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https://www.readbyqxmd.com/read/29770251/review-of-the-neurological-benefits-of-phytocannabinoids
#1
REVIEW
Joseph Maroon, Jeff Bost
Background: Numerous physical, psychological, and emotional benefits have been attributed to marijuana since its first reported use in 2,600 BC in a Chinese pharmacopoeia. The phytocannabinoids, cannabidiol (CBD), and delta-9-tetrahydrocannabinol (Δ9-THC) are the most studied extracts from cannabis sativa subspecies hemp and marijuana. CBD and Δ9-THC interact uniquely with the endocannabinoid system (ECS). Through direct and indirect actions, intrinsic endocannabinoids and plant-based phytocannabinoids modulate and influence a variety of physiological systems influenced by the ECS...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29719729/influence-of-playing-rugby-on-long-term-brain-health-following-retirement-a-systematic-review-and-narrative-synthesis
#2
Joice Cunningham, Steven Broglio, Fiona Wilson
Objectives: The aim of this review was to systematically investigate long-term brain health in retired rugby players. Methods: Six databases were systematically searched from inception to January 2018 using Medical Subject Headings and keywords. Two reviewers independently screened studies for inclusion. Cross-sectional studies of living retired male or female rugby players in which at least one cognitive test was used as an outcome measure were included. Data extraction was performed using Strengthening the Reporting of Observational Studies in Epidemiology guidelines...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29710088/safety-of-osteopathic-cranial-manipulative-medicine-as-an-adjunct-to-conventional-postconcussion-symptom-management-a-pilot-study
#3
Komal G Patel, Rosanna C Sabini
Context: Osteopathic cranial manipulative medicine is not a well-established adjunct to conventional treatment for patients with postconcussion symptoms. Objective: To determine whether adjunctive osteopathic cranial manipulative medicine is safe for patients with concussion when accompanied by conventional treatments. Design: Prospective observational pilot study. Setting: Outpatient concussion clinic. Participants: Patients who sustained a concussion were prospectively recruited from an outpatient concussion clinic by a neuropsychologist specialized in concussion...
April 16, 2018: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29709522/feasibility-and-preliminary-validation-of-an-online-version-of-the-ohio-state-university-traumatic-brain-injury-identification-method
#4
Anthony H Lequerica, Christian Lucca, Nancy D Chiaravalloti, Irene Ward, John D Corrigan
OBJECTIVE: To test the feasibility and validity of an online version of an established interview designed to determine a lifetime history of traumatic brain injury. DESIGN: Cross-sectional SETTING: General community PARTICIPANTS: A volunteer sample of 265 individuals from the general population across the U.S. INTERVENTIONS: Not applicable MAIN OUTCOME MEASURE(S): Online version of the Ohio State University Traumatic Brain Injury Identification Method, Rivermead Postconcussion Symptoms Questionnaire (RPQ), PROMIS Cognitive Concerns Scale RESULTS: The measure was completed by 89...
April 27, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29694459/characterizing-hospitalizations-for-pediatric-concussion-and-trends-in-care
#5
Tara Rhine, Terri Byczkowski, Mekibib Altaye, Shari L Wade, Lynn Babcock
BACKGROUND: Children hospitalized for concussion may be at a higher risk for persistent symptoms, but little is known about this subset of children. OBJECTIVE: Delineate a cohort of children admitted for concussion, describe care practices received, examine factors associated with prolonged length of stay (LOS) or emergency department (ED) readmission, and investigate changes in care over time. DESIGN, SETTING: Retrospective analysis of data submitted by 40 pediatric hospitals to the Pediatric Health Information System...
April 25, 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29665736/fear-avoidance-and-clinical-outcomes-from-mild-traumatic-brain-injury
#6
Noah D Silverberg, William Panenka, Grant L Iverson
Characterizing psychological factors that contribute to persistent symptoms after mild traumatic brain injury (MTBI) can inform early intervention. To determine whether fear avoidance, a known risk factor for chronic disability after musculoskeletal injury, is associated with worse clinical outcomes from MTBI, adults were recruited from four outpatient MTBI clinics and assessed at their first clinic visit (M=2.7, SD=1.5 weeks post-injury) and again 4-5 months later. Of 273 patients screened, 102 completed the initial assessment and 87 returned for the outcome assessment...
April 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29629181/comparison-of-baseline-and-postconcussion-scat3-scores-and-symptoms-in-varsity-athletes-an-investigation-into-differences-by-sex-and-history-of-concussion
#7
Johanna M Hurtubise, Cindy E Hughes, Lauren E Sergio, Alison K Macpherson
Objective: To investigate the use of the Sport Concussion Assessment Tool 3 (SCAT3) as an assessment tool in the varsity population, as well as the effects of sex and concussion history on both baseline and postconcussion scores. Methods: A comparison between baseline and postconcussion SCAT3 scores of varsity level athletes was conducted through retrospective chart review. Differences in both baseline and postconcussion scores were further analysed by sex and history of concussion...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29621016/impact-normative-data-of-ethnically-diverse-adolescent-athletes
#8
William T Tsushima, Vincent G Tsushima, Nathan M Murata
OBJECTIVE: The aim of this research was to develop preliminary norms for the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) administered to a large sample of adolescent athletes from diverse ethnic backgrounds. DESIGN: A retrospective records review. SETTING: Middle and high school athletic departments. PARTICIPANTS: A total of 5741 male and female adolescent athletes in Hawaii, aged 13 to 18 years, in grades 9 to 12 were included in the study...
April 4, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29601343/a-preliminary-investigation-of-accelerometer-derived-sleep-and-physical-activity-following-sport-related-concussion
#9
Alicia M Sufrinko, Erin K Howie, R J Elbin, Michael W Collins, Anthony P Kontos
OBJECTIVE: Describe changes in postconcussion activity levels and sleep throughout recovery in a sample of pediatric sport-related concussion (SRC) patients, and examine the predictive value of accelerometer-derived activity and sleep on subsequent clinical outcomes at a follow-up clinic visit. SETTING: Outpatient concussion clinic. PARTICIPANTS: Twenty athletes aged 12 to 19 years with diagnosed SRC. METHODS: Prospective study including visit 1 (<72 hours postinjury) and visit 2 (6-18 days postinjury)...
March 29, 2018: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/29581986/negative-mood-states-correlate-with-laterobasal-amygdala-in-collegiate-football-players
#10
Han Byul Cho, Charles Elliott Bueler, Jennifer DiMuzio, Charlie Hicks-Little, Erin McGlade, In Kyoon Lyoo, Deborah Yurgelun-Todd
A number of studies have suggested that sports-related concussion (SRC) may place individuals at increased risk for depression and negative outcomes including suicide. However, the mechanisms underlying a potential relationship between brain integrity and mood remain unclear. The current study is aimed at examining the association between amygdala shape, mood state, and postconcussion symptoms in collegiate football players. Thirty members of 1 football team completed the Profile of Mood States (POMS), the postconcussion symptom scale (PCSS), and an MRI protocol during preseason camp...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29554536/postconcussive-symptoms-pcs-following-combat-related-traumatic-brain-injury-tbi-in-veterans-with-posttraumatic-stress-disorder-ptsd-influence-of-tbi-ptsd-and-depression-on-symptoms-measured-by-the-neurobehavioral-symptom-inventory-nsi
#11
Katherine E Porter, Murray B Stein, Brian Martis, Kimberly M Avallone, Lauren B McSweeney, Erin R Smith, Naomi M Simon, Sean Gargan, Israel Liberzon, Charles W Hoge, Sheila A M Rauch
Mild traumatic brain injury (mTBI) is commonly reported in recent combat Veterans. While the majority resolve, some Veterans develop postconcussive symptoms (PCS). Previous research suggests these symptoms are not specific to head injury and are often associated with psychiatric symptoms. The current study examines the relative contributions of posttraumatic stress, depressive symptoms, and TBI on postconcussive symptoms, and explores whether the relationship remains after controlling for symptom overlap. Two hundred eighteen combat Veterans from Operation Iraqi Freedom (OIF), Operation Enduring Freedom (OEF), and Operation New Dawn (OND) provided the data for this study as part of a baseline evaluation for inclusion into larger treatment study for posttraumatic stress disorder (PTSD)...
March 10, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29552934/postconcussive-symptoms-after-single-and-repeated-concussions-in-10-to-20-year-olds-a-cross-sectional-study
#12
Temitayo Oyefunmike Oyegbile, Bronson Elizabeth Delasobera, Nassim Zecavati
The objective was to characterize cognitive deficits and postconcussive symptoms in a pediatric population with no concussion, a single concussion, and ≥2 concussions, using a cross-sectional design. Cognitive function and postconcussive symptoms were assessed in participants (age 10-20) with no concussion (n = 1118), single concussion (n = 368), and repeated (≥2) concussions (n = 252). Analyses were adjusted for age and gender. Individuals with ≥2 concussions exhibited more total postconcussive symptoms; more loss of consciousness, amnesia and confusion; more headaches; and poorer cognitive function compared to no concussion and single concussion...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29532050/prevalence-of-invalid-performance-on-baseline-testing-for-sport-related-concussion-by-age-and-validity-indicator
#13
Christopher A Abeare, Isabelle Messa, Brandon G Zuccato, Bradley Merker, Laszlo Erdodi
Importance: Estimated base rates of invalid performance on baseline testing (base rates of failure) for the management of sport-related concussion range from 6.1% to 40.0%, depending on the validity indicator used. The instability of this key measure represents a challenge in the clinical interpretation of test results that could undermine the utility of baseline testing. Objectives: To determine the prevalence of invalid performance on baseline testing and to assess whether the prevalence varies as a function of age and validity indicator...
March 12, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29517589/neuropsychological-performance-and-subjective-symptom-reporting-in-military-service-members-with-a-history-of-multiple-concussions-comparison-with-a-single-concussion-posttraumatic-stress-disorder-and-orthopedic-trauma
#14
Douglas B Cooper, Glenn Curtiss, Patrick Armistead-Jehle, Heather G Belanger, David F Tate, Matthew Reid, Amy O Bowles, Carmen S Velez, Jan E Kennedy, Rodney D Vanderploeg
OBJECTIVE: To examine differences in objective neurocognitive performance and subjective cognitive symptoms in individuals with a history of a single concussion, multiple concussions, orthopedic injuries, and posttraumatic stress disorder (PTSD). METHOD: Participants included 116 military service members who sustained a mild traumatic brain injury (mTBI) during combat deployment. Subjects were subdivided into groups based on concussion frequency: a single concussion (n = 42), 2 concussions (n = 21), and 3 or more concussions (n = 53)...
March 2018: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/29515515/chronic-hypopituitarism-associated-with-increased-postconcussive-symptoms-is-prevalent-after-blast-induced-mild-traumatic-brain-injury
#15
Arundhati Undurti, Elizabeth A Colasurdo, Carl L Sikkema, Jaclyn S Schultz, Elaine R Peskind, Kathleen F Pagulayan, Charles W Wilkinson
The most frequent injury sustained by US service members deployed to Iraq or Afghanistan is mild traumatic brain injuries (mTBI), or concussion, by far most often caused by blast waves from improvised explosive devices or other explosive ordnance. TBI from all causes gives rise to chronic neuroendocrine disorders with an estimated prevalence of 25-50%. The current study expands upon our earlier finding that chronic pituitary gland dysfunction occurs with a similarly high frequency after blast-related concussions...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29485429/valid-but-invalid-suboptimal-impact%C3%A2-baseline-performance-in-university-athletes
#16
Samuel R Walton, Donna K Broshek, Jason Freeman, C Munro Cullum, Jacob E Resch
PURPOSE: To investigate the frequency of valid yet suboptimal Immediate Postconcussion Assessment and Cognitive Test© (ImPACT) performance in university athletes and to explore the benefit of subsequent ImPACT administrations. METHODS: This descriptive laboratory study involved baseline administration of ImPACT to 769 university athletes per the institution's concussion management protocol. Testing was proctored in groups of ≤ 2 participants. Participants who scored below the 16th percentile according to ImPACT normative data were re-administered ImPACT up to two additional times as these scores were thought to be potentially indicative of suboptimal effort or poor understanding of instructions...
February 27, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29465268/convergent-and-discriminant-validity-of-the-immediate-postconcussion-assessment-and-cognitive-testing-battery-impact-in-young-athletes
#17
Lisa M Koehl, Brittany D Walls, Stacey L Brothers, Sarah N Morris, Amanda C Glueck, Frederick A Schmitt, David T R Berry, Dong Y Han
Sports concussions are recognized as significant injuries among young athletes. Research demonstrates that return-to-play prior to becoming asymptomatic has significant repercussions including sustained cognitive deficits. Many programs have begun to use computerized testing rather than traditional neuropsychological tests to (a) determine baseline performance, (b) track symptoms, and (c) measure symptoms following concussion. Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) is one such tool...
February 21, 2018: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/29432249/pediatric-traumatic-brain-injury-and-concussion
#18
Meeryo Choe, Karen M Barlow
PURPOSE OF REVIEW: This article summarizes the impact and complications of mild traumatic brain injury and concussion in children and outlines the recent evidence for its assessment and early management. Useful evidence-based management strategies are provided for children who have a typical recovery following concussion as well as for those who have persistent postconcussion syndrome. Cases are used to demonstrate the commonly encountered pathologies of headache, cognitive issues, and mood disturbances following injury...
February 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29431132/longitudinal-changes-in-oculomotor-function-in-young-adults-with-mild-traumatic-brain-injury-in-sweden-an-exploratory-prospective-observational-study
#19
Giedre Matuseviciene, Jan Johansson, Marika Möller, Alison K Godbolt, Tony Pansell, Catharina Nygren Deboussard
OBJECTIVES: To assess (1) whether visual disturbances can be demonstrated with objective measures more often in patients with mild traumatic brain injury (mTBI) than in orthopaedic controls and non-injured controls, (2) whether such objectively demonstrated disturbances change over time and (3) whether self-reported visual symptoms after mTBI correlate with objectively measurable changes in visuomotor performance. DESIGN: A prospective, controlled, observational study, with assessments planned 7-10 and 75-100 days after injury...
February 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29416525/patient-specific-alterations-in-co-2-cerebrovascular-responsiveness-in-acute-and-sub-acute-sports-related-concussion
#20
W Alan C Mutch, Michael J Ellis, Lawrence N Ryner, Patrick J McDonald, Marc P Morissette, Philip Pries, Marco Essig, David J Mikulis, James Duffin, Joseph A Fisher
Background: Preliminary studies suggest that sports-related concussion (SRC) is associated with alterations in cerebral blood flow (CBF) regulation. Here, we use advanced magnetic resonance imaging (MRI) techniques to measure CBF and cerebrovascular responsiveness (CVR) in individual SRC patients and healthy control subjects. Methods: 15 SRC patients (mean age = 16.3, range 14-20 years) and 27 healthy control subjects (mean age = 17.6, range 13-21 years) underwent anatomical MRI, pseudo-continuous arterial spin labeling (pCASL) MRI and model-based prospective end-tidal targeting (MPET) of CO2 during blood oxygenation level-dependent (BOLD) MRI...
2018: Frontiers in Neurology
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