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Ed Chen

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https://www.readbyqxmd.com/read/29325484/risk-of-erectile-dysfunction-after-traumatic-brain-injury-a-nationwide-population-based-cohort-study-in-taiwan
#1
Yun-Ju Yang, Wu-Chien Chien, Chi-Hsiang Chung, Kun-Ting Hong, Yi-Lin Yu, Dueng-Yuan Hueng, Yuan-Hao Chen, Hsin-I Ma, Hsin-An Chang, Yu-Chen Kao, Hui-Wen Yeh, Nian-Sheng Tzeng
INTRODUCTION: In our study, we aimed to investigate the association between a traumatic brain injury (TBI) and subsequent erectile dysfunction (ED). This is a population-based study using the claims dataset from The National Health Insurance Research Database. METHODS: We included 72,642 patients with TBI aged over 20 years, retrospectively, selected from the longitudinal health insurance database during 2000-2010, according to the ICD-9-CM. The control group consisted of 217,872 patients without TBI that were randomly chosen from the database at a ratio of 1:3, with age- and index year matched...
January 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29325336/-dose-response-relationship-of-ropivacaine-for-epidural-block-in-early-herpes-zoster-guided-by-ct
#2
K Y Xie, J B Ma, Q Xu, B Huang, M Yao, H D Ni, J J Deng, G D Chen
Objective: To determine the dose-response relationship of ropivacaine for epidural block in early herpes zoster by CT guided. Methods: From January 2015 to February 2017, according to the principle of completely random digital table, 80 patients with early herpes zoster who were prepared for epidural block were divided into 4 groups(each group 20 patients): in group A the concentration of ropivacaine was 0.08%, in group B was 0.10%, in group C was 0.12% and in group D was 0.14%.Under CT guidance, epidural puncture was performed in the relevant section, mixing liquid 5...
December 26, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29319007/calpain-inhibition-improves-erectile-function-in-diabetic-mice-via-upregulating-endothelial-nitric-oxide-synthase-expression-and-reducing-apoptosis
#3
Hao Li, Li-Ping Chen, Tao Wang, Shao-Gang Wang, Ji-Hong Liu
Calpain activation contributes to hyperglycemia-induced endothelial dysfunction and apoptosis. This study was designed to investigate the role of calpain inhibition in improving diabetic erectile dysfunction (ED) in mice. Thirty-eight-week-old male C57BL/6J mice were divided into three groups: (1) nondiabetic control group, (2) diabetic mice + vehicle group, and (3) diabetic mice + MDL28170 (an inhibitor of calpain) group. Type 1 diabetes was induced by intraperitoneal injection of streptozotocin at 60 mg kg-1 body weight for 5 consecutive days...
January 9, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29279188/clinical-correlates-of-negative-health-events-in-a-research-sample-with-epilepsy
#4
Neha Kumar, Kari Colon-Zimmermann, Edna Fuentes-Casiano, Hongyan Liu, Curtis Tatsuoka, Kristin A Cassidy, Mustafa Kahriman, Peijun Chen, Martha Sajatovic
AIMS: In spite of advances in care, people with epilepsy experience negative health events (NHEs), such as seizures, emergency department (ED) visits, and hospitalizations. Being able to identify characteristics that are associated with NHE risk can help inform care approaches that reduce complications and burden. This analysis using baseline data from a larger randomized epilepsy self-management clinical trial assessed the relationship between demographic and clinical variables vs. seizure-related complications among people with epilepsy...
December 23, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29275048/changes-in-male-rat-sexual-behavior-and-brain-activity-revealed-by-functional-magnetic-resonance-imaging-in-response-to-chronic-mild-stress
#5
Guotao Chen, Baibing Yang, Jianhuai Chen, Leilei Zhu, Hesong Jiang, Wen Yu, Fengchao Zang, Yun Chen, Yutian Dai
BACKGROUND: Non-organic erectile dysfunction (noED) at functional imaging has been related to abnormal brain activity and requires animal models for further research on the associated molecular mechanisms. AIM: To develop a noED animal model based on chronic mild stress and investigate brain activity changes. METHODS: We used 6 weeks of chronic mild stress to induce depression. The sucrose consumption test was used to assess the hedonic state...
December 20, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29273747/residues-his172-and-lys238-are-essential-for-the-catalytic-activity-of-the-maleylacetate-reductase-from-sphingobium-chlorophenolicum-strain-l-1
#6
Lifeng Chen, Ed S Krol, Meena K Sakharkar, Haseeb A Khan, Abdullah S Alhomida, Jian Yang
Maleylacetate reductase (PcpE), the last enzyme in the pentachlorophenol biodegradation pathway in Sphingobium chlorophenolicum L-1, catalyzes two consecutive reductive reactions, reductive dehalogenation of 2-chloromaleylacetate (2-CMA) to maleylacetate (MA) and subsequent reduction of MA to 3-oxoadipate (3-OXO). In each reaction, one molecule of NADH is consumed. To better understand its catalytic function, we undertook a structural model-based site-directed mutagenesis and steady-state kinetics study of PcpE...
December 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29216942/-comparison-of-national-early-warning-score-rapid-emergency-medicine-score-and-acute-physiology-and-chronic-health-evaluation-ii-score-for-predicting-outcome-among-emergency-severe-patients
#7
Li Chen, Lipu Deng, Hongmei Zhao, Xiaoying Huang, Xianghua He, Xiangmin Li, Ben Liu, Yongxiang Xie
OBJECTIVE: To analyze the comparation of national early warning score (NEWS), rapid emergency medicine score (REMS) and acute physiology and chronic health evaluation II (APACHE II) score in predicting prognosis of critically ill patients in emergency department (ED). METHODS: A retrospective study was conducted. Critically ill patients, aged > 16 years, hospitalized > 24 hours, and admitted to the ED of Nanhua Hospital Affiliated to South China University from January 2016 to June 2017 were enrolled...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29187226/development-and-pilot-testing-of-an-informed-consent-video-for-patients-with-limb-trauma-prior-to-debridement-surgery-using-a-modified-delphi-technique
#8
Yen-Ko Lin, Chao-Wen Chen, Wei-Che Lee, Tsung-Ying Lin, Liang-Chi Kuo, Chia-Ju Lin, Leiyu Shi, Yin-Chun Tien, Yuan-Chia Cheng
BACKGROUND: Ensuring adequate informed consent for surgery in a trauma setting is challenging. We developed and pilot tested an educational video containing information regarding the informed consent process for surgery in trauma patients and a knowledge measure instrument and evaluated whether the audiovisual presentation improved the patients' knowledge regarding their procedure and aftercare and their satisfaction with the informed consent process. METHODS: A modified Delphi technique in which a panel of experts participated in successive rounds of shared scoring of items to forecast outcomes was applied to reach a consensus among the experts...
November 29, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/29181732/reporting-characteristics-of-case-reports-of-acupuncture-therapy-with-care-guidelines
#9
Guang-Hui An, Xiao-Ting Tang, Yao-Long Chen, Yi Zhao
OBJECTIVE: To investigate the reporting characteristics of case reports of acupuncture therapy with CAse Report (CARE) guidelines, and to explore the applicability of the guidelines for these case reports. METHODS: Case reports published from January 1, 2011 to December 31, 2013, were identified by searching PubMed and the China Biomedicine Database by using MeSH terms. Screening and data extraction of case reports were conducted by two independent researchers. Assessments based on CARE guidelines and data analysis were conducted by using Excel 2003 and RevMan 5...
November 28, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29179485/cost-effectiveness-analysis-of-fecal-microbiota-transplantation-for-inflammatory-bowel-disease
#10
Ting Zhang, Jie Xiang, Bota Cui, Zhi He, Pan Li, Hai Chen, Lijuan Xu, Guozhong Ji, Yongzhan Nie, Kaichun Wu, Daiming Fan, Guangming Huang, Jianling Bai, Faming Zhang
There is a lack of health economics evidence on the use of fecal microbiota transplantation (FMT) for inflammatory bowel disease (IBD). This study aims to evaluate the cost-effectiveness before (with conventional therapy) and after introducing FMT for treating IBD. 104 patients with IBD received FMT were recruited. Health status was evaluated by European dimension health table (ED-5Q). Incremental cost-effectiveness ratio (ICER) and net monetary benefit (NB) were calculated by different age groups, genders, smoking status, and disease subtypes...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29174837/accuracy-and-discomfort-of-different-types-of%C3%A2-intranasal-specimen-collection-methods-for%C3%A2-molecular-influenza-testing-in-emergency%C3%A2-department-patients
#11
Bradley W Frazee, Amparo Rodríguez-Hoces de la Guardia, Harrison Alter, Carol G Chen, Eugenia L Fuentes, Alison K Holzer, Macarena Lolas, Debkishore Mitra, Jaspreet Vohra, Cornelia L Dekker
STUDY OBJECTIVE: While development is under way of accurate, point-of-care molecular tests for influenza infection, the optimal specimen type for molecular tests remains unclear. Compared with standard nasopharyngeal swab specimens, less invasive nasal swab and midturbinate swab specimens may cause less patient discomfort and be more suitable for routine emergency department (ED) testing, although possibly at the expense of diagnostic accuracy. We compare both the accuracy of a polymerase chain reaction molecular influenza test and discomfort between these 3 intranasal specimen types...
November 23, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29150635/one-pot-synthesis-of-trifunctional-chitosan-edta-%C3%AE-cyclodextrin-polymer-for-simultaneous-removal-of-metals-and-organic-micropollutants
#12
Feiping Zhao, Eveliina Repo, Dulin Yin, Li Chen, Simo Kalliola, Juntao Tang, Evgenia Iakovleva, Kam Chiu Tam, Mika Sillanpää
The global contamination of water resources with inorganic and organic micropollutants, such as metals and pharmaceuticals, poses a critical threat to the environment and human health. Herein, we report on a bio-derived chitosan-EDTA-β-cyclodextrin (CS-ED-CD) trifunctional adsorbent fabricated via a facile and green one-pot synthesis method using EDTA as a cross-linker, for the adsorption of toxic metals and organic micropollutants from wastewater. In this system, chitosan chain is considered as the backbone, and the immobilized cyclodextrin cavities capture the organic compounds via host-guest inclusion complexation, while EDTA-groups complex metals...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137640/direct-reprogramming-of-mouse-fibroblasts-into-neural-cells-via-porphyra-yezoensis-polysaccharide-based-high-efficient-gene-co-delivery
#13
Qingtong Yu, Jingjing Chen, Wenwen Deng, Xia Cao, Yan Wang, Jie Zhou, Wenqian Xu, Pan Du, Qiang Wang, Jiangnan Yu, Ximing Xu
BACKGROUND: The cell source for transplantation therapy is always a prerequisite question to be solved in clinical applications. Neural cells are considered non-regenerable, which highly restrict their application in the treatment for nerve injury. Therefore, neural trans-differentiation based on gene transfection provides a new solution to this issue. Compared to viral strategy, non-viral gene delivery systems are considered as a more promising way to achieve this aim. This study centers on a novel application of Porphyra yezoensis polysaccharide as a non-viral gene carrier for the neural trans-differentiation of mouse fibroblasts...
November 14, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29128648/a-hypertension-emergency-department-intervention-aimed-at-decreasing-disparities-design-of-a-randomized-clinical-trial
#14
Heather M Prendergast, Marina Del Rios, Renee Petzel-Gimbar, Daniel Garside, Sara Heinert, Sandra Escobar-Schulz, Pavitra Kotini-Shah, Michael Brown, Jinsong Chen, Joseph Colla, Marian Fitzgibbon, Ramon A Durazo-Arvizu, Martha Daviglus
Effective interventions to identify and treat uncontrolled hypertension (HTN), particularly in underrepresented populations that use the emergency department (ED) for primary care, are critically needed. Uncontrolled HTN contributes significantly to cardiovascular morbidity and mortality and is more frequently encountered among patients presenting to the ED as compared to the primary care setting. EDs serve as the point of entry into the health care system for high-risk patient populations, including minority and low-income patients...
November 8, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29123014/positron-emission-tomography-using-a-grpr-antagonist-68ga-rm26-in-healthy-volunteers-and-prostate-cancer-patients
#15
Jingjing Zhang, Gang Niu, Xingrong Fan, Lixin Lang, Guozhu Hou, Libo Chen, Huanwen Wu, Zhaohui Zhu, Fang Li, Xiaoyuan Chen
This study was designed to study the safety, biodistribution, radiation dosimetry of a gastrin-releasing peptide receptor (GRPR) antagonist positron emission tomography (PET) tracer 68Ga-RM26, to assess its clinical diagnostic value in prostate cancer patients, and to perform a direct comparison between GRPR antagonist 68Ga-RM26 and agonist 68Ga-BBN. Methods: Five healthy volunteers were enrolled to validate the safety of 68Ga-RM26 and calculate dosimetry. A total of 28 patients with prostate cancer (17 newly diagnosed and 11 post therapy) were recruited with written informed consent...
November 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29117900/gestalt-for-shock-and-mortality-in-the-emergency-department-a-prospective-study
#16
Yan-Ling Li, Jun-Rong Mo, Nga-Man Cheng, Stewart S W Chan, Pei-Yi Lin, Xiao-Hui Chen, Colin A Graham, Timothy H Rainer
OBJECTIVE: The diagnosis of shock in patients presenting to the emergency department (ED) is often challenging. We aimed to compare the accuracy of experienced emergency physician gestalt against Li's pragmatic shock (LiPS) tool for predicting the likelihood of shock in the emergency department, using 30-day mortality as an objective standard. METHOD: In a prospective observational study conducted in an urban, academic ED in Hong Kong, adult patients aged 18years or older admitted to the resuscitation room or high dependency unit were recruited...
November 3, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29116014/quantitative-assessment-of-radiation-dose-and-fractionation-effects-on-normal-tissue-by-utilizing-a-novel-lung-fibrosis-index-model
#17
Cheng Zhou, Bleddyn Jones, Mahmoud Moustafa, Christian Schwager, Julia Bauer, Bing Yang, Liji Cao, Min Jia, Andrea Mairani, Ming Chen, Longhua Chen, Juergen Debus, Amir Abdollahi
BACKGROUND: Normal lung tissue tolerance constitutes a limiting factor in delivering the required dose of radiotherapy to cure thoracic and chest wall malignancies. Radiation-induced lung fibrosis (RILF) is considered a critical determinant for late normal tissue complications. While RILF mouse models are frequently approached e.g., as a single high dose thoracic irradiation to investigate lung fibrosis and candidate modulators, a systematic radiobiological characterization of RILF mouse model is urgently needed to compare relative biological effectiveness (RBE) of particle irradiation with protons, helium-, carbon and oxygen ions now available at HIT...
November 7, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29100592/peri-operative-emergency-department-utilization-in-inpatient-and-outpatient-medicare-laparoscopic-cholecystectomy
#18
Susan M Nedza, Donald E Fry, Michael Pine, Agnes M Reband, Pan Chen, Gregory Pine
BACKGROUND: Preoperative emergency department (ED) visits may reflect the patient's biliary disease, or may signal unstable comorbid conditions that have relevance following inpatient laparoscopic cholecystectomy (ILC) and outpatient laparoscopic cholecystectomy (OLC) in Medicare patients. METHODS: We used the Medicare inpatient and outpatient Limited Datasets to identify elective laparoscopic cholecystectomy patients from 2011 to 2014. ED visits for 30-days before the surgical event were identified and correlated with the probability of patients returning to the ED in the 30-days following the procedure...
October 24, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29095286/clinical-predictors-of-outcomes-in-patients-undergoing-emergency-air-medical-transport-from-kinmen-to-taiwan
#19
Julia Chia-Yu Chang, Hsien-Hao Huang, Shu-Hua Chang, Yin-Ru Chen, Ju-Shin Fan, Yen-Chia Chen, David Hung-Tsang Yen
Emergency air medical transport (EAMT) is indispensable for acutely or critically ill patients in remote areas. We determined patient-level and transport-specific factors associated with all-cause mortality after EAMT.We conducted a population-based, retrospective cohort study using a prospective registry consisting of clinical/medical records. Study inclusion criteria consisted of all adults undergoing EAMT from Kinmen hospital to the ED of Taipei Veterans General Hospital (TVGH) between January 1, 2006 and December 31, 2012...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29095274/comparison-of-the-effects-of-extracorporeal-shock-wave-therapy-and-a-vacuum-erectile-device-on-penile-erectile-dysfunction-a-randomized-clinical-trial
#20
RANDOMIZED CONTROLLED TRIAL
Tao Qi, Lei Ye, Bo Wang, Bin Zhang, Jun Chen
BACKGROUND: This randomized clinical trial (October 2012-December 2013) compared extracorporeal shock wave therapy (ESWT) and a vacuum erectile device (VED) for management of erectile dysfunction (ED). METHODS: Consecutive Chinese patients (20-55 years) with ED, abnormal nocturnal penile tumescence and rigidity (NPTR), and international index of erectile function-5 items (IIEF-5) score <22 were randomized to receive ESWT or VED (twice weekly, 4 weeks). Primary outcomes were treatment efficacy and success rate 4 weeks after completion of therapy...
November 2017: Medicine (Baltimore)
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