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https://www.readbyqxmd.com/read/28538990/measuring-nonlinear-signal-combination-using-eeg
#1
Darren G M Cunningham, Daniel H Baker, Jonathan W Peirce
Relatively little is known about the processes, both linear and nonlinear, by which signals are combined beyond V1. By presenting two stimulus components simultaneously, flickering at different temporal frequencies (frequency tagging) while measuring steady-state visual evoked potentials, we can assess responses to the individual components, including direct measurements of suppression on each other, and various nonlinear responses to their combination found at intermodulation frequencies. The result is a rather rich dataset of frequencies at which responses can be found...
May 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28538724/applying-systems-level-spectral-imaging-and-analysis-to-reveal-the-organelle-interactome
#2
Alex M Valm, Sarah Cohen, Wesley R Legant, Justin Melunis, Uri Hershberg, Eric Wait, Andrew R Cohen, Michael W Davidson, Eric Betzig, Jennifer Lippincott-Schwartz
The organization of the eukaryotic cell into discrete membrane-bound organelles allows for the separation of incompatible biochemical processes, but the activities of these organelles must be coordinated. For example, lipid metabolism is distributed between the endoplasmic reticulum for lipid synthesis, lipid droplets for storage and transport, mitochondria and peroxisomes for β-oxidation, and lysosomes for lipid hydrolysis and recycling. It is increasingly recognized that organelle contacts have a vital role in diverse cellular functions...
May 24, 2017: Nature
https://www.readbyqxmd.com/read/28538200/fungi-diversity-from-different-depths-and-times-in-chicken-manure-waste-static-aerobic-composting
#3
Wenjie Gu, Yusheng Lu, Zhiyuan Tan, Peizhi Xu, Kaizhi Xie, Xia Li, Lili Sun
The Dirichlet multinomial mixtures mode was used to analyse illumina sequencing data to reveal both temporal and spatial variations of the fungi community present in the aerobic composting. Results showed that 670 operational taxonomic units (OTUs) were detected, and the dominant phylum was Ascomycota. There were four types of samples fungi communities during the composting process. Samples from the early composting stage were mainly grouped into type I and Saccharomycetales sp. was dominant. Fungi community in the medium composting stage were fallen into type II and III, Sordariales sp...
April 13, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28535596/leaf-litter-leachate-concentration-promotes-heterotrophy-in-freshwater-biofilms-understanding-consequences-of-water-scarcity
#4
Aingeru Martínez, John Stephen Kominoski, Aitor Larrañaga
Climate change is increasing overall temporal variability in precipitation resulting in a seasonal water availability, both increasing periods of flooding and water scarcity. During low water availability periods, the concentration of leachates from riparian vegetation increases, subsequently increasing dissolved organic matter (DOM). Moreover, shifts in riparian vegetation by land use changes impact the quantity and quality of DOM. Our objective was to test effects of increasing DOM concentrations from Eucalyptus grandis (one of the most cultivated tree species in the world) leachates on the metabolism (respiration, R; gross primary productivity, GPP) and extracellular enzyme activities (EEAs) of freshwater biofilms...
May 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28535553/differences-in-pain-processing-between-patients-with-chronic-low-back-pain-recurrent-low-back-pain-and-fibromyalgia
#5
Dorien Goubert, Lieven Danneels, Thomas Graven-Nielsen, Filip Descheemaeker, Mira Meeus
BACKGROUND: The impairment in musculoskeletal structures in patients with low back pain (LBP) is often disproportionate to their complaint. Therefore, the need arises for exploration of alternative mechanisms contributing to the origin and maintenance of non-specific LBP. The recent focus has been on central nervous system phenomena in LBP and the pathophysiological mechanisms underlying the various symptoms and characteristics of chronic pain. Knowledge concerning changes in pain processing in LBP remains ambiguous, partly due to the diversity in the LBP population...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28535409/mesial-temporal-lobe-epilepsy-diminishes-functional-connectivity-during-emotion-perception
#6
Bettina K Steiger, Angela M Muller, Esther Spirig, Gianina Toller, Hennric Jokeit
OBJECTIVES: Unilateral mesial temporal lobe epilepsy (MTLE) has been associated with impaired recognition of emotional facial expressions. Correspondingly, imaging studies showed decreased activity of the amygdala and cortical face processing regions in response to emotional faces. However, functional connectivity among regions involved in emotion perception has not been studied so far. METHODS: To address this, we examined intrinsic functional connectivity (FC) modulated by the perception of dynamic fearful faces among the amygdala and limbic, frontal, temporal and brainstem regions...
May 10, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28534870/time-compressed-preplay-of-anticipated-events-in-human-primary-visual-cortex
#7
Matthias Ekman, Peter Kok, Floris P de Lange
Perception is guided by the anticipation of future events. It has been hypothesized that this process may be implemented by pattern completion in early visual cortex, in which a stimulus sequence is recreated after only a subset of the visual input is provided. Here we test this hypothesis using ultra-fast functional magnetic resonance imaging to measure BOLD activity at precisely defined receptive field locations in visual cortex (V1) of human volunteers. We find that after familiarizing subjects with a spatial sequence, flashing only the starting point of the sequence triggers an activity wave in V1 that resembles the full stimulus sequence...
May 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28534735/the-use-of-the-gaps-in-noise-test-as-an-index-of-the-enhanced-left-temporal-cortical-thinning-associated-with-the-transition-between-mild-cognitive-impairment-and-alzheimer-s-disease
#8
Vasiliki Vivian Iliadou, Doris-Eva Bamiou, Christos Sidiras, Nikolaos P Moschopoulos, Magda Tsolaki, Ioannis Nimatoudis, Gail D Chermak
BACKGROUND: The known link between auditory perception and cognition is often overlooked when testing for cognition. PURPOSE: To evaluate auditory perception in a group of older adults diagnosed with mild cognitive impairment (MCI). RESEARCH DESIGN: A cross-sectional study of auditory perception. STUDY SAMPLE: Adults with MCI and adults with no documented cognitive issues and matched hearing sensitivity and age. DATA COLLECTION: Auditory perception was evaluated in both groups, assessing for hearing sensitivity, speech in babble (SinB), and temporal resolution...
May 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28534294/brain-derived-neurotrophic-factor-expression-in-individuals-with-schizophrenia-and-healthy-aging-testing-the-accelerated-aging-hypothesis-of-schizophrenia
#9
REVIEW
Farhana Islam, Benoit H Mulsant, Aristotle N Voineskos, Tarek K Rajji
PURPOSE OF REVIEW: Schizophrenia has been hypothesized to be a syndrome of accelerated aging. Brain plasticity is vulnerable to the normal aging process and affected in schizophrenia: brain-derived neurotrophic factor (BDNF) is an important neuroplasticity molecule. The present review explores the accelerated aging hypothesis of schizophrenia by comparing changes in BDNF expression in schizophrenia with aging-associated changes. RECENT FINDINGS: Individuals with schizophrenia show patterns of increased overall mortality, metabolic abnormalities, and cognitive decline normally observed later in life in the healthy population...
July 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28534154/chemoradiation-impairs-normal-developmental-cortical-thinning-in-medulloblastoma
#10
Palak Kundu, Matthew D Li, Ben Y Durkee, Susan M Hiniker, Karl Bush, Rie von Eyben, Michelle L Monje, Kristen W Yeom, Sarah S Donaldson, Iris C Gibbs
Medulloblastoma patients are treated with surgery, radiation and chemotherapy. Radiation dose to the temporal lobe may be associated with neurocognitive sequelae. Longitudinal changes of temporal lobe cortical thickness may result from neurodevelopmental processes such as synaptic pruning. This study applies longitudinal image analysis to compare developmental change in cortical thickness in medulloblastoma (MB) patients who were treated by combined modality therapy to that of cerebellar juvenile pilocytic astrocytoma (JPA) patients who were treated by surgery alone...
May 22, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28533968/changes-in-the-spatial-and-temporal-pattern-of-natural-forest-cover-on-hainan-island-from-the-1950s-to-the-2010s-implications-for-natural-forest-conservation-and-management
#11
Siliang Lin, Yaozhu Jiang, Jiekun He, Guangzhi Ma, Yang Xu, Haisheng Jiang
The study of the past, present, and future state and dynamics of the tropical natural forest cover (NFC) might help to better understand the pattern of deforestation and fragmentation as well as the influence of social and natural processes. The obtained information will support the development of effective conservation policies and strategies. In the present study, we used historical data of the road network, topography, and climatic productivity to reconstruct NFC maps of Hainan Island, China, from the 1950s to the 2010s, using the random forest algorithm...
2017: PeerJ
https://www.readbyqxmd.com/read/28533748/cerebral-dynamics-during-the-observation-of-point-light-displays-depicting-postural-adjustments
#12
Eduardo F Martins, Thiago Lemos, Ghislain Saunier, Thierry Pozzo, Daniel Fraiman, Claudia D Vargas
Objective: As highly social creatures, human beings rely part of their skills of identifying, interpreting, and predicting the actions of others on the ability of perceiving biological motion. In the present study, we aim to investigate the electroencephalographic (EEG) cerebral dynamics involved in the coding of postural control and examine whether upright stance would be codified through the activation of the temporal-parietal cortical network classically enrolled in the coding of biological motion. Design: We registered the EEG activity of 12 volunteers while they passively watched point light displays (PLD) depicting quiet stable (QB) and an unstable (UB) postural situations and their respective scrambled controls (QS and US)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28533540/recent-changes-in-daily-climate-extremes-in-an-arid-mountain-region-a-case-study-in-northwestern-china-s-qilian-mountains
#13
Pengfei Lin, Zhibin He, Jun Du, Longfei Chen, Xi Zhu, Jing Li
Changes in climate extremes pose far-reaching consequences to ecological processes and hydrologic cycles in alpine ecosystems of the arid mountain regions. Therefore, regional assessments in various climates and mountain regions are needed for understanding the uncertainties of the change trends for extreme climate events. The objective of this study was to assess the spatial distribution and temporal trends of extreme precipitation and temperature events responses to global warming on the arid mountain regions of China...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28533459/camouflage-through-colour-change-mechanisms-adaptive-value-and-ecological-significance
#14
REVIEW
Rafael C Duarte, Augusto A V Flores, Martin Stevens
Animals from a wide range of taxonomic groups are capable of colour change, of which camouflage is one of the main functions. A considerable amount of past work on this subject has investigated species capable of extremely rapid colour change (in seconds). However, relatively slow colour change (over hours, days, weeks and months), as well as changes arising via developmental plasticity are probably more common than rapid changes, yet less studied. We discuss three key areas of colour change and camouflage...
July 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28533406/spatiotemporal-dynamics-of-word-retrieval-in-speech-production-revealed-by-cortical-high-frequency-band-activity
#15
Stephanie K Riès, Rummit K Dhillon, Alex Clarke, David King-Stephens, Kenneth D Laxer, Peter B Weber, Rachel A Kuperman, Kurtis I Auguste, Peter Brunner, Gerwin Schalk, Jack J Lin, Josef Parvizi, Nathan E Crone, Nina F Dronkers, Robert T Knight
Word retrieval is core to language production and relies on complementary processes: the rapid activation of lexical and conceptual representations and word selection, which chooses the correct word among semantically related competitors. Lexical and conceptual activation is measured by semantic priming. In contrast, word selection is indexed by semantic interference and is hampered in semantically homogeneous (HOM) contexts. We examined the spatiotemporal dynamics of these complementary processes in a picture naming task with blocks of semantically heterogeneous (HET) or HOM stimuli...
May 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28533086/spatio-temporal-pattern-of-neuronal-differentiation-in-the-drosophila-visual-system-a-user-s-guide-to-the-dynamic-morphology-of-the-developing-optic-lobe
#16
Kathy T Ngo, Ingrid Andrade, Volker Hartenstein
Visual information processing in animals with large image forming eyes is carried out in highly structured retinotopically ordered neuropils. Visual neuropils in Drosophila form the optic lobe, which consists of four serially arranged major subdivisions; the lamina, medulla, lobula and lobula plate; the latter three of these are further subdivided into multiple layers. The visual neuropils are formed by more than 100 different cell types, distributed and interconnected in an invariant highly regular pattern...
May 19, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28532307/global-estimates-of-country-health-indicators-useful-unnecessary-inevitable
#17
Carla AbouZahr, Ties Boerma, Daniel Hogan
BACKGROUND: The MDG era relied on global health estimates to fill data gaps and ensure temporal and cross-country comparability in reporting progress. Monitoring the Sustainable Development Goals will present new challenges, requiring enhanced capacities to generate, analyse, interpret and use country produced data. OBJECTIVE: To summarize the development of global health estimates and discuss their utility and limitations from global and country perspectives. DESIGN: Descriptive paper based on findings of intercountry workshops, reviews of literatureon and synthesis of experiences...
January 2017: Global Health Action
https://www.readbyqxmd.com/read/28531219/pyldm-an-open-source-package-for-lifetime-density-analysis-of-time-resolved-spectroscopic-data
#18
Gabriel F Dorlhiac, Clyde Fare, Jasper J van Thor
Ultrafast spectroscopy offers temporal resolution for probing processes in the femto- and picosecond regimes. This has allowed for investigation of energy and charge transfer in numerous photoactive compounds and complexes. However, analysis of the resultant data can be complicated, particularly in more complex biological systems, such as photosystems. Historically, the dual approach of global analysis and target modelling has been used to elucidate kinetic descriptions of the system, and the identity of transient species respectively...
May 22, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28531202/the-role-of-density-dependent-and-independent-processes-in-spawning-habitat-selection-by-salmon-in-an-arctic-riverscape
#19
Brock M Huntsman, Jeffrey A Falke, James W Savereide, Katrina E Bennett
Density-dependent (DD) and density-independent (DI) habitat selection is strongly linked to a species' evolutionary history. Determining the relative importance of each is necessary because declining populations are not always the result of altered DI mechanisms but can often be the result of DD via a reduced carrying capacity. We developed spatially and temporally explicit models throughout the Chena River, Alaska to predict important DI mechanisms that influence Chinook salmon spawning success. We used resource-selection functions to predict suitable spawning habitat based on geomorphic characteristics, a semi-distributed water-and-energy balance hydrologic model to generate stream flow metrics, and modeled stream temperature as a function of climatic variables...
2017: PloS One
https://www.readbyqxmd.com/read/28531190/real-time-cell-toxicity-profiling-of-tox21-10k-compounds-reveals-cytotoxicity-dependent-toxicity-pathway-linkage
#20
Jui-Hua Hsieh, Ruili Huang, Ja-An Lin, Alexander Sedykh, Jinghua Zhao, Raymond R Tice, Richard S Paules, Menghang Xia, Scott S Auerbach
Cytotoxicity is a commonly used in vitro endpoint for evaluating chemical toxicity. In support of the U.S. Tox21 screening program, the cytotoxicity of ~10K chemicals was interrogated at 0, 8, 16, 24, 32, & 40 hours of exposure in a concentration dependent fashion in two cell lines (HEK293, HepG2) using two multiplexed, real-time assay technologies. One technology measures the metabolic activity of cells (i.e., cell viability, glo) while the other evaluates cell membrane integrity (i.e., cell death, flor). Using glo technology, more actives and greater temporal variations were seen in HEK293 cells, while results for the flor technology were more similar across the two cell types...
2017: PloS One
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