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Ed Chen

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https://www.readbyqxmd.com/read/28915258/rapid-emergency-medicine-score-a-novel-prognostic-tool-for-predicting-the-outcomes-of-adult-patients-with-hepatic-portal-venous-gas-in-the-emergency-department
#1
Chen-June Seak, David Hung-Tsang Yen, Chip-Jin Ng, Yon-Cheong Wong, Kuang-Hung Hsu, Joanna Chen-Yeen Seak, Hsien-Yi Chen, Chen-Ken Seak
OBJECTIVE: This study aims to evaluate the performance of Rapid Emergency Medicine Score (REMS), Rapid Acute Physiology Score (RAPS), and Modified Early Warning Score (MEWS) in ascertaining the severity of illness and predicting the mortality of adult hepatic portal venous gas (HPVG) patients presenting to the emergency department (ED). This will assist emergency physicians (EPs) in risk stratification. METHODS: Data for 66 adult HPVG patients who visited the EDs of 2 research hospitals between October 1999 and April 2016 were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28910952/-establishment-of-cut-off-value-of-serum-pro-gastrin-releasing-peptide-for-diagnosis-of-small-cell-lung-cancer-and-evaluation-on-the-clinical-diagnosis-efficiency
#2
D Shen, B B Han, F Chen, B J Wei, C J Cui, G J Wang, W Cui
Objective: To determine critical reference value (cut-off value) of serum pro-gastrin-releasing peptide (ProGRP) and neuron specific enolase(NSE) in the diagnosis of small cell lung cancer(SCLC). To evaluate the clinical significance of serum levels of ProGRP and NSE in diagnosis and differential diagnosis in SCLC. Methods: Three hundred and fifty-two SCLC patients, 163 non small cell lung cancer(NSCLC)patients , 193 benign pulmonary disease patients and 140 healthy people visiting in National Cancer Hospital were analyzed retrospectively from January 2014 to July 2017...
September 12, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28906442/the-role-of-ion-exchange-membranes-in-membrane-capacitive-deionisation
#3
REVIEW
Armineh Hassanvand, Kajia Wei, Sahar Talebi, George Q Chen, Sandra E Kentish
Ion-exchange membranes (IEMs) are unique in combining the electrochemical properties of ion exchange resins and the permeability of a membrane. They are being used widely to treat industrial effluents, and in seawater and brackish water desalination. Membrane Capacitive Deionisation (MCDI) is an emerging, energy efficient technology for brackish water desalination in which these ion-exchange membranes act as selective gates allowing the transport of counter-ions toward carbon electrodes. This article provides a summary of recent developments in the preparation, characterization, and performance of ion exchange membranes in the MCDI field...
September 14, 2017: Membranes
https://www.readbyqxmd.com/read/28901433/expression-of-long-non%C3%A2-coding-rnas-in-human-bone-marrow-mesenchymal-stem-cells-co%C3%A2-cultured-with-human-amnion%C3%A2-derived-mesenchymal-stem-cells
#4
Jingjing Wang, Jing Miao, Xin Meng, Ning Chen, Yuli Wang
Long non‑coding RNAs (lncRNAs) serve a critical role in various biological processes including cell growth, transcriptional regulation and differentiation. Previous studies have demonstrated that human amnion‑derived mesenchymal stem cells (HAMSCs) possess the potential to promote proliferation and osteogenic differentiation of human bone marrow mesenchymal stem cells (HBMSCs). However, little is known about the roles of lncRNAs in these mechanisms. The present study investigated the expression of lncRNAs in HBMSCs co‑cultured with HAMSCs to study their involvement in the mechanism of osteogenic differentiation...
September 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28855426/neural-differentiation-of-fibroblasts-induced-by-intracellular-co-delivery-of-ascl1-brn2-and-foxa1-via-a-non-viral-vector-of-cationic-polysaccharide
#5
Qingtong Yu, Jingjing Chen, Wenwen Deng, Xia Cao, Michael Adu-Frimpong, Jiangnan Yu, Xi-Ming Xu
Direct reprogramming of other somatic cells into neurons is an alternative strategy for the recovery of injured nervous system. In this work we developed a new non-viral gene carrier based on Porphyra yezoensis polysaccharide (PYP). After modification with ethylenediamine, the cationized Porphyra yezoensis polysaccharide (Ed-PYP) was combined with plasmids encoding Ascl1, Brn2 and FoxA1 to form spherical nanoscale particles (Ed-PYP-pABF nanoparticles). Cytotoxicity assay proved that Ed-PYP-pABF nanoparticles had a safer property than Lipofectamine2000 and polyetherimide (PEI)...
August 31, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28837017/sustainable-benefits-of-a-community-hospital-based-paediatric-asthma-clinic
#6
Brian A Kuzik, Chee P Chen, Miriam J Hansen, Paula L Montgomery
In 2011, we reported that our paediatric asthma clinic (PAC) appeared to significantly reduce the burden of paediatric asthma in our community. Supported by these results, the PAC underwent a gradual threefold expansion while maintaining the same model of care. We now report on the outcome of that expansion and demonstrate that our PAC continues to significantly reduce the burden of paediatric asthma in our community. As previously, newly enrolled PAC patients continue to show a 12-month reduction in asthma-related emergency department (ED) visits and admissions exceeding 60% and 80%, respectively...
2017: Healthcare Quarterly
https://www.readbyqxmd.com/read/28827246/usage-of-ambulance-transport-and-influencing-factors-in-acute-coronary-syndrome-a-cross-sectional-study-at-a-tertiary-centre-in-china
#7
Jingjing Ma, Jiali Wang, Wen Zheng, Jiaqi Zheng, Hao Wang, Guangmei Wang, He Zhang, Feng Xu, Yuguo Chen
OBJECTIVES: The aim of this study was to explore the choice of transportation mode to hospital in patients with acute coronary syndrome (ACS) and to determine the factors influencing the use of ambulance. DESIGN, SETTING AND PARTICIPANTS: This cross-sectional study was conducted in a tertiary and teaching hospital in China. The study was carried out between 24 August 2015 and 24 July 2016. A total of 828 patients with ACS presented at the emergency department (ED) were included...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28826639/fewer-immigrants-have-preventable-emergency-department-visits-in-the-united-states
#8
Yang Wang, Fernando A Wilson, Jim P Stimpson, Hongmei Wang, David W Palm, Baojiang Chen, Li-Wu Chen
OBJECTIVE: The aim of this study is to examine differences in having preventable emergency department (ED) visits between noncitizens, naturalized and US-born citizens in the United States. METHODS: We linked the 2008-2012 Medical Expenditure Panel Survey with National Health Interview Survey data to draw a nationally representative sample of US adults. Univariate analysis described distribution of preventable ED visits identified by the Prevention Quality Indicators across immigration status...
August 7, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28814122/flibanserin-toxicity-in-a-toddler-following-ingestion
#9
Nicholas Granzella, Betty C Chen, Geoffrey S Baird, Matthew Valento
INTRODUCTION: Flibanserin is a medication recently approved by the FDA for treatment of generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. Its mechanism of action is not fully understood but is thought to modulate serotonin receptors and increase levels of norepinephrine and dopamine. While much is known about toxicity of other drugs which affect these systems, there is little information about toxicity of flibanserin at this time. CASE: We present a case of a 2-year-old boy who ingested an estimated 600 mg of his mother's flibanserin...
August 17, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28810576/application-of-low-dose-dual-source-computed-tomography-angiography-in-children-with-complex-congenital-heart-disease
#10
Xian-Feng Chen, Fan Jiang, Lin Li, Yan Chen, Xin Chen, Yan-Yan Jiang, Li Xiang, Xiao-Jing Ma
The objective of the present study was to evaluate image quality and radiation dosage using a low-dose prospectively electrocardiogram (ECG)-gated computed tomography (CT) protocol for dual-source angiography in children with complex congenital heart disease. A total of 206 patients with complex congenital heart disease were equally assigned into two groups at random. The children in group A underwent low-dose retrospective ECG-gated CT scanning with an ECG-pulsing technique, and group B underwent prospective ECG-gated scanning with an ECG-pulsing technique...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28798798/the-protective-effect-of-salidroside-on-hypoxia-induced-corpus-cavernosum-smooth-muscle-cell-phenotypic-transformation
#11
Xiang Zhang, Jian-Feng Zhao, Fan Zhao, Jun-Feng Yan, Fan Yang, Xiao-Jun Huang, Gang Chen, Hui-Ying Fu, Bo-Dong Lv
Salidroside, a major active ingredient isolated from Rhodiola rosea, has a long application in Chinese medical history. It has widely demonstrated effects on fatigue, psychological stress, and depression and exhibits potential antihypoxia activity. Emerging evidence shows that hypoxia is an important independent risk factor for erectile dysfunction (ED). The aim of this study was to clarify the effect of salidroside on hypoxia-induced phenotypic transformation of corpus cavernosum smooth muscle cells (CCSMCs)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28790990/ammonia-oxidizing-archaea-are-more-resistant-than-denitrifiers-to-seasonal-precipitation-changes-in-an-acidic-subtropical-forest-soil
#12
Jie Chen, Yanxia Nie, Wei Liu, Zhengfeng Wang, Weijun Shen
Seasonal precipitation changes are increasingly severe in subtropical areas. However, the responses of soil nitrogen (N) cycle and its associated functional microorganisms to such precipitation changes remain unclear. In this study, two projected precipitation patterns were manipulated: intensifying the dry-season drought (DD) and extending the dry-season duration (ED) but increasing the wet-season storms following the DD and ED treatment period. The effects of these two contrasting precipitation patterns on soil net N transformation rates and functional gene abundances were quantitatively assessed through a resistance index...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28790144/impact-of-physician-navigators-on-productivity-indicators-in-the-ed
#13
Alexander K Leung, Gaurav Puri, Bingshu E Chen, Zhenxian Gong, Eddie Chan, Edward Feng, Marko Duic
OBJECTIVES: We created Physician Navigators in our ED to help improve emergency physician (EP) productivity. We aimed to quantify the effect of Physician Navigators on measures of EP productivity: patient seen per hour (Pt/hr), and turn-around time (TAT) to discharge. Secondary objectives included examining their impact on measures of ED throughput for non-resuscitative patients: ED length of stay (LOS), door-to-physician time and left-without-being-seen rates (LWBS). METHODS: In this retrospective study, 6845 clinical shifts worked by 20 EPs at a community ED in Newmarket, Canada from 1 January 2012 to 31 March 2015 were evaluated...
August 8, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28781299/an-analysis-of-emergency-department-visits-and-the-survival-rate-for-colorectal-cancer-patients-a-nationwide-population-based-study
#14
Pei-Ling Tang, Hong-Tai Chang, Chin-Chang Cheng, Hung-Chih Chen, Shyh-Ming Kuo, Kuan-Yin Hsiao, Kuo-Chen Chang
Objective We examined the general characteristics, survival rate, and most common reasons for visiting the emergency department (ED) among colorectal cancer patients in Taiwan. We performed a population-based retrospective study and used data sourced from the National Health Insurance Research Database (NHIRD). Methods The colorectal cancer patient population, their diagnosis, and their medical management at the ED were identified using the Longitudinal Health Insurance Database 2000 (HV) codes and International Classification of Diseases, Ninth Revision, Clinical Modification system...
August 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28781215/adipose-derived-stem-cell-derived-exosomes-ameliorate-erectile-dysfunction-in-a-rat-model-of-type-2-diabetes
#15
Fengzhi Chen, Haibo Zhang, Zhiqiang Wang, Wei Ding, Qinyu Zeng, Wenbing Liu, Can Huang, Shuhua He, Anyang Wei
BACKGROUND: The efficacy of adipose-derived stem cells (ADSCs) in alleviating erectile dysfunction (ED) of diabetic rats has been demonstrated mainly through a paracrine effect. However, exosomes (EXOs), which are important bioactive substance vectors secreted by ADSCs, have never been associated with ED. AIM: To investigate the effect of ADSC-derived EXOs on erectile function in a type 2 diabetic ED rat model. METHODS: EXOs were isolated from the supernatants of cultured ADSCs by ultracentrifugation...
August 3, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28763467/effects-of-tnf-%C3%AE-on-penile-structure-alteration-in-rats-with-hyperprolactinemia
#16
Zhong-Lin Wang, Ling-Yu Yang, Hong-Huan Chen, Hsiao-Hsin Lin, Yi-Ting Tsai, William J Huang
This study aimed to investigate the effects of anti-tumor necrosis factor (TNF)-α antibody (Ab) on alteration of penile structure in the hyperprolactinemia (hyperPRL) rat model. HyperPRL was induced in 8-week-old male Sprague-Dawley rats by allografting anterior pituitary (AP) glands under the renal capsule (+AP rats). Rats implanted with cerebral cortex (CX) were used as sham control (+CX rats). At 6 weeks post implantation, rats received either a single intra-testicular dose of TNF-α Ab (12.5 μg/kg) or testosterone replacement (2 doses of testosterone enanthate [TE], 3 mg/kg), and they were sacrificed 1 week later...
2017: PloS One
https://www.readbyqxmd.com/read/28756082/asthma-morbidity-comorbidities-and-modifiable-factors-among-older-adults
#17
Joy Hsu, Jessica Chen, Maria C Mirabelli
BACKGROUND: Asthma morbidity is increased among older adults, especially older adult women. Interventions to improve asthma control in this population are not well described. OBJECTIVE: The objective of this study was to identify risk factors (including modifiable factors) associated with asthma-related hospitalizations and emergency department or urgent care center visits (ED/UCV) among older adults. A secondary objective was to investigate sex differences in variables relevant to asthma control...
July 19, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28753786/tumor-xenografts-of-human-clear-cell-renal-cell-carcinoma-but-not-corresponding-cell-lines-recapitulate-clinical-response-to-sunitinib-feasibility-of-using-biopsy-samples
#18
Yiyu Dong, Brandon J Manley, Maria F Becerra, Almedina Redzematovic, Jozefina Casuscelli, Daniel M Tennenbaum, Ed Reznik, Song Han, Nicole Benfante, Ying-Bei Chen, Maria E Arcila, Omer Aras, Martin H Voss, Darren R Feldman, Robert J Motzer, Nicola Fabbri, John H Healey, Patrick J Boland, Mohit Chawla, Jeremy C Durack, Chung-Han Lee, Jonathan A Coleman, Paul Russo, A Ari Hakimi, Emily H Cheng, James J Hsieh
BACKGROUND: Parallel development of preclinical models that recapitulate treatment response observed in patients is central to the advancement of personalized medicine. OBJECTIVE: To evaluate the use of biopsy specimens to develop patient-derived xenografts and the use of corresponding cell lines from renal cell carcinoma (RCC) tumors for the assessment of histopathology, genomics, and treatment response. DESIGN, SETTING, AND PARTICIPANTS: A total of 74 tumor specimens from 66 patients with RCC were implanted into immunocompromised NOD-SCID IL2Rg(-/-) mice...
August 25, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28726952/porphyra-polysaccharide-derived-carbon-dots-for-non-viral-co-delivery-of-different-gene-combinations-and-neuronal-differentiation-of-ectodermal-mesenchymal-stem-cells
#19
Jiaxin Chen, Qiang Wang, Jie Zhou, Wenwen Deng, Qingtong Yu, Xia Cao, Jianping Wang, Fengxia Shao, Yang Li, Ping Ma, Myron Spector, Jiangnan Yu, Ximing Xu
In this study, multifunctional fluorescent carbon dots (CDs) were synthesized using a one-pot hydrothermal carbonization reaction, with the naturally-occurring porphyra polysaccharide (PPS) serving as a single carbon source for the first time and ethylenediamine (Ed) acting as the surface passivation agent. The resulting CDs enjoyed a high quantum yield (56.3%), excitation-dependent fluorescence, small size (<10 nm), spherical shape, uniform distribution, positive surface charge, low cytotoxicity and excellent ability to condense macromolecular plasmid DNA...
August 3, 2017: Nanoscale
https://www.readbyqxmd.com/read/28701158/endotoxemia-is-associated-with-acute-coronary-syndrome-in-patients-with-end-stage-kidney-disease
#20
Chien-Chin Hsu, Tsui-Shan Wei, Chien-Cheng Huang, Yi-Ming Chen
BACKGROUND: Cardiovascular disease is the major cause of death in patients with end-staged kidney disease (ESRD). Most ESRD patients have systemic inflammation, and increasing the risk of cardiovascular event. Endotoxin derived from lipopolysaccharide of Gram negative bacteria accounts for 70% of intestinal bacteria, leading to release of proinflammatory cytokines and negative cardiovascular effect. Impaired intestinal barriers have been found in some ESRD patients, and may lead to bacteria translocation from gastrointestinal tract...
July 12, 2017: BMC Nephrology
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