Roy Rampling, Sharon Peoples, Paul J Mulholland, Allan James, Omar Al-Salihi, Christopher J Twelves, Catherine McBain, Sarah Jefferies, Alan Jackson, Willie Stewart, Juha Lindner, Sarah Kutscher, Norbert Hilf, Lesley McGuigan, Jane Peters, Karen Hill, Oliver Schoor, Harpreet Singh-Jasuja, Sarah E Halford, James W A Ritchie
PURPOSE: To perform a two-cohort, phase I safety and immunogenicity study of IMA950 in addition to standard chemoradiotherapy and adjuvant temozolomide in patients with newly diagnosed glioblastoma. IMA950 is a novel glioblastoma-specific therapeutic vaccine containing 11 tumor-associated peptides (TUMAP), identified on human leukocyte antigen (HLA) surface receptors in primary human glioblastoma tissue. EXPERIMENTAL DESIGN: Patients were HLA-A*02-positive and had undergone tumor resection...
October 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research