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https://www.readbyqxmd.com/read/29785783/silica-gelatin-hybrid-sol-gel-coatings-a-proteomic-study-with-biocompatibility-implications
#1
N Araújo-Gomes, F Romero-Gavilán, I Lara-Sáez, F Elortza, M Azkargorta, I Iloro, M Martínez-Ibañez, J J Martín de Llano, M Gurruchaga, I Goñi, J Suay, A M Sánchez-Pérez
Osseointegration, including the foreign body reaction to biomaterials, is an immune-modulated, multifactorial, and complex healing process in which various cells and mediators are involved. The buildup of the osseointegration process is immunological and inflammation-driven, often triggered by the adsorption of proteins on the surfaces of the biomaterials and complement activation. New strategies for improving osseointegration use coatings as vehicles for osteogenic biomolecules delivery from implants. Natural polymers, such as gelatin, can mimic collagen I and enhance the biocompatibility of a material...
May 21, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29784996/dual-function-injectable-angiogenic-biomaterial-for-the-repair-of-brain-tissue-following-stroke
#2
Lina R Nih, Shiva Gojgini, S Thomas Carmichael, Tatiana Segura
Stroke is the primary cause of disability due to the brain's limited ability to regenerate damaged tissue. After stroke, an increased inflammatory and immune response coupled with severely limited angiogenesis and neuronal growth results in a stroke cavity devoid of normal brain tissue. In the adult, therapeutic angiogenic materials have been used to repair ischaemic tissues through the formation of vascular networks. However, whether a therapeutic angiogenic material can regenerate brain tissue and promote neural repair is poorly understood...
May 21, 2018: Nature Materials
https://www.readbyqxmd.com/read/29781746/posterior-lamellar-reconstruction-a-comprehensive-review-of-the-literature
#3
Alessandra Fin, Fabrizio De Biasio, Paolo Lanzetta, Sebastiano Mura, Anna Tarantini, Pier Camillo Parodi
The aim of the review is to describe the different techniques and materials available to reconstruct the tarsoconjunctival layer of the eyelid; to analyze their indications, advantages, and disadvantages. We searched the Cochrane, PubMed, and Ovid MEDLINE databases for English articles published between January 1990 and January 2017 using variations of the following key words: "posterior lamella," "eyelid reconstruction," "tarsoconjunctival," "flap," and "graft." Two reviewers checked the abstracts of the articles found to eliminate redundant or not relevant articles...
May 21, 2018: Orbit
https://www.readbyqxmd.com/read/29781148/improved-osteogenesis-of-boron-incorporated-calcium-silicate-coatings-via-immunomodulatory-effects
#4
Xiang Lu, Kai Li, Youtao Xie, Shengcai Qi, Qingyi Shen, Jiangming Yu, Liping Huang, Xuebin Zheng
Osteoimmunology has revealed the importance of a favorable immune response for successful biomaterial-mediated osteogenesis. Boron-incorporated calcium silicate (Ca11 Si4 B2 O22 , B-CS) coating has been reported as a potential candidate for improving osteogenesis in orthopedic applications in vitro. However, relatively little is known about its effects on the immune response and subsequent osteogenesis. In this work, the immunomodulatory properties of the B-CS coating and its specific mechanism of action were explored...
May 20, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29776584/dopamine-assisted-co-deposition-an-emerging-and-promising-strategy-for-surface-modification
#5
REVIEW
Wen-Ze Qiu, Hao-Cheng Yang, Zhi-Kang Xu
Mussel-inspired chemistry based on polydopamine (PDA) deposition has been developed as a facile and universal method for the surface modification of various materials. However, the inherent shortcomings of PDA coatings still impede their practical applications in the development of functional materials. In this review, we introduce the recent progress in the emerging dopamine-assisted co-deposition as a one-step strategy for functionalizing PDA-based coatings, and improving them in the aspects of deposition rate, morphology uniformity, surface wettability and chemical stability...
April 27, 2018: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/29775436/modelling-the-degree-of-porosity-of-the-ceramic-surface-intended-for-implants
#6
Sebastian Stach, Olga Kędzia, Żaneta Garczyk, Zygmunt Wróbel
The main goal of the study was to develop a model of the degree of surface porosity of a biomaterial intended for implants. The model was implemented using MATLAB. A computer simulation was carried out based on the developed model, which resulted in a two-dimensional image of the modelled surface. Then, an algorithm for computerised image analysis of the surface of the actual oxide bioceramic layer was developed, which enabled determining its degree of porosity. In order to obtain the confocal micrographs of a few areas of the biomaterial, measurements were performed using the LEXT OLS4000 confocal laser microscope...
May 18, 2018: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/29774969/combined-effect-of-parathyroid-hormone-and-strontium-ranelate-on-bone-healing-in-ovariectomized-rats
#7
Funda Göker, Selim Ersanlı, Volkan Arısan, Erdal Cevher, Emine Elif Güzel, Halim İşsever, Beyhan Ömer, Gülay Durmuş Altun, Deniz Morina, Tuğba Ekiz Yılmaz, Elmire Dervişoğlu, Massimo Del Fabbro
OBJECTIVE: Parathyroid hormone (PTH) enhances bone healing. Strontium ranelate (SR) is an antiresorptive agent that increases bone formation. Reports about combined effects of PTH and SR on local bone regeneration in osteoporotic subjects are limited. We aimed at investigating the efficacy of PTH and SR for promoting new bone formation in critical sized defects of ovariectomized rats. MATERIALS AND METHODS: PTH- and/or SR-containing poloxamer implant tablets with/without chitosan microparticles were delivered locally to calvarial defects of 90 Wistar rats...
May 18, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29772248/scaffolds-for-peripheral-nerve-repair-and-reconstruction
#8
REVIEW
Sheng Yi, Lai Xu, Xiaosong Gu
Trauma-associated peripheral nerve defect is a widespread clinical problem. Autologous nerve grafting, the current gold standard technique for the treatment of peripheral nerve injury, has many internal disadvantages. Emerging studies showed that tissue engineered nerve graft is an effective substitute to autologous nerves. Tissue engineered nerve graft is generally composed of neural scaffolds and incorporating cells and molecules. A variety of biomaterials have been used to construct neural scaffolds, the main component of tissue engineered nerve graft...
May 14, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29771925/in-vitro-and-in-vivo-biological-performance-of-porous-ti-alloys-prepared-by-powder-metallurgy
#9
Renata Falchete do Prado, Gabriela Campos Esteves, Evelyn Luzia De Souza Santos, Daiane Acácia Griti Bueno, Carlos Alberto Alves Cairo, Luis Gustavo Oliveira De Vasconcellos, Renata Silveira Sagnori, Fernanda Bastos Pereira Tessarin, Felipe Eduardo Oliveira, Luciane Dias De Oliveira, Maria Fernanda Lima Villaça-Carvalho, Vinicius André Rodrigues Henriques, Yasmin Rodarte Carvalho, Luana Marotta Reis De Vasconcellos
Titanium (Ti) and Ti-6 Aluminium-4 Vanadium alloys are the most common materials in implants composition but β type alloys are promising biomaterials because they present better mechanical properties. Besides the composition of biomaterial, many factors influence the performance of the biomaterial. For example, porous surface may modify the functional cellular response and accelerate osseointegration. This paper presents in vitro and in vivo evaluations of powder metallurgy-processed porous samples composed by different titanium alloys and pure Ti, aiming to show their potential for biomedical applications...
2018: PloS One
https://www.readbyqxmd.com/read/29771495/rapid-growth-of-acetylated-a%C3%AE-16-20-into-macroscopic-crystals
#10
Christian Bortolini, Lasse Hyldgaard Klausen, Søren Vrønning Hoffmann, Nykola C Jones, Daniela Saadeh, Zegao Wang, Tuomas P J Knowles, Mingdong Dong
Aberrant assembly of the amyloid-β (Aβ) is responsible for the development of Alzheimer's disease, but can also be exploited to obtain highly functional biomaterials. The short Aβ fragment, KLVFF (Aβ16-20), is crucial for Aβ assembly and considered to be an Aβ aggregation inhibitor. Here, we show that acetylation of KLVFF turns it into an extremely fast self-assembling molecule, reaching macroscopic (i.e. mm) size in seconds. We show that KLVFF is metastable and that the self-assembly can be directed towards a crystalline or fibrillar phase simply through chemical modification, via acetylation or amidation of the peptide...
May 17, 2018: ACS Nano
https://www.readbyqxmd.com/read/29770578/effect-of-silicon-doped-calcium-phosphate-bone-grafting-materials-on-bone-regeneration-and-osteogenic-marker-expression-after-implantation-in-the-ovine-scapula
#11
Christine Knabe, Doaa Adel-Khattab, Wolf-Dietrich Hübner, Fabian Peters, Tom Knauf, Barbara Peleska, Dirk Barnewitz, Antje Genzel, Roderik Kusserow, Florian Sterzik, Michael Stiller, Christian Müller-Mai
Compared to the currently clinically available bone grafting materials for alveolar ridge augmentation, there is a great demand for bioactive bone substitutes with higher resorbability, which enhance osteogenesis at the same time. This has prompted the development of a silicon-doped rapidly resorbable calcium alkali orthophosphate (Si-CAOP) and silicon-doped β-tricalcium phosphate (Si-TCP). This study evaluated the effect of these two particulate graft materials as compared to the currently clinically used β-TCP on bone formation and osteogenic marker expression after 2 weeks, 1, 3, 6, 12, and 18 months of implantation in critical size defects in the sheep scapula...
May 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29770427/near-infrared-laser-mediated-modulation-of-ice-crystallization-by-two-dimensional-nanosheets-enables-high-survival-recovery-of-biological-cells-from-cryogenic-temperatures
#12
Fazil Panhwar, Zhongrong Chen, S M Chapal Hossain, Meng Wang, Zeeshan Haider, Kashan Memon, Pengpeng Chen, Gang Zhao
Two-dimensional (2D) graphene oxide (GO) and molybdenum disulfide (MoS2) nanosheets (NSs) have been widely used as photothermal agents and as potential carriers of antitumor drugs. Their spatial thermal effects have been extensively explored for use at physiological and hyperthermic temperatures (37 to 46 °C). Furthermore, the modulation of the spatial thermal distributions with these NSs may have even more profound applications in the microstructural control of biomaterials at cryogenic temperatures (-196 to 37 °C)...
May 17, 2018: Nanoscale
https://www.readbyqxmd.com/read/29770392/promotion-of-neurite-outgrowth-by-rationally-designed-ngf-%C3%AE-binding-peptide-nanofibers
#13
Zeynep Okur, Oya I Senturk, Canelif Yilmaz, Gulcihan Gulseren, Busra Mammadov, Mustafa O Guler, Ayse B Tekinay
Promotion of neurite outgrowth is an important limiting step for regeneration in nerve injury and depends strongly on the local expression of nerve growth factor (NGF). The rational design of bioactive materials is a promising approach for the development of novel therapeutic methods for nerve regeneration, and biomaterials capable of presenting NGF to nerve cells are especially suitable for this purpose. In this study, we show bioactive peptide amphiphile (PA) nanofibers capable of promoting neurite outgrowth by displaying high density binding epitopes for NGF...
May 17, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29768730/biofilm-in-voice-prosthesis-a-prospective-cohort-study-and-laboratory-tests-using-sonication-and-sem-analysis
#14
Jacopo Galli, Lea Calo', Duino Meucci, Monica Giuliani, Daniela Lucidi, Gaetano Paludetti, Riccardo Torelli, Maurizio Sanguinetti, Claudio Parrilla
OBJECTIVE: The objective of the study was to compare the biofilm growing pattern and its morphological extent on silicone and a teflon-like material using a sonication process and a Scanning Electron Microscope (SEM). DESIGN: A prospective cohort study and a laboratory study. SETTING: Otolaryngology -Head and Neck surgery Department and the Microbiology Institute. PARTICIPANTS: The participants included fifteen laryngectomized patients with phonatory prostheses, which were removed due to device failure, and two different kinds of phonatory prostheses from the laboratory (Provox 2 and ActiValve) that were artificially colonized by Candida albicans...
May 16, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29768120/three-dimensionally-printed-pearl-powder-poly-caprolactone-composite-scaffolds-for-bone-regeneration
#15
Xu Zhang, Xiaoyu Du, Dejian Li, Rongguang Ao, Bin Yu, Baoqing Yu
Pearl has great potential as a natural biomaterial for bone tissue engineering, but it suffers from low porosity, difficulty in molding, and poor anti-buckling property. In this study, we used the 3-D printing technique to fabricate original pearl powder and PCL composite scaffolds with different concentrations of pearl powder. The four groups of scaffolds were termed PCL, 30% Pearl/PCL, 50% Pearl/PCL and 80% Pearl/PCL scaffolds according to the proportion of pearl powder. The samples were systematically investigated by scanning electron microscopy (SEM), wide-angle XRD, liquid substitution, Zwick static materials testing, and energy dispersive X-ray analysis...
May 16, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29767463/mechanical-and-biological-properties-of-a-biodegradable-mg-zn-ca-porous-alloy
#16
Yong-Qiang Zhang, Yang Li, Huan Liu, Jing Bai, Ni-Rong Bao, Yue Zhang, Peng He, Jian-Ning Zhao, Li Tao, Feng Xue, Guang-Xin Zhou, Gen-Tao Fan
OBJECTIVES: As promising alternative to current metallic biomaterials, the porous Mg scaffold with a 3-D open-pore framework has drawn much attention in recent years due to its suitable biodegradation, biocompatibility, and mechanical properties for human bones. This experiment's aim is to study the mechanical properties, biosafety, and osteogenesis of porous Mg-Zn alloy. METHODS: A porous Mg-2Zn-0.3Ca (wt%) alloy was successfully prepared by infiltration casting, and the size of NaCl particles was detected by a laser particle size analyzer...
May 16, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29767186/mechanical-characterization-and-modeling-of-sponge-reinforced-hydrogel-composites-under-compression
#17
Lei Wu, Guoyong Mao, Guodong Nian, Yuhai Xiang, Jin Qian, Shaoxing Qu
Load-bearing applications of hydrogels call for materials with excellent mechanical properties. Despite the considerable progress in developing tough hydrogels, there is still a requirement to prepare high-performance hydrogels using simple strategies. In this paper, a sponge-reinforced hydrogel composite is synthesized by combining poly(acrylamide) (PAAm) hydrogel and polyurethane (PU) sponge. Uniaxial compressive testing of the hydrogel composites reveals that both the compressive modulus and the strength of the hydrogel composites are much higher than those of the PAAm hydrogel or sponge...
May 16, 2018: Soft Matter
https://www.readbyqxmd.com/read/29766780/soft-biomaterial-based-nanocrystal-in-pharmaceutical
#18
Nandi Chen, Taojunfeng Su, Zhe Cheng, Feifei An
BACKGROUND AND OBJECTIVE: Bio-soft material, a class of derivatives of the natural or synthetic material, is getting more and more prevalent in biomedical researches and applications due to the advantages such as in-vivo biodegradation, good water solubility and designable targeting ability. With the presence of bio-soft materials, the drug nanocrystal can be easily generated and aggregated in a feasible process. Given the promising application of the bio-soft material in biological and chemical research, it is valuable to discuss the crucial step in designing bio-soft materials and analyze the emerging properties of bio-soft materials...
May 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29765941/nano-and-micro-patterned-s-h-and-x-pdms-for-cell-based-applications-comparison-of-wettability-roughness-and-cell-derived-parameters
#19
Marina Scharin-Mehlmann, Aaron Häring, Mathias Rommel, Tobias Dirnecker, Oliver Friedrich, Lothar Frey, Daniel F Gilbert
Polydimethylsiloxane (PDMS) is a promising biomaterial for generating artificial extracellular matrix (ECM) like patterned topographies, yet its hydrophobic nature limits its applicability to cell-based approaches. Although plasma treatment can enhance the wettability of PDMS, the surface is known to recover its hydrophobicity within a few hours after exposure to air. To investigate the capability of a novel PDMS-type (X-PDMS) for in vitro based assessment of physiological cell properties, we designed and fabricated plane as well as nano- and micrometer-scaled pillar-patterned growth substrates using the elastomer types S-, H- and X-PDMS, which were fabricated from commercially available components...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29763386/trends-in-polymeric-electrospun-fibers-and-their-use-as-oral-biomaterials
#20
Agnes B Meireles, Daniella K Corrêa, João Vw da Silveira, Ana Lg Millás, Edison Bittencourt, Gustavo Ea de Brito-Melo, Libardo A González-Torres
Electrospinning is one of the techniques to produce structured polymeric fibers in the micro or nano scale and to generate novel materials for biomedical proposes. Electrospinning versatility provides fibers that could support different surgical and rehabilitation treatments. However, its diversity in equipment assembly, polymeric materials, and functional molecules to be incorporated in fibers result in profusion of recent biomaterials that are not fully explored, even though the recognized relevance of the technique...
May 2018: Experimental Biology and Medicine
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