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Ed Chen

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https://www.readbyqxmd.com/read/27906675/preoperative-serum-pre-albumin-as-an-independent-prognostic-indicator-in-patients-with-localized-upper-tract-urothelial-carcinoma-after-radical-nephroureterectomy
#1
Jiwei Huang, Yanqing Wang, Yichu Yuan, Yong-Hui Chen, Wen Kong, Haige Chen, Jin Zhang, Yiran Huang
PURPOSE: To investigate the prognostic value of preoperative pre-albumin and albumin level in patients with localized upper tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy. METHODS AND MATERIALS: Between January 2003 and June 2013, we evaluated data on 425 patients with nonmetastatic UTUC (Ta-4N0/+M0) who underwent radical nephroureterectomy at our institution. Low pre-albumin level was defined as <20 mg/dl, while hypoalbuminemia was defined as albumin <35 g/L...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27876028/clinical-assessment-of-children-with-renal-abscesses-presenting-to-the-pediatric-emergency-department
#2
Chun-Yu Chen, Huang-Tsung Kuo, Yu-Jun Chang, Kang-Hsi Wu, Wen-Chieh Yang, Han-Ping Wu
BACKGROUND: Renal abscesses are relatively uncommon in children but may result in prolonged hospital stays and life-threatening events. We undertook this study to analyze the clinical spectrum of renal abscesses in children admitted to the pediatric emergency department (ED) and to find helpful clinical characteristics that can potentially aid emergency physicians for detecting renal abscesses in children earlier. METHODS: From 2004 to 2011, we retrospectively analyzed 17 patients, aged 18 years or younger, with a definite diagnosis of renal abscess admitted to the ED...
November 22, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27861836/out-of-network-emergency-department-use-among-managed-medicaid-beneficiaries
#3
Maria C Raven, David Guzman, Alice H Chen, John Kornak, Margot Kushel
OBJECTIVE: Out-of-network emergency department (ED) use, or use that occurs outside the contracted network, may lead to increased care fragmentation and cost. We examined factors associated with out-of-network ED use among Medicaid beneficiaries. DATA SOURCES AND STUDY SETTING: Enrollment, claims, and encounter data for adult Medi-Cal health plan members with 1+ ED visits and complete Medicaid eligibility during the study period from 2013 to 2014. STUDY DESIGN: We analyzed the data to identify factors associated with out-of-network ED use classified by mode of arrival (ambulance vs...
November 11, 2016: Health Services Research
https://www.readbyqxmd.com/read/27856020/the-effect-of-bedside-ultrasonographic-skin-marking-on-infant-lumbar-puncture-success-a%C3%A2-randomized-controlled-trial
#4
Jeffrey T Neal, Summer L Kaplan, Ashley L Woodford, Krisha Desai, Joseph J Zorc, Aaron E Chen
STUDY OBJECTIVE: Lumbar puncture is a commonly performed procedure, although previous studies have documented low rates of successful completion in infants. Ultrasonography can visualize the anatomic landmarks for lumbar puncture and has been shown in some studies to reduce the failure rate of lumbar puncture in adults. We seek to determine whether ultrasonography assisted site marking increases success for infant lumbar punctures. METHODS: This was a prospective, randomized, controlled trial in an academic pediatric emergency department (ED)...
November 14, 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27852014/the-incidence-of-pressure-ulcers-in-the-emergency-department-a-metaanalysis
#5
Peng Liu, Wang-Qin Shen, Hong-Lin Chen
OBJECTIVE: The aim of this meta-analysis was to estimate the incidence of pressure ulcers (PUs) in the emergency department (ED). METHODS: The authors searched PubMed, Web of Science, and CINAHL databases for all time leading up to February 2016. The incidence of PUs in the ED were collected, and the pooled incidence with 95% confidence interval (CI) was calculated by meta-analysis. RESULTS: Six studies with 8 cohorts were included in this study...
October 24, 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27832977/development-and-validation-of-a-parsimonious-and-pragmatic-charm-score-to-predict-mortality-in-patients-with-suspected-sepsis
#6
Kuan-Fu Chen, Su-Hsun Liu, Chih-Huang Li, Chin-Chieh Wu, Chung-Hsien Chaou, I-Shiang Tzeng, Yu-Hsiang Hsieh, Gerald N Blaney, Zhen-Ying Liu, Shih-Tsung Han, Yi-Lin Chan
BACKGROUND: We aimed to derive and validate a parsimonious and pragmatic clinical prediction rule using the concepts of Predisposition, Infection, Response, and Organ Dysfunction to predict in-hospital mortality; and to compare it with other prediction rules, as well as with conventional biomarkers for evaluating the mortality risk of patients with suspected sepsis in the emergency department (ED). METHODS: We conducted a pragmatic cohort study with consecutive ED patients aged 18 or older with documented diagnostic codes of infection and two sets of blood culture ordered by physicians between 2010 and 2012 in a tertiary teaching hospital...
November 3, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27789567/variables-associated-with-administration-of-analgesia-nurse-initiated-analgesia-and-early-analgesia-in-the-emergency-department
#7
David McD Taylor, Jessie Chen, Munad Khan, Marina Lee, Mani Rajee, Michael Yeoh, Joanna R Richardson, Antony M Ugoni
OBJECTIVE: To determine the patient and clinical variables associated with administration of any analgesia, nurse-initiated analgesia (NIA, prescribed and administered by a nurse) and early analgesia (within 30 min of presentation). METHODS: We undertook a retrospective cohort study of patients who presented to a metropolitan ED in Melbourne, Australia, during July and August, 2013. The ED has an established NIA programme. Patients were included if they were aged 18 years or more and presented with a painful complaint...
October 27, 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27789203/radiation-optimized-dual-source-dual-energy-computed-tomography-pulmonary-angiography-intra-individual-and-inter-individual-comparison
#8
Xie Li, Guo Zhong Chen, Yan E Zhao, U Joseph Schoepf, Moritz H Albrecht, Matthew W Bickford, Hai Feng Gu, Long Jiang Zhang, Guang Ming Lu
OBJECTIVES: This study aimed to intra-individually and inter-individually compare image quality, radiation dose, and diagnostic accuracy of dual-source dual-energy computed tomography pulmonary angiography (CTPA) protocols in patients with suspected pulmonary embolism (PE). METHODS: Thirty-three patients with suspected PE underwent initial and follow-up dual-energy CTPA at 80/Sn140 kVp (group A) or 100/Sn140 kVp (group B), which were assigned based on tube voltages...
October 24, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27788237/comparison-of-128-slice-low-dose-prospective-ecg-gated-ct-scanning-and-trans-thoracic-echocardiography-for-the-diagnosis-of-complex-congenital-heart-disease
#9
Guilin Bu, Ying Miao, Jingwen Bin, Sheng Deng, Taowen Liu, Hongchun Jiang, Weiping Chen
OBJECTIVE: To compare prospective ECG-gated multi-slice computed tomography (MSCT) and trans-thoracic echocardiography (TTE) in the diagnosis of complex congenital heart disease (CHD). METHODS: This was a prospective study of consecutive patients with complex CHD (age <7 years) treated at a tertiary hospital between May 2013 and May 2015. All patients were imaged with TTE and prospective ECG-gated 128-slice spiral CT in the week before surgery. Effective radiation dose (ED) was calculated from volume CT dose index (CTDIvol) and dose length product (DLP)...
2016: PloS One
https://www.readbyqxmd.com/read/27772704/construction-of-surface-ha-tio2-coating-on-porous-titanium-scaffolds-and-its-preliminary-biological-evaluation
#10
Hongjie Chen, Chunli Wang, Xiao Yang, Zhanwen Xiao, Xiangdong Zhu, Kai Zhang, Yujiang Fan, Xingdong Zhang
A simple approach to fabricating hydroxyxapatite/titanium dioxide (HA/TiO2) coating on porous titanium (Ti) scaffolds was developed in the present study. Surface TiO2 layer was firstly formed on porous Ti scaffolds with multi-scale pores by acid-alkali (AA) treatment. The outer HA layer was then formed on the TiO2 layer by subsequent pulse electrochemical deposition (ED) technique. All the three main process parameters, i.e. deposition times, current density and mass transfer mode affected the properties of the HA coating notably...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27770307/some-remarks-on-applications-of-tests-for-detecting-a-change-point-to-psychometric-problems
#11
Sandip Sinharay
Tests for a change point (e.g., Chen and Gupta, Parametric statistical change point analysis (2nd ed.). Birkhuser, Boston, 2012; Hawkins et al., J Qual Technol 35:355-366, 2003) have recently been brought into the spotlight for their potential uses in psychometrics. They have been successfully applied to detect an unusual change in the mean score of a sequence of administrations of an international language assessment (Lee and von Davier, Psychometrika 78:557-575, 2013) and to detect speededness of examinees (Shao et al...
October 21, 2016: Psychometrika
https://www.readbyqxmd.com/read/27769308/the-modified-save-score-predicting-survival-using-urgent-veno-arterial-extracorporeal-membrane-oxygenation-within-24%C3%A2-hours-of-arrival-at-the-emergency-department
#12
Wei-Cheng Chen, Kuo-Yang Huang, Chih-Wei Yao, Cing-Feng Wu, Shinn-Jye Liang, Chia-Hsiang Li, Chih-Yeh Tu, Hung-Jen Chen
BACKGROUND: Although many risk models have been tested in patients who undergo extracorporeal membrane oxygenation, few have been assessed for patients who received veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support in the emergency department (ED). This study aimed to successfully predict outcomes of patients with cardiac or noncardiac failure who received VA-ECMO in the ED within 24 hours of arrival at the ED. METHOD: This retrospective, observational cohort study included 154 patients, who were classified as cardiac (n = 127) and noncardiac (n = 27) patients and received VA-ECMO within 24 hours after arrival at the China Medical University Hospital ED in Taiwan between January 2009 and September 2014...
October 22, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27759626/impact-of-performance-grading-on-annual-numbers-of-acute-myocardial-infarction-associated-emergency-department-visits-in-taiwan-results-of-segmented-regression-analysis
#13
I-Shiang Tzeng, Su-Hsun Liu, Kuan-Fu Chen, Chin-Chieh Wu, Jih-Chang Chen
To reduce patient boarding time at the emergency department (ED) and to improve the overall quality of the emergent care system in Taiwan, the Minister of Health and Welfare of Taiwan (MOHW) piloted the Grading Responsible Hospitals for Acute Care (GRHAC) audit program in 2007-2009.The aim of the study was to evaluate the impact of the GRHAC audit program on the identification and management of acute myocardial infarction (AMI)-associated ED visits by describing and comparing the incidence of AMI-associated ED visits before (2003-2007), during (2007-2009), and after (2009-2012) the initial audit program implementation...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27736875/mutations-in-tspear-encoding-a-regulator-of-notch-signaling-affect-tooth-and-hair-follicle-morphogenesis
#14
Alon Peled, Ofer Sarig, Liat Samuelov, Marta Bertolini, Limor Ziv, Daphna Weissglas-Volkov, Marina Eskin-Schwartz, Christopher A Adase, Natalia Malchin, Ron Bochner, Gilad Fainberg, Ilan Goldberg, Koji Sugawara, Avital Baniel, Daisuke Tsuruta, Chen Luxenburg, Noam Adir, Olivier Duverger, Maria Morasso, Stavit Shalev, Richard L Gallo, Noam Shomron, Ralf Paus, Eli Sprecher
Despite recent advances in our understanding of the pathogenesis of ectodermal dysplasias (EDs), the molecular basis of many of these disorders remains unknown. In the present study, we aimed at elucidating the genetic basis of a new form of ED featuring facial dysmorphism, scalp hypotrichosis and hypodontia. Using whole exome sequencing, we identified 2 frameshift and 2 missense mutations in TSPEAR segregating with the disease phenotype in 3 families. TSPEAR encodes the thrombospondin-type laminin G domain and EAR repeats (TSPEAR) protein, whose function is poorly understood...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27733674/interhospital-transfer-neurological-deterioration-in-patients-with-spontaneous-intracerebral-haemorrhage-incidence-and-risk-factors
#15
Ju-Sing Fan, Yen-Chia Chen, Hsien-Hao Huang, David Hung-Tsang Yen, Chorng-Kuang How, Mu-Shuan Huang
OBJECTIVE: To explore the incidence and risk factors for interhospital transfer neurological deterioration (IHTND) in patients with spontaneous intracerebral haemorrhage (SICH). METHODS: Consecutive adult patients with first-ever SICH referred to our emergency department (ED) and transported by ambulance from July 2011 through June 2015 were eligible for this prospective observational study. Enrolled patients had SICH with elapsed time <12 hours and a nearly normal Glasgow Coma Scale (GCS) score (≥13) at presentation...
October 12, 2016: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/27725867/low-kilovoltage-peak-kvp-with-an-adaptive-statistical-iterative-reconstruction-algorithm-in-computed-tomography-urography-evaluation-of-image-quality-and-radiation-dose
#16
Zhiguo Zhou, Haixi Chen, Wei Wei, Shanghui Zhou, Jingbo Xu, Xifu Wang, Qingguo Wang, Guixiang Zhang, Zhuoli Zhang, Linfeng Zheng
PURPOSE: The purpose of this study was to evaluate the image quality and radiation dose in computed tomography urography (CTU) images acquired with a low kilovoltage peak (kVp) in combination with an adaptive statistical iterative reconstruction (ASiR) algorithm. METHODS: A total of 45 subjects (18 women, 27 men) who underwent CTU with kV assist software for automatic selection of the optimal kVp were included and divided into two groups (A and B) based on the kVp and image reconstruction algorithm: group A consisted of patients who underwent CTU with a 80 or 100 kVp and whose images were reconstructed with the 50% ASiR algorithm (n=32); group B consisted of patients who underwent CTU with a 120 kVp and whose images were reconstructed with the filtered back projection (FBP) algorithm (n=13)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27722580/on-describing-the-optoelectronic-characteristics-of-poly-benzodithiophene-co-quinoxaline-fullerene-complexes-the-influence-of-optimally-tuned-density-functionals
#17
T Kastinen, M Niskanen, C Risko, O Cramariuc, T I Hukka
Here, we investigate the effects of both tuning the range-separation parameter of long-range corrected (LRC) density functionals and including dispersion corrections on describing the local optoelectronic properties of polymer-fullerene interfaces that are critical to the performance of polymer solar cells (PSCs). Focusing on recently studied (Chen, et al., Chem. Mater., 2012, 24, 4766-4772) PSC active layers derived from poly(benzodithiophene-co-quinoxaline) and substituted fullerene PC71BM, we compare the performance of global hybrid functionals (B3LYP and B3LYP-D) alongside two LRC functionals (ωB97X and ωB97X-D) and their optimally tuned (OT) analogs (OT-ωB97X and OT-ωB97X-D)...
October 5, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27720452/kinetic-analysis-of-protein-stability-reveals-age-dependent-degradation
#18
Erik McShane, Celine Sin, Henrik Zauber, Jonathan N Wells, Neysan Donnelly, Xi Wang, Jingyi Hou, Wei Chen, Zuzana Storchova, Joseph A Marsh, Angelo Valleriani, Matthias Selbach
Do young and old protein molecules have the same probability to be degraded? We addressed this question using metabolic pulse-chase labeling and quantitative mass spectrometry to obtain degradation profiles for thousands of proteins. We find that >10% of proteins are degraded non-exponentially. Specifically, proteins are less stable in the first few hours of their life and stabilize with age. Degradation profiles are conserved and similar in two cell types. Many non-exponentially degraded (NED) proteins are subunits of complexes that are produced in super-stoichiometric amounts relative to their exponentially degraded (ED) counterparts...
October 20, 2016: Cell
https://www.readbyqxmd.com/read/27709655/elevated-serum-homocysteine-level-as-an-independent-risk-factor-for-erectile-dysfunction-a-prospective-pilot-case-control-study
#19
Z Zhang, Z Xu, Y Dai, Y Chen
Homocysteine is an amino acid that is produced from the metabolic demethylation of dietary methionine. It has gained arising attention for its association with increased risk of myocardial infarction, stroke and venous thromboembolism. Erectile dysfunction (ED), especially for vasculogenic ED, is a vascular disorder of cavernosal vascular bed. In this prospective pilot case-control study, we investigated plasma homocysteine levels in 32 ED patients and 20 healthy control men. Related patients characteristics including age, weight, height, marital status, smoking and drinking status, level of education were collected and analysed as well as penile colour Doppler ultrasound parameters...
October 6, 2016: Andrologia
https://www.readbyqxmd.com/read/27640304/evidence-that-the-5p12-variant-rs10941679-confers-susceptibility-to-estrogen-receptor-positive-breast-cancer-through-fgf10-and-mrps30-regulation
#20
Maya Ghoussaini, Juliet D French, Kyriaki Michailidou, Silje Nord, Jonathan Beesley, Sander Canisus, Kristine M Hillman, Susanne Kaufmann, Haran Sivakumaran, Mahdi Moradi Marjaneh, Jason S Lee, Joe Dennis, Manjeet K Bolla, Qin Wang, Ed Dicks, Roger L Milne, John L Hopper, Melissa C Southey, Marjanka K Schmidt, Annegien Broeks, Kenneth Muir, Artitaya Lophatananon, Peter A Fasching, Matthias W Beckmann, Olivia Fletcher, Nichola Johnson, Elinor J Sawyer, Ian Tomlinson, Barbara Burwinkel, Frederik Marme, Pascal Guénel, Thérèse Truong, Stig E Bojesen, Henrik Flyger, Javier Benitez, Anna González-Neira, M Rosario Alonso, Guillermo Pita, Susan L Neuhausen, Hoda Anton-Culver, Hermann Brenner, Volker Arndt, Alfons Meindl, Rita K Schmutzler, Hiltrud Brauch, Ute Hamann, Daniel C Tessier, Daniel Vincent, Heli Nevanlinna, Sofia Khan, Keitaro Matsuo, Hidemi Ito, Thilo Dörk, Natalia V Bogdanova, Annika Lindblom, Sara Margolin, Arto Mannermaa, Veli-Matti Kosma, Anna H Wu, David Van Den Berg, Diether Lambrechts, Giuseppe Floris, Jenny Chang-Claude, Anja Rudolph, Paolo Radice, Monica Barile, Fergus J Couch, Emily Hallberg, Graham G Giles, Christopher A Haiman, Loic Le Marchand, Mark S Goldberg, Soo H Teo, Cheng Har Yip, Anne-Lise Borresen-Dale, Wei Zheng, Qiuyin Cai, Robert Winqvist, Katri Pylkäs, Irene L Andrulis, Peter Devilee, Rob A E M Tollenaar, Montserrat García-Closas, Jonine Figueroa, Per Hall, Kamila Czene, Judith S Brand, Hatef Darabi, Mikael Eriksson, Maartje J Hooning, Linetta B Koppert, Jingmei Li, Xiao-Ou Shu, Ying Zheng, Angela Cox, Simon S Cross, Mitul Shah, Valerie Rhenius, Ji-Yeob Choi, Daehee Kang, Mikael Hartman, Kee Seng Chia, Maria Kabisch, Diana Torres, Craig Luccarini, Don M Conroy, Anna Jakubowska, Jan Lubinski, Suleeporn Sangrajrang, Paul Brennan, Curtis Olswold, Susan Slager, Chen-Yang Shen, Ming-Feng Hou, Anthony Swerdlow, Minouk J Schoemaker, Jacques Simard, Paul D P Pharoah, Vessela Kristensen, Georgia Chenevix-Trench, Douglas F Easton, Alison M Dunning, Stacey L Edwards
Genome-wide association studies (GWASs) have revealed increased breast cancer risk associated with multiple genetic variants at 5p12. Here, we report the fine mapping of this locus using data from 104,660 subjects from 50 case-control studies in the Breast Cancer Association Consortium (BCAC). With data for 3,365 genotyped and imputed SNPs across a 1 Mb region (positions 44,394,495-45,364,167; NCBI build 37), we found evidence for at least three independent signals: the strongest signal, consisting of a single SNP rs10941679, was associated with risk of estrogen-receptor-positive (ER(+)) breast cancer (per-g allele OR ER(+) = 1...
October 6, 2016: American Journal of Human Genetics
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