernandez, Cameron D Wright, Gaetano Paone, Joseph C Cleveland, J Matthew Brennan, Rachel S Dokholyan, Leo Brothers, Sreekanth Vemulapalli, Robert H Habib, Sean M O'Brien, Eric D Peterson, Frederick L Grover, G Alexander Patterson, Joseph E Bavaria
The art and science of outcomes analysis, quality improvement, and patient safety continue to evolve, and cardiothoracic surgery leads many of these advances. The Society of Thoracic Surgeons (STS) National Database is one of the principal reasons for this leadership role, as it provides a platform for the generation of knowledge in all of these domains. Understanding these topics is a professional responsibility of all cardiothoracic surgeons. Therefore, beginning in January 2016, The Annals of Thoracic Surgery began publishing a monthly series of scholarly articles on outcomes analysis, quality improvement, and patient safety...
December 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27823711/central-sleep-apnea-in-children-experience-at-a-single-center
#5
Orlane Felix, Alessandro Amaddeo, Jorge Olmo Arroyo, Michel Zerah, Stephanie Puget, Valerie Cormier-Daire, Genevieve Baujat, Graziella Pinto, Marta Fernandez-Bolanos, Brigitte Fauroux
OBJECTIVE: Central sleep apnea (CSA) syndromes are rare in children and data in children over one year of age are scarce. The aim of the study was to describe the sleep characteristics, underlying disorders, management, and outcome of children with CSA. PATIENTS/METHODS: A retrospective chart review of all children >1 year of age, diagnosed with CSA on a laboratory sleep study during a 20-month period, was performed. CSA was defined by a central apnea index (CAI) >5 events/h...
September 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27821895/health-care-utilization-of-mexican-patients-with-medically-unexplained-physical-symptoms
#6
Azucena Maribel Rodriguez González, José Manuel Ramírez Aranda, Homero de Los Santos Reséndiz, María Yolanda Lara Duarte, Santiago Oscar Pazaran Zanella, Jafet Felipe Méndez López, Issa Gil Alfaro, Félix Gilberto Islas Ruz, Gloria Navarrete Floriano, Edith Guillen Salomón, Obdulia Texon Fernández, Silvia Cruz Duarte, Juan Carlos Romo Salazar, Claudia Elsa Pérez Ruiz, Sara de Jesús López Salas, Lizbeth Benítez Amaya, Javier Nahum Zapata Gallardo
OBJECTIVE: To determine the prevalence of medically unexplained physical symptoms and the characteristics and use of health services in a group of patients with medically unexplained physical symptoms and a group of patients with other illnesses. METHODS: This was a cross-sectional, retrospective and multicenter study. We included 1,043 patients over 18 years of age from 30 primary care units of a government health institution, in 11 states of Mexico, attended by 39 family physicians...
September 30, 2016: Colombia Médica: CM
https://www.readbyqxmd.com/read/27815703/development-of-an-activity-disease-score-in-patients-with-uveitis-uvedai
#7
Esperanza Pato, Mª Auxiliadora Martin-Martinez, Adela Castelló, Rosalía Méndez-Fernandez, Santiago Muñoz-Fernández, Miguel Cordero-Coma, Lucia Martinez-Costa, Elia Valls, Miguel Reyes, Félix Francisco, Mar Esteban, Alex Fonollosa, Fernando Sanchez-Alonso, Cruz Fernández-Espartero, Teresa Diaz-Valle, José Miguel Carrasco, Emma Beltran-Catalán, Marisa Hernández-Garfella, María Victoria Hernández, Laura Pelegrin, Ricardo Blanco, David Diaz-Valle
To develop a disease activity index for patients with uveitis (UVEDAI) encompassing the relevant domains of disease activity considered important among experts in this field. The steps for designing UVEDAI were: (a) Defining the construct and establishing the domains through a formal judgment of experts, (b) A two-round Delphi study with a panel of 15 experts to determine the relevant items, (c) Selection of items: A logistic regression model was developed that set ocular inflammatory activity as the dependent variable...
November 4, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27809369/luminescent-thermochromism-of-2d-coordination-polymers-based-on-copper-i-halides-with-4-hydroxythiophenol
#8
Javier Troyano, Josefina Perles, Pilar Amo-Ochoa, Jose Ignacio Martínez, Maria Concepción Gimeno, Vanesa Fernández-Moreira, Félix Zamora, Salomé Delgado
Solvothermal reactions between copper(I) halides and 4-mercaptophenol give rise to the formation of three coordination polymers with general formula [Cu3 X(HT)2 ]n (X=Cl, 1; Br, 2; and I, 3). The structures of these coordination polymers have been determined by X-ray diffraction at both room- and low temperature (110 K), showing a general shortening in Cu-S, Cu-X and Cu-Cu bond lengths at low temperatures. 1 and 2 are isostructural, consisting of layers in which the halogen ligands act as μ3 -bridges joining two Cu1 and one Cu2 atoms whereas in 3 the iodine ligands is as μ4 -mode but the layers are quasi-isostructural with 1 or 2...
November 3, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27804302/unexpected-cation-dynamics-in-the-low-temperature-phase-of-methylammonium-lead-iodide-the-need-for-improved-models
#9
Kacper Drużbicki, Roberto Simone Pinna, Svemir Rudic, Marek Jura, Giuseppe Gorini, Felix Fernandez-Alonso
High-resolution inelastic neutron scattering and extensive first-principles calculations have been used to explore the low-temperature phase of the hybrid solar-cell material me-thylammonium lead iodide up to the well-known phase transition to the tetragonal phase at ca. 160 K. Contrary to original expectation, we find that the Pnma structure for this phase can only provide a qualitative description of the geometry and underlying motions of the organic cation. A substantial lowering of the local symmetry inside the perovskite cage leads to an improved atomis-tic model that can account for all available spectroscopic and thermodynamic data, both at low temperatures and in the vicinity of the aforementioned phase transition...
November 2, 2016: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27801525/complement-c3f-allotype-synthesized-by-liver-recipient-modifies-transplantation-outcome-independently-from-donor-hepatic-c3
#10
Diana María Valero-Hervás, Elena Sánchez-Zapardiel, María José Castro, Fernando Gallego-Bustos, Félix Cambra, Iago Justo, Rocío Laguna-Goya, Carlos Jiménez-Romero, Enrique Moreno, Francisco López-Medrano, Rafael San Juan, Mario Fernández-Ruiz, José María Aguado, Estela Paz-Artal
Complement component 3 (C3) presents both slow (C3S) and fast (C3F) variants, which can be locally-produced and activated by immune system cells. We studied C3 recipient variants in 483 liver transplant patients by RT-PCR-HRM to determine their effect on graft outcome during the first year post-transplantation. Allograft survival was significantly decreased in C3FF recipients (C3SS 95% vs. C3FS 91% vs. C3FF 83%; p=0.01) or C3F allele carriers (C3F-absence 95% vs. C3F-presence 90%, p=0.02). C3FF genotype or presence of C3F allele independently increased risk for allograft loss (OR: 2...
November 1, 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/27790648/complex-chromene-derivatives-through-a-silver-catalysed-cascade-reaction-of-simple-o-alkynylsalicylaldehydes-and-alkenes
#11
Tamara Arto, Patricia Fernández, Francisco J Fañanás, Félix Rodríguez
The silver-catalysed reaction of simple ortho-alkynylsalicylaldehydes and alkenes gives complex benzo[de]chromenyl ketones through an unusual cascade process where the starting ortho-alkynylsalicylaldehyde behaves as a bis-diene derivative that participates in two different formal [4+2]-cycloaddition reactions.
October 28, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27776958/trends-in-stroke-hospitalisation-rates-in-extremadura-between-2002-and-2014-changing-the-notion-of-stroke-as-a-disease-of-the-elderly
#12
J M Ramírez-Moreno, F J Felix-Redondo, D Fernández-Bergés, L Lozano-Mera
BACKGROUND: The incidence of stroke in Spain has been evaluated in several studies, whose results are highly variable and not comparable. No studies of stroke have analysed epidemiological changes in younger patients. METHOD: We conducted a retrospective observational study using the Spanish health system's Minimum Data Set and included all patients older than 19 hospitalised due to stroke (ICD-9-CM codes 434.01, 434.11, 434.91, 430, 431, 432.9, 436, and 435) between 2002 and 2013...
October 21, 2016: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/27772572/the-society-of-thoracic-surgeons-general-thoracic-surgery-database-2016-update-on%C3%A2-research
#13
Henning A Gaissert, Felix G Fernandez, Mark S Allen, William R Burfeind, Mark I Block, James M Donahue, John D Mitchell, Paul H Schipper, Mark W Onaitis, Andrzej S Kosinski, Jeffrey P Jacobs, David M Shahian, Benjamin D Kozower, Fred H Edwards, Emily A Conrad, G Alexander Patterson
The Society of Thoracic Surgeons General Thoracic Surgery Database has grown to more than 500,000 case records. Clinical research supported by the database is increasingly used to advance patient outcomes. This research review from the General Thoracic Surgery Database in 2014 and 2015 discusses 6 recent publications and an ongoing study on longitudinal outcomes in lung cancer surgery from The Society of Thoracic Surgeons Task Force for Linked Registries and Longitudinal Follow-up. A lack of database variables specific for certain uncommon procedures limits the ability to study these operations; inclusion of clinical descriptors for selected infrequent but clinically important thoracic disorders is suggested...
November 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27769399/progressing-the-analysis-of-improvised-explosive-devices-comparative-study-for-trace-detection-of-explosive-residues-in-handprints-by-raman-spectroscopy-and-liquid-chromatography
#14
Félix Zapata, Mª Ángeles Fernández de la Ossa, Elizabeth Gilchrist, Leon Barron, Carmen García-Ruiz
Concerning the dreadful global threat of terrorist attacks, the detection of explosive residues in biological traces and marks is a current need in both forensics and homeland security. This study examines the potential of Raman microscopy in comparison to liquid chromatography (ion chromatography (IC) and reversed-phase high performance liquid chromatography (RP-HPLC)) to detect, identify and quantify residues in human handmarks of explosives and energetic salts commonly used to manufacture Improvised Explosive Devices (IEDs) including dynamite, ammonium nitrate, single- and double-smokeless gunpowders and black powder...
December 1, 2016: Talanta
https://www.readbyqxmd.com/read/27712975/decreased-plk1-expression-denotes-therapy-resistance-and-unfavourable-disease-free-survival-in-rectal-cancer-patients-receiving-neoadjuvant-chemoradiotherapy
#15
Arancha Cebrián, Teresa Gómez Del Pulgar, Maria Jesús Fernández-Aceñero, Aurea Borrero-Palacios, Laura Del Puerto-Nevado, Javier Martínez-Useros, Juan Pablo Marín-Arango, Cristina Caramés, Ricardo Vega-Bravo, María Rodríguez-Remírez, Felix Manzarbeitia, Jesús García-Foncillas
AIM: Polo-like kinase 1 (Plk1) plays a key role in mitotic cell division and DNA damage repair. It has been observed that either up-regulated or down-regulated Plk1 could induce mitotic defects that results in aneuploidy and tumorigenesis, probably depending on the context. Few previous reports have associated Plk1 expression with prognosis and response to radiotherapy in rectal carcinomas. The aim of this study is to investigate the prognostic impact of Plk1 expression and its role in predicting response to neoadjuvant cheomoradiotherapy in rectal cancer...
September 22, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27680694/genome-wide-associations-for-birth-weight-and-correlations-with-adult-disease
#16
Momoko Horikoshi, Robin N Beaumont, Felix R Day, Nicole M Warrington, Marjolein N Kooijman, Juan Fernandez-Tajes, Bjarke Feenstra, Natalie R van Zuydam, Kyle J Gaulton, Niels Grarup, Jonathan P Bradfield, David P Strachan, Ruifang Li-Gao, Tarunveer S Ahluwalia, Eskil Kreiner, Rico Rueedi, Leo-Pekka Lyytikäinen, Diana L Cousminer, Ying Wu, Elisabeth Thiering, Carol A Wang, Christian T Have, Jouke-Jan Hottenga, Natalia Vilor-Tejedor, Peter K Joshi, Eileen Tai Hui Boh, Ioanna Ntalla, Niina Pitkänen, Anubha Mahajan, Elisabeth M van Leeuwen, Raimo Joro, Vasiliki Lagou, Michael Nodzenski, Louise A Diver, Krina T Zondervan, Mariona Bustamante, Pedro Marques-Vidal, Josep M Mercader, Amanda J Bennett, Nilufer Rahmioglu, Dale R Nyholt, Ronald C W Ma, Claudia H T Tam, Wing Hung Tam, Santhi K Ganesh, Frank J A van Rooij, Samuel E Jones, Po-Ru Loh, Katherine S Ruth, Marcus A Tuke, Jessica Tyrrell, Andrew R Wood, Hanieh Yaghootkar, Denise M Scholtens, Lavinia Paternoster, Inga Prokopenko, Peter Kovacs, Mustafa Atalay, Sara M Willems, Kalliope Panoutsopoulou, Xu Wang, Lisbeth Carstensen, Frank Geller, Katharina E Schraut, Mario Murcia, Catharina E M van Beijsterveldt, Gonneke Willemsen, Emil V R Appel, Cilius E Fonvig, Caecilie Trier, Carla M T Tiesler, Marie Standl, Zoltán Kutalik, Sílvia Bonàs-Guarch, David M Hougaard, Friman Sánchez, David Torrents, Johannes Waage, Mads V Hollegaard, Hugoline G de Haan, Frits R Rosendaal, Carolina Medina-Gomez, Susan M Ring, Gibran Hemani, George McMahon, Neil R Robertson, Christopher J Groves, Claudia Langenberg, Jian'an Luan, Robert A Scott, Jing Hua Zhao, Frank D Mentch, Scott M MacKenzie, Rebecca M Reynolds, William L Lowe, Anke Tönjes, Michael Stumvoll, Virpi Lindi, Timo A Lakka, Cornelia M van Duijn, Wieland Kiess, Antje Körner, Thorkild I A Sørensen, Harri Niinikoski, Katja Pahkala, Olli T Raitakari, Eleftheria Zeggini, George V Dedoussis, Yik-Ying Teo, Seang-Mei Saw, Mads Melbye, Harry Campbell, James F Wilson, Martine Vrijheid, Eco J C N de Geus, Dorret I Boomsma, Haja N Kadarmideen, Jens-Christian Holm, Torben Hansen, Sylvain Sebert, Andrew T Hattersley, Lawrence J Beilin, John P Newnham, Craig E Pennell, Joachim Heinrich, Linda S Adair, Judith B Borja, Karen L Mohlke, Johan G Eriksson, Elisabeth Widén, Mika Kähönen, Jorma S Viikari, Terho Lehtimäki, Peter Vollenweider, Klaus Bønnelykke, Hans Bisgaard, Dennis O Mook-Kanamori, Albert Hofman, Fernando Rivadeneira, André G Uitterlinden, Charlotta Pisinger, Oluf Pedersen, Christine Power, Elina Hyppönen, Nicholas J Wareham, Hakon Hakonarson, Eleanor Davies, Brian R Walker, Vincent W V Jaddoe, Marjo-Riitta Järvelin, Struan F A Grant, Allan A Vaag, Debbie A Lawlor, Timothy M Frayling, George Davey Smith, Andrew P Morris, Ken K Ong, Janine F Felix, Nicholas J Timpson, John R B Perry, David M Evans, Mark I McCarthy, Rachel M Freathy
Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease. These life-course associations have often been attributed to the impact of an adverse early life environment. Here, we performed a multi-ancestry genome-wide association study (GWAS) meta-analysis of BW in 153,781 individuals, identifying 60 loci where fetal genotype was associated with BW (P < 5 × 10(-8))...
September 28, 2016: Nature
https://www.readbyqxmd.com/read/27620695/multicentric-study-of-the-effect-of-pre-analytical-variables-in-the-quality-of-plasma-samples-stored-in-biobanks-using-different-complementary-proteomic-methods
#17
Jesús Mateos, Isabel Carneiro, Fernando Corrales, Felix Elortza, Alberto Paradela, Manuel Sánchez Del Pino, Ibon Iloro, Miguel Marcilla, Maria Isabel Mora, Luz Valero, Sergio Ciordia, Verónica Fernández, Maria Antonia Fortuño, Isabel García-Sánchez, Rosario Martínez, Maria Angeles Muñoz, Clara Rodriguez, Nieves Doménech
: Analytical proteomics has experienced exponential progress in the last decade and can be expected to lead research studies on diagnostic and therapeutic biomarkers in the near future. Because the development of this type of analysis requires the use of a large number of human samples with a minimum of quality requirements, our objective was to identify appropriate indicators for quality control of plasma samples stored in biobanks for research in proteomics. To accomplish this, plasma samples from 100 healthy donors were obtained and processed according to the pre-analytical variables of: a) time delay for the first centrifugation of the original blood sample (4 or 24h) and b) number of freeze/thaw cycles (1, 2 or 3) of the processed plasma samples...
September 9, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/27600449/semantic-verbal-fluency-normative-data-in-older-spanish-adults-from-nedices-population-based-cohort
#18
Israel Contador, Katie Almondes, Bernardino Fernández-Calvo, Elina Boycheva, Verónica Puertas-Martín, Julián Benito-León, Félix Bermejo-Pareja
OBJECTIVE: We aimed to provide the normative data stratified by age, sex and educational attainment for two semantic categories (animal and fruits) in older Spanish adults. METHOD: A representative sample of 2,744 non-demented older individuals with different socioeconomic background was selected from the Neurological Disorders in Central Spain (NEDICES), a population-based study. Normative data are presented in percentile ranks and divided into four age-tables with different midpoints, using the overlapping interval procedure...
September 6, 2016: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/27579818/corrigendum-to-a-universal-homogenous-assay-for-high-throughput-determination-of-binding-kinetics-anal-biochem-468-2015-42-49
#19
Felix Schiele, Pelin Ayaz, Amaury Fernández-Montalván
No abstract text is available yet for this article.
December 1, 2016: Analytical Biochemistry
https://www.readbyqxmd.com/read/27562773/can-treatment-with-statins-have-a-negative-influence-on-the-tolerance-of-mandibular-advancement-devices
#20
Mónica González, Emilio Macias-Escalada, Juan Cobo, Maria Pilar Fernández Mondragón, Gerardo Gómez-Moreno, Marian Martínez-Martínez, Felix de Carlos
BACKGROUND: Statins are considered the most effective drugs used in the treatment of dyslipidemias. Some of their adverse effects are related to muscle problems. Myalgias produced by statins appear more often during exercise. Mandibular advancement devices (MAD) force the propulsory and elevatory musculature of the mandible to exercise by making the jaw move forward. The aim of this study is to evaluate the incidence of muscular side effects (referred, spontaneous, or under palpation pain, myofascial pain, mandibular rigidity and fatigue, tension and sensitivity of the masticatory muscles) in a group of patients with a diagnosis of obstructive sleep apnea being treated with MAD...
August 25, 2016: Sleep & Breathing, Schlaf & Atmung
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